Product version Darrell R. Abernethy Elizabeth Blair Izabela Birsanescu Keith Burkhart Luca Toldo Mathias Brochhausen Sydni Joubran "Asiyah" Yu Lin Abra Guo Barry Smith Bingjian Yang David Ameriguian Desikan Jagannathan Edison Ong Jessica DeGuise Jiangan "Hardy" Xie Jiangan Xie Kelly Yang Kevin Mo Ling Wan Liwei Wang Meiu Wong Noemi Garg Qingping Liu Qiuyue Yang Rebecca Racz Shelley Zhang Sirarat Sarntivijai Sydni Joubran Yongqun "Oliver" He (YH) Zuoshuang "Allen" Xiang 2022-8-15 The Ontology of Adverse Eventsy (OAE) is a biomedical ontology in the domain of adverse events. OAE aims to standardize adverse event annotation, integrate various adverse event data, and support computer-assisted reasoning. OAE is a community-based ontology. Its development follows the OBO Foundry principles. Vaccine adverse events have been used as an initial testing use case. OAE also studies adverse events associated with the administration of drug and nutritional products, the operation of surgeries, and the usage of medical devices, etc. OWL-DL An ontology for the annotation of the adverse event domain. OAE: Ontology of Adverse Events 1.2.47 Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label BFO OWL specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label BFO CLIF specification label editor preferred label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label example A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> example of usage example of usage has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot OBI_0000281 has curation status has curation status definition definition textual definition The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition definition textual definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obfoundry.org/obo/obi> IAO:0000116 uberon editor_note 1 editor_note editor note editor note term editor Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition editor term editor term editor alternative term An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> alternative term alternative term definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source definition source curator note An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg IAO:0000232 uberon curator_notes 1 curator_notes curator note curator note curator notes imported from For external terms/classes, the ontology from which the term was imported PERSON:Alan Ruttenberg PERSON:Melanie Courtot GROUP:OBI:<http://purl.obolibrary.org/obo/obi> imported from imported from expand expression to expand expression to expand assertion to expand assertion to elucidation person:Alan Ruttenberg Person:Barry Smith Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms elucidation elucidation has associated axiom(nl) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom associated with a term expressed using natural language has associated axiom(nl) has associated axiom(nl) has associated axiom(fol) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom expressed in first order logic using CLIF syntax has associated axiom(fol) has associated axiom(fol) has axiom label YH, JX a chinese translation represents a chinese translation of the existing term. Chinese translation Chinese translation The AE 'cough AE' has the 'label of AE outcome' of 'cough'; 'infection AE' has the 'label of AE outcom' of 'infection'. an annotation property that represents the label of an adverse event Yongqun Oliver He, Jiangan Hardy Xie label of adverse event outcome adverse event outcome adverse event outcome has_MedDRA_id has_MedDRA_id An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. temporal interpretation temporal interpretation https://github.com/oborel/obo-relations/wiki/ROAndTime tooth SubClassOf 'never in taxon' value 'Aves' x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL. Chris Mungall ?X DisjointWith RO_0002162 some ?Y never in taxon An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon. taxonomic class assertion taxonomic class assertion S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. RO:0002174 uberon dubious_for_taxon 1 1 dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost dubious_for_taxon S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S RO:0002175 applicable for taxon uberon present_in_taxon 1 1 present_in_taxon present_in_taxon An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL. logical macro assertion logical macro assertion https://github.com/oborel/obo-relations/wiki/ShortcutRelations A logical macro assertion whose domain is an IRI for a class The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL logical macro assertion on a class logical macro assertion on a class A logical macro assertion whose domain is an IRI for a property logical macro assertion on a property logical macro assertion on a property logical macro assertion on an object property logical macro assertion on an object property logical macro assertion on an annotation property logical macro assertion on an annotation property relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q' Chris Mungall is direct form of An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. UBPROP:0000001 uberon external_definition 1 external_definition This annotation property may be replaced with an annotation property from an external ontology such as IAO external_definition A textual description of an axiom loss in this ontology compared to an external ontology. UBPROP:0000002 uberon axiom_lost_from_external_ontology 1 axiom_lost_from_external_ontology This annotation property may be replaced with an annotation property from an external ontology such as IAO axiom_lost_from_external_ontology Notes on the homology status of this class. UBPROP:0000003 uberon homology_notes 1 homology_notes This annotation property may be replaced with an annotation property from an external ontology such as IAO homology_notes An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info. UBPROP:0000005 uberon external_comment 1 external_comment This annotation property may be replaced with an annotation property from an external ontology such as IAO external_comment UBPROP:0000006 uberon implements_design_pattern 1 implements_design_pattern implements_design_pattern Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. UBPROP:0000007 uberon has_relational_adjective 1 has_relational_adjective has_relational_adjective Notes on the how instances of this class vary across species. UBPROP:0000008 uberon taxon_notes 1 taxon_notes taxon_notes Notes on the evolved function of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000009 uberon function_notes 1 function_notes function_notes Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 uberon structure_notes 1 structure_notes structure_notes Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 uberon development_notes 1 development_notes development_notes Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 uberon external_ontology_notes 1 external_ontology_notes external_ontology_notes Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000013 uberon terminology_notes 1 terminology_notes terminology_notes UBPROP:0000100 uberon is_count_of 1 is_count_of is count of A property used in conjunction with repeated_element_number to indicate an axis and directionality along that axis. If P preceding_element_is R, and P is_count_of S, and X P N, and X' P N+1, then it follows that every X R some X', and the class expression [S and R some X' and inv(R) some X] is empty (i.e. X is followed by X', with no intermediates) UBPROP:0000101 uberon preceding_element_is 1 preceding_element_is preceding element is x pharyngeal_arch_number N if and only if (i) x is a pharyngeal arch, and (ii) x is ancestrally pharyngeal arch number N in a series of pharyngeal arches repeated along a antero-posterior axis, with arch_number 1 being the mandibular arch. gill arch N = PA N-2. the term branchial_arch is ambiguous. UBPROP:0000103 uberon pharyngeal_arch_number 1 pharyngeal_arch_number pharyngeal arch number x phalanx_number N if and only if (i) x is a phalanx, and (ii) x is phalanx number N in a series of phalanges repeated along an prixomo-distal axis, with phalanx_number 1 being the proximalmost phalanx. Note that in humans, the distalmost phalanx has phlanax_number 3, except in ray_number 1, where the distalmost has phalanx_number 2 UBPROP:0000105 uberon phalanx_number 1 phalanx_number Most land mammals including humans have a 2-3-3-3-3 formula in both the hands (or paws) and feet. Primitive reptiles typically had the formula 2-3-4-4-5, and this pattern, with some modification, remained in many later reptiles and in the mammal-like reptiles. The phalangeal formula in the flippers of cetaceans (marine mammals) is 2-12-8-1 phalanx number FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term UBPROP:0000202 uberon fma_set_term 1 fma_set_term fma_set_term eco subset CUMBO developmental_classification A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes. EFO slim derived from the union of EHDAA2 and EMAPA - still to be checked functional_classification Subset consisting of classes creating for grouping purposes A grouping class that depends on an assumption of homology between subclasses classes that have some inconsistency with FMA somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads abstract class brought in to group ontology classes but not informative organs, excluding individual muscles and skeletal elements Phenotype slim Uberon slim - subset that excludes obscure terms and deep compositional terms abstract upper-level terms not directly useful for analysis core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO uberon dc-contributor 1 dc-contributor contributor Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content. An account of the content of the resource. Description Description The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system. A reference to a resource from which the present resource is derived. Source Source subset_property has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym in_subset shorthand label label label uberon foaf-depicted_by 1 foaf-depicted_by depicted_by is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime part_of BFO:0000050 uberon part_of part_of part of part of http://www.obofoundry.org/ro/#OBO_REL:part_of has part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime has_part BFO:0000051 uberon has_part has_part has part has part realized in this disease is realized in this disease course this fragility is realized in this shattering this investigator role is realized in this investigation is realized by realized_in [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realized in realizes this disease course realizes this disease this investigation realizes this investigator role this shattering realizes this fragility to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realizes preceded by X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 is preceded by takes place after uberon preceded_by preceded_by preceded by preceded_by precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. BFO:0000063 uberon precedes precedes precedes precedes occurs in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t occurs_in unfolds in unfolds_in Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant occurs in site of [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant contains process x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer cjm 2009-07-31T02:15:46Z BSPO:0000096 uberon anterior_to anterior_to anterior_to x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal). BSPO:0000097 uberon distal_to distal_to distal_to x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000098 uberon dorsal_to dorsal_to dorsal_to x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. BSPO:0000099 caudal_to uberon posterior_to posterior_to posterior_to x proximal_to y iff x is closer to the point of attachment with the body than y. BSPO:0000100 uberon proximal_to proximal_to proximal_to x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000102 uberon ventral_to ventral_to ventral_to Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. BSPO:0000107 uberon deep_to deep_to deep_to Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. BSPO:0000108 uberon superficial_to superficial_to superficial_to X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion. BSPO:0000120 uberon in_left_side_of in_left_side_of in_left_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion. BSPO:0000121 uberon in_right_side_of in_right_side_of in_right_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. BSPO:0000122 uberon in_posterior_side_of in_posterior_side_of in_posterior_side_of X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. BSPO:0000123 uberon in_anterior_side_of in_anterior_side_of in_anterior_side_of X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. BSPO:0000124 uberon in_proximal_side_of in_proximal_side_of in_proximal_side_of X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. BSPO:0000125 uberon in_distal_side_of in_distal_side_of in_distal_side_of X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure BSPO:0000126 uberon in_lateral_side_of in_lateral_side_of in_lateral_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y BSPO:0001106 uberon proximalmost_part_of proximalmost_part_of proximalmost_part_of X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y BSPO:0001108 uberon distalmost_part_of distalmost_part_of distalmost_part_of a preceded_by relation that indicates that one process (e.g., an adverse event) is causally preceded by (induced by) another process (e.g., a medical intervention) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. Yongqun He induced by induced_by the relation indicates that one process (e.g., a medical intervention) induces another process (e.g., an adverse event) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. This is an inverse relation of the term "induced_by". YH, AG induces This is a tentative relation. We need to get this role from another ontology later. Oliver -- BFO 2.0 has this role 'is role of':: http://purl.obolibrary.org/obo/BFO_0000081 Once we get BFO 2.0, we can replace with this role. Oliver role_of An electrocardiogram qt prolonged AE is_evidence_of arrhythmia AE; arrhythmia AE is_evidence_of cardiomyopathy AE; fever AE is_evidence_of inflammation AE; fever AE is_evidence_of viral infection AE; plural effusion AE is_evidence_of cardiac disorder AE. AE1 is_evidence_of AE2 if and only if: given an adverse event instance ae1 that instantiates class AE1 (e.g., electrocardiogram qt prolonged AE) and another adverse event instance ae2 that instantiates class AE2 (e.g., arrhythmia AE), both ae1 and ae2 are adverse events that are clinically observed after a medical intervention (at time t0) on the same patient. The presence of ae1 is supported by priori knowledge of medicine to imply the presence of ae2 with some probability P (P is NOT always 1, thus transitivity does not apply to is_evidence_of relation. AE1 is_evidence_of AE2 and AE2 is_evidence_of AE3 DOES NOT imply AE1 is_evidence_of AE3). The instance ae1 and ae2 are observed or detected at time t1 and t2, respectively. The biological onset time for ae1 or ae2 may occur before t1 or t2. The t1 and t2 can be the same time point or different time points. This represents a relation between two adverse events AE1 and AE2. However, AE1 may be an evidence of another adverse event AE3, and a dfferent adverse event AE4 may also be an evidence of the same AE2. SS, YH, YL is evidence of An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased. an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. This is a shortcut relation of the following full version: 'has participant' some (participant 'has quality' ) in: process 'has participant' some (participant 'has quality' some quality) Yongqun He has participant quality a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. Yongqun He adverse event occurs in AE occurs in A shortcut relation that represents the full path of ‘has participant’ some participant that ‘participates in’ some process. Yongqun He has participant undergoing a specific 'preceded by' object property that has a domain of an adverse event. Yongqun He adverse event preceded by bearer of this apple is bearer of this red color this vase is bearer of this fragility a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of is bearer of bearer of has participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant this apple has quality this red color a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. has_quality has quality this person has role this investigator role (more colloquially: this person has this role of investigator) a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. has_role has role RO:0001015 uberon location_of location_of location_of RO:0001025 uberon located_in located_in located_in RO:0002002 uberon has_boundary has_boundary has boundary FMA:85999 dbprop:nerve RO:0002005 nerve supply uberon innervated_by innervated_by http://code.google.com/p/obo-relations/issues/detail?id=6 innervated_by RO:0002007 uberon bounding_layer_of bounding_layer_of A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. bounding layer of David Osumi-Sutherland <= Primitive instance level timing relation between events before or simultaneous with Relation between occurrents, shares start and end boundaries. David Osumi-Sutherland RO:0002082 coincides_with is_equal_to uberon simultaneous_with simultaneous_with t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) simultaneous with simultaneous_with David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) David Osumi-Sutherland starts_at_end_of A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]. RO:0002087 directly preceded by is directly preceded by is immediately preceded by starts_at_end_of uberon immediately_preceded_by immediately_preceded_by X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately preceded by immediately_preceded_by David Osumi-Sutherland ends_at_start_of meets X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) immediately precedes David Osumi-Sutherland io X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y)) starts during David Osumi-Sutherland d during X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) happens during David Osumi-Sutherland o overlaps X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). ends during x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) overlaps RO:0002134 uberon innervates innervates http://code.google.com/p/obo-relations/issues/detail?id=6 innervates RO:0002150 uberon continuous_with continuous_with continuous_with RO:0002158 uberon homologous_to homologous_to homologous_to Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. RO:0002170 uberon connected_to connected_to Connection does not imply overlaps. connected to Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect) RO:0002176 uberon connects connects connects RO:0002177 uberon attaches_to_part_of attaches_to_part_of attaches_to_part_of relation between an artery and the structure is supplies with blood. FMA:86003 RO:0002178 arterial supply of uberon supplies supplies source: FMA supplies RO:0002179 drains blood from drains from uberon drains drains source: Wikipedia drains RO:0002202 uberon develops_from develops_from develops_from RO:0002203 uberon develops_into develops_into develops_into x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y RO:0002219 uberon surrounded_by surrounded_by surrounded_by x adjacent_to y iff: x and y share a boundary RO:0002220 uberon adjacent_to adjacent_to adjacent_to inverse of surrounded_by RO:0002221 uberon surrounds surrounds surrounds Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to Relation between occurrents, shares a start boundary with. RO:0002223 uberon starts starts starts Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall started by RO:0002224 uberon starts_with starts_with starts with starts with Relation between occurrents, shares an end boundary with. RO:0002229 finishes uberon ends ends ends x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall finished by RO:0002230 uberon ends_with ends_with ends with ends with RO:0002254 uberon has_developmental_contribution_from has_developmental_contribution_from has developmental contribution from t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. RO:0002256 uberon developmentally_induced_by developmentally_induced_by sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F) developmentally_induced_by RO:0002258 uberon developmentally_preceded_by developmentally_preceded_by developmentally preceded by RO:0002285 uberon developmentally_replaces developmentally_replaces developmentally_replaces example of usage: every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062); an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists. Chris Mungall results in formation of A mereological relationship or a topological relationship Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships mereotopologically related to RO:0002351 uberon has_member has_member has member FMA:85990 RO:0002371 uberon attaches_to attaches_to attaches_to we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve FMA:85994 RO:0002380 uberon branching_part_of branching_part_of branching_part_of x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y RO:0002385 uberon has_potential_to_developmentally_contribute_to has_potential_to_developmentally_contribute_to has potential to developmentally contribute to x has the potential to develop into y iff x develops into y or if x is capable of developing into y RO:0002387 uberon has_potential_to_develop_into has_potential_to_develop_into has potential to develop into RO:0002433 uberon contributes_to_morphology_of contributes_to_morphology_of contributes to morphology of x composed_primarily_of y iff: more than half of the mass of x is made from parts of y UBREL:0000002 RO:0002473 uberon composed_primarily_of composed_primarily_of composed primarily of Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. BFO:0000068 RO:0002488 begins_to_exist_during uberon existence_starts_during existence_starts_during existence starts during Relation between continuant and occurrent, such that c comes into existence at the start of p. RO:0002489 uberon existence_starts_with existence_starts_with existence starts with Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. BFO:0000069 RO:0002492 ceases_to_exist_during uberon existence_ends_during existence_ends_during existence ends during Relation between continuant and occurrent, such that c ceases to exist at the end of p. RO:0002493 uberon existence_ends_with existence_ends_with existence ends with RO:0002494 transforms from uberon transformation_of transformation_of transformation of RO:0002495 direct_transformation_of immediately transforms from uberon immediate_transformation_of immediate_transformation_of immediate transformation of RO:0002496 uberon existence_starts_during_or_after existence_starts_during_or_after existence starts during or after RO:0002497 uberon existence_ends_during_or_before existence_ends_during_or_before existence ends during or before RO:0002507 uberon has_material_contribution_from has_material_contribution_from has material contribution from A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. RO:0002551 uberon has sekeletal support has supporting framework has_skeleton has_skeleton has skeleton RO:0002569 uberon has_branching_part has_branching_part has_branching_part RO:0002572 uberon luminal_space_of luminal_space_of luminal space of RO:0002576 uberon skeleton_of skeleton_of skeleton of RO:0003000 uberon produces produces produces RO:0003001 uberon produced_by produced_by produced_by x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. uberon anteriorly_connected_to anteriorly connected to carries uberon channel_for channel for uberon channels_from channels_from uberon channels_into channels_into x is a conduit for y iff y passes through the lumen of x. uberon conduit_for conduit for x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. uberon distally_connected_to distally connected to uberon evolved_from Status: experimental evolved_from uberon existence_starts_and_ends_during existence starts and ends during uberon extends_fibers_into extends_fibers_into X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides. uberon in_central_side_of in_central_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. uberon posteriorly_connected_to posteriorly connected to uberon protects protects x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. uberon proximally_connected_to proximally connected to uberon subdivision_of placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B subdivision of . uberon transitively_anteriorly_connected_to transitively anteriorly connected to uberon transitively_connected_to transitively_connected to . uberon transitively_distally_connected_to transitively distally connected to . uberon transitively_proximally_connected_to transitively proximally connected to A data property that indicates that a material entity has a particular size. Yongqun He has size A ulcer has a diameter in cm some specific decimal length A 'has size' object property that indicates a material entity of round shape has a diameter of a particular length with the cm (centimeter) unit. Yongqun He has diameter in cm entity Entity Julius Caesar Verdi’s Requiem the Second World War your body mass index BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) entity continuant Continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] continuant occurrent Occurrent An entity that has temporal parts and that happens, unfolds or develops through time. BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] occurrent ic IndependentContinuant a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism the bottom right portion of a human torso the interior of your mouth A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] independent continuant t-region TemporalRegion Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] temporal region process Process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process disposition Disposition an atom of element X has the disposition to decay to an atom of element Y certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocytosis and exocytosis BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] disposition realizable RealizableEntity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] realizable entity quality Quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality sdc SpecificallyDependentContinuant Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] specifically dependent continuant role Role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role object-aggregate ObjectAggregate a collection of cells in a blood biobank. a swarm of bees is an aggregate of members who are linked together through natural bonds a symphony orchestra an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team) defined by fiat: the aggregate of members of an organization defined through physical attachment: the aggregate of atoms in a lump of granite defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container defined via attributive delimitations such as: the patients in this hospital the aggregate of bearings in a constant velocity axle joint the aggregate of blood cells in your body the nitrogen atoms in the atmosphere the restaurants in Palo Alto your collection of Meissen ceramic plates. An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee). ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158. b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004]) (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] object aggregate site Site Manhattan Canyon) a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] site object Object atom cell cells and organisms engineered artifacts grain of sand molecule organelle organism planet solid portions of matter star BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting. BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below). BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47 BFO 2 Reference: an object is a maximal causally unified material entity BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74 b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001]) object gdc GenericallyDependentContinuant The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] generically dependent continuant function Function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] function 1d-t-region OneDimensionalTemporalRegion the temporal region during which a process occurs. BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks). A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] one-dimensional temporal region material MaterialEntity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] material entity immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial entity r-quality RelationalQuality John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. a marriage bond, an instance of love, an obligation between one person and another. b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] relational quality 0d-t-region ZeroDimensionalTemporalRegion a temporal region that is occupied by a process boundary right now the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. temporal instant. A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] zero-dimensional temporal region A nervous system disease that is located_in nerves or nerve cells. ICD10CM:G62.9 NCI:C4731 SNOMEDCT_US_2018_03_01:193167000 SNOMEDCT_US_2018_03_01:264554005 SNOMEDCT_US_2018_03_01:277317008 SNOMEDCT_US_2018_03_01:277878001 SNOMEDCT_US_2018_03_01:386033004 SNOMEDCT_US_2018_03_01:42658009 UMLS_CUI:C0442874 peripheral neuropathy disease_ontology DOID:870 neuropathy Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. GO:0000004 GO:0007582 Wikipedia:Biological_process biological process physiological process biological_process GO:0008150 Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. biological_process Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo. biological_process accidental cell death necrosis GO:0008219 This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. cell death Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. GO:0008151 GO:0050875 cell physiology cellular physiological process cell growth and/or maintenance biological_process GO:0009987 cellular process A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. Wikipedia:Death biological_process GO:0016265 See also the biological process term 'apoptosis ; GO:0006915'. death A biological process that involves only one organism. janelomax 2012-09-19T15:05:24Z single organism process biological_process GO:0044699 single-organism process Any process that is carried out at the cellular level, occurring within a single organism. janelomax 2012-12-11T16:56:55Z biological_process GO:0044763 single-organism cellular process A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. necrosis cellular necrosis biological_process GO:0070265 Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'. necrotic cell death data item Data items include counts of things, analyte concentrations, and statistical summaries. a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers. 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum. 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym. 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/ JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief PERSON: Alan Ruttenberg PERSON: Chris Stoeckert PERSON: Jonathan Rees data data item information content entity Examples of information content entites include journal articles, data, graphical layouts, and graphs. A generically dependent continuant that is about some thing. 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ). information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity. PERSON: Chris Stoeckert OBI_0000142 information content entity textual entity Words, sentences, paragraphs, and the written (non-figure) parts of publications are all textual entities A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc. AR, (IAO call 2009-09-01): a document as a whole is not typically a textual entity, because it has pictures in it - rather there are parts of it that are textual entities. Examples: The title, paragraph 2 sentence 7, etc. MC, 2009-09-14 (following IAO call 2009-09-01): textual entities live at the FRBR (http://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records) manifestation level. Everything is significant: line break, pdf and html versions of same document are different textual entities. PERSON: Lawrence Hunter text textual entity hypothesis textual entity that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper 'Pilot clinical study to evaluate the anticoagulant activity of fucoidan', by Lowenthal et. al.PMID:19696660 A textual entity that expresses an assertion that is intended to be tested. 2009/09/28 Alan Ruttenberg. Fucoidan-use-case Person:Alan Ruttenberg hypothesis textual entity a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'. YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device. YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention. YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623. YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740. YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events. YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'. Yongqun He AE adverse reaction WEB: http://en.wikipedia.org/wiki/Adverse_event WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068 The OAE official website is: http://www.oae-ontology.org/. adverse event medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States," Reference: http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis. YH WEB: http://wiki.answers.com/Q/What_is_medical_intervention medical intervention an adverse event which is a causal adverse event, a pathological bodily process that is induced by a medical intervention. YH: The term 'causal adverse event' has the same meaning as we previously defined as 'adverse event'. Reference: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing as a way to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. YH adverse effect He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. YH: the term "adverse effect" has the same meaning of "causal adverse event". causal adverse event an adverse event that occurs after a vaccination. YH vaccine adverse event an adverse event that occurs after a drug administration YH, JX ADE ADR adverse drug reaction drug adverse event adverse drug event an adverse event that is associated with the usage of a medical device. YH This term is obsolete due to another term that has the same meaning. obsolete: medical device adverse event an adverse event that is associated with eating a medical food. YH medical food adverse event an adverse event that is induced by consuming a nutritional product. YH nutritional product adverse event an adverse event that is associated with consuming a dietary supplement. YH dietary supplement adverse event an adverse event that is associated with consuming an infant formula. YH infant formula adverse event a medical intervention where a patient is administered with a drug YH drug administration a medical intervention that uses a medical device YH medical device usage for medical intervention a medical intervention that uses a nutritional product YH consumption of nutritional product nutritional product usage a nutritional product usage that consumes a dietary supplement YH dietary supplement consumption a nutritional product usage that consumes infant formula YH consumption of infant formula a nutritional product usage that consumes medial food YH consumption of medical food an imaging investigation result abnormal AE that is characterized by an abnormal X-ray SS, YH, EB 10048065 X-ray result abnormal AE an X-ray result abnormal AE that has an outcome of an abnormality in chest X-ray test SS, YH 10008499 chest X-ray abnormal AE a haematoma AE that has an outcome of contusion. SS, YH WEB: http://en.wikipedia.org/wiki/Bruise 10050584 Contusion is a type of relatively minor hematoma of tissue in which capillaries and sometimes venules are damaged by trauma, allowing blood to seep into the surrounding interstitial tissues. contusion AE a digestive system AE which has an outcome of dry throat, which is a sensation of dryness in the throat. SS, YH 10013789 dry throat AE a skin discoloration AE which has an outcome of flushing, a sudden reddening of the face, neck, or upper chest SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003241.htm 脸红 10016825 flushing AE CTCAE:E13771 HPO: HP_0001033 NCIt:C26775 SIDER: C0016382 a pain AE where the pain reachs an extreme level. SS, YH, MW 10033425 pain in extremity AE CTCAE: E12512 HPO: HP_0009763 NCIt: C78515 SIDER: C0030196 a respiratory system AE which has an outcome of postnasal drip, which occurs when excessive mucus is produced by the nasal Mucosa. The excess mucus accumulates in the throat or back of the nose. SS, YH PDN UACS Upper Airway Cough Syndrome WEB: http://en.wikipedia.org/wiki/Post-nasal_drip 10036402 postnasal drip AE CTCAE: E13514 NCIt: C78566 a syndrome AE that is subclassified as five defined entities which represent clinical circumstances in which both the heart and the kidney are involved in a bidirectional injury and dysfunction via a final common pathway of cell-to-cell death and accelerated apoptosis mediated by oxidative stress. Types 1 and 2 involve acute and chronic cardiovascular disease (CVD) scenarios leading to acute kidney injury or accelerated chronic kidney disease. Types 2 and 3 describe acute and chronic kidney disease leading primarily to heart failure, although it is possible that acute coronary syndromes, stroke, and arrhythmias could be CVD outcomes in these forms of CRS. Finally, CRS type 5 describes a simultaneous insult to both heart and kidneys, such as sepsis, where both organs are injured simultaneously. SS, YH CRS WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030731/ 10068230 cardiorenal syndrome AE A bursal disorder AE that has an outcome of the symptom of bursitis. SS, YH bursa inflammation WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001456/ bursitis AE an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue. YH, RR, JX musculoskeletal and connective tissue disorder AE WEB: http://www.cdc.gov/niosh/programs/msd/ 10028395 A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture musculoskeletal or connective tissue AE CTCAE: E13872 A statistical test can be used to accept or reject the hypothesis. YH a hypothesis about the causal relation between an adverse event and a medical intervention. This term can be used to hypothesize and evaluate the relation between a medical intervention (e.g., drug, vaccination) and case reports from an adverse event reporting system (e.g., VAERS). CAE hypothesis causal adverse event hypothesis a musculoskeletal system AE which has an outcome of bursal disorder YH bursal disorder AE a vaccine adverse event that is induced by an influenza vaccine. YH: This term is just used as an example of vaccine induced adverse events. Specific vaccine-associated and vaccine-induced adverse events are now represented with the Ontology of Vaccine Adverse Events (OVAE).: http://www.violinet.org/ovae/. YH influenza vaccine-induced adverse event an influenza vaccine adverse event that is induced by a killed influenza vaccine (KIV). YH KIV-induced adverse event A KIV-induced AE that results in a GBS. YH VAERS statistical data analysis There is little evidence to support a causal association between GBS and most vaccines. The evidence for a causal association is strongest for the swine influenza vaccine that was used in 1976-77. Studies of influenza vaccines used in subsequent years, however, have found small or no increased risk of GBS. Reference: http://www.ncbi.nlm.nih.gov/pubmed?term=19388722. KIV-induced GBS averse event in 1976-1977 a muscle pain AE that is induced by Afluria influenza vaccine administration YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced muscle ache AE a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. lethargy is sometimes reported as an extreme fatigue: http://the-difference-between.com/lethargy/fatigue they are sometimes regarded as synonyms: https://www.nlm.nih.gov/medlineplus/ency/article/003088.htm SS, YH, MW lethargy AE WEB: http://en.wikipedia.org/wiki/Fatigue_%28medical%29 10016256 10024264 fatigue AE CTCAE: E11098 (fatigue); CTCAE: E12709 (lethargy) HPO: HP_0003388 NCIt: C3036; NCIt: C78416 SIDER: C0015672 a microbiology and serology investigation result abnormal AE that has an outcome of CSF culture negative. The negative result means no bacteria, viruses, or fungi grew in the laboratory dish. YH: The negative result is normal. It is not an AE. SS, YH, EB CSF culture negative AE a lab test abnormal AE that has an outcome of an abnormal result in a blood cell lab test SS, YH blood cell lab test abnormal AE an eosinophil percentage abnormal AE that has an outcome of increased eosinophil percentage YH, EB 10052222 eosinophil percentage increased AE a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by an obstruction of the blood supply to the heart SS WEB: http://www.ncbi.nlm.nih.gov/mesh/68009203 心肌梗塞 10028596 myocardial infarction AE CTCAE: E10152 HPO: HP_0001658 NCIt: C27996 SIDER: C0027051 a neutrophil count abnormal AE that has an outcome of increased neutrophil count YH 10029368 neutrophil count increased AE HPO: HP_0011991 SIDER: NA an adverse event that shows a complication that occurs after a medical procedure such as a surgery. SS, YH post-procedural AE procedural disorder AE procedure AE procedural complication AE an adverse event that has an outcome of injury after a medical intervention. SS, YH 10022116 injury AE an injury AE which has an outcome of head injury SS, YH 10019196 head injury AE a behavior and neurological AE that has an abnormal outcome in social behavior SS, YH social behavior AE a social behavior AE that has an outcome of impaired work ability SS, YH impaired work ability AE an allergy AE which has an outcome of injection-site allergic reaction 10022095 injection-site allergic reaction AE a myelitis AE which has an outcome of myelitis transverse. Transverse myelitis (in Latin nomenclature: myelitis transversa) is a neurological disorder caused by an inflammatory process of the spinal cord, and can cause axonal demyelination. SS, YH WEB: http://en.wikipedia.org/wiki/Transverse_myelitis 10028527 myelitis transverse AE a skin adverse even that has an outcome of warm skin SS, YH skin warm AE Nystagmus AE is an eye AE that is a condition of involuntary eye movement, acquired in infancy or later in life, that may result in reduced or limited vision. Due to the involuntary movement of the eye, it is often called "dancing eyes". JX, LW, YH WEB: http://en.wikipedia.org/wiki/Nystagmus 10029864 nystagmus AE CTCAE:E12748 NCIt:C3282 眼球震颤 a dermatitis AE that has an outcome of dermatitis bullous SS, YH bullous pemphigoid AE 10012441 Bullous pemphigoid is a skin disorder characterized by large blisters. dermatitis bullous AE HPO: HP_0011123 SIDER: C0085932 a skin adverse event that is characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling. SS, YH, MW hot flash AE hot flashes AE hot flush AE 10020407 hot flushes AE CTCAE: E13781 HPO: HP_0008209 NCIt: C3109 SIDER: C0600142 a KIV-induced adverse event that has an outcome of Afluria-induced adverse event YH Afluria-induced adverse event an adverse event that results in the outcome of a tumor. mass AE nodule AE tumour AE 10026865 YH, RR tumor AE a respiratory system AE which has an outcome of wheezing, a high-pitched whistling sound made while breathing. SS, YH, MW WEB: http://www.mayoclinic.org/symptoms/wheezing/basics/definition/sym-20050764 10047924 wheezing AE CTCAE:E13605 NCIt:C78718 a behavior and neurological AE that has an outcome of weight bearing difficulty weight bearing difficulty is a behavior AE that results in difficulty in managing the amount of weight a patient puts on the leg on which surgery has been performed. In general, it is described as a percentage of the body weight, because each leg of a healthy person carries the full body weight when walking, in an alternating fashion. SS, YH WEB: http://en.wikipedia.org/wiki/Weight-bearing weight bearing difficulty AE A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment. Yongqun He, Sirarat Sarntivijai, Mathias Brochhausen, William Hogan, ‎Philip E. Empey http://en.wikipedia.org/wiki/Contraindication contraindication a drug administration that uses incorrect drug dose YH incorrect drug dose administration an Afluria-induced adverse event that has an outcome of Afluria-induced fever in child YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced fever AE in child an Afluria-induced adverse event that has an outcome of Afluria-induced cough in child YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced cough AE in child an Afluria-induced adverse event which has an outcome of Afluria-induced injection site pain YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced injection site pain AE an Afluria-induced adverse event that has an outcome of Afluria-induced injection site redness YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced injection site redness AE an Afluria-induced AE that has an outcome of Afluria-induced inject site swelling YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced inject site swelling AE an Afluria-induced adverse event that has an outcome of Afluria-induced headache YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced headache AE an adverse event that occurs systematically throughout the systemic circulation. This is different from local adverse event that is limited or a certain location. YH, JX systematic adverse event URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction systematic AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with pregnancy. prenatal AE WEB: https://en.wikipedia.org/wiki/Complications_of_pregnancy WEB: https://en.wikipedia.org/wiki/Prenatal_diagnosis YH, JX pregnancy AE a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event outcome appears. This is the time = 'time instant of an adverse event outcome observed' - 'time instant of medical intervention'. YH, XZ adverse event incubation time a procedure complication AE that occurs after a surgery. YH surgery AE surgery adverse event surgical procedure AE The key difference between a surgery and a procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. Technically speaking, a surgery is a specific type of procedure. A procedure is a broad general term that refers to any series of pre-defined steps that should be followed to achieve a desired result. Therefore, a “surgical procedure” is synonymous with a “surgery.” See more: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm. surgery adverse event Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. YH, SS surgical procedure WEB: http://en.wikipedia.org/wiki/Surgery WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm 10042609 surgery a sugery adverse event that has an outcome of pressure ulcer. YH surgery-induced bedsore AE surgery-induced decubitus ulcer AE surgery-induced pressure ulcer AE an adverse event which occurs in a metabolism process (including anabolism and catabolism), endocrine system, or exocrine system. SS, YH, JX metabolism, endocrine, and exocrine system AE 10027433 metabolism, endocrine or exocrine system AE MP: 0005266 an adverse event that occurs in clinical trial. YH clinical trial adverse event a termporal instant that is the time when a medical intervention occurs. YH time instant of medical intervention time at medical intervention a temporal instant that is the time when an outcome of an adverse event (e.g., fever) is observed. YH time instant of an adverse event outcome observed an influenza vaccine adverse event that is induced by a live attenuated influenza vaccine (LAIV). YH LAIV-induced adverse event an LAIV-induced adverse event that is caused by the FluMist LAIV. YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf FluMist-induced adverse event a FluMist-induced adverse event that has an outcome of FluMist-induced runny nose YH FluMist-induced runny nose AE a FluMist-induced AE that has an outcome of FluMist-induced nasal congestion YH FluMist-induced nasal congestion AE a planned process that is specifically a test conducted in a clinical laboratory. Rebecca Racz, Yongqun He medical laboratory test WEB: http://labmed.ascpjournals.org/content/40/2/105.full clinical laboratory test A FluMist-induced AE that has an outcome of sore throat YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf FluMist-induced sore throat AE in adult a tumore AE that results in the outcome of a benign tumor. YH benign tumor AE a tumore AE that results in the outcome of a malignant tumor. YH malignant tumor AE a sensory capability AE that resuls in an uncomfortable feeling. YH discomfort AE HPO: HP_0010832 SIDER: C0234215 a reproductive system AE that occurs on the female side. YH 10038604 female reproductive system AE a reproductive system AE that occurs on the male side. YH male reproductive system AE a cardiovascular disorder AE that has a cardiac disorder outcome. SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/heart+disease Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23091623 10007541 10061024 cardiac disorder AE HPO: HP_0001627 SIDER: C0018799 a cardiovascular disorder AE that has a vascular disorder outcome 10047065 vascular disorder AE a skin adverse event that results in an inflammation of skin SS, YH 10012431 dermatitis AE HPO: HP_0011123 SIDER: C0011603 a drug adverse event that is induced by aspirin. YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced adverse event an aspirin-induced adverse event that is induced by the aspirin drug Aspidrox. Aspidrox-induced adverse event an aspirin-induced adverse event that has an outcome of nausea YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced nausea AE an aspirin-induced adverse event that has an outcome of vomiting YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced vomiting AE an aspirin-induced adverse event that has an outcome of stomach pain YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced stomach pain AE an aspirin-induced adverse event that has an outcome of heartburn YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced heartburn AE an aspirin-induced adverse event that has an outcome of rash symptom. YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced rash AE a medical intervention that is used for therapeutic purpose YH therapeutic intervention YH a drug adverse event that is caused by a drug adiministration. Here a causal effect is established between the drug administration and the adverse event. causal adverse drug event a medical device adverse event that is induced or caused by a medical device. There is a causal relation between the adverse event and the usage of a medical device. YH adverse event induced by medical device an adverse event that is induced by a vaccination. YH vaccine-induced adverse event a surgery adverse event that is caused by a surgery. YH surgery-induced adverse event YH a nutritional product adverse event that has a causal assocition with the usage of the nutritional product. nutritional product-induced adverse event influenza like illness AE is an adverse event that has an outcome of a medical diagnosis of possible influenza or other illness causing a set of common symptoms SS, YH acute respiratory infection, ARI, flu-like syndrome WEB: http://en.wikipedia.org/wiki/Influenza-like_illness 10016791 influenza like illness AE HPO: HP_0005376 MDR: 10022004 SIDER: C0521839 a prediction process that allows prediction of a causal adverse event induced by a medical intervention. YH prediction of causal adverse event a prediction of causal adverse event that is induced by a vaccination. YH prediction of causal vaccine adverse event YH a pathogen infection adverse event that has an outcome of a fungal infection. 10017533 fungal infection AE HPO: HP_0002841 SIDER: C0026946 a prediction of causal adverse event that is induced by a drug administration. YH prediction of causal drug adverse event a prediction of causal adverse event that is induced by a usage of a medical device. YH prediction of causal medical device adverse event a prediction of causal adverse event that is induced by a surgery operation. YH prediction of causal surgery adverse event a planned process that leads to the identification of a causal relation between an existing adverse event and a medical intervention. YH determination of causal adverse event an identification of causal adverse event that is induced by a vaccination. YH determination of causal vaccine adverse event an identification of causal adverse event that is induced by a drug administration. YH determination of causal drug adverse event an identification of causal adverse event that is induced by a surgery. YH determination of causal surgery adverse event an identification of causal adverse event that is induced by a usage of a medical device. YH determination of causal medical device adverse event an intrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event. YH intrinsic factor of causal adverse event an extrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event. YH extrinsic factor of causal adverse event a role that is extrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include environment, diet, smoking, alcohol use, herbal product, drug-drug interaction. YH extrinsic factor of adverse event a role that is intrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include: age, race, organ dysfunction, disease, pregrancy, lactation, gender, and genetics. YH intrinsic factor of adverse event YH an extrinsic factor of adverse event that is from environment. environment factor of adverse event YH an intrinsic factor of adverse event that is the age of a patient. age factor of adverse event YH an intrinsic factor of adverse event that is the race of a patient. race factor of adverse event YH an intrinsic factor of adverse event that is the gender of a patient. gender factor of adverse event YH an intrinsic factor of adverse event that is the organ dysfunction of a patient. organ dysfunction factor of adverse event YH an intrinsic factor of adverse event that is a disease of a patient. disease factor of adverse event YH an intrinsic factor of adverse event that is the pregrancy of a patient. pregrancy factor of adverse event YH an intrinsic factor of adverse event that is the lactation of a patient. lactation factor of adverse event YH an intrinsic factor of adverse event that is the genetics of a patient. genetics factor of adverse event a planned process that reports an adverse event. YH adverse event reporting an adverse event reporting that is to report a vaccine adverse event. YH vaccine adverse event reporting an adverse event reporting that is to report a drug adverse event. YH drug adverse event reporting YH adverse event causality a quality that represents the level of causality between a medical intervention and an adverse event outcome. causality of adverse event YH a causality level of AE that is definite. definite AE causality YH a causality level of AE that is probable. probable AE causality YH a causality level of AE that is doubtful. doubtful causality of adverse event doubtful AE causality YH a causality level of AE that is possible. possible causality of adverse event potential causality of adverse event Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20. possible AE causality an adverse event reporting that is to report a medical device adverse event. YH medical device adverse event reporting an adverse event reporting that is to report a surgery adverse event. YH surgery adverse event reporting an identification of causal drug adverse event that is based on the Naranjo criteria. YH S.R. Ahmed. Adverse drug event monitoring at the Food and Drug Administration. J. Gen. Intern. Med. 18 (2003) 57-60. determination of causal drug adverse event by Naranjo criteria an identification of causal drug adverse event that is based on the Drug Interaction Probability Scale (DIPS). The DIPS uses a series of questions relating to the potential drug interaction to estimate a probability score. As a comparison, the Naranjo scale has proved to be useful for assessing the causality of adverse events, particularly for single-drug adverse drug reactions. DIPS involves in two drugs: the drug that is affected (object drug) and the drug that causes the change to the object drug (precipitant drug). YH J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680. determination of causal drug adverse event by DIPS an information content entity that lists one of 10 questions for the Drug Interaction Probability Scale (DIPS). YH J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680. DIPS question DIPS question 1: Are there previous credible reports of this interaction in humans? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 1 DIPS question 2: Is the observed interaction consistent with the known interactive properties of precipitant drug? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 2 DIPS question 3: Is the observed interaction consistent with the known interactive properties of object drug? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 3 DIPS question 4: Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 4 DIPS question 5: Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug? (if no dechallenge, use Unknown or NA and skip Question 6) Three answers: Yes (+1), No (-2), and Unk or NA (0) YH DIPS question 5 DIPS question 6: Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug? Three answers: Yes (+2), No (-1), and Unk or NA (0) YH DIPS question 6 DIPS question 7: Are there reasonable alternative causes for the event? Three answers: Yes (-1), No (+1), and Unk or NA (0) aConsider clinical conditions, other interacting drugs, lack of adherence, risk factors (eg, age, inappropriate doses of object drug). A NO answer presumes that enough information was presented so that one would expect any alternative causes to be mentioned. When in doubt, use Unknown or NA designation. YH DIPS question 7 DIPS question 8: Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction? Three answers: Yes (+1), No (0), and Unk or NA (0) YH DIPS question 8 DIPS question 9: Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug (other than drug concentrations from question 8)? Three answers: Yes (+1), No (0), and Unk or NA (0) YH DIPS question 9 DIPS question 10: Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 10 an AE causality score that is represented as a score of the Drug Interaction Probability Scale (DIPS). Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He Drug Interaction Probability Scale Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. DIPS score YH one of the Naranjo criteria that are frequently used for determination of causality for suspected adverse drug reactions (ADRs). Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Naranjo criterium DIPS question 1: Are there previous conclusive reports on this reaction? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 1 DIPS question 2: Did the adverse reaction appear after the suspected drug was administered? Three answers: Yes (+2), No (-1), and Don't Know (0) YH Naranjo criterium 2 DIPS question 3: Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 3 DIPS question 4: Did the adverse reaction reappear when the drug was readministered? Three answers: Yes (+2), No (-1), and Don't Know (0) YH Naranjo criterium 4 DIPS question 5: Are there alternative causes that could on their own have caused the reaction? Three answers: Yes (-1), No (+2), and Don't Know (0) YH Naranjo criterium 5 DIPS question 6: Did the reaction reappear when a placebo was given? Three answers: Yes (-1), No (+1), and Don't Know (0) YH Naranjo criterium 6 DIPS question 7: Was the drug detected in the blood (or other fluids) in concentrations known to be toxic? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 7 DIPS question 8: Was the reaction more severe when the dose was increased or less severe when the dose was decreased? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 8 DIPS question 9: Did the patient have a similar reaction to the same or similar drug in any previous exposure? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 9 DIPS question 10: Was the adverse event confirmed by any objective evidence? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 10 a score of the Naranjo adverse drug reaction probability scaling SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Naranjo ADR probability score an adverse event causal association score that represents a probability that an adverse event is caused (induced) by a medical intervention. For an adverse event this is likely caused by a medical intervention, the causal adverse event (CAE) probabllity is in between 0 and 1. For a known causal adverse event, the CAE probabllity is 1. Alternatively, a CAE probability can be described as a scale that can go beyond the 0-1 range. For example, the Naranjo ADR probabililty score is a score that use scale with a wide range. YH CAE probability causal adverse event probability a peripheral neuropathy AE which has an outcome of sensory neuropathy that involves damage to nerves of the peripheral nervous system. YH, AG sensory neuropathy AE sensory neuropathy AE a sensory neuropathy AE which has an outcome of distal sensory neuropathy that involves damage to distal sensory nerves of the peripheral nervous system. YH, AG distal sensory neuropathy AE a distal sensory neuropathy AE that is chronic. YH, AG chronic distal sensory neuropathy AE a neuropathy AE that is induced by a drug administration AG, YH https://medlineplus.gov/ency/article/000700.htm drug-induced neuropathy AE Tremor AE is a behavior and neurological AE that has an outcome of an involuntary trembling or quivering, and muscle contraction and relaxation. SS, YH WEB: http://www.nlm.nih.gov/medlineplus/tremor.html 10044565 tremor AE CTCAE: E12837 HPO: HP_0001337 NCIt: C38038 SIDER: C0040822 a neuropathy AE which shows symptoms due to the damage to the autonomic nerves. This damage disrupts signals between the brain and portions of the autonomic nervous system, such as the heart, blood vessels and sweat glands. This can cause decreased or abnormal performance of one or more involuntary body functions. AG, YH WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy WEB: http://www.mayoclinic.org/diseases-conditions/autonomic-neuropathy/basics/definition/con-20029053 10061666 autonomic neuropathy AE HPO: HP_0002270 SIDER: C0259749 UMLS CUI: C0259749 a peripheral neuropathy AE which is caused by a damage to motor neurons AG, YH motor neuropathy AE A peripheral neuropathy AE which is characterized by damage to more than one nerve AG, YH, RR WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html 10036105 polyneuropathy AE HPO: HP_0001271 SIDER: C0152025 a neuropathy AE which is characterized by isolated damage of a single nerve AG, YH 10062203 mononeuropathy AE a peripheral neuropathy AE which affects extremities, such as, toes, fingers, hand and feet. AG, YH axonal neuropathy AE WEB: http://www.livestrong.com/article/184686-distal-neuropathy-symptoms/ distal neuropathy AE a nervous system AE that affects the neuronal cell body AG, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922643/ neuronopathy AE A neuritis AE which has an outcome of mononeuritis characterized by isolated inflammation of one nerve. AG, YH 10027910 mononeuritis AE A neuritis AE which has an outcome of polyneuritis characterized by isolated inflammation of many nerves. AG, YH polyneuritis AE a mononeuritis AE which has an outcome of mononeuritis multiplex which involves damage to at least two seperate unrelated nerve area. AG, YH mononeuritis multiplex AE a sensory neuropathy AE which has an outcome of acute sensory neuropathy that is characterized by rapid onset AG, YH acute sensory neuropathy AE a disposition that represents a risk factor associated with the occurrence of an adverse event. AG, YH AE risk factor A data item that is calculated as the number of patients realized with an adverse event beginning in an interval divided by the number of patients taking the same medical intervention within the same interval. The incidence thus indicates the number of newly occurring events over time. AG, YH WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf AE incidence rate a causal adverse drug event that is induced by a drug-drug interaction. YH, LT WEB: http://medical-dictionary.thefreedictionary.com/drug+interaction 10013710 causal adverse drug event due to drug-drug interaction a causal adverse drug event that is induced by a food-drug interaction. YH, LT causal adverse drug event due to food-drug interaction a causal adverse drug event that is induced bygenetic predisposition. YH, LT causal adverse drug event due to genetic predisposition a causal adverse drug event due to genetic predisposition that is specifically induced by SNP. YH, LT causal adverse drug event due to SNP a cardiovascular disorder AE that is a result of insufficient blood flow throughout the body. Shock often accompanies severe injury or illness. physiological shock AE shock WEB: http://en.wikipedia.org/wiki/Shock_%28circulatory%29 WEB: http://njcc.nl/sites/default/files/pdf/review-2_1.pdf (Lima A. Circulatory shock and peripheral circulatory failure: a historical perspective. Netherlands Journal of Critical Care. 2014. 18:6. 14-18) WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000039.htm 休克 10040560 Circulatory shock is not related to the emotional state of shock. Here is the Kumar and Parrilo definition of shock: "The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury". Reference: Kumar A, Parillo JE. Shock: pathophysiology, classification and approach to management. In: Parrillo JE, Parrillo JE, Bone RC (eds): Critical care medicine: Principles of diagnosis and management. Mosby: Toronto, 1995, pp 371-420. circulatory shock AE a psychiatric disorder AE that has an outcome of a loss of brain function and causes a long term and often gradual decrease in the ability to think and remember such that a person's daily functioning is affected. YH, MW WEB: https://en.wikipedia.org/wiki/Dementia 痴呆 10012272 Dementia is a loss of brain function that occurs with certain diseases or pathological processes. dementia AE HPO: HP_0000726 SIDER: C0497327 A vascular disorder AE that results in the presence of blood clot along the wall of a blood vessel, frequently causing vascular obstruction. Some authorities differentiate thrombus formation from simple coagulation or clot formation. SS, YH, MW 血栓症; 血栓生成 10043607 thrombosis AE HPO: HP_0004419 SIDER: C0040053 a metabolic disorder AE that has an outcome of cell death. SS, YH 10057248 cell death AE GO: GO_0008219 SIDER: C0007587 a respiratory system AE which has an outcome of some respiratory tract neoplasm. YH 10029107 respiratory tract neoplasm AE competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A YH, AG, YL biochemical inhibitor role YH, AG, YL WEB: http://en.wikipedia.org/wiki/Agonist agonist role YH, AG, YL WEB: http://en.wikipedia.org/wiki/Receptor_antagonist In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors. antagonist role an inflammation AE that shows the result of an inflammation located in a vein, usually in the legs. YH, MW 10034879 phlebitis AE CTCAE:E13815 HPO: HP_0004419 NCIt:C38003 SIDER: C0031542 a liver, biliary, and pancreatic AE that has an outcome of pancreatitis. YH, MW 10033645 10033646 pancreatitis AE CTCAE: E10930 HPO: HP_0001733 NCIt: C3306 SIDER: C0030305 a cell death AE that has an outcome of apoptosis, a form of programmed cell death that occurs in multicellular organisms. SS, YH https://en.wikipedia.org/wiki/Apoptosis 10059512 apoptosis AE a cell death AE that has an outcome of necrosis SS, YH necrosis AE HPO: HP_0003713 SIDER: C0027540 A cardiovascular disorder AE that results in Insufficient blood supply for the need of a part of the body, usually as a result of a disease of the blood vessels supplying that part. SS, YH ischaemia AE 10061255 Note: also spelt ischemia. ischemia AE HPO: HP_0002597 SIDER: C0022116 an adverse event that occurs in hair, skin, or nail. hair, skin, and nail AE YH, SS, JX hair, skin or nail AE a hair, skin, and nail AE that occurs in hair. YH, SS hair AE a hair, skin, and nail AE that occurs in nail. YH, SS nail AE a metabolism, endocrine, and exocrine system AE that occurs in endocrine system. 10014698 YH, SS endocrine system AE a metabolism, endocrine, and exocrine system AE that occurs in exocrine system YH, SS exocrine system AE an adverse event that displays a congential and genetic disorder. congenital abnormality AE 10010331 YH, SS congenital AE a muscular weakness AE that shows weakness or inability to move a body part, often used to describe a neurologic condition. WEB: https://en.wikipedia.org/wiki/Paresis 局部麻痹 10033800 Neurologists use the term paresis to describe weakness, and plegia to describe paralysis in which all voluntary movement is lost. (Reference: https://en.wikipedia.org/wiki/Paresis) paresis AE HPO: HP_0008153 SIDER: C0030552 a syndrome AE that has an outcome of cystic fibrosis, an inherited disease that affects the lungs, digestive system, sweat glands, and male fertility. YH WEB: http://medical-dictionary.thefreedictionary.com/cystic+fibrosis 10011762 cystic fibrosis AE HPO: HP_0006552 SIDER: C0010674 a tumore AE that results in the outcome of hyperplasia, an abnormal increase in the number of normal cells in normal arrangement in an organ or tissue, which increases its volume. YH, SS hyperplasia AE HPO: HP_0010279 SIDER: C0020507 an adverse event that displays a disorder in abdomen. YH, SS abdominal AE an adverse event that results in genetic disorder. genetic disorder AE YH, SS genetic AE a liver, biliary, and pancreatic AE that has an outcome of hepatitis. YH hepatitis AE HPO: HP_0006562 SIDER: C0019158 an adverse event that displays an outcome of ulcer. YH, SS ulcer AE HPO: HP_0005229 SIDER: C0041582 a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body. WEB: http://medical-dictionary.thefreedictionary.com/fistula 10067143 YH, SS fistula AE HPO: HP_0010294 SIDER: C0016169 an abnormal fluid regulation AE which has an outcome of extravasation, a discharge or escape, as of blood, from a vessel into the tissues. YH, SS WEB: http://medical-dictionary.thefreedictionary.com/extravasation 10015866 extravasation AE an adverse event that displays an outcome of an sclerosis, the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue. YH, SS sclerosis AE a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient YH 10065283 inconsolable crying AE a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient YH unusual high-pitched crying AE a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient YH prolonged crying AE a decreased heart rate AE that results in a resting heart rate of under 60 beats per minutes (BPM). WEB: http://en.wikipedia.org/wiki/Bradycardia WEB: http://medical-dictionary.thefreedictionary.com/bradycardia 10006093 bradycardia AE HPO: HP_0001662 SIDER: C0428977 an adverse event that displays a disorder associated with child birth, newborn infant, or an infant. pregnancy, neonatal and perinatal disorder AE 10036585 YH, JX prenatal, perinatal or neonatal disorder AE an errored drug administration where a patient is administered with an ineffective drug YH administration of ineffective drug an errored drug administration where a patient is administered with an ctive drug with decreased effectiveness YH administration of drug with decreased effectiveness a bupropion-induced adverse event that is induced by aplenzin administration YH aplenzin-induced adverse event an errored drug administration where a patient is administered with a drug above the therapeutic level YH drug overdose administration an errored drug administration where a patient is administered with an drug without knowing the dose used. YH administration of drug with omitted dose a quality that represents resistance of a patient to a drug. YH drug resistance an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site). YH application site reaction 10003055 medical intervention site AE a site that is used for a medical intervention YH medical intervention site an errored drug administration where a patient is administered with an drug stored in capsule with physical defect YH administration of drug stored in capsule with physical defect an errored drug administration where a patient is administered with an drug with wrong technique YH 10064353 administration of drug with wrong technique a drug administration where a patient is administered with an drug with incorrect route YH 10064304 administration of drug with incorrect route A pregnancy, neonatal and perinatal AE that displays a disorder associated with newborn infant or an infant. YH neonatal AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with childbirth YH perinatal AE a medical intervention that has an errored medication YH 10027091 errored medication a medical intervention that has errored drug medication SS, YH 10064355 errored drug administration a therapeutic intervention that uses radiation YH radiotherapy a vascular disorder AE that affects the artery SS arterial disease AE arterial disorder AE HPO: HP_0002620 SIDER: C0852949 an artery disorder AE that is characterized by a narrowing of the blood vessels outside of the heart. SS peripheral artery disease AE peripheral artery disorder AE WEB: http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=peripheral+arterial+disease 10067825 peripheral arterial disease AE HPO: HP_0004950 SIDER: C1704436 an autoimmune disease AE that shows a symptom of dry red patches on the skin. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/psoriasis WEB: https://en.wikipedia.org/wiki/Psoriasis 10037153 psoriasis AE HPO: HP_0003765 SIDER: C0033860 a distal sensory neuropathy AE characterized by an increase in degree (cumulative) AG, YH cumulative distal sensory neuropathy AE a behavior and neurological AE that has an outcome of stress in a patient YH stress AE an abscess AE that has an outcome of a pocket of infected fluid and pus located inside the abdominal cavity DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000212.htm 10060921 abdominal abscess AE a discomfort AE that has an outcome of a stomach ache DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Abdominal+discomfort 10000059 abdominal discomfort AE HPO: HP_0002027 SIDER: C0232487 a sensory capability AE that results in a sensation of elevated abdominal pressure and volume DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0003609/ 10000060 abdominal distension AE CTCAE: E10456 HPO: HP_0003270 NCIt: C78161 SIDER: C0000731 a sepsis AE that has an outcome of sepsis in the abdominal area DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001687/ 10058040 abdominal sepsis AE an abdominal abscess AE that has an outcome of a collection of pus in the abdominal wall, causes inflammation DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002329/ 10000099 abdominal wall abscess AE a behavioral AE that results in uncharacteristic behaviors 12/19/2015: This term became obsolete since its meaning can be quite confusing. "behavior AE" is now considered as the synonym of 'behavioral and neurological AE'. DJ, SS, YH abnormal behavior AE abnormal behaviour AE behavioral AE 10061422 obsolete: behavior AE HPO: HP_0000708 SIDER: C0233514 a behavioral and neurological AE that results in odd dreams DJ, SS, YH 10000125 abnormal dreams AE an abortion AE that has an outcome of expulsion of a fetus from the uterus brought on intentionally by medication or instrumentation DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/induced+abortion 10000220 abortion induced AE an abortion AE that results in a miscarriage DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002458/ 10000234 abortion spontaneous AE HPO: HP_0005268 SIDER: C0000786 a skin AE that is characterized by pimples generally on the face, chest and back, caused by clogging of the pores DJ, SS, YH acne vulgaris AE WEB: http://medical-dictionary.thefreedictionary.com/acne 10000496 acne AE HPO: HP_0001061 SIDER: C0702166 a immune system disorder AE that is caused by the HIV virus DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/hivaids.html 10000565 acquired immunodeficiency syndrome AE HPO: HP_0002721 SIDER: C0001175 a hematopoietic system AE that has an outcome of a prolonged time taken for blood to clot. The partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. PTT measures the efficacy of the comon coagulation pathways and helps tell if bleeding or clotting problems exist. DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm 10000636 activated partial thromboplastin time prolonged AE CTCAE: E12073 HPO: HP_0003645 NCIt: C27028 SIDER: C0853223 a digestive system AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the intestine attack the transplant recipient's body DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm 10066264 acute graft versus host disease in intestine AE a skin AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the skin attack the transplant recipient's body DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm 10066262 acute graft versus host disease in skin AE a hematopoietic system AE that has an outcome of a type of acute leukemia, characterized by anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, and bone pain DJ, SS, YH acute lymphocytic leukaemia AE WEB: http://medical-dictionary.thefreedictionary.com/Blast+count 10000846 acute lymphocytic leukemia AE HPO: HP_0006721 SIDER: C0023449 a hematopoietic system AE that has an outcome of the reoccurance of fast-growing cancer of the white blood cells where abnormal blasts do not fight infections after a period of remission DJ, SS, YH acute lymphocytic leukaemia recurrent AE WEB: http://marrow.org/Patient/Disease_and_Treatment/About_Your_Disease/ALL/Acute_Lymphoblastic_Leukemia_(ALL).aspx 10063620 acute lymphocytic leukemia recurrent AE a hematopoietic system AE that has an outcome of cancer in the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells DJ, SS, YH acute myeloid leukaemia AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/ 10000880 acute myeloid leukemia AE HPO: HP_0004808 SIDER: C0023467 an acute myeloid leukemia AE that shows an recurrence of acute myeloid leukemia DJ, SS, YH acute myeloid leukaemia recurrent AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/ 10059034 acute myeloid leukemia recurrent AE a lung disorder AE that has the outcome fluid accumulation in the air spaces and parenchyma of the lungs with rapid onset DJ, SS, YH acute pulmonary oedema AE WEB: http://medical-dictionary.thefreedictionary.com/Acute+pulmonary+edema 10001029 acute pulmonary edema AE HPO: HP_0100598 SIDER: C0155919 a respiratory distress AE that prevents enough oxygen from getting to the lungs and into the blood DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001164/ 10001052 acute respiratory distress syndrome AE HPO: HP_0002093 SIDER: C0035222 a lung disorder AE that has an outcome of a condition in which not enough oxygen passes from the lungs into the blood, with rapid onset DJ, SS, YH, MW WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/rf/ 10001053 acute respiratory failure AE HPO: HP_0002093 SIDER: C0264490 a syncope AE that results in sudden episodes of fainting and sometimes seizures DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518479/ 10001115 adams-stokes syndrome AE a reproductive system AE that results in the thickening of the walls of the uterus. This ccurs when endometrial tissue, which normally lines the uterus, moves into the outer muscular walls of the uterus. DJ, SS, YH endrometriosis interma AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002481/ 10056268 adenomyosis AE a viral infection that occurs in the respiratory system and has an outcome of viral infection by nonenveloped icosahedral viruses causing illness in the respiratory system DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Adenovirus+Infections 10060931 adenovirus infection AE HPO: HP_0004429 SIDER: C0001486 a tumor AE that results in an abnormal number of cells proliferating on the kidney(s) DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22486993 10061588 adrenal neoplasm AE an endocrine system AE that results in the suppression of the functions of the adrenal glands DJ, SS, YH 10001382 adrenal suppression AE a behavior and neurological AE that results in an increase in hostile behavior DJ, SS, YH 10001488 aggression AE HPO: HP_0000718 SIDER: C0001807 a hematopoietic system AE that has an outcome of acute leukopenia, or lowered white blood cell count, most commonly of neutrophils causing neutropenia in circulating blood JX, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001295.htm 粒性白血球缺乏症 10001507 agranulocytosis AE HPO: HP_0001913 SIDER: C0001824 an embolism AE that is caused by an air bubble in the vessel DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23295634 10001526 air embolism AE a liver related investigation result abnormal AE that has an outcome of an abnormal blood level of alanine aminotransferase DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 10001547 alanine aminotransferase level abnormal AE an alanine aminotransferase level abnormal AE that has an outcome of a decrease in alanine aminotransferase level in body DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 10001549 alanine aminotransferase level decreased AE an alanine aminotransferase level abnormal AE that has an outcome of elevated levels of alanine transaminase, an enzyme most commonly found in the liver DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 10001551 alanine aminotransferase level increased AE CTCAE: E12077 NCIt: C26948 a liver/biliary system AE that is characterized by liver disease caused by the patient's alcoholic activity DJ, SS, YH 10001627 alcoholic liver disease AE a behavior and neurological AE that has an outcome of significantly different waking beta wave state DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/20182997 10001854 altered state of consciousness AE a female reproductive system AE that is characterized by the absence of menstrual period in a woman of reproductive age DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21942684 10001928 amenorrhoea AE HPO: HP_0000141 SIDER: C0002453 an abnormal fluid regulation AE that results in a decreased volume of amniotic fluid during pregnancy DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22039031 10063356 amniotic fluid volume decreased AE an anus AE that has an outcome of a split or tear in the mucosa lining the lower rectum DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002116/ 10002153 anal fissure AE HPO: HP_0004378 SIDER: C0016167 an ulcer AE that has an outcome of an ulcer in the anal cavity DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/17073250 10002180 anal ulcer AE CTCAE: E10496 NCIt: C79536 a vascular disorder AE that has an outcome of a leakage at the site of the intersection of two blood vessels DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23122582 10050456 anastomotic leak AE a cardiac disorder AE that is stable and shows the symptom of a chest pain due to ischemia of the heart DJ, SS, YH stable angina AE WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Angina-Pectoris-Stable-Angina_UCM_437515_Article.jsp# WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723 10002383 angina pectoris AE HPO: HP_0001681 SIDER: C0002962 a angina AE that is unstable and has an outcome of a condition in which the heart doesn't get enough blood flow through the blood vessels of the heart muscle, may lead to heart attack. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001250/ 10002388 angina unstable AE HPO: HP_0001681 SIDER: C0002965 an immunology and allergy investigation result abnormal AE that is characterized by antibodies present that are against cell-membrane phospholipids that provoke blood clots DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23231732 10048678 antiphospholipid antibodies positive AE a urinary system AE that has an outcome of the absence of urine formation DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/anuria 10002847 anuria AE HPO: HP_0100519 SIDER: C0003460 a vascular disorder AE that results in a condition affecting the aorta and aortic valves DJ, SS, YH WEB: http://www.rightdiagnosis.com/medical/aorta_disorder.htm 10058648 aortic disorder AE HPO: HP_0001679 SIDER: C0003493 a cardiac valve disease AE that has an outcome of inability of the aortic valve to function effectively DJ, SS, YH WEB: http://www.rightdiagnosis.com/a/aortic_valve_incompetence/intro.htm 10002915 aortic valve incompetence AE HPO: HP_0001659 SIDER: C0003504 a congenital abnormality AE with an outcome of defective development or congenital absense of an organ or tissue DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/737831 10002961 aplasia AE HPO: HP_0010515 SIDER: C0243065 Aplastic anaemia AE is an anemia AE that occurs when the bone marrow, and the blood stem cells that reside there are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). DJ, SS, JX, YH aplastic anemia WEB: http://www.ncbi.nlm.nih.gov/pubmed/23292240 再生障碍性贫血 10002967 aplastic anaemia AE HPO: HP_0001915 SIDER: C0002874 a serious AE that is due to an allergic brochospasm, which causes a serious problem with breathing and requires treatment in an emergency room. YH, JX URL: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm URL: https://en.wikipedia.org/wiki/Bronchospasm allergic brochospasm AE that requires treatment in emergency a hypersensitivity AE that occurs at the site of an application of a medical intervention (e.g., drug administration or vaccination). DJ, SS, YH 10063683 application site hypersensitivity AE an infection AE that occurs at the site of drug application DJ, SS, YH 10049041 application site infection AE a hemorrhage AE that has an outcome of bleeding in the arteries DJ, SS, YH arterial bleeding AE arterial haemorrhage AE 10060964 arterial hemorrhage AE CSF protein increased AE is an abnormal cerebrospinal fluid production that results in and increase in blood level CSF protein SS, YH 10011575 CSF protein increased AE a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of an abnormal result in the cerebrospinal fluid (CSF) collection test that examines the fluid that surrounds the brain and spinal cord This should be inferred as a "AE: lab test abnormal". SS, YH, EB WEB: www.nlm.nih.gov/medlineplus/ency/article/003428.htm 10059703 CSF test result abnormal AE Henoch-Schonlein purpura AE is a purpura AE, a systemic vasculitis (inflammation of blood vessels) characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney. This results from some allergic response, SS, YH allergic purpura, anaphylactoid purpura, vascular purpura WEB: http://en.wikipedia.org/wiki/Henoch-Schonlein_purpura 10019617 Henoch-Schonlein purpura AE HPO: HP_0000979 SIDER: C0034152 SS, YH WEB: http://en.wikipedia.org/wiki/Abasia 10049460 a movement disorder AE that has an outcome of abasia, a movement disorder that results in and inability to walk due to impaired muscle coordination abasia AE HPO: HP_0002540 SIDER: C0877217 a stomach pain AE that is observed in upper stomach SS, YH 10000087 abdominal pain upper AE HPO: HP_0002027 SIDER: C0232492 a behavior and neurological AE that has an outcome of loss of taste functions of the tongue, particularly the inability to detect sweetness, sourness, bitterness, saltiness, and umami (the taste of monosodium glutamate). SS, YH WEB: http://en.wikipedia.org/wiki/Ageusia 10001480 ageusia AE a sensory neuropathy AE that has an outcome of chronic sensory neuropathy characterized by being persistent or long-lasting in nature AG, YH chronic sensory neuropathy AE a behavior and neurological AE that has an outcome of a lack of functioning olfaction, an inability to perceive odors SS, YH WEB: http://en.wikipedia.org/wiki/Olfaction 10002653 anosmia AE HPO: HP_0010632 SIDER: C0003126 a psychiatric disorder AE that has an outcome of a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry. SS, YH WEB: http://en.wikipedia.org/wiki/Anxiety 10002855 anxiety AE CTCAE: E12883 HPO: HP_0000739 NCIt: C26696 SIDER: C0003467 an arrhythmia AE that is characterized by rapid regular atrial contractions occurring usually at rates between 250 and 400 per minute and often producing saw-tooth waves in an electrocardiogram. SS AF auricular flutter WEB: http://medical-dictionary.thefreedictionary.com/atrial+flutter 10003662 atrial flutter AE CTCAE: E10087 HPO: HP_0004749 NCIt: C51224 SIDER: C0004239 a behavior and neurological AE that has an outcome of a disturbance that causes an individual to feel unsteady, giddy, woozy, or have a sensation of movement, spinning, or floating. SS, YH WEB: http://en.wikipedia.org/wiki/Balance_disorder 10049848 balance disorder AE HPO: HP_0002141 SIDER: C0575090 blister AE is a skin adverse event that results in a small pocket of fluid within the upper layers of the skin SS, YH WEB: http://en.wikipedia.org/wiki/Blister 10005191 blister AE HPO: HP_0008066 SIDER: C0005758 cellulitis AE is an inflammation AE that is a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin SS, YH WEB: http://en.wikipedia.org/wiki/Cellulitis 10007882 cellulitis AE HPO: HP_0003553 SIDER: C0007642 a behavior and neurological AE that has an outcome of a type of perspiration usually associated with anxiety or fear SS, YH WEB: http://en.wikipedia.org/wiki/Cold_sweat cold sweat AE convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body SS, YH WEB: http://en.wikipedia.org/wiki/Convulsion 10010904 convulsion AE HPO: HP_0001250 SIDER: C0009951 SS, YH a movement disorder AE that has an outcome of difficulty in walking properly difficulty in walking AE a behavior and neurological AE that has an outcome of distortion of the sense of taste SS, YH, MW WEB: http://en.wikipedia.org/wiki/Dysgeusia 10013911 dysgeusia AE CTCAE:E12643 HPO: HP_0000223 NCIt:C28145 SIDER: C0013378 a movement disorder AE that has an outcome of dyskinesia SS, YH WEB: http://en.wikipedia.org/wiki/Dyskinesia 10013916 dyskinesia is a movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements dyskinesia AE HPO: HP_0100660 SIDER: C0013384 An abnormal respiration AE that is characterized by a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity. MedDRA: 10013968 is for "dyspnoea"; MedDRA: 10013963 is for "dyspnea". SS, YH air hunger dyspnoea shortness of breath WEB: http://en.wikipedia.org/wiki/Dyspnoea https://en.wikipedia.org/wiki/Shortness_of_breath https://www.mayoclinic.org/symptoms/shortness-of-breath/basics/definition/sym-20050890 呼吸困难 10013963 10013968 dyspnea AE CTCAE: E13368 HPO: HP_0002094 NCIt: C2998 SIDER: C0013404 UMLS CUI: C0013404 SS, YH, EB WEB: http://en.wikipedia.org/wiki/Electromyography 10014431 a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of abnormal activity in skeletal muscles evaluted and measured by electromyography electromyogram result abnormal AE eye irritation AE is an eye disorder AE that results in mild eye redness, itching, or tearing SS, YH WEB: http://www.freemd.com/eye-irritation/ 10015946 eye irritation AE HPO: HP_0000478 SIDER: C0235266 eye pruritus AE is a pruritus AE (an unpleasant sensation that evokes the desire or reflex to scratch) at the eye area SS, YH 10052140 eye pruritus AE HPO: HP_0000989 SIDER: C0022281 glomerulonephritis AE is a kidney disorder AE that results in a renal disease that is characterized by inflammation of the glomeruli, or small blood vessels in the kidneys. SS, YH glomerular nephritis AE WEB: http://en.wikipedia.org/wiki/Glomerulonephritis glomerulonephritis AE HPO: HP_0000099 SIDER: C0017658 A conduction system disorder AE that is a condition in which the electrical impulse from the bundle of His to the ventricles is delayed or fails to conduct along the right bundle branch, resulting in right ventricular depolarization by cell-to-cell conduction spreading from the interventricular septum and left ventricle to the right ventricle–ie, slow and uncoordinated Natural history Surgically induced RBBB has few acute hemodynamic consequences and a generally benign course long term; rarely, progression to complete heart block and sudden death occur, especially if accompanied by major His-Purkinje system–eg, left anterior hemiblock, first-degree AV block–injury; tetralogy of Fallot repair with an RBBB and a markedly prolonged QRS duration >180 ms have an ↑ risk for ventricular arrhythmias and sudden death. SS RBBB right bundle branch block WEB: http://medical-dictionary.thefreedictionary.com/right+bundle+branch+block 10006582 bundle branch block right AE HPO: HP_0011712 SIDER: C0085615 a cardiac disorder AE of the electrical conduction system that controls the heart rate, generates and conducts electrical impulses throughout the muscle of the heart, stimulating the heart to contract and pump blood. SS cardiac conduction disorder AE conduction disorder AE WEB: http://www.medterms.com/script/main/art.asp?articlekey=8407 10000032 10010276 conduction system disorder AE CTCAE: E10114 NCIt: C78245 a sensory capability AE that has an outcome of hypoaesthesia, meaning that skin loses some of its sensitivity to pain or touch SS, YH disesthesia AE hypoaesthesia AE WEB:http://medguides.medicines.org.uk/document.aspx?name=hypoaesthesia 10020937 hypoesthesia AE HPO: HP_0010830 SIDER: C0020580 a thrombosis AE that has an outcome of a blood clot within an artery [SS] Per DRA and KKB's comment, arterial thrombosis may also be characterized as an embolism. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23236330 10003178 arterial thrombosis AE HPO: HP_0004420 SIDER: C0151942 a viral infection AE that demonstrates an influenza viral infection. Influenza is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals SS, YH WEB: http://en.wikipedia.org/wiki/Influenza influenza AE HPO: HP_0005376 MDR: 10022000 SIDER: C0021400 a coronary artery disease AE with the outcome hardening of the coronary artery due to a build up of waxy plaque on the inside of blood vessels DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Coronary+Arteriosclerosis 10003211 arteriosclerosis coronary artery AE HPO: HP_0004929 SIDER: C0010054 injected limb mobility decreased AE is a mobility decreased AE that occurs in the limb in which injection is administered SS, YH injected limb mobility decreased AE a haematoma AE that has an outcome of injection-site haematoma, which results in a collection of blood outside the blood vessels at the physical area of injection SS, YH injection-site haematoma AE WEB: http://medical-dictionary.thefreedictionary.com/hematoma http://en.wikipedia.org/wiki/Hematoma 10022066 injection-site hematoma AE injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site SS, YH WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration injection-site induration AE injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection SS, YH WEB: http://en.wikipedia.org/wiki/Itch WEB: http://medical-dictionary.thefreedictionary.com/pruritus 10022093 injection-site pruritus AE injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site SS, YH WEB: http://en.wikipedia.org/wiki/Rash injection-site rash AE injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site SS, YH injection-site warmth AE A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm 10023232 joint swelling AE HPO: HP_0005833 SIDER: C0152031 an adverse event that occurs in kidney. SS, YH, DA abnormal renal function AE renal disorder AE https://medlineplus.gov/ency/article/001265.htm 10038428 kidney AE a behavior and neurological AE that has an outcome of an increase in production, secretion, and shedding of tears SS, YH WEB: http://en.wikipedia.org/wiki/Tears WEB: http://www.medterms.com/script/main/art.asp?articlekey=6199 10023644 lacrimation increased AE HPO: HP_0009926 SIDER: C0152227 lip swelling AE is an edema (swelling) AE that results in enlargement or protuberance in the lip SS, YH WEB: http://en.wikipedia.org/wiki/Swelling_%28medical%29 10024570 lip swelling AE HPO: HP_0000159 SIDER: C0240211 A lymphadenopathy AE that results in swollen/enlarged lymph nodes SS, YH WEB: http://en.wikipedia.org/wiki/Lymphadenopathy lymphadenitis AE HPO: HP_0002840 SIDER: C0024205 mobility decreased AE is a nervous system AE that results in difficulty in movement leading to less ability to move part(s) of body SS, YH 10048334 mobility decreased AE HPO: HP_0006217 SIDER: C0700572 a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength). SS, YH WEB: http://en.wikipedia.org/wiki/Muscular_weakness 10028372 muscular weakness AE HPO: HP_0001324 SIDER: C0151786 a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton SS, YH 10052904 musculoskeletal stiffness AE HPO: HP_0003552 SIDER: C0948525 nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels SS, YH WEB: http://en.wikipedia.org/wiki/Nasal_congestion 10028735 nasal congestion AE CTCAE: E13450 HPO: HP_0001742 NCIt: C78500 SIDER: C0027424 a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system SS, YH common cold AE WEB: http://en.wikipedia.org/wiki/Nasopharyngitis nasopharyngitis AE HPO: HP_0002087 SIDER: C0027441 an neuropathy AE that results in a damage to the peripheral nervous system (PNS, outside the brain and spinal cord), the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body. SS, YH neuropathy peripheral AE WEB: http://en.wikipedia.org/wiki/Peripheral_neuropathy WEB: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm 10029331 peripheral neuropathy AE ocular hyperaemia AE is an eye disorder AE that results in severe redness and irritation of the eyes SS, YH ocular hyperaemia AE WEB: http://www.med.miami.edu/news/view.asp?id=259 10030041 ocular hyperemia AE a pain AE that has an outcome of oropharyngeal pain SS, YH WEB: http://en.wikipedia.org/wiki/Oropharyngeal_airway 10068319 oropharyngeal pain is a pain in oral airway oropharyngeal pain AE HPO: HP_0010833 SIDER: C2363731 an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection SS, YH WEB: http://en.wikipedia.org/wiki/Otitis_media 10033078 otitis media AE CTCAE: E11477 HPO: HP_0008623 NCIt: C34885 SIDER: C0029882 an inflammation AE that has an outcome of pericaditis, which is a cardiovascular disorder that results in a condition in which the sac-like covering around the heart (pericardium) becomes inflamed SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000182.htm 10034484 pericarditis AE CTCAE: E10180 HPO: HP_0001701 NCIt: C34915 SIDER: C0031046 pharyngeal edema AE is an edema AE that results in an bbnormal fluid accumulation in TISSUES or body cavities in pharynx (throat swelling). SS, YH pharyngeal oedema AE WEB: http://www.ncbi.nlm.nih.gov/mesh/68004487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Mesh.Mesh_ResultsPanel.Mesh_RVDocSum pharyngeal edema AE pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx SS, YH WEB: http://en.wikipedia.org/wiki/Pharyngitis 10034835 pharyngitis AE CTCAE: E11525 HPO: HP_0100776 NCIt: C26851 SIDER: C0031350 a pain AE that shows a pain in sinus and throat SS, YH, MW WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/ 10034844 pharyngolaryngeal pain AE CTCAE: E13482 HPO: HP_0010833 NCIt: C78556 SIDER: C0858635 rash macular AE is a rash AE that results in a skin eruption in which the lesions are flat and less than 1 cm in diameter SS, YH rash macular AE WEB: http://medical-dictionary.thefreedictionary.com/macular+rash macular rash AE HPO: HP_0000988 SIDER: C0221201 a rash AE that shows clustered papules, i.e., small, round, raised bumps that have clear borders. SS, YH rash papular AE WEB: http://en.wikipedia.org/wiki/Rash WEB: http://www.healthline.com/symptom/papule WEB: http://www.rightdiagnosis.com/sym/papular_rash.htm 10037876 papular rash AE HPO: HP_0007432 SIDER: C0221202 A respiratory system AE thta is characterized by inflammation of the lung parenchyma leading to impaired gas exchange with concomitant systemic release of inflammatory mediators causing inflammation, hypoxemia and frequently resulting in multiple organ failure. SS, YH WEB: http://en.wikipedia.org/wiki/Acute_respiratory_distress_syndrome 10038687 respiratory distress AE HPO: HP_0002747 SIDER: C0476273 respiratory tract congestion AE is a respiratory system AE that results in congestion in respiratory tract SS, YH respiratory tract congestion AE retching AE is a digestive system AE that results in a process in the human body where gastric (and sometimes duodenal) contents are forced into the esophagus, but do not enter the pharynx SS, YH WEB: http://en.wikipedia.org/wiki/Retching 10038776 retching AE rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose SS, YH runny nose WEB: http://en.wikipedia.org/wiki/Rhinitis WEB: http://medical-dictionary.thefreedictionary.com/rhinitis 10028116 rhinitis AE HPO: HP_0002257 SIDER: C0035455 rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid SS, YH rhinorrhoea AE WEB: http://en.wikipedia.org/wiki/Rhinorrhoea rhinorrhea AE a pain AE that occurs in shoulder shoulder pain is a pain iin or around the shoulder joint SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003171.htm shoulder pain AE sinus congestion AE is a nasal congestion AE that results in blockage of the air cavities in the cranial bones or nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels SS, YH WEB: http://en.wikipedia.org/wiki/Sinus_%28anatomy%29, http://en.wikipedia.org/wiki/Nasal_congestion sinus congestion AE HPO: HP_0002257 SIDER: C0152029 sneezing AE is a respiratory system adverse event that results in sternutation, a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa SS, YH, MW sternutation WEB: http://en.wikipedia.org/wiki/Sneezing 10041232 sneezing AE CTCAE:E13572 NCIt:C50746 an increased heart rate AE where the heart rate exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual) SS, YH WEB: http://en.wikipedia.org/wiki/Tachycardia 10043071 tachycardia AE HPO: HP_0001649 SIDER: C0039231 a tendon disorder AE that has an outcome of tendonitis SS, YH tendinitis AE WEB: http://en.wikipedia.org/wiki/Tendinitis tendonitis is a tendon disorder that results in an inflammation of a tendon tendonitis AE HPO: HP_0100261 SIDER: C0039503 a sensory capability AE that has an outcome of a sensation of tightness in the throat 10043528 throat tightness AE an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx SS, YH URI, URTI WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection 10046300 upper respiratory tract infection AE CTCAE: E11604 HPO: HP_0002788 NCIt: C35650 SIDER: C0041912 a viral infection AE that results in an acute contagious diseased caused by herpes varicella zoster virus; causes a rash of vesicles on the face and body. SS, YH chicken pox AE varicella zoster virus infection AE WEB: http://wordnetweb.princeton.edu/perl/webwn?s=varicella varicella AE HPO: HP_0005428 SIDER: C0008049 a paresthesia AE that occurs in oral area. SS, YH paraesthesia oral AE http://www.answers.com/topic/oral-paresthesia 10057372 paraesthesia oral is a paresthesia that results in a numbness or tingling that occurs in the mucosa or tissues of the oral cavity. paresthesia oral AE HPO: HP_0003401 SIDER: C0521591 an abnormal body temperature AE which has an outcome of fever YH, SS, MW body temperature increased AE febrile response pyrexia AE Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. WEB: http://en.wikipedia.org/wiki/Pyrexia 10005911 10016558 10037660 Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °F). fever AE CTCAE: E11102 NCIt: C3038 a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. YH URL: http://en.wikipedia.org/wiki/Rash URL: http://www.webmd.com/skin-problems-and-treatments/guide/common-rashes Wick JY. Drug-induced rash: nuisance or threat? Consult Pharm. 2013 Mar;28(3):160-6. PMID: 23462025. 10037844 Drug-induced rash is the most commonly reported drug reaction. rash AE HPO: HP_0000988 SIDER: C0015230 an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite. change of name from 'infection adverse event' to 'infectious adverse event' on 09/23/13 for a better clinical relevance, move 'infection adverse event' as an alternative term - SS YH, JX infectious adverse event WEB: http://medical-dictionary.thefreedictionary.com/infection infection 10021789 infection AE An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. YH syndrome AE a psychiatric disorder AE that has an outcome of emotional state of excitement or restlessness YH, MW 10001497 agitation AE CTCAE:E12874 HPO: HP_0000711 NCIt:C79530 SIDER: C0085631 injection-site AE is an AE that occurs in an injection site (e.g., during vaccination). YH, JX, SS injection site AE injection-site adverse event injection-site reaction local reaction AE 10022095 injection-site AE CTCAE: E11138 NCIt: C3508 a hypersensitivity AE which has an outcome of injection-site hypersensitivity YH injection-site hypersensitivity AE an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found. YH, RR injection-site oedema AE injection-site swelling AE WEB: http://www.uptodate.com/contents/edema-swelling-beyond-the-basics 10053425 injection-site edema AE a pain AE that occurs in an injection site of a medical intervention YH 10022086 injection-site pain AE an inflammation AE which has an outcome of injection-site inflammation YH injection-site inflammation AE a hemorrhage AE that has an outcome of injection-site hemorrhage YH 10022067 injection-site hemorrhage AE a tumor or mass AE that occurs in an injection-site YH, SS injection site nodule AE injection-site mass is a mass at physical injection site injection-site mass AE a skin adverse event that has an outcome of pruritus YH, SS, MW itch itching pruritus generalised AE WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity 10037087 Pruritus is an itch (Latin: pruritus), i.e., an unpleasant sensation that evokes the desire or reflex to scratch. pruritus AE CTCAE:E13686 HPO: HP_0000989 NCIt:C3344 SIDER: C0033774 a sensory capability AE that has an outcome of pain in a patient YH, MW 10033371 pain AE CTCAE: E11167 HPO: HP_0010833 NCIt: C3303 SIDER: C0030193 a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders. YH, MW muscle pain AE 10028411 myalgia AE CTCAE:E12485 HPO: HP_0003326 NCIt:C27009 SIDER: C0231528 Urticaria AE is a rash AE notable for dark red, raised, itchy bumps. YH, MW hives 10046735 urticaria AE CTCAE:E13746 HPO: HP_0001025 NCIt:C3432 SIDER: C0042109 a pain AE that has an outcome of headache YH, MW 10019211 headache AE CTCAE: E12678 HPO: HP_0002315 NCIt: C34661 SIDER: C0018681 an AE that occurs in respiratory system. I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He YH respiratory system AE a leukocyte cell number abnormal AE that has an outcome of greater than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). SS, YH, EB increased leukocyte cell number AE leukocytosis AE white blood cell count increased AE WEB: http://en.wikipedia.org/wiki/Leukocytosis 10024378 10047943 leukocyte cell number increased AE CTCAE: E10048 MP: MP_0000218 NCIt: C35524 a leukocyte cell number abnormal AE that has an outcome of reduction in the number of leukocytes, or of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). decreased leukocyte cell number AE white blood cell count decreased AE 10047942 leukocyte cell number decreased AE CTCAE: E12232 MP: MP_0000221 NCIt: C26816 a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries abnormal blood pressure AE MP: MP_0000230 a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength. YH 10003549 asthenia AE HPO: HP_0001324 SIDER: C0004093 a muscle pain AE that has an outcome of muscle ache. YH muscle ache AE A rash AE that shows a flat, red area on the skin overed with small confluent bumps. YH, MW maculopapular rash AE rash maculo-papular AE rash maculopapular AE WEB: http://en.wikipedia.org/wiki/Maculopapular_rash 10037868 The term "maculopapular" is a compound: macules are small, flat discolored spots on the surface of the skin; and papules are small, raised bumps. maculo-papular rash AE CTCAE:E13700 NCIt:C75579 An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. YH, MW 10003239 arthralgia AE CTCAE:E12374 HPO: HP_0002829 NCIt:C50464 SIDER: C0003862 vesiculobullous rash AE is a rash AE characterized by serous-fluid-filled vesicles (blisters) YH vesiculobullous rash AE HPO: HP_0000988 SIDER: C0151883 a syndrome AE which has an outcome of screaming syndrome YH screaming syndrome AE a sensory capability AE that has an outcome of dizziness YH, SS, MW 10013573 Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. dizziness AE CTCAE:E12631 HPO: HP_0002321 NCIt:C37943 SIDER: C0012833 peripheral edema AE is an edema AE that results in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids YH, SS edema peripheral AE oedema peripheral AE peripheral edema AE WEB: http://en.wikipedia.org/wiki/Peripheral_edema 10030124 10050068 edema limbs AE CTCAE: E11086 NCIt: C78262 a sensory capability AE that has an outcome of malaise YH 10025482 Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. malaise AE CTCAE: E11152 HPO: HP_0002321 NCIt: C3832 SIDER: C0231218 a behavior and neurological AE that has an outcome of somnolence YH, SS, MW drowsiness 10041349 Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). somnolence AE CTCAE:E12814 HPO: HP_0001262 NCIt:C26754 SIDER: C2830004 a sensory neuropathy AE that shows a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect. YH, MW paraesthesia AE WEB: http://en.wikipedia.org/wiki/Paraesthesia 10033775 10033987 Paresthesia is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic. paresthesia AE CTCAE: E12758 NCIt: C28177 a behavior and neurological AE that has an outcome of abnormal crying in a patient YH 10011469 crying abnormal AE a sensory capability AE that has an outcome of chills YH feeling cold AE 10008531 Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. chills AE CTCAE: E11074 HPO: HP_0001945 NCIt: C35143 SIDER: C0085593 a behavior and neurological AE that has an outcome of stupor YH 10042264 Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization. stupor AE HPO: HP_0004372 SIDER: C0085628 a gustatory system AE which demonstrates a decreased sensation of appetite. YH, MW anorexia nervosa AE decreased appetite AE WEB: http://www.mayoclinic.org/diseases-conditions/anorexia/basics/definition/con-20033002 厌食症 10002646 10002649 10061428 anorexia AE CTCAE: E12252 HPO: HP_0002039 NCIt: C2875 SIDER: C0003123 face edema AE is an edema AE that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms YH, SS, MW emema face AE face oedema AE oedema face AE WEB:http://www.nlm.nih.gov/medlineplus/ency/article/003105.htm swelling face 10014222 10016029 10042682 face edema AE CTCAE: E11082 NCIt: C78289 an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear YH, SS, MW coughing AE WEB: http://medical-dictionary.thefreedictionary.com/cough WEB: http://www.nlm.nih.gov/medlineplus/cough.html cough 10011224 cough AE CTCAE:E13364 NCIt:C37935 a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention. YH flu-like symptom AE flu syndrome AE CTCAE: E11108 NCIt: C78302 a sensory capability AE that has an outcome of loss of consciousness, fainting YH, SS, MW Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. fainting WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29 WEB: http://en.wikipedia.org/wiki/Unconsciousness 10024855 10042772 syncope AE CTCAE: E12832 HPO: HP_0001279 NCIt: C35053 SIDER: C0039070 a skin adverse event that has an outcome of sweating According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH sweating AE HPO: HP_0000975 SIDER: C0038990 According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH, SS WEB: http://en.wikipedia.org/wiki/Abdominal_pain 10000081 a pain AE that is observed in abdominal cavity abdominal pain AE HPO: HP_0002027 SIDER: C0000737 an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states YH, SS, MW blood pressure increased WEB: http://www.ncbi.nlm.nih.gov/pubmed/21722707 10005750 10020772 hypertension AE CTCAE: E13785 HPO: HP_0000822 MP: MP_0000231 NCIt: C3117 SIDER: C0020538 a cardiac valve disease AE that is characterized by a condition of the heart in which the aortic valve, located between the aorta and left ventricle of the heart, is norrower than normal size SS WEB: http://medical-dictionary.thefreedictionary.com/aortic+valve+stenosis 10002918 aortic valve stenosis AE HPO: HP_0005173 SIDER: C0003507 a muscular weakness AE that has an outcome of myasthenia. Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. YH, SS myasthenia gravis myasthenia syndrome AE myasthenic syndrome AE myasthenia AE HPO: HP_0001324 SIDER: C0947912 a pain AE that occurs at the chest According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). YH 10008479 chest pain AE HPO: HP_0001681 SIDER: C0008031 a sensory neuropathy AE which has an outcome of sensory axonal characterized by damage to axonas of the peripheral nervous system (PNS) AG, YH sensory axonal AE an abnormal vision AE characterised by leakage of fluid under the retina causing visual impairment, usually in one eye. SJ, YH central serous chorioretinopathy WEB: http://en.wikipedia.org/wiki/Central_serous_retinopathy 10063118 central serous retinopathy AE a movement disorder AE that has an outcome of twitching, an involuntary sudden movement of part of the body. According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). YH twitching AE a seizure AE that has an outcome of a seizure disorder associated with an elevated temperature YH, BY http://emedicine.medscape.com/article/1176205-overview febrile seizure AE a respiratory system AE which has an outcome of asthma YH 哮喘 10003553 Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation. asthma AE HPO: HP_0002099 SIDER: C0004096 a pain AE that has an outcome of neck pain According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10028836 neck pain AE CTCAE: E12493 HPO: HP_0003418 NCIt: C50663 SIDER: C0007859 an arthritis AE that has an outcome of inflammation of a joint, resulting from infectious agents, such as bacteria and viruses DJ, SS, YH WEB: http://www.rightdiagnosis.com/i/infectious_arthritis/intro.htm 10060968 arthritis infective AE HPO: HP_0003095 SIDER: C0003869 a pain AE that has an outcome of back pain According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10003988 back pain AE CTCAE:E12388 HPO: HP_0003418 NCIt:C41830 SIDER: C0004604 a hair AE that has an outcome of alopecia and occurs after a medical intervention. VAE, MW 10001760 alopecia means the absence of hair or loss of hair. It is not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition. alopecia AE CTCAE:E13611 HPO: HP_0001596 MP: MP_0000414 NCIt:C50575 SIDER: C0002170 a hemorrhage AE that has an outcome of gastrointestinal hemorrhage gastrointestinal haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/gastrointestinal+hemorrhage 10017955 bleeding in the stomach and/or the intestines gastrointestinal hemorrhage AE MP: MP_0000465 a movement disorder AE that has an outcome of eyes gaze upward According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH eyes gaze upward AE a nervous system AE that shows a damage to or disease affecting the nerves. Neuropathy is often classified according to the types or location of nerves that are affected. Neuropathy can also be classified according to the disease causing it. (For example, neuropathy from the effects of diabetes is called diabetic neuropathy. Ref: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy. YH, RR WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy WEB: http://www.medicalnewstoday.com/articles/147963.php WEB: http://www.neuropathy.org/ 神经病变 neuropathy AE HPO: HP_0007141 SIDER: C0442874 a skin adverse event that has an outcome of skin nodule According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). YH skin nodule AE HPO: HP_0200036 SIDER: C0037287 a movement disorder AE that has an outcome of arthrosis. YH Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage. arthrosis AE a muscle adverse event which has an outcome of hypokinesia, refering to slow or diminished movement of body musculature. YH 10021021 hypokinesia AE HPO: HP_0002375 SIDER: C0086439 Muscle twitch AE is a twitching AE that is a small, local, involuntary muscle contraction and relaxation which may be visible under the skin. JX, YH WEB: http://en.wikipedia.org/wiki/Fasciculation fasciculation AE muscle contraction AE myokymia AE 10028346 muscle twitch AE skin discoloration AE is a skin adverse event that results in change in color of skin or mucus membranes According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH, SS skin discolouration AE 10040829 skin discoloration AE a varicella zoster virus infection AE that occurs in adults and rarely in children. YH herpes zoster AE zoster AE WEB: http://www.mayoclinic.org/diseases-conditions/shingles/basics/causes/con-20019574 10019974 Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles (an illness with very different symptoms) often many years after the initial infection. shingles AE HPO: HP_0005353 SIDER: C0019360 a movement disorder AE that has an outcome of laryngismus According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH laryngospasm sudden laryngeal spasm with crowing inhalation and cyanosis Laryngismus is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. laryngismus AE a behavior and neurological AE that has an outcome of disorder in speech YH 10041466 speech disorder AE HPO: HP_0006977 SIDER: C0037822 a cardiovascular disorder AE that has an outcome of hemorrhage bleeding AE haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage 10055798 loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels hemorrhage AE MP: MP_0001914 a bone disorder AE which has an outcome of neck rigidity YH neck rigidity AE a nervous system AE that has the symptom of GBS. Guillain-Barre syndrome (GBS) is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barre occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm. YH, SS GBS AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299621 10018767 Guillain-Barre syndrome AE HPO: HP_0007131 SIDER: C0018378 an abnormal digestion AE which has an outcome of nausea and vomiting According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). This term will most likely removed since it is just a combination of nausea and vomiting. YH nausea and vomiting AE a sudden death AE that occurs to an infant. According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). YH sudden infant death AE a fever AE that has an outcome of fever with chills, which is successive stages of chills and fever. This is a symptom of malaria. YH chills and fever AE 10016559 fever with chills AE a psychiatric disorder AE that is characterized by enduring maladaptive patterns of behavior, cognition, and inner experience, exhibited across many contexts and deviating markedly from those accepted by the individual's culture. YH, MW WEB: https://en.wikipedia.org/wiki/Personality_disorder 10034721 personality disorder AE HPO: HP_0000751 SIDER: C0031212 a respiratory system AE which has an outcome of lung disorder YH lung disorder AE 10025082 lung AE HPO: HP_0006552 SIDER: C0024115 a musculoskeletal system AE that occurs in muscle. YH muscle AE an adverse event that occurs in liver, biliary, and pancreatic areas. YH, JX liver, biliary, and pancreatic disorder AE URL: http://www.ijhpd.com/ WEB: http://www.uchospitals.edu/online-library/content=P00670 hepatobiliary or pancreatic AE a liver/biliary system AE which has an outcome of an enlarged liver, or larger than average size of the liver According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly' was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). enlarged liver AE MP: MP_0000599 a brain inflammation AE which results in an inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases. YH, JX WEB: http://www.cdc.gov/meningitis/index.html 脑膜炎 10027199 meningitis AE CTCAE: E11458 HPO: HP_0001287 NCIt: C26828 SIDER: C0025289 an AE that occurs in digestive system. YH digestive system AE a paralysis AE that has an outcome of paralysis in face According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). YH facial paralysis AE HPO: HP_0007209 SIDER: C0015469 a psychiatric disorder AE that has an outcome of confusion, which is a mild form of delirium. YH, KM confused state AE mental confusion AE WEB: http://medical-dictionary.thefreedictionary.com/mental+confusion 10010300 10010305 confusion AE CTCAE: E12889 NCIt: C37928 a musculoskeletal system AE which has an outcome of joint disorder YH joint disorder AE an AE that occurs in eye. YH eye disorder AE 10015916 eye AE HPO: HP_0000496 SIDER: C0015397 a behavior and neurological AE that has an outcome of autism YH Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. autism AE a hematopoietic system AE which has an outcome of sedimentation rate increased According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term should be inferred to lab test abnormal. YH ESR erythrocyte sedimentation rate red blood cell sedimentation rate increased AE sedrate Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short. red blood cell sedimentation rate increased AE is an AE: sedimentation rate increased that has an increase in rate at which red blood cells precipitate in a period of 1 hour. sedimentation rate increased AE an arthritis AE that has an outcome of arthritis due to an infection in another part of the body DJ, SS, YH, DA reactive arthritis AE reiter's syndrome AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/16822921 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563769/ https://www.ncbi.nlm.nih.gov/pubmed/18436339 10003267 10038294 arthritis reactive AE an abnormal vision AE which has an outcome of amblyopia YH 10001906 amblyopia AE HPO: HP_0000646 SIDER: C0002418 a psychiatric disorder AE that has an outcome of mental retardation YH mental retardation AE HPO: HP_0001249 SIDER: C0025362 a rash AE which shows red, target-shaped or "bulls-eye" patches or sores on the skin. YH, MW WEB: http://kidshealth.org/parent/infections/skin/erythema_multiforme.html WEB: https://en.wikipedia.org/wiki/Erythema_multiforme 10015218 The erythema multiforme rash usually begins on the arms, hands, legs, and feet, but you might also find it on the face, neck, and body. It also can affect the lips and inside the mouth. It usuallys follows an infection or drug exposure. erythema multiforme AE CTCAE:E13627 HPO: HP_0010783 NCIt:C3024 SIDER: C0014742 a lab test abnormal AE that has an outcome of SGOT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST). SGOT increased AE a lab test abnormal AE that has an outcome of SGPT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT). SGPT increased AE a behavioral and neurological AE that has an outcome of thinking abnormality According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH, JX 10043431 thinking abnormality AE an abnormal digestion AE which has an outcome of dyspepsia According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH 10013946 Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating. dyspepsia AE CTCAE: E10617 HPO: HP_0002577 NCIt: C26756 SIDER: C0013395 an allergy AE which has an outcome of anaphylactoid reaction AE is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22293078 10002198 10002216 anaphylactoid reaction AE HPO: HP_0100845 SIDER: C0340865 a digestive system AE which has an outcome of a gastrointestinal disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH gastrointestinal disorder AE HPO: HP_0011024 SIDER: C0017178 an edema AE that has an outcome of accumulation of fluid in the peritoneal cavity DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23296107 10003445 ascites AE CTCAE: E10502 HPO: HP_0001541 NCIt: C2885 SIDER: C0003962 a hypersensitivity AE which has an outcome of serum sickness According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10040400 Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). serum sickness AE CTCAE: E11276 NCIt: C79718 an abscess AE which has an outcome of injection-site abscess YH injection-site abscess AE a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of a procedure that uses small, flat metal discs (electrodes) attached to your scalp to detect electrical activity in your brain According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, EB WEB: http://www.mayoclinic.com/health/eeg/MY00296 10000130 abnormal electroencephalogram result AE a dizziness AE that has an outcome of vertigo According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH 10047340 Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking. vertigo AE CTCAE: E10291 HPO: HP_0002321 NCIt: C38057 SIDER: C0042571 a cardiac disorder AE that has an outcome of heartarrest, the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole. YH cardiopulmonary arrest circulatory arrest heart arrest AE WEB: http://en.wikipedia.org/wiki/Myocardial_infarction WEB: http://medical-dictionary.thefreedictionary.com/cardiac+arrest 10007515 10007617 10028596 cardiac arrest CTCAE: E10101 NCIT: C50479 a respiratory system inflammation AE which has an outcome of bronchitis YH Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes. bronchitis AE HPO: HP_0002837 SIDER: C0006277 a seizure AE that has an outcome of grand malconvulsion YH A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). grand malconvulsion AE a liver related investigation result abnormal AE which shows an abnormal test result in a liver function test, indicating aberrant function of liver. According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). WEB: http://medical-dictionary.thefreedictionary.com/hepatic+function 10019670 10024690 liver function test abnormal AE MP: MP_0000609 an AE that occurs in ear. YH ear disorder AE ear AE HPO: HP_0000598 SIDER: C0013447 an infection AE that results in detrimental colonization of a host organism by virus YH, SS viral infection WEB: http://en.wikipedia.org/wiki/Viral_infection viral infection AE HPO: HP_0005364 SIDER: C0042769 a movement disorder AE that has an outcome of lacrimation disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH Lacrimation is the production, secretion, and shedding of tears. lacrimation disorder AE a liver/biliary system AE which has an outcome of jaundice, which is the clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). SS, YH icterus AE WEB: http://en.wikipedia.org/wiki/Jaundice 10023126 jaundice AE HPO: HP_0000952 MP: MP_0000611 SIDER: C0022346 an immune system disorder AE which shows an enclosed collection of liquefied tissue, known as pus, somewhere in the body. Abscess is the result of the body's defensive reaction to foreign material. YH abscessus WEB: http://medical-dictionary.thefreedictionary.com/abscess 10000269 An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body. abscess AE HPO: HP_0002722 SIDER: C0000833 a pain AE that has an outcome of eye pain According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH 10015958 eye pain AE CTCAE: E10376 HPO: HP_0200025 NCIt: C78287 SIDER: C0151827 a sensory capability AE that has an outcome of palpitation YH WEB: http://en.wikipedia.org/wiki/Palpitations 10033557 A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency. palpitation AE an edema AE which has an outcome of tongue edema YH, RR tongue oedema AE tongue swelling AE WEB: http://www.medterms.com/script/main/art.asp?articlekey=97582 10042727 tongue edema AE a pain AE that has an outcome of ear pain According to the Vaccine Adverse Event Reporting System (VAERS), 'ear pain' was mentioned in 302 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH 10014020 ear pain AE CTCAE: E10262 HPO: HP_0010833 NCIt: C37944 SIDER: C0013456 an edema AE which has an outcome of angioedema YH, SJ angioneurotic edema WEB: http://www.mayoclinic.org/diseases-conditions/hives-and-angioedema/basics/definition/con-20014815 10002473 Angioedema is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues often around the eyes and lips. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis. angioedema AE An arthritis AE that has the outcome of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body. YH rheumatoid arthritis AE HPO: HP_0005681 SIDER: C0003873 an AE that occurs in immune system. According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH immune system disorder AE immune system AE HPO: HP_0002715 SIDER: C0021053 an immune system disorder AE which has an outcome of antinuclear antibody present According to the Vaccine Adverse Event Reporting System (VAERS), 'antinuclear antibody present'; is an adverse event that was mentioned in 288 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH anti-nuclear factor present The presence of anti-nuclear antibodies (ANAs) that are antibodies directed against contents of the cell nucleus. ANAs are present in higher than normal numbers in autoimmune disease. The ANA test measures the pattern and amount of autoantibody which can attack the body's tissues as if they were foreign material. Autoantibodies are present in low titers in the general population, but in about 5% of the population, their concentration is increased, and about half of this 5% have an autoimmune disease. antinuclear antibody present AE a nervous system AE which involves inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs. YH, MW 10028524 myelitis AE CTCAE: E12732 NCIt: C26832 a headache AE that has an outcome of migraine According to the Vaccine Adverse Event Reporting System (VAERS), 'migraine'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH migraine headache A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit. migraine AE HPO: HP_0002076 SIDER: C0149931 Thrombocytopenic purpura AE are purpura AE associated with a reduction in circulating blood platelets which can result from a variety of causes. According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenic purpura'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH 10043561 thrombocytopenic purpura AE HPO: HP_0004829 SIDER: C0857305 multiple sclerosis AE is an immune system disorder AE, or an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination. YH MS disseminated sclerosis encephalomyelitis disseminata 10028245 multiple sclerosis AE a behavior and neurological AE that has an outcome of amnesia in a patient YH, MW 10001949 Amnesia is a short term memory condition in which memory is disturbed. In simple terms it is the loss of memory. amnesia AE CTCAE:E12585 HPO: HP_0002354 NCIt:C2867 SIDER: C0002622 a movement disorder AE that has an outcome of incoordination According to the Vaccine Adverse Event Reporting System (VAERS), 'incoordination' was mentioned in 261 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH a lack of normal adjustment of muscular action so that the intended movement of the limb or other part is not made smoothly and harmoniously, and does not accurately achieve its objective. If the abnormality is hypermetric, the condition is referred to as ataxia. If it is inclined to weakness, e.g. knuckling at the turn, stumbling, failure to flex limbs properly, or to misdirection as in a proprioceptive deficit, it is called incoordination. incoordination AE a speech disorder that has an outcome of voice alteration YH, MW 10047681 voice alteration AE CTCAE: E13601 NCIt: C61043 a pregnancy AE that is the termination of a pregnancyby the removal or expulsion from the uterus of a fetus or embryo, resulting in or caused by its death. According to the Vaccine Adverse Event Reporting System (VAERS), 'abortion'; is an adverse event that was mentioned in 257 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH, SS WEB: http://en.wikipedia.org/wiki/Abortion 10000210 abortion AE a psychiatric disorder AE that has an outcome of shock YH acute stress disorder AE acute stress reaction AE mental shock AE 10001084 Mental shock (or shock) is a psychological condition arising in response to a terrifying event. It should not be confused with the unrelated circulatory condition of shock. There are two types of shocks. Another is circulatory shock which is physiological with MedDRA ID of 10040560. psychological shock AE a skin discoloration AE which has an outcome of purpura According to the Vaccine Adverse Event Reporting System (VAERS), 'purpura'; is an adverse event that was mentioned in 251 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH, MW 紫癜 10037549 Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia. Reference: http://en.wikipedia.org/wiki/Purpura. purpura AE CTCAE:E13690 HPO: HP_0000979 NCIt:C78787 SIDER: C0034150 an infection AE that results in detrimental colonization of a host organism by bacteria YH, SS bacterial infection AE WEB: http://en.wikipedia.org/wiki/Bacterial_infection 10060945 bacterial infection AE HPO: HP_0002718 SIDER: C0004623 a skin adverse event that has an outcome of skin striae that displays irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions. According to the Vaccine Adverse Event Reporting System (VAERS), 'skin striae'; is an adverse event that was mentioned in 247 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH stretch marks striae distensae skin striae AE HPO: HP_0001065 SIDER: C0152459 a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention. YH acute brain syndrome AE a sensory capability AE that has an outcome of coma YH 10010071 Coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions. coma AE HPO: HP_0001259 SIDER: C0009421 a muscle adverse event which has an outcome of hyperkinesia, an abnormal increase in muscular activity. YH 10020651 hyperkinesia AE HPO: HP_0002487 SIDER: C0424295 an AE that occurs in cardiovascular system. YH cardiovascular disorder AE 10007649 cardiovascular AE HPO: HP_0001626 SIDER: C0007222 a nervous system AE which has an outcome of encephalopathy, which is disorder or disease of the brain. YH, MW 10014625 encephalopathy AE CTCAE:E12652 HPO: HP_0007239 NCIt:C26920 SIDER: C0085584 a urinary system AE that has an outcome of urine abnormality AE YH urine abnormality AE HPO: HP_0011036 SIDER: C0235639 a gastrointestinal disorder AE which has an outcome of gastroenteritis, an inflammation occuring in the gastrointestinal tract that involves both the stomach and the small intestine, often results in diarrhea, vomiting and abdominal pain and cramping According to the Vaccine Adverse Event Reporting System (VAERS), 'gastroenteritis' was mentioned in 218 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH WEB: http://medical-dictionary.thefreedictionary.com/gastroenteritis 10017888 gastroenteritis AE HPO: HP_0004386 SIDER: C0017160 a cardiovascular disorder AE that has an outcome of peripheral vascular disorder YH peripheral vascular disorder AE HPO: HP_0005299 SIDER: C0085096 a urinary tract disoder AE that has an outcome of urnary tract infection AE YH 10046571 urinary tract infection AE CTCAE: E11614 HPO: HP_0000094 NCIt: C50791 SIDER: C0042029 an abnormal salivary gland physiology AE which has an outcome of increased salivation, meaning greater than normal amounts of flowing saliva According to the Vaccine Adverse Event Reporting System (VAERS), 'increased salivation' is an adverse event that was mentioned in 336 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). increased salivation AE MP: MP_0000622 a psychiatric disorder AE that has an outcome of depression. Depression causes a persistent feeling of sadness and loss of interest. YH, MW WEB: http://www.mayoclinic.org/diseases-conditions/depression/basics/definition/con-20032977 10012378 depression AE CTCAE:E12909 HPO: HP_0000716 NCIt:C2982 SIDER: C0011570 a glucose homeostasis AE which has an outcome of diabetes mellitus YH diabetes AE 10012601 Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia). diabetes mellitus AE HPO: HP_0000819 SIDER: C0011849 a respiratory system inflammation AE which has an outcome of laryngitis According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngitis'; is an adverse event that was mentioned in 190 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10023874 Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice because of irritation to the vocal folds (vocal cords). laryngitis AE CTCAE: E11435 HPO: HP_0001600 NCIt: C26811 SIDER: C0023067 a muscle spasm AE which has an outcome of generalized spasm, which is an involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH). YH generalized spasm AE According to the Vaccine Adverse Event Reporting System (VAERS), 'reflexes decreased'; is an adverse event that was mentioned in 178 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH hyporeflexia AE Obsoleted because of duplication. It's an alternative term of hyporeflexia AE now. a movement disorder AE that has an outcome of reflexes decreased, an abnormal decrease in an involuntary response to a peripheral stimulus obsolete: reflexes decreased AE a digestive system AE which has an outcome of dry mouth, which is dryness of the mouth resulting from reduced salivary secretion According to the Vaccine Adverse Event Reporting System (VAERS), 'dry mouth'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH xerostomia 10013781 dry mouth AE CTCAE: E10578 HPO: HP_0000217 NCIt: C26917 SIDER: C0043352 a neuritis AE which has an outcome of optic neuritis YH 10030942 optic neuritis AE HPO: HP_0100653 SIDER: C0029134 a cardiovascular disorder AE that has an outcome of thrombocythemia YH Thrombocythemia (primary thrombocythemia) is a disorder in which excess platelets are produced, leading to abnormal blood clotting or bleeding. thrombocythemia AE - OBSOLETE (due to duplication) a hemorrhage AE that has an outcome of epistaxis YH, MW nosebleed 10015090 Epistaxis is the relatively common occurrence of hemorrhage from the nose, usually noticed when the blood drains out through the nostrils. epistaxis AE CTCAE:E13374 HPO: HP_0000421 NCIt:C26766 SIDER: C0014591 a syndrome AE that displays a lupus syndrome. Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. This results in symptoms such as inflammation, swelling, and damage to joints, skin, kidneys, blood, the heart, and lungs. YH, JX lupus syndrome AE 狼疮样综合征 WEB: http://www.medicalnewstoday.com/info/lupus/ lupus AE an eye disorder AE which has an outcome of photophobia YH 10034960 Photophobia is a symptom of excessive sensitivity to light and the aversion to sunlight or well-lit places. In medical terms it is not fear, but an experience of discomfort or pain to the eyes due to light exposure. photophobia AE CTCAE: E10416 HPO: HP_0000613 NCIt: C28210 SIDER: C0085636 a digestive system AE which has an outcome of abnormal salivary gland physiology, which is any functional anomaly of any of the glands in the mouth that secrete saliva abnormal salivary gland physiology AE MP: MP_0005310 a psychiatric disorder AE that has an outcome of hallucination YH, MW hallucinations AE 10019063 10019077 A hallucination, in the broadest sense, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space. hallucination AE CTCAE: E12919 HPO: HP_0000738 NCIt: C37961 SIDER: C0018524 a digestive system AE which has an outcome of tongue disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue disorder'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH tongue disorder HPO: HP_0000157 SIDER: C0040409 a pain AE that has an outcome of neuralgia According to the Vaccine Adverse Event Reporting System (VAERS), 'neuralgia'; is an adverse event that was mentioned in 155 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10029223 Neuralgia or neuropathic pain can be defined most simply as non-nociceptive pain. Neuralgia is pain produced by a change in neurological structure or function. Unlike nociceptive pain, Neuralgia exists with no continuous nociceptive input. Neuralgia falls into two categories: central Neuralgia and peripheral Neuralgia. neuralgia AE CTCAE:E12744 HPO: HP_0003489 NCIt:C79695 SIDER: C0027796 an edema AE which has an outcome of lung edema YH lung edema AE a paresthesia AE that occurs around the mouth. YH circumoral paresthesia AE HPO: HP_0003401 SIDER: C0151838 an abnormal fluid regulation AE which has an outcome of thirst YH 10043458 Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance. thirst AE HPO: HP_0001959 SIDER: C0039971 a musculoskeletal system AE that occurs in the bone YH bone disorder 10005956 bone AE HPO: HP_0000924 SIDER: C0005940 a perinatal AE that displays fetal disorder. YH fetal disorder AE a sensory capability AE that has an outcome of emotional liability YH emotional liability AE a muscle adverse event which has an outcome of muscle spasm, which is an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions SS, YH WEB: http://en.wikipedia.org/wiki/Spasm 10028334 muscle spasm AE MP: MP_0000743 a connective tissue disorder AE that occurs at the location of tendon A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension. According to the Vaccine Adverse Event Reporting System (VAERS), 'tendon disorder'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH Tendon disorder is a medical condition that results in a tendon not functioning normally. tendon disorder AE a behavior and neurological AE that has an outcome of hostility YH 10020400 hostility AE an eye disorder AE which has an outcome of visual field defect SS, YH visual impairment AE WEB: http://en.wikipedia.org/wiki/Visual_impairment 10047555 10047571 visual field defect AE a muscle adverse event which has an outcome of myopathy AE, an abnormal condition or disease of the skeletal muscle 10028641 myopathy AE HPO: HP_0003198 MP: MP_0000751 SIDER: C0026848 a behavior and neurological AE that has an outcome of apathy state YH impassivity perfunctoriness 10002942 Apathy is a state of indifference, or the suppression of emotions such as concern, excitement, motivation and passion. An apathetic individual has an absence of interest or concern to emotional, social, or physical life. They may also exhibit an insensibility or sluggishness. apathy AE HPO: HP_0000741 SIDER: C0085632 a paralysis AE that has an outcome of hemiplegia According to the Vaccine Adverse Event Reporting System (VAERS), 'hemiplegia'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10019468 Hemiplegia is total paralysis of the arm, leg, and trunk on the same side of the body. Hemiplegia is more severe than hemiparesis, wherein one half of the body is weakened but not paralysed. hemiplegia AE HPO: HP_0002301 SIDER: C0018991 a rash AE that is characterized by a circumscribed and elevated skin lesion filled with pus. According to the Vaccine Adverse Event Reporting System (VAERS), 'pustular rash'; is an adverse event that was mentioned in 128 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH rash pustular AE 10037888 pustular rash AE CTCAE: E11545 NCIt: C80119 a blood creatine phosphokinase level abnormal AE that is characterized by an increased level of creatine phosphokinase (CPK) or phosphocreatine kinase, an enzyme expressed by various tissue types that catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP) YH, EB elevated serum creatine phosphate kinase AE 10005470 blood creatine phosphokinase level increased AE a hypertension AE that has an outcome of elevated pressure in the skull. YH, SS WEB: http://www.ihrfoundation.org/intracranial/hypertension/info/C16 10049977 intracranial hypertension AE a sensory neuropathy AE which shows a painful neuropathy characterized by damage to sensory and motor nerves AG, YH sensorimotor painful neuropathy AE a digestive system AE which has an outcome of abnormal stool According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal stools' was mentioned in 111 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH abnormal stool AE a pain AE that has an outcome of bone pain According to the Vaccine Adverse Event Reporting System (VAERS), 'bone pain' was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10006002 bone pain AE CTCAE:E12392 HPO: HP_0002653 NCIt:C38644 SIDER: C0151825 a cardiovascular disorder AE that comes with cerebrovascular accident YH stroke 10008190 Cerebrovascular accident: The sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A CVA is also referred to as a stroke. cerebrovascular accident AE HPO: HP_0001297 SIDER: C0038454 a digestive system AE which has an outcome of parotid gland enlargement According to the Vaccine Adverse Event Reporting System (VAERS), 'parotid gland enlargement' was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10034023 parotid gland enlargement AE a movement disorder AE that has an outcome of flatulence According to the Vaccine Adverse Event Reporting System (VAERS), 'flatulence' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10016766 Flatulence is the production of a mixture of gases in the digestive tract of mammals or other animals that are byproducts of the digestion process. Such a mixture of gases is known as flatus, and is expelled from the rectum in a process colloquially referred to as "passing gas" or "farting". flatulence AE CTCAE: E10697 HPO: HP_0011024 NCIt: C37954 SIDER: C0016204 a liver/biliary system AE which has an outcome of liver damage According to the Vaccine Adverse Event Reporting System (VAERS), 'liver damage' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH liver damage AE a respiratory system AE which has an outcome of sore throat YH, MW 10041367 sore throat AE CTCAE: E13575 NCIt: C50747 a movement disorder AE that results in the loss of power of voluntary movement in a muscle through injury or disease of its nerve supply According to the Vaccine Adverse Event Reporting System (VAERS), 'paralysis' is an adverse event that was mentioned in 574 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). SS, YH WEB: https://www.nlm.nih.gov/medlineplus/paralysis.html 瘫痪 10033799 paralysis AE HPO: HP_0010549 MP: MP_0000753 SIDER: C0522224 a bone disorder AE that has an outcome of cellular death of bone components due to interupption of blood supply DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/avascular+necrosis 10003460 aseptic necrosis bone AE a physical examination result abnormal AE that has an outcome of weight loss, which is the progressive reduction of body weight below normal average for age MW, YH weight decreased AE 10047895 10047900 weight loss AE CTCAE: E12228 MP: MP_0001263 NCIt: C3445 According to the Vaccine Adverse Event Reporting System (VAERS), 'ataxia' is an adverse event that was mentioned in 555 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10003591 a movement disorder AE that has an outcome of ataxia, inability to coordinate voluntary muscular movements ataxia AE CTCAE:E12597 HPO: HP_0001251 MP: MP_0001393 NCIt:C26702 SIDER: C0004134 a hair, skin, and nail AE that occurs in skin. YH WEB: http://www.thefreedictionary.com/skin+disorder 10040831 skin AE a movement disorder AE that has an outcome of unusual or distinctive way of walking According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal gait' is an adverse event that was mentioned in 998 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). SS, YH gait disturbance AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/21224774 10017577 abnormal gait AE CTCAE: E11112 MP: MP_0001406 NCIt: C78303 an abnormal fluid regulation AE which has an outcome of dehydration, which is an excessive water loss from the body or from an organ or bodily part YH, SS, MW hypohydration 10012174 dehydration AE CTCAE:E12258 HPO: HP_0001944 MP: MP_0001429 NCIt:C26740 SIDER: C0011175 a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid abnormal fluid regulation AE MP: MP_0001784 a glucose homeostasis AE which has an outcome of hyperglycemia, which is an abnormally high concentration of glucose in the blood; generally refers to a pathological state YH, MW WEB: http://medical-dictionary.thefreedictionary.com/hyperglycemia 10020635 10020639 hyperglycemia AE CTCAE: E12276 MP: MP_0001559 NCIt: C26797 a homeostasis AE which has an outcome of abnormal ciculating bilirubin level, which is aberrant concentration in the blood of this yellow heme breakdown product According to the Vaccine Adverse Event Reporting System (VAERS), 'bilirubinemia'; is an adverse event that was mentioned in 221 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). abnormal circulating bilirubin level AE MP: MP_0001569 a skin adverse event that has an outcome of cyanosis, a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood According to the Vaccine Adverse Event Reporting System (VAERS), 'cyanosis' is an adverse event that was mentioned in 1,804 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). 10011703 cyanosis AE HPO: HP_0000961 MP: MP_0001575 SIDER: C0010520 a hematopoietic system AE which has an outcome of anemia, which is less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs anaemia AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001586/ 10002034 10002272 anemia AE CTCAE: E10010 MP: MP_0001577 NCIt: C2869 an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states YH, MW blood pressure decreased, low blood pressure 10005734 10021097 hypotension AE CTCAE: E13791 HPO: HP_0002615 MP: MP_0001596 NCIt: C3128 SIDER: C0020649 an arrhythmia AE that has an outcome of uneven timing of heart contraction irregular heartbeat AE MP: MP_0001636 an electrolyte lab test abnormal AE that shows an abnormal level of an electrolyte in the blood YH, MW electrolyte blood test abnormal AE a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy abnormal digestion AE MP: MP_0001664 an AE that occurs in the homeostasis system. anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues homeostasis AE MP: MP_0001764 an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues oedema, swelling, dropsy WEB: http://en.wikipedia.org/wiki/Oedema WEB: http://en.wikipedia.org/wiki/Swelling_(medical) 10016807 10030095 10042674 edema AE MP: MP_0001785 an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult. SS, YH WEB: http://en.wikipedia.org/wiki/Inflammation 10061218 inflammation AE HPO: HP_0007891 MP: MP_0001846 SIDER: C0021368 an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). brain inflammation AE MP: MP_0001847 an ear disorder AE which has an outcome of increased susceptibility to otitis media, which is greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection increased susceptibility to otitis media AE MP: MP_0001850 an eye disorder AE which has an outcome of eye inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the eye 10015943 eye inflammation AE HPO: HP_0100533 MP: MP_0001851 SIDER: C0239429 an eye inflammation AE which has an outcome of conjunctivitis, which is inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball 10010741 conjunctivitis AE CTCAE: E10355 HPO: HP_0000509 MP: MP_0001852 NCIt: C34504 SIDER: C0009763 an inflammation AE that shows a local accumulation of fluid, plasma proteins, and leukocytes in the liver According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatitis' was mentioned in 387 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, JX liver inflammation AE MP: MP_0001860 aa inflammation AE which has an outcome of lung inflammation, a local accumulation of fluid, plasma proteins, and leukocytes in the lung According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). lung inflammation AE MP: MP_0001861 an inflammation AE which occurs in the respiratory system, which is reflected with the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system respiratory system inflammation AE MP: MP_0002405 an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel It's an inflammation. YH, MW 10047115 vasculitis AE CTCAE:E13837 HPO: HP_0002633 MP: MP_0001864 NCIt:C26912 SIDER: C0042384 an inflammation AE which has an outcome of salivary gland inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland salivary gland inflammation AE MP: MP_0001870 a respiratory system inflammation AE which has an outcome of sinus inflammation, an inflammation of paranasal sinuses, which may be due to infection, allergy, or autoimmune issues. According to the Vaccine Adverse Event Reporting System (VAERS), 'sinusitis'; is an adverse event that was mentioned in 298 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). SS, YH, RR sinus inflammation AE WEB: http://en.wikipedia.org/wiki/Sinusitis 10040753 sinusitis AE CTCAE: E11563 HPO: HP_0000246 MP: MP_0001872 NCIt: C35024 SIDER: C0037199 a hypersensitivity AE which results in an allergic response showing a marked increase in reactivity to an antigen upon subsequent exposure. JX, LW, YH allergic reaction AE allergic response AE anaphylactic reaction AE WEB: http://en.wikipedia.org/wiki/Allergy 变态反应 过敏反应 10001718 10001738 allergy AE CTCAE: E11248 MP: MP_0001878 NCIt: C3114 a nervous system AE which has an outcome of abnormal cerebrospinal fluid production, an anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord abnormal cerebrospinal fluid production AE MP: MP_0001911 an AE that occurs in nervous system. KY, YH nervous system disorder AE URL: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/overview_of_nervous_system_disorders_85,P00799/ 10029202 nervous system AE MP: MP_0003633 a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He abnormal respiration AE MP: MP_0001943 an abnormal respiration AE which has an outcome of apnea, temporary cessation of breathing; sometimes episodic According to the Vaccine Adverse Event Reporting System (VAERS), 'apnea' is an adverse event that was mentioned in 1,618 VAERS reports (1.3%) during1991-2001 (Reference: PMID: 12825543). JX, YH, MW MedDRA: 10002974 is for "apnoea"; MedDRA: 10002972 is for "apnea". apnoea AE respiratory arrest AE WEB: http://medical-dictionary.thefreedictionary.com/apnea apnea AE CTCAE: E13306 MP: MP_0001957 NCIt: C26698 UMLS CUI: C0003578 an ear disorder AE which has an outcome of deafness, which is an inability to hear 10011878 deafness AE HPO: HP_0000365 MP: MP_0001967 SIDER: C0011053 an adverse event that occurs in a gustatory system YH, JX gustatory system AE MP: MP_0001985 a gustatory system AE which has an outcome of taste sensitivity, or changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system taste sensitivity AE MP: MP_0001986 a urinary system AE that has an outcome of excessive or abnormally large production or passage of urine. LW, ML, JX, YH WEB: http://en.wikipedia.org/wiki/Polyuria 多尿 10036142 polyuria AE an abnormal vision AE which has an outcome of blindness, which is loss of the sense of sight 10005169 blindness AE HPO: HP_0000618 MP: MP_0002001 SIDER: C0456909 an eye disorder AE which has an outcome of abnormal vision, which is an inability or decreased ability to see abnormal vision AE MP: MP_0002090 a behavior and neurological AE that shows a sudden surge of electrical activity in the brain. YH, JX, YH WEB: http://www.healthline.com/symptom/seizures 突然发作 10039906 10039910 seizure AE CTCAE: E12804 MP: MP_0002064 NCIt: C2962 an adverse event that has an outcome of an abnormal behavior and neurological phenotype. YH, JX behavior AE behavioral AE behavioral disorder AE disruptive behavioral disorder AE WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/ any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls behavioral and neurological AE MP: MP_0004924 a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements 10028035 movement disorder AE HPO: HP_0100022 MP: MP_0002066 SIDER: C0026650 a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus sensory capability AE MP: MP_0002067 a homeostasis AE which has an outcome of glucose homeostasis, which is an anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues glucose homeostasis AE MP: MP_0002078 Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal. JX, LW, YH hypersensitivity reaction AE WEB: http://en.wikipedia.org/wiki/Hypersensitivity 超敏反应 10020751 hypersensitivity AE HPO: HP_0100326 MP: MP_0002148 SIDER: C0020517 YH Muscle atrophy is a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation. a muscle adverse event AE which has an outcome of muscular atrophy. muscular atrophy AE MP: MP_0002269 an abnormal respiration AE which has an outcome of hyperventilation, i.e., increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal According to the Vaccine Adverse Event Reporting System (VAERS), 'Petechiae' was mentioned in 510 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). 10020910 hyperventilation AE HPO: HP_0002883 MP: MP_0002320 SIDER: C0020578 an abnormal respiration AE which has an outcome of hypoventilation, i.e., reduced alveolar ventilation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoventilation' is an adverse event that was mentioned in 321 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). QL, YH respiratory depression AE WEB: https://en.wikipedia.org/wiki/Hypoventilation 呼吸抑制 10021133 10038678 hypoventilation AE HPO: HP_0007110 MP: MP_0002321 SIDER: C0398353 an adverse event which occurs in a hematopoietic system, which is any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells hematopoietic system AE MP: MP_0002396 an eye disorder AE which has an outcome of mydriasis, which is dilation of one or both pupils regardless of light conditions 10028521 mydriasis AE HPO: HP_0011499 MP: MP_0002546 SIDER: C0026961 an arrhythmia AE that has an outcome of greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute tachycardia WEB: http://en.wikipedia.org/wiki/Tachycardia 10019303 increased heart rate AE MP: MP_0002626 a behavior and neurological AE that has an outcome of exaggerated reflex action hyperresponsive to tactile stimuli AE MP: MP_0002738 a muscle spasm AE that has an outcome of opisthotonus YH 10030899 opisthotonus is a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward opisthotonus AE HPO: HP_0002179 MP: MP_0002880 SIDER: C0151818 An joint disorder AE that has an outcome of joint inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the joints YH joint inflammation AE MP: MP_0002933 an abnormal enzyme level AE which has an outcome of incraesed lactate dehydrogenase level, which is greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate increased lactate dehydrogenase level AE MP: MP_0002944 an abnormal enzyme level AE which has an outcome of increased circulating alkaline phophatase level, which is an elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood increased circulating alkaline phosphatase level AE MP: MP_0002968 A joint inflammation AE that has an outcome of arthritis, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures YH, MW 关节炎 10003246 arthritis AE CTCAE:E12378 HPO: HP_0001369 MP: MP_0002993 NCIt:C2883 SIDER: C0003864 a digestive system AE which has an outcome of dysphagia, which is a behavior and neurological AE that has an outcome of difficulty in swallowing food or liquid 10013950 dysphagia AE CTCAE: E10621 HPO: HP_0002015 MP: MP_0003158 NCIt: C2980 SIDER: C0011168 an ear disorder AE which has an outcome of decreased lateral semicircular canal size, which is small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance decreased lateral semicircular canal size AE MP: MP_0003162 a hematopoietic system AE which has an outcome of decreased platelet count, which is fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation SS, YH decreased platelet cell number AE 10035528 platelet count decreased AE CTCAE: E12207 HPO: HP_0001873 MP: MP_0003179 NCIt: C3408 SIDER: C0392386 an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit 10028813 nausea AE CTCAE: E10878 HPO: HP_0002018 MP: MP_0003259; MDR: 10028813 NCIt: C3258 SIDER: C0027497 regurgitation AE 10047700 an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity vomiting AE CTCAE: E11068 HPO: HP_0002013 MP: MP_0003260; MDR: 10047700 NCIt: C3442 SIDER: C0042963 an abnormal defecation AE that has an outcome of constipation, which is incomplete, infrequent or difficult evacuation of fecal matter According to the Vaccine Adverse Event Reporting System (VAERS), 'constipation'; is an adverse event that was mentioned in 242 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). infrequent bowel movements AE 10010774 constipation AE CTCAE: E10562 HPO: HP_0002019 MP: MP_0003267 NCIt: C37930 SIDER: C0009806 a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces abnormal defecation AE MP: MP_0003866 a urinary system AE that has an outcome of the symptom of urinary incontinence, which is the inability to control the urinary excretory functions. YH, MW MedDRA: 10046543 WEB: http://www.nlm.nih.gov/medlineplus/urinaryincontinence.html urinary incontinence AE CTCAE: E13042 HPO: HP_0000020 MP: MP_0003280 NCIt: C78497 SIDER: C0042024 clonus AE is a series of involuntary, rhythmic, muscular contractions and relaxations. SJ, YH WEB: http://en.wikipedia.org/wiki/Clonus 10009346 clonus AE causes large motions that are usually initiated by a reflex. clonus AE a skin discoloration AE which has an outcome of pallor, an unnatural paleness to the skin, generally attributable to anemia 10033546 pallor AE HPO: HP_0008361 MP: MP_0003717 SIDER: C0030232 an hearing disorder AE that shows a persistent sensation of buzzing, ringing, clicking, or other noises in the ear 10043882 tinnitus AE CTCAE: E10287 HPO: HP_0000360 MP: MP_0003741 NCIt: C50772 SIDER: C0040264 a digestive system AE which has an outcome of stomatitis, which is an inflammation of the mucous lining of the mouth This is a type of inflammation. WEB: http://medical-dictionary.thefreedictionary.com/stomatitis 10042128 stomatitis AE HPO: HP_0010280 MP: MP_0003746 SIDER: C0038362 a digestive system AE which has an outcome of mouth mucosal ulceration, which is lesions through the mucous membrane of the mouth, usually associated with loss of tissue According to the Vaccine Adverse Event Reporting System (VAERS), 'mouth ulceration' was mentioned in 246 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). mouth mucosal ulceration AE MP: MP_0003747 a muscle adverse event AE that has an outcome of abnormal muscle tone, which is an anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation YH abnormal muscle tone AE MP: MP_0004142 an abnormal muscle tone AE which has an outcome of hypertonia, which is increased muscle tension resulting in stiffness of the muscles in the resting state YH 10020852 hypertonia AE HPO: HP_0001276 MP: MP_0004143 SIDER: C0026826 an abnormal muscle tone AE which has an outcome of hypotonia, which is decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness YH 10021118 hypotonia AE HPO: HP_0009062 MP: MP_0004144 SIDER: C0026827 a muscle inflammation AE which has an outcome of myositis, which is an inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle YH, MW 10028653 myositis AE CTCAE:E12489 HPO: HP_0009071 MP: MP_0004510 NCIt:C27578 SIDER: C0027121 a muscle adverse event which has an outcome of muscle inflammation, which is a local accumulation of fluid, plasma proteins, and leukocytes in muscle YH muscle inflammation AE MP: MP_0004511 a lymphocyte count abnormal AE that has an outcome of greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells According to the Vaccine Adverse Event Reporting System (VAERS), 'lymphocytosis'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). EB increased lymphocyte cell number AE lymphocyte cell number increased AE 10025258 lymphocyte count increased AE CTCAE: E12195 MP: MP_0005013 NCIt: C34791 an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel diarrhoea AE WEB: http://medical-dictionary.thefreedictionary.com/diarrhea 10012735 diarrhea AE CTCAE: E10572 MP: MP_0005036 NCIt: C2987 a homeostasis AE which has an outcome of hypoxia, which is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases YH, MW WEB: http://medical-dictionary.thefreedictionary.com/hypoxia 10021143 hypoxia AE CTCAE:E13388 HPO: HP_0002795 MP: MP_0005039 NCIt:C3890 SIDER: C0242184 an infectious adverse event which has an outcome of the presence of various pathogenic organisms, or their toxins, in the blood or tissues that results in the infections in blood stream. According to the Vaccine Adverse Event Reporting System (VAERS), 'sepsis' was mentioned in 416 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). SS 10040047 sepsis AE CTCAE: E11560 HPO: HP_0002718 MP: MP_0005044 NCIt: C3364 SIDER: C0243026 a urinary system AE that results in the presence of blood in the urine YH, SJ, MW UMLS CUI: C0018965 (hematuria AND haematuria); UMLS CUI: C0947999 (blood urine presence) blood urine blood urine presence haematuria AE WEB: http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/ 10018867 10018870 10019450 hematuria Hematuria AE can be caused by menstruation, vigorous exercise, sexual activity, viral illness, trauma, or infection, such as a urinary tract infection (UTI), along with more serious disorders such as cancer, disease, and clotting. hematuria AE CTCAE: E13000 MP: MP_0005161 NCIt: C3090 a homeostasis AE which has an outcome of abnormal enzyme level, which is an altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances abnormal enzyme level AE MP: MP_0005319 an arrhythmia AE that has an outcome of fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute YH, JX heart rate decreased AE 10019301 decreased heart rate AE MP: MP_0005333 an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine YH urinary system AE MP: MP_0005502 an abnormal body temperature AE which has an outcome of decreased body temperature, which is less than the level of heat natural to a living being YH, SJ decreased body temperature AE 10021113 Hypothermia AE is a medical emergency that occurs when your body loses heat faster than it can produce heat, causing a dangerously low body temperature. hypothermia AE CTCAE: E11122 MP: MP_0005534 NCIt: C78351 a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being abnormal body temperature AE MP: MP_0005535 a peripheral neuropathy AE which has an outcome of neuritis, the local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord 10029240 neuritis AE MP: MP_0006082 diplopia AE 10013036 an abnormal vision AE which has an outcome of double vision, which is two images perceived when only a single object is present double vision AE MP: MP_0006150 an anemia AE which has an outcome of hypochromic anemia, which is a hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs hypochromic anemia AE MP: MP_0008387 an adverse event that is indicated by an abnormal result of an investigation that uses some laboratory equipment, device, or medical technology. This term is used to replace 'lab test abnormal AE'. The reason for this is that some test, like X-ray test, is not considered by many physicians as a lab test. Therefore, we have used this new term to cover a broader scope. All terms asserted under this term represent the investigation results without defined conclusion of disease. EB, SS, YH laboratory test abnormal 10061253 investigation result abnormal AE a movement disorder AE that has an outcome of nervous According to the Vaccine Adverse Event Reporting System (VAERS), 'nervousness' is an adverse event that was mentioned in 583 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). increased, skittish, behavior induced by stimulation such as handling, touching or noise nervous AE MP: MP_0008912 a hemorrhage AE that has an outcome of ecchymosis 10014080 an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis ecchymosis AE HPO: HP_0000978 MP: MP_0009276 SIDER: C0013491 serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death. YH, MC serious adverse event severe adverse event WEB: http://en.wikipedia.org/wiki/Serious_adverse_event WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA serious adverse event a serious adverse event that has an outcome of death. YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm 10011906 10011914 death death AE CTCAE: E11080 HPO: HP_0001645 NCIt: C28554 SIDER: C1306577 a serious AE that is suspected to put the patient at substantial risk of dying at the time of the adverse event, or that the use or continued use of the device or other medical product might have resulted in the death of the patient. DJ, SS, YH, JX apparent life threatening event AE WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm 10065044 life-threating AE a serious adverse event that leads to hospitalization. Such an adverse event resulted in an admission to the hospital or prolongation of hospitalization. YH, JX adverse event leading to hospitalization WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm hospitalization AE a serious adverse event that leads to disability or permanent damage. Such an adverse event results in a substantial disruption of a person's ability to conduct normal life functions, i.e., the adverse event resulted in a significant, persistent or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities and/or quality of life. YH, JX adverse event leading to disability WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm disability or permanent damage AE a serious adverse event that resulted in congenital anomaly and bith defect, leading to suspicions that an exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child. YH, JX adverse event leading to congenital anomaly WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.thefreedictionary.com/birth+defect 10010356 congenital anomaly or birth defect AE a serious adverse event which is an adverse event that requires intervention to prevent permanent impairment or damage leads to suspicions that the use of a medical product may result in a condition which requires a medical or surgical intervention to preclude permanent impairment or damage to a patient. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm adverse event that requires intervention to prevent permanent impairment or damage an adverse event that is considered not serious. YH, MC WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA non-serious adverse event low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C). YH WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 The low-grade level of fever is beneficial. With most microbes/"bugs" that a child will be exposed to, this fever will assist the body in repelling the invader. low-grade fever AE moderate-grade fever AE is a fever adverse event with a temperature typically between 102.2° F and 104.5° F (39° C and 40° C). YH WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 This moderate-grade fever temperature is still considered beneficial. If a child's body has reached this temperature, it's what's needed to kill whatever bacteria or virus their body is attempting to fight. moderate-grade fever AE high-grade fever AE is a fever adverse event with a fever temperature greater than 104.5° F (40° C). YH WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 This fever may cause the child some discomfort and result in crankiness. Generally indicative of a bacterial infection, this fever means that the body is fighting something more serious than the common cold. high-grade fever AE hyperpyrexia AE is a fever adverse event that has an outcome of an excessive and unusual elevation of set body temperature greater than or equal to 41 °C. It is an extremely high fever. Such a high temperature is considered a medical emergency as it may indicate a serious underlying condition such as sepsis. YH extreme pyrexia AE Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. WEB: http://en.wikipedia.org/wiki/Hyperpyrexia 10020741 hyperpyrexia AE HPO: HP_0001945 SIDER: C0392676 a pain AE that has an outcome of musculoskeletal pain SS, YH WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain 10028391 Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones. musculoskeletal pain AE HPO: HP_0003326 SIDER: C0026858 injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection SS, YH WEB: http://en.wikipedia.org/wiki/Erythema WEB: http://medical-dictionary.thefreedictionary.com/erythema 10022061 injection-site erythema AE Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin. SS, YH reddish skin WEB: http://en.wikipedia.org/wiki/Erythema 10015150 erythema AE HPO: HP_0010783 MP:0001190 SIDER: C0041834 a headache AE that has an outcome of sinus headache YH, SS WEB: http://american-rhinologic.org/patientinfo.headache.phtml sinus headache is a headache located over the sinuses, (forehead, corners of the eye, and cheek areas). On occasion, the pain will be felt behind the eyes, in the back of the neck, or may extend into the upper teeth. sinus headache AE HPO: HP_0002315 SIDER: C0037195 an inflammation AE that occurs in the lung. It is often characterized as including inflammation of the parenchyma of the lung (that is, the alveoli) and abnormal alveolar filling with fluid (consolidation and exudation). SS, YH WEB: http://en.wikipedia.org/wiki/Pneumonia 10035664 pneumonia AE HPO: HP_0002090 SIDER: C0032285 lobar pneumonia is pneumonia AE that affects a large and continuous area of the lobe of a lung SS, YH WEB: http://en.wikipedia.org/wiki/Lobar_pneumonia 10024738 lobar pneumonia AE HPO: HP_0002090 SIDER: C0032300 axillary pain AE is a pain AE that occurs in the underarm (the area on the human body directly under the join where the arm connects to the shoulder) SS, YH axillary pain AE an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma". SS, YH bruise AE bruising AE ecchymoses AE haematoma AE WEB: http://en.wikipedia.org/wiki/Hematoma 10006504 10018852 10019428 hematoma AE CTCAE: E13775 (hematoma); CTCAE: E11666 (brruising) HPO: HP_0001892 NCIt: C37921 (Bruising); NCIt: C50579 (Hematoma) SIDER: C0018944 reproductive system AE is an AE that occurs in the reproductive system. YH, SS reproductive system AE an immune system disorder AE which has an outcome of antinuclear antibody negative SS, YH antinuclear antibody negative AE a CSF test result abnormal AE that has an outcome of CSF white blood cell count negative SS, YH, EB 10061099 CSF white blood cell count negative AE a microbiology and serology investigation result abnormal AE that has an outcome of positive influenza serology test result SS, YH, EB 10060078 influenza serology positive AE YH a paralysis AE that has an outcome of VIIth nerve paralysis 10050040 VIIth nerve paralysis AE HPO: HP_0006824 SIDER: C0919980 an aspartate aminotransferase level abnormal AE that has an outcome of an increased amount of AST, an enzyme normally present in body tissues especially of the heart and liver DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/aspartate+aminotransferase 10003481 aspartate aminotransferase level increased AE CTCAE: E12087 NCIt: C26947 an incorrect dose administration that accidentally uses overdose SS, YH 10000381 accidental overdose in medical intervention an immune system disorder AE which has an outcome of acute disseminated encephalomyelitis SS, YH WEB: http://en.wikipedia.org/wiki/Acute_disseminated_encephalomyelitis 10000709 Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually occurs following a viral infection but may appear following vaccination, bacterial or parasitic infection, or even appear spontaneously. As it involves autoimmune demyelination, it is similar to multiple sclerosis, and is considered part of the Multiple sclerosis borderline diseases. acute disseminated encephalomyelitis AE an arrhythmia AE that involves the two upper chambers (atria) of the heart SS, YH AF WEB: http://en.wikipedia.org/wiki/Atrial_fibrillation WEB: http://medical-dictionary.thefreedictionary.com/atrial+fibrillation 10003658 Atrial fibrillation (AF or A-fib) is the most common cardiac arrhythmia (abnormal heart rhythm), and involves the two upper chambers (atria) of the heart. Its name comes from the fibrillating (i.e., quivering) of the heart muscles of the atria, instead of a coordinated contraction. atrial fibrillation AE CTCAE: E10081 HPO: HP_0005110 NCIt: C50466 SIDER: C0004238 a cardiac disorder AE which has an outcome of abnormal heart rhythm SS, YH abnormal heartbeat AE cardiac arrhythmia AE WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/arr/ 10003119 arrhythmia AE HPO: HP_0011675 MP: MP_0004085 SIDER: C0003811 a cardiac valve disease AE that is characterized by a condition of the heart in which one of the valve openings has become narrow and restricts the flow of blood from the upper left chamber (left atrium) to the lower left chamber (left ventricle). SS WEB: http://medical-dictionary.thefreedictionary.com/mitral+valve+stenosis 10027733 mitral valve stenosis AE a blood creatinine level abnormal AE that has an outcome of decreased blood creatine SS, YH, EB 10005482 blood creatinine level decreased AE SS, YH, EB 10007223 carbon dioxide decreased AE a carbon dioxide abnormal AE that has an outcome of a decreased level of carbon dioxide in the blood A contraindication that is specifically for vaccination. SS, YH contraindication to vaccination an infection adverse event that has an outcome of croup infection SS, YH WEB: http://www.medicinenet.com/croup/article.htm Croup is an infectious illness of the respiratory system involving the vocal cords (larynx), the windpipe (trachea), and the upper airways of the lungs (bronchial tubes). The majority of a child's symptoms reflect involvement of the larynx. Croup is usually a viral infection and maybe caused by many different viruses, including those responsible for the common cold and influenza. Rarely, croup is caused by a bacterial infection. croup infection AE a respiratory system AE that has an outcome of the drawing of a foreign substance into the respiratory tract during inhalation DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/aspiration 10003504 aspiration AE CTCAE:E13310 HPO: HP_0002835 NCIt:C15631 SIDER: C0700198 a respiratory system AE that has an outcome of the removal of gas or fluid from the pleural cavity of the lungs DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/aspiration 10003522 aspiration pleural cavity AE a skin adverse event which has an outcome of excoriation AE is an injury to a surface of the body caused by trauma, such as scratching, abrasion, or a chemical or thermal burn. SS, YH WEB: http://medical-dictionary.thefreedictionary.com/excoriation 10049796 excoriation AE a pain AE that has an outcome of facial pain SS, YH WEB: http://www.bettermedicine.com/article/facial-pain 10016059 facial pain is a pain in facial area (eyes, eyebrows, forehead, nose, cheeks, mouth, teeth and chin). Facial pain may include injuries to the nerves or bones that coordinate many of your face’s actions. facial pain AE CTCAE: E11094 HPO: HP_0100661 NCIt: C79594 SIDER: C0015468 a hematology investigation result abnormal AE that has an outcome of abnormal full blood count SS, YH, EB 10017412 10064198 full blood count abnormal AE a reflexes decreased AE that has an outcome of hyporeflexia SS, YH WEB: http://en.wikipedia.org/wiki/Hyporeflexia 10021089 Obsoleted because of duplication hyporeflexia is the condition of below normal or absent reflexes. Hyporeflexia is generally associated with a lower motor neuron deficit (at the alpha motor neurons from the spinal cord to muscle). obsolete: hyporeflexia AE HPO: HP_0009072 SIDER: C0151888 a tumor AE that is characterized by cancer in the brain DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/astrocytoma 10003571 astrocytoma AE HPO: HP_0009592 SIDER: C0004114 a medical intervention that uses incorrect dose SS, YH 10064355 incorrect dose administration a lung disorder AE that has an outcome of collapse in part of or all of a lung DJ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001130/ 10003598 atelectasis AE CTCAE:E13316 HPO: HP_0001642 NCIt:C2888 SIDER: C0004144 an influenza serology positive AE that has an outcome of positive result in an influenza virus test SS, YH, EB 10070717 influenza virus test positive AE joint range of motion decreased AE is a mobility decreased AE that results in limited or decreased range of joint motion SS, YH, MW 10048706 joint range of motion decreased AE CTCAE: E12435 NCIt: C78403 a muscle spasm AE which has an outcome of laryngospasm, which is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. The condition typically lasts less than 60 seconds, and causes a partial blocking of breathing in, while breathing out remains easier. It may be triggered when the vocal cords or the area of the trachea below the cords detects the entry of water, mucus, blood, or other substance. It is characterized by stridor and or retractions. SS, YH, MW WEB: http://en.wikipedia.org/wiki/Laryngospasm 10023891 laryngospasm AE CTCAE:E13439 HPO: HP_0006511 NCIt:C79609 SIDER: C0023066 a lymphocyte percentage abnormal AE that has an outcome of decreased lymphocyte percentage SS, YH, EB 10052231 lymphocyte percentage decreased AE a monocyte percentage abnormal AE that has an outcome of increased monocyte percentage SS, YH, EB 10052230 monocyte percentage increased AE a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the brain SS, YH 10029818 nuclear magnetic resonance imaging brain abnormal AE periorbial edema AE is an edema AE that has an outcome of swelling around the eye. MedDRA: 10034545 is for "periorbital edema"; MedDRA: 10054541 is for "periorbital oedema" SS, YH periorbital oedema AE periorbital puffiness WEB: http://en.wikipedia.org/wiki/Periorbital_puffiness Periorbital puffiness, also known as "puffy eyes" or swelling around the eyes, refers to the appearance of swelling in the tissues around the eyes, called the orbits. periorbital edema AE CTCAE: E13676 NCIt: C78530 UMLS CUI: C0151205 a physical quality of a process that shows a positive result of a pregnancy test. SS, YH 10036556 10036575 pregnancy test positive a blood magnesium abnormal AE that has an outcome of an abnormally high concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors. YH, MW WEB: http://emedicine.medscape.com/article/246489-overview 10020670 hypermagnesemia AE CTCAE: E12288 NCIt: C37969 UMLS CUI: C0151714 a sensory capability AE that has an outcome of a sensation feeling of foreign body SS, YH 10061549 sensation of foreign body AE a sensory capability AE that has an outcome of a sensation feeling of heaviness SS, YH feeling heavy AE sensation of heaviness AE a sensory capability AE that has an outcome of a loss of sensation SS, YH 10040030 sensory loss AE HPO: HP_0003474 SIDER: C0278134 a skin adverse event that has an outcome of skin exfoliation SS, YH 10040844 skin exfoliation AE HPO: HP_0007549 SIDER: C0237849 a digestive system AE which has an outcome of stomach discomfort SS, YH stomach upset AE 胃部不适 10042124 stomach discomfort AE an immunology and allergy investigation result abnormal AE that has an outcome of autoantibodies present DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/autoantibody 10060973 autoantibody positive AE a wheezing AE which has an outcome of stridor, a high pitched wheezing sound resulting from turbulent air flow in the upper airway. It is primarily inspiratory. It can be indicative of serious airway obstruction from severe conditions such as epiglottitis, a foreign body lodged in the airway, or a laryngeal tumor. SS, YH, MW WEB: http://en.wikipedia.org/wiki/Stridor 10042241 stridor AE CTCAE:E13579 HPO: HP_0010307 NCIt:C78632 SIDER: C0038450 a skin AE that shows a result of skin ulcer, i.e., a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. SS, YH, MW skin ulcer AE WEB: http://en.wikipedia.org/wiki/Ulcer_%28dermatology%29 10040943 10040947 skin ulceration AE CTCAE: E13730 HPO: HP_0200042 NCIt: C54247 SIDER: C0037299 an incorrect dose administration that uses underdose SS, YH underdose adminstration in medical intervention a respiratory tract congestion AE which has an outcome of upper respiratory tract congestion SS, YH upper respiratory tract congestion AE a urinary system investigation result abnormal AE that has an outcome of a urine analysis abnormality SS, YH, EB 10062226 urine analysis result abnormal AE a urine analysis result abnomal AE that shows ketone body present in urine SS, YH, EB, QL 10057597 urine ketone body present AE a liver/biliary system AE that has an outcome of inflammation of the liver that occurs when immune cells mistake the liver's normal cells for harmful invaders and attack them DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001291/ 10003827 autoimmune hepatitis AE HPO: HP_0004787 SIDER: C0241910 a hemorrhage AE that has an outcome of vaginal hemorrhage MedDRA: 10046910 is for "vaginal haemorrhage"; MedDRA: 10046912 is for "vaginal hemorrhage" SS, YH, MW vaginal haemorrhage AE WEB: http://www.brooksidepress.org/Products/Military_OBGYN/Textbook/AbnormalBleeding/Bleeding.htm vaginal hemorrhage is irregular/heavy bleeding from the vagina. Vaginal hemorrhage is more often associated with pregnancy complications such as miscarriage or placental abruption, but certainly can occur in the absence of pregnancy. vaginal hemorrhage AE CTCAE: E13264 NCIt: C26945 SS, YH WEB: http://en.wikipedia.org/wiki/Vasodilation a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. vasodilatation AE HPO: HP_0004927 SIDER: C0595862 a bacterial infection AE that has an outcome of bacteria in the blood DJ, SS, YH bacteraemia AE WEB: http://medical-dictionary.thefreedictionary.com/bacteremia 10003997 bacteremia AE a sepsis AE caused by bacterial infection in the bloodstream or body tissues DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sepsis 10053840 bacterial sepsis AE a skin AE that has an outcome of a slow-growing nonmelanoma skin cancer DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001827/ 10004146 basal cell carcinoma AE HPO: HP_0002671 SIDER: C0007117 a basophil count abnormal AE that is characterized by increase in the number of basophils in the body DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/basophil+granulocyte 10004169 basophil count increased AE an ulcer AE that is characterized by ulcers in the mouth that may decrease ocular functionality DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/behcet's+disease 10004213 behcet's syndrome AE a musculoskeletal system AE that has an outcome of low muscle tone DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hypotonia 10051900 benign congenital hypotonia AE a female reproductive system AE that has an outcome of a non-fertilized egg that implants itself in the uterus and turns a normal pregnancy into an abnormal one DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hydatidiform+mole 10004272 benign hydatidiform mole AE a benign tumor AE that has an outcome of a benign tumor in their ovaries DJ, SS, YH benign ovarian tumour AE 10004433 benign ovarian tumor AE a digestive system AE that has an outcome of a blockage in the tubes that carry bile from the liber to the gallbladder and small intestine DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000263.htm 10056375 bile duct obstruction AE a liver/biliary system AE that has an outcome of dilating or stretching of the bile duct DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21843715 10057202 biliary dilatation AE an eating disorder that is characterized by episodes of uncontrollable eating. DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/binge+eating 10004716 binge eating AE an eye disorder AE that has an outcome of binocular eye movement disorder where control and alignment of eyes are compromised DJ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/23201436 Secondary Source: http://brain.oxfordjournals.org/content/119/6/1933.full.pdf 10061010 binocular eye movement disorder AE a digestive system AE that has an outcome of cancer that starts in the bladder, the body part that holds and releases urine in the center of the lower belly area DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001517/ 10005003 bladder cancer AE HPO: HP_0009725 SIDER: C0005684 a blast cell count abnormal AE that has an outcome of an increased amount of immature precursors of either lymphocytes or granulocytes that do not normally appear in peripheral blood. May indicate acute leukemia DJ, SS, YH WEB: http://meds.queensu.ca/medicine/deptmed/hemonc/anemia/blast.htm 10062274 blast cell count increased AE a hematopoietic system AE that has an outcome of a sudden, severe change in the course of chronic granulocytic leukemia with an increase in the proportion of myeloblasts DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/blast+crisis 10053747 blast cell crisis AE a hematopoietic system AE that has an outcome of myeloblasts or myeloid blasts. Presence of these abnormal blasts prevent production of adequate platelets, red blood cells and white blood cells, can be associated with leukemia DJ, SS, YH WEB: http://lymphoma.about.com/od/glossary/ss/Blast-Cells.htm 10057107 blast cells present AE a hematopoietic system AE that has an outcome of the last stage of chronic myelogenous leukemia characterized by rapid progression and short survival with an increase of myeloblasts or lymphoblasts in the blood or bone marrow DJ, SS, YH blast crisis in myelogenous leukaemia AE WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/blast+crisis , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23171293 10050282 blast crisis in myelogenous leukemia AE an eye inflammation AE that has an outcome of swelling in the eyelids, usually where eyelash follicles are located DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002586/ 10005148 blepharitis AE HPO: HP_0000498 SIDER: C0005741 a blood albumin level abnormal AE with an outcome of a decrease in the amount of albumin, a protein made by the liver DJ, SS, YH, EB hypoalbuminemia AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003480.htm 10005287 blood albumin level decreased AE a liver related investigation result abnormal AE that has an outcome of an abnormal level of alkaline phosphatase in the blood DJ, SS, YH, EB 10059571 blood alkaline phosphatase level abnormal AE a blood alkaline phosphatase abnormal AE that has an outcome of a decreased level of alkaline phosphatase in the blood DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase 10059569 blood alkaline phosphatase decreased AE a blood alkaline phosphatase abnormal AE that has an outcome of elevated levels of alkaline phosphatase, an enzyme responsible for removing phosphate groups. a liver/biliary system AE that has an outcome of an increased amount of ALP, an isoenzyme that removes phosphate groups commonly found in the bile ducts but also found in the bone DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase 10001675 10059570 blood alkaline phosphatase increased AE CTCAE: E12082 HPO: HP_0003155 NCIt: C35607 SIDER: C0852911 a distal neuropathy AE which shows a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. It is caused by the loss of myelin sheath of the peripheral nerves. AG, YH CIDP Chronic Inflammatory Demyelinating Polyneuropathy WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm chronic inflammatory demyelinating neuropathy AE a blood amylase level abnormal AE that has an outcome of an increased amount of amylase, an enzyme that helps digest carbohydrates; may indicate disease or inflammation of the pancreas DJ, SS, YH, EB serum amylase increased AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003464.htm 10005328 10040139 blood amylase level increased AE CTCAE: E12212 NCIt: C78608 a liver related investigation result abnormal AE that has an outcome of an abnormal amount of bilirubin in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/bilirubin 10058477 blood bilirubin level abnormal AE a blood bilirubin level abnormal AE with an outcome of a increased amount of bilirubin, or a yellow breakdown product (broken down hemoglobin) of normal heme catabolism, in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/bilirubin 10005364 blood bilirubin level increased AE CTCAE: E12096 NCIt: C27088 a physical quality that has a decreased amount of calcium in the bloodstream DJ, SS, YH 10005395 blood calcium decreased A physical quality that has an decreased level of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease DJ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=9940 10005419 blood chloride decreased HPO: HP_0003113 SIDER: C0595902 a blood cholesterol abnormal AE with the result of an increase in cholesterol level in the blood DJ, SS, YH, EB 10005425 blood cholesterol increased AE CTCAE: E12127 HPO: HP_0003124 NCIt: C37967 SIDER: C0595930 an enzyme investigation result abnormal AE that has an outcome of abnormal levels of creatine phosphokinase in the blood DJ, SS, YH, EB 10005468 blood creatine phosphokinase level abnormal AE a blood creatinine level abnormal AE that has an outcome of an increased level of creatinine in the blood (due to lack of kidney activity) DJ, SS, YH, EB creatinine increased AE serum creatinine increased WEB: http://medical-dictionary.thefreedictionary.com/creatinine 10005483 10011368 blood creatinine level increased AE CTCAE: E12137 NCIt: C78249 an infection adverse event that has an outcome of bacteria or yeasts in the blood DJ, SS, YH WEB: http://labtestsonline.org/understanding/analytes/blood-culture/tab/test 10005488 blood culture positive AE a hematopoietic system AE that has an outcome of disease in the blood, a living tissue made up of plasma and red blood cells, white blood cells and platelets. Blood disorders affect one or more parts of the blood and prevent the blood from doing this job. DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/blooddisorders.html 10061590 blood disorder AE a blood folate abnormal AE that has an outcome of a decreased level of folate in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/folate 10005527 blood folate level decreased AE a blood glucose level abnormal AE that has an outcome of a decrease of glucose levels in blood DJ, SS, YH, EB 10005555 blood glucose level decreased AE a blood glucose level abnormal AE that has an outcome of an increased glucose level in blood DJ, SS, YH, EB 10005557 blood glucose level increased AE a blood homocysteine level abnormal AE that has an outcome of an increased levels of homocysteine in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/homocysteine 10049733 blood homocysteine level increased AE an immunology and allergy investigation result abnormal AE that results in an increased immunoglobulin a level in the blood DJ, SS, YH, EB IgA level increased WEB: http://medical-dictionary.thefreedictionary.com/immunoglobulin+A 10005586 blood immunoglobulin A level increased AE a blood lactate dehydrogenase level abnormal AE that has an outcome of an increased amount of LDH, an enzyme that could indicate tissue damage DJ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm 10005630 blood lactate dehydrogenase level increased AE A physical quality that has an decreased level of magnesium, a mineral involved in nerve signaling and bone health. Deficiency can cause spasms, and muscular cramps. DJ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=4243 10005654 blood magnesium decreased HPO: HP_0002917 SIDER: C0853750 a blood parathyroid hormone level abnormal AE that has an outcome of a decrease in the level of parathyroid hormone in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/parathyroid+hormone 10005702 blood parathyroid hormone decreased AE A physical quality that has an decreased level of decreased phosphorus in the blood DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003478.htm 10049471 blood phosphorus decreased HPO: HP_0002148 SIDER: C0877517 a physical quality where the blood potassium level is decreased. DJ, SS, YH, LW, MW 血钾下降 10005724 blood potassium decreased HPO: HP_0002900 a hypotension AE that has an outcome of a decrease in the amount of pressure in the arteries when the heart is at rest between beats DJ, SS, YH WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes 10005737 blood pressure diastolic decreased AE a hypotension AE that has an outcome of immeasurable blood pressure DJ, SS, YH 10005748 blood pressure immeasurable AE A physical quality that has an decreased level of sodium concentration in the blood DJ, SS, YH, MW 10005802 blood sodium decreased a blood thromboplastin level abnormal AE that has an outcome of an increase in the level of thromboplastin in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/thromboplastin 10005827 blood thromboplastin level increased AE a blood urea level abnormal AE with an outcome of a decreased amount of urea nitrogen in the blood, below 7 to 21 mg of urea per 100 ml DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/blood+urea+nitrogen 10005850 blood urea level decreased AE a blood urea level abnormal AE that results in an increase in amount of urea in blood DJ, SS, YH, EB 10005851 blood urea level increased AE a blood uric acid level abnormal AE that has an outcome of an increase in uric acid in the blood; excess purines may accumulate in tissues and form crystals DJ, SS, YH, EB WEB: http://chemocare.com/chemotherapy/side-effects/hyperuricemia-high-uric-acid.aspx 10005861 blood uric acid level increased AE a bone disorder AE that has an outcome of a cyst that forms on the bone DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/bone+cyst 10005952 bone cyst AE a bone disorder AE that has an outcome of surgery to clean and flush out the infected bone DJ, SS, YH WEB: http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Osteomyelitis 10057612 bone debridement AE a bone disorder AE that has an outcome of an anomlay in the growth or structure of a bone DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/20972590 10061728 bone lesion AE a bone marrow disorder AE that has an outcome of an abnormal condition in which the bone marrow is unable to produce normal amounts of red blood cells, white blood cells and platelets DJ, SS, YH, MW bone marrrow hypocellular hypocellular bone marrow WEB: http://en.diagnosispro.com/differential_diagnosis-for/bx-bone-marrow-biopsy-hypocellular/29777-154.html WEB: http://www.drugs.com/condition/bone-marrow-depression-low-blood-counts.html 10005986 10048580 Bone marrow produces three types of blood cells; red blood cells, white blood cells and platelets. Bone marrow depression is characterized by an inability or reduced ability of the bone marrow to produce these cells. A low blood count can involve just one or all three types of blood cells. bone marrow depression AE CTCAE: E10022 HPO: HP_0012145 NCIt: C35167 SIDER: C0151773 UMLS: C0151773 a hematopoietic system AE that has an outcome of disease in the bone marrow, the spongy tissue inside of some bones that contain stem cells that can develop into red blood cells, white blood cells or platelets DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html 10061729 bone marrow disorder AE a bone marrow disorder AE that has an outcome of an insufficient amount of red blood cells, white blood cells or platelets, associated with fanconii anemia, dyskeratosis congenita, and aplastic anemia DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23271412 10065553 bone marrow failure AE a bone marrow disorder AE that has an outcome of an excess formation of connective tissue in the bone marrow DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22246040 10069678 bone marrow reticulin fibrosis AE a bone marrow disorder AE that has an outcome of the decrease in cells responsible for providing immunity, carrying oxygen and blood clotting DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/12806941 10051779 bone marrow toxicity AE HPO: HP_0005561 SIDER: C0948168 a bone marrow disorder AE that has an outcome of the replacement of damaged bone marrow with healthy bone marrow stem cells DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003009.htm 10061730 bone marrow transplant AE a swelling AE that results in swelling around a bone DJ, SS, YH 10053631 bone swelling AE a skin adverse event that has an outcome of an early stage of squamous cell carcinoma DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/bowen's+disease 10006059 bowen's disease AE a bradycardia AE that results in a decreased heart rate in a neonate DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/10822186 10056471 bradycardia neonatal AE HPO: HP_0001662 SIDER: C1112488 an edema AE that has an outcome of edema or swelling of the extravascular compartment from uptake of water in the gray and white matter DJ, SS, YH brain oedema AE WEB: http://medical-dictionary.thefreedictionary.com/cerebral+edema 10048962 brain edema AE HPO: HP_0002181 SIDER: C1527311 a tumor AE that has an outcome of cancer in the breast DJ, SS, YH 10006187 breast cancer AE HPO: HP_0003002 SIDER: C0006142 a breast cancer AE that has an outcome of cancerous cells spreading to the breast DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001911/ 10055113 breast cancer metastatic AE a breast cancer AE that has an outcome of breast cancer at the stage III level DJ, SS, YH 10006201 breast cancer stage iii AE an infection AE that results in the breast becoming infected DJ, SS, YH 10006259 breast infection AE CTCAE: E11318 HPO: HP_0002726 NCIt: C53662 SIDER: C0392317 a pain AE that results in pain in the breast DJ, SS, YH, MW 10006298 breast pain AE CTCAE:E13073 HPO: HP_0000769 NCIt:C78223 SIDER: C0024902 a reproductive system AE that has an outcome of pain or discomfort in the breast, may be caused by small benign tumors DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21979747 10006313 breast tenderness AE HPO: HP_0100749 SIDER: C0262397 a pneumonia AE that has an outcome of acute inflammation of the walls of the smaller bronchial tubes, with irregular areas of consolidation due to spread of inflammation into peribronchiolar alveoli and the alveolar ducts of the lungs DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/bronchopneumonia 10006469 bronchopneumonia AE HPO: HP_0006538 SIDER: C0006285 an immune system disorder AE that has an outcome of an exaggerated response of the immune system to the fungus Aspergillus DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/bronchopulmonary+aspergillosis 10006473 bronchopulmonary aspergillosis AE HPO: HP_0002724 SIDER: C2350530 a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/bronchospasm 10006482 bronchospasm AE CTCAE:E13352 HPO: HP_0002099 NCIt:C34439 SIDER: C0006266 a sensory capability AE that results in a feeling of burning DJ, SS, YH 10006784 burning sensation AE a syndrom AE that has an outcome of a wasting syndrome characterized by weight loss, muscle atrophy, fatigue, and loss of appetite, often occurs with cancer. DJ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Wasting+Syndrome Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23279159 10006895 cachexia AE HPO: HP_0004326 SIDER: C0006625 a digestive system AE that has an outcome of inflammation of the caecum, part of the large intestine DJ, SS, YH caecitis AE typhlitis AE WEB: http://medical-dictionary.thefreedictionary.com/caecitis 10006919 10045271 cecitis AE CTCAE: E11058 NCIt: C38043 an endocrine system AE that has an outcome of deficiency of calcium in the body DJ, SS, YH 10006956 calcium deficiency AE a cardiovascular disorder AE that has an outcome of self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the circulatory system to the interstitial space, resulting in hypotension, hemoconcentration, and hypoalbuminemia DJ, SS, YH, MW Clarkson's Disease AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/22873043 10007196 capillary leak syndrome AE CTCAE:E13766 NCIt:C62578 a cytogenetic investigation result abnormal AE that has an outcome of an increase in a type of protein typically associated with tumors and the developing fetus DJ, SS, YH, EB WEB: http://www.medicinenet.com/carcinoembryonic_antigen/article.htm 10007266 carcinoembryonic antigen increased AE a tumor AE that has an outcome of a carcinoid tumor that forms somewhere in the body DJ, SS, YH carcinoid tumour AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307266 10007275 carcinoid tumor AE HPO: HP_0006723 SIDER: C0007095 a blood chloride abnormal AE with an outcome of decrease in amount of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease YH, MW WEB: https://en.wikipedia.org/wiki/Hypochloremia 10020957 hypochloremia AE HPO: HP_0003113 UMLS CUI: C0085680 a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body DJ, SS, YH heart failure WEB: http://medical-dictionary.thefreedictionary.com/cardiac+failure 10007554 10019279 cardiac failure AE CTCAE: E10124 HPO: HP_0001635 NCIt: C50577 SIDER: C0018801 a cardiovascular disorder AE that results in an inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body DJ, SS, YH congestive heart failure WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/congestive+heart+failure Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/21676684 10007559 cardiac failure congestive AE HPO: HP_0001635 SIDER: C0018802 a surgery that implants a cardiac pacemaker, a device that supplies electrical impulses to the heart to maintain the heartbeat at a regular rate DJ, SS, YH WEB: http://www.mdguidelines.com/cardiac-pacemaker-insertion 10007598 cardiac pacemaker insertion a cardiac disorder AE that has an outcome of disease involving one or more of the valves of the heart DJ, SS, YH valvular disease AE WEB: http://medical-dictionary.thefreedictionary.com/valvular+heart+disease 10061406 cardiac valve disease AE HPO: HP_0001654 SIDER: C0018824 a cardiac disorder AE that has an outcome of a disorder involving the ventricle(s) in the heart DJ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/ventricular Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/15473469 10057455 cardiac ventricular disorder AE a hypotension AE that has an outcome of the inability of the heart to supply enough blood to the organs of the body because of heart damage DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001237/ 10007625 cardiogenic shock AE a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy WEB: https://en.wikipedia.org/wiki/Cardiomyopathy 10007636 cardiomyopathy AE HPO: HP_0001638 SIDER: C0878544 a cardiovascular disorder AE that has an outcome of heart electrophysiology dysfunction and/or muscle damage. Is not efficient at pumping/circulating blood DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy 10048610 cardiotoxicity AE a coronary artery disorder AE that results in lesion in carotid artery DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/8198401 10067116 carotid arteriosclerosis AE a musculoskeletal system AE that has an outcome of loss of muscle tone due to emotional responses like laughing and crying DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/cataplexy 10007737 cataplexy AE HPO: HP_0002524 SIDER: C0007384 a eye disorder AE that results in cloudiness that develops in the eye DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/cataract 10007739 cataract AE CTCAE: E10350 HPO: HP_0000518 NCIt: C26713 SIDER: C0086543 a sugery AE that has an adverse outcome related to the use of catheter, a thin tube inserted in the body DJ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23306712 10052253 catheter related complication AE an infection AE that has an outcome of an infection (e.g., bacterial colonisation) at the catheter site DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/8825104 10007810 10056520 catheter related infection AE CTCAE: E11328 HPO: HP_0002719 NCIt: C78232 SIDER: C0860239 a bacterial infection AE that is located at the catheter site DJ, SS, YH 10056520 catheter site infection AE a sugery AE that has an adverse outcome at the site where a catheter was used DJ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23074085 10007811 catheter site related reaction AE a cardiac disorder AE that has an outcome of a problem after inserting a catheter into the heart DJ, SS, YH catheterisation cardiac abnormal AE WEB: http://medical-dictionary.thefreedictionary.com/cardiac+catheterization 10007816 catheterization cardiac abnormal AE a behavior and neurological AE that has an outcome of an acute loss of function of the lumbar plexus DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23230403 10007821 cauda equina syndrome AE a bacterial infection AE that is located at the central-line catheter site DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/7580945 10054192 central line infection AE HPO: HP_0002719 SIDER: C1096243 an infection AE that is located in the central nervous system DJ, SS, YH 10061036 central nervous system infection AE HPO: HP_0005381 SIDER: C0007684 a tumor AE that has an outcome of lymphoma in the central nervous system DJ, SS, YH 10007953 central nervous system lymphoma AE an ataxia AE that is located in the cerebellum DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23283615 10008025 cerebellar ataxia AE HPO: HP_0001251 SIDER: C0007758 a brain disorder AE that has an outcome of an inherited brain disorder that affects muscle coordination, may involve the tendency for limb movements to overshoot or undershoot a target, tremors and impaired rhythm DJ, SS, YH WEB: http://www.rightdiagnosis.com/medical/cerebellar_syndrome.htm 10008072 cerebellar syndrome AE HPO: HP_0001317 SIDER: C0007760 a brain disorder AE with the outcome of hemorrhage or blood in the brain DJ, SS, YH cerebral haemorrhage AE 10008111 cerebral hemorrhage AE HPO: HP_0001342 SIDER: C2937358 a brain disorder AE that results in the sudden death of brain cells in a localized area due to inadequate blood flow DJ, SS, YH cerebral ischaemia AE ischemic stroke AE WEB: http://medical-dictionary.thefreedictionary.com/Cerebral+ischaemia 10008120 cerebral ischemia AE HPO: HP_0002637 SIDER: C0917798 a nervous system AE that has an outcome of pain or another sensation in the patient's neck and shoulder region DJ, SS, YH WEB: http://www.mdguidelines.com/cervicobrachial-syndrome/definition 10008334 cervicobrachial syndrome AE a skin AE that has an outcome of dry lips caused by the evaporation of moisture. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/9433089 10049047 chapped lips AE an inflammation AE that occurs in the lip DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/cheilitis 10008417 cheilitis AE CTCAE: E10517 HPO: HP_0100825 NCIt: C79545 SIDER: C0007971 a skin AE that has an outcome of a burn due to chemicals on the skin DJ, SS, YH 10057941 chemical burn of skin AE a discomfort AE that has an outcome of pain in the chest DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/chest+pain 10008469 chest discomfort AE HPO: HP_0001681 SIDER: C0235710 alcohol cardiomyopathy AE a progressive tumor AE that has an outcome of multiple, malignant, localized green masses of abnormal cells, usually myeloblasts, especially beneath the periosteum of the skull, spine and ribs DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/chloroma 10008583 chloroma AE a digestive system AE that has an outcome of infection in the common bile duct, usually by bacterial infection DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001335/ 10008604 cholangitis AE HPO: HP_0011040 SIDER: NA a liver/biliary system AE that has an outcome of a condition in which the flow of bile from the liver is slowed or blocked DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001263/ 10008635 cholestasis AE HPO: HP_0001396 SIDER: C0008370 an adverse event that has an outcome of calcium crystals of calcium pyrophosphate dihydrate accumulated in the connective tissues of the patient DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/chondrocalcinosis 10008690 chondrocalcinosis pyrophosphate AE a cytogenetic investigation result abnormal AE that has an outcome of an abnormal chromosome pattern DJ, SS, YH, EB WEB: http://www.miscarriageclinic.co.uk/causes-and-treatments/chromosome-abnormality/ 10008817 chromosome analysis abnormal AE a peripheral neuropathy AE which has an outcome of a chemotherapy-induced neuropathy that affects nerves of the peripheral nervous system (PNS) AG, YH CIPN WEB: http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/chemotherapyeffects/peripheralneuropathy/peripheral-neuropathy-caused-by-chemotherapy-what-is-cipn chemotherapy-induced peripheral neuropathy AE a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by increased and unregulated growth of myeloid cells in the bone marrow DJ, SS, YH chronic myeloid leukaemia AE WEB: http://medical-dictionary.thefreedictionary.com/chronic+myelogenous+leukemia 10009013 chronic myeloid leukemia AE HPO: HP_0005506 SIDER: C0023473 a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. May transform from chronic myeloid leukaemia to acute myeloid leukaemia DJ, SS, YH chronic myeloid leukaemia transformation AE WEB: http://www.jci.org/articles/view/41246 10068232 chronic myeloid leukemia transformation AE a lung disorder AE that has an outcome of breathing difficulty with two main forms: chronic bronchitis and emphysema DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001153/ 10009033 chronic obstructive pulmonary disease AE HPO: HP_0006510 SIDER: C0024117 a respiratory system AE that results in inadequate gas exchange by the respiratory system DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/respiratory+failure 10009126 chronic respiratory failure AE a respiratory system AE that has an outcome of inflammation in the cavities around the nasal passages DJ, SS, YH WEB: http://www.mayoclinic.com/health/chronic-sinusitis/DS00232 10009137 chronic sinusitis AE a lung disorder AE that has an outcome of lymphatic fluid accumulating in the pleural cavity, the space between two pleura of the lungs DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/chylothorax 10051228 chylothorax AE CTCAE:E13358 NCIt:C79546 a cardiovascular disorder AE that has an outcome of insufficient circulation without congestive heart failure DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/circulatory+collapse 10009192 circulatory collapse AE a bacterial infection AE that has an outcome of invasion by anaerobic bacteria of the genus Clostridium, can cause tetanus and botulism DJ, SS, YH WEB: http://www.medicinenet.com/clostridium_difficile_colitis/page2.htm 10061043 clostridial infection AE HPO: HP_0004798 SIDER: C0009062 a digestive system AE that has an outcome of bacterial infection by clostridium difficile colitis, commonly results in diarrhea and colitis DJ, SS, YH 10009657 clostridium difficile colitis AE HPO: HP_0002583 SIDER: C0238106 a coagulation factor v level abnormal AE that has an outcome of a decreased level of the factor V protein in the coagulation system of the body DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/22781721 10009754 coagulation factor v level decreased AE an inflammation AE that occurs at the large intestine DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002112/ 10009887 colitis AE CTCAE: E10521 HPO: HP_0002583 NCIt: C26723 SIDER: C0009319 a lung disorder AE that has an outcome of a collapsed lung, refering to the space between the wall of the chest cavity and the lung filling with air, causing all or a portion of the lung to collapse DJ, SS, YH Pneumothorax 10009913 collapse of lung AE a tumor AE that has an outcome of cancer that starts in the large intestine or the rectum DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/ 10009944 colon cancer AE HPO: HP_0003003 SIDER: C0007102 a colon AE that has an outcome of cancerous cells spreading to the colon DJ, SS, YH WEB: http://www.cancer.gov/cancertopics/factsheet/Sites-Types/metastatic 10055114 colon cancer metastatic AE a colon cancer AE that has an outcome of colon cancer at stage IV DJ, SS, YH 10009956 colon cancer stage iv AE a digestive system AE that has an outcome of cancer that starts in the large intestine or rectum. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/ 10061451 colorectal cancer AE HPO: HP_0003003 SIDER: C1527249 a digestive system AE that has an outcome of cancer in the large intestine and the rectum. When metastatic, the cancer has already spead to distant sites and is considered stage IV. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22642873 10052358 colorectal cancer metastatic AE HPO: HP_0003003 SIDER: C0948380 an imaging investigation result abnormal AE that has an abnormal result of an imaging method in which a cross-sectional image of the structures in a body plane is reconstructed by a computer program from the x-ray absorption of beams projected through the body in the image plane DJ, SS, YH, EB computerised tomogram abnormal AE WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/computerized+tomography , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23271098 WEB: http://medical-dictionary.thefreedictionary.com/computed+tomography 10010235 computerized tomography result abnormal AE an adverse event that has an outcome of progression of underlying conditions that may affect drug distribution or metabolism DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Concomitant+disease 10048659 concomitant disease progression AE an adverse event that has an outcome of condition that worsens DJ, SS, YH 10010264 condition aggravated AE a congenital abnormality AE that has an outcome of an abnormality in heart which is present at birth DJ, SS, YH WEB: http://www.thefreedictionary.com/congenital+heart+defect 10061054 congenital cardiovascular anomaly AE HPO: HP_0001626 SIDER: C0243050 a cardiomyopathy AE that is characterized by the walls of the heart chambers stretching to hold a greater volume of blood than normal DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/congestive+cardiomyopathy 10056370 congestive cardiomyopathy AE HPO: HP_0001635 SIDER: C0007193 an eye disorder AE that has an outcome of a problem involving the insides of the patient's eyelids DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/conjunctiva 10061446 conjunctival disorder AE HPO: HP_0000502 SIDER: C0009759 a hemorrhage AE that has an outcome of a bright hemorrhagic patch on the bulbar conjunctiva caused by rupture and bleeding of a superficial small capillary due to increased pressure DJ, SS, YH conjunctival haemorrhage AE 10010719 conjunctival hemorrhage AE HPO: HP_0007902 SIDER: C0009760 an adverse event that has an outcome of disease in the biological tissue that supports, binds together and protects organs DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/connective+tissue+disease 10061087 connective tissue disorder AE HPO: HP_0003549 SIDER: C0009782 an eye disorder AE that has a result of the inability to use contact lenses DJ, SS, YH 10010804 contact lens intolerance AE a hematology investigation result abnormal AE that has an outcome of a positive coombs test, which is a blood test that identifies the causes of anemia DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/Coombs'+Tests WEB: http://medical-dictionary.thefreedictionary.com/test 10061090 coombs' test positive AE a behavior and neurological AE that results in a loss of coordination DJ, SS, YH 10010947 coordination abnormal AE HPO: HP_0011443 SIDER: C0520966 a cardiac disorder AE that has an outcome of treatment involving the stenotic coronary arteries in the heart DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/coronary+angioplasty 10050329 coronary angioplasty AE a coronary artery disorder AE that has an outcome of an blockage in the coronary artery DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22953315 10011084 coronary artery embolism AE a coronary artery disorder AE that has an outcome of an insufficient amount of blood circulates through the coronary arteries DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/coronary+insufficiency 10052895 coronary artery insufficiency AE HPO: HP_0001677 SIDER: C0542052 a tumor AE that has an outcome of a brain tumor derived from the embryonic tissue of the pituitary gland DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/craniopharyngioma 10011318 craniopharyngioma AE a c-reactive protein level abnormal AE that has an outcome of an increased amount of CRP, a protein that measure general levels of inflammation in the body DJ, SS, YH, EB WEB: http://www.webmd.com/a-to-z-guides/c-reactive-protein-crp moved "c-reactive protein increased AE" from "cardiac AE" to "lab test abnormal AE" EB 10006825 c-reactive protein level increased AE viral cardiomyopathy AE a nervous system AE that has an outcome of increased pressure in the skull DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/intracranial+pressure 10011570 csf pressure increased AE a urine analysis result abnormal AE that has an outcome of high bacterial colonization counts in the urine DJ, SS, YH, EB WEB: http://labtestsonline.org/understanding/analytes/urine-culture/tab/test 10011640 culture urine positive AE an inflammation AE that has an outcome of inflamed blood vessels in the skin DJ, SS, YH WEB: http://dermnetnz.org/vascular/vasculitis.html 皮肤血管炎 10011686 cutaneous vasculitis AE HPO: HP_0200029 SIDER: C0262988 a urinary system AE that has an outcome of cystitis with severe hemorrhage, a dose-limiting toxic condition with administration of ifosfamide and cyclophosphamide or a complication of bone marrow transplantation DJ, SS, YH cystitis haemorrhagic AE WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+cystitis 10011793 cystitis hemorrhagic AE a genetic disorder AE that has an outcome of an atypical number of chromosomes or a structural abnormality in one or more chromosomes DJ, SS, YH 10067477 cytogenetic abnormality AE an inflammation AE that has an outcome of release of cytokines by T cells that causes inflammation DJ, SS, YH WEB: http://encyclopedia.thefreedictionary.com/cytokine+release+syndrome 10052015 cytokine release syndrome AE CTCAE: E11264 NCIt: C78251 a liver/biliary system AE that has an outcome of liver cells carrying excess water, causing inflammation along with hepatitis DJ, SS, YH WEB: http://www.thirdage.com/hc/c/q/hepatitis/1550008/what-is-cytolytic-hepatitis 10050904 cytolytic hepatitis AE HPO: HP_0004787 SIDER: C0919823 an inflammation AE that results in the inflammation of the colon DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22874621 10048983 cytomegalovirus colitis AE a viral infection AE that is caused by cytomegalovirus DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/cytomegalovirusinfections.html 10011831 cytomegalovirus infection AE HPO: HP_0004429 SIDER: C0010823 a skin AE that has an outcome of shedding of the dead skin cells from the scalp DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/dandruff 10011859 dandruff AE HPO: HP_0001051 SIDER: C0221244 a surgery that performs a medical removal of dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue DJ, SS, YH, SJ WEB: http://medical-dictionary.thefreedictionary.com/Debridement WEB: http://www.surgeryencyclopedia.com/Ce-Fi/Debridement.html 10057612 10067806 debridement a skin ulcer AE that has an outcome of localized injuries to the skin and/or underlying tissue usually over a bony prominence as a result of pressure DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/pressure+ulcer 10011985 decubitus ulcer AE HPO: HP_0200042 SIDER: C0011127 a venous thrombosis that is characterized by a blood clot that forms in a vein deep in the body. Blood clots occur when blood thickens and clumps together. Most deep vein blood clots occur in the lower leg or thigh. They also can occur in other parts of the body. DJ, SS, YH DVT WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/dvt/ Moved from Cardiac AE to thombosis AE by LB 10051055 deep vein thrombosis AE HPO: HP_0004850 SIDER: C0149871 a psychiatric disorder AE that results in a decline in level of cognitive function DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/delirium 10012218 delirium AE CTCAE:E12898 NCIt:C2981 a tooth disorder AE that has an outcome of bacterial infection that causes demineralization and destruction of the hard tissues, resulting in dental cavities DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/dental+caries 10012318 dental caries AE CTCAE: E10568 HPO: HP_0000670 NCIt: C52593 SIDER: C0011334 a sensory capability AE that results in a lower level of arousal than normal DJ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmed/23167919 10012373 depressed level of consciousness AE CTCAE:E12625 HPO: HP_0004372 NCIt:C78253 SIDER: C0549249 a dermatitis ae that is characterized by the eruption of papules and pustules, typically on the face, scalp, upper chest and back. DJ, SS, YH WEB: https://www.medify.com/conditions/acneiform-dermatitis 10012432 dermatitis acneiform AE HPO: HP_0001051 SIDER: C0234894 a dermatitis ae that is characterized by an inflammatory skin disease with erythmea and scaling, that has an outcome of widespread scaling of the skin, often with itching, skin redness and hair loss DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001610.htm 10012455 dermatitis exfoliative AE HPO: HP_0011123 SIDER: C0011606 a muscle AE that has an outcome of muscle weakness, inflammation, skin rash and difficulty swallowing DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001842/ 10012503 dermatomyositis AE a motor neuropathy AE that has an outcome of poor coordination DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001533.htm 10012557 developmental coordination disorder AE an injury and procedural complication AE that results in the dislocation of a device DJ, SS, YH 10064684 device dislocation AE an injury and procedural complication AE that results in the expulsion (vomiting) of medical device from body DJ, SS, YH 10012578 device expulsion AE an injury and procedural complication AE that results in an infection related to medical device DJ, SS, YH 10064687 device related infection AE CTCAE: E11356 HPO: HP_0002719 NCIt: C79705 SIDER: C1619702 a coma AE which is induced by the condition that the patient has extremely high levels of sugar in the blood without ketones DJ, SS, YH diabetic hyperglycaemic coma AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000304.htm 10012668 diabetic hyperglycemic coma AE a respiratory system AE that has an outcome of an abnormal hole in the diaphragm DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23288807 10012713 diaphragmatic hernia AE HPO: HP_0000776 SIDER: C0019284 a paralysis AE that has an outcome of a paralyzed diaphragm DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19452391 10012725 diaphragmatic paralysis AE a diarrhea AE that has an outcome of rectal bleeding and bloody diarrhea DJ, SS, YH diarrhoea haemorrhagic AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/19292138 10012741 diarrhea hemorrhagic AE HPO: HP_0002255 SIDER: C0151594 a diarrhea AE that has an outcome of diarrhea is caused by infection DJ, SS, YH diarrhoea infectious AE 10012742 diarrhea infectious AE a cardiac disorder AE with an outcome of decline in performance of one or both ventricles of the heart during the time phase of diastole, when heart filling with incoming blood DJ, SS, YH WEB: http://encyclopedia.thefreedictionary.com/diastolic+dysfunction 10052337 diastolic dysfunction AE a cardiac ventricular disorder AE that has an outcome of enlargement of a heart chamber that pumps blood away from the heart DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721391/ 10013012 dilatation ventricular AE an adverse event with an outcome of worsening of the disease DJ, SS, YH 10061818 disease progression AE HPO: HP_0004738 SIDER: C0242656 a bone disorder AE that has an outcome of dislocation of vertebra DJ, SS, YH 10013183 dislocation of vertebra AE a sensory capability AE that results in the senses of time, direction, and recognition of people and places becoming difficult to distinguish DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/disorientation 10013395 disorientation AE HPO: HP_0001289 SIDER: C0233407 a hematopoietic system AE with an outcome of a serious disorder in which proteins that control blood clotting become abnormally active DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000573.htm 10013442 disseminated intravascular coagulation AE CTCAE: E10028 HPO: HP_0005521 NCIt: C2992 SIDER: C0012739 a behavior and neurological AE that results in a loss of attention DJ, SS, YH 10013496 disturbance in attention AE HPO: HP_0007018 SIDER: C0233414 a digestive system AE with an outcome of perforation of small sacs or pockets in the wall of the colon DJ, SS, YH WEB: http://www.webmd.com/digestive-disorders/diverticular-disease 10061820 diverticular perforation AE a digestive system AE that has an outcome of infection and inflammation in the small, bulging sacs or pouches of the inner lining of the intestine DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001303/ 10013538 diverticulitis AE HPO: HP_0002253 SIDER: C0012813 a hemorrhage AE that has an outcome of bleeding in the intestine due to diverticulitis DJ, SS, YH diverticulitis intestinal haemorrhagic AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780263/ 10013541 diverticulitis intestinal hemorrhagic AE an adverse event that has an outcome of a decreased amount of the drug excreted by the body DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/drug+clearance 10049463 drug clearance decreased AE an adverse drug event that results in the development of a dependence on the drug DJ, SS, YH 10013663 drug dependence AE HPO: HP_0000722 SIDER: C1510472 a skin AE that has an outcome of a range of adverse drugs reactions of the skin, most commonly rashes resembling measles DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption 10013687 drug eruption AE a hypersensitivity AE that has an outcome of allergic reactions to certain drugs DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23192511 10013700 drug hypersensitivity AE HPO: HP_0100326 SIDER: C0013182 a drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/drug+intolerance 10061822 drug intolerance AE a headache AE that has an outcome of headaches due to drug withdrawal DJ, SS, YH 10013753 drug withdrawal headache AE an adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/withdrawal 10013754 drug withdrawal syndrome AE a skin AE that is characterized by epidermis that lacks moisture, has an outcome of fine lines, scaling and itching DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/dry+skin 10013786 dry skin AE CTCAE:E13623 HPO: HP_0000958 NCIt:C74592 SIDER: C0151908 a duodenum AE that has an outcome of a peptic ulcer, or a defect in the lining of the stomach or the first part of the small intestine, located in the duodenum DJ, SS, YH peptic ulcer AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ 10013836 duodenal ulcer AE CTCAE: E10611 HPO: HP_0002588 NCIt: C26755 SIDER: C0013295 a duodenal ulcer AE with an outcome of bleeding in an ulcer, or a defect, in the lining of the stomach or first part of the small intestine called the duodenum DJ, SS, YH duodenal ulcer haemorrhage AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ 10013839 duodenal ulcer hemorrhage AE HPO: HP_0002588 SIDER: C0151966 a duodenal ulcer AE that has an outcome of perforation, or complete penetration, of an ulcer located in an area of the small intestine called the duodenum DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ 10013849 duodenal ulcer perforation AE HPO: HP_0002588 SIDER: C0740401 a speech disorder that results in a motor speech disorder DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/dysarthria 10013887 dysarthria AE CTCAE:E12635 HPO: HP_0001260 NCIt:C79549 SIDER: C0013362 a behavioral and neurological AE that results in difficulty reading (mixing up letters) DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/dyslexia 10013932 dyslexia AE HPO: HP_0010522 SIDER: C0476254 a speech disorder AE that results in disorders of voice DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/dysphonia 10013952 dysphonia AE HPO: HP_0001618 SIDER: C1527344 a dyspnoea AE that has an outcome of shortness of breath during exercise, produces a sensation of not being able to get enough air DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22760109 10013971 dyspnoea exertional AE HPO: HP_0002875 SIDER: C0231807 Dysuria AE is an urinary system AE that results in painful urination JX, DJ, SS, YH urination disorders AE WEB: http://medical-dictionary.thefreedictionary.com/dysuria 排尿困难 10013990 dysuria AE HPO: HP_0100518 SIDER: C0013428 a gustatory system AE which has an outcome of abrnormal or disturbed eating habits DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/eating+disorder 10014062 eating disorder AE a female reproductive system AE that results in an ectopic pregnancy that occurs along with the use of an IUD DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/ectopic+pregnancy 10067037 ectopic pregnancy with intrauterine device AE a skin AE that has an outcome of a long term skin disorder that involves scaly and itchy rashes DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001856/ 10014184 eczema AE HPO: HP_0000964 SIDER: C0013595 an abnormal fluid regulation AE that has an outcome of escape of a fluid into a part DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/effusion 10063045 effusion AE a male reproductive system AE that has an outcome of a delay of ejaculation DJ, SS, YH 10014325 ejaculation delayed AE HPO: HP_0000022 SIDER: NA a left ventricular dysfunction AE that has an outcome of decreased percentage of blood leaving the heart each time it contracts DJ, SS, YH WEB: http://www.mayoclinic.com/health/ejection-fraction/AN00360 10050528 ejection fraction decreased AE CTCAE: E12142 NCIt: C83492 a cardiac function test abnormal AE that has an outcome of abnormal electrical activity in the heart DJ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003868.htm 10014363 electrocardiogram result abnormal AE an electrocardiogram result abnormal AE that has an outcome of an abnormal depolarization of the right and left ventricles of the heart that is detected on an electrocardiogram test DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23238367 10014378 electrocardiogram qrs complex abnormal AE an electrocardiogram result abnormal AE that has an outcome of a prolonged time between the start of the Q wave and the end of the T wave in the heart's electrical cycle; a biomarker for ventricular tachyarrhythmias DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23275261 10014387 electrocardiogram qt prolonged AE HPO: HP_0001657 SIDER: C0151878 an electrocardiogram result abnormal AE in which the T wave appears increased in amplitude and cresting at a point DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301064; http://www.medaphile.com/medical-dictionary/t-wave-peaked 10014396 electrocardiogram t wave peaked AE a homeostasis AE that has an outcome of abnormalities in electrolytes (sodium, potassium, calcium) DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/electrolyte+imbalance 10014418 electrolyte imbalance AE HPO: HP_0003111 SIDER: C0342579 a psychiatric disorder AE that results in an abnormal expression of emotions DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/emotional+disorder 10014551 emotional disorder AE HPO: HP_0100851 SIDER: C0233459 an inflammation AE that occurs in the inside lining of the heart chambers and heart valves DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002088/ 10014665 endocarditis AE HPO: HP_0100584 SIDER: C0014118 a digestive system AE with an outcome of inflammation in the intestine, especially the small intestine DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/enteritis 10014866 enteritis AE HPO: HP_0004387 SIDER: C0014335 a digestive system AE that has an outcome of disease in the digestive tract caused by infection DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/enterocolitis 10014893 enterocolitis AE CTCAE: E10627 HPO: HP_0004387 NCIt: C79573 SIDER: C0014356 an digestive system AE that has an outcome of an infection by enteric viruses or enterotoxigenic bacterias, usually in the intestines, that presents with diarrhea, abdominal pain, perianal discomfort, incontinence and hemorrhage. DJ, SS, YH WEB: http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0792-2..50022-5--cesec139&isbn=978-1-4377-0792-2&type=bookPage&from=content&uniqId=376758653-2 10058838 enterocolitis infectious AE an eosinophil count abnormal AE that has an outcome of an increased amount of eosinophils, a type of white blood cell that becomes active with allergic diseases and infections DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003649.htm 10014945 eosinophil count increased AE HPO: HP_0001880 SIDER: C2240374 a hematopoietic system AE that has an outcome of higher than normal levels of eosinophils, a type of white blood cell DJ, SS, YH WEB: http://www.mayoclinic.com/health/eosinophilia/MY00399 10014950 eosinophilia AE HPO: HP_0001880 SIDER: C0014457 a male reproductive system AE that results in the inability to develop/maintain an erection of penis DJ, SS, JX, LW, YH, MW astyphia AE impotence AE WEB: http://en.wikipedia.org/wiki/Erectile_dysfunction 阳痿/勃起功能障碍 10061461 erectile dysfunction AE CTCAE:E13088 HPO: HP_0008652 NCIt:C3133 SIDER: C0242350 a skin AE that has an outcome of an infection caused by a Streptococcus bacteria that causes blisters, fever and skin lesion and sores DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001643/ 10015145 erysipelas AE HPO: HP_0001055 SIDER: C0014733 a psoriasis AE that has an outcome of psoriasis that affects all sites on the body DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/psoriatic+erythroderma 10015278 erythrodermic psoriasis AE a bacterial infection AE with an outcome of invasion by Escherichia coli bacteria, commonly found in the lower intestine and can cause serious food poisoning, but can also be found in various parts of body DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/escherichia+coli 10061126 escherichia infection AE a microbiology and serology investigation result abnormal AE that has an outcome of a positive escherichia test DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/Escherichia 10070090 escherichia test positive AE an urinary tract infection AE that has an outcome of infection caused by E. coli bacteria DJ, SS, YH WEB: http://www.medicinenet.com/urine_infection/article.htm 10052238 escherichia urinary tract infection AE a connective tissue AE that has an outcome of excess perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19594571 10063560 excessive granulation tissue AE a rash AE that has an outcome of erythema, desquamation, scaling, itching of the skin and loss of hair DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/exfoliative+dermatitis 10064579 exfoliative rash AE a congenital abnormality that results in a weakness of the baby's abdominal wall where the umbilical cord joins it. This weakness allows the abdominal contents to protrude outside the abdominal cavity DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/exomphalos 10015677 exomphalos AE HPO: HP_0001539 SIDER: C1306503 an injury and procedural complication AE that results in the patient being exposed to a contaminated device DJ, SS, YH 10068515 exposure to contaminated device AE a procedural complication AE that results in the patient being exposed to a toxic agent DJ, SS, YH 10053487 exposure to toxic agent AE an abscess AE that results in a collection of pus between a person's skull and dura DJ, SS, YH WEB: http://www.meb.uni-bonn.de/dtc/primsurg/docbook/html/x1217.html 10061846 extradural abscess AE a paresis AE that results in a partial loss of voluntary movement in their extraocular muscles DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22824489 10015829 extraocular muscle paresis AE CTCAE: E10367 NCIt: C78286 coagulopathy AE results in the impairment of blood to clot causing ecessive or prolonged bleeding. SJ, YH bleeding disorder clotting disorder WEB: http://en.wikipedia.org/wiki/Coagulopathy 10009802 coagulopathy AE a hemorrhage AE that has an outcome of hemorrhage occuring in the blood vessels in the eye DJ, SS, YH eye haemorrhage AE subconjunctival haemorrhage AE WEB: http://www.webmd.com/eye-health/bleeding-in-the-eye 10015926 eye hemorrhage AE HPO: HP_0011885 SIDER: C0015402 a eye disorder AE that has an outcome of swelling in the tissues around the eyes, called the orbits, caused by fluid buildup DJ, SS, YH perioribtal puffiness AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/21115963 10015967 eye swelling AE an eye edema AE that has an outcome of swelling in either or both the lower and upper eyelids, due to fluid buildup or inflammation in the delicate tissues surrounding the eye. DJ, SS, YH eyelid oedema AE WEB: http://www.localhealth.com/article/eyelid-swelling 10015993 eyelid edema AE HPO: HP_0100539 SIDER: C0162285 A pregnancy, neonatal and perinatal AE that displays the result of failure to thrive (FTT), which refers to a baby or child that is not developing as well as desired. DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000991.htm WEB: http://www.stanfordchildrens.org/en/topic/default?id=failure-to-thrive-90-P02297 10016165 failure to thrive AE HPO: HP_0001531 SIDER: C0015544 a behavior and neurological AE that has an outcome of patient falling DJ, SS, YH 10016173 fall AE CTCAE: E11687 HPO: HP_0002359 NCIt: C50558 SIDER: C0085639 a behavior and neurological AE that results in the extreme fear of needles DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23225704 10068298 fear of needles AE a hematopoietic system AE that has an outcome of inadequate blood cell formation by bone marrow accompanied by a fever DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Bone+marrow+aplasia 10053213 febrile bone marrow aplasia AE a fever AE that has an outcome of an infection along/because of a fever DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/febrile 10051998 febrile infection AE a neutropenia AE, generally a complication of chemotherapy, that has an outcome of an abnormally low neutrophil granulocyte count, accompanied by fever DJ, SS, YH neutropenic sepsis AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23303687 10016288 febrile neutropenia AE CTCAE: E10033 HPO: HP_0001875 NCIt: C35665 SIDER: C0746883 an injury and procedural complication AE that has an outcome of an complication due to the use of enteral feeding tube DJ, SS, YH enteral feeding AE WEB: http://www.thirdage.com/hc/p/197842/what-is-tube-feeding 10056661 feeding tube complication AE a sensory capabilty AE that results in the patient feeling different than normal after a medical intervention such as taking drug DJ, SS, YH 10016322 feeling abnormal AE HPO: HP_0010870 SIDER: C1443060 Feeling hot AE is a feeling abnormal AE that a patient feels hot. DJ, SS, YH 10016334 feeling hot AE a hypoaesthesia AE that has an outcome of a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli in the oral area SS, YH hypoaesthesia oral AE WEB: http://en.wikipedia.org/wiki/Hypoesthesia 10057371 hypoesthesia oral AE HPO: HP_0010830 SIDER: C0521592 a fistula AE that has an outcome of discharge that occurs as the result of the connection between two body cavities DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed?term=fistula%20discharge%20%5BTI%5D 10067143 fistula discharge AE an abnormal fluid regulation AE with an outcome of decrease in ingestion of water or other fluids DJ, SS, YH 10056291 fluid intake reduced AE a hematopoietic system AE that has an outcome of too much fluid in the blood, can occur due to increase in total body sodium DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22827112 10016803 fluid overload AE a hyperplasia AE that has an outcome of a benign tumor in the liver DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/focal+nodular+hyperplasia 10052285 focal nodular hyperplasia AE a congenital abnormality disorder AE that has an outcome of a decreased heart rate in a fetus DJ, SS, YH foetal heart rate deceleration AE 10058322 fetal heart rate deceleration AE a skin AE with the outcome disease involving of one more more hair follicles, commonly displays rash, itching and pustules near the hair follicles DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001826/ 10016936 folliculitis AE a respiratory system AE that has an outcome of a decreased volume of air expired from the lungs DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/forced+expiratory+volume 10016987 forced expiratory volume decreased AE CTCAE: E12156 NCIt: C50524 a bone disorder AE that has an outcome of fracture located in the arm DJ, SS, YH 10016997 forearm fracture AE a bone disorder AE that has an outcome of complete or incomplete break in a bone resulting from the application of excessive force DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Fractures 10017076 fracture AE CTCAE: E11703 NCIt: C3046 a full blood count abnormal AE that has an outcome of a decrease in full blood cell count DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/full+blood+count 10017413 full blood count decreased AE a digestive system AE that has an outcome of inflammation in the esophagus due to fungus DJ, SS, YH fungal oesophagitis AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/ 10049656 fungal esophagitis AE a digestive system AE that has an outcome of an abnormal enlargement in the size of the gallbladder DJ, SS, YH 10062693 gallbladder enlargement AE a digestive system AE that has an outcome of an abnormal hole in the patient's gallbladder DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/gallbladder+perforation 10017639 gallbladder perforation AE CTCAE: E11208 NCIt: C78309 a digestive system AE that has an outcome of an abnormal growth (accumulation of mucous membrane tissue) in the gallbladder DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19556839 10049704 gallbladder polyp AE an arrhythmia AE that results in an abnormal heart sound DJ, SS, YH WEB: http://circ.ahajournals.org/content/20/6/1053.full.pdf 10017648 gallop rhythm present AE a liver related investigation result abnormal AE that has an outcome of an abnormal level of gamma-glutamyltransferase (GGT); GGT is involved in the transfer of amino acids across the cellular membrane DJ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003458.htm 10017688 gamma-glutamyltransferase level abnormal AE a gamma-glutamyltransferase level abnormal AE that has an outcome of an increase in gamma-glutamyltransferase enzyme presence in the liver DJ, SS, YH, EB GGT increased WEB: http://www.ncbi.nlm.nih.gov/pubmed/23258530 10017693 10056910 gamma-glutamyltransferase level increased AE CTCAE: E12161 NCIt: C26943 a gastric disorder AE that has an outcome of cancer that starts in the stomach DJ, SS, YH 10017758 gastric cancer AE HPO: HP_0006753 SIDER: C0024623 a tumor AE that has an outcome of cancer in the stomach DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/stomach+cancer 10061968 gastric neoplasm AE a gastric disorder AE that has an outcome of a defect in the lining of the stomach DJ, SS, YH 胃溃疡 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ 10017822 gastric ulcer AE CTCAE: E10727 HPO: HP_0002592 NCIt: C3388 SIDER: C0038358 a gastric disorder AE that has an outcome of inflammation in the lining of the stomach DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002135/ 10017853 gastritis AE CTCAE: E10733 HPO: HP_0005263 NCIt: C26780 SIDER: C0017152 a gastritis AE that has an outcome of inflammation in the stomach mucosa DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/2789800 10017860 gastritis atrophic AE a gastritis AE that has an outcome of gastric mucosal erosion caused by damage to mucosal defences DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/gastritis 10017865 gastritis erosive AE HPO: HP_0005263 SIDER: C2243088 ischemic colitis AE is a gastrointestinal disorder AE that results in injury and inflammation of the large intestine due to inadequate blood supply. SJ, YH WEB: http://en.wikipedia.org/wiki/Ischemic_colitis 10009896 ischemic colitis AE a gastroenteritis AE that has an outcome of disease caused by the norovirus DJ, SS, YH WEB: http://www.cdc.gov/ncidod/dvrd/revb/gastro/faq.htm 10068189 gastroenteritis norovirus AE a gastroenteritis AE that has an outcome of disease due to radiation DJ, SS, YH 10017912 gastroenteritis radiation AE a digestive system AE that results in mucosal damage caused by acid from stomach coming up to the esophagus DJ, SS, YH GERD AE esophageal reflux AE gastrooesophageal reflux disease AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301861 10017885 10066874 gastroesophageal reflux disease AE CTCAE: E10739 NCIt: C26781 a gastrointestinal disorder AE with an outcome of infection in the digestive tract caused by bacteria, viruses or parasites DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Gastrointestinal+infection 10017964 gastrointestinal infection AE HPO: HP_0004798 SIDER: C1264613 a gastrointestinal disoder AE that has an outcome of an injury in the gastrointestinal area DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23207874 10061172 gastrointestinal injury AE a gastrointestinal disoder AE that has an outcome of premature death in cells of living tissue in the stomach and intestines DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/necrosis 10017982 gastrointestinal necrosis AE an adverse event induced by administration of a bupropion drug YH bupropion-induced adverse event a gastrointestinal disorder AE that results in a hole in the wall of the esophagus, stomch, small intestine, large bowel, rectum or gallbladder DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/ 10018001 gastrointestinal perforation AE HPO: HP_0011024 SIDER: C0151664 a tumor AE that has an outcome of a tumor in the gastrointestinal tract, thought to grow from specialized cells found in the tract called interstitial cells of Cajal DJ, SS, YH gastrointestinal stromal tumour AE WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor 10051066 gastrointestinal stromal tumor AE HPO: HP_0007378 SIDER: C0238198 a gastrointestinal disorder AE that has an outcome of poison affecting the stomach and/or intestinal tracts, often accompanied by abdominal pain, diarrhea and vomiting DJ, SS, YH WEB: http://www.theodora.com/drugs/valcyte_tablets_roche_laboratories.html 10059024 gastrointestinal toxicity AE HPO: HP_0011024 SIDER: C1142499 a cytogenetic investigation result abnormal AE that has an outcome of a positive test for gene mutation, deletions and duplications that could indicate large disease risk DJ, SS, YH, EB WEB: https://www.duchenneconnect.org/index.php?option=com_content&view=article&id=346&Itemid=392&lang=en 10063478 gene mutation identification test positive AE a systematic adverse event that has an outcome of worsening of physical health DJ, SS, YH 10049438 general physical health deterioration AE an edema AE that has an outcome of edema where causes of edema are generalized to the whole body, can cause edema in multiple organs and peripherally DJ, SS, YH generalised oedema AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/16491771 10018092 generalized edema AE HPO: HP_0007430 SIDER: C0151603 a skin ulcer AE that results in an ulcer in the genital area usually resulting from an STD DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23064541 10018180 genital ulceration AE HPO: HP_0003249 SIDER: C0151281 an abscess AE that has an outcome of a gum-line of the teeth due to pus-filled sacs DJ, SS, YH WEB: http://www.mdguidelines.com/gingival-abscess 10052359 gingival abscess AE a digestive system AE that has an outcome of abnormally enlarged, bulging or protruding gums DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003066.htm 10018291 gingival swelling AE a kidney disorder AE that has an outcome of a decreased rate per minute at which the blood passes through the glomeruli or the filters in the kidneys DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007305.htm 10018358 glomerular filtration rate decreased AE HPO: HP_0000083 SIDER: C0853068 a digestive system AE that has an outcome of a burning or tingling sensation on the lips, tongue or entire mouth DJ, SS, YH burning tongue AE WEB: http://medical-dictionary.thefreedictionary.com/glossodynia 10018388 glossodynia AE HPO: HP_0000157 SIDER: C0017672 a glycosylated hemoglobin level abnormal AE that has an outcome of decreased levels of glycosylated hemoglobin in the blood DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23015148 10018482 glycosylated hemoglobin level decreased AE a hypothesis textual entity that represents a belief in likelihood of causal connection between process 1 and process 2. Barry Smith, Yu Lin, Oliver He belief in likelihood of causal connection between two processes an infection AE that results in a graft infection DJ, SS, YH 10056559 graft infection AE a sensorimotor painful neuropathy AE which has an outcome of distal sensory neuropathy characterized by damage to sensory and motor nerves distal sensorimotor painful neuropathy a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-positive bacteria DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/gram+stain 10018656 gram stain positive AE a nervous system AE that results in a generalized seizure that affects the entire brain DJ, SS, YH, SJ tonic seizure WEB: http://www.mayoclinic.com/health/grand-mal-seizure/DS00222 10018659 grand mal convulsion AE HPO: HP_0002197 SIDER: C0014549 a granulocyte count abnormal AE that has an outcome of compromise to the immune system where the number of neutrophil granulocytes, a type of white blood cell, is lower than the normal range of ~1700 per microliter. DJ, SS, YH, EB neutropenia AE 10018681 granulocyte count decreased AE a belief in likelihood of causal connection between two processes that represents a belief in likelihood of causal connection between medical intervention m and adverse event e. Barry Smith, Yu Lin, Oliver He belief in likelihood of causal connection between medical intervention and adverse event a hematopoietic system AE that has an outcome of a marked decrease in number of granulocytes, a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms DJ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=8817 10018687 granulocytopenia AE a psorisis AE that has an outcome of psoriasis that appears on the back and extremities of the patients DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/20860740 10018797 guttate psoriasis AE a disposition that represents the likelihood of the occurrence of an adverse event after a medical intervention. YH adverse side effect adverse effect a male reproductive system AE that has an outcome of abnormal development of large mammary glands in males resulting in breast enlargement DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/gynecomastia 10018800 gynaecomastia AE HPO: HP_0000771 SIDER: C0018418 an information content entity that represents evidence for indicating the causal association between an adverse event and a medical intervention. YH evidence bearing on adverse event causality adverse event causality evidence a vomiting AE that results in the vomiting of blood DJ, SS, YH haematemesis AE WEB: http://medical-dictionary.thefreedictionary.com/hematemesis 10018830 hematemesis AE HPO: HP_0002248 SIDER: C0018926 a digestive system AE that has an outcome of the passage of bloody stools DJ, SS, YH haematochezia AE WEB: http://medical-dictionary.thefreedictionary.com/hematochezia 10018836 hematochezia AE HPO: HP_0002573 SIDER: C0018932 a hematocrit abnormal AE with an outcome of decreased volume percentage of red blood cells in blood DJ, SS, YH, EB haematocrit decreased AE WEB: http://medical-dictionary.thefreedictionary.com/hematocrit 10018838 hematocrit decreased AE an infection AE that has an outcome of infection in a hematoma DJ, SS, YH haematoma infection AE WEB: http://medical-dictionary.thefreedictionary.com/hematoma 10051564 hematoma infection AE a hematopoietic system AE that has an outcome of toxins that destroy red blood cells, disrupt blood clotting, and/or cause organ degeneration and generalized tissue damage DJ, SS, YH haematotoxicity AE 10061188 hematotoxicity AE A conduction system disorder AE that is a condition in which ventricular contraction is not completely synchronized due to a block in conduction of an electrical impulse to the ventricles; in LBBB, right ventricular endocardial activation begins before, and is often completed before, initiation of left ventricular endocardial activation; benign LBBB is rare; preexisting LBBB in absence of clinical evidence of heart disease is rare; newly acquired LBBB has a 10-fold ↑ in mortality Clinical Generally asymptomatic, or absent or diminished 1st heart sound–HS and reversed splitting of 2nd HS EKG Lead V1–QS or rS; lead V6–late intrinsicoid deflection, monophasic R; lead I–monophasic R Management Pacemaker, if syncope or significant arrhythmias Followup Telemetry PRN. YH, SS LBBB left bundle branch block WEB: http://medical-dictionary.thefreedictionary.com/left+bundle+branch+block 10006580 bundle branch block left AE HPO: HP_0011713 SIDER: C0023211 a red blood cell profile abnormal AE that has an outcome of an abnormal count of hemoglobin, or iron-containing oxygen-transport metalloprotein in red blood cells DJ, SS, YH, EB haemoglobin abnormal AE WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin 10018879 hemoglobin level abnormal AE a vaccination that uses an influenza vaccine YH influenza vaccine administration an adverse effect that occurs after a drug administration: an appreciably harmful or unpleasant reaction resulting from an intervention related to the use of a medicinal product YH, SJ http://www.ncbi.nlm.nih.gov/pubmed/11072960 10061623 adverse drug effect a hematopoietic system AE that has an outcome of hemolytic anemia, acute kidney failure and a low platelet count DJ, SS, YH haemolytic uraemic syndrome AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307876 10018932 10019515 hemolytic uremic syndrome AE CTCAE: E10043 HPO: HP_0005575 NCIt: C75545 SIDER: C0019061 a respiratory system AE that has an outcome of expectoration of blood or blood-stained sputum from the bronchi, larynx, trachea or lungs DJ, SS, YH haemoptysis AE WEB: http://medical-dictionary.thefreedictionary.com/hemoptysis 10018964 hemoptysis AE HPO: HP_0002105 SIDER: C0019079 a nervous system AE that has an outcome of accumulation of blood within the cranial vault DJ, SS, YH haemorrhage intracranial AE WEB: http://emedicine.medscape.com/article/1163977-overview 10018985 hemorrhage intracranial AE HPO: HP_0002170 SIDER: C0151699 a female reproductive system AE that results in a 'blood cyst' where the walls of ovarian cysts are lined with blood vessels, which when rupture fill the cyst with blood. DJ, SS, YH haemorrhagic ovarian cyst AE 10060781 hemorrhagic ovarian cyst AE a surgery that removes hemorroids DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid 10059624 haemorrhoid operation an information content entity that represents the outcome of the evidences used for seeking the causal association between an adverse event and a medical intervention. YH outcome of adverse event causality evidence a digestive system AE that has an outcome of bleeding in hemorrhoids, vascular structures in the anal canal which help with stool control DJ, SS, YH haemorrhoidal haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid 10054787 10060640 hemorrhoidal hemorrhage AE CTCAE: E10767 NCIt: C78337 a digestive system AE that has an outcome of painful, swollen veins in the lower portion of the rectum or anus DJ, SS, YH haemorrhoids AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001337/ 10019022 10019611 hemorrhoids AE CTCAE: E10773 HPO: HP_0004296 NCIt: C26792 a lung disorder AE that has an outcome of a collection of blood in the space between the chest wall and the lung DJ, SS, YH haemothorax AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001183/ 10019027 hemothorax AE a hair AE that has an outcome of abnormal growth of facial or body hair DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Hair+growth 10019044 hair growth abnormal AE HPO: HP_0010720 SIDER: C0232409 an information content entity that represents a score or probability that an adverse event is likely caused (induced) by a medical intervention. YH adverse event causal association score adverse event causality assessment score adverse event causality score a hemoglobin level abnormal AE with an outcome of decrease in amount of iron-containing oxygen-transport metalloprotein in the red blood cells DJ, SS, YH, EB haemoglobin decreased AE WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin 10018884 hemoglobin level decreased AE a liver/biliary system AE that has an outcome of a chronic degenerative disease in which normal liver cells are damaged and then replaced by scar tissue DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Hepatic+cirrhosis 10019641 hepatic cirrhosis AE HPO: HP_0001394 SIDER: C0023890 a lab test abnormal AE that has an outcome of an increase in amount of hepatic enzyme in body, a liver/biliary system AE that has an outcome of elevated levels of liver enzymes, commonly ALT and AST, may indicate inflammation or damage to liver cells DJ, SS, YH elevated liver enzyme AE WEB: http://www.mayoclinic.com/health/elevated-liver-enzymes/MY00508 10060795 hepatic enzyme increased AE HPO: HP_0002910 SIDER: C0235996 a liver/biliary system AE that has an outcome of the inability of the liver to perform its normal synthetic and metabolic function DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/liver+failure 10019663 hepatic failure AE CTCAE: E11211 HPO: HP_0001399 NCIt: C26922 SIDER: C0085605 a liver/biliary system AE that results in incorrect blood flow to liver DJ, SS, YH WEB: http://archinte.jamanetwork.com/article.aspx?articleid=571358 10019680 hepatic infarction AE an adverse effect that occurs after administration of a vaccine. YH adverse vaccine effect a liver/biliary system AE with an outcome of a lesion, an abnormality in the tissue caused by disease or trauma, located in the liver DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21275132 10061998 hepatic lesion AE a liver/biliary system AE that has an outcome of death of hepatic parenchyma which may be single cell, or multicell in piecemeal, focal, periacinar, midzonal, periportal or paracentral locations DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hepatic+necrosis 10019692 hepatic necrosis AE CTCAE: E11221 HPO: HP_0002605 NCIt: C78340 SIDER: C0151798 a tumor AE that has an outcome of a malignant tumor in the liver DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23302476 10019695 hepatic neoplasm AE HPO: HP_0002896 SIDER: C0023903 Acanthosis nigricans AE is a skin AE that is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead, and other areas. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Acanthosis_nigricans 黑棘皮病 10000350 acanthosis nigricans AE a hepatitis AE that has an outcome of irritation and swelling of the liver due to infection with the heptitis B virus DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001324/ 10019731 hepatitis B AE HPO: HP_0006562 SIDER: C0019163 a hepatitis AE that has an outcome of liver inflammation due to a hepatitis viral infection DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis 10019799 hepatitis viral AE CTCAE: E11410 HPO: HP_0006562 NCIt: C35124 SIDER: C0042721 a liver/biliary system AE that has an outcome of swelling of the liver DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003275.htm 10019842 hepatomegaly AE HPO: HP_0002240 SIDER: C0019209 a liver damage AE that has an outcome of chemically driven liver damage DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hepatotoxicity 10019851 hepatotoxicity AE an influenza vaccine administration that uses Afluria YH Afluria administration an inflammation AE that has an outcome of an inflammatory infiltrate around the eccrine sweat gland DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hidradenitis 10020040 hidradenitis AE an immune system disorder AE that has an outcome of abnormal proliferation of histiocytes, a type of immune cell that eats foreign substances DJ, SS, YH histiocytosis haematophagic AE WEB: http://www.medterms.com/script/main/art.asp?articlekey=11478 10048595 histiocytosis hematophagic AE a fungal infection AE that results in an infection that occurs from breathing in the spores of the fungus Histoplasma Capsulatum DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001082.htm 10020144 histoplasmosis disseminated AE A surgery where incisions are made through a woman's abdomen and uterus to deliver her baby. YH, SS cesarean section WEB: http://medical-dictionary.thefreedictionary.com/cesarean+section 10006924 caesarean section a urinary system AE that has an outcome of distension and dilation of the renal pelvis and calyces, usually caused by the osbtruction of urine flow from the kidney DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hydronephrosis 10020524 hydronephrosis AE HPO: HP_0000126 SIDER: C0020295 a congenital abnormality AE that results in the yellowing of the skin of infants DJ, SS, YH hyperbilirubinaemia neonatal AE WEB: http://medical-dictionary.thefreedictionary.com/neonatal+jaundice 10020580 hyperbilirubinemia neonatal AE a blood calcium abnormal AE that has an outcome of an elevated calcium level in the blood, above normal range of 9-10.5 mg/dL YH, MW hypercalcaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypercalcemia 10020583 10020587 hypercalcemia AE CTCAE: E12270 HPO: HP_0003072 NCIt: C3112 SIDER: C0020437 a skin AE that results in excess perspiration DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/hyperhidrosis 10020642 hyperhidrosis AE CTCAE:E13645 HPO: HP_0000975 NCIt:C78345 SIDER: C0020458 a blood potassium abnormal AE that has a lab test outcome of an abnormally increased concentration of potassium in blood YH, MW hyperkalaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia 10020646 10020647 hyperkalemia AE CTCAE: E12282 HPO: HP_0002153 NCIt: C37968 SIDER: C0020461 toxin-induced cardiomyopathy AE cocaine-induced cardiomyopathy AE an abnormal fluid regulation AE that has an outcome of an excessive secretion of the parathyroid hormone by the parathyroid gland DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23267748 10020708 hyperparathyroidism secondary AE HPO: HP_0003106 SIDER: C0020503 a paresis AE that shows muscle weakness affecting the lower limbs. JX, YH WEB: http://www.merriam-webster.com/medical/paraparesis 下肢轻瘫 10033885 paraparesis AE a systemic hypertension AE that has an outcome of hypertension with systolic blood pressure >180 mm Hg or a diastolic pressure >120 mm, can be further classified as hypertensive urgency or hypertensive emergency depending on end-organ involvement DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/20160537 10020802 hypertensive crisis AE HPO: HP_0000875 SIDER: C0020546 a hematopoietic system AE that has an outcome of high blood levels of triglycerides, abundant fatty molecules DJ, SS, YH, MW hypertriglyceridaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypertriglyceridemia 10020869 10020870 hypertriglyceridemia AE CTCAE: E12299 HPO: HP_0002155 NCIt: C37971 SIDER: C0020557 an arthritis AE that has an outcome of uric acid building up in blood and causes joint inflammation DJ, SS, YH, MW gout AE hyperuricaemia AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/ 10020903 10020907 hyperuricemia AE CTCAE: E12305 HPO: HP_0002149 NCIt: C3961 SIDER: C0740394 a blood albumin abnormal AE that shows an abnormally low level of albumin protein in the blood. DJ, SS, YH hypoalbuminaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypoalbuminemia 10020942 10020943 hypoalbuminemia AE CTCAE: E12310 HPO: HP_0003073 NCIt: C37972 SIDER: C0239981 a blood calcium abnormal AE that has an outcome of abnormally low calcium levels, can present with convulsions, arrythmias, tetany and numbness YH, MW hypocalcaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypocalcemia 低血钙 10020947 10020949 hypocalcemia AE CTCAE: E12316 HPO: HP_0002901 NCIt: C37973 SIDER: C0020598 a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally low. DJ, SS, YH, MW WEB: https://en.wikipedia.org/wiki/Hypocapnia 10020952 hypocapnia AE UMLS CUI: C0085383 a glucose homeostasis AE that results in a abnormally diminished content of glucose in the blood DJ, SS, YH, MW hypoglycaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypoglycemia 10020993 10021005 hypoglycemia AE CTCAE: E12322 HPO: HP_0005969 NCIt: C3126 SIDER: C0020615 a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of the recording of the level of consciousness in a person after a brain injuiry. YH, SJ WEB: http://www.brainline.org/content/2010/10/what-is-the-glasgow-coma-scale.html 10069709 Clinicians use the Galscow coma scale to rate the best eye opening response, the best verbal response, and the best motor response an individual makes. The final GCS score or grade is the sum of these numbers. Glascow coma scale abnormal AE a blood magnesium abnormal AE that has an outcome of an abnormal concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors. YH, MW hypomagnesaemia AE WEB: http://medical-dictionary.thefreedictionary.com/Hypomagnesaemia 10021027 10021028 hypomagnesemia AE CTCAE: E12333 HPO: HP_0002917 NCIt: C37975 SIDER: C0151723 UMLS CUI: C0151723 a conduction system disorder AE that refers to the slow conduction of electricity through ventricular walls of the heart. SS IVCD BOOK: Taber's Cyclopedic Medical Dictionary;2005, p1134 WEB: http://connection.ebscohost.com/c/reference-entries/21232773/intraventricular-conduction-delay intraventricular conduction delay AE a gustatory system AE with an outcome of reduced food intake DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hypophagia 10063743 hypophagia AE a hematopoietic system AE that has an outcome of abnormally low phosphate levels, can present with muscle dysfunction, white cell dysfunction, pulp chambers and mental status changes DJ, SS, YH, MW hypophosphataemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypophosphatemia 10021058 10021059 hypophosphatemia AE CTCAE: E12344 HPO: HP_0008285 NCIt: C37977 SIDER: C0085682 UMLS CUI: C0085682 an endocrine system AE with the outcome of the thyroid gland does not make enough thyroid hormone DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001393/ 10021114 hypothyroidism AE CTCAE: E10334 HPO: HP_0008245 NCIt: C26800 SIDER: C0020676 a cardiovascular disorder AE that is characterized by decreased blood plasma volume DJ, SS, YH hypovolaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypovolemia 10021137 hypovolemia AE HPO: HP_0011106 SIDER: C0546884 an influenza vaccine administration that uses Flumist YH Flumist administration a cardiovascular disorder AE that has the outcome of severe blood and fluid loss that makes the heart unable to pump enough blood to the body, often leads to organ failure DJ, SS, YH hypovolaemic shock AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000167.htm 10021138 hypovolemic shock AE HPO: HP_0011106 SIDER: C0020683 a digestive system AE that has an outcome of holes in the ileum of the small intestine DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/ileum 10021305 ileal perforation AE CTCAE: E10795 NCIt: C78355 a digestive system AE that has an outcome of a partially or completely blocked bowel DJ, SS, YH intestinal obstruction AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/ 10021328 ileus AE CTCAE: E10812 HPO: HP_0002595 NCIt: C37979 SIDER: C1258215 a digestive system AE that has an outcome of intestinal blockage in the absence of an actual physical obstruction, can be caused by a malfunction in nerves and muscles in the intestine DJ, SS, YH WEB: http://www.localhealth.com/article/paralytic-ileus 10021333 ileus paralytic AE HPO: HP_0002590 SIDER: C0030446 A cardiac disorder AE that has an outcome of an abnormal enlargement of the heart YH, SS WEB: http://medical-dictionary.thefreedictionary.com/cardiomegaly added MedDRA term LB 10007632 cardiomegaly AE HPO: HP_0001640 SIDER: C0018800 a drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Immunosuppresant 10062014 immunosuppressant drug level decreased AE an immune system disorder AE that has an outcome of reduced or absent immune response DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001821/ 10062016 immunosuppression AE an injury AE that has an outcome of impairment to the process of restoring a state of soundness to any interupption in the continuity of external surfaces of the body DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/wound+healing 10021519 impaired healing AE HPO: HP_0001058 SIDER: C0151692 a pain AE that has an outcome of pain at the site of an implant DJ, SS, YH 10063782 implant site pain AE an outcome of adverse event causality evidence that has an outcome of no evidence bearing on a AE causal relation. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. no evidence bearing on an adverse event causal relation a respiratory system AE that has an outcome of increased thickness of the secretions of the bronchi DJ, SS, YH 10054761 increased viscosity of bronchial secretion AE an infection AE that results in infection by a parasite DJ, SS, YH 10021857 infection parasitic AE HPO: HP_0002719 SIDER: C0747256 an immune system disorder AE that has an outcome of increased susceptibility to infection DJ, SS, YH 10021866 infection susceptibility increased AE HPO: HP_0002719 SIDER: C0236171 an infection AE that has an outcome of an increase in severity of cystic fibrosis in the patient SZ, DJ, SS, YH 10070608 infective pulmonary exacerbation of cystic fibrosis AE a medical intervention that is used for preventive purpose YH preventive intervention a immune system AE that results in an allergic reaction to foreign protein, but can also be caused by cytokine release. SZ, DJ, SS, YH WEB: http://www.ons.org/Publications/VJC/media/ons/docs/publications/VJC/vjc-apr10cjon.pdf 10051792 10053483 infusion related reaction AE CTCAE: E11127 NCIt: C78361 an extravasation AE that has an outcome of leaking of pharmacologic or biological substance from infusion site into surrounding tissue. Symptoms include induration, erythema, swelling, burning sensation and pain SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/extravasation 10064774 infusion site extravasation AE CTCAE: E11133 NCIt: C78362 Infection AE that results in the patient gets infected at the sight of an infusion SZ, DJ, SS, YH 10054997 infusion site infection AE Rash AE that results in patient has a rash at the site of infusion SZ, DJ, SS, YH 10059830 infusion site rash AE an allergy AE that has an outcome of infusion site allergic reaction SZ, DJ, SS, YH 10054996 infusion site reaction AE a nail disorder AE that results in a nail growing into the sides of the paronychium SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/ingrowing+nail 10022013 ingrowing nail AE a skin discoloration AE that results in a discoloration of the skin at the site of injection of the drug SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/macule 10067255 injection-site macule AE Inflammation AE that results in swelling of the veins at the site of drug injection SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/phlebitis 10022090 injection-site phlebitis AE A surgery that is a procedure to remove the lens of your eye and, in most cases, replace it with an artificial lens. Cataract surgery is used to treat a cataract YH, SS cataract surgery 10063797 cataract operation an adverse event that results in the patient developing a scab at the site of drug injection SZ, DJ, SS, YH 10066210 injection-site scab AE a pain AE that results in pain at the site of instillation SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/instillation 10022459 instillation site pain AE a tremor AE that results in the patient undergoing a broad, coarse, low frequency muscle tremor SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23094990 10022520 intention tremor AE HPO: HP_0002345 SIDER: C0234376 an adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc) SZ, DJ, SS, YH 10065679 intentional drug misuse AE an incorrect dose administration AE that results in overdosing on the drug on purpose SZ, DJ, SS, YH 10022523 intentional overdose AE a lung disorder AE that has an outcome of a disease affecting the interstitium, the tissue and space around the air sacs of the lungs SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23289473 10022611 interstitial lung disease AE HPO: HP_0006530 SIDER: C0206062 a bone disorder AE that has an outcome of the protrusion of the nucleus pulposus or anulus fibrosus of the intervertebral disk, which may impinge on nerve roots SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/herniation+of+intervertebral+disk 10050296 intervertebral disc protrusion AE an ischaemia AE that has an outcome of blocked or narrowed blood vessels to the small or large intestines, can cause pain and permanent damage to the intestines SZ, DJ, SS, YH intestinal ischaemia AE 10022680 intestinal ischemia AE a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/ 10022687 intestinal obstruction AE HPO: HP_0005250 SIDER: C0021843 a gastrointestinal disorder AE that has an outcome of perforation, or complete penetration, of the wall of the intestines SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/ 10022694 intestinal perforation AE a thrombosis AE that has an outcome of thrombi in the ventricles SZ, DJ, SS, YH WEB: http://www.cvimaging.northwestern.edu/for-physicians/cardiovascular-mri/indications/intracardiac-thrombus/ 10048620 intracardiac thrombus AE a nervous system AE that has an outcome of a rise in the pressure inside the skull that can result from or cause brain injury SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000793.htm 10022773 intracranial pressure increased AE HPO: HP_0002516 SIDER: C0151740 a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal intraocular pressure in the eye SZ, DJ, SS, YH, EB 10060951 intraocular pressure test result abnormal AE a gastrointestinal disorder AE that results in part of the intestine invaginating itself into another part of the intestine SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000958.htm 10022863 According to the Vaccine Adverse Event Reporting System (VAERS), 'intussusception'; is an adverse event that was mentioned in 143 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). intussusception AE HPO: HP_0002576 MP: MP_0003294 SIDER: C0021933 an anemia AE that has an outcome of fewer healthy red blood cells because the body does not have enough iron SZ, DJ, SS, YH iron deficiency anaemia AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000584.htm 10022972 iron deficiency anemia AE HPO: HP_0001891 SIDER: C0162316 Behavior and Neurological AE that results in the patient being easily annoyed/irritated SZ, DJ, SS, YH feverish (subjective) AE 10022998 irritability AE CTCAE: E11144 HPO: HP_0000737 NCIt: C50623 SIDER: C0022107 a jaundice AE that results in an abnormal bile flow in the liver SZ, DJ, SS, YH cholestasis jaundice AE WEB: http://medical-dictionary.thefreedictionary.com/cholestatic+jaundice 10023129 jaundice cholestatic AE HPO: HP_0006575 SIDER: C0022354 a bone disorder AE that has an outcome of disease in the set of bones that hold the teeth SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/jawinjuriesanddisorders.html 10061257 jaw disorder AE a bone disorder AE that has an outcome of break in the jaw bone SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000019.htm 10023149 jaw fracture AE a thrombosis AE with an outcome of formation of a blood clot located in the internal jugular vein SZ, DJ, SS, YH 10023237 jugular vein thrombosis AE a bacterial infection AE with an outcome of invasion by Klebsiella pneumonia, a form of bacterial pneumonia SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/17307769 10061259 klebsiella infection AE HPO: HP_0002742 SIDER: C0022729 a bone disorder a that results in the knee becoming deformed SZ, DJ, SS, YH 10062061 knee deformity AE a speech disorder AE that results in the inability of a patient to speak properly SZ, DJ, SS, YH 10023615 lack of spontaneous speech AE a congetical abnormality AE that results in the patient's baby being larger than it should be at the time in their pregnancy SZ, DJ, SS, YH 10023789 large for dates baby AE an immune system disorder AE that has an outcome of an increase in the number or proportion of natural killer cells, or cytotoxic lymphocytes critical to the innate immune system SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/10761014 10023791 large granular lymphocytosis AE a gastrointestinal disorder AE that has an outcome of an ulcer in the large intestine SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Intestinal+ulcer 10023799 large intestinal ulcer AE a digestive system AE that has an outcome of perforation, or complete penetration, of the walls of the large intestine SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000235.htm 10023804 large intestine perforation AE HPO: HP_0002250 SIDER: NA an immunology and allergy investigation result abnormal that results in LE cells (neutrophil or macrophage that has phagocytized the denatured nuclear material of another cell) being detected SZ, DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/LE+cell 10024062 le cells present AE a dilatation atrial AE that results in the left atrium of the heart becoming enlarged SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096293/ 10067286 left atrial dilatation AE a cardiac ventricular disorder AE that has an outcome of inability of the left ventricle to pump blood, may lead to heart failure SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766527/ 10049694 left ventricular dysfunction AE CTCAE: E10130 NCIt: C64251 a left ventricular dysfunction AE that has an outcome of congestive heart failure marked by pulmonary congestion and edema, the left ventricle fals to contract forcefully enough to maintain normal cardiac output and peripheral perfusion SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/left+ventricular+failure 10024119 left ventricular failure AE HPO: HP_0001635 SIDER: C0023212 a left ventricular dysfunction disorder AE that has an outcome of the thickening of the myocardium of the left ventricle of the heart SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/18030317 10049773 left ventricular hypertrophy AE a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by return of symptoms after remission SZ, DJ, SS, YH leukaemia recurrent AE WEB: http://www.yourcancertoday.com/Cancers/Leukemia-Acute-Myeloid-Adult/53 10062489 leukemia recurrent AE a nervous system AE that has an outcome of cancerous white blood cells infiltrating the brain SZ, DJ, SS, YH leukaemic infiltration brain AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/1454121 10064987 leukemic infiltration brain AE Immune system disorder AE that results in an increase in white blood cell count as a result of stress or infection SZ, DJ, SS, YH leukaemoid reaction AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000575.htm 10024328 leukemoid reaction AE HPO: HP_0001909 SIDER: C0023501 an outcome of adverse event causality evidence that has an outcome of evidence is inadequate to accept or reject an adverse event causal relation YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. evidence inadequate to accept or reject an adverse event causal relation an vasculitis AE that has an outcome of fragmented cells, and debris in the blood vessels. May develop skin lesions, accompanied by arthralgia and fever SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/leukocytoclastic+vasculitis 白细胞破碎性血管炎 10024377 leukocytoclastic vasculitis AE HPO: HP_0011944 SIDER: C2973529 Urinary system AE that results in white blood cells in the urine SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/leukocyturia 10050791 leukocyturia AE an encephalopathy AE that has an outcome of brain white matter disease SZ, DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/leukoencephalopathy 10024382 leukoencephalopathy AE CTCAE:E12712 HPO: HP_0002352 NCIt:C27059 SIDER: C0270612 a hematopoietic system AE that has an outcome of a lower than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154209/ 10024384 leukopenia AE HPO: HP_0001882 SIDER: C0023530 a psychiatric disorder AE that results in a disorder in the patient's desire for sexual interaction SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695750/ 10061221 libido disorder AE a skin AE that has an outcome of an itchy rash on the skin or in the mouth SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001870/ 10024429 lichen planus AE a skin erosion AE that results in the deterioration of the lip skin SZ, DJ, SS, YH 10051992 lip erosion AE a digestive system AE that has an outcome of an excess of lipase, a pancreatic enzyme, may indicate a problem related to pancreas SZ, DJ, SS, YH hyperlipasemia AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/15653991 10024574 lipase increased AE CTCAE: E12185 NCIt: C78435 A medical intervention that is a tube going into a vein in your chest. It will help carry nutrients and medicine into your body. It will also be used to take blood when you need to have blood tests. YH, SS WEB: http://www.nlm.nih.gov/medlineplus/ency/patientinstructions/000157.htm 10053377 central venous catheterisation Liver/biliary system AE that results in the disease of the liver SZ, DJ, SS, YH liver disorder WEB: http://www.nlm.nih.gov/medlineplus/liverdiseases.html 10024670 liver AE HPO: HP_0006706 SIDER: C0023895 a localized edema AE that shows the outcome of swelling. SZ, DJ, SS, YH 10024770 local swelling AE an infection AE located in a certain area SZ, DJ, SS, YH localised infection AE 10024774 localized infection AE HPO: HP_0002719 SIDER: C0016397 Abnormal fluid regulation AE that results in a collection of fluid in the intraabdominal area SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/intra-abdominal 10066768 localised intraabdominal fluid collection AE an edema AE occuring in a specific region SZ, DJ, SS, YH localised edema AE localised oedema AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115975/ 10048961 10062466 localized edema AE CTCAE: E11148 HPO: HP_0000969 NCIt: C78437 SIDER: C0013609 a movement disorder AE that has an outcome of loss of the sense of the relative position of neighbouring parts of the body and strength of effort being employed in movement SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/8294975 10057332 loss of proprioception AE a gastrointestinal hemorrhage AE that has an outcome of bleeding in the lower gastrointestinal tract SZ, DJ, SS, YH lower gastrointestinal haemorrhage AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003133.htm 10050953 lower gastrointestinal hemorrhage AE HPO: HP_0002239 SIDER: C0024050 an infection AE that has an outcome of infection in the lower respiratory tract, includes pneumonea as well as lung abscess and acute bronchitis SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/books/NBK8142/ 10024968 lower respiratory tract infection AE HPO: HP_0002783 SIDER: C0149725 a lung disorder AE that has an outcome of liquid filling a region of lung tissue, marked by induration of a normally aerated lung SZ, DJ, SS, YH pulmonary consolidation AE WEB: http://medical-dictionary.thefreedictionary.com/consolidation 10025080 lung consolidation AE an infection AE that has an outcome of infection in the lungs SZ, DJ, SS, YH WEB: http://www.livestrong.com/lung-infection/ 10061229 lung infection AE CTCAE: E11444 HPO: HP_0002783 NCIt: C26873 SIDER: C0876973 a lung disorder AE that has an outcome of an abnormal presence of granulomas, fluid, inflammatory exudates or cells in the lung tissue SZ, DJ, SS, YH WEB: http://www.blurtit.com/q840550.html 10025102 lung infiltration AE HPO: HP_0005828 SIDER: C0235896 a tumor AE that has an outcome of a malignant tumor in the lung SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Lung+neoplasm 10062042 lung neoplasm AE HPO: HP_0100526 SIDER: C0024121 an immune system disorder AE that has an outcome of lymphadenopathy, which is a term meaning "disease of the lymph nodes" . It is generally a disease or inflammation of the lymph nodes, could be due to infection, auto-immune disease or malignancy SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/lymphadenopathy 10025197 lymphadenopathy AE HPO: HP_0002716 SIDER: C0497156 an inflammation AE occuring in the lymph vessels secondary to a malignancy SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/8930034 10053132 lymphangiosis carcinomatosa AE a lymphocyte count abnormal AE that has an outcome of a decreased amount of lymphocytes in the blood, a type of white blood cell in the immune system SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm 10025256 lymphocyte count decreased AE CTCAE: E12190 NCIt: C26823 a lymphocyte percentage abnormal AE that results in an increase in the levels of lymphocytes in the blood SZ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm 10052232 lymphocyte percentage increased AE an immune system disorder AE that results in lymphocytes being infiltrated by harmful substances SZ, SS, YH WEB: http://emedicine.medscape.com/article/1098654-overview 10062049 lymphocytic infiltration AE an immune system disorder AE that has an outcome of an increase in the number or proportion of lymphocytes in the blood SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/lymphocytosis 10025280 lymphocytosis AE HPO: HP_0012141 SIDER: C0024282 an edema AE that has an outcome of localized fluid retention and tissue swelling caused by a compromised lymphatic system SZ, SS, YH WEB: Primary Source: http://emedicine.medscape.com/article/1087313-overview Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23073712 10025282 lymphoedema AE HPO: HP_0001004 SIDER: C0024236 a hematopoietic system AE that has an outcome of reduction in the number of lymphocytes in the blood SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/lymphopenia 10025327 lymphopenia AE HPO: HP_0001888 SIDER: C0024312 a eye disorder AE that has an outcome of cell death in the macula of the eye, destroying central vision SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/maculardegeneration.html 10025409 macular degeneration AE HPO: HP_0007673 SIDER: C0024437 a male reproductive system disorder AE that results in the inability of the male to achieve an orgasm despite lengthy sexual contact SZ, SS, YH WEB: http://www.minddisorders.com/Kau-Nu/Male-orgasmic-disorder.html#b 10025513 male orgasmic disorder AE a tumor AE that has an outcome of growth or proliferation of an abnormal mass of tissue SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19824467 10061309 malignant neoplasm progression AE an respiratory system AE that has an outcome of abnormal amount of fluid collecting between the layers of tissue lining the outside of the lung and wall of chest cavity, caused by cancer SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/11529302 10026673 malignant pleural effusion AE A surgery that is a surgical procedure to remove all or part of your colon. YH, SS WEB: http://www.mayoclinic.com/health/colectomy/MY00141/METHOD=print 10061778 colectomy a surgery that is performed to change the size of breasts SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/mammoplasty 10068647 mammoplasty an arterial disorder AE that resuts in arteries that supply blood to heart muscle become hardened and narrowed. YH, SS coronary artery disese AE WEB: http://www.nlm.nih.gov/medlineplus/coronaryarterydisease.html 10011078 10011082 coronary artery disorder AE a hematopoietic system AE that has an outcome of bone marrow that contains an excess of blood cells SZ, SS, YH WEB: http://www.mayoclinic.com/health/aplastic-anemia/DS00322/DSECTION=causes 10026851 marrow hyperplasia AE a perinatal AE that results in the drugs being taken by the mother affecting unborn fetus in mother SZ, SS, YH maternal drugs affecting foetus AE 10026923 maternal drugs affecting fetus AE an adverse event that results in a problem in the mediastinum of the patient (undelineated group of structures in the thorax surrounded by loose connective tissue) SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Mediastinal+diseases 10061280 mediastinal disorder AE HPO: HP_0000765 SIDER: C0025061 a digestive system AE that has an outcome of abnormal dilation of the colon, often accompanied by paralysis of the peristaltic movements of the bowel SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/megacolon 10027110 megacolon AE HPO: HP_0002251 SIDER: C0025160 Abnormal defecation AE that results in black feces associated with gastrointestinal hemorrhage SZ, SS, YH melaena AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003130.htm 10027141 melena AE HPO: HP_0002249 SIDER: C0025222 Behavior and Neurological AE that results in the loss of memory SZ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/impaired+memory 10027175 memory impairment AE CTCAE:E12718 HPO: HP_0002354 NCIt:C78444 SIDER: C0233794 a brain inflammation AE that results in the layers lining the brain becoming inflamed, not due to pygonenic bacteria SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/aseptic+meningitis 10027201 meningitis aseptic AE HPO: HP_0001287 SIDER: C0025290 Hematuria AE that results in excessive uterine bleeding occurs irregularly and more frequently than normal SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/menometrorrhagia 10027295 menometrorrhagia AE HPO: HP_0100608 SIDER: C0232943 Female Reproductive System AE that results in abnormally heavy and prolonged menstrual period SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0014910/ 10027313 menorrhagia AE CTCAE:E13132 HPO: HP_0000132 NCIt:C26829 SIDER: C0025323 a psychiatric disorder AE that has an outcome of changes in mental status SZ, SS, YH, Izabela Birsanescu WEB: http://www.medicinenet.com/altered_mental_status/symptoms.htm 10048294 A mental status change does not have to be a disorder or even an adverse event. It can be a good change, from a disorder status to a normal recovered status. mental status changes AE a metabolism, endocrine, and exocrine system AE that has an outcome of abnormal chemical reactions in the body that disrupts a metabolic process SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/metabolicdisorders.html 10058097 metabolic disorder AE A cardiac disorder AE that has an outcome of enlargement of the heart YH, SS atrial dilatation, atrial enlargement 10013002 dilatation atrial AE an abdominal AE that shows the spreading of the cancer cells to the abdominal cavity of the patient SZ, SS, YH WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/19373966 10027450 metastasis to abdominal cavity AE a tumor AE that has an outcome of cancerous cells spreading to the bone from elsewhere SZ, SS, YH 10027452 metastasis to bone AE a tumor AE that results in cancerous cells spreading from a primary tumor to the central nervous system SZ, SS, YH WEB: http://theoncologist.alphamedpress.org/content/8/5/398.long, http://www.ncbi.nlm.nih.gov/pubmed/19373966 10059282 metastasis to central nervous system AE a tumor AE that results in cancerous cells spreading to the liver organ SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000277.htm 10027457 metastasis to liver AE a tumor AE that results in cancerous cells spreading to the lung SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000097.htm 10027458 metastasis to lung AE a tumor AE that has an outcome cancerous cells spreaing from primary tumor to the thin layers of tissue that protect the brain and spinal cord, may experience increased intracranial pressure SZ, SS, YH meningeal metastasis AE WEB: 1. http://theoncologist.alphamedpress.org/content/1/1/56.full 2. http://www.cancer.gov/dictionary?cdrid=45782 10051696 metastasis to meninges AE a tumor AE that results in cancerous cells spreading from primary tumor to the lining of the abdominal cavity or the coelom. SZ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/peritoneum Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed?term=metastasis%20to%20peritoneum%20%5BTI%5D 10051676 metastasis to peritoneum AE a tumor AE that results in a disease spreading to the pleural cavity due to cancerous activities SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/pleuraldisorders.html 10027463 metastasis to pleura AE an outcome of adverse event causality evidence that has an outcome of evidence favors rejection of an adverse event causal relation YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. evidence favoring rejection of an adverse event causal relation a tumor AE that results in cancerous cells spreading to the spine SZ, SS, YH WEB: http://emedicine.medscape.com/article/1157987-overview 10027468 metastasis to spine AE a tumor AE with an outcome of spreading of disease from one organ to another non-adjacent organ or part SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm 10062194 metastasis AE a tumor AE with an outcome of spreading of cancerous cells from abnormal mass of tissue SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/20121607 10061289 metastatic neoplasm AE Urinary System AE that is characterized by uterine bleeding at irregular intervals SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/metrorrhagia 10027514 metrorrhagia AE HPO: HP_0100608 SIDER: C0025874 Cardiovascular disorder AE that results in a fragmentation of red blood cells resulting from the narrowing of small blood vessels SZ, SS, YH microangiopathic haemolytic anaemia AE WEB: http://medical-dictionary.thefreedictionary.com/microangiopathic+hemolytic+anemia 10027527 microangiopathic hemolytic anemia AE HPO: HP_0001937 SIDER: C0221021 a cardiac valve disease AE that is characterized by the inability of the heart's mitral valve to close tightly, allowing blood to flow backward in the heart SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Mitral+Valve+Insufficiency 10027727 mitral valve incompetence AE HPO: HP_0001653 SIDER: C0026266 a digestive system AE that has an outcome of bleeding from blood vessels located in the mouth SZ, SS, YH mouth haemorrhage AE WEB: http://sideeffects.embl.de/se/C0029163/ 10028024 mouth hemorrhage AE HPO: HP_0000167 SIDER: C0029163 a digestive system AE that has an outcome of sores or open lesions in the mouth SZ, SS, YH aphthous stomatitis AE canker sore AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001448.htm 10028034 mouth ulceration AE HPO: HP_0000155 SIDER: C0149745 Multiple Sclerosis AE that is characterized by a relapse of Multiple Sclerosis SZ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001747/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22980532 10048393 multiple sclerosis relapse AE a muscle contraction AE that has an outcome of painful sensations, associated with muscle fatigue and low sodium/potassium SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/musclecramps.html 10028294 muscle cramp AE a muscle enzyme level abnormal AE that results in an increased level of muscle enzyme SZ, SS, YH 10057945 muscle enzyme level increased AE a muscle AE that results in the musculoskeletal system being weakened at locomotion is hampered SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002172/ 10028356 muscular dystrophy AE a pain AE located in musculoskeletal structures of the chest wall, atypical or noncardiac chest pain SZ, SS, YH WEB: http://www.uptodate.com/contents/major-causes-of-musculoskeletal-chest-pain?source=see_link 10050819 musculoskeletal chest pain AE HPO: HP_0006649 SIDER: C0476280 Bacterial infection AE that results in the patient being infected with the Mycoplasma bacteria SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/15142464 10061300 mycoplasma infection AE an outcome of adverse event causality evidence that has an outcome of evidence favors acceptance of an adverse event causal relation YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. evidence favoring acceptance of an adverse event causal relation a hematopoietic system AE that has an outcome of ineffective production of the myeloid class of blood cells SZ, SS, YH, MW WEB: http://www.nlm.nih.gov/medlineplus/myelodysplasticsyndromes.html 10028533 myelodysplastic syndrome AE CTCAE:E12552 HPO: HP_0006730 NCIt:C3247 SIDER: C0026986 a hematopoietic system AE that has an outcome of bone marrow being replaced by scar tissue SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001558/ 10028537 myelofibrosis AE HPO: HP_0011974 SIDER: C0026987 a cardiac disorder AE that has an outcome of an imbalance between myocardial oxygen supply and demand SZ, SS, YH myocardial ischaemia AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768241/ 10028600 myocardial ischemia AE HPO: HP_0001637 SIDER: C0151744 an inflammation AE that has an outcome of inflammation of the heart muscle SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001204/ 10028606 myocarditis AE CTCAE: E10157 NCIt: C34831 a bone disorder AE, most commonly fungal infection, that is characterized by discoloration, painful swelling, pits, lesions and brown bands SZ, SS, YH WEB: http://www.umm.edu/altmed/articles/nail-disorders-000116.htm 10028694 nail disorder AE HPO: HP_0001597 SIDER: C0027339 a nail AE around the nail area, tends to be fungal SZ, SS, YH WEB: http://www.emedicinehealth.com/paronychia_nail_infection/article_em.htm 10061304 nail infection AE HPO: HP_0008396 SIDER: C0343026 Cell death AE that results in necrosis occurring due to a local deprivation of blood SZ, SS, YH necrosis ischaemic AE WEB: http://medical-dictionary.thefreedictionary.com/ischemic+necrosis 10028862 necrosis ischemic AE a progressive tumor AE that has an outcome of an abnormal mass of cells that metastasizes SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/malignant+neoplasm 10028997 neoplasm malignant AE HPO: HP_0002664 SIDER: C0006826 an tumor AE that has an outcome of growth of the neoplasm, an abnormal mass of tissue in the body SZ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/neoplasm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23263846 10061309 neoplasm progression AE a tumor AE that has an outcome of microscopic cells of the original neoplasm escaping therapeutic intervention and later becoming clinically visible at the original site SZ, SS, YH 10061864 neoplasm recurrence AE Kidney disorder AE that results in an increased amount of calcium deposits in the renal parenchyma SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001522/ 10029146 nephrocalcinosis AE HPO: HP_0000121 SIDER: C0027709 a kidney disorder AE that has an outcome of a group of symptoms that include protein in the urine, low blood protein levels, high cholesterol levels, high triglyceride levels and swelling SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001520/ 10029164 nephrotic syndrome AE HPO: HP_0000100 SIDER: C0027726 a neuropathy AE that has an outcome of direct pressure on a single nerve, can cause pain, tingling and muscle weakness SZ, SS, YH WEB: http://nerve.wustl.edu/nd_compression.php 10029174 nerve compression AE Nervous System AE that results in pressure on a root nerve SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/6719259 10061866 nerve root compression AE Nervous system AE that results in a lesion occurring on a nerve root SZ, SS, YH 10029188 nerve root lesion AE A nervous system AE that has an outcome of inability of maintaining neurological functions. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/decompensation 10068357 neurological decompensation AE Tumor AE that results in a tumor growing on nerve tissue SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/neuroma 10029308 neuroma AE HPO: HP_0009588 SIDER: C0027858 a nervous system AE that alters the normal activity of the nervous system due to exposure to neurotoxins (which can be natural or artificial toxic substances), and causes damage to nervous tissue SZ, SS, YH, QL toxic neuropathy AE WEB: http://en.wikipedia.org/wiki/Neurotoxicity 10029350 10067722 neurotoxicity AE an immunolgy and allergy investigation result abnormal AE that is chracterized by neutralising antibodies detected in the blood SZ, SS, YH, EB neutralising antibodies positive AE WEB: http://medical-dictionary.thefreedictionary.com/neutralizing+antibody 10064980 neutralizing antibodies positive AE a neutropenia AE that compromises the immune system where the number of neutrophil granulocytes, a type of white blood cell, is abnormally low. A neutropenia makes body vulnerable to bacterial and fungal infections. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/neutropenia 10029354 neutropenia AE HPO: HP_0001875 SIDER: C0027947 a neutropenia AE that results in an abnormal number of neutrophils in a newborn infant SZ, SS, YH WEB: http://www.thefreedictionary.com/neonatal, http://medical-dictionary.thefreedictionary.com/neonatal+neutropenia,+alloimmune 10029358 neutropenia neonatal AE a gastrointestinal Inflammation AE that results in the cecum, part of the large intestine, being inflamed SZ, SS, YH WEB: http://emedicine.medscape.com/article/183791-overview 10062959 neutropenic colitis AE HPO: HP_0002583 SIDER: C0400823 a sepsis AE caused by neutropenia or an abnormally low neutrophil count SZ, SS, YH WEB: http://guidance.nice.org.uk/CG151 10049151 neutropenic sepsis AE a white blood cell profile abnormal AE that results in an abnormal number of neutrophil granulocytes, a type of white blood cell (outside the normal range of ~1700 per microliter) SZ, SS, YH, EB WEB: http://www.medterms.com/script/main/art.asp?articlekey=20030 10061313 neutrophil count abnormal AE a neutrophil count abnormal AE that has an outcome of decreased neutrophil count SZ, SS, YH, EB neutropenia AE WEB: http://www.mayoclinic.com/health/neutropenia/MY00110 10029366 neutrophil count decreased AE CTCAE: E12198 HPO: HP_0011991 NCIt: C80520 SIDER: NA a neutrophil percentage abnormal AE that has an outcome of increase in percentage of neutrophils, a type of white blood cell SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/neutrophil 10052224 neutrophil percentage increased AE a hyperplasia AE that has an outcome of liver/biliary system cell overproduction, associated with portal hypertension SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070012/ 10051081 nodular regenerative hyperplasia AE a lung disorder AE that has an outcome of adenocarcinomas in an outer area of the lung, squamous cell carcinomas in the center of the lung or large cell carcinomas in any part of the lung SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004462/ 10061873 non-small cell lung cancer AE a lung disorder AE that results in the patient suffering from lung cancer at state IV SZ, SS, YH 10029522 non-small cell lung cancer stage iv AE an anemia AE that has an outcome of insufficient numbers of red blood cells despite a normal concentration of hemoglobin in the cells SZ, SS, YH normochromic normocytic anaemia AE WEB: http://medical-dictionary.thefreedictionary.com/normocytic+normochromic+anemia 10029783 normochromic normocytic anemia AE HPO: HP_0001897 SIDER: C0271899 a surgery that aims to control obesity SZ, SS, YH 10059610 obesity surgery a respiratory system AE that has an outcome of chronic bronchitis or emphysema which causes the airways to narrow over time SZ, SS, YH WEB: http://www.medicinenet.com/chronic_obstructive_pulmonary_disease_copd/article.htm 10061877 obstructive airways disorder AE HPO: HP_0006536 SIDER: C0600260 a gastrointestinal investigation result abnormal AE that results in blood that is present in amounts too small to be seen and can be detected only by chemical analysis or microscopic examination SZ, SS, YH, EB WEB: http://dictionary.reference.com/browse/occult+blood WEB: http://medical-dictionary.thefreedictionary.com/occult+blood\ 10061878 occult blood AE a gustatory system AE that has an outcome of painful swallowing in the mouth or esophagus. Can lead to weight loss. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/odynophagia 10030094 odynophagia AE a pain AE located in the esophagus SZ, SS, YH oesophageal pain AE WEB: http://medical-dictionary.thefreedictionary.com/oesophageal 10015388 10030180 esophageal pain AE CTCAE: E10661 HPO: HP_0010833 NCIt: C78280 SIDER: C0221727 an esophagus AE that results in a narrowing in the esophagus caused by buildup of scar tissue or by a congenital defect SZ, SS, YH oesophageal stenosis AE WEB: http://esophagealstenosis.org/ 10015448 10030194 esophageal stenosis AE CTCAE: E10670 HPO: HP_0010450 NCIt: C34595 SIDER: C0014866 an esophagus AE located in the esophagus, can present with heartburn, and nausea SZ, SS, YH oesophagitis AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/ 10015461 10030216 esophagitis AE CTCAE: E10687 HPO: HP_0100633 NCIt: C9224 SIDER: C0014868 a reproductive system AE that has an outcome of insufficient placenta, the baby may get less oxygen and nutrients SZ, SS, YH placental dysfunction AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002455/ 10030289 oligohydramnios AE HPO: HP_0001562 SIDER: C0079924 a nail disorder AE that has an outcome of pain in the fingernails or toenails SZ, SS, YH WEB: http://dictionary.reference.com/browse/onychalgia 10064251 onychalgia AE a nail disorder AE that results in the breaking of the fingernails or toenails SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/onychoclasis 10048886 onychoclasis AE HPO: HP_0001808 SIDER: C0546956 a nail disorder AE that results in the nail separating from the nail bed starting at distal or lateral attachment SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/16422468 10030337 onycholysis AE HPO: HP_0008400 SIDER: C0085661 an outcome of adverse event causality evidence that has an outcome of evidence establishes an adverse event causal relation YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 33. evidence establishing an adverse event causal relation a nail disorder AE that results in nails spontaneously shedding starting from the proximal end SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/onychomadesis 10049274 onychomadesis AE Eye disorder AE that results in chronic glaucoma progressing slowly SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002587/ 10030348 open angle glaucoma AE HPO: HP_0000501 SIDER: C0017612 a toxicology drug screen result abnormal AE that results in the patient testing positive for opiates SZ, SS, YH, EB 10063232 opiates positive AE a digestive system AE that has an outcome of a fungal infection located in the mouth caused by the candida fungus SZ, SS, YH thrush AE WEB: http://www.medicinenet.com/thrush/article.htm 10030963 oral candidiasis AE HPO: HP_0009098 SIDER: C0006849 a digestive system AE that has an outcome of fistula, or an abnormal connection between two epithelium-lined organs or vessels, located in the oral cavity SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/fistula 10065720 oral cavity fistula AE CTCAE: E10888 NCIt: C78506 a digestive system AE that has an outcome of a viral infection located in the mouth caused by herpes simplex virus, causes painful sores SZ, SS, YH WEB: http://www.emedicinehealth.com/oral_herpes/article_em.htm 10067152 oral herpes AE a gustatory system AE that has an outcome of a decreased amount of substance in food or drinking water ingested SZ, SS, YH oral intake reduced AE Digestive System AE that results in oral lesions SZ, SS, YH 10064594 oral mucosa erosion AE an erythema AE that results in redness of the oral mucosa area SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/17767983 10067418 oral mucosal erythema AE a pain AE located in the oral cavity, pertaining to the mouth SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/oral 10031009 oral pain AE CTCAE: E10904 HPO: HP_0010833 NCIt: C78509 SIDER: C0221776 a digestive system AE that has an outcome of disease in the soft tissue of the mouth or systemic diseases involving the mouth SZ, SS, YH WEB: http://clinicaltrials.gov/show/NCT00001601 10031015 oral soft tissue disorder AE a surgery that treats injuries and defects involving both the functional and esthetic aspects of the hard/soft tissue of the head, mouth, teeth, gums, jaws, and neck SZ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/oral+surgery Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22530364 10051059 oral surgery an edema that results in swelling around the eyes SZ, SS, YH orbital oedema AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/7654583 10031051 orbital edema AE HPO: HP_0100539 SIDER: C0424813 a pneumonia AE that results in the healing process being characterized by organization and cicatrizaion of the exudate rather than resolution SZ, SS, YH organising pneumonia AE WEB: Primary Source: http://thorax.bmj.com/content/55/4/318.full Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745738/ 10067472 organizing pneumonia AE HPO: HP_0002090 SIDER: C0264383 Digestive System AE that is characterized by fungus (mainly Candida albicans, but can be other Candida species - C.glabrata, C. tropicalis, C. krusei) in throat or mouth (Thrush) SZ, SS, YH WEB: http://www.cdc.gov/fungal/candidiasis/thrush/ 10050346 oropharyngeal candidiasis AE HPO: HP_0009098 SIDER: C0919659 a digestive system AE that has an outcome of muscle spasm in the oropharynx area SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Oropharyngeal+airway 10031111 oropharyngeal spasm AE HPO: HP_0003739 SIDER: C0234952 a bone disorder AE that has an outcome of bacterial infection in the bone SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001473/ 10031252 osteomyelitis AE HPO: HP_0007626 SIDER: C0029443 a bone disorder AE that has an outcome of chronic infection of the bone or bone marrow SZ, SS, YH WEB: Primary Source: http://www.posna.org/education/StudyGuide/chronicOsteomyelitis.asp Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/20471296 10031256 osteomyelitis chronic AE a data item that represents the ratio of the rate of occurence of the adverse event in persons having the medical intervention (e.g., vaccination) to the rate in otherwise comparable persons without the medical intervention. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20-21. adverse event relative risk a bone disorder AE that has an outcome of bone death due to the loss of blood supply, leading to pain and arthritis SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/osteonecrosis.html 10031264 osteonecrosis AE HPO: HP_0010885 SIDER: C0029445 a bone disorder AE that has an outcome of disease that affects the maxilla and the mandible, characterized through exposure of the bone through lesions in the gingiva that do not heal SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/16702591 10064658 osteonecrosis of jaw AE HPO: HP_0010885 SIDER: C1401381 a bone disorder AE that has an outcome of necrosis or death of bone as a result of exposure to radiation SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/osteoradionecrosis 10067352 osteoradionecrosis AE a bone disorder AE that has an outcome of elevation in bone density SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/osteosclerosis 10031298 osteosclerosis AE HPO: HP_0011001 SIDER: C0029464 a female reproductive system AE that has an outcome of cancer that starts in the ovaries, female reproductive organs that produce eggs SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001891/ 10033128 ovarian cancer AE HPO: HP_0100615 SIDER: C1140680 Female reproductive system AE that results in an enlargement of the patient's ovaries SZ, SS, YH 10033157 ovarian enlargement AE a female reproductive system AE that has an outcome of an abnormal mass appearing in the patient's ovaries SZ, SS, YH 10058823 ovarian mass AE Incorrect dose administration AE that results in the ingestion or application of a drug in greater quantities than recommended SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007287.htm 10033295 overdose AE an oxygen saturation abnormal AE that has an outcome of a decreased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen SZ, SS, YH, EB WEB: Primary Source: http://www.mayoclinic.com/health/hypoxemia/MY00219\ Secondary Source: http://medical-dictionary.thefreedictionary.com/oxygen+saturation 10033318 oxygen saturation decreased AE a pain AE that has an outcome of pain in the set of bones that hold the teeth SZ, SS, YH 10033433 pain in jaw AE HPO: HP_0200023 SIDER: C0236000 a pain AE located in the skin SZ, SS, YH, MW 10033474 pain of skin AE CTCAE:E13668 HPO: HP_0010833 NCIt:C78516 SIDER: C0241136 a erythema AE that is characterized by the reddening of the palms at the thenar and hypothenar eminences SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/18039017 10033551 palmar erythema AE HPO: HP_0007548 SIDER: C0014745 a skin AE generally caused by chemotherapy that is characterized by the palms and soles becoming red, swollen, numb and the skin peeling. YH: MedDRA: 10033553 is for "palmar-plantar erythrodysaesthesia syndrome"; MedDRA: 10054524 is for "palmar-plantar erythrodysesthesia syndrome". SZ, SS, YH, MW Hand Food Syndrome AE palmar-plantar erythrodysaesthesia syndrome AE WEB: http://news.cancerconnect.com/hand-foot-syndrome-palmar-plantar-erythrodysesthesia/ palmar-plantar erythrodysesthesia syndrome AE CTCAE: E13672 NCIt: C27177 UMLS CUI: C0549410 Tumor AE that results in an undifferentiated growth in the patient's pancreas SZ, SS, YH WEB: Primary Source: http://stanfordhospital.org/digestivehealth/pancreas/conditions/pancreatic-cysts-symptoms-diagnosis.html Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22855657 10049082 pancreatic mass AE a pancreatitis AE that has an outcome of sudden inflammation of the pancreas SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000287.htm 10033647 pancreatitis acute AE HPO: HP_0001735 SIDER: C0001339 a pancreatitis AE that results in pancreatitis reoccurring in the patient SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002129/ 10033657 pancreatitis relapsing AE Hematopoietic System AE that results in a reduction in the amount of red and white blood cells and platelets in blood SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/pancytopenia 10033661 pancytopenia AE HPO: HP_0001876 SIDER: C0030312 an edema AE that has an outcome of optic disc swelling that is caused by increased intracranial pressure SZ, SS, YH papilledema AE WEB: http://medical-dictionary.thefreedictionary.com/Papilloedema 10033703 10033712 papilloedema AE CTCAE: E10411 HPO: HP_0001085 NCIt: C3307 SIDER: C0030353 a data item that represents the incidence of the adverse event among recipients of a medical intervention (e.g., vaccinatoin) minus the incidence of the adverse event among otherwise similar nonrecipients. The AE risk difference depends on both the background incidence of the adverse event (i.e., among nonrecipients) and the relative risk of its occurence in medical intervention recipients versus nonrecipients. Even when the AE rlative risk is high, the AE risk difference will be low if the event is extremely rare. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 27. adverse event risk difference Tumor AE that results in a benign tumor in the parathyroid region SZ, SS, YH parathyroid tumour benign AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001188.htm 10033964 parathyroid tumor benign AE a skin infection AE thar occurs around the fingernails and toenailsnail. Bacteria or a type of yeast called Candida cause this infection. Bacteria and yeast can even combine into one infection. SZ, SS, YH, MW nail infection AE WEB: http://www.healthline.com/health/paronychia WEB: https://en.wikipedia.org/wiki/Paronychia 10034016 paronychia AE HPO: HP_0001818 SIDER: C0030578 a bone disorder AE that has an outcome of a broken bone caused by disease leading to weakenss of the bone, commonly osteoporosis SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/pathological+fracture 10034156 pathological fracture AE HPO: HP_0005744 SIDER: C0016663 a cardiac disorder AE that has an outcome of abnormal accumulation of fluid in the pericardial cavity SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110902/ 10034474 pericardial effusion AE CTCAE: E10172 HPO: HP_0001698 NCIt: C3319 SIDER: C0031039 a pain AE that results in soreness around the vaginal opening after giving birth SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmed/20002420 10061339 perineal pain AE CTCAE:E13175 NCIt:C78529 a digestive system AE that has an outcome of inflammation and infection that destroys the tissues that support the teeth, including the gums, the periodontal ligaments and the tooth sockets SZ, SS, YH gingivitis AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002051/ 牙龈炎 10034536 periodontal disease AE CTCAE: E10935 HPO: HP_0000704 NCIt: C63743 SIDER: C0031090 a bone disorder AE that has an outcome of inflammation and infection of the ligaments and bones that support the teeth SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002054/ 10034539 periodontitis AE HPO: HP_0000704 SIDER: C0031099 an ischaemia AE that has an outcome of restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism YH: MedDRA: 10034576 is for "peripheral ischaemia"; MedDRA: 10034578 is for "peripheral ischemia". SZ, SS, YH peripheral ischaemia AE WEB: Primary Source: http://www.medterms.com/script/main/art.asp?articlekey=4052 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/6430442 外周缺血 10034576 10034578 peripheral ischemia AE CTCAE:E13810 HPO: HP_0002597 NCIt: C78535 SIDER: C0235490 a motor neuropathy AE that results in damage to the nerves outside of the brain and spinal cord SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001619/ 10034580 peripheral motor neuropathy AE CTCAE:E12762 HPO: HP_0007178 NCIt:C3500 SIDER: C0235025 a peripheral sensory neuropathy AE that results in the patient losing the ability to move or feel. SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000750.htm 10056673 Neuropathy can affect nerves that provide feeling (sensory neuropathy) or cause movement (motor neuropathy). It can also affect both, in which case it is called a sensorimotor neuropathy. peripheral sensorimotor neuropathy AE a sensory neuropathy AE that has an outcome of damaged nerves outside the brain and spinal cord SZ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/Peripheral+sensory+neuropathy 10034620 peripheral sensory neuropathy AE CTCAE:E12768 HPO: HP_0000763 NCIt:C3501 SIDER: C0151313 an abscess AE that results in a collection of infected material around the tonsils SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001981/ 10034686 peritonsillar abscess AE HPO: HP_0001739 SIDER: C0031157 Respiratory system AE characterized by the whooping cough SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002528/ 10034738 pertussis AE a hemorrhage AE that has an outcome of tiny pinpoint red dots that form due to broken blood vessels under the skin SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm 10034754 petechiae AE HPO: HP_0000967 MP: MP_0008816 SIDER: C0031256 Inflammation AE that results in an inflammation of the pharyngeal region SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/11172144 10065716 pharyngeal inflammation AE a phlebitis that is characterized by blood clots that occur in different locations SZ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Thrombophlebitis Secondary Source: http://emedicine.medscape.com/article/463256-overview 10034902 phlebitis superficial AE a skin AE that results in the patient's skin becoming diseased due to exposure to sunlight SZ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/photodermatosis Secondary Source http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063367/ 10051246 photodermatosis AE HPO: HP_0000992 SIDER: C0920193 a skin AE that shows a cutaneous disease as a result of sun allergy and may be induced by different triggers such as a chemical. MedDRA: 10034972 and UMLS CUI: C0162830 are for "photosensitivity reaction"; MedDRA: 10034966 and UMLS CUI: C0349506 are for "photosensitivity". SZ, SS, YH, MW photosensitivity AE WEB: http://emedicine.medscape.com/article/1049648-overview WEB: http://www.merckmanuals.com/home/skin-disorders/sunlight-and-skin-damage/photosensitivity-reactions 10034966 10034972 photosensitivity reaction AE CTCAE: E13680 HPO: HP_0000992 NCIt: C38004 SIDER: C0162830 UMLS CUI: C0349506; UMLS CUI: C0162830 a skin AE that has an outcome of loss or reduction in human skin color, may be related to loss of melanocytes or inability of melanocytes to produce melanin SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/skinpigmentationdisorders.html 10062080 pigmentation disorder AE HPO: HP_0001000 SIDER: C0549567 a conduction system disorder AE that refers to partial or complete block of electrical impulses originating in the atrium or sinus node, preventing them from reaching the AV node and ventricles SS AV block heart block WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 10003671 atrioventricular block AE HPO: HP_0001678 SIDER: C0004245 a respiratory system AE that has an outcome of fluid buildup between the layers of tissue that line the lungs and chest cavity SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001150/ 10035598 pleural effusion AE CTCAE:E13486 HPO: HP_0002202 NCIt:C3331 SIDER: C0032227 a hemorrhage AE that has an outcome of bleeding in the pleural cavity, the potential space between the two pleura of the lungs MedDRA: 10035601 is for "pleural haemorrhage"; MedDRA: 10055319 is for "pleural hemorrhage". SZ, SS, YH pleural haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/hemothorax 10035601 10055319 pleural hemorrhage AE CTCAE: E13492 NCIt: C50582 UMLS CUI: C0019123 a lung disorder AE that has an outcome of inflammation of the lining of the lungs and chest that leads to chest pain SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002347/ 10035618 pleurisy AE HPO: HP_0002102 SIDER: C0032231 a pain AE induced by inflammation in the lungs that is characterized by sharp or stabbing pain in the chest SZ, SS, YH, MW WEB: http://pleuriticchestpain.net/, http://medical-dictionary.thefreedictionary.com/Pleuritic+chest+pain 10035623 pleuritic pain AE CTCAE:E13498 NCIt:C78564 a gastrointestinal disorder AE that results in gas cysts developing within the walls of the small or large intestine SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/9530294 10057030 pneumatosis intestinalis AE a pneumonia AE that has an outcome of a fungal infection of the lungs by Pneumocystis jiroveci SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001692/ 10064108 pneumocystis jiroveci pneumonia AE HPO: HP_0002096 SIDER: C1535939 Respiratory System AE that results in air being present in the mediastinum SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001148/ 10050184 pneumomediastinum AE a pneumonia AE that has an outcome of inflammation in the lungs and airways to the lungs from breathing in foreign material SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000121.htm 10035669 pneumonia aspiration AE HPO: HP_0002100 SIDER: C0032290 a pneumonia AE that has an outcome of an acute systemic disease with involvement of the lungs, caused by Mycoplasma pneumoniAE and marked by high fever and cough SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/primary+atypical+pneumonia 10035730 pneumonia primary atypical AE a lung inflammation AE located in the lung tissue SZ, SS, YH, MW pulmonitis AE WEB: http://medical-dictionary.thefreedictionary.com/pneumonitis 10035742 pneumonitis AE CTCAE:E13502 NCIt:C3333 a lung disorder AE that has an outcome of a collapsed lung due to collection of air in the space around the lungs. SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001151/ 10035759 pneumothorax AE CTCAE:E13508 HPO: HP_0006522 NCIt:C38006 SIDER: C0032326 a urinary system AE that results in abnormally frequent urination SZ, SS, YH frequent micturition AE polyuria AE WEB: http://www.merriam-webster.com/medical/pollakiuria 10036018 pollakiuria AE HPO: HP_0000103 SIDER: C0042023 a hematopoietic disorder AE that results in the bone marrow producing too many red blood cells SZ, SS, YH polycythaemia vera AE WEB: http://medical-dictionary.thefreedictionary.com/Polycythaemia+vera 10036057 polycythemia vera AE a hypertension AE located in the heptatic portal system caused by obstruction or occlusion that produces splenomegaly and ascites in its later stages SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21129318 http://www.merriam-webster.com/medlineplus/portal%20hypertension 10036200 portal hypertension AE CTCAE: E11238 HPO: HP_0001409 NCIt: C3119 SIDER: C0020541 a thrombosis AE that has an outcome of formation of a blood clot affecting the hepatic portal vein, can lead to hypertension or reduction of blood supply to the liver SZ, SS, YH PVT WEB: http://medical-dictionary.thefreedictionary.com/portal+vein+thrombosis 10036206 portal vein thrombosis AE CTCAE: E11243 NCIt: C78565 a syndrome that results in the patient suffering a set of problems after having a spinal tap procedure SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19921503 10060854 post lumbar puncture syndrome AE Fever AE that results in a fever occurring after an operation SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22774619 10050087 postoperative fever AE A thrombosis AE that occurs after an operation that results in a blood clot in a blood vessel disrupting blood flow throughout the body SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19756494 10050902 postoperative thrombosis AE Female reproductive system AE that results in the patient getting pregnant even when using a contraceptive SZ, SS, YH 10067667 pregnancy on contraceptive AE a perinatal AE that has an outcome of premature baby SZ, SS, YH 10036590 premature baby AE a pregnancy AE that has an outcome of labor beginning prior to the 37th week of gestation SZ, SS, YH premature labour AE preterm labor AE WEB: http://wordnetweb.princeton.edu/perl/webwn?s=premature%20labor 10036600 premature labor AE a sensory capability AE that has an outcome of a near-fainting episode which may include lightheadedness, dizziness, severe weakness, blurred vision, which may precede syncopal episode SZ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/presyncope 10036653 presyncope AE CTCAE:E12778 HPO: HP_0002321 NCIt:C80100 SIDER: C0700200 a bone disorder AE that has an outcome of a piece of dead bone that completely separates from sound bone during the process of necrosis SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/primary+sequestrum 10052460 primary sequestrum AE a coronary artery disorder AE that results in cardiac pain at rest that occurs in cycles SZ, SS, YH Prinzmetal's angina AE coronary vessel spasm AE WEB: http://medical-dictionary.thefreedictionary.com/prinzmetal+angina 10036759 prinzmetal angina AE HPO: HP_0001681 SIDER: C0002963 a digestive system AE that results in the pain located at the anus or in the rectum SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/proctalgia 10036772 proctalgia AE HPO: HP_0004378 SIDER: C0034886 A medical intervention that is a procedure occuring in the inside structures of the tooth, including the dental pulp and tooth root, and the periapical tissue surrounding the root. YH, SS WEB: http://medical-dictionary.thefreedictionary.com/endodontic 10051085 endodontic procedure A medical intervention that creates a passage of a tube through the nose or mouth into the trachea for maintenance of the airway, as during the administration of anesthesia. YH, SS WEB: http://medical-dictionary.thefreedictionary.com/Endotracheal+intubation 10067450 endotracheal intubation A surgery that has an outcome of the removal of part or all of the stomach. YH, SS WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002945.htm 10061965 gastrectomy a cough AE that has an outcome of secretions that could be mucous or blood SZ, SS, YH, MW WEB: http://coldflu.about.com/od/glossary/g/productivecough.htm 10036790 productive cough AE CTCAE:E13517 NCIt:C78569 a tumor AE that has an outcome of cancer that starts in the prostate gland, the small structure that wraps around the urethra carrying urine out of the body SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/ 10060862 prostate cancer AE HPO: HP_0012125 SIDER: C0376358 a physical examination result abnormal AE that results in a prostate exam being different than expected SZ, SS, EB 10055025 prostate examination abnormal AE a male reproductive system AE that has an outcome of an increased amount of prostatic specific antigen, a glycoprotein enzyme present in small quantities in the serum of men with healthy prostates. May indicate prostate cancer or prostate disorders SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23277770 10036975 prostatic specific antigen increased AE a protein and chemistry analysis result abnormal AE that is characterized by the protein level in the body being abnormal SZ, SS, YH, EB 10037012 protein total abnormal AE a prothrombin level abnormal AE that is characterized by a decrease in level of prothrombin in body SZ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/prothrombin 10037050 prothrombin level decreased AE a prothrombin time abnormal AE that has an outcome of prolonged time for plasma in the blood to clot SZ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003652.htm 10037063 prothrombin time prolonged AE a digestive system AE that has an outcome of infection in the large intestine with an overgrowth of Clostridium difficile bacteria SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001305/ 10037128 pseudomembranous colitis AE HPO: HP_0002583 SIDER: C1257843 a bacterial infection AE that has an outcome of infection by genus Pseudomonas, typically targets respiratory tract SZ, SS, YH WEB: http://emedicine.medscape.com/article/970904-overview 10061471 pseudomonas infection AE HPO: HP_0005429 SIDER: C0033817 a psychiatric disorder AE that results in physical pain being caused by the patient's life stresses SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/psychosomatic+disease 10049587 psychosomatic disease AE A mental disorder AE that results in abnormal condition of the mind SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/psychotic+disorder 10061920 psychotic disorder AE HPO: HP_0000709 SIDER: C0033975 an adverse event causality evidence that has an outcome of biological plausity. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. evidence of biological plausity of adverse event causality a lung disorder AE that has an outcome of hypertension or abnormally high blood pressure in the arteries of the lungs SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/ 10064911 pulmonary arterial hypertension AE HPO: HP_0002092 SIDER: C2973725 a lung disorder AE that has an outcome of engorgement of pulmonary vessels with transudation of fluid into the alveolar and interstitial spaces, seen in cardiac disease, infections, and certain injuries SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/pulmonary+congestion 10037368 pulmonary congestion AE HPO: HP_0004930 SIDER: C0242073 an arterial embolism AE that results in the blockage of the main artery of a lung or one of its branches by a substance that has travelled from elsewhere in the body through the bloodstream [SS] moved by relation 'SubclassOf' from lung disorder AE to arterial embolism on 01/07/14 SZ, SS, YH pulmonary artery thrombosis AE pulmonary thrombosis AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299609 10037377 10037437 pulmonary embolism AE HPO: HP_0002204 SIDER: C0034065 a lung disorder AE wih the outcome of damaged or scarred lung tissue. Thickened tissue impairs lung function SZ, SS, YH, MW WEB: http://www.mayoclinic.com/health/pulmonary-fibrosis/DS00927 10037383 pulmonary fibrosis AE CTCAE:E13527 HPO: HP_0002206 NCIt:C26869 SIDER: C0034069 a lung disorder AE that has an outcome of acute bleeding from the lung, especially in the upper respiratory tract and the endotracheal tube SZ, SS, YH pulmonary haemorrhage AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23217914 10037394 pulmonary hemorrhage AE a lung disorder AE that has an outcome of abnormally high blood pressure in the arteris of the lungs SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/ 10037400 pulmonary hypertension AE CTCAE:E13539 HPO: HP_0002092 NCIt:C3120 SIDER: C0020542 a lung disorder AE that has an outcome of an abnormal spot in the lungs that is more than 3 cm in size SZ, SS, YH WEB: http://lungcancer.about.com/od/whatislungcancer/a/Lung-Mass.htm 10056342 pulmonary mass AE a lung disorder AE that has an outcome of edema or abnormal buildup of fluid in the air sacs of the lungs, leads to shortness of breath MedDRA: 10037423 is for "pulmonary oedema"; MedDRA: 10037375 is for "pulmonary edema" SZ, SS, YH, MW pulmonary oedema AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001195/ pulmonary edema AE CTCAE: E13521 HPO: HP_0100598 NCIt: C26868 SIDER: C0034063 UMLS CUI: C0034063 a cardiovascular disorder AE that has an outcome of an inability to detect pulse SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003078.htm 10037469 pulse absent AE a cardiovascular disorder AE that has an outcome of abnormally low pulse pressure, less than 25% of systolic value. Can indicate blood loss or low stroke volume SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/pulse+pressure 10037480 pulse pressure decreased AE an adverse event with an outcome of the release or secretion of pus SZ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=21858 10037569 purulent discharge AE a kidney disorder AE that is characterized by the dilation of calices, usually due to obstruction or infection SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/calicectasis 10061927 pyelocaliectasis AE an injury AE caused by ionizing radiation SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Radiation+Injuries 10037760 radiation injury AE a digestive system AE that results in the inflammation of mucous membranes lining the digestive tract. Caused by radiation, can lead to mouth sores SZ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=19881 10037763 radiation mucositis AE a digestive system AE that has an outcome of inflammation that radiation causes swelling of the esophagus SZ, SS, YH radiation oesophagitis AE WEB: http://medical-dictionary.thefreedictionary.com/esophagitis 10048899 radiation esophagitis AE a lung inflammation AE due to radiation therapy SZ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=8091 10037765 radiation pneumonitis AE a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation SZ, SS, YH WEB: http://www.bt.cdc.gov/radiation/criphysicianfactsheet.asp 10063562 radiation skin injury AE NCIt: C3349 a respiratory system AE that has an outcome of clicking, rattling or crackling noises made by one or both lungs during inhalation SZ, SS, YH Crackles WEB: http://medical-dictionary.thefreedictionary.com/crackles 10037833 rales AE a rash ae adverse event that results in redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin SZ, SS, YH rash erythematous AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23145421 10037855 erythematous rash AE HPO: HP_0007432 SIDER: C0234913 a rash AE occuring in several areas of the body SZ, SS, YH rash (generalized) AE rash generalised AE WEB: http://www.freemd.com/rash-generalized/overview.htm 10037858 generalized rash AE HPO: HP_0000988 SIDER: C0497365 a rash AE that has an outcome of an unpleasant sensation of the skin that provokes the uge to scratch SZ, SS, YH WEB: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/pruritus-itch/ 10037884 rash pruritic AE an inflammation AE that has an outcome of an inflammatory reaction limited to a previously X-irradiated field when the patient is treated months/years later with certain drugs SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/7577597 10060856 recall phenomenon AE Digestive System AE that results in bleeding in the rectal area SZ, SS, YH rectal haemorrhage AE 10038063 10038064 rectal hemorrhage AE CTCAE: E10955 HPO: HP_0002573 NCIt: C27054 SIDER: C0267596 a red blood cell count abnormal AE that has an outcome of a decrease in red blood cells SZ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003644.htm 10038153 red blood cell count decreased AE HPO: HP_0001903 SIDER: C0427457 a digestive system disorder AE that results in the inflammation of the stomach lining due to reflux SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/gastritis 10057969 reflux gastritis AE a digestive system AE located in the esophagus, can present with heartburn, and nausea, caused by gastroesophageal reflux disease SZ, SS, YH reflux oesophagitis AE WEB: http://medical-dictionary.thefreedictionary.com/esophagitis 10038263 reflux esophagitis AE HPO: HP_0100633 SIDER: C0014869 a kidney disorder AE that results in kidneys failing to adequately filter toxins and waste from the blood SZ, SS, YH kidney failure AE renal insufficiency AE WEB: http://medical-dictionary.thefreedictionary.com/renal+failure 10038435 renal failure AE HPO: HP_0000083 SIDER: C0035078 a kidney disorder AE that results in the rapid loss or decline of kidney function As shown on the renal.org website (http://www.renal.org/guidelines/modules/acute-kidney-injury), Acute kidney injury (AKI) has now replaced the term acute renal failure. SZ, SS, YH, Izabela Birsanescu, MW AKI renal failure acute AE WEB: http://medical-dictionary.thefreedictionary.com/acute+renal+failure WEB: http://www.mayoclinic.org/diseases-conditions/kidney-failure/basics/definition/con-20024029 10038436 10069339 Acute kidney failure occurs when kidneys become unable to filter waste products from blood. acute kidney injury AE CTCAE:E12973 HPO: HP_0001919 NCIt:C26808 SIDER: C0022660 a kidney disorder AE that results in the kidneys failing to adequately filter toxins and waste from the blood SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23263712 10062237 renal impairment AE HPO: HP_0000082 SIDER: C0341697 kidney disorder AE that results in the renal tubule wasting away and losing strength/functional abilities SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/nephron 10038536 renal tubular atrophy AE a kidney disorder AE that results in the renal artery narrowing SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/renal+artery+stenosis 10038553 renal vessel disorder AE Respiratory system AE that is characterized by conditions that affect organs and systems that deal with gas exchange SZ, SS, YH WEB: http://www.thefreedictionary.com/respiratory+disorder 10038683 respiratory disorder AE HPO: HP_0002086 SIDER: C0035204 a respiratory system AE that has an outcome of a condition where lungs cannot remove all the carbon dioxide the body produces, makes body fluid too acidic SZ, SS, YH respiratory failure AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001154/ 10038695 respiratory acidosis AE CTCAE:E13545 HPO: HP_0004877 NCIt:C26872 SIDER: C1145670 a respiratory system AE that has an outcome of a ventilory rate greater than 20 breaths per minute SZ, SS, YH WEB: http://www.thefreedictionary.com/tachypnea 10038712 respiratory rate increased AE Respiratory System AE that results in bleeding somewhere in the respiratory system SZ, SS, YH respiratory tract haemorrhage AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/8692086 10038727 respiratory tract hemorrhage AE an infection AE that has an outcome of infection in the respiratory tract, includes pneumonia as well as lung abscess and acute bronchitis SZ, SS, YH WEB: http://www.thefreedictionary.com/respiratory+tract+infection 10062352 respiratory tract infection AE HPO: HP_0002873 SIDER: C0035243 an eye disorder AE that has an outcome of bleeding in the eye SZ, SS, YH retinal haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/retinal+hemorrhage 10038867 retinal hemorrhage AE HPO: HP_0000573 SIDER: C0035317 Eye Disorder AE that results in a tearing of retinal pigment epithelial tissue SZ, SS, YH 10062971 retinal pigment epithelial tear AE Amnesia AE that results in the patient forgeting things that happened before the onset of an injury or disease SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/retrograde+amnesia 10038965 retrograde amnesia AE HPO: HP_0002354 SIDER: C0002624 an encephalopathy AE that is characterized by headache, confusion, seizures and visual loss, tends to resolve over time SZ, SS, YH, MW 10063761 reversible posterior leukoencephalopathy syndrome AE CTCAE:E12798 NCIt:C78598 a muscle adverse event that results in damaged skeletal muscle tissue breaks down rapidly SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/rhabdomyolysis 10039020 rhabdomyolysis AE HPO: HP_0009045 SIDER: C0035410 a right ventricular dysfunction AE that has an outcome of congestive heart failure manifested by distention of the neck veins, enlargement of the liver, and dependent edema SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/right+ventricular+failure 10039163 right ventricular failure AE HPO: HP_0001708 SIDER: C2939447 A pregnancy AE that results in the growing pregnancy in a woman's fallopian tube becoming larger than the tube and causing it to rupture SZ, SS, YH WEB: http://www.freemd.com/ruptured-ectopic-pregnancy/overview.htm 10048407 ruptured ectopic pregnancy AE an abnormal salivary gland physiology AE that results in the salivary glands becoming irritated and/or swollen SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/salivaryglanddisorders.html 10061935 salivary gland disorder AE HPO: HP_0010286 SIDER: C0036093 a skin AE that has an outcome of a hard coating formed during the wound healing reconstruction phase SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/scab 10039509 scab AE HPO: HP_0007564 SIDER: C0205204 a nervous system AE that results in the sciatic nerve losing its sensory capabilities SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21995439 10039670 sciatic nerve injury AE an eye disorder AE that is characterized by an excessive accumulation of blood in the eye SZ, SS, YH scleral hyperaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hyperaemia 10052130 scleral hyperemia AE a dementia AE that results in an elderly patient suffering from dementia SZ, SS, YH 10039966 senile dementia AE a sensory capability AE that results in the patient feeling their blood flow SZ, SS, YH 10039996 sensation of blood flow AE a shock AE that has an outcome of life-threatening low blood pressure SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001689/ 10040070 septic shock AE HPO: HP_0002718 SIDER: C0036983 a surgery that leads to the excision of a sequestrum, or a piece of dead bone that has become separated during the process of necrosis SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sequestrectomy 10053437 sequestrectomy Blood cell lab test abnormal AE showing an increase in the number of immature leukocytes in peripheral blood. (in hematology) a predominance of immature leukocytes noted in a differential white blood cell count. It is usually indicative of an infection or inflammation. The term derives from a graph of blood components in which immature cell frequencies appear on the left side of the graph. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/shift 10056383 shift to the left AE a physiological shock AE that has an outcome of hypovolemic shock resulting from acute hemorrhage and characterized by hypotension, tachycardia, oliguria, and by pale, cold and clammy skin SZ, SS, YH shock haemorrhagic AE WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+shock 10049771 shock hemorrhagic AE a gastrointestinal disorder AE that results in the sigmoid colon being inflamed SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sigmoiditis 10052058 sigmoiditis AE a respiratory system AE that has an outcome of disease in the air-filled spaces that surround the nasal cavity, above the eyes and behind the ethmoids SZ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/paranasal+sinuses 10062244 sinus disorder AE CTCAE:E13560 NCIt:C26843 a tachycardia AE that has an outcome of elevated impulses originating from the sinoatrial node, greater than 100 bpm SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sinus+tachycardia 10040752 sinus tachycardia AE CTCAE: E10214 HPO: HP_0001649 NCIt: C26889 SIDER: C0039239 a skin AE that is characterized by sore, cracked, or rough skin, usually on the hands, face and lips. SZ, SS, YH WEB: http://wellbeing.doctissimo.com/wellbeing-a-z/chapped-skin.html 10040813 skin chapped AE a skin AE that results in linear-like cleavages in the skin SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/fissure 10040849 skin fissures AE a skin AE that has an outcome of bleeding at the skin SZ, SS, YH skin haemorrhage AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm 10064265 skin hemorrhage AE HPO: HP_0000967 SIDER: C0852361 a skin AE that has an outcome of darkening in an area of skin or nails caused by increased melanin SZ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/hyperpigmentation 10040865 skin hyperpigmentation AE CTCAE:E13718 HPO: HP_0010284 NCIt:C79731 SIDER: C0162834 a skin AE that has an outcome of infection. Can be bacterial, fungal, parasitic or viral SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/skin+infection 10040872 skin infection AE CTCAE: E11568 HPO: HP_0001581 NCIt: C35025 SIDER: C0037278 a skin AE that has an outcome of a jagged wound, can be shallow cuts or deep gahes that penetrate through muscle to internal organs and bone SZ, SS, YH WEB: http://www.mdguidelines.com/lacerations 10058818 skin laceration AE a skin AE that has an outcome of a superficial growth or patch of the skin that does not resemble the area surrounding it SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Skin+Lesions 10040882 skin lesion AE HPO: HP_0011355 SIDER: C0037284 a skin AE that has an outcome of exposure of skin to nonspecific irritants or from the action of specific allergens SZ, SS, YH WEB: http://encyclopedia2.thefreedictionary.com/Skin+Reactions 10040914 skin reaction AE a skin AE that has an outcome of irritation, sensitization and phototoxicity SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/dermal+toxicity 10059516 skin toxicity AE a behavior and neurological AE that results in irregular sleep patterns SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sleep+disorder 10040984 sleep disorder AE HPO: HP_0002360 SIDER: C0851578 an eating disorder AE that is characterized by patient searching for food while asleep SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23205019 10067315 sleep-related eating disorder AE a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the small intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors SZ, SS, YH WEB: http://www.mayoclinic.com/health/intestinal-obstruction/DS00823 10041101 small intestinal obstruction AE CTCAE: E11021 HPO: HP_0005214 NCIt: C78615 SIDER: C0235329 a surgery that is characterized by all of or part of the small intestine needing to be removed SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002943.htm 10041105 small intestinal resection a gastrointestinal disorder AE in which the blood vessels in the small intestine narrow SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/stenosis 10062263 small intestinal stenosis AE CTCAE: E11032 NCIt: C78617 a tumor AE that results in cancer in the small intestine SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/small+intestine+cancer 10054184 small intestine carcinoma AE a gastrointestinal disorder AE that results in an ulcer in the patient's small intestine SZ, SS, YH 10041133 small intestine ulcer AE CTCAE: E11038 NCIt: C78619 a connective tissue disorder AE that occurs in the non-skeletal tissue, usually subcutaneous and muscle tissue SZ, SS, YH WEB: http://www.reference.md/files/D018/mD018461.html 10062255 soft tissue infection soft tissue infection AE CTCAE: E11579 HPO: HP_0002719 NCIt: C79745 SIDER: C0149778 a connective tissue disorder AE that results in damage to muscles, ligaments, and tendons throughout the body SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22964676 10041291 soft tissue injury AE a necrosis AE that results in necrosis occurring in soft tissue SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/necrosis 10065769 soft tissue necrosis AE a behavior and neurological AE that results in the patient hvings a mental disorder with symptoms that may suggest physical illness or injury SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/somatoform+disorder 10054153 somatoform disorder AE a bone disorder AE that has an outcome of vertebra collapse caused by small hairline fractures SZ, SS, YH WEB: http://www.webmd.com/osteoporosis/guide/spinal-compression-fractures-causes 10041541 spinal compression fracture AE a nervious system AE that has an outcome of spinal cord compressed by bone fragments from a vertebral fracture, a tumor, abscess, ruptured intervertebral disc or other lesion SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/spinal+cord+compression 10041549 spinal cord compression AE HPO: HP_0002176 SIDER: C0037926 Tumor AE that results in a tumor in the patient's spinal cord SZ, SS, YH 10062261 spinal cord neoplasm AE Spinal osteoarthritis AE is a osteoarthritis AE that has an outcome of degeneration of the protective cartilage that cushions the tops of bones, causes swelling and pain and may cause development of osteophytes. SZ, SS, YH WEB: http://www.webmd.com/osteoarthritis/guide/spinal-osteoarthritis-degenerative-arthritis-of-the-spine 10041591 spinal osteoarthritis AE HPO: HP_0002758 SIDER: C0949690 an immune system disorder AE that has an outcome of a larger-than-normal spleen, affects blood filtration SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003276.htm 10041660 splenomegaly AE HPO: HP_0001744 SIDER: C0038002 a microbiology and serology investigation result abnormal AE that has an outcome of bacterial infection in the lungs or breathing passages SZ, SS, YH, EB WEB: http://www.webmd.com/lung/sputum-culture 10051612 sputum culture positive AE a respiratory system AE that shows increased sputum, which results in mucous material coughed up from the lungs by the patient. SZ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=5539 10041812 sputum increased AE HPO: HP_0002105 SIDER: C0235567 a skin AE that has an outcome of a type of nonmelanoma skin cancer SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001832/ 10041823 squamous cell carcinoma AE HPO: HP_0006739 SIDER: C0007137 a bacterial infection AE that has an outcome of invasion by Staphylococcus, can present with pus, fever, chills and low blood pressure SZ, SS, YH WEB: http://www.medicinenet.com/staph_infection/page2.htm 10058080 staphylococcal infection AE HPO: HP_0007499 SIDER: C0038160 a skin AE that results in the skin in the leg undergoing discoloration due to blood pooling as a result of insufficient venous return SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000834.htm 10041955 stasis dermatitis AE a device occlusion AE that has an outcome of blockage of the stent, or a tube inserted into body to prevent or counteract a disease-induced, localized flow constriction SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002303.htm 10049936 stent occlusion AE a skin adverse event that is characterized by cell death causing the epidermis to separate from the dermis SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001854/ 10042033 stevens-johnson syndrome AE CTCAE:E13736 HPO: HP_0000951 NCIt:C79484 SIDER: C0038325 a stress AE that results in patient experiencing stress at work SZ, SS, YH 10042210 stress at work AE an adverse event causality evidence that comes from a case report. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. adverse event causality evidence from case report a nervous system AE that has an outcome of bleeding in the area between the brain and the thin tissues that cover the brain SZ, SS, YH subarachnoid haemorrhage AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001720/ 10042316 subarachnoid hemorrhage AE HPO: HP_0002138 SIDER: C0038525 a nervous system AE that has an outcome of a collection of blood on the surface of the brain SZ, SS, YH subdural haematoma AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001732/ 10042361 subdural hematoma AE HPO: HP_0100309 SIDER: C0018946 A gastrointestinal hemorrhage AE that has an outcome of the bleeding in the stomach YH, SS gastric haemorrhage AE 10017788 10017789 gastric hemorrhage AE CTCAE: E10706 NCIt: C54582 a death AE that has an outcome of unexpected death, 1 to 24 hours after the onset of symptoms SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sudden+death 10042434 10042435 sudden death AE CTCAE: E11171 HPO: HP_0001645 NCIt: C50911 SIDER: C0011071 a psychiatric disorder AE that results in thoughts about suicide SZ, SS, YH, MW WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Suicidal+ideation Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/10193592 10042458 suicidal ideation AE CTCAE:E12964 NCIt:C80102 a psychiatric disorder AE that results in attempted suicide SZ, SS, YH, MW 10042464 suicide attempt AE CTCAE:E12969 HPO: HP_0000708 NCIt:C80111 SIDER: C0038663 a viral infection AE that has an outcome of a cell that was previously infected being coinfected with a different strain of the virus SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/superinfection 10042566 superinfection AE HPO: HP_0005364 SIDER: C0038826 a venous thrombosis AE in which a stroke occurs as a result of thrombosis. uncommon cerebrovascular accident that is frequently associated with diseases that may contribute to the development of thrombosis through hypercoagulability, stasis of the local blood stream, and abnormalities of the vessel wall. SZ, SS, YH SSST WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1026412 WEB: http://www.ncbi.nlm.nih.gov/pubmed/1455986 10042567 superior sagittal sinus thrombosis AE an arrhythmia AE that has an outcome of premature atrial contractions or beats caused by signals originating from ectopic atrial sites SZ, SS, YH WEB: http://sideeffects.embl.de/se/C0033036/ 10042602 supraventricular extrasystoles AE HPO: HP_0005115 SIDER: C0033036 a tachycardia AE that has an outcome of rapid heart rhythm originating at or above the atrioventricular node SZ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001235/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23233691 10042604 supraventricular tachycardia AE CTCAE: E10218 HPO: HP_0004765 NCIt: C35061 SIDER: C0039240 Adverse event that is characterized by the patient becoming increasingly suspicious SZ, SS, YH 10042635 suspiciousness AE an injury and procedural complication AE that results in a complication resulting from a suture SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/17276274 10059059 suture related complication AE a surgery AE that results in a suture being used to hold body tissues together, ruptures SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21266279 10048547 suture rupture AE an increased heartbeat AE that is characterized by a distburance of the heart rhythm in which heart rate is abnormally increased SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/tachyarrhythmia 10049447 tachyarrhythmia AE HPO: HP_0001649 SIDER: C0080203 a tachycardia AE that results in tachycardia beginings and ending in an acute manner SZ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/11208235 Secondary Source: http://www.nlm.nih.gov/medlineplus/ency/article/000183.htm 10043079 tachycardia paroxysmal AE an abnormal repiration AE that shows an outcome of tachypnoea (i.e., abnormally rapid breathing or respiration) SZ, SS, YH tachypnoea AE 10043089 tachypnea AE HPO: HP_0004346 SIDER: C0231835 an adverse event causality evidence that comes from the study of a case report series. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. adverse event causality evidence from case series Behavior and neurological AE that results in the patient having recurring seizures SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001714/ 10043209 temporal lobe epilepsy AE An immune system disorder AE that is a complication that can occur after a stem or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body YH, SS GVHD WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm 10018651 graft versus host disease AE a hematopoietic system AE that has an outcome of too many blood platelets or thrombocytes, can result in headache, lightheadedness, vision changes and limb numbness SZ, SS, YH thrombocythaemia AE WEB: http://www.mayoclinic.com/health/thrombocythemia/DS01087 10015493 thrombocythemia AE a hematopoietic system AE that has an outcome of decrease in platelets in the blood SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000586.htm 10043554 thrombocytopenia AE HPO: HP_0001873 SIDER: C0040034 a phlebitis AE located in the vein, caused by a blood clot SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002098/ WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001108.htm 10043570 thrombophlebitis AE HPO: HP_0004418 SIDER: C0040046 a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583 WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/18215115 Secondary Source: http://www.nejm.org/doi/full/10.1056/NEJMra020528 10043645 thrombotic microangiopathy AE HPO: HP_0002597 SIDER: C2717961 a tumor AE that results in a benign tumor in the thyroid SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004524/ 10043688 thyroid adenoma AE HPO: HP_0000854 SIDER: C0151468 a tumor AE that results in the patient hvings a mass growing in their thyroid SZ, SS, YH 10058900 thyroid mass AE an arrhythmia AE that has an outcome of an irregular rate of the heartbeat YH, SS 10019304 heart rate irregular AE HPO: HP_0011675 SIDER: C0237314 a syndrome AE that results in the patient suffering from withdrawal from not using tobacco SZ, SS, YH 10059612 tobacco withdrawal symptoms AE a tongue AE that has an outcome of open sores or cuts on the tongue SZ, SS, YH WEB: http://www.localhealth.com/article/tongue-ulcers 10043991 tongue ulceration AE HPO: HP_0000155 SIDER: C0235351 Tumor AE that results in cancer in the patient's tonsils SZ, SS, YH 10044002 tonsil cancer AE a bone disorder AE that has an outcome of an abscess located in the tooth or a bacterial infection in the center of a tooth SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002055/ 10044016 tooth abscess AE HPO: HP_0000164 SIDER: C0518988 a bone disorder AE that has an outcome of disease in the teeth SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/toothdisorders.html 10044034 tooth disorder AE HPO: HP_0000164 SIDER: C0040435 a bone disorder AE that has an outcome of a break or rupture in a bone SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/tooth+fracture 10062544 tooth fracture AE a bone disorder AE that has an outcome of one or more teeth coming loose and falling out SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23253824 10044044 tooth loss AE HPO: HP_0006349 SIDER: C0080233 a bone disorder AE that has an outcome of an aching pain in or around a tooth SZ, SS, YH odontalgia AE WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/toothache Seconday Source: http://www.ncbi.nlm.nih.gov/pubmed/22157099 10044055 toothache AE CTCAE: E11054 HPO: HP_0000164 NCIt: C78640 SIDER: C0040460 a endocrine system AE that has an outcome of an excess production of thryoid hormone, characterized by functionally autonomous nodules SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000317.htm 10044242 toxic nodular goitre AE A liver AE that has an outcome of an abnormal functionality of the liver YH, SS hepatic function abnormal AE HPO: HP_0001410 SIDER: C0086565 a respiratory system AE that results in the trachea being infected by a bacteria SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001983/ 10044302 10066798 tracheitis AE CTCAE: E11599 NCIt: C78647 a respiratory system AE that is characterized by the inflammation of the muscous membranes of the trachea and bronchi SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/tracheobronchitis 10044314 tracheobronchitis AE HPO: HP_0002837 SIDER: C0040586 a behavior and neurological AEthat results in the patient being in a state of trance SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/trance 10044334 trance AE a transaminase level abnormal AE that has an outcome of elevated levels of alanine transaminase and aspartate transaminase SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Transaminases 10054889 transaminase level increased AE A cardiomyopathy AE that has an outcome of a condition in which the heart muscle becomes thick. Often, only one part of the heart is thicker than the other parts. The thickening can make it harder for blood to leave the heart, forcing the heart to work harder to pump blood. It also can make it harder for the heart to relax and fill with blood. YH, SS HCM WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001243/ 10020871 hypertrophic cardiomyopathy AE HPO: HP_0001639 SIDER: C0007194 a vascular disorder AE that results in an abnormal spatial arrangement of any of the primary blood vessels SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002535/ 10044443 transposition of the great vessels AE a blood chloride abnormal AE that is characterized by an abnormally high level of chloride in the blood YH, MW 10020599 hyperchloremia AE UMLS CUI: C0085679 a cardiac valve disease AE that is characterized by a tricuspid valve that does not close tightly enough to prevent leakage SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Tricuspid+Valve+Insufficiency 10044640 tricuspid valve incompetence AE a tri-iodothyronine level abnormal AE that results in a decreased level of tri-iodothyronine SZ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/Tri-iodothyronine 10044594 tri-iodothyronine decreased AE a troponin level abnormal AE that has an outcome of an increased amount of troponin, a protein released when the heart muscle is damaged SZ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007452.htm 10058267 troponin level increased AE a bacterial infection AE that is caused by M. tuberculosis. SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001141/ 10044755 tuberculosis AE a surgery that removes a tumour SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Tumor+Removal 10061392 tumour excision Tumor AE that results in a tumor reoccurring SZ, SS, YH tumour flare AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/21523725 10045169 tumor flare AE an hemorrhage AE that has an outcome of bleeding in the tumour SZ, SS, YH tumour haemorrhage AE WEB: http://calder.med.miami.edu/pointis/tbifam/cause3.html 10049750 tumour hemorrhage AE a syndrome AE that has an outcome of a group of metabolic complications that can occur after treatment of cancer SZ, SS, YH tumour lysis syndrome AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/15384972 10045152 10045170 tumor lysis syndrome AE CTCAE: E12365 NCIt: C3425 a cytogenetic investigation result abnormal AE that has an outcome of an increase in a substance found in the blood, urine, or body tissues that can be elevated in cancer, among other tissue types SZ, SS, YH, EB tumour marker increased AE WEB: http://www.cancer.gov/cancertopics/factsheet/detection/tumor-markers 10048621 tumor marker increased AE a necrosis AE that has an outcome of death of tumor tissue, tumor rapidly outgrows its blood supply SZ, SS, YH tumour necrosis AE WEB: http://medical-dictionary.thefreedictionary.com/tumor+necrosis 10054094 tumor necrosis AE a keratitis AE that has an outcome of disrupted epithelial layer and stroma of the cornea, may become blind SZ, SS, YH corneal ulcer AE WEB: http://medical-dictionary.thefreedictionary.com/Ulcerative+keratitis 10064996 ulcerative keratitis AE HPO: HP_0007812 SIDER: C0010043 Homeostasis AE that results in an inability to achieve adequate fluid balance SZ, SS, YH 10069568 ultrafiltration failure AE Respiratory system AE that is characterized by the patient having an obstruction in their upper airway SZ, SS, YH 10067775 upper airway obstruction AE HPO: HP_0002781 SIDER: C0740852 a gastrointestinal hemorrhage AE that has an outcome of bleeding in the upper gastrointestinal tract SZ, SS, YH upper gastrointestinal haemorrhage AE WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/gastrointestinal+bleeding Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1237869/ 10046274 10055356 upper gastrointestinal hemorrhage AE CTCAE: E11062 HPO: HP_0002239 NCIt: C78660 SIDER: C0041909 a urinary system AE that has an outcome of a blockage in the urinary tract, can result in pain, fever, infection, loss of kidney function, sepsis or death if severe SZ, SS, YH WEB: http://www.mayoclinic.org/ureteral-obstruction/ 10046406 ureteric obstruction AE HPO: HP_0006000 SIDER: C0041956 Urinary system AE that results in the urethra becoming obstructed SZ, SS, YH 10046459 urethral obstruction AE HPO: HP_0000796 SIDER: C0041972 Urinary System AE that results in the urethra becoming narrowed at the external meatus SZ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urethral+meatal+stenosis Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22710090 10065584 urethral stenosis AE a urinary incontinence AE that results in the patient feeling a sudden urgency or need to urinate. SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002250/ 10046494 urge incontinence AE HPO: HP_0000012 SIDER: C0150045 Urinary system AE that results in an inability to urinate SZ, SS, YH, MW WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urinary+retention Secondary Source: http://www.medtronic.com/patients/urinary-retention/index.htm 10046555 urinary retention AE CTCAE:E13046 HPO: HP_0000016 NCIt:C50790 SIDER: C0080274 a urinary tract infection AE that results in the infection of the urinary tract by the Pseudomonas Aeruginosa organism SZ, SS, YH WEB: http://www.jiph.org/article/S1876-0341(09)00058-6/abstract 10062279 urinary tract infection pseudomonal AE a urinary tract infection AE that results in the urinary tract being infected with the staphylococcal bacteria SZ, SS, YH 10062280 urinary tract infection staphylococcal AE a toxicology drug screen result abnormal AE that results in a positive result for amphetamines in the urine SZ, SS, YH, EB 10051400 urine amphetamine positive AE a urine abnormality AE that has an outcome of decreased urine output, less than 500 milliliters of urine in 24 hours SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003147.htm 10059895 urine output decreased AE CTCAE: E12217 NCIt: C80522 a urinary system AE caused by an infection in the urinary tract that has an outcome of accumulation of pus-forming bacteria or toxins in the blood of the urinary tract. SZ, SS, YH WEB: http://www.primehealthchannel.com/urosepsis-definition-symptoms-causes-diagnosis-and-treatment.html 10048709 urosepsis AE an urticaria AE that results in the appearance of "wheals" on skin SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/papular+urticaria 10046750 urticaria papular AE a uterine AE that results in uterine contractions during pregnancy SZ, SS, YH 10049975 uterine contractions during pregnancy AE a uterine AE that has an outcome of bleeding from the uterus MedDRA: 10046788 is for "uterine haemorrhage"; MedDRA: 10046789 is for "uterine hemorrhage" SZ, SS, YH, MW uterine haemorrhage AE 10046788 10046789 uterine hemorrhage AE CTCAE: E13237 HPO: HP_0000130 NCIt: C78686 SIDER: C0042134 a uterine AE that results in the patient undergoing a single uterine contraction for over two minutes during pregnancy SZ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488 10046790 uterine hypertonus AE HPO: HP_0000130 SIDER: C0269842 an infection AE that results in infection of the vagina SZ, SS, YH 10046914 vaginal infection AE CTCAE: E11624 HPO: HP_0000142 NCIt: C26911 SIDER: C0404521 a digestive system AE that has an outcome of dilated sub-mucosal veins in the lower third of the esophagus SZ, SS, YH varices oesophageal AE WEB: http://www.mayoclinic.com/health/esophageal-varices/DS00820 10056091 varices esophageal AE HPO: HP_0002040 SIDER: C0014867 a dementia AE that results in problems with reasoning, judgement, and memory resulting from brain damage from impaired blood flow to the brain SZ, SS, YH WEB: http://www.mayoclinic.com/health/vascular-dementia/DS00934 10057678 vascular dementia AE a vascular disorder AE that results in the veins becoming discoloured SZ, SS, YH vein discolouration AE 10047183 vein discoloration AE a thrombosis AE that has an outcome of a blood clot in the inferior vena cava SZ, SS, YH vena cava embolism AE WEB: http://emedicine.medscape.com/article/1933035-overview, http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm 10047193 10047195 vena cava thrombosis AE a vascular disorder AE that results in an injury to the vein(s) SZ, SS, YH 10047228 venous injury AE CTCAE: E12051 NCIt: C78711 a thrombosis AE that has an outcome of a blood clot that forms within a vein SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm 10047249 venous thrombosis AE HPO: HP_0004850 SIDER: C0042487 a cardiac ventricular disorder AE that has an outcome of an abnormality in the contraction of the ventricles or the motion of the cells SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/ventricular+dysfunction 10059056 ventricular dysfunction AE an adverse event causality evidence that comes from an uncontrolled observational study YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. adverse event causality evidence from uncontrolled observational study an ear disorder that results in irritation and swelling (inflammation) of the inner ear SZ, SS, YH lybyrinthitis AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002049/ 10047393 vestibular neuronitis AE an abnormal vision AE that results in unclear vision SZ, SS, YH blurred vision AE WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003029.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23111613 10005886 10047513 vision blurred AE CTCAE: E10346 HPO: HP_0000622 NCIt: C27123 SIDER: C0344232 an abnormal vision AE that results in a decrease in clearness of vision SZ, SS, YH WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003396.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23329671 10047531 visual acuity reduced AE HPO: HP_0000572 SIDER: C0234632 an abnormal vision AE that results in the patient suffering from an enhanced brightness in their vision SZ, SS, YH 10049155 visual brightness AE a gustatory system AE that has an outcome of a shortage of vitamin D which is essential for strong bones SZ, SS, YH WEB: http://www.webmd.com/diet/vitamin-d-deficiency 10047626 vitamin d deficiency AE HPO: HP_0100513 SIDER: C0042870 an adverse event causality evidence that comes from controlled observational studies. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 29. adverse event causality evidence from controlled observational study Inflammation AE that is characterized by an inflammatory reaction of the vitreous or hyaloid membrane as a result of disease in adjacent structures SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/vitritis 10047663 vitritis AE a physical examination result abnormal AE that shows an increase (gain) in weight of a patient SZ, SS, YH weight gain AE 10047896 10047899 weight increased AE CTCAE: E12224 HPO: HP_0004324 NCIt: C62754 SIDER: C0043094 a conduction system disorder AE that results in an abnormal accessory electrical conduction pathway between the atria and ventricles SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001206/ 10048015 wolff-parkinson-white syndrome AE CTCAE: E10244 NCIt: C35132 a wound AE that has an outcome of complication to the wound SZ, SS, YH WEB: https://en.wikipedia.org/wiki/Wound 10053692 wound complication AE CTCAE: E12057 NCIt: C78719 a wound AE that has an outcome of a wound breaking open along the surgical sutures SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/wound+dehiscence 10048031 wound dehiscence AE CTCAE: E12063 NCIt: C50863 A wound AE that has an outcome of secretions or pus produced by damaged tissue particles and repairing mechanisms intitiated by the body SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/2815962 10048629 wound secretion AE an abnormal vision AEthat results in the patient seeing a predominance of yellow in their vision SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/xanthopsia 10048216 xanthopsia AE HPO: HP_0000551 SIDER: C0221185 an immune system disorder AE that results in a fungal infection of the sinuses, brain, or lungs that occurs in some people with a weakened immune system SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001672/ 10061418 zygomycosis AE A cardiomyopathy AE that has an outcome of a heart failure with left ventricular dilatation resulting from ischemic heart disease. YH, SS ischaemic cardiomyopathy AE WEB: http://medical-dictionary.thefreedictionary.com/ischemic+cardiomyopathy 10048858 ischemic cardiomyopathy AE A surgery that is a procedure performed on the jaw YH, SS 10059242 jaw operation An adverse event that is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. YL http://en.wikipedia.org/wiki/Narcolepsy YL narcolepsy AE A medical intervention that is a life-support system designed to replace or support normal ventilatory lung function YH, SS WEB: www.medscape.com/resource/mechanical-ventilation 10067221 mechanical ventilation An inflammation AE that has an outcome of tissue swelling and other inflammatory response in the mouth YH, SS oral mucositis 10028116 10028130 mucosal inflammation AE CTCAE: E10872 NCIt: C26887 A systematic adverse event that has an outcome of failure in mulitple organs YH, SS 10028154 multi-organ failure AE CTCAE: E11155 NCIt: C75568 Pleomorphic rash AE is rash AE that is a rash characterized by many-formed. JX, LW, YH 多形性皮疹 pleomorphic rash AE A bone disorder AE that has an outcome of the weakening or brittle bone YH, SS, MW WEB: http://www.mayoclinic.com/health/osteoporosis/DS00128 10031282 osteoporosis AE CTCAE:E12508 HPO: HP_0000939 NCIt:C3298 SIDER: C0029456 A groupd of disroders where the genetic susceptibility plays an important role to the seletctive susceptibility to poorly pathogenic mycobacterial species such as bacille Calmette-Guérin and environmental mycobacteria. MSMD http://www.ncbi.nlm.nih.gov/pubmed/20718793 YL Mendelian susceptibility to mycobacterial disease A cardiomyopathy AE that has an outcome of a condition that the heart cannot relax normally during the time between heartbeats when the blood returns from the body (diastole). YH, SS infiltrative cardiomyopathy WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000189.htm 10038748 restrictive cardiomyopathy AE CTCAE: E10192 NCIt: C62798 A medical intervention that has an outcome of the transplant of stem cells into the body YH, SS 10063581 stem cell transplant an adverse event causality evidence that comes from a controlled clincal trial In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30. adverse event causality evidence from controlled clinical trial A medical intervention that has an outcome of an intersion of a tube into the body YH, SS 10048561 stent placement A cardiomyopathy AE that is a temporary heart condition brought on by stressful situations, such as the death of a loved one. People with broken heart syndrome may have sudden chest pain or think they're having a heart attack. These broken heart syndrome symptoms may be brought on by the heart's reaction to a surge of stress hormones. In broken heart syndrome, a part of your heart temporarily enlarges and doesn't pump well, while the remainder of the heart functions normally or with even more forceful contractions. YH, SS takotsubo cardiomyopathy, broken heart syndrome, stress-induced cardiomyopathy, apical ballooning syndrome WEB: http://www.mayoclinic.com/health/broken-heart-syndrome/DS01135/METHOD=print 10066286 stress cardiomyopathy AE A medical intervention that has an outcome of an extraction of the tooth YH, SS 10062132 tooth extraction A skin adverse event that has an outcome of an eruption caused by ingestion, injection, inhalation, or insertion of a drug, often a result of allergic sensitization. Also called dermatitis medicamentosa, dermatosis medicamentosa, drug rash YH, SS dermatitis medicamentosa, dermatosis medicamentosa, drug rash WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption 10057970 toxic skin eruption AE An arrythmia AE that has an outcome of a severely abnormal heart rhythm (arrhythmia) that can be life-threatening. YH, SS VF WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004467/ 10047290 ventricular fibrillation AE CTCAE: E10236 HPO: HP_0001663 NCIt: C50799 SIDER: C0042510 an atrioventricular block AE that there is some prolongation of AV conduction time (PR interval). The heart's electrical signals are slowed as they move from the atria to the ventricles (the heart's upper and lower chambers, respectively). This results in a longer, flatter line between the P and the R waves on the EKG (electrocardiogram). SS atrioventricular block first degree first degree heart block WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html 10003674 first degree atrioventricular block AE CTCAE: E10098 NCIt: C62015 A medical intervention that has an outcome of the removal of dead, damaged, dying or infected tissue. The human body is capable of (autolytic) debridement for small wounds, but for large wounds, medical procedures are necessary. YH, SS surgical debridement, enzymatic debridement, autolytic debridement, mechanical debridement WEB: http://surgery.about.com/od/glossaryofsurgicalterms/g/Debridement.htm 10048030 wound debridement A thyroiditis AE that shows a self-limited thyroid condition associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function. YL, YH SAT painless thyroiditis AE silent thyroiditis AE http://emedicine.medscape.com/article/125648-overview https://en.wikipedia.org/wiki/Subacute_lymphocytic_thyroiditis subacute thyroiditis AE Macrophagic myofasciitis (MMF) is a rare inflammatory muscle disorder characterized by a characteristic infiltration of muscle tissue by PAS-positive macrophages, which is caused by pathological persistence of vaccine-derived aluminium hydroxide. The diagnosis can only be established by an open muscle biopsy from the muscle that was used for intramuscular vaccination. YL MMF http://www.ncbi.nlm.nih.gov/pubmed/14593574 YL macrophagic myofasciitis AE BCG infection following BCG injection. It is often related with the vaccinee's immunodeficiency. YL YL disseminated BCG infection AE An adverse event that is a disorder of neural development characterized by impaired social interaction and communication, and by restricted and repetitive behavior. YL http://en.wikipedia.org/wiki/Autism autism AE HPO: HP_0000717 SIDER: C0004352 an adverse event that is a type of encephalitis triggered by vaccination. Autoimmune Encephalitis may be triggered by infection in which case the term "Post-infectious Encephalitis" is used. ADEM( Acute Disseminated Encephalomyelitis ) is a Post-infectious Encephalitis. The illness usually follows in the wake of a mild viral infection (such as those that cause rashes in childhood) or immunisations. Typically there is a delay of days to two to three weeks between the triggering infection and development of the encephalitis. It has recently been recognised that there are other types of Autoimmune Encephalitis resulting from an attack of the brain by the body's immune system. Some of these types of autoimmune encephalitis are identified by finding a specific antibody in blood. These conditions include Potassium channel complex antibody associated encephalitis, NMDAR and Hashimoto's encephalitis. http://www.encephalitis.info/information/the-illness/types-of-autoimmune-encephalitis/ YL autoimmune encephalitis AE an injection-site AE that display an redness in the injection-site YH injection-site redness AE a sensory capability AE that shows up skin tenderness and occurs in an injection site of a medical intervention YH 10043224 injection-site tenderness AE YH a movement disorder AE that has an outcome of arm motion limitation arm motion limitation AE a sensory capability AE that shows up muscular soreness at the injection site of a medical intervention YH 10028332 injection-site muscular soreness AE a sleep disorder AE that shows up sleepiness (Sluggish from sleep, inactive, quiet). YH 10041014 sleepiness AE an adverse event that occurs in brain. YH brain disorder AE brain AE a hypersensitivity AE that is mild. YH mild hypersensitivity AE YH an injection-site edema AE that occurs in the arm. injection-site arm edema AE a psychiatric disorder AE that shows restlessness YH, MW WEB: http://dictionary.reference.com/browse/restlessness 10038743 restlessness AE CTCAE:E12960 NCIt:C74533 UMLS_CUI: C0085631 a sensory capability AE that results in a sensation of induration with tenderness. YH induration with tenderness AE a sensory capability AE that results in a sensation of fussiness YH fussiness AE a sleep disorder AE that shows decreased sleep YH decreased sleep AE a sleep disorder AE that shows increased sleep YH increased sleep AE a pain AE that occurs at a joint YH joint pain AE Tiredness AE is a sensory capability AE that results in a sensation of tiredness. This term appears to be a synonym to the 'fatigue AE'. JX, LW, YH hypodynamia AE 疲劳/乏力 10043890 tiredness AE nasal discomfort AE is a respiratory system AE that shows a discomfort from the nose YH nasal discomfort AE HPO: HP_0010640 SIDER: C0858259 an adverse event causal associate score that represents a statatical P-value to address the causal adverse event hypothesis. YH adverse event causality P-value a data item that represents a statistic to summarize the extent to which a particular adverse event is observed for individuals taking a specific medical intervention (e.g., a drug), compared to the frequency at which the same adverse event occurs for patients taking some other intervention (e.g., other drug or any drug in a specified class of drugs). The PRR will typically be calculated using a surveillance database in which reports of adverse events from a variety of drugs are recorded. YH PRR WEB: http://www.ncbi.nlm.nih.gov/pubmed/11828828 proportional reporting ratio an adverse event causality P-value that is calculated out of a specific Chi-square test. YH P-value of adverse event causality Chi-square test a data item that represents a threshold cutoff for filtering out those adverse event case reports that are unlikely important for a specific AE study. This is applied to the analysis of AE case resport data in an AE case reporting system such as FAERS or VAERS. YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23209624 adverse event filtering cutoff A data item that is defined as the number of patients realized with an adverse event beginning in an interval or continuing from a previous interval divided by the number of patients taking the same medical intervention within that interval. The prevalence thus indicates the number of events that began and persisted over time. AG, YH WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf AE prevalence rate an imaging investigation result abnormal AE that is indicated by an abnormal result of a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body EB 10029816 nuclear magnetic resonance imaging result abnormal AE a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body using a dye, called oral contrast, that shows up on the CT images to help better define internal organs EB computerised tomogram with contrast abnormal AE computerized tomogram with contrast abnormal AE a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body EB computerised tomogram without contrast abnormal AE computerized tomogram without contrast abnormal AE an investigation result abnormal AE that involves an abnormal result of an investigation involving the cardiovascular system EB, YH 10007512 cardiovascular investigation result abnormal AE an atrioventricular block AE that some but not all atrial impulses fail to reach the ventricles, thus some ventricular beats are dropped. Electrical signals between the atria and ventricles are slowed to a large degree. Some signals don't reach the ventricles. On an EKG, the pattern of QRS waves doesn't follow each P wave as it normally would. SS atrioventricular block second degree second degree heart block WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html 10003677 second degree atrioventricular block AE a cardiac and vascular investigation result abnormal AE that is an abnormal result of a test that uses sound waves to create a moving picture of the heart EB 10061593 echocardiogram result abnormal AE an investigation result abnormal AE that involves an abnormal electrolyte value EB 10047843 electrolyte lab test abnormal AE an electrolyte lab test abnormal AE that shows an abnormal blood phosphorus level EB 10054823 blood phosphorus abnormal AE A physical quality that has an increased level of phosphate in the blood EB, YH, MW 10050196 blood phosphorus increased HPO: HP_0002905 SIDER: C0919625 an atrioventricular block AE that complete atrioventricular dissociation occurs; atria and ventricles beat independently. None of the electrical signals reach the ventricles. This type also is called complete heart block or complete AV block. When complete heart block occurs, special areas in the ventricles may create electrical signals to cause the ventricles to contract. This natural backup system is slower than the normal heart rate and isn't coordinated with the contraction of the atria. On an EKG, the normal pattern is disrupted. The P waves occur at a faster rate that isn't coordinated with the QRS waves. SS atrioventricular block complete complete heart block third degree atrioventricular block third degree heart block WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html 10003673 complete atrioventricular block AE CTCAE: E10093 NCIt: C50501 an electrolyte lab test abnormal AE that results in an abnormal level of potassium in the blood EB 10005722 blood potassium abnormal AE HPO: HP_0011042 SIDER: C0853759 a physical quality where the blood potassium level is increased. EB, YH, MW hyperkalemia AE 10005725 blood potassium increased HPO: HP_0002513 SIDER: C0853760 an electrolyte lab test abnormal AE that results in an abnormal level of sodium in the blood EB 10005800 blood sodium abnormal AE A physical quality that has an increased level of sodium in the blood EB, YH, MW 10005803 blood sodium increased HPO: HP_0003228 SIDER: C0595878 an electrolyte lab test abnormal AE that results in an abnormal level of magnesium in the blood EB 10005652 blood magnesium abnormal AE A physical quality that has an increased level of magnesium in the blood EB, YH, MW 10005655 blood magnesium increased an electrolyte lab test abnormal AE that results in an abnormal level of chloride in the blood EB 10005417 blood chloride abnormal AE A physical quality that has an increased level of chloride in the blood EB 10005420 blood chloride increased an electrolyte lab test abnormal AE that results in an abnormal level of calcium in the blood EB 10005393 blood calcium abnormal AE A physical quality that has an increased level of calcium in the blood EB, YH, MW 10005396 blood calcium increased an investigation result abnormal AE that involves the renal and urinary tract and urinalyses EB, YH renal and urinary tract investigation and urinalysis result abnormal AE renal system investigation result abnormal AE 10038362 urinary system investigation result abnormal AE a urinary system investigation result abnormal AE that is characterized by an abnormal level of creatinine in the blood EB 10005481 blood creatinine level abnormal AE a urinary system investigation result abnormal AE that is characterized by an abnormal level of urea in the blood EB 10005846 blood urea level abnormal AE an investigation result abnormal AE that involves an abnormal result of a lipid analyses EB 10024580 lipid analysis result abnormal AE a lipid analysis result abnormal AE that results in an abnormal blood cholesterol level EB 10005423 blood cholesterol abnormal AE a blood cholesterol abnormal AE that results in a decreased amount of cholesterol in the blood EB 10005424 blood cholesterol decreased AE a lipid analysis result abnormal AE that is characterized by an abnormal amount of high density lipoprotein EB 10020051 high density lipoprotein abnormal AE a high density lipoprotein abnormal AE that is characterized by an increased amount of high density lipoprotein EB 10020061 high density lipoprotein increased AE a high density lipoprotein abnormal AE that is characterized by a decreased amount of high density lipoprotein EB 10020060 high density lipoprotein decreased AE HPO: HP_0003233 SIDER: C0151691 a lipid analysis result abnormal AE that is characterized by an abnormal amount of low density lipoprotein EB 10024901 low density lipoprotein abnormal AE a low density lipoprotein abnormal AE that is characterized by an increased amount of low density lipoprotein EB 10024910 low density lipoprotein increased AE HPO: HP_0003141 SIDER: C0549399 a low density lipoprotein abnormal AE that is characterized by a decreased amount of low density lipoprotein EB 10024909 low density lipoprotein decreased AE a lipid analysis result abnormal AE that is characterized by an abnormal amount of triglycerides in the blood EB 10005837 blood triglycerides abnormal AE a blood triglycerides abnormal AE that is characterized by an increased amount of triglycerides in the blood EB 10005839 blood triglycerides increased AE HPO: HP_0002155 SIDER: C0853692 a blood triglycerides abnormal AE that is characterized by a decreased amount of triglycerides in the blood EB 10005838 blood triglycerides decreased AE an investigation result abnormal AE that involves an abnormal result for an immunology and allergy investigation EB 10021505 immunology and allergy investigation result abnormal AE a second degree atrioventricular block AE that the electrical signals are delayed more and more with each heartbeat, until the heart skips a beat. On the EKG, the delay is shown as a line (called the PR interval) between the P and QRS waves. The line gets longer and longer until the QRS waves don't follow the next P wave. MedDRA: 10050797 is a LLT for type I second degree atrioventricular block MedDRA (LLT): 10047909 exists for Wenckebach phenomeono MedDRA (LLT): 10047908 exists for Wenchebach MedDRA (LLT): 10027787 for Mobit type I SS, MW, YH Mobitz type 1 block Wenckebach Phenomenon Wenckebach's block type 1 second degree atrioventricular block type I second degree atrioventricular block WEB: https://www.nhlbi.nih.gov/health/health-topics/topics/hb/types 10027787 10047908 10047909 10050797 Mobitz type I block AE CTCAE: E10146 NCIt: C62017 an immunology and allergy investigation result abnormal AE that is characterized by antibodies for epstein barr virus being detected EB 10056906 Epstein-Barr virus antibody positive AE an immunology and allergy investigations result abnormal AE that is characterized by an abnormal microbiology and serology investigation EB 10027529 microbiology and serology investigation result abnormal AE a microbiology and serology investigation result abnormal AE that is characterized by a positive CSF culture EB 10011529 CSF culture positive AE an investigation result abnormal AE that involves an abnormal result of a metabolic and nutritional investigation EB 10027432 metabolic and nutritional investigation result abnormal AE a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal glycosylated hemoglobin level EB 10055587 glycosylated hemoglobin level abnormal AE a glycosylated hemoglobin level abnormal AE that is charaterized by an increased glycosylated hemoglobin level EB 10055587 glycosylated hemoglobin level increased AE This is an AE which is a symptom associated with both non-serious and serious medical issues. a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood folate level EB QY, JX, HY http://en.volupedia.org/wiki/Abdominal_pain 腹挤压伤 10000044 10005525 abdomen crushing AE blood folate level abnormal AE a blood folate abnormal AE that is charaterized by an increased blood folate level EB 10005528 blood folate level increased AE a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood glucose level EB 10005554 blood glucose level abnormal AE a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood homocysteine EB 10049735 blood homocysteine level abnormal AE a blood homocysteine level abnormal AE that is charaterized by a decreased blood homocysteine EB 10049734 blood homocysteine level decreased AE a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood uric acid level EB 10061727 blood uric acid level abnormal AE a blood uric acid level abnormal AE that is characterized by a decreased blood uric acid EB 10005860 blood uric acid level decreased AE a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal vitamin B12 level EB 10062187 vitamin B12 level abnormal AE a vitamin B12 level abnormal AE that is characterized by an increased vitamin B12 level EB 10047610 vitamin B12 level increased AE a vitamin B12 level abnormal AE that is characterized by a decreased vitamin B12 level EB 10047608 vitamin B12 level decreased AE a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal brain natriuretic peptide level EB 10053408 brain natriuretic peptide level abnormal AE a brain natriuretic peptide level abnormal AE that is characterized by an increased brain natriuretic peptide level EB 10053405 brain natriuretic peptide level increased AE a brain natriuretic peptide level abnormal AE that is characterized by a decreased brain natriuretic peptide level EB 10053407 brain natriuretic peptide level decreased AE a hematology investigation result abnormal AE that involves an abnormal result of the oxygen and carbon dioxide content of arterial blood, measured by various methods to assess the adequacy of ventilation and oxygenation and the acid-base status of the body EB, SJ WEB: http://medical-dictionary.thefreedictionary.com/arterial+blood+gas WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003855.htm 10005539 10027432 blood gases abnormal AE may be a result of lung, kidney, or metablolic diseases or the result of abnormal breathing after a head or neck injur blood gas investigation result abnormal AE a blood gas investigation result abnormal AE that is characterized by an abnormal amount of carbon dioxide in the blood EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003469.htm 10064156 carbon dioxide abnormal AE a carbon dioxide abnormal AE that is characterized by an increased carbon dioxide level in the blood EB 10007225 carbon dioxide increased AE HPO: HP_0005972 SIDER: C0860713 a blood gas investigation result abnormal AE that is characterized by an abnormal acidity or alkalinity of blood EB WEB: http://www.medterms.com/script/main/art.asp?articlekey=10001 10005705 blood pH abnormal AE a blood pH abnormal AE that is characterized by an increased blood pH EB 10005708 blood pH increased AE This is an AE which is the protrusion of contents of the abdomen through a defect or weakness in the abdominal wall. a blood pH abnormal AE that is characterized by a decreased blood pH EB QY, JX, HY http://en.volupedia.org/wiki/Eventration 疝腹脏突出 10005706 10057391 blood pH decreased AE hernial eventration AE an adverse event causality evidence that comes from the combined evidence sources YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. adverse event causality evidence from combined sources a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen saturation in the blood EB 10033317 oxygen saturation abnormal AE an oxygen saturation abnormal AE that is characterized by an increased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen EB 10033320 oxygen saturation increased AE a blood gas investigation result abnormal AE that is characterized by an abnormal carbon dioxide partial pressure or tension in the blood EB WEB: http://medical-dictionary.thefreedictionary.com/PCO2 10058982 PCO2 abnormal AE a PCO2 abnormal AE that is characterized by an increased carbon dioxide partial pressure or tension in the blood EB 10034183 PCO2 increased AE a pPCO2 abnormal AE that is characterized by a decreased carbon dioxide partial pressure or tension in the blood EB 10034181 PCO2 decreased AE This is an AE which is most commonly caused by abdominal surgical procedures and the adhesions start to form within hours of surgery and may cause internal organs to attach to other organs in the abdominal cavity. a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen partial pressure in the blood EB QY, JX, HY WEB: http://medical-dictionary.thefreedictionary.com/PO2 http://en.volupedia.org/wiki/Adhesion_(medicine)#Abdominal_adhesions 腹部粘连 10000050 10062087 PO2 abnormal AE abdominal adhesions AE a PO2 abnormal AE that is characterized by an increased oxygen partial pressure in the blood EB 10035769 PO2 increased AE a PO2 abnormal AE that is characterized by a decreased oxygen partial pressure in the blood EB 10035768 PO2 decreased AE an investigation result abnormal AE that results from an abnormal toxicology screen EB 10044260 toxicology drug screen result abnormal AE a toxicology drug screen result abnormal AE that is characterized by positive barbiturates EB 10063230 barbiturates positive AE a toxicology drug screen result abnormal AE that is characterized by positive cocaine EB 10063230 cocaine positive AE a second degree atrioventricular block AE that some of the electrical signals don't reach the ventricles. However, the pattern is less regular than it is in Mobitz type I. Some signals move between the atria and ventricles normally, while others are blocked. On an EKG, the QRS wave follows the P wave at a normal speed. Sometimes, though, the QRS wave is missing (when a signal is blocked). SS, YH, MW Mobitz (type) II atrioventricular block AE Mobitz type 2 block type 2 second degree atrioventricular block type II second degree atrioventricular block WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html 10027786 10050798 Mobitz type II block AE CTCAE: E10140 NCIt: C62018 a toxicology drug screen result abnormal AE that is characterized by increased urine cannabinoids EB 10062228 urine cannabinoids increased AE an investigation result abnormal AE that involves an abnormal result of a neurological, special senses and psychiatric investigation EB neurological, special senses and psychiatric investigation result abnormal AE 10029295 behavioral and neurological test abnormal AE an investigation result abnormal AE resulting from an abnormal physical examination finding EB 10062078 10071940 physical examination result abnormal AE an investigation result abnormal AE that involves an abnormal result of an investigation related to chromosomal abnormalities and pathologic conditions EB WEB: http://medical-dictionary.thefreedictionary.com/Cytogenetic+analysis 10011822 cytogenetic investigation result abnormal AE an investigation result abnormal AE that involves an abnormal respiratory and pulmonary investigation EB 10038668 respiratory and pulmonary investigation result abnormal AE an investigation result abnormal AE that involves an abnormal result of an endocrine investigation EB 10014706 endocrine investigation result abnormal AE an adverse event causality evidence that comes from a randomized controlled clincal trial where a medical intervention is conducted in a random fashion In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30. adverse event causality evidence from randomized clinical trial an endocrine investigation result abnormal AE that is characterized by an abnormal blood parathyroid hormone level EB 10005700 blood parathyroid hormone level abnormal AE a blood parathyroid hormone level abnormal AE that is characterized by an increased blood parathyroid hormone level EB 10005703 blood parathyroid hormone increased AE an endocrine investigation result abnormal AE that is characterized by an abnormal tri-iodothyronine level EB 10044592 tri-iodothyronine level abnormal AE a tri-iodothyronine level abnormal AE that is characterized by an increased tri-iodothyronine level EB 10044596 tri-iodothyronine increased AE an investigation result abnormal AE that involves an abnormal protein and chemistry analysis result EB 10037000 protein and chemistry analysis result abnormal AE a protein and chemistry analysis result abnormal AE that is characterized by an abnormal blood albumin level EB 10005286 blood albumin level abnormal AE a blood albumin level abnormal AE that is characterized by an increased blood albumin level EB 10005288 blood albumin level increased AE a protein and chemistry analysis result abnormal AE that is characterized by an abnormal c-reactive protein level EB 10068559 c-reactive protein level abnormal AE a c-reactive protein level abnormal AE that is characterized by a decreased c-reactive protein level EB 10049220 c-reactive protein level decreased AE This is an AE which occurs when the abdomen becomes subject to increased pressure reaching past the point of intra-abdominal hypertension (IAH). a protein total abnormal AE that is characterized by an increased protein total EB QY, JX, HY http://en.volupedia.org/wiki/Abdominal_compartment_syndrome 腹腔间室综合征 10037016 10058808 abdominal compartment syndrome AE protein total increased AE a protein total abnormal AE that is characterized by a decreased protein total EB 10037014 protein total decreased AE a cardiac and vascular investigation result abnormal AE that involves an abnormal result from a test using a radioactive tracer (called a radionuclide) and a special camera to take pictures of your heart as it pumps blood EB WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Radionuclide-Ventriculography-or-Radionuclide-Angiography-MUGA-Scan_UCM_446354_Article.jsp 10028146 MUGA scan result abnormal AE a cardiac function test abnormal AE that shows an abnormal result on a cardiac stress test. EB, YH WEB: http://medical-dictionary.thefreedictionary.com/Stress+Test WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures 10055014 cardiac stress test result abnormal AE an investigation result abnormal AE that is characterized by an abnormal result of an enzyme investigation EB 10014938 enzyme investigation result abnormal AE a blood creatine phosphokinase level abnormal AE that is characterized by a decreased blood creatine phosphokinase EB 10067760 blood creatine phosphokinase level decreased AE an investigation result abnormal AE that is characterized by an abnormal result of a hematology investigation EB MedDRA: 10057755 haematology investigation abnormal AE 10018851 hematology investigation result abnormal AE a hematology investigation result abnormal AE that results in an abnormal red blood cell profile EB 20000029 red blood cell profile abnormal AE a hematology investigation result abnormal AE that is characterized by an abnormal white blood cell profile EB 20000030 white blood cell profile abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal percentage of neutrophils EB 10058134 neutrophil percentage abnormal AE a neutrophil percentage abnormal AE that is characterized by a decreased percentage of neutrophils EB 10052223 neutrophil percentage decreased AE a white blood cell profile abnormal AE that is characterized by an abnormal basophil count EB 10060978 basophil count abnormal AE a basophil count abnormal AE that is characterized by a decreased basophil count EB 10004167 basophil count decreased AE a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil percentage EB 10058133 eosinophil percentage abnormal AE an eosinophil percentage abnormal AE that is characterized by a decreased eosinophil percentage EB 10052221 eosinophil percentage decreased AE a white blood cell profile abnormal AE that is characterized by an abnormal leukocyte cell number EB leukocyte cell number abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal granulocyte count EB 10018678 granulocyte count abnormal AE a granulocyte count abnormal AE that is characterized by an increased granulocyte count EB 10018683 granulocyte count increased AE a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte cell number EB 10025252 lymphocyte count abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte percentage EB lymphocyte percentage abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal monocyte percentage EB 10067238 monocyte percentage abnormal AE This is an AE which is the abnormal exit of tissue or an organ, such as the bowel, through the wall of the cavity in which it normally resides. a monoctyte percentage abnormal AE that is characterized by a decreased monocyte percentage EB QY, JX, HY http://en.volupedia.org/wiki/Hernia#Individual_hernias 腹疝 10052229 10060954 abdominal hernia AE monocyte percentage decreased AE an enzyme investigation result abnormal AE that is characterized by an abnormal blood lactate dehydrogenase level EB 10005627 blood lactate dehydrogenase level abnormal AE a blood lactate dehydrogenase level abnormal AE that is characterized by a decreased blood lactate dehydrogenase EB 10005629 blood lactate dehydrogenase level decreased AE an enzyme investigation result abnormal AE that is characterized by an abnormal troponin level EB troponin level abnormal AE an enzyme investigation result abnormal AE that is characterized by an abnormal muscle enzyme level EB muscle enzyme level abnormal AE a muscle enzyme level abnormal AE that is characterized by a decreased muscle enzyme level EB 10057952 muscle enzyme level decreased AE an enzyme investigation result abnormal AE that is characterized by an abnormal myoglobin level in the blood EB myoglobin blood abnormal AE a myoglobin blood abnormal AE that is characterized by an increased myoglobin level in the blood EB 10028625 myoglobin blood increased AE a myoglobin blood abnormal AE that is characterized by a decreased myoglobin level in the blood 10059940 myoglobin blood decreased AE an investigation result abnormal AE that is characterized by an abnormal result of a gastrointestinal investigation EB 10017971 gastrointestinal investigation result abnormal AE a gastrointestinal investigation result abnormal AE that is characterized by an abnormal blood amylase level EB 10054822 blood amylase level abnormal AE a blood amylase level abnormal AE that is characterized by a decreased blood amylase level EB 10005327 blood amylase level decreased AE a gastrointestinal investigation result abnormal AE that is characterized by an abnormal lipase level EB 10054821 lipase level abnormal AE a lipase level abnormal AE that is characterized by an increased lipase level EB 10024574 lipase level increased AE a lipase level abnormal AE that is characterized by a decreased lipase level EB 10024573 lipase level decreased AE an investigation result abnormal AE that is characterized by an abnormal liver related investigation result EB 20000008 liver related investigation result abnormal AE a liver related investigation result abnormal AE that is characterized by an abnormal level of transaminases EB 10062688 transaminase level abnormal AE a transaminase level abnormal AE that is characterized by a decreased level of transaminases EB 10054795 transaminase level decreased AE a liver related investigation result abnormal AE that is characterized by an abnormal aspartate aminotransferase level EB 10003477 aspartate aminotransferase level abnormal AE an aspartate aminotransferase level abnormal AE that is characterized by a decreased aspartate aminotransferase level EB 10003479 aspartate aminotransferase level decreased AE a gamma-glutamyltransferase level abnormal AE that is characterized by a decreased gamma-glutamyltransferase level EB 10017690 gamma-glutamyltransferase level decreased AE a blood bilirubin level abnormal AE that is characterized by a decreased blood bilirubin level EB 10049869 blood bilirubin level decreased AE an investigation result abnormal AE that is characterized by an abnormal result of an imaging investigation EB 10022893 imaging investigation result abnormal AE a hematology investigation result abnormal AE that is characterized by an abnormal blood thromboplastin level EB 10005824 blood thromboplastin level abnormal AE a blood thromboplastin level abnormal AE that is characterized by a decreased blood thromboplastin level EB 10005826 blood thromboplastin level decreased AE a hematology investigations result abnormal AE that is characterized by an abnormal coagulation factor v level EB 10061771 coagulation factor v level abnormal AE a coagulation factor v level abnormal AE that is characterized by an increased coagulation factor v level EB 10009756 coagulation factor v level increased AE a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin level EB 10037048 prothrombin level abnormal AE a prothrombin level abnormal AE that is characterized by an increased prothrombin level EB 10037051 prothrombin level increased AE HPO: HP_0003645 SIDER: C0151872 a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin time EB 10037057 prothrombin time abnormal AE a prothrombin time abnormal AE that is characterized by a shortened prothrombin time EB 10037070 prothrombin time shortened AE a full blood count abnormal AE that is characterized by an increased full blood count EB 10052239 full blood count increased AE a red blood cell profile abnormal AE that is characterized by an abnormal red blood cell count EB 10038151 red blood cell count abnormal AE a red blood cell count abnormal AE that is characterized by an increased red blood cell count EB 10038155 red blood cell count increased AE a red blood cell profile abnormal AE that is characterized by an abnormal hematocrit EB 10057763 hematocrit abnormal AE a hematocrit abnormal AE that is characterized by an increased hematocrit EB 10019424 hematocrit increased AE a hemoglobin level abnormal AE that is characterized by an increased hemoglobin level EB 10055599 hemoglobin level increased AE CTCAE: E12171 NCIt: C78333 a red blood cell profile abnormal AE that is characterized by an abnormal mean corpuscular volume EB 10027009 mean corpuscular volume abnormal AE a mean corpuscular volume abnormal AE that is characterized by an increased mean corpuscular volume EB 10051859 mean corpuscular volume increased AE a mean corpuscular volume abnormal AE that is characterized by a decreased mean corpuscular volume EB 10051858 mean corpuscular volume decreased AE a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin level EB mean cell hemoglobin level abnormal AE a mean cell hemoglobin level abnormal AE that is characterized by an increased mean cell hemoglobin level EB 10055622 mean cell hemoglobin level increased AE a mean cell hemoglobin level abnormal AE that is characterized by a decreased mean cell hemoglobin level EB 10055621 mean cell hemoglobin level decreased AE a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin concentration EB 10067730 mean cell hemoglobin concentration abnormal AE a mean cell hemoglobin concentration abnormal AE that is characterized by an increased mean cell hemoglobin concentration EB 10026992 mean cell hemoglobin concentration increased AE a mean cell hemoglobin concentration abnormal AE that is characterized by a decreased mean cell hemoglobin concentration EB 10026991 mean cell hemoglobin concentration decreased AE a conduction system disorder that refers to abnormalities in SN impulse formation and propagation and includes sinus bradycardia, sinus pause/arrest, chronotropic incompetence, and sinoatrial exit block. SS SND sinus node dysfunction WEB: http://emedicine.medscape.com/article/158064-overview sinoatrial node dysfunction AE a coronary artery disorder AE that takes place in or is related to the coronary inside the heart Even though 'coronary disorder AE' seems to be a more general term of 'coronary artery disorder AE' that should place 'coronary disorder AE' as a parent of 'coronary artery disorder AE', KB's comment from clinical perspective is that these two terms are synonymous in practice, and coronary disorder almost always means coronary artery disorder. If 'coronary disorder AE' gets picked up from reports, it is a generalized term of 'coronary artery disorder AE'; and thereofore, we created a place holder for this term under 'coronary artery disorder AE' SS coronary disorder AE a myocardial infarction AE in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery. SS myocardial infarction, inferior wall AE WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=inferior+wall+myocardial+infarction inferior wall myocardial infarction AE a myocardial infarction AE in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction. SS myocardial infarction, anterior wall AE WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=anterior+wall+myocardial+infarction anterior wall myocardial infarction AE a hematology investigation result abnormal AE that is characterized by an abnormal blast cell count EB blast cell count abnormal AE a blast cell count abnormal AE that is characterized by a decreased blast cell count EB 10062275 blast cell count decreased AE a hematology investigation result abnormal AE that is characterized by an abnormal platelet count EB 10035526 platelet count abnormal AE HPO: HP_0011873 SIDER: C0580317 a platelet count abnormal AE that is characterized by an increased platelet count SZ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/thrombocytosis 10051608 platelet count increased AE a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil count EB 10061125 eosinophil count abnormal AE an eosinophil count abnormal AE that is characterized by a decreased eosinophil count EB 10014943 eosinophil count decreased AE a hypertension AE that is characterized by high blood pressure in the systemic arteries - the vessels that carry blood from the heart to the body's tissues (other than the lungs). SS WEB: http://www.pted.org/?id=syshypertension1 systemic hypertension AE a hypotension AE that has an outcome of a decrease in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body SS WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes 10005758 blood pressure systolic decreased AE HPO: HP_0006673 SIDER: C0277885 a cardiac valve disease AE that is characterized by an impaired function of a papillary muscle, usually due to ischemia or infarction, with resulting incompetence of the mitral (rarely tricuspid) valve. SS papillary muscle dysfunction papillary muscle syndrome WEB: http://medical-dictionary.thefreedictionary.com/papillary+muscle+dysfunction 10061330 papillary muscle disorder AE a hypertension AE that has an outcome of an increase in the amount of pressure in the arteries when the heart is at rest between beats SS WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers 10005739 blood pressure diastolic increased AE HPO: HP_0005117 SIDER: C0277889 a hypertension AE that has an outcome of an increase in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body SS WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers 10005760 blood pressure systolic increased AE HPO: HP_0004421 SIDER: C0277884 a cardiac ventricular disorder AE that is a condition in nwhich the right ventricle of the heart was functionally impaired. This condition usually leads to heart failure or myocardial infarction, and other cardiovascular complicationns. SS WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=right%20ventricular%20dysfunction 10058597 right ventricular dysfunction AE CTCAE: E10196 NCIt: C50733 an arrhythmia AE that is characterized by a premature contraction of the ventricle SS infranodal extrasystoles AE WEB: http://dictionary.reference.com/browse/ventricular+extrasystole 10047289 ventricular extrasystoles AE HPO: HP_0006696 SIDER: C0151636 an embolism disorder AE that is a result of an obstruction in a cardiac vessel due to a blood clot or other foreign matters SS heart embolism AE WEB: http://medical-dictionary.thefreedictionary.com/Heart+embolism cardiac embolism AE a vascular disorder AE that is characterized by an obstruction in a blood vessel due to a blood clot or other foreign matter that gets stuck while traveling through the bloodstream. SS WEB: http://medical-dictionary.thefreedictionary.com/embolism 栓塞 10014523 embolism AE HPO: HP_0001907 SIDER: C0013922 an adverse event causity that represents a retrodictrive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: given an individual who has received a medical intervention and developed the adverse event, was the event caused by the medical intervention? YH retrodictive causality of adverse event Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20. retrodictive AE causality an arrhythmia AE that results in extra, abnormal heartbeats that begin in one of the heart's two lower pumping chambers (ventricles). These extra beats disrupt the regular heart rhythm, sometimes causing the patient to feel a flip-flop or skipped beat in the chest. SS PVCs WEB: http://www.mayoclinic.com/health/premature-ventricular-contractions/DS00949 10036614 premature ventricular contractions AE a cardiac valve disease AE that is charaterized by the backflow of blood from the pulmonary artery into the right ventricle, owing to imperfect functioning of the pulmonary valve SS pulmonic incompetence AE WEB: http://www.rightdiagnosis.com/medical/pulmonary_valve_incompetence.htm 10037448 pulmonary valve incompetence AE HPO: HP_0010444 SIDER: C0034088 a cardiac vavle disease AE that is characterized by a congenital heart defect in which blood flow from the heart to the pulmonary artery is blocked SS pulmonic stenosis AE WEB: http://medical-dictionary.thefreedictionary.com/Pulmonary+Valve+Stenosis 10037450 pulmonary valve stenosis AE a vasculitis AE that is an inflammation specific to an artery or arteries SS WEB: http://medical-dictionary.thefreedictionary.com/arteritis 10003230 arteritis AE HPO: HP_0005291 SIDER: C0003860 a process quality that represents the level of severity of an adverse event. YH, SS AE severity severity of adverse event a vascular disorder AE that results in an abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel SS WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001122.htm 10002329 aneurysm AE HPO: HP_0002617 SIDER: C0002940 a vascular disorder that affects the veins or blood circulation of the veins SS venous disorder AE an aneurysm AE that results in the weakening of the balloon-like bulge that the blood pressure causes the artery wall to leak or burst SS SAH ruptured aneurysm AE subarachnoid hemorrhage AE WEB: http://www.mayfieldclinic.com/PE-AneurRupt.htm#.Uor4tI3QHh0 10048380 aneurysm ruptured AE HPO: HP_0002617 SIDER: C0162869 an aneurysm AE that refers to an aneurysm involving cardiac tissue. This most often occurs as a ventricular aneurysm following a myocardial infarction SS aneurysm of heart AE heart aneurysm AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/19239694 10007513 cardiac aneurysm AE an aneurysm AE that occurs in the aorta SS WEB: http://www.webmd.com/heart-disease/tc/aortic-aneurysm-overview 10002882 aortic aneurysm AE HPO: HP_0004942 SIDER: C0003486 an aneurysm ruptured AE that occurs in the aorta SS ruptured aortic aneurysm AE 10002886 aortic aneurysm rupture AE HPO: HP_0002622 SIDER: C0741160 an aortic disorder AE in which there is a separation of the aorta walls. The small tear can become larger. It can lead to bleeding into and along the wall of the aorta, the major artery carrying blood out of the heart. SS WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000181.htm 10002895 aortic dissection AE HPO: HP_0004933 SIDER: C0340643 an aneurysm ruptured AE that occurs in the brain where blood spurts into the subarachnoid space under arterial pressure, continuing until increased local or generalized intracranial pressure stops the bleeding. SS WEB: http://ether.stanford.edu/library/neuroanesthesia/Journal%20Articles/Ruptured%20cerebral%20aneurysms.pdf WEB: http://www.ncbi.nlm.nih.gov/pubmed/15647574 10039330 ruptured cerebral aneurysm AE an aneurysm AE that occurs in the brain SS brain aneurysm AE cerebral aneurysm AE intracerebral aneurysm AE WEB: http://www.ninds.nih.gov/disorders/cerebral_aneurysm/detail_cerebral_aneurysms.htm 10022758 intracranial aneurysm AE HPO: HP_0004944 SIDER: C0007766 a thrombosis AE that is a rare lesion and may be defined as a thrombosis of a vessel without any obvious underlying cause that occurs in the aorta SS WEB: http://circ.ahajournals.org/content/17/5/941.full.pdf 10002910 aortic thrombosis AE an arterial thrombosis AE that is characterized by the occurrence of a thrombus in the carotid arteries (two large blood vessels that supply oxygenated blood to the large, front part of the brain) SS WEB: http://www.webmd.com/heart-disease/carotid-artery-disease-causes-symptoms-tests-and-treatment 10007688 carotid artery thrombosis AE an arterial embolism AE that occurs in the cerebral artery SS cerebral embolism AE embolic stroke AE thrombotic stroke AE WEB: http://medical-dictionary.thefreedictionary.com/cerebral+embolism 10008088 10014498 10043647 cerebral artery embolism AE an arterial thrombosis AE that occurs in the cerebral artery, also referred to as an embolism AE [SS] Per DRA and KKB's comment, this term may also be characterized as a type of embolism even though labeled thrombosis. cerebral thrombosis AE 10008092 10008132 cerebral artery thrombosis AE a venous thrombosis AE that is characterized by thrombosis of the venous channels in the brain. It is an uncommon cause of cerebral infarction relative to arterial disease, but it is an important consideration because of its potential morbidity. [SS] From http://medical-dictionary.thefreedictionary.com/cerebral+venous+thrombosis, Merwarth syndrome - progressive hemiplegia due to venous occlusion. Synonym(s): cerebral venous thrombosis SS WEB: http://emedicine.medscape.com/article/1162804-overview 10008138 cerebral venous thrombosis AE a venous thrombosis AE that occurs when a blood clot forms in the brain’s venous sinuses that prevents blood from draining out of the brain. As a result, blood cells may break and leak blood into the brain tissues, forming a hemorrhage. SS CVST WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/cerebral_venous_sinus_thrombosis_134,69/ 10061251 intracranial venous sinus thrombosis AE an embolism AE that is caused by a gas bubble that enters the vein [SS] The term 'gas embolism' is listed as a unique term, and not a superset or a synonym of 'air embolism' due to the different pathology reconized by physicians that air embolism is mostly recognized when an air bubble caused by IV or other injection device enters the vein, while a gas embolism is mostly caused by a gas bubble released as a product of an infection, or other devices such as nitrogen tank. SS gas embolilsm AE a thrombosis that is characterized by a clot that blocks blood flow a mesenteric vein, one of two veins through which blood leaves the intestine. The condition interrupts the blood supply to the intestine and can result in damage to the intestines. [SS] http://emedicine.medscape.com/article/193921-overview, Mesenteric venous thrombosis (also known as visceral venous thrombosis) is a rare but lethal form of mesenteric ischemia (see the image below). Antonio Hodgson first described mesenteric ischemia in the latter part of the 15th century. In 1895, Elliot first described mesenteric venous thrombosis as a cause of mesenteric ischemia. By the turn of the 19th century, many review articles and texts were describing the recent advances in the characterization and treatment of mesenteric ischemia, particularly venous thrombosis. In 1935, Warren and Eberhard reported that intestinal infarction resulted from ischemia due to venous thrombosis, and they reported a mortality rate of 34% in patients with venous thrombosis after resection. Unfortunately, despite improvements in therapy, this mortality rate still holds. SS mesenteric venous thrombosis AE visceral venous thrombosis AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001157.htm 10027402 mesenteric vein thrombosis AE a thrombosis AE that is an uncommon condition induced by thrombotic or nonthrombotic obstruction of hepatic venous outflow and characterized by hepatomegaly, ascites, and abdominal pain. SS WEB: http://emedicine.medscape.com/article/184430-overview 10006537 Budd-Chiari syndrome AE a thrombosis AE that occurs in the vein carrying the blood away from the retina [SS] The term 'retinal vein thrombosis' is listed as a different class from 'retinal vein occlusion' for the difference in the pathological process of how the blockage occurs in the vein. SS 10038908 retinal vein thrombosis AE an adverse event causity that represents a predictive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: will the next person who received a medical intervention will develop the adverse event? Or: how frequently will vaccine recipients experience the adverse event as a result of a medical intervention? YH predictive causality of adverse event Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20. predictive AE causality an embolism AE that occurs in the artery. It is a sudden interruption of blood flow to an organ or body part due to a clot (embolus). SS embolism arterial AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001102.htm 10014513 arterial embolism AE a thrombosis AE* that is a result of when a blood vessel is obstructed by a blood clot (embolus) that has been carried in the bloodstream from the site of its formation. Thromboembolic disease includes both venous thromboembolism (VTE) and arterial thrombosis. VTE is an general term which refers to mainly two conditions: deep vein thrombosis (DVT) and its potentially fatal acute complication, pulmonary embolism (PE). Arterial embolism is a frequent complication in patients with atrial fibrillation (AF) and can lead to stroke or systemic embolism. * see editor note [SS] Per DRA and KKB's comment, this term is synonymous to venous thrombosis even though labeled embolism. Cross-reference is made via seeAlso. SS VTE embolism venous AE venous thromboembolism AE WEB: http://www.boehringer-ingelheim.com/products/prescription_medicines/thromboembolic_diseases.html 10014522 venous embolism AE OAE: 0001505 an embolism AE that is characterized by the obstruction of blood vessel by fat droplets SS WEB: http://emedicine.medscape.com/article/460524-overview#showall 10016246 fat embolism AE a embolism AE that is infected with bacteria containing pus SS septic embolism AE WEB: http://www.medicalnewstoday.com/articles/153704.php 10040067 septic embolus AE a thrombosis AE that occurs in or may be caused by an implanted device in the body SS 10062546 thrombosis in device AE a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion SS TMA WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583 10043645 This term is obsolete since there is another term with the same name already. Oliver obsolete: thrombotic microangiopathy AE an arterial thrombosis AE that occurs in the limb(s) of the body SS 10003180 arterial thrombosis limb AE an inflammation AE that occurs in eye. YH, JX eye inflammation AE SS 10022104 injection site thrombosis AE a deep vein thrombosis AE that occurs in the pelvis. Ovarian vein thrombosis arises out of the coincident conditions of venous stasis and hypercoagulability, which are commonly present in the recently postpartum patient. SS ovarian vein thrombosis AE WEB: http://emedicine.medscape.com/article/404364-overview 10034272 pelvic venous thrombosis AE an embolism AE that is charaterized by a sudden blockage in a lung artery. The blockage usually is caused by a blood clot that travels to the lung from a vein in the leg. SS PE WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/pe/ 10061340 peripheral embolism AE a thrombosis AE that occurs in subclavian vein. Among patients with effort-induced thrombosis with subclavian vein stenosis, the thrombosis occurs in the dominant arm in 80% of cases. SS WEB: http://emedicine.medscape.com/article/424777-overview#showall 10049446 subclavian vein thrombosis AE a thrombophlebitis AE that is characterized by an inflammation of a vein due to a blood clot in a vein located just below the skin's surface. YH: MedDRA: 10043595 is for "thrombophlebitis superficial"; MedDRA: 10042554 is for "superficial thrombophlebitis" SS, YH, MW thrombophlebitis superficial AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000199.htm 表在性血栓性静脈炎 superficial thrombophlebitis AE CTCAE: E13817 NCIt: C78634 UMLS CUI: C1510431 SS 10061408 venous thrombosis limb AE a thrombosis that is characterized by a blockage of the small veins that carry blood away from the retina. The retina is the layer of tissue at the back of the inner eye that converts light images to nerve signals and sends them to the brain. SS RVO WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007330.htm 10038907 retinal vein occlusion AE a thrombosis AE that occurs in the atrium (left or right) SS WEB: http://ehjcimaging.oxfordjournals.org/content/9/1/204.full 10048632 atrial thrombosis AE an arterial thrombosis AE that occurs in the coronary artery SS coronary embolism AE WEB: http://medical-dictionary.thefreedictionary.com/Coronary+embolism 10011084 10011091 coronary artery thrombosis AE a sleep apnea AE is a sleep disorder AE in which breathing repeatedly stops and starts. Basically, it is a crossproduct of sleep disorder AE and apnea AE. MW, YH WEB: http://www.mayoclinic.org/diseases-conditions/sleep-apnea/basics/definition/con-20020286 10040975 sleep apnea AE CTCAE: E13566 NCIt: C26884 a brain AE that occurs when flow of oxygen-rich blood to a portion of the brain is blocked JX, LW, YH cardiovascular accident AE WEB: http://en.wikipedia.org/wiki/Stroke WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/stroke/ 中风 10042244 stroke AE CTCAE: E12826 NCIt: C3390 a stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain. SS ischaemic stroke AE WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ 10061256 ischemic stroke AE a stroke AE that occurs when a blood vessel that supplies the brain ruptures and bleeds causing the deficiency of oxygen and nutrients to brain cells and tissues SS haemorrhagic stroke AE WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ 10019016 hemorrhagic stroke AE a haemorrhagic stroke AE that is cuased by hypertension (high blood pressure), and bleeding occurs suddenly and rapidly. SS intracerebral haemorrhagic stroke AE WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ intracerebral hemorrhagic stroke AE a haemorrhagic stroke AE that is cuased by the bleeding (haemorrhage) between the brain and the meninges (the membrane that covers the brain) in the subarachnoid space. SS subarachnoid haemorrhagic stroke AE WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ subarachnoid hemorrhagic stroke AE an ischaemic stroke AE that is caused by a thrombus (blood clot) that develops in the arteries supplying blood to the brain SS WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ 10043647 thrombotic stroke AE an ischaemic stroke AE that is caused by an embolus (a blood clot that formms elsewhere in the body and travels through the bloodstream to the brain). SS WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ 10014498 embolic stroke AE a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative. YH, Izabela Birsanescu mental disorder AE WEB: http://en.wikipedia.org/wiki/Mental_disorder 10037175 psychiatric disorder AE a psychiatric disorder AE that has an outcome of a adjustment disorder. An adjustment disorder is an unexpectedly strong emotional or behavioral reaction that occurs in response to an identifiable stressful life event or life change that occurred within the previous three months. Yongqun He, Izabela Birsanescu WEB: http://www.healthline.com/health/adjustment-disorder 10001301 10001302 adjustment disorder AE an adjustment disorder AE that has an additional depressed mood. The person is more depressed than would be expected after a stressful event. Yongqun He, Izabela Birsanescu WEB: http://www.summitmedicalgroup.com/library/adult_health/bha_adjustment_disorder_with_depressed_mood/ 10001297 adjustment disorder with depressed mood AE a hemorrhage AE that has an outcome of bleeding from anastomosis site. Anastomosis: pathological formation of an opening between two normally distinct spaces or organs. Yongqun He, Izabela Birsanescu WEB: http://medical-dictionary.thefreedictionary.com/anastomosis 10071781 anastomotic bleeding AE a clostridial infection AE that is caused by C. difficule. Yongqun He, Izabela Birsanescu WEB: http://www.mayoclinic.org/diseases-conditions/c-difficile/basics/definition/CON-20029664?p=1 10054236 Clostridium difficile infection AE Yongqun He, Izabela Birsanescu a bacteraemia AE that is more specifically associated with a Gram-negative bacterium. 10054228 Gram-negative bacteremia AE a physical quality that a drug level inside a host increases Yongqun He, Izabela Birsanescu drug level increase a quality that represents the level of critical or lethal reaction to an erroneous dosage of a drug medication. Yognqun He, Izabela Birsanescu WEB: http://medical-dictionary.thefreedictionary.com/drug+toxicity Drug toxicity may occur due to human error or intentional overdose in the case of suicide or homicide. drug toxicity a hemorrhage AE that has an outcome of massive amounts of blood loss. A typical Intraoperative hemorrhage has a blood loss exceeding 1000 mL or requires a blood transfusion Yongqun He, Izabela Birsanescu WEB: http://www.uptodate.com/contents/management-of-hemorrhage-in-gynecologic-surgery 10055298 Intraoperative hemorrhage AE CTCAE: E11810 NCIt: C35135 an abscess AE that shows a cavity of pus within the pancreas Yongqun He, Izabela Birsanescu WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000270.htm 10048984 pancreatic abscess AE a sugery AE that has an adverse outcome where the recipient’s body rejects the pancreas transplantation. Yongqun He, Izabela Birsanescu WEB: http://www.medscape.com/viewarticle/436542_13 10049169 pancreas transplant rejection AE an infection AE that has an outcome of a severe local inflammation, usually with pus formation, generally caused by one of the pyogenic bacteria. Yongqun He, Izabela Birsanescu WEB: http://www.medilexicon.com/medicaldictionary.php?t=44396 10021861 pyogenic infection AE a fever AE that has unknown origin. Yongqun He, Izabela Birsanescu WEB: http://medicine.academic.ru/123590/fever_of_unknown_origin 10016563 fever of unknown origin AE a temporal interval that starts at the time a medical intervention occurs and ends at the time when the initial bodily process occurs. Yongqun He time interval for initial process after medical intervention a temporal interval that starts at the time in the end of the initial process and ends at the time when the final process leading to an adverse event clinical outcome occurs. Yongqun He time interval for intermediate causal AE process a temporal interval that covers the time period of the final process leading to the display of clinical outcome. Yongqun He time interval for AE process showing clinical outcome a pathological bodily process that starts to occur after a medical intervention. Yongqun He initial stage causal AE sub-process a pathological bodily process that occurs in the middle of the causal adverse event process, i.e., after the initial causal AE process and before the last AE process that results in the adverse outcome. Yongqun He intermediate stage causal AE sub-process a pathological bodily process that occurs in the last stage of adverse event and results in the adverse clinical outcome. This clinical outcome may come as a result of causal adverse event (caused by the medical intervention), or result from an unrelevant cause (i.e., not the designated medical intervention). Yongqun He AE process showing pathological clinical outcome late stage AE formation sub-process a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event ends. The adverse event ends when the patient recovers from the adverse event or dies due to the severity of the adverse event. Yongqun He adverse event time period an organism that has the role of 'patient role'. Yongqun He patient an adverse event tme period whent the adverse event is causal adverse event. Yongqun He time interval for causal AE a causality of AE based on the Naranjo ADR probability scale method. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html causality based on Naranjo ADR probability scale a Naranjo ADR probability scale that shows definite causality result. It happens when the score is >=9. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Definite Naranjo ADR probability a Naranjo ADR probability scale that shows probable causality result. It happens when the score is 5-8. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Probably Naranjo ADR probability a Naranjo ADR probability scale that shows possible causality result. It happens when the score is 1-4. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Possible Naranjo ADR probability a Naranjo ADR probability scale that shows doubtful causality result. It happens when the score is <=0. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Doubtful Naranjo ADR probability a causality of AE that is based on the Clinical Data Interchange Consortium (CDISC) system Yongqun He causality based on the Clinical Data Interchange Consortium (CDISC) system Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf AE causality based on CDISC system an AE causality based on CDISC system that has the scale "Not Related". Yongqun He Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf Not Related AE causality based on CDISC system an AE causality based on CDISC system that has the scale "Possibly Related". Yongqun He Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf Possibly Related AE causality based on CDISC system an AE causality based on CDISC system that has the scale "Unlikely Related". Yongqun He Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf Unlikely Related AE causality based on CDISC system an AE causality based on CDISC system that has the scale "Definitely Related". Yongqun He Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf Definitely Related AE causality based on CDISC system an AE causality based on CDISC system that has the scale "Probably Related". Yongqun He Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf Probably Related AE causality based on CDISC system an AE causality that is based on the Drug Interaction Probability Scale (DIPS). Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. causality based on DIPS score a causality based on DIPS score that is "Highly Probable". It occurs when the sore is >8. Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Highly Probable causality based on DIPS score a causality based on DIPS score that is "Probable". It occurs when the sore is 5-8. Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Probable causality based on DIPS score a causality based on DIPS score that is "Possible". It occurs when the sore is 2-4. Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Possible causality based on DIPS score a causality based on DIPS score that is "Doubtful". It occurs when the sore is <2. Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Doubtful causality based on DIPS score a severity of AE that shows sign and symptom within normal limits. YH, SS AE severity Grade 0 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_0_Adverse_Event Note the AE severity Grade 0 equals to CTCAE G0 AE severity. AE severity G0 CTCAE4: E10004 (Grade 0 Adverse Event) a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated. YH, SS AE severity Grade 1 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event Note the AE severity Grade 1 equals to CTCAE G1 AE severity. AE severity G1 CTCAE4: E10005 (Grade 1 Adverse Event) a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances). YH, SS AE severity Grade 2 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event Note the AE severity Grade 2 equals to CTCAE G2 AE severity. AE severity G2 CTCAE4: E10006 (Grade 2 Adverse Event) a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). YH, SS AE severity Grade 3 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event Note the AE severity Grade 3 equals to CTCAE G3 AE severity. AE severity G3 CTCAE4: E10007 (Grade 3 Adverse Event) a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral). YH, SS AE severity Grade 4 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event Note the AE severity Grade 4 equals to CTCAE G4 AE severity. AE severity G4 CTCAE4: E10008 (Grade 4 Adverse Event) a severity of AE that results in death. YH, SS AE severity Grade 5 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event Note the AE severity Grade 5 equals to CTCAE G5 AE severity. AE severity G5 CTCAE4: E10009 (Grade 5 Adverse Event) a blood phosphate abnormal AE that has an abnormally increased amount of phosphate in the blood EB, YH, MW WEB: https://en.wikipedia.org/wiki/Hyperphosphatemia 10020712 hyperphosphatemia AE HPO: HP_0002905 a clincal laboratory test that performs a medical examination using X-ray, a type of electromagnetic radiation. Rebecca Racz, Yongqun He WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003337.htm X-ray clinical test a respiratory distress AE that is characterized by insufficient oxygen flow in the heart and respiratory system. SS, YH WEB: http://medicalcenter.osu.edu/patientcare/healthcare_services/lung_diseases/about/signs/Pages/index.aspx, http://www.merriam-webster.com/dictionary/cardiorespiratory 10049874 cardio-respiratory distress AE A joint disorder AE that has the presence of increased intra-articular fluid. It can be caused by trauma, arthritis, or gout and often affects the knee. RR, YH, MW PMID: 19915432 WEB: http://en.wikipedia.org/wiki/Joint_effusion 10023215 joint effusion AE CTCAE:E12431 NCIt:C49052 a gastrointestinal disorder AE that shows a problem with the stomach, ranging from indigestion and heartburn to peptic ulcers and GERD. RR, YH stomach disorder AE WEB: http://www.nlm.nih.gov/medlineplus/stomachdisorders.html 10056819 gastric disorder AE A medical intervention that involves the replacement of bodily fluids excessively lost. Fluids may be replaced orally or intravenously. RR, YH fluid resuscitation WEB: http://www.mayoclinic.org/diseases-conditions/dehydration/basics/treatment/con-20030056 10061858 fluid replacement An inflammation AE that displays an inflammation (not an infection) of the thyroid gland. http://www.endocrineweb.com/conditions/thyroid/thyroiditis yongqun he, liwei wang thyroiditis AE a urinary system AE that has an outcome of the excretion of glucose into the urine. web: http://en.wikipedia.org/wiki/glycosuria LW, YH glucosuria AE an inflammation AE that shows localized nodular inflammation found in tissues. KM, JX, YH WEB: http://en.wikipedia.org/wiki/Granuloma WEB: http://www.mayoclinic.org/granuloma/expert-answers/faq-20057838 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3629 10018691 granuloma AE a burning sensation AE that occurs at the skin. KM, JX, YH 10054786 skin burning sensation AE a sensory capability AE that has an outcome of numbness, a loss of sensation of feeling in a part of the body. YH, JS WEB: http://www.mayoclinic.org/symptoms/numbness/basics/definition/sym-20050938 10029829 numbness AE a pneumonia AE that occurs at the interstitial lung. Interstitial pneumonia is often caused by an infection of bacteria, viruses, or fungii. A bacterium called Mycoplasma pneumonia is the most common cause. JX, YH WEB: http://www.webmd.com/lung/interstitial-lung-disease 10022617 interstitial pneumonia AE a numbness AE that occurs around the mouth. The terms 'circumoral numbness AE' and 'circumoral paresthesia AE' appear to be synonyms. YH, JS WEB: http://link.springer.com/referenceworkentry/10.1007%2F3-540-29623-9_6515 10049339 circumoral numbness AE Skin necrosis AE is a necrosis AE that results in the death of the skin tissue. Skin necrosis often occurs when not enough blood and oxygen are supplied to a given skin region. JX, LW, YH 皮肤坏死 10040893 skin necrosis AE UMLS ID: C0151799 Systemic lupus erythematosus (SLE) syndrome AE is a lupus syndrome AE that is systemic and disseminated. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. Although “lupus” actually includes a number of different diseases, SLE is the most common type of lupus, and when people say “lupus,” they are often referring to SLE. JX, LW, YH SLE systemic lupus erythematosus syndrome AE 系统性红斑狼疮 WEB: http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus WEB: http://www.healthline.com/health/systemic-lupus-erythematosus#Overview1 系统性红斑狼疮综合征 systemic lupus erythematosus AE Urgent urination AE is a urinary system AE that has an outcome of a sudden, compelling urge to urinate, along with discomfort in the bladder. JX, LW, YH micturition urgency urinary urgency WEB: http://sideeffects.embl.de/se/C0085606/ WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003140.htm 尿急 10046593 urgent urination AE CTCAE: E13062 NCIt: C50792 UMLS CUI: C0439609 Precordialgia AE is a pain AE that pain located in the precordial region. JX, LW, YH WEB: http://www.drugs.com/dict/precordialgia.html 心前痛 precordialgia AE Dyshidrosis AE is a skin AE that shows a disorder of eccrine sweat glands, characterized by small blisters on the hands or feet. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Dyshidrosis 汗疱疹 10013912 dyshidrosis AE Ankle swelling AE is an edema AE that shows abnormal buildup of fluid in the ankles. Ankle swelling is a sign of fluid buildup or inflammation of the joint and tissues of the ankle. Mild ankle swelling is a common occurrence after standing for a long period. JX, LW, YH WEB: http://www.healthgrades.com/symptoms/ankle-swelling 踝部水肿 10002554 ankle swelling AE UMLS ID: C0235439 Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia. This term appears to be a synonym to the 'renal failure AE'. JX, LW, YH hepatic and renal function disorder AE 肾功能障碍 renal dysfunction AE UMLS ID: C0859242 Epiphora AE is a eye AE that shows an overflow of tears onto the face. In this case, there is insufficient tear film drainage from the eyes, and the tears will drain down the face rather than through the nasolacrimal system. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Epiphora_(medicine) 泪溢 10015068 epiphora AE UMLS ID: C0152227 Hemolytic anemia AE is an anemia AE associated with hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). Such an AE can be relatively harmless or life-threatening. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hemolytic_anemia 溶血性贫血 10019493 hemolytic anemia AE a behavioral and neurological AE where somniloquy also is called sleep-talking, a parasomnia that refers to talking aloud while asleep. Somniloquy can be quite loud, ranging from simple mumbling sounds to loud shouts and long frequently inarticulate speeches, and can occur many times during a sleep cycle. As with sleepwalking and night terrors, sleeptalking usually occurs during the less-deep delta-wave NREM sleep stages or during temporary arousals therefrom. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Somniloquy 梦呓 somniloquy AE Cholelithiasis AE is a liver, biliary, and pancreatic AE that shows hard deposits forming inside the gallbladder. Gallstones may be as small as a grain of sand or as large as a golf ball. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Gallstone 10008629 cholelithiasis AE UMLS ID: C1328486 Blepharoptosis AE is an eye AE that shows droopy upper eyelid or ptosis that presents with substantial blockage upper part of field of vision, risk of amblyopia among young children, and dramatic change in the facial appearance. JX, LW, YH WEB: http://eyewiki.aao.org/Blepharoptosis 眼睑下垂 10005157 blepharoptosis AE A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to, at which point AE symptoms begin to arise. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. AG, YH OBI AE associated dose range A healing process that leads to an outcome with improved relative health from an adverse event AG, YH AE recovery adverse event recovery an AE recovery rate that represents a rate of adverse event recovery AG, YH AE recovery rate An AE recovery that is sepcifically for recovery from a chemotherapy drug adverse event. AG, YH chemotherapy drug AE recovery AG, YH complete AE recovery an information content entity that represents an extent of recovery from an adverse event AG, YH extent of AE recovery an extent of AE recovery that has an outcome of incomplete recovery AG, YH incomplete AE recovery an epileptic seizure AE that is characterized by tonic-clonic seizures, involving two phases -- the tonic phase in which the body becomes rigid, and clonic phase in which there is uncontrolled jerking. JX, LW, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32957 癫痫大发作 10018658 grand mal AE Erythema simplex AE is an erythema AE that accompany with blushing or redness of the skin caused by a toxic reaction or a neurovascular phenomenon. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/erythema+simplex 单纯性红斑 erythema simplex AE Pelvic pain AE is a pain AE that occurs in the lower abdomen area. The pain might be steady, or it might come and go. If the pain is severe, it might get in the way of people's daily activities. JX, LW, YH, MW WEB: http://www.nlm.nih.gov/medlineplus/pelvicpain.html 骨盆痛 10034263 pelvic pain AE CTCAE:E13167 NCIt:C40122 Extrasystoles AE is an arrhythmia AE that shows a premature contraction of the heart that is independent of the normal rhythm of the heart and arises in response to an impulse in some part of the heart other than the normal impulse from the sinoatrial node. The extrasystole is followed by a pause, as the heart electrical system "resets" itself and the contraction following the pause is usually more forceful than normal. JX, LW, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32159 早搏（额外收缩） 10015856 extrasystoles AE An increased upper airway secretion AE is a respiratory system AE characterized by an increased secretion at the upper airway location. RR, YH 10062717 increased upper airway secretion AE Feeling of body temperature change AE is a feeling abnormal AE that a patient feels a change in body temperature. RR, YH 10061458 feeling of body temperature change AE Heartburn AE is a gastric disorder AE that also known as pyrosis, cardialgia, or acid indigestion. It's a burning sensation in the chest, just behind the breastbone or in the epigastrium, the upper central abdomen. The pain often rises in the chest and may radiate to the neck, throat, or angle of the jaw. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Heartburn 胃灼热（烧心） 10019326 heartburn AE Tonsillitis AE is an inflammation AE that is inflammation of the tonsils most commonly caused by viral or bacterial infection. Symptoms may include sore throat and fever. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Tonsillitis 扁桃体炎 10044008 tonsillitis AE Non-insulin-dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 2, it's characterized by hyperglycemia (high blood sugar) in the context of insulin resistance and relative lack of insulin. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 非胰岛素依赖型糖尿病 10029505 non-insulin-dependent diabetes mellitus AE Insulin dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 1. It results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1 胰岛素依赖型糖尿病 10022497 insulin dependent diabetes mellitus AE a hyporeflexia AE where the patient shows no sign of reflexes. JX, LW, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423 反射消失 10003084 areflexia AE Mastauxea AE is a reproductive system AE that shows enlargement of the breast. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/mastauxe 乳房增大 mastauxe AE Uveitis AE is an inflammation AE that is inflammation of the uvea, which lines the inside of the eye behind the cornea. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Uveitis 色素层炎 10046851 uveitis AE CTCAE: E10442 NCIt: C26909 Sexual dysfunctions AE is a reproductive system AE that is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm. JX, LW, YH sexual malfunction AE WEB: http://en.wikipedia.org/wiki/Sexual_dysfunction 性功能障碍 10040477 sexual dysfunctions AE Hypomnesia AE is a behavior and neurological AE that is an archaic term applied to poor memory, the impaired ability to recall information previously memorized. JX, LW, YH WEB: http://psychology.wikia.com/wiki/Hypomnesia 记忆减退 10021035 hypomnesia AE Phobia AE is a behavior and neurological AE that is a type of anxiety disorder, usually defined as a persistent fear of an object or situation in which the sufferer commits to great lengths in avoiding, typically disproportional to the actual danger posed, often being recognized as irrational. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Phobia 恐惧症 10034912 phobia AE Lymphadenectasis AE is an edema AE that shows enlargement of the lymph node. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/lymphadenectasis 淋巴结肿大 10025282 lymphadenectasis AE Asterixis AE is a tremor AE that also called the flapping tremor, or liver flap, which is a tremor of the hand when the wrist is extended, sometimes said to resemble a bird flapping its wings. This motor disorder is characterized by an inability to actively maintain a position, which is demonstrated by jerking movements of the outstretched hands when bent upward at the wrist. The tremor is caused by abnormal function of the diencephalic motor centers in the brain, which regulate the muscles involved in maintaining position. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Asterixis 扑翼样震颤 10003547 asterixis AE Parageusia AE is a gustatory system AE which is the medical term for a bad taste in the mouth. One common form of parageusia is a metallic taste of food. This can be a side effect of several medications, such as acetazolamide, eszopiclone, zopiclone, metronidazole, or etoposide. Metallic taste is also a type of dysgeusia which is frequently associated with infections in the mouth or upper airways. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Parageusia 味觉颠倒 10033793 parageusia AE Brain damage AE is a brain AE that also called brain injury is the destruction or degeneration of brain cells. In general, brain damage refers to significant, undiscriminating trauma-induced damage. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Brain_damage 脑损伤 10056389 brain damage AE Frequent bowel movements AE is a abnormal stool AE that people are having more bowel movements than is normal for them. Often, frequent bowel movements are accompanied by diarrhea, the passage of loosely formed stool. JX, LW, YH WEB: http://www.healthgrades.com/symptoms/frequent-bowel-movements 大便频繁 10017367 frequent bowel movements AE Hyperprolactinemia AE is an endocrine investigation result abnormal AE that is the presence of abnormally high levels of prolactin in the blood. Normal levels are less than 500 mIU/L [20 ng/mL or µg/L] for women, and less than 450 mIU/L for men. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hyperprolactinaemia 高泌乳素血症 10020739 hyperprolactinemia AE Galactorrhea AE is a reproductive system AE that is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Galactorrhea 乳溢 10017592 galactorrhea AE Sitophobia AE is a behavior and neurological AE that shows a morbid or insane dread of eating. JX, LW, YH WEB: http://en.wiktionary.org/wiki/sitophobia 畏食 sitophobia AE Ejection murmur AE is a cardiac disorder AE which is due to turbulent forward flow across the right and left ventricular outflow tract, aortic or pulmonary valve, or through the aorta or pulmonary artery. JX, LW, YH WEB: http://www.cardiologysite.com/auscultation/html/ejection_murmurs.html 收缩期喷射性杂音 ejection murmur AE Hypoactive sexual desire disorder AE is a libido disorder AE that is considered a sexual dysfunction and is characterized as a lack or absence of sexual fantasies and desire for sexual activity, as judged by a clinician. JX, LW, YH hyposexuality AE WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder 性欲减退 10020933 hypoactive sexual desire disorder AE Bigotry AE is a behavior and neurological AE that is a state of mind where a person strongly and unfairly dislikes other people, ideas, etc. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Bigotry 偏执 bigotry AE Somnambulisma AE is a behavior and neurological AE that also known as sleepwalking or noctambulism, which is a sleep disorder belonging to the parasomnia family. It arise from the slow wave sleep stage in a state of low consciousness and perform activities that are usually performed during a state of full consciousness. These activities can be as benign as sitting up in bed, walking to the bathroom, and cleaning, or as hazardous as cooking, driving, violent gestures, grabbing at hallucinated objects, or even homicide. JX, LW, YH noctambulism AE sleepwalking AE WEB: http://en.wikipedia.org/wiki/Sleepwalking 梦游症 10041347 somnambulism AE Hyperphagia AE is an eating disorder AE that also called polyphagia. It's a medical sign meaning excessive hunger and abnormally large intake of solids by mouth. It can be caused by disorders such as diabetes, Kleine–Levin syndrome (a malfunction in the hypothalamus), the genetic disorders Prader–Willi syndrome, and Bardet–Biedl syndrome. JX, LW, YH polyphagia AE 食欲过盛 WEB: http://en.wikipedia.org/wiki/Polyphagia 10020710 hyperphagia AE Corneal pigmentation is a eye AE shows that the melanin is in the superficial stroma and the basal layer of the corneal epithelium. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/corneal+pigmentation 角膜色素沉着 10011040 corneal pigmentation AE Chromatos AE is a skin AE shows that deposit of pigment in a normally unpigmented area or excessive pigmentation in a normally pigmented site. JX, LW, YH WEB: http://www.merriam-webster.com/medical/chromatosis 色素沉着 chromatosis AE Subclavian steal syndrome AE is an ischaemia AE that is a constellation of signs and symptoms that arise from retrograde (reversed) flow of blood in the vertebral artery or the internal thoracic artery, due to a proximal stenosis (narrowing) and/or occlusion of the subclavian artery. The arm may be supplied by blood flowing in a retrograde direction down the vertebral artery at the expense of the vertebrobasilar circulation. This is called the subclavian steal. JX, LW, YH subclavian steal phenomenon AE subclavian steal steno-occlusive disease AE 锁骨下动脉盗血综合征 10042335 subclavian steal syndrome AE Allergic rhinitis AE is a rhinitis AE that is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system. JX, LW, YH, MW WEB: http://en.wikipedia.org/wiki/Allergic_rhinitis 过敏性鼻炎 10001723 allergic rhinitis AE CTCAE:E13303 NCIt:C79532 Ventricular ectopic beats AE is a cardiac ventricular disorder AE that is a disturbance of the cardiac rhythm frequently related to the electrical conduction system of the heart, in which beats arise from fiber or group of fibers outside the region in the heart muscle ordinarily responsible for impulse formation. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Ectopic_beat 心室异位搏动 10058291 ventricular ectopic beats AE Sjogren syndrome AE is a eye AE that is a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands, that produce saliva and tears, respectively. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sj%C3%B6gren's_syndrome 干燥综合症 10040767 sjogren syndrome AE Nocturia AE is a urine abnormality AE that is defined by the International Continence Society as “the complaint that the individual has to wake at night one or more times for voiding”. JX, LW, YH nycturia AE WEB: http://en.wikipedia.org/wiki/Nocturia 夜尿症 10029446 nocturia AE Night sweat is a sweating AE that is the occurrence of excessive sweating (hyperhidrosis and focal hyperhidrosis) during sleep. The sufferer may or may not also suffer from excessive perspiration while awake. JX, LW, YH sleep hyperhidrosis AE WEB: http://en.wikipedia.org/wiki/Night_sweats 夜汗 10029409 night sweat AE Increased appetite AE is a gustatory system AE that is when people want to eat much more often or in larger quantities than their body requires. JX, LW, YH WEB: http://www.healthline.com/symptom/increased-appetite 食欲增加 10021654 increased appetite AE Vascular dilatation headache AE is a headache AE that shows headache which caused by vascular dilatation. JX, LW, YH WEB: http://www.headaches.org/education/Headache_Topic_Sheets/Vascular_Headaches 血管扩张性头痛 vascular dilatation headache AE Bundle-branch block AE is a conduction system disorder AE that refers to a defect of the heart's electrical conduction system. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Bundle_branch_block 束支传导阻滞 10006578 bundle-branch block AE Unstable diabetes AE is a diabetes mellitus AE that is a type of diabetes when a person's blood glucose level often swings quickly from high to low and from low to high. JX, LW, YH brittle diabetes AE labile diabetes AE WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=7271 不稳定型糖尿病 10006372 unstable diabetes AE Tendon rupture AE is a tendon disorder AE shows a tearing of the tendon that occurs when the forces placed upon the tendon exceed its tensile strength. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/Tendon+rupture 肌腱断裂 10043248 tendon rupture AE Tendovaginitis AE is an inflammation AE that is an acute or chronic inflammation of the tendon sheath, occurring in the region of the hand, the wrist joint, the forearm (radial and ulnar tenobursitis), the foot, the ankle joint, and the Achilles tendon (achillobursitis). JX, LW, YH tenovaginitis AE WEB: http://encyclopedia2.thefreedictionary.com/Tendovaginitis 腱鞘炎 10067216 tendovaginitis AE Loose stools AE is a abnormal stool AE that is usually a form of diarrhea and many conditions causing loose stool will be listed under diarrhea. It may also be related to watery stool (also within the spectrum of diarrhea). JX, LW, YH WEB: http://www.rightdiagnosis.com/sym/loose_stool.htm 稀便 10024840 loose stools AE Cystitis AE is an inflammation AE that is the medical term for inflammation of the bladder. Most of the time, the inflammation is caused by a bacterial infection, and it's called a urinary tract infection. JX, LW, YH WEB: http://www.mayoclinic.org/diseases-conditions/cystitis/basics/definition/con-20024076 膀胱炎 10011781 cystitis AE Eructation AE is a digestive system AE that is the release of gas from the digestive tract (mainly esophagus and stomach) through the mouth. It is usually accompanied with a typical sound and, at times, an odor. JX, LW, YH belching AE burping AE ructus AE WEB: http://en.wikipedia.org/wiki/Burping 嗳气 10015137 eructation AE Glossolalia AE is a speech disorder AE that is the fluid vocalizing of speech-like syllables that lack any readily comprehended meaning. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Glossolalia 语言不清 glossolalia AE Leg pain AE is a pain AE that is a common problem in leg, it can be due to a cramp, injury, or other cause. JX, LW, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003182.htm 腿痛 10024130 leg pain AE Stomachache AE is a pain AE that the pain in or near your stomach. It is a common symptom associated with transient disorders or serious disease. JX, LW, YH abdominal pain AE stomach pain AE stomachache AE WEB: http://en.wikipedia.org/wiki/Abdominal_pain http://www.nhs.uk/conditions/stomach-ache-abdominal-pain/Pages/Introduction.aspx 胃痛 10042126 stomach ache AE CTCAE: E10460 NCIt: C26682 Conduction block AE is a conduction system disorder AE that shows failure of impulse transmission at some point along a nerve fiber, although conduction along the segments proximal and distal to it are unaffected. JX, LW, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=10757 传导阻滞 conduction block AE Photodermatitis AE is a dermatitis AE that referred to as sun poisoning or photoallergy, is a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Photodermatitis 光敏性皮炎 photodermatitis AE Pygalgia AE is a pain AE that is a rarely used term meaning pain in the buttocks. JX, LW, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=74312 臀痛 pygalgia AE Throat irritation AE is a discomfort AE that refers to a dry cough, a scratchy feeling at the back of the throat, or a sensation of a lumpy feeling or something stuck at the back of the throat. JX, LW, YH throat discomfort AE WEB: http://en.wikipedia.org/wiki/Throat_irritation 咽喉不适 10043521 throat irritation AE Interstitial nephritis AE is an inflammation AE that is a form of nephritis affecting the interstitium of the kidneys surrounding the tubules. This disease can be either acute, meaning it occurs suddenly, or chronic, meaning it is ongoing and eventually ends in kidney failure. JX, LW, YH tubulointerstitial nephritis AE WEB: http://en.wikipedia.org/wiki/Interstitial_nephritis 间质肾炎 10048302 interstitial nephritis AE Hoarseness AE is a hoarseness AE that refers to a difficulty making sounds when trying to speak. Vocal sounds may be weak, breathy, scratchy, or husky, and the pitch or quality of the voice may change. JX, LW, YH, MW WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003054.htm 声音嘶哑 10020201 hoarseness AE CTCAE:E13384 NCIt:C47813 Photosensitization AE is a hypersensitivity AE that refers to development of abnormally heightened reactivity of the skin or eyes to sunlight. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/photosensitization 光敏 photosensitization AE Fanconi syndrome AE is a kidney AE that is a disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine, instead of being reabsorbed. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Fanconi_syndrome 范可尼综合征 10016219 fanconi syndrome AE Keratoconjunctivitis AE is an inflammation AE that is inflammation of the cornea and conjunctiva. When only the cornea is inflamed, it is called keratitis; when only the conjunctiva is inflamed, it is called conjunctivitis. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Keratoconjunctivitis 角膜结膜炎 10023348 keratoconjunctivitis AE Hepatic insufficiency AE is a liver disorder AE that shows a failure or partial failure of normal liver function. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/hepatic+insufficiency 肝功能不全 10056542 hepatic insufficiency AE Hypoxemia AE is a blood gas investigation result abnormal AE that is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hypoxemia 低血氧症 10021142 hypoxemia AE Irritant contact dermatitis AE is a dermatitis AE that is a form of contact dermatitis that can be divided into forms caused by chemical irritants and those caused by physical irritants. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Irritant_contact_dermatitis 刺激性接触性皮炎 irritant contact dermatitis AE Pitting edema AE is an edema AE that shows observable swelling of body tissues due to fluid accumulation that may be demonstrated by applying pressure to the swollen area (such as by depressing the skin with a finger). JX, LW, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=88528 指压性水肿 10054547 pitting edema AE Acute bronchitis AE is a bronchitis AE that is an inflammation of the large bronchi (medium-size airways) in the lungs that is usually caused by viruses or bacteria and may last several days or weeks. Characteristic symptoms include cough, sputum (phlegm) production, and shortness of breath and wheezing related to the obstruction of the inflamed airways. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Acute_bronchitis 急性支气管炎 10000687 acute bronchitis AE Renal calculus AE is a kidney AE that is a solid concretion or crystal aggregation formed in the kidneys from minerals in the urine. Kidney stones typically leave the body by passage in the urine stream, and many stones are formed and passed without causing symptoms. If stones grow to sufficient size (usually at least 3 millimeters (0.12 in)) they can cause blockage of the ureter. This leads to pain, most commonly beginning in the flank or lower back and often radiating to the groin or genitals. JX, LW, YH CTCAE: E13018 NCIt: C26807 kidney stone AE nephrolithiasis AE renal calculi AE WEB: http://en.wikipedia.org/wiki/Kidney_stone 肾结石 10038385 10038386 renal calculus AE Clouding of consciousness AE is a sensory capability AE that is a term used in conventional medicine denoting an abnormality in the "regulation" of the "overall level" of consciousness that is mild and less severe than a delirium. The sufferer experiences a subjective sensation of mental clouding described as feeling "foggy". JX, LW, YH brain fog AE mental fog AE WEB: http://en.wikipedia.org/wiki/Clouding_of_consciousness 意识模糊 clouding of consciousness AE Reflex tachycardia AE is a tachycardia AE that shows increased heart rate in response to some stimulus conveyed through the cardiac nerves. JX, LW, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=89526 反射性心动过速 10063096 reflex tachycardia AE Joint sprain AE is a joint disorder AE that is damage to one or more ligaments in a joint, often caused by trauma or the joint being taken beyond its functional range of motion. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sprain 关节扭伤 10023229 joint sprain AE Epicondylitis AE is an inflammation AE that is a type of musculoskeletal disorder that refers to an inflammation of an epicondyle. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Epicondylitis 上髁炎 10014971 epicondylitis AE Melanoglosia AE is a tongue AE that shows tongue turn black. Any blackening of the tongue associated with certain disorders and diseases in animals and humans. JX, LW, YH WEB: http://encyclopedia2.thefreedictionary.com/melanoglosia 舌黑 10014971 melanoglosia AE Ventricular tachycardia AE is a tachycardia AE that is a type of tachycardia, or a rapid heart beat that arises from improper electrical activity of the heart presenting as a rapid heart rhythm, that starts in the bottom chambers of the heart, called the ventricles. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Ventricular_tachycardia 心室性心搏过速 10047302 ventricular tachycardia AE CTCAE: E10239 NCIt: C50802 Granulomatous hepatitis AE is a hepatitis AE that refers to an inflammatory liver disease associated with granuloma formation in the liver. JX, LW, YH WEB: http://radiopaedia.org/articles/granulomatous-hepatitis 肉芽肿性肝炎 granulomatous hepatitis AE Hypogeusia AE is a gustatory system AE that is a reduced ability to taste things (to taste sweet, sour, bitter, or salty substances). JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hypogeusia 味觉减弱 10020989 hypogeusia AE Dysphoria AE is a behavior and neurological AE that is a profound state of unease or dissatisfaction. In a psychiatric context, dysphoria may accompany depression, anxiety, or agitation. Common reactions to dysphoria include emotional distress or indifference. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Dysphoria 烦躁不安 10013954 dysphoria AE Oneirism AE is a behavior and neurological AE that is a state of abnormal consciousness in which dream-like experiences and hallucinations happen while awake. JX, LW, YH WEB: http://en.wiktionary.org/wiki/oneirism 梦幻症 10030332 oneirism AE Podalgia AE is a pain AE that shows pain in the foot. JX, LW, YH WEB: http://en.wiktionary.org/wiki/podalgia 足痛 podalgia AE Brachialgia AE is a pain AE that shows pain in the arm. JX, LW, YH WEB: http://en.wiktionary.org/wiki/brachialgia 臂痛 10068901 brachialgia AE Coxalgia AE is a pain AE that shows pain in the hip. JX, LW, YH WEB: http://en.wiktionary.org/wiki/coxalgia 髋痛 10011249 coxalgia AE Limb injury AE is an injury AE which involve damage to bones, joints, ligament, musles, the major blood vessels and nerves of the limb. JX, LW, YH 肢体伤 10061225 limb injury AE Polymyalgia rheumatica AE is a muscle pain AE that is a syndrome with pain or stiffness, usually in the neck, shoulders, and hips. The pain can be very sudden, or can occur gradually over a period. It may be caused by an inflammatory condition of blood vessels such as temporal arteritis. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Polymyalgia_rheumatica 风湿性多发性肌痛 10036099 polymyalgia rheumatica AE Fibromyalgia AE is a muscle pain AE that is characterised by chronic widespread pain and allodynia (a heightened and painful response to pressure). Fibromyalgia symptoms are not restricted to pain, leading to the use of the alternative term fibromyalgia syndrome for the condition. Other symptoms include debilitating fatigue, sleep disturbance, and joint stiffness. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Fibromyalgia 纤维肌痛 10048439 fibromyalgia AE Hepatic encephalopathy AE is an encephalopathy AE that is the occurrence of confusion, altered level of consciousness, and coma as a result of liver failure. In the advanced stages it is called hepatic coma or coma hepaticum. JX, LW, YH portosystemic encephalopathy AE WEB: http://en.wikipedia.org/wiki/Hepatic_encephalopathy 10019660 hepatic encephalopathy AE a behavior and neurological AE AE that is an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias. JX, LW, YH choreia AE WEB: http://en.wikipedia.org/wiki/Chorea 舞蹈症 10008748 chorea AE Nightmare AE is a sleep disorder AE that is an unpleasant dream that can cause a strong emotional response from the mind, typically fear or horror but also despair, anxiety and great sadness. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Nightmare 梦魇 10029412 nightmare AE a psychiatric disorder AE that is an anomaly of self-awareness. It consists of a feeling of watching oneself act, while having no control over a situation. Subjects feel they have changed, and the world has become vague, dreamlike, less real, or lacking in significance. It can be a disturbing experience, since many feel that, indeed, they are living in a "dream". JX, LW, YH depersonalisation AE WEB: http://en.wikipedia.org/wiki/Depersonalization 人格解体 10012359 depersonalization AE a psychiatric disorder AE that refers to a state of mind where one is not disturbed by the passions. JX, LW, YH apathia AE WEB: http://en.wikipedia.org/wiki/Apatheia 情感冷漠 apatheia AE Parosmia AE is a sensory capability AE that is an olfactory dysfunction which is characterized by the inability of the brain to properly identify an odor’s “natural” smell. JX, LW, YH cacosmia AE troposmia AE 味觉倒错 WEB: http://en.wikipedia.org/wiki/Parosmia 10034018 parosmia AE Xerophthalmia AE is an eye AE that is a medical condition in which the eye fails to produce tears. JX, LW, YH xerophthalmus AE WEB: http://en.wikipedia.org/wiki/Xerophthalmia 干眼病 10048221 xerophthalmia AE Chondropathy AE is a bone disorder AE that refers to a disease of the cartilage. It is frequently divided into 5 grades, with 0-2 defined as normal, and 3-4 defined as diseased. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Chondropathy 软骨病 10061762 chondropathy AE Teratogenesis AE is a female reproductive system AE that is a prenatal toxicity characterized by structural or functional defects in the developing embryo or fetus. It also includes intrauterine growth retardation, death of the embryo or fetus, and transplacental carcinogenesis. JX, LW, YH WEB: http://www.britannica.com/EBchecked/topic/587782/teratogenesis 畸胎 teratogenesis AE Premature atrial contraction AE is an arrhythmia AE that is a common cardiac dysrhythmia characterized by premature heartbeats originating in the atria. JX, LW, YH atrial premature beats AE atrial premature complexes AE WEB: http://en.wikipedia.org/wiki/Premature_atrial_contraction 早搏 10056964 premature atrial contraction AE An inflammation AE that courrs in one or both parotid glands, the major salivary glands located on either side of the face, in humans. The parotid gland is the salivary gland most commonly affected by inflammation. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Parotitis 腮腺炎 10034038 parotitis AE Glossitis AE is an inflammation AE that can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal surface of the tongue, leaving a smooth and erythematous surface. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Glossitis 舌炎 10018386 glossitis AE Genital edema AE is an edema AE that can be the result of interruption to the lymphatic drainage of this area caused by tumor, surgical removal of lymph nodes, radiotherapy or infection. Congenital disorders causing inadequate lymphatics can sometimes lead to the development of this condition. JX, LW, YH, MW WEB: http://www.lymphoedemanz.org.nz/About+Lymphoedema/Genital+Oedema.html 生殖器水肿 10018146 genital edema AE CTCAE:E13111 NCIt:C78324 Orgasm incapacity AE is a reproductive system AE that the disorder characterized by an inability to achieve orgasm. JX, LW, YH 缺乏性高潮 orgasm incapacity AE Sedation AE is a behavior and neurological AE that is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sedation 镇静 10039897 sedation AE Sinus bradycardia AE is a bradycardia AE that is a heart rhythm that originates from the sinus node and has a rate that is lower than normal. In humans, bradycardia is generally defined to be a rate of under 60 beats per minute. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sinus_bradycardia 窦性心动过缓 10040741 sinus bradycardia AE CTCAE: E10208 NCIt: C26923 Cardiac output decreased AE is a cardiac disorder AE that shows a state in which the blood pumped by an individual's heart is sufficiently reduced that it is inadequate to meet the needs of the body's tissues. Cardiac output is the volume of blood being pumped by the heart, in particular by a left or right ventricle in the time interval of one minute. JX, LW, YH WEB: http://www1.us.elsevierhealth.com/MERLIN/Gulanick/archive/Constructor/gulanick10.html http://en.wikipedia.org/wiki/Cardiac_output 心输出量减少 10007595 cardiac output decreased AE Steatorrhea AE is a digestive system AE that is the presence of excess fat in feces. Stools may also float due to excess lipid, have an oily appearance and can be especially foul-smelling. JX, LW, YH steatorrhoea AE WEB: http://en.wikipedia.org/wiki/Steatorrhea 脂溢 10041968 steatorrhea AE Malabsorption syndrome AE is a digestive system AE that refers to a number of disorders in which the intestine’s ability to absorb certain nutrients, such as vitamin B12 and iron, into the bloodstream is negatively affected. JX, LW, YH WEB: http://www.healthline.com/health/malabsorption#Overview1 吸收不良综合症 10025479 malabsorption syndrome AE Sialadenitis AE is an inflammation AE that is inflammation of a salivary gland. It may be subdivided temporally into acute, chronic and recurrent forms. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sialadenitis 唾液腺炎 10040627 sialadenitis AE a nervous system AE that shows a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain, the cause of this cell death is unknown. JX, LW, YH choreia AE hypokinetic rigid syndrome AE idiopathic/primary parkinsonism AE paralysis agitans AE WEB: http://en.wikipedia.org/wiki/Parkinson's_disease 帕金森综合症 10061536 parkinson's disease AE Urinary calculus AE a urinary system AE that is solid particles in the urinary system. They may cause pain, nausea, vomiting, hematuria, and, possibly, chills and fever due to secondary infection. JX, LW, YH urinary calculi AE WEB: http://www.merckmanuals.com/professional/genitourinary_disorders/urinary_calculi/urinary_calculi.html 尿结石 10046531 urinary calculus AE Sinoatrial block AE is a conduction system disorder AE that shows the electrical impulse is delayed or blocked on the way to the atria, thus delaying atrial depolarization. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sinoatrial_block 窦房阻滞 10040736 sinoatrial block AE Hyperthyroidism AE is an endocrine system AE that is a condition in which the thyroid gland produces and secretes excessive amounts of the free (not protein bound circulating in the blood) thyroid hormones -triiodothyronine (T3) and/or thyroxine (T4). JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hyperthyroidism 甲状腺机能亢进 10020850 hyperthyroidism AE CTCAE: E10322 NCIt: C3123 Akathisia AE is a behavior and neurological AE that is a movement disorder characterized by a feeling of inner restlessness and a compelling need to be in constant motion, as well as by actions such as rocking while standing or sitting, lifting the feet as if marching on the spot, and crossing and uncrossing the legs while sitting. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace. JX, LW, YH, MW acathisia AE WEB: http://en.wikipedia.org/wiki/Akathisia 静坐困难 10001540 akathisia AE CTCAE:E12581 NCIt:C78163 Retinopathy AE is an eye AE that is due to persistent or acute damage to the retina of the eye. Ongoing inflammation and vascular remodeling may occur over periods of time where the patient is not fully aware of the extent of the disease. Frequently, retinopathy is an ocular manifestation of systemic disease as seen in diabetes or hypertension. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Retinopathy 视网膜病变 10038923 retinopathy AE CTCAE: E10432 NCIt: C62601 Sinus arrest AE is an arrhythmia AE that is a medical condition wherein the sinoatrial node of the heart transiently ceases to generate the electrical impulses that normally stimulate the myocardial tissues to contract and thus the heart to beat. It is defined as lasting from 2.0 seconds to several minutes. JX, LW, YH sinoatrial arrest AE sinus pause AE WEB: http://en.wikipedia.org/wiki/Sinoatrial_arrest 窦性停搏 10040738 sinus arrest AE ST segment depression AE is an electrocardiogram result abnormal AE that refers to a finding on an electrocardiogram. It may be determined by measuring the vertical distance between the patient's trace and the isoelectric line at a location 2-3 millimeters from the QRS complex. It is significant if it is more than 1 mm in V5-V6, or 1.5 mm in AVF or III. JX, LW, YH WEB: http://en.wikipedia.org/wiki/ST_depression ST段下降 10041892 ST segment depression AE T-wave inversion AE is an electrocardiogram result abnormal AE that can be a sign of coronary ischemia, Wellens' syndrome, left ventricular hypertrophy, or CNS disorder. In electrocardiography, the T wave represents the repolarization (or recovery) of the ventricles. JX, LW, YH WEB: http://en.wikipedia.org/wiki/T_wave T波倒置 10042966 T-wave inversion AE Hyperthermia AE is an abnormal body temperature AE that is elevated body temperature due to failed thermoregulation that occurs when a body produces or absorbs more heat than it dissipates. Extreme temperature elevation then becomes a medical emergency requiring immediate treatment to prevent disability or death. JX, LW, YH, SJ WEB: http://en.wikipedia.org/wiki/Hyperthermia 体温过高 10020843 hyperthermia AE Priapism AE a male reproductive system AE that is a potentially painful medical condition in which the erect penis does not return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Priapism 阴茎持续勃起 10036661 priapism AE Gingival bleeding AE is a hemorrhage AE that is a term used by dentists and dental hygienists when referring to bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus, or interface between the gingiva and a tooth. Bleeding on probing, often abbreviated BOP, is a sign of inflammation and indicates some sort of destruction and erosion to the lining of the sulcus or the ulceration of sulcular epithelium. The blood comes from lamina propria after the ulceration of the lining. JX, LW, YH bleeding gums AE bleeding on probing AE WEB: http://en.wikipedia.org/wiki/Bleeding_on_probing 牙龈出血 10018276 gingival bleeding AE a hearing disorder AE that is a partial or total inability to hear. In children it may affect the development of language and can cause work related difficulties for adults. JX, LW, YH anacusis AE deafness AE hard of hearing AE hearing impaired AE hearing impairment AE WEB: http://en.wikipedia.org/wiki/Hearing_loss 听力下降 10019245 10019246 hearing loss AE CTCAE: E10276 NCIt: C50576 Muscle fatigue AE is a muscle adverse event that is the decline in ability of a muscle to generate force. It can be a result of vigorous exercise but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction. JX, LW, YH physical fatigue AE WEB: http://en.wikipedia.org/wiki/Muscle_fatigue 肌肉疲劳 10049565 muscle fatigue AE Regurgitation AE is a digestive system AE that is the expulsion of material from the pharynx, or esophagus, usually characterized by the presence of undigested food or blood. JX, LW, YH http://en.wikipedia.org/wiki/Regurgitation_%28digestion%29 反胃 10067171 regurgitation AE Skin irritation AE is a skin AE that is a mild inflammatory dermal tissue reaction, it can be caused by physical contact with an irritant or can be a local response to a systemic trigger. JX, LW, YH 皮肤刺激 10040880 skin irritation AE a herpes viral infection AE tha is caused by both Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). JX, LW, YH herpes catarrhalis AE WEB: http://en.wikipedia.org/wiki/Herpes_simplex 单纯疱疹 10019948 herpes simplex AE Measles AE is a viral infection AE is an infection of the respiratory system, immune system and skin caused by a virus, specifically a paramyxovirus of the genus Morbillivirus. JX, LW, YH English measles AE morbilli AE rubeola AE WEB: http://en.wikipedia.org/wiki/Measles 麻疹 10027011 measles AE Hypercholesteremia AE is a blood cholesterol abnormal AE that is the presence of high levels of cholesterol in the blood. JX, LW, YH cholesterol high AE dyslipidemia hypercholesterolemia AE WEB: http://en.wikipedia.org/wiki/Hypercholesterolemia 高胆固醇血症 10005425 10008661 10020604 hypercholesteremia AE Toxic epidermal necrolysis AE is a skin AE that is a rare, life-threatening skin condition which is usually caused by a reaction to drugs. JX, LW, YH, MW Lyell's syndrome AE WEB: http://en.wikipedia.org/wiki/Toxic_epidermal_necrolysis 中毒性表皮坏死溶解症 10044223 toxic epidermal necrolysis AE CTCAE:E13743 NCIt:C79777 Atrioventricular junctional rhythm AE is an arrhythmia AE that is an electrocardiographic finding in which the pacer of the heart is located in the AV junction, presenting with a narrow QRS complex and a rate of 40-60 beats per minute. JX, LW, YH 房室交界性心律 atrioventricular junctional rhythm AE Unconsciousness AE is a sensory capability AE that is a state which occurs when the ability to maintain a awareness of self and environment is lost, it involves a complete or near-complete lack of responsiveness to people and other environmental stimuli. JX, LW, YH loss of consciousness AE WEB: http://en.wikipedia.org/wiki/Unconsciousness 意识丧失 10045481 unconsciousness AE Pemphigus AE is a skin AE that is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Pemphigus 天疱疮 10034280 pemphigus AE Onychomycosis AE is a nail infection AE that is a fungal infection of the nail. It is the most common disease of the nails and constitutes about half of all nail abnormalities. JX, LW, YH dermatophytic onychomycosis AE tinea unguium AE WEB: http://en.wikipedia.org/wiki/Onychomycosis 甲癣 onychomycosis AE Miosis AE is an eye AE that is a term with various definitions, which generally include constriction of the pupil. JX, LW, YH myosis AE WEB: http://en.wikipedia.org/wiki/Miosis 瞳孔缩小 10027646 miosis AE an optic neuropathy AE that shows the loss of some or most of the nerve fibers in the optic nerve. The effects range from visual change to severe visual loss. JX, LW, YH WEB: http://www.kellogg.umich.edu/patientcare/conditions/optic.atrophy.html 视神经萎缩 10030910 optic atrophy AE Albuminuria AE is a urine abnormality AE that is a pathological condition wherein albumin is present in the urine. It is a type of proteinuria. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Albuminuria 蛋白尿 10001580 albuminuria AE Enuresis AE is a urine abnormality AE that refers to a repeated inability to control urination. Use of the term is usually limited to describing individuals old enough to be expected to exercise such control. This term appears to be a synonym to the 'urinary incontinence AE'. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Enuresis 遗尿 10014928 enuresis AE Gum hypertrophy AE is a digestive system AE that is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications. JX, LW, YH gingival enlargement AE gingival hyperplasia AE gingival hypertrophy AE gingival over-growth AE hypertrophic gingivitis AE WEB: http://en.wikipedia.org/wiki/Gingival_enlargement 牙龈增生 10018781 gum hypertrophy AE Contact dermatitis AE is a dermatitis AE that is a type of skin inflammation.It results from exposure to allergens (allergic contact dermatitis) or irritants (irritant contact dermatitis). Phototoxic dermatitis occurs when the allergen or irritant is activated by sunlight. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Contact_dermatitis 接触性皮炎 10010790 contact dermatitis AE Necrotizing vasculitis AE is a vasculitis AE that is a rare condition which involves inflammation of the blood vessel walls. JX, LW, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000432.htm 坏死性血管炎 10028892 necrotizing vasculitis AE Carpal tunnel syndrome AE is a peripheral neuropathy AE that is a median entrapment neuropathy that causes paresthesia, pain, numbness, and other symptoms in the distribution of the median nerve due to its compression at the wrist in the carpal tunnel. JX, LW, YH median nerve neuropathy AE WEB: http://emedicine.medscape.com/article/1141168-clinical#showall WEB: http://en.wikipedia.org/wiki/Carpal_tunnel_syndrome 腕管综合征 10007697 carpal tunnel syndrome AE Erythromelalgia AE is a peripheral arterial disease AE that is a rare neurovascular peripheral pain disorder in which blood vessels, usually in the lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and inflamed. JX, LW, YH Mitchell's disease AE acromelalgia AE erythermalgia AE red neuralgia AE WEB: http://en.wikipedia.org/wiki/Erythromelalgia 红斑性肢痛症 10015284 erythromelalgia AE a syndrome AE which results in the Raynaud's syndrome, a rare disease causes some areas of your body — such as your fingers and toes — to feel numb and cold in response to cold temperatures or stress. In Raynaud's disease, smaller arteries that supply blood to your skin narrow, limiting blood circulation to affected areas (vasospasm). JX, LW, YH Raynaud's disease AE Raynaud's phenomenon AE WEB: http://www.mayoclinic.org/diseases-conditions/raynauds-disease/basics/definition/con-20022916 雷诺综合症 10037914 Raynaud's syndrome AE Extrapyramidal syndrome AE is a nervous system AE that is drug induced movement disorders which include acute and tardive symptoms. JX, LW, YH extrapyramidal side effects AE vertebral body outside the beam syndrome AE WEB: http://en.wikipedia.org/wiki/Extrapyramidal_symptoms 椎体外系综合征 10015836 extrapyramidal syndrome AE an electrolyte lab test abnormal AE that is when the kidneys hold on to more sodium and do not excrete it with the kidneys. This tends to expand the blood volume, which can elevate the blood pressure. JX, LW, YH WEB: https://answers.yahoo.com/question/index?qid=20100823074826AAcg7WV 钠潴留 10041277 sodium retention AE complex regional pain syndrome AE is a pain AE that results in an uncommon form of chronic pain that usually affects an extremity. SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/complex-regional-pain-syndrome/basics/definition/con-20022844 10064332 Complex regional pain syndrome typically develops after an injury, surgery, stroke or heart attack, but the pain is out of proportion to the severity of the initial injury. complex regional pain syndrome AE Sciatica AE is a pain AE that is a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve or by compression or irritation of the left or right or both sciatic nerves. JX, LW, YH lumbar radiculopathy AE sciatic neuralgia AE sciatic neuritis AE WEB: http://en.wikipedia.org/wiki/Sciatica 坐骨神经痛 10039674 sciatica AE Joint stiffness AE is a joint disorder AE that may be either the symptom of pain on moving a joint, the symptom of loss of range of motion or the physical sign of reduced range of motion. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Joint_stiffness 关节僵硬 10023230 joint stiffness AE Breast engorgement AE is a reproductive system AE that occurs in the mammary glands due to expansion and pressure exerted by the synthesis and storage of breast milk. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Breast_engorgement 乳房充盈 10006240 breast engorgement AE Nervous tension AE is a behavior and neurological AE that might be said to be a physical expression of how people deal with negatively experienced emotion. JX, LW, YH WEB: http://helpmetosleep.org/featured-articles/how-to-relieve-nervous-tension/ 神经紧张 10029214 nervous tension AE Nervousness AE is a behavior and neurological AE that shows an uneasy psychological state which including anxiety, neurosis, neuroticism, and worry, etc. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Nervousness 神经过敏 10029216 nervousness AE Osteoarthritis AE is an arthritis AE that is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Osteoarthritis is not an inflammatory disease even-though the name suggest one. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. JX, LW, YH degenerative arthritis AE degenerative joint disease AE osteoarthrosis AE WEB: http://en.wikipedia.org/wiki/Osteoarthritis 骨关节炎 10031161 osteoarthritis AE Methemoglobinemia AE is a red blood cell profile abnormal AE that is a disorder characterized by the presence of a higher than normal level of methemoglobin (metHb, i.e., ferric [Fe3+] rather than ferrous [Fe2+] haemoglobin) in the blood. It's a form of hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to bind oxygen. JX, LW, YH methaemoglobinaemia AE WEB: http://en.wikipedia.org/wiki/Methemoglobinemia 高铁血红蛋白症 10027506 methemoglobinemia AE Hemiageusia AE is a ageusia AE that shows loss of taste from one side of the tongue. JX, LW, YH hemiageustia AE hemigeusia AE WEB: http://www.medilexicon.com/medicaldictionary.php?t=39885 偏侧味觉缺失 hemiageusia AE Skin swelling AE is an edema AE that has an outcome of the occurrence of swelling which is located on the skin. JX, LW, YH WEB: http://www.rightdiagnosis.com/sym/skin_swelling.htm 胕肿 10053262 skin swelling AE Fibrosing alveolitis AE is a lung inflammation AE that is a disease of unknown cause mainly involving the gas-exchanging portions of the lungs. It may occur in isolation and be called cryptogenic or idiopathic, in which case the clinical manifestations are mainly respiratory, or it may be associated with other disorders, such as rheumatoid arthritis. JX, LW, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1818528/ 纤维化肺泡炎 10016640 fibrosing alveolitis AE an electrolyte chloride abnormal AE where the patient's body has abnormally low levels of chloride. This condition usually results from an extremely high loss of chloride, rather than a low intake of it. JX, LW, YH WEB: http://www.wisegeek.com/what-is-hypochloremic-alkalosis.htm 低氯性碱中毒 10020958 hypochloremic alkalosis AE Erythema annulare centrifugum AE is an erythema AE that is a descriptive term for a skin lesion. The lesions form consists of redness (erythema) in a ring form (anulare) that spreads from the center (centrifugum). JX, LW, YH MedDRA: 10015154 deep gyrate erythema AE erythema perstans AE palpable migrating erythema AE superficial gyrate erythema AE WEB: http://en.wikipedia.org/wiki/Erythema_annulare_centrifugum 离心性环形红斑 erythema annulare centrifugum AE Irritation is a behavior and neurological AE that is a state of inflammation or painful reaction to allergy or cell-lining damage. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Irritation 刺激 10029216 irritation AE a psychiatric disorder AE that is a fundamental personality trait in the study of psychology characterized by anxiety, fear, moodiness, worry, envy, frustration, jealousy, and loneliness. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Neuroticism 神经质 neuroticism AE Hyperirritability AE is a behavior and neurological AE that shows abnormally great or uninhibited response to stimuli. This term appears to be a synonym to the 'irritability AE'. JX, LW, YH WEB: http://www.merriam-webster.com/medical/hyperirritability; http://en.wikipedia.org/wiki/Irritability 过激 hyperirritability AE Rhinostenosis AE is a respiratory system AE that shows narrowing or obliteration of the nasal airway by scar formation JX, LW, YH WEB: http://www.drugs.com/dict/rhinostenosis.html 鼻道狭窄 rhinostenosis AE Sino-auricular heart-block AE is a conduction system disorder AE that refers to a rare heart condition caused by abnormalities in the heart's electrical system rather than arterial disease. JX, LW, YH WEB: http://www.rightdiagnosis.com/s/sino_auricular_heart_block/intro.htm 窦房传导阻滞 sino-auricular heart-block AE Anisosphygmia AE is a cardiovascular disorder AE that shows difference in volume, force, or time of the pulse in the corresponding arteries on two sides of the body, the two radials, or femorals. JX, LW, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=4352 脉搏不规则 anisosphygmia AE Rubefaction AE is a skin AE that refers to erythema of the skin caused by local application of a counterirritant. JX, LW, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=79112 发红 rubefaction AE Myodystony AE is an abnormal muscle tone AE that refers to a condition of slow relaxation, interrupted by a succession of slight contractions, following electrical stimulation of a muscle. JX, LW, YH WEB: http://www.drugs.com/dict/myodystony.html 肌张力不全 myodystony AE Allotriosmia is a behavior and neurological AE that shows incorrect recognition of odors. JX, LW, YH heterosmia AE WEB: http://www.medilexicon.com/medicaldictionary.php?t=2401 嗅觉异常 10029216 allotriosmia AE Pharyngotonsillitis is an inflammation AE that is a medical condition characterized by an inflammation of both the tonsils and the pharynx (located at the back of the throat). It occurs due to viral or bacterial infections. JX, LW, YH WEB: http://www.persify.com/en/perspectives/medical-conditions-diseases/pharyngotonsillitis-_-951000101807 咽扁桃体炎 10049140 pharyngotonsillitis AE Hypersensitivity pneumonitis AE is a pneumonia AE that is an inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. Sufferers are commonly exposed to the dust by their occupation or hobbies. JX, LW, YH extrinsic allergic alveolitis AE WEB: http://en.wikipedia.org/wiki/Hypersensitivity_pneumonitis 过敏性肺炎 10015887 hypersensitivity pneumonitis AE Stagger AE is a movement disorder AE that shows an unsteady movement of the body in walking or standing, as if one were about to fall. JX, LW, YH WEB: http://en.wiktionary.org/wiki/stagger 蹒跚 stagger AE Myocardial anoxia AE is a hypoxia AE that shows a reduced concentration of O2 in the myocardium. JX, LW, YH 心肌缺氧 myocardial anoxia AE Biliary colic AE is a pain AE that is the term used to describe a type of pain related to the gallbladder that occurs when a gallstone transiently obstructs the cystic duct and the gallbladder contracts. JX, LW, YH cholecystalgia AE WEB: http://en.wikipedia.org/wiki/Biliary_colic 胆绞痛 10004663 biliary colic AE Hyperemia AE is a cardiovascular disorder AE that is the increase of blood flow to different tissues in the body. It can have medical implications, but is also a regulatory response, allowing change in blood supply to different tissues through vasodilation. JX, LW, YH hyperaemia AE WEB: http://en.wikipedia.org/wiki/Hyperaemia 充血 hyperemia AE a sensory capability AE that has an outcome increased sensitivity to pain in a patient RR WEB: http://www.oxforddictionaries.com/us/definition/american_english/tenderness 10043224 tenderness AE a skin AE with the outcome of induration, which is an increase in the fibrous elements in tissue commonly associated with inflammation and marked by loss of elasticity and pliability or a hardened mass or formation RR WEB: http://www.merriam-webster.com/medical/induration 10060708 induration AE an eye AE which has an outcome of a foreign body sensation in the eye, or the sensation that something is in or scratching the eye RR WEB: http://www.richmondeye.com/eyehealth_foreignbody/ 10051116 foreign body sensation in eyes AE a cellulititis AE that occurs at an injection-site. RR WEB: http://www.nhs.uk/Conditions/Cellulitis/Pages/Symptoms.aspx 10050057 injection site cellulitis AE a sensory capability AE that has an outcome of peripheral coldness, or coldness of extremeties RR WEB: http://www.patient.co.uk/leaflets/peripheral_coldness.htm 10034568 peripheral coldness AE a hypoaesthesia AE that has an outcome of a decrease in facial sensitivity RR hypoaesthesia facial AE hypoesthesia facial AE WEB: http://www.webster-dictionary.org/definition/hypoesthesia 10065312 hypoesthesia facial AE a sleep disorder AE that shows poor quality sleep RR 10062519 poor quality sleep AE a rash AE characterized by the formation of vesicles RR rash vesicular AE WEB: http://www.merriam-webster.com/medical/vesicular 10037898 vesicular rash AE a discomfort AE that occurs at a limb RR 10061224 limb discomfort AE an eye disorder AE which has an outcome of discoloration of the sclera, or the whites of the eyes RR scleral discolouration AE 10039696 scleral discoloration AE an urticaria AE that occurs in an injection site RR WEB: http://www.uptodate.com/contents/hives-urticaria-beyond-the-basics 10022107 injection site urticaria AE a behavior and neurological AE that results in dysstasia, or difficulty standing RR WEB: http://www.medilexicon.com/medicaldictionary.php?t=27458 10050256 dysstasia AE a sensory capability AE that has an outcome of hyperaesthesia, meaning unusual or pathological sensitivity of the skin or of a particular sense RR hyperaesthesia AE WEB: http://www.merriam-webster.com/dictionary/hyperesthesia 神经过敏 10020568 hyperesthesia AE a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the spinal cord RR 10069585 nuclear magnetic resonance imaging spinal cord abnormal AE an eye disorder AE which has an outcome of ocular icterus, or jaundice of the eye RR WEB: http://www.merriam-webster.com/dictionary/icterus 10058117 ocular icterus AE An edema AE that occurs in the mouth RR oedema mouth AE 10030110 edema mouth AE a respiratory system AE which has an outcome of painful respiration, an unpleasant sensation ranging from mild discomfort to unbearable agony while breathing RR WEB: http://www.healthline.com/health/painful-respiration 10033517 painful respiration AE a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal ophthalmological examination RR 10056836 ophthalmological examination abnormal AE an optic neuropahty AE which shows an infarction of the optic disk which presents as painless vision loss RR optic ischemic neuropathy AE WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/ WEB: http://www.merckmanuals.com/professional/eye_disorders/optic_nerve_disorders/ischemic_optic_neuropathy.html 10030924 ischemic optic neuropathy AE a bacterial infection AE with an outcome of Lyme disease, a tick-bourne illness cause by the bacterium B. burgdorferi that causes dermatologic, rheumatologic, neurologic, and cardiac abnormalities RR WEB: http://wwwn.cdc.gov/nndss/script/casedef.aspx?CondYrID=752&DatePub=1/1/2011 10025169 lyme disease AE a pain AE that has an outcome of lymph node pain RR 10025182 lymph node pain AE CTCAE: E10052 NCIt: C78440 RR 10024860 a movement disorder AE that has an outcome of loss of control of patient's legs loss of control of legs AE a vascular disorder AE that has an outcome of levedo reticularis, a condition of the peripheral blood vessels characterized by reddish blue mottling of the skin especially of the extremeties usually upon exposure to cold RR WEB: http://www.merriam-webster.com/medical/livedo%20reticularis 10024648 livedo reticularis AE a muscle adverse event AE that has an outcome of muscle strain, which happens when a muscle is stretched too much and tears RR pulled muscle AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001109/ 10050031 muscle strain AE a muscle adverse event AE that has an outcome of muscle tightness, which is a tense feeling in muscles RR WEB: http://www.chirocommunity.com/muscletightness.htm 10049816 muscle tightness AE a muscle adverse event AE that has an outcome of muscle rigidity, a state of continuous firm, tense muscles with marked resistance to passive movement RR WEB: http://www.healthline.com/symptom/muscle-rigidity 肌肉僵硬 10028330 muscle rigidity AE Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barre syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes RR WEB: http://www.ninds.nih.gov/disorders/miller_fisher/miller_fisher.htm 10049567 Miller Fisher syndrome AE a hypersensitivity AE which has an outcome of type III immune complex mediated reaction, a type of hypersensitivity reaction in which circulating antigen-antibody immune complexes are deposited in post-capillary venules, with subsequent complement fixation RR WEB: http://emedicine.medscape.com/article/136217-overview 10053614 type III immune complex mediated reaction AE a tonsilitis AE with the outcome of tonsilar hypertrophy, or enlargement of the tonsils RR WEB: http://www.cchi.com.hk/symposia/s3_ear_1.htm 10044003 tonsilar hypertrophy AE a sensory capability AE that results in temperature intolerance RR 10057040 temperature intolerance AE a sensory capability AE that results in the patient being unresponsive to stimuli RR 10045555 unresponsive to stimuli AE a respiratory system AE that shows discolored sputum RR 10041806 sputum discolored AE a musculoskeletal system AE that has an outcome of spinal column stenosis, or narrowing of spaces in the spine that results in pressure on the spinal cord and/or nerve roots RR WEB: http://www.niams.nih.gov/Health_Info/Spinal_Stenosis/ 10041540 spinal column stenosis AE a skin AE with the outcome of skin tightness RR 10050637 skin tightness AE a pain AE with the outcome of ligament pain RR 10068790 ligament pain AE a thrombocytopenic purpura AE with no known cause (idiopathic). Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necesssary for normal blood clotting. Persons with this disorder have too few platelets in the blood. RR WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000535.htm 特发性血小板减少性紫癜 10021245 idiopathic thrombocytopenic purpura AE A palsy AE that shows cerebral palsy, a disorder of movement, muscle tone, or posture that is caused by an insult to the immature, developing brain, most often before birth RR WEB: http://www.mayoclinic.org/diseases-conditions/cerebral-palsy/basics/definition/con-20030502 10008129 cerebral palsy AE a neurological AE with the outcome of chronic inflammatory demyelinating polyradiculoneuropathy, a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms caused by damage to the myelin sheath of the peripheral nerves RR WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm 10057645 chronic inflammatory demyelinating polyradiculoneuropathy AE an allergy AE which displays an allergic skin response following contact of an allergen, with the skin typically marked by an itchy red rash often accompanied by swelling and watery blisters. RR, JX, YH dermatitis allergic AE WEB: http://www.merriam-webster.com/dictionary/allergic%20contact%20dermatitis 10012434 allergic dermatitis AE a behavior and neurological AE with an outcome of the patient refusing to eat RR 10012775 diet refusal AE an abnormal blood pressure AE that has an outcome of blood pressure fluctuations RR 10005746 blood pressure fluctuation AE a digestive system AE which has an outcome of aphagia, which is the loss of the ability to swallow RR WEB: http://www.merriam-webster.com/medical/aphagia 10049866 aphagia AE a speech disorder AE with an outcome of aphonia, or loss of voice and of all but whispered speech RR, MW WEB: http://www.merriam-webster.com/dictionary/aphonia 10002953 aphonia AE CTCAE:E12589 NCIt:C79539 a stomach pain AE that is observed in lower stomach RR WEB: http://www.mayoclinic.org/symptoms/abdominal-pain/basics/definition/sym-20050728 10000084 abdominal pain lower AE an eye AE with an outcome of an abnormal sensation in the eye RR 10000173 abnormal sensation in eye AE a behavior and neurological AE which has an outcome of impaired driving ability RR 10049564 impaired driving ability AE a respiratory system AE that has an outcome of increased bronchial secretion, or an increase in the substance produced in the bronchial tree, which includes mucus, protein salts, plasma fluid, and proteins RR WEB: http://medical-dictionary.thefreedictionary.com/bronchial+secretion 10062530 increased bronchial secretion AE an injection-site AE that displays injection site streaking, a red pattern on the skin localized to the injection site RR WEB: http://www.bannerhealth.com/incfiles/housecalls/peds/FeverInfectionsCrying/ImmunizationReactions.htm 10066778 injection site streaking AE an injection-site AE that displays injection site streaking, which are small, fluid-filled blisters localized to the injection site RR WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003939.htm 10022111 injection site vesicles AE a lab test abnormal AE that has an outcome of an increased international normalized ratio, indicating an individual is more prone to bleeding RR, MW, YH INR increased AE WEB: http://circ.ahajournals.org/content/126/5/e52.full 10022402 10022595 international normalized ratio increased AE CTCAE: E12175 NCIt: C78366 a sleep disorder AE with the outcome of irregular sleep phase, which is an abnormality in the timing of sleep RR WEB: http://www.mayoclinic.org/diseases-conditions/delayed-sleep-phase/basics/definition/con-20035242 10022995 irregular sleep phase AE an injection-site AE that displays injection site anesthesia, or numbness at the injection site RR 10022047 injection site anesthesia AE an infection AE that occurs at an injection-site RR WEB: http://www.merriam-webster.com/dictionary/infection 10022076 injection site infection AE a behavior and neurological AE which has an outcome of decreased grip strength, or a reduction in the force applied by the hand to pull on or suspend from objects RR WEB: http://www.krepublishers.com/02-Journals/JLS/JLS-01-0-000-09-Web/JLS-01-1-000-09-Abst-PDF/JLS-01-01-057-09-020-Koley-S/JLS-01-01-057-09-020-Koley-S-Tt.pdf 10062556 grip strength decreased AE an eye AE with the outcome of eyelid margin crusting RR 10052132 eyelid margin crusting AE an ear AE with the outcome of ear discomfort, an uncomfortable or painful feeling in the ear RR WEB: http://www.merriam-webster.com/dictionary/discomfort 10052137 ear discomfort AE an abnormal defecation AE that has an outcome of fecal incontinence, the accidental passing of solid or liquid stool or mucus from the rectum RR, MW, YH faecal incontinence AE WEB: http://digestive.niddk.nih.gov/ddiseases/pubs/fecalincontinence/#what 10016092 10016296 fecal incontinence AE CTCAE: E10693 NCIt: C78498 a behavior and neurological AE that has an outcome of fear, which is to be afraid and/or worried RR WEB: http://www.merriam-webster.com/dictionary/fear 10016275 fear AE a pain AE that has an outcome of pain in gums RR WEB: http://www.merriam-webster.com/dictionary/gingival 10018286 gingival pain AE CTCAE: E10763 NCIt: C78325 a tongue disorder with the outcome of glossitis, a condition in which the tongue is swollen and changes color, which may make the tongue appear smooth RR WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001053.htm 10018386 glossitis AE an injury AE which has an outcome of muscle injury RR 10028314 muscle injury AE a sensory capability AE that has an outcome of sensory disturbance RR 10040026 sensory disturbance AE an edema AE with an outcome of tracheal edema, which is the swelling of the airway between the throat and the lungs RR WEB: http://firstaidcalgary.ca/causes-of-tracheal-edema/ 10044296 tracheal edema AE Allergic eruption AE is a skin AE that is most drug-induced cutaneous reactions, especially found in younger adults. Sometimes also be diagnosed with eczema. This term appears to be a synonym to the 'eczema AE'. JX, LW, YH 过敏性皮疹 allergic eruption AE Erythrodermia AE is a skin AE that is an inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface. JX, LW, YH dermatitis exfoliativa AE exfoliative dermatitis AE red man syndrome AE WEB: http://en.wikipedia.org/wiki/Erythroderma 红皮病 10037165 erythrodermia AE Mycotic dermatitis is a dermatitis AE that is a inflammation of skin which induced by mycetes. JX, LW, YH 真菌性皮炎 mycotic dermatitis AE Peritendinitis symptom AE is an inflammation AE that has an outcome of inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced. JX, LW, YH 腱鞘炎样症状 peritendinitis symptom AE Orthostatic hypotension AE is a hypotension AE that is a form of hypotension in which a person's blood pressure falls when suddenly standing up or stretching. In medical terms, it is defined as a fall in systolic blood pressure of at least 20 mm Hg or diastolic blood pressure of at least 10 mm Hg when a person assumes a standing position. JX, LW, YH orthostasis AE postural hypotension AE WEB: http://en.wikipedia.org/wiki/Orthostatic_hypotension 直立性低血压 10031127 orthostatic hypotension AE JX, LW, YH chromatopsia AE WEB: http://ghr.nlm.nih.gov/condition/color-vision-deficiency 色视力缺乏 Color vision deficiency AE is an abnormal vision AE that is a group of conditions that affect the perception of color. They cause a range of changes in color vision, from mild difficulty with distinguishing shades to a total inability to detect color. These conditions are divided into three major categories: red-green color vision defects, blue-yellow color vision defects, and a complete absence of color vision. color vision deficiency AE Carcinogenesis AE is a tumor AE that is literally the 'creation' of cancer. It is a process by which normal cells are transformed into cancer cells. JX, LW, YH oncogenesis AE tumorigenesis AE WEB: http://en.wikipedia.org/wiki/Carcinogenesis 致癌 carcinogenesis AE a circulatory AE that is a serious allergic reaction associated with systemic vasodilation that causes low blood pressure which is by definition 30% lower than the person's baseline or below standard values. JX, LW, YH, RR WEB: http://en.wikipedia.org/wiki/Anaphylaxis WEB: http://smschile.cl/documentos/cursos2010/MedicalClinicsNorthAmerica/Acute%20Symptoms%20of%20Drug%20Hypersensitivity%20%28Urticaria,%20Angioedema,%20Anaphylaxis,%20Anaphylactic%20Shock%29.pdf WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=10092 过敏性休克 10002199 anaphylactic shock AE Pituitary adenomas AE is a tumor AE that is a tumor which occur in the pituitary gland. Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas, with carcinomas accounting for 0.1% to 0.2%, approximately 35% being invasive adenomas and most being benign adenomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Pituitary_adenoma pituitary adenomas AE Fatty infiltration AE is an embolism AE that shows the abnormal accumulation of fat droplets in the cytoplasm of cells. JX, LW, YH WEB: http://dictionary.reference.com/browse/fatty+infiltration 脂肪侵润 fatty infiltration AE Epigastric discomfort is a discomfort AE that shows discomfort in the upper central region of the abdomen. JX, LW, YH upper Abdominal discomfort AE WEB: http://www.rightdiagnosis.com/sym/epigastric_discomfort.htm 上腹部不适 10053155 epigastric discomfort AE Acute intravascular hemolysis AE is a cardiovascular AE that has an outcome of disruption of red blood cells occurs while they are within blood vessels. JX, LW, YH 急性血管内溶血 acute intravascular hemolysis AE Allergic hepatitis AE is a hepatitis AE that is a tissue-specific inflammatory diease caused by hepersensitivity to a particular drug, accomopanied by a systemic allergic reaction such as eosinophilia. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis 过敏性肝炎 10071198 allergic hepatitis AE Paranoid anxiety AE is a anxiety AE that is a term used in object relations theory, particularity in discussions about the Paranoid-schizoid and depressive positions. The term was frequently used by Melanie Klein, especially to refer to a pre-depressive and persecutory sense of anxiety characterised by the psychological splitting of objects. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Paranoid_anxiety 偏执性焦虑 paranoid anxietas AE Thrombotic thrombocytopenic purpura AE is a thrombocytopenic purpura AE that is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body. JX, LW, YH moschcowitz syndrome AE WEB: http://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura 血栓性血小板减少性紫癜 10043648 thrombotic thrombocytopenic purpura AE CTCAE: E10061 NCIt: C78797 Glaucoma AE is an eye AE that is a term describing a group of ocular (eye) disorders resulting in optic nerve damage or loss to the field of vision, in many patients caused by a clinically characterized pressure buildup in regards to the fluid of the eye (intraocular pressure-associated optic neuropathy). JX, LW, YH WEB: http://en.wikipedia.org/wiki/Glaucoma 青光眼 10018304 glaucoma AE CTCAE: E10392 NCIt: C26782 an allergy AE that shows a serious allergic reaction that is rapid in onset and may cause death. It typically causes a number of symptoms including an itchy rash, throat swelling, and low blood pressure. Common causes include insect bites and stings, foods, and medications. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Anaphylaxis 过敏症 10002218 anaphylaxis AE CTCAE: E11254 NCIt: C50460 an allergy AE which occur during certain times of the year, usually when outdoor molds release their spores, and trees, grasses, and weeds release tiny pollen particles into the air to fertilize other plants. JX, LW, YH WEB: http://kidshealth.org/parent/medical/allergies/seasonal_allergies.html 季节性变态反应 10048908 seasonal allergy AE a blood sodium abnormal AE with an abnormally decreased sodium concentration in the blood YH, MW hyponatraemia AE WEB: http://www.mayoclinic.org/diseases-conditions/hyponatremia/basics/definition/con-20031445 10021036 10021038 hyponatremia AE CTCAE: E12339 NCIt: C37976 Skin redness AE is an erythema AE that is abnormal redness of the skin, often signaling a pathological condition, such as inflammation, infection, or sunburn. JX, LW, YH WEB: http://www.healthline.com/health/skin-redness 皮肤发红 skin redness AE a chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood. DJ, SS, YH chest pain - cardiac AE tight chest AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723 10002383 10008481 angina AE CTCAE: E10110 HPO: HP_0001681 NCIt: C51221 SIDER: C0002962 an angina AE that is aggravating. JX, YH aggravating angina AE an aggravating angina AE that is caused by severe hypotension JX, YH 严重低血压导致心绞痛症状加重现象 severe hypotension caused angina symptom aggravating AE an eye AE that shows abnormal involuntary blinking of the eyelids JX, LW, YH corneal reflex abnormal AE URL: https://en.wikipedia.org/wiki/Corneal_reflex 睑闭反射反常 10058960 blink reflex abnormal AE Dazzling AE is a eye disorder AE that has an outcome of the consequence of illumination too intense for adaptation by the eye. In contrast to glare, dazzling is alleviated by appropriate tinted glasses. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/dazzling 目眩 dazzling AE Ventricular rhythm AE is an arrhythmia AE that shows the electrocardiographic finding of an ectopic ventricular rhythm with three or more consecutive ventricular premature beats with a rate less than 100 beats per minute. JX, LW, YH 室性心律 10047297 ventricular rhythm AE Extrapyramidal signs AE is a nervous system AE that shows defects in basal ganglia function. It characterized by changes in muscle tone, poverty of voluntary movements (akinesia), or abnormal involuntary movements (dyskinesia). JX, LW, YH 锥体外体征 extrapyramidal signs AE Hearing disorder AE is an ear disorder that shows impairment of the sense of hearing. JX, LW, YH 听觉障碍 10019243 hearing disorder AE Yellow urine AE is a urine abnormality AE that may be due to excretion of picric acid, dinitrophenol, phenacetin or chrysarobin or in alkaline pH, to increased secretion of anthocyanin, or associated with ingestion of beets or blackberries. Pure yellow urine is associated with increased acriflavine and has a green fluorescence; yellow-orange urine may be highly concentrated or contain increased bilirubin and biliverdin. JX, LW, YH 尿液呈黄色 yellow urine AE Epidermal necrosis AE is a necrosis AE that shows widespread keratinocyte cell death via apoptosis results in the tissue damage. JX, LW, YH 表皮坏死 10059284 epidermal necrosis AE Arthromeningitis AE is an inflammation AE that shows inflammation of a synovial membrane, usually painful, particularly on motion, and characterized by fluctuating swelling, due to effusion in a synovial sac. JX, LW, YH 滑膜炎 arthromeningitis AE Pulmonary tuberculosis AE is a lung disorder AE that is a contagious bacterial infection that involves the lungs. It may spread to other organs. JX, LW, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000077.htm 10037440 pulmonary tuberculosis AE Coronary heart disease AE is a cardiovascular disorder AE that is a disease in which a waxy substance called plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle. JX, LW, YH WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/cad/ 冠心病 10068617 coronary heart disease AE Increased defecation frequency AE is a abnormal stool AE that shows defecation number increased. JX, LW, YH 大便次数增加 increased defecation frequency AE Symptomatic hypotension AE is a hypotension AE that shows blood pressure that less than 90/60 mm Hg with dizziness, vertigo etc. JX, LW, YH 症状性低血压 symptomatic hypotension AE Non-specific gastrointestinal dysfunction AE is a gastrointestinal disorder AE that shows non-specific gastrointestinal dysfunction. JX, LW, YH 非特异性胃肠功能紊乱 non-specific gastrointestinal dysfunction AE Abnormal sclerotin AE is a bone disorder AE that shows abnormal sclerotin. JX, LW, YH 骨质异常 abnormal sclerotin AE Fast and weak heart beat AE is a cardiac disorder AE that shows fast and weak heart beat. JX, LW, YH 心跳快而弱 fast and weak heart beat AE Pain over the liver AE is a pain AE that shows pain over the liver. JX, LW, YH 肝区痛 pain over the liver AE Increased biliary calculus AE is a liver, biliary, and pancreatic AE that shows increased biliary calculus. JX, LW, YH 胆石增加 increased biliary calculus AE Muscle function disorder AE is a muscle AE that shows muscle function disorder. JX, LW, YH 肌肉功能失调 muscle function disorder AE Accidental injury AE is a fall AE that shows accidental falls. JX, LW, YH 意外跌倒 accidental fall AE Accidental injury AE is an injury AE that shows accidedntal injury. JX, LW, YH 意外损伤 10000380 accidental injury AE Abnormal ejaculation AE is a male reproductive system AE that shows abnormal ejaculation. JX, LW, YH 异常射精 10000128 abnormal ejaculation AE Distention of head AE is a cardiovascular AE that shows distention of head. JX, LW, YH 头胀 distention of head AE Water-sodium retention AE is an abnormal fluid regulation AE that shows water-sodium retention. JX, LW, YH WEB: http://www.livestrong.com/article/485782-sodium-retention-weight-gain/ 水钠潴留 water-sodium retention AE Dizziness when standing up AE is a dizziness AE that shows dizziness when standing up. JX, LW, YH 站起时头晕 dizziness when standing up AE Change of gustation AE is a gustatory system AE that shows the change of gustation. JX, LW, YH 味觉改变 change of gustation AE Vascular stimulation of pain AE is a pain AE that shows pain which due to vascular stimulation. JX, LW, YH 血管刺激性疼痛 vascular stimulation of pain AE Vascular pain AE is a pain AE that shows vascular pain. JX, LW, YH 血管疼痛 vascular pain AE Heaviness sense of arm AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the arm. JX, LW, YH 手臂沉重感 heaviness sense of arm AE Breast swelling AE is an edema AE that is common for almost all women in the second half of their menstrual cycle. It in the premenstrual portion of the cycle can be mild to severe. JX, LW, YH WEB: http://www.healthgrades.com/symptoms/breast-swelling 乳房肿胀 10006312 breast swelling AE Gastrointestinal cramp AE is a muscle spasm AE that shows abnormal contractions of the gastrointestinal muscles. JX, LW, YH 肠胃痉挛 10049136 gastrointestinal cramp AE Heart discomfort AE is a discomfort AE that shows an uncomfortable feeling in the heart. JX, LW, YH 心脏不适 heart discomfort AE Angiectopia of skin AE a vascular disorder AE that shows abnormal position or course of a vessel in the skin. JX, LW, YH 皮肤血管异位 angiectopia of skin AE Joint discomfort AE is a discomfort AE that shows an uncomfortable feeling in the joint. JX, LW, YH 关节不适 joint discomfort AE Eye discomfort AE is a discomfort AE that shows an uncomfortable feeling in the eye. JX, LW, YH 眼部不适 eye discomfort AE Instability of gait AE is a abnormal gait AE that shows instability of gait. JX, LW, YH 步态不稳 instability of gait AE Pemphigoid injury AE is an injury AE that shows a skin disorder where one has large blisters on the skin. JX, LW, YH 类天疱疮样损伤 pemphigoid injury AE Pulse frequency change AE is a cardiovascular AE that shows dpulse frequency change. JX, LW, YH pulse abnormal AE 脉搏频率变化 pulse frequency change AE Inhibition of myocardial contraction force AE is a cardiac disorder AE that shows inhibition of myocardial contraction force. JX, LW, YH 抑制心肌收缩力 inhibition of myocardial contraction force AE Decreased of atrial conduction velocity AE is a conduction system disorder AE that shows decreased of atrial conduction velocity. JX, LW, YH 心房传导速度减慢 decreased of atrial conduction velocity AE Spasm of lower limbs AE is a muscle spasm AE that shows tightening and spasms of the muscles in the legs. JX, LW, YH 下肢痉挛 spasm of lower limbs AE Electrocardiogram prolonged PR interval AE is an electrocardiogram result abnormal AE that shows a prolonged time between the onset of atrial depolarization (P wave) to the beginning of ventricular depolarization (QRS complex). JX, LW, YH 心电图出现PR间期延长 electrocardiogram prolonged PR interval AE Qrs wave broadening AE is a electrocardiogram qrs complex abnormal AE that shows broadening qrs complex in the electrocardiogram. JX, LW, YH QRS波增宽 qrs wave broadening AE Edema of lower limbs AE is an edema AE that shows enlargement of the leg, due to the accumulation of fluids. JX, LW, YH 下肢浮肿 edema of lower limbs AE Accelerated pulse AE is a cardiovascular AE that shows increased of the number of pulsations per minute palpable in an artery. JX, LW, YH 脉搏加快 accelerated pulse AE Bitter taste of mouth AE is a digestive system AE that is not from a bitter substance is a distorted sense of taste. A persistent bad taste in the mouth, whether bitter, metallic or foul, is called dysgeusia. JX, LW, YH WEB: http://www.healthgrades.com/symptoms/bitter-taste-in-mouth 口苦 bitter taste of mouth AE Skin irritant reaction AE is a skin AE that shows rash, inflammation, swelling, scaling, or abnormal tissue which growth in the affected area. JX, LW, YH 皮肤刺激反应 skin irritant reaction AE Vitreous suspended substance AE is an eye AE shows vitreous suspended substance in the eyes. JX, LW, YH 玻璃体悬浮物 vitreous suspended substance AE Dreaminess AE is a sleep disorder AE that shows dreaminess in the sleeping. JX, LW, YH 多梦 dreaminess AE Abdominal spasm AE is a muscle spasm AE that is typically a feeling of cramping in the abdomen caused by a rigid expansion of muscles. It can vary from mild discomfort to moderate or severe pain. JX, LW, YH WEB: http://www.wisegeekhealth.com/what-are-abdominal-spasms.htm 腹部痉挛 10051889 abdominal spasm AE Coronary contraction AE is a coronary artery disorder AE that shows coronary contraction. JX, LW, YH 冠状动脉收缩 coronary contraction AE Lower extremity edema caused by blood vessels AE is an edema AE that shows excess fluid accumalated in the leg dut to blood vessels. JX, LW, YH 因血管扩张引起的下肢水肿 lower extremity edema caused by blood vessels AE Asthenia of lower limbs AE is a asthenia AE that occurs in the lower limbs. It is a condition typified by a weakness of voluntary movement. JX, LW, YH 下肢无力 asthenia of lower limbs AE Small bronchial lumen occlusion AE is a lung disorder AE that shows small bronchial lumen occlusion. JX, LW, YH 小支气管腔闭塞 small bronchial lumen occlusion AE Prolonged orthostatic hypotension AE is a orthostatic hypotension AE that shows prolonged orthostatic hypotension. JX, LW, YH 延长体位性低血压时间 prolonged orthostatic hypotension AE an allergy AE that shows produce cross or incomplete cross allergic reaction to similar medicinal chemistry structure. JX, LW, YH 交叉过敏反应 cross allergic reaction AE Deep venous thrombophlebitis AE is a thrombophlebitis AE that is causes by a blood clot blocking in the deep vein. JX, LW, YH 深静脉血栓静脉炎 deep venous thrombophlebitis AE Change of hematology AE is a hematology investigation result abnormal AE that shows the change of hematology. JX, LW, YH 血液学改变 change of hematology AE Cardiac depression AE is a cardiac disorder AE that shows cardiac depression. JX, LW, YH 抑制心脏 cardiac depression AE Side limb numbness AE is a numbness AE that shows reduced or loss of sensation on the skin of an arm and leg on the same side of the body. JX, LW, YH 侧肢的麻木感 side limb numbness AE Numbness of tongue AE is a numbness AE that shows abnormal feeling or loss of sensation in the tongue. JX, LW, YH 舌部麻木 numbness of tongue AE Numbness of the limbs AE is a numbness AE that shows reduced or loss of sensation on the skin of the arm and leg. JX, LW, YH 肢体麻木 numbness of the limbs AE Lip numbness AE is a numbness AE that shows abnormal feeling in the lips, including numbness and tingling. JX, LW, YH 嘴唇发麻 lip numbness AE Reflex Increased pulse rate AE is a cardiovascular AE that shows increased pulse rate. JX, LW, YH 反射性脉率增加 reflex Increased pulse rate AE Irritation of the digestive tract AE is a digestive system AE that shows irritation of the digestive tract. JX, LW, YH 消化道刺激 irritation of the digestive tract AE Unconscious chorea AE is a chorea AE that is characterized by brief, non-repetitive irregular muscle contractions. JX, LW, YH 不自觉舞蹈症 unconscious chorea AE Phlebectasia of limbs AE is a vasodilatation AE that shows dilation of the veins in the extremity. JX, LW, YH 肢端静脉扩张 phlebectasia of limbs AE Heart beat skip AE is a irregular heartbeat AE which is sometimes called as either heart palpitation, or premature atrial or ventricular contraction are very common occurrences. They may or may not be accompanied by heart conditions or heart problems. JX, LW, YH WEB: http://ehealthwall.com/heart-skips-a-beat-causes-symptoms-treatment/ 漏跳 heart beat skip AE Fatal liver cell necrosis AE is a hepatic necrosis AE that has an outcome of fatal liver cell necrosis. JX, LW, YH 致命性肝细胞坏死 fatal liver cell necrosis AE Warm and hot feeling in the neck AE is a skini warm AE that shows warm and hot feeling in the neck. JX, LW, YH 颈感觉温热 warm and hot feeling in the neck AE Facial warm feeling AE is a skin warm AE that shows a warm feeling in the face. JX, LW, YH 面部感觉温热 facial warm feeling AE Increased peripheral vascular resistance AE is a vascular disorder AE that shows increased peripheral vascular resistance, the degree to which the blood vessels impede the flow of blood. High resistance causes an increase in blood pressure, which increases the workload of the heart. JX, LW, YH 外周血管阻力升高 increased peripheral vascular resistance AE Venous ischemia AE is an ischaemia AE that shows in insufficient blood supply in the vein. JX, LW, YH 静脉供血不足 venous ischemia AE Increased blood creatine AE is a metabolic and nutritional investigation result abnormal AE that shows an increased creatine level in blood. JX, LW, YH 血肌酸增加 increased blood creatine AE Increased nonprotein nitrogen AE is an investigation result abnormal AE that shows increased nonprotein nitrogen, the nitrogenous constituents of the blood exclusive of the protein bodies, consisting of the nitrogen of urea, uric acid, creatine, creatinine, amino acids, polypeptides, and an undetermined part known as rest nitrogen. JX, LW, YH 非蛋白氮增加 increased nonprotein nitrogen AE Soft feces AE is a abnormal stool AE that shows soft and shapeless of the feces. JX, LW, YH 软便 soft feces AE Increased hepatic function AE is a hepatic function abnormal AE that shows the values of liver function tests (LFTs) high than the normal. JX, LW, YH WEB: http://www.webmd.com/a-to-z-guides/liver-function-test-lft 肝功能升高 increased hepatic function AE Knee pain AE is a pain AE that shows discomfort in the structures of both knees. Keen pain may be due to injury, inflammation or infection. JX, LW, YH WEB: http://www.mayoclinic.org/diseases-conditions/knee-pain/basics/definition/CON-20029534 膝痛 10023477 knee pain AE Loss of libido AE is a libido disorder AE that shows loss of the desire for sexual interaction. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder 性欲丧失 10024870 loss of libido AE Over sedation AE is a behavior and neurological AE that shows the over reduction of irritability or agitation. JX, LW, YH 过度镇静 over sedation AE Finger tremor AE is a tremor AE that shows involuntary muscle contraction and relaxation in the finger. JX, LW, YH 手指强硬颤动 finger tremor AE Leg cramp AE is a muscle cramp AE that shows tightening, or spasms, of the muscles in the legs. JX, LW, YH 腿部痉挛 leg cramp AE a sleep disorder AE in which there is an inability to fall asleep or to stay asleep as long as desired. YH, MW WEB: https://en.wikipedia.org/wiki/Insomnia 10022437 Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease. insomnia AE CTCAE: E12925 HPO: HP_0002360 SIDER: C0917801 Terminal insomnia AE is a insomnia AE that is a medical condition affecting sleep patterns. Typically, people who suffer from terminal insomnia wake up after only four to five hours of sleep. For those afflicted, getting back to sleep can be difficult, resulting in fatigue, irritability, and lack of concentration. JX, LW, YH matutinal insomnia AE WEB: http://www.wisegeek.com/what-is-terminal-insomnia.htm 早醒 10068932 terminal insomnia AE Bone marrow granuloma AE is a bone marrow disorder AE that shows an organized collection of macrophages in the bone marrow. JX, LW, YH 骨髓肉芽肿 10066816 bone marrow granuloma AE Cholestatic liver injury AE is a liver damage AE that shows buildup of bile acids in hepatocytes, then causes hepatocellular injury. JX, LW ,YH 胆汁郁积性肝损伤 10067969 cholestatic liver injury AE Distant heart sounds AE is a cardiac disorder AE that shows distant heart sounds. JX, LW, YH 心音遥远 distant heart sounds AE Pink skin AE is a skin AE that shows pink skin. JX, LW, YH 皮肤粉红 pink skin AE Acute laryngeal edema AE is an edema AE that shows acute laryngeal edema, abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions. JX, LW, YH 急性喉头水肿 10066705 acute laryngeal edema AE Hypoplastic bone marrow AE is a bone marrow disorder AE that shows insufficient blood stem cells in the marrow. JX, LW, YH 骨髓发育不全 hypoplastic bone marrow AE Bleeding and coagulation disorders AE is a hematopoietic system AE that shows bleeding and coagulation disorders. JX, LW, YH 出凝血功能障碍 bleeding and coagulation disorders AE Polymorphic ventricular tachycardia AE is a ventricular tachycardia AE that is an abnormally fast heart rhythm starting in the ventricles, the lower chambers of the heart. JX, LW, YH WEB: http://www.healthguideinfo.com/arrhythmias-heart-palpitations/p110132/ 多行性室性心动过速 10036095 polymorphic ventricular tachycardia AE Monomorphic ventricular tachycardia AE is a ventricular tachycardia AE that is a type of tachycardia which has a uniform beat-to-beat QRS morphology. JX, LW, YH 单行性室性心动过速 10058185 monomorphic ventricular tachycardia AE Respiratory tract symptoms AE is a respiratory system AE that is a series of discomforts which occurs in respiratory tract. JX, LW, YH 呼吸道症状 respiratory tract symptoms AE Clammy skin AE is a skin AE that occurs when the skin turns cooler than normal and is moist, despite a cooler surface temperature. Clammy skin is often pale. JX, LW, YH WEB: http://www.healthgrades.com/symptoms/clammy-skin 皮肤湿冷 clammy skin AE Abnormal visual accommodation AE is an abnormal vision AE that shows abnormal visual accommodation. Accommodation is the process by which the vertebrate eye changes optical power to maintain a clear image or focus on an object as its distance varies. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Accommodation_%28eye%29 视调节异常 abnormal visual accommodation AE an allergy AE that shows swelling and irritation of the skin, caused by an allergy to a substance in the environment. JX, LW, YH 皮肤过敏 skin allergy AE Heaviness of the head AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the head. JX, LW, YH 头重感 10049121 heaviness of the head AE Rheumatoid factor positive AE is an immunology and allergy investigation result abnormal AE that shows positive of the rheumatoid factor. Rheumatoid factor is a blood test that measures the amount of the RF antibody in the blood. JX, LW, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003548.htm 类风湿因子阳性 10039080 rheumatoid factor positive AE Retinal detachment AE is an eye AE that is a separation of the retina from its attachments to the underlying tissue within the eye. JX, LW, YH WEB: http://www.medicinenet.com/retinal_detachment/article.htm 视网膜脱离 10038848 retinal detachment AE CTCAE: E10420 NCIT: C26874 NCIt: C26874 Arm pain AE is a pain AE that shows discomfort in the structures of the arm. It can be caused by a wide variety of problems, ranging from joint injuries to compressed nerves. JX, LW, YH WEB: http://www.mayoclinic.org/symptoms/arm-pain/basics/definition/SYM-20050870 手臂疼痛 arm pain AE Peripheric paresthesia AE is a paresthesia AE that shows paresthesia in the peripheric area. JX, LW, YH 外周感觉异常 peripheric paresthesia AE Edema of glottis AE is an edema AE that is a swelling caused by fluid accumulation in the soft tissues of the larynx. The condition, usually inflammatory, may result from an infection, injury, allergy, or inhalation of toxic substances. JX, LW, YH 声门肿胀 edema of glottis AE Prolonged qrs complex AE is a electrocardiogram qrs complex abnormal AE that shows qrs complex prolonged. The QRS complex is a name for the combination of three of the graphical deflections seen on a typical electrocardiogram. JX, LW, YH QRS时间延长 prolonged qrs complex AE Prolonged bleeding time AE is a hematology investigation result abnormal AE that shows prolonged time for small blood vessels in the skin close to stop from bleeding. JX, LW, YH 出血时间延长 prolonged bleeding time AE Acute generalized exanthematous pustulosis AE is a skin AE that is a not uncommon cutaneous reaction pattern that in 90% of cases is related to medication administration, characterized by a sudden eruption that appears on average five days after the medication is started. JX, LW, YH pustular drug eruption AE toxic pustuloderma AE WEB: http://en.wikipedia.org/wiki/Acute_generalized_exanthematous_pustulosis 急性全身性浓疱病 10062372 acute generalized exanthematous pustulosis AE Upper and lower limbs flare AE is an edema AE that shows edema in the upper and lower limbs, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues. JX, LW, YH 上下肢红肿 upper and lower limbs flare AE Abnormal blood sugar with empty stomach AE is a blood glucose level abnormal AE that shows abnormal blood glucose level with empty stomach. JX, LW, YH 空腹时血糖异常 abnormal blood sugar with empty stomach AE Increased blood sugar with empty stomach AE is blood glucose level decreased AE that shows an increased glucose level in blood with empty stomach. JX, LW, YH 空腹时血糖升高 increased blood sugar with empty stomach AE Hydrochloric acid in gastric juice secretion increased AE is a gastric disorder AE that shows increased gastric acid. JX, LW, YH 胃酸分泌增多 hydrochloric acid in gastric juice secretion increased AE Torsades de pointes AE is a ventricular tachycardia AE that is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Torsades_de_pointes 扭转性室速 10044067 torsades de pointes AE Proximal myasthenia AE is a myasthenia AE that shows proximal myasthenia. Myasthenia represents myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatigability. JX, LW, YH 近端肌无力 proximal myasthenia AE Dilated skin vessels AE is a vasodilatation AE that shows vasodilatation in the skin, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. JX, LW, YH 皮肤血管扩张 dilated skin vessels AE Numbness of oral mucosa AE is a numbness AE that shows an abnormal feeling or loss of sensation in the oral mucosa. JX, LW, YH 口腔黏膜发麻 numbness of oral mucosa AE Orthostatic dizziness AE is a dizziness AE that shows dizziness provocation by sudden postural change. JX, LW, YH 体位性头晕 10031125 orthostatic dizziness AE Acid reflux AE is a digestive system AE that shows the acid and pepsin secreted in the stomach back up in to the esophagus. JX, LW, YH 反酸 10066872 acid reflux AE Jugular phlebectasia AE is a vasodilatation AE that is an isolated saccular or fusiform dilation of a vein without tortuosity. JX, LW, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708235/ 颈静脉扩张 jugular phlebectasia AE Laryngeal edema AE is an edema AE that shows abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions. JX, LW, YH, MW laryngeal oedema AE 喉肿胀 10023838 laryngeal edema AE CTCAE:E13393 NCIt:C79607 Flatus AE is a digestive system AE that shows gas or air expelled through the anus. JX, LW, YH 排气 10016769 flatus AE Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is constantly. JX, LW, YH 连续性多形性室性心动过速 continuous polymorphic ventricular tachycardia AE Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is intermittent. JX, LW, YH 间歇性多形性室性心动过速 intermittent polymorphic ventricular tachycardia AE Aggravated ulcer AE is a ulcer AE that shows aggravated ulcer. JX, LW, YH 溃疡加重 aggravated ulcer AE Heart failure increased AE is a cardiovascular disorder AE that shows aggravated heart failure. JX, LW, YH 心脏衰竭加重 heart failure increased AE Aggravated angina symptoms AE is a angina pectoris AE that shows aggravated angina symptoms. JX, LW, YH 心绞痛症状加剧 aggravated angina symptoms AE Aggravated renal injury AE is a renal impairment AE that shows aggravated renal injury. JX, LW, YH 肾损害加剧 aggravated renal injury AE Aggravated fatigue AE is a fatigue AE that shows aggravated fatigue. JX, LW, YH 脱力感加重 aggravated fatigue AE Persistent nausea AE is a nausea AE that shows constant nausea. Nausea is considered "persistent" if it continues for more than 2 days, or keeps recurring even after treatment. JX, LW, YH WEB: http://www.all4naturalhealth.com/persistent-nausea.html 持续恶心 persistent nausea AE Aggravated Raynaud's syndrome AE is a Raynaud's syndrome AE that shows aggravated Raynaud's syndrome. JX, LW, YH Raynaud综合征加重 aggravated Raynaud's syndrome AE Increased gastric acid secretion with high dose AE is a gastric disorder AE that shows increased gastric acid secretion with high dose. JX, LW, YH 高剂量时胃酸分泌增加 increased gastric acid secretion with high dose AE Persistent vomiting AE is a vomiting AE that occurs frequently throughout the day and is often triggered by even small meals. JX, LW, YH WEB: http://www.healthhype.com/persistent-and-recurrent-vomiting-emesis-in-adults-and-children.html 持续呕吐 10034716 persistent vomiting AE Hypoacusis AE is a hearing disorder AE that shows partial or complete loss of the ability to detect or understand sounds resulting from damage to the outer, middle, or inner ear structures. Causes include exposure to loud noise, ear infections, injuries to the ear, genetic, and congenital disorders. JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/hypoacusis 突发听力减退 10048865 hypoacusis AE Lip cyanosis AE is a cyanosis AE that is a condition in which the lips have a bluish discoloration due to a lack of oxygen in the tissues. JX, LW, YH WEB: http://www.rightdiagnosis.com/sym/lip_cyanosis.htm 嘴唇发紫 lip cyanosis AE Nail cyanosis AE is a cyanosis AE that shows a dark bluish or purple nail resulting from deficient oxygenation of the blood. JX, LW, YH 指甲青紫 nail cyanosis AE Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia. This term appears to be a synonym to the 'renal failure AE'. JX, LW, YH hepatic and renal function disorder AE 肾功能障碍 renal insufficiency AE UMLS ID: C0859242 JX, LW, YH Hemolysis AE is a hematopoietic system AE that is the rupturing of erythrocytes (red blood cells) and the release of their contents (cytoplasm) into surrounding fluid. WEB: http://en.wikipedia.org/wiki/Hemolysis 溶血 10019491 hemolysis AE CTCAE: E10037 NCIt: C37965 Lip angioedema AE is a angioedema AE that shows lip angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues. JX, LW, YH 唇血管神经性水肿 lip angioedema AE Tongue angioedema AE is a angioedema AE that shows tongue angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues. JX, LW, YH 舌血管神经性水肿 tongue angioedema AE Acousma AE is a sensory capability AE that shows a hallucinatory impression of strange sounds. JX, LW, YH 幻听 acousma AE Eye burning AE is a eye AE that shows a feeling of burning in the eye. JX, LW, YH 眼睛灼烧感 eye burning AE Worsening renal function AE is a kidney AE that shows worsening renal function. JX, LW, YH 肾功能恶化 worsening renal function AE Mild change of hematology AE is a change of hematology AE that shows mild change of hematology. JX, LW, YH 轻度的血液学改变 mild change of hematology AE Moderate change of hematology AE is a change of hematology AE that shows moderate change of hematology. JX, LW, YH 中度的血液学改变 moderate change of hematology AE Severe lower blood pressure AE is a hypotension AE that shows severe sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH significantly decreased blood pressure AE 严重的血压降低 severe lower blood pressure AE Elevated blood transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly. JX, LW, YH 血氨基转移酶可逆性升高 elevated blood transaminase reversibility AE Mild gastrointestinal tract reaction AE is a gastrointestinal disorder AE that shows a mild gastrointestinal disorder. JX, LW, YH 轻度胃肠道反应 mild gastrointestinal tract reaction AE Temporary abdominal distention AE is a abdominal distension AE that shows a temporary sensation of elevated abdominal pressure and volume. JX, LW, YH 暂时性腹胀 temporary abdominal distention AE Transient nausea AE is a nausea AE that is a gastric discomfort associated with the inclination to vomit. JX, LW, YH 暂时性恶心 transient nausea AE Persistent tachycardia AE is a tachycardia AE that is an increased heart rate that exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual). It's a constant process. JX, LW, YH 持续心动过速 persistent tachycardia AE Mild headache AE is a headache AE that shows mild headache. JX, LW, YH 轻度头痛 mild headache AE Transient hypoxemia AE is a hypoxia AE that is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases. JX, LW, YH 瞬态低氧血症 transient hypoxemia AE Transient neuroticism AE is a neuroticism AE that is a type of personality trait that contrasts adjustment or emotional stability with maladjustment. Experience of anxiety, anger, disgust, sadness, embarrassment, and a variety of other negative emotions. JX, LW, YH 瞬态神经质 transient neuroticism AE Constant irritability AE is a irritability AE that shows in the patient being easily annoyed/irritated constantly. JX, LW, YH 持续烦躁 constant irritability AE Abnormal atony AE is a asthenia AE that is a medical term denoting symptoms of physical weakness and loss of strength. JX, LW, YH 异常无力 abnormal atony AE Secondary hypotension AE is a hypotension AE that is a type of hypertension which by definition is caused by an identifiable underlying secondary cause. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Secondary_hypertension 继发性高血压 secondary hypotension AE Transient elevated serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase transiently. JX, LW, YH 瞬时血清转氨酶升高 transient elevated serum transaminase AE Transient elevated blood urea nitrogen AE is a blood urea level increased AE that shows a transient increase in amount of urea in blood. JX, LW, YH 瞬时血尿素氮升高 transient elevated blood urea nitrogen AE Apparent increased blood creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an apparent increased level of creatine phosphokinase or phosphocreatine kinase. JX, LW, YH 明显的血肌酸磷酸激酶增高 apparent increased blood creatine phosphokinase AE Severe rhabdomyolysis AE is a rhabdomyolysis AE that shows in severe damaged skeletal muscle tissue breaks down rapidly. JX, LW, YH 严重的横纹肌溶解症 severe rhabdomyolysis AE Mild gastrointestinal bleeding AE is a gastrointestinal hemorrhage AE that shows mild gastrointestinal hemorrhage. JX, LW, YH 胃肠道轻微出血 mild gastrointestinal bleeding AE Occult gastrointestinal tract bleeding AE is a gastrointestinal hemorrhage AE that shows occult gastrointestinal hemorrhage. JX, LW, YH 胃肠道隐匿性出血 occult gastrointestinal tract bleeding AE Nitrate headache AE is a headache AE that that is a special headache induced by nitrate. JX, LW, YH 硝酸盐性头痛 nitrate headache AE Pantomorphia erythema exudativum AE is a skin AE that is a skin condition of unknown cause, possibly mediated by deposition of immune complex (mostly IgM) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. It is an uncommon disorder, with peak incidence in the second and third decades of life. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Erythema_multiforme 多形性渗出性红斑 pantomorphia erythema exudativum AE High hypodynamia AE is a fatigue AE that is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. JX, LW, YH 高度乏力 high hypodynamia AE Short-time nausea AE is a nausea AE that shows a gastric discomfort associated with the inclination to vomit. JX, LW, YH 短暂的恶心 short-time nausea AE Slightly increased aspartic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of AST which is an enzyme normally present in body tissues especially of the heart and liver, JX, LW, YH 门冬氨酸氨基转移酶轻度升高 slightly increased aspartic transaminase AE Slightly increased alanine aminotransferase AE is a alanine aminotransferase level increased AE that shows elevated levels of alanine transaminase slightly. JX, LW, YH 丙氨酸氨基转移酶轻度升高 slightly increased alanine aminotransferase AE Slightly increased lactic dehydrogenase AE is a blood lactate dehydrogenase level increased AE that shows a slightly increased amount of LDH which is an enzyme that could indicate tissue damage. JX, LW, YH 乳酸脱氢酶轻度升高 slightly increased lactic dehydrogenase AE Slightly increased alkaline phosphatase AE is a blood alkaline phosphatase increased AE that shows elevated levels of alkaline phosphatase slightly. JX, LW, YH 碱性磷酸酶轻度升高 slightly increased alkaline phosphatase AE Slightly increased glutamic-oxalacetic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of glutamic-oxalacetic transaminase in the heart and liver. JX, LW, YH 谷草转氨酶轻度升高 slightly increased glutamic-oxalacetic transaminase AE Slightly increased glutamic pyruvic transaminase AE is a alanine aminotransferase level increased AE that shows eelevated levels of glutamic pyruvic transaminase in the liver. JX, LW, YH 谷丙转氨酶轻度升高 slightly increased glutamic pyruvic transaminase AE Transient ischemic stroke AE is a ischemic stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain. JX, LW, YH 暂时性缺血性中风 transient ischemic stroke AE Evidently increased hepatic lipase AE is a hepatic enzyme increased AE that shows an evidently increase in amount of hepatic enzyme in body, commonly includes ALT and AST. It may indicate inflammation or damage to liver cells. JX, LW, YH 肝酶显著增加 evidently increased hepatic lipase AE Mild decline in blood pressure AE is a hypotension AE that shows mild sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 血压轻度下降 mild decline in blood pressure AE Transient cerebral ischemic attacks AE is a cerebral ischemia AE that shows the sudden death of brain cells in a localized area due to inadequate blood flow. JX, LW, YH 短暂脑缺血发作 transient cerebral ischemic attacks AE Transient hypotension AE is a hypotension AE that shows transient sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 瞬时低血压 transient hypotension AE Obviously decreased blood pressure AE is a hypotension AE that shows obviously sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH significantly decreased blood pressure AE 血压明显下降 obviously decreased blood pressure AE Transient dizzy AE is a dizziness AE that shows transient dizziness. JX, LW, YH 瞬时头晕 transient dizzy AE Short-time hepatic function disorder AE is a hepatic function abnormal AE that shows a short-time abnormal functionality of the liver. JX, LW, YH 短暂肝功能异常 short-time hepatic function disorder AE A slightly elevated plasma creatinine level AE is a blood creatinine level increased AE that shows an slightly increased level of creatinine in the blood (due to lack of kidney activity). JX, LW, YH 血浆肌酐水平的轻微升高 a slightly elevated plasma creatinine level AE Sudden fall of blood pressure AE is a hypotension AE that shows sudden sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 血压突然降低 sudden fall of blood pressure AE Severe hypertension AE is a hypotension AE that shows severe sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 严重高血压 severe hypertension AE Severe arrhythmia AE is an arrhythmia AE that shows severe abnormal heart rhythm. JX, LW, YH 严重心律失常 severe arrhythmia AE Clinically significant rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly. JX, LW, YH 血清转氨酶有临床显著升高 clinically significant rise of serum transaminase AE Instantaneous sand-blind AE is a vision blurred AE that shows in instantaneous unclear vision. JX, LW, YH 瞬时视觉模糊 instantaneous sand-blind AE Moderately increased urinary nitrogen AE is a blood urea level increased AE that shows a moderately increase in amount of urea in blood. JX, LW, YH 尿素中度升高 moderately increased urinary nitrogen AE Slightly increased urinary nitrogen AE is a blood urea level increased AE that shows a slightly increase in amount of urea in blood. JX, LW, YH 尿素水平轻微升高 slightly increased urinary nitrogen AE Moderately elevated serum creatinine AE is a blood creatinine level increased AE that shows an moderately increased level of creatinine in the blood (due to lack of kidney activity). JX, LW, YH 血肌酐中度升高 moderately elevated serum creatinine AE Slightly increased aminotransferase AE is a transaminase level increased AE that shows slightly elevated levels of alanine transaminase and aspartate transaminase. JX, LW, YH 轻度氨基转氨酶升高 slightly increased aminotransferase AE Severe dizziness AE is a dizziness AE that shows severe dizziness. JX, LW, YH 严重眩晕 severe dizziness AE Mild abdominal discomfort AE is a abdominal discomfort AE that shows a mild stomach ache. JX, LW, YH 轻微腹部不适 mild abdominal discomfort AE A blood potassium decreased quality where the amount of potassium in the blood is moderately decreased. JX, LW, YH, MW 血清钾浓度的轻度降低 serum potassium concentration of moderately reduced Rebound Increased blood pressure AE is a hypertension AE that shows rebound sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 反跳性血压升高 rebound Increased blood pressure AE Excessive lowering of blood pressure AE is a hypotension AE that shows excessive sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 血压过度降低 excessive lowering of blood pressure AE Short-time increased blood sugar AE is a blood glucose level increased AE that shows a short-time increased glucose level in blood. JX, LW, YH 短暂血糖升高 short-time increased blood sugar AE Mild nausea AE is a nausea AE that shows mild nausea. JX, LW, YH 轻度恶心 mild nausea AE Significant and persistent rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently. JX, LW, YH 血清氨基转移酶显著和持续性升高 significant and persistent rise of serum transaminase AE Elevated serum transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly. JX, LW, YH 血清氨基转移酶可逆性升高 elevated serum transaminase reversibility AE Reversible increased creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an reversible increased level of creatine phosphokinase or phosphocreatine kinase. JX, LW, YH 肌酸磷酸激酶可逆性升高 reversible increased creatine phosphokinase AE Persistent and significant increase of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently. JX, LW, YH 血清转氨酶显著和持续性升高 persistent and significant increase of serum transaminase AE Severe bradycardia AE is a bradycardia AE that shows in a resting heart rate of under 60 beats per minutes (BPM). JX, LW, YH 严重心动过缓 severe bradycardia AE Apparent hypotensive reaction AE is a hypotension AE that shows apparent sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 显著的低血压反应 apparent hypotensive reaction AE Severe skin flush AE is a hot flush AE that shows severe hot flush. JX, LW, YH 显著皮肤潮红 severe skin flush AE Transient sinus cardiac arrest AE is a sinus arrest AE that shows an electrocardiographic finding of transient impulse formation failure in the sinus node. JX, LW, YH 瞬时窦性停搏 transient sinus cardiac arrest AE Low-grade gastralgia AE is a stomacheache AE that shows a low-grade painful sensation in the stomach. JX, LW, YH 轻度胃痛 low-grade gastralgia AE Severe headache AE is a headache AE that shows severe headache. JX, LW, YH 严重头痛 severe headache AE Persistent headache AE is a headache AE that shows persistent headache. JX, LW, YH 持续头痛 persistent headache AE Proarrhythmic effect AE is an arrhythmia AE that is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias. JX, LW, YH arhythmia auxo-action AE WEB: http://en.wikipedia.org/wiki/Proarrhythmia 致心律失常 10036766 proarrhythmic effect AE a metabolism, endocrine, and exocrine system AE that has an outcome of acidosis, i.e., too much acid in the body fluids. Blood pH Decreased URL: http://www.nlm.nih.gov/medlineplus/ency/article/001181.htm 10000486 10005706 YH, SJ, MW acidosis AE CTCAE:E12237 NCIt:C28228 Increased tendency of biliary calculus AE is a liver, biliary, and pancreatic AE that shows an increased tendency of biliary calculus. JX, LW, YH 胆石增加的趋势 increased tendency of biliary calculus AE Temporarily lose consciousness AE is a sensory capability AE that shows temporarily lose consciousness. JX, LW, YH 暂时失去知觉 temporarily lose consciousness AE Increase breast cancer occurrence AE is a breast cancer AE that shows increase breast cancer occurrence. JX, LW, YH 乳腺癌发生增加 increase breast cancer occurrence AE Anticholinergic effect AE is a conduction system disorder AE that is physical symptoms resulting from agents that counter the action of acetylcholine, a neurotransmitter (chemical within the nervous system) that is involved in many major bodily functions. These anticholinergic effects typically include constipation, dry mouth, blurred vision, dizziness, and slowing of urination. JX, LW, YH WEB: http://ibs.about.com/od/glossary/g/Anticholeffect.htm 经讯号传导阻断效应 anticholinergic effect AE a musculoskeletal system AE that has an outcome of diaphragmatic muscle replaced by fibroelestic tissue. The diaphragm retains its continuity and attachments to the costal margin. However, the weakened hemidiaphragm is displaced into the thorax, which can compromise breathing. SJ, YH URL: http://www.uptodate.com/contents/eventration-of-the-diaphragm-in-infants 10000486 acquired diaphragmatic eventration AE Neutrophilopenia AE is a neutrophil count decreased AE that shows the number of neutrophil is decreased. JX, LW, YH 中性白细胞减少 neutrophilopenia AE Abnormal leucocyte neutrophil AE is a neutrophil percentage abnormal AE that shows abnormal leucocyte neutrophil. JX, LW, YH 嗜中性白细胞异常 abnormal leucocyte neutrophil AE Abnormal eosinocyte AE is an eosinophil count abnormal AE that shows abnormal eosinocyte. JX, LW, YH 嗜酸性粒细胞异常 abnormal eosinocyte AE Eosinopenia AE is an eosinophil count abnormal AE that is a form of agranulocytosis where the number of eosinophil granulocytes is lower than expected. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Eosinopenia 嗜酸细胞减少症 10014940 eosinopenia AE Aggravated peptic ulcer AE is a duodenal ulcer AE that shows aggravated peptic ulcer. JX, LW, YH 消化性溃疡加重 aggravated peptic ulcer AE Local tissue necrosis AE is a necrosis AE that shows local tissue necrosis. JX, LW, YH 局部组织坏死 local tissue necrosis AE a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by diminished blood supply to the heart SJ, YH URL: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/acute-myocardial-infarction/ 10000891 acute myocardial infarction AE an endocrine system AE that results in a life threatening condition due to a lack of cortisol produced by the adrenal glands SJ, YH URL: http://www.nlm.nih.gov/medlineplus/ency/article/000357.htm 10001389 acute adrenal crisis AE YH, SJ URL http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2814%2970102-4/abstract 10053552 a pain AE that results in pain from a stimulus that does not usually provoke pain allodynia AE an embolism AE in which amniotic fluid, fetal cells, hair or other debris enter the maternal circulation resulting in cardiorespiratory collapse SJ, YH Anaphylactoid Syndrome of Pregnancy WEB: http://emedicine.medscape.com/article/253068-overview 10001977 amniotic fluid embolism AE a muscular weakness AE that has an outcome of weakness followed by wasting of muscles, and excruciating pain in the muscles of the thigh, hip, and buttocks YH, SJ diabetic lumbosacral radiculoplexus neuropathy diabetic polyradiculoneuropathy proximal diabetic neuropathy 10002027 diabetic amyotrophy AE an adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment SJ, YH WEB: https://www.dha.gov.ae/EN/Facilities/Hospitals/RashidHospital/SpecializedMedicalService/ClinicalServices/Anesthesiologyandinterventionalpain/pages/sideeffects.aspx 10060938 anesthetic complication AE an anus AE that results in the development of a small channel between the end of the bowel and the skin near the anus SJ, YH WEB: http://www.webmd.boots.com/digestive-disorders/anal-fistula 10002156 anal fistula AE CTCAE: E10464 NCIt: C60785 postoperative anemia AE is an anemia AE that occurs when a patient with acute bleeding loses enough blood to become anemic SJ, YH bleeding and acute blood loss anemia WEB: http://www.acphospitalist.org/archives/2012/02/coding.htm 10054312 postoperative anemia AE a behavior and neurological AE that results in antagonism toward someone or something you feel has deliberately done you wrong: excessive anger can cause problems including increased blood pressure and other physical changes that make it difficult to think straight and can harm your physical and mental health. SJ, YH WEB: http://apa.org/topics/anger/index.aspx 10002368 anger AE a musculoskeletal system AE that results in the formation of fibrous band between tissues and organs, often as a result of injury during surgery SJ, YH URL: http://en.wikipedia.org/wiki/Adhesion_%28medicine%29 10059837 adhesion AE a crying abnormal AE that refers to a neurologic disorder characterized by involuntary crying or uncontrollable episodes of crying and/or laughing, or other emotional displays YH, SJ emotional incontinence emotional lability labile affect WEB: http://en.wikipedia.org/wiki/Pseudobulbar_affect 10054196 pseudobulbar affect AE cardiovascular AE that results in disease of the arteries, veins, and capillaries SJ, YH macroangiopathy microangiopathy WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853 10059245 angiopathy AE a cardiovascular AE that results in the walls of small blood vessels becoming so thick and weak that they bleed, leak protein, and slow the flow of blood SJ, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853 10062198 microangiopathy AE a cardiovascualr AE that results in the build up of fat and blood clots in the large blood vessels, stick to the vessel walls, and block the flow of blood SJ, YH cerebrovascular disease coronary artery disease peripheral vascular disease WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853 10054805 macroangiopathy AE a muscle AE that results in a congenital anomaly in which a short, lingual frenulum or a highly-attached genioglossus muscle restricts tongue movement SJ, YH tongue-tie WEB: http://www.uptodate.com/contents/ankyloglossia-tongue-tie-in-infants-and-children 10049244 ankyloglossia AE a digestive system AE that results in a group of medical disorders that occur at the junction of the anal canal and the rectum SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/Anorectal+Disorders 10002644 anorectal disorder AE a hemorrhage AE that has an outcome of bleeding from or in to the genital tract, occurring from 24 weeks of pregnancy and prior to the birth of the baby. YH, SJ WEB: https://www.rcog.org.uk/globalassets/documents/guidelines/gtg63_05122011aph.pdf 10055228 antepartum hemorrhage AE Brain damage AE that results in a persistent vegetative state SJ, YH WEB: http://www.rightdiagnosis.com/a/apallic_syndrome/intro.htm 10002941 apallic syndrome AE APGAR is a quick test performed on a neonate at 1 and 5 minutes after birth. The 1-minute score determines how well the baby tolerated the birthing process. The 5-minute score tells the doctor how well the baby is doing outside the mother's womb. Any score lower than 7 is a sign that the baby needs medical attention. The lower the score, the more help the baby needs to adjusting outside the mother's womb YH, SJ WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003402.htm 10002944 10062552 APGAR score low AE a brain disorder AE that causes a person to lose the ability to communicate. Aphasia can affect the ability to express and understand language, both verbal and written. Aphasia typically occurs suddenly after a stroke or a head injury, but it can also come on gradually from a slowly growing brain tumor or a degenerative disease SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/aphasia/basics/definition/con-20027061 10002948 aphasia AE a tumor AE that results in pouches of cerebrospinal fluid covered by arachnoidal cells and collagen that may develop between the surface of the brain and the cranial base or on the arachnoid membrane SJ, YH WEB:http://en.wikipedia.org/wiki/Arachnoid_cyst 10049005 arachnoid cyst AE a brain disorder AE that causes inflammation of the arachnoid, one of the membranes known as meninges that surround and protect the nerves of the central nervous system, including the brain and spinal cord. SJ, YH, MW WEB: http://en.wikipedia.org/wiki/Arachnoiditis 10003074 arachnoiditis AE CTCAE:E12591 NCIt:C37913 A pregnancy AE that results in an interruption in the labor process that is associated with uterine contractions. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/arrested+labor 10003118 arrested labor AE an arrhythmia AE that is characterized by shortness of breath, heart palpitations, chest tightness, and a very fast pulse. Supraventricular arrhythmias begin in the areas above the heart’s lower chambers, such as the upper chambers (the atria) or the atrial conduction pathways. SJ, YH atrial arrhythmia WEB: http://www.texasheart.org/HIC/Topics/cond/arrhycat.cfm 10003130 supraventricular arrhythmia AE a cardiac disorder AE which causes a spasm of the large- or medium-sized coronary arteries SJ, YH coronary artery spasm coronary artery vasospasm coronary vasospasm WEB: http://sideeffects.embl.de/se/C0010073/pt 10003225 coronary arteriospasm AE joint range of motion decreased AE caused by an excessive amount of scar tissue forming within the joint and surrounding soft tissue spaces SJ, YH WEB: http://en.wikipedia.org/wiki/Arthrofibrosis 10058029 arthrofibrosis AE arteriosclerosis AE is a cardiovascular AE that results in blood vessels and arteries becoming thick and stiff which can restrict blood flow to organs and tissues. SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972 10003210 arteriosclerosis AE atheroslcerosis AE is a specific arteriosclerosis AE that refers to the buildup of fats, cholesterol and other substances in and on artery walls which can restrict blood flow. SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972 10003601 atherosclerosis AE atrial tachycardia AE is a tachycardia AE that results in a fast heart rate beginning in the upper chambers of the heart SJ, YH paroxysmal atrial tachycardia paroxysmal supraventricular tachycardia supraventricular tachycardia WEB: http://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/Tachycardia-Fast-Heart-Rate_UCM_302018_Article.jsp# 10003668 10034040 atrial tachycardia AE CTCAE: E10166 NCIt: C34900 a hematology investigation result abnormal AE that results in high blood cortisol levels SJ, YH URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm 10005458 blood cortisol decreased AE may indicate that the patient has cushing disease, ectopic cushing syndrome, or a tumor of the adrenal gland that is producing too much cortisol. blood cortisol increased AE a cardiovascular disorder AE that results in easy or excessive bruising and bleeding. The bleeding results from unusually low levels of platelets. SJ, YH immune thrombocytopenic purpura WEB: http://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/basics/definition/con-20034239 10050245 idiopathic thrombocytopenic purpura AE YH, SJ WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2477 10005063 a pain AE that is observed in the bladder, usually a symptom of bladder infection. bladder pain AE an eye AE that results in involuntary, forcible closure of the eyelids.The spasms may leave the eyelids completely closed, causing functional blindness even though the eyes and vision are normal. SJ, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2481 10005159 blepharospasm AE an abnormal vision AE which has an outcome of loss of vision in one eye that is not permanent. SJ, YH blindness unilateral WEB: http://en.wikipedia.org/wiki/Amaurosis_fugax 10005186 amaurosis fugax AE a hematology investigation result abnormal AE that results in low blood cortisol levels SJ, YH URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm 10005457 blood cortisol decreased AE may indicate that the patient has addison disease, hypopituitarism, suppression of normal pituitary or adrenal function. blood cortisol decreased AE a hematology investigation result abnormal AE that results in high blood creatine levels SJ, YH URL: http://www.mayoclinic.org/tests-procedures/creatinine/basics/definition/prc-20014534 10005464 blood creatine increased AE may indicate that the kidneys are not fucntioning properly blood creatine increased AE a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly YH, SJ 10005971 bone graft procedure a hematology investigation result abnormal AE that signifies that a patient is allergic to a particular substance SJ, YH WEB: http://kidshealth.org/parent/system/medical/test_ige.html 10005591 blood immunoglobin E increased AE a hematology investigation result abnormal AE that results in low levels of testosterone which can lead to infertility and a low sex drive SJ, YH WEB: http://www.webmd.com/men/testosterone-15738 10005814 blood testosterone decreased AE A macrocytic anemia AE is an anemia AE that has an outcome of a macrocytic anemia, which is an anemia (defined as blood with an insufficient concentration of hemoglobin) in which the red blood cells (erythrocytes) are larger than their normal volume. KM, YH WEB: http://en.wikipedia.org/wiki/Macrocytic_anemia 10002064 macrocytic anemia AE a bone disorder AE that has an outcome of low bone densityl, but not low enough to be considered osteoporosis SJ, YH WEB: http://nof.org/articles/9 10049470 low bone density AE a surgical AE that occurs after a bone graftr procedure, which replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly. SJ, YH WEB: http://en.wikipedia.org/wiki/Bone_grafting bone graft AE bone marrow edema AE is an edema AE that occurs when excess fluids in the bone marrow buildup and cause swelling. This condition is often caused by a protective reaction of the body in response to an injury or inflammation SJ, YH WEB: http://www.wisegeek.com/what-is-bone-marrow-edema.htm 10051763 bone marrow edema AE an investigation result abnormal AE that detects areas of increased or decreased bone activity. These may indicate bone injury or disease. SJ, YH WEB: http://www.mountsinai.org/patient-care/health-library/treatments-and-procedures/bone-scan 10061941 bone scan abnormal AE Nervous system AE that covers a variety of conditions that may impair function of the brachial plexus nerve network, most of which are caused by trauma. SJ, YH WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/peripheral_nerve_surgery/conditions/brachial_plexus_injury_bpi.html 10006074 brachial plexus injury AE a bradycardia AE that results in a disturbance in the heart rhythm in which the heart rate is abnormally slowed. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/bradyarrhythmia 10049765 bradyarrhythmia AE a bradycardia AE that results in a fetal heart rate of less than 120 beats per minute, generally associatedwith hypoxia SJ, YH WEB:http://medical-dictionary.thefreedictionary.com/fetal+bradycardia 10006094 bradycardia fetal AE a brain disorder AE that results in the complete and irreversible loss of brain function SJ, YH WEB: http://en.wikipedia.org/wiki/Brain_death 10049054 brain death AE a brain disorder AE that results in brain tissue, cerebrospinal fluid, and blood vessels being moved or pressed away from their usual position inside the skull. SJ, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001421.htm 10006126 brain herniation AE a brain injury AE,  injury to the brain caused by an external force, that results in a brain AE SJ, YH Traumatic Brain Injury WEB: http://www.biausa.org/FAQRetrieve.aspx?ID=43913 10067967 brain injury AE a brain mass AE is a mass or growth of abnormal cells in your brain or close to your brain SJ, YH Brain Neoplasm Brain Tumor Intercranial Neosplasm WEB: http://www.mayoclinic.org/diseases-conditions/brain-tumor/home/ovc-20117132 10052334 10061019 brain mass AE an imaging investigation result abnormal AE shows how the brain and its tissues are working. Abnormal results may be due to: Alzheimer’s disease or dementia, brain tumors, epilepsy, and movement disorders. SJ, YH PET scan WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007341.htm 10061943 brain scan abnormal AE Eyelid disorder AE is a eye AE that is a condition specifically affects the eyelid. It can include drooping, twitching, inflammation, paralysis, and growths. Occasional fluttering of one eyelid is normal. JX, LW WEB: http://www.healthline.com/health/eyelid-disorders#Overview1 10061130 eyelid disorder AE Hepatic steatosis AE is a liver disorder AE than popularly called as ‘fatty liver’ is a pathological aspect of liver, whose specific cells (hepatocytes) are filled with lipids (fats). It is a reversible liver disease: ‘is not still very ill, but cries for help’. JX, LW WEB: http://www.bendomd.com/272-hepatic-steatosis-causes-symptoms-treatment.html 10019708 hepatic steatosis AE An arthropathy AE is a joint pain AE that has an outcome of arthropahty, which is any disorder of the joints. This is an AE which is an injury to the abdomen and its signs and symptoms include abdominal pain, tenderness, rigidity, and bruising of the external abdomen. KM, YH QY, JX, HY WEB: http://en.wikipedia.org/wiki/Arthropathy, http://medical-dictionary.thefreedictionary.com/arthropathy http://en.volupedia.org/wiki/Abdominal_trauma 腹部损伤 10003285 10060924 abdominal injury AE arthropathy AE NCIT: C35760 A balantis AE is a reproductive system AE that has an outcome of a balantis, which is an infectious or non-infectious inflammatory process that affects the glans penis. Symptoms include redness and pain of the glans penis and foreskin and discharge. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000862.htm, http://en.wikipedia.org/wiki/Balanitis 10004073 balanitis AE Pruritus genital AE is a pruritus AE that also called genital itching, Itching in the genital region can result from irritation, allergy, inflammation, infection or cancer. Irritation can occur as a result of exposure to chemicals in soaps, feminine hygiene products, perfumes, lubricants, douches, and creams. JX, LW genital itching AE WEB: http://www.healthgrades.com/symptoms/genital-itching 10037093 pruritus genital AE cholecystitis AE is an gallbladder enlargement AE that has an outcome of cholecystitis, which is an acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones. KM, YH WEB: http://en.wikipedia.org/wiki/Cholecystitis, http://www.mayoclinic.org/diseases-conditions/cholecystitis/basics/definition/con-20034277 10008612 cholecystitis AE CTCAE: E11184 NCIT: C34465 NCIt: C34465 Chromaturia AE is an urine abnormality AE that has an outcome of chromaturia, which is an abnormal coloration of the urine. KM, YH WEB: http://medical-dictionary.thefreedictionary.com/chromaturia 10008796 chromaturia AE Chromosome abnormality AE is a genetic AE that has an outcome of chromsome abnormality which is a missing, extra, or irregular protion of chromosomal DNA. KM, YH WEB: http://en.wikipedia.org/wiki/Chromosome_abnormality 10008815 chromosome abnormality AE A coagulopathy AE is a blood disorder AE that has an outcome of coagulopathy, which is a condition in which there is a deviation from or interruption of the normal coagulation properties of the blood. KM, YH WEB: http://en.wikipedia.org/wiki/Coagulopathy 10009802 coagulopathy AE Combined immunodeficiency AE is an immune system AE that has an outcome of combined immunodeficiency, which represents a group of rare, sometimes fatal, congenital disorders characterized by little or no immune response. KM, YH WEB: http://www.ncbi.nlm.nih.gov/books/NBK22254/ 10010099 combined immunodeficiency AE Hepatic enzyme abnormal AE is a liver related investigation result abnormal AE that the lab test result of hepatic enzyme deviates from its normal value. JX, YH 10062685 hepatic enzyme abnormal AE A coronary artery aneurysm AE is a coronary artery disorder AE that has an outcome of coronary artery aneurysm, which is a coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times. KM, YH WEB: http://en.wikipedia.org/wiki/Coronary_artery_aneurysm WEB: http://www.ncbi.nlm.nih.gov/pubmed/9247557 10011071 coronary artery aneurysm AE Injection site atrophy AE is an injection-site AE that muscle atrophy occur in the injection site. JX, YH 10022048 injection site atrophy AE A cutaneous tuberculosis AE is a tuberculosis AE that has an outcome of cutaneous tuberculosis, which is an invasion of the skin by Mycobacterium tuberculosis. KM, YH WEB: http://www.dermnetnz.org/bacterial/tuberculosis.html 10011684 cutaneous tuberculosis AE Breath sounds abnormal AE is a respiratory system AE that is characterized by abnormal breath sound, it can indicate fluid in the lungs or asthma. JX, LW WEB: http://www.healthline.com/health/breath-sounds#Overview1 10064780 breath sounds abnormal AE Skin abrasion AE is a skin AE that is a wound caused by superficial damage to the skin, no deeper than the epidermis. JX, YH WEB: http://en.wikipedia.org/wiki/Abrasion_%28medical%29 10064990 skin abrasion AE Trigeminal neuralgia AE is a neuralgia AE that is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. The clinical association between TN and hemifacial spasm is the so-called tic douloureux. JX, YH Fothergill's disease AE prosopalgia AE WEB: http://en.wikipedia.org/wiki/Trigeminal_neuralgia 10044652 trigeminal neuralgia AE Face injury AE is an injury AE that injury occurs in the face. JX, YH 10050392 face injury AE Muscle contrature AE is a muscle AE that can occur for many reasons, such as paralysis, muscular atrophy, and forms of muscular dystrophy. Fundamentally, the muscle and its tendons shorten, resulting in reduced flexibility. JX, YH WEB: http://en.wikipedia.org/wiki/Muscle_contracture 10062575 muscle contrature AE A palsy AE that has a symmetric limitation of the movements of both eyes in the same direction. JX, YH WEB: http://one.aao.org/bcscsnippetdetail.aspx?id=f5a77965-de2a-4fb0-82fb-5f4089671ad6 10056696 gaze palsy AE Conjugate gaze palsy AE is a gaze palsy AE that is a disorder affecting the ability to move both eyes in the same direction. These palsies can affect gaze in a horizontal, upward, or downward direction. JX, YH WEB: http://en.wikipedia.org/wiki/Conjugate_gaze_palsy conjugate gaze palsy AE Horizontal gaze palsy AE is a gaze palsy AE that is the paresis of conjugate eye movements. JX, YH WEB: http://en.wikipedia.org/wiki/Horizontal_gaze_palsy horizontal gaze palsy AE a behavioral and neurological AE that refers to rigid body movements and chronic abnormal positions of the body. This symptom is not the same as showing poor posture or slumping over. Rather, it is often the result of a serious spinal cord or brain injury. JX, YH WEB: http://www.healthline.com/symptom/posture-abnormal 10036436 posture abnormal AE a behavioral and neurological AE that shows the body becomes entire rigid and uncontrolled jerking. They may last mere seconds, or continue for several minutes. JX, YH 10051171 tonic clonic movements AE Eyelid ptosis AE is an eye disorder AE that is a drooping or falling of the upper or lower eyelid. JX, LW WEB: http://en.wikipedia.org/wiki/Ptosis_%28eyelid%29 10015995 eyelid ptosis AE Facial paresis AE is a paresis AE that is a common problem that involves the paralysis of any structures innervated by the facial nerve. JX, YH facial nerve paralysis AE WEB: http://en.wikipedia.org/wiki/Facial_nerve_paralysis 10051267 facial paresis AE Menstrual disorder AE is an abnormal condition in a woman's menstrual cycle. WEB: http://en.wikipedia.org/wiki/Menstrual_disorder 10027327 JX, YH menstrual disorder AE Fluid retention AE is an abnormal fluid regulation AE that is excess fluid that collects in the tissues in your body. Most commonly, fluid retention is marked by swelling of your feet and lower legs, but swelling could also occur in your arms, hands, face, or other areas of the body. JX, YH WEB: http://www.healthgrades.com/symptoms/fluid-retention 10016807 fluid retention AE Emotional distress AE is a emotional disorder AE that is a Mental distress or anxiety suffered as a response to a sudden, severe, and saddening experience. JX, YH WEB: http://en.wikipedia.org/wiki/Emotional_distress 10049119 emotional distress AE Encephalitis AE is a nervous system AE that is an acute inflammation of the brain. JX, YH WEB: http://en.wikipedia.org/wiki/Encephalitis 10014581 encephalitis AE a psychiatric disorder AE that is a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. JX, YH WEB: http://en.wikipedia.org/wiki/Cognitive_disorder 10057668 cognitive disorder AE Incoherent AE is a speech disorder AE that shows unable to express one's thoughts or ideas in an orderly, intelligible manner. JX, YH WEB: http://medical-dictionary.thefreedictionary.com/incoherent 10021630 incoherent AE Exercise tolerance decreased AE is a systematic AE that shows exercise tolerance decreased. The exercise tolerance refers to the exercise capacity of an individual as measured by their ability to endure exercise and/or the maximum work load achieved during the exercise period. JX, YH WEB: http://copd.about.com/od/glossaryofcopdterms/g/activitytoleran.htm 10051301 exercise tolerance decreased AE a burn AE that is a type of burn resulted from making contact with heated objects, such as boiling water, steam, hot cooking oil, fire, and hot objects. JX, LW WEB: http://en.wikipedia.org/wiki/Thermal_burn 10053615 thermal burn AE a psychiatric disorder AE that describes a wide array of experiences from mild detachment from immediate surroundings to more severe detachment from physical and emotional experience. JX, YH WEB: http://en.wikipedia.org/wiki/Dissociation_%28psychology%29 10013457 dissociation AE Acupuncture is the stimulation of specific acupuncture points along the skin of the body using thin needles. It can be associated with the application of heat, pressure, or laser light to these same points. JX, LW WEB: http://en.wikipedia.org/wiki/Acupuncture 10000646 acupuncture Mucous membrane disorder AE is a systematic AE that the diseases occur in mucous membrane, which is a lining of mostly endodermal origin. JX, YH WEB: http://en.wikipedia.org/wiki/Mucous_membrane 10028133 mucous membrane disorder AE a polyneuropathy AE that arises when the myelin sheaths around nerve cells are damaged. Myelin, the insulating layer of tissue that surrounds nerve cells, helps ensure that signals from the brain are rapidly transmitted to the proper places in the body. When myelin is damaged or destroyed, it can lead to problems with communication between the brain and the body. JX, YH WEB: http://www.healthgrades.com/conditions/chronic-inflammatory-demyelinating-polyneuropathy 10061811 demyelinating polyneuropathy AE a syndrome AE that results in increased pressure in a muscle compartment which can lead to nerve damage and impaired blood flow. SJ, YH URL: http://www.nlm.nih.gov/medlineplus/ency/article/001224.htm 10010121 Thick layers of tissue, called fascia, separate groups of muscles in the arms and legs from each other. Inside each layer of fascia is a confined space, called a compartment. The compartment includes the muscle tissue, nerves, and blood vessels. compartment syndrome AE Therapeutic response decreased is found among people who take Cialis, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Aspirin, and have Erection problems. JX, LW WEB: http://www.ehealthme.com/ds/cialis/therapeutic+response+decreased 10043414 therapeutic response decreased Bed rest is a medical treatment in which a person lies in bed for most of some period of time to gain health benefits. JX, LW WEB: http://en.wikipedia.org/wiki/Bed_rest 10050118 bed rest a seizure AE that resutls in impariment of awareness and involuntary but coordinated and repeated movements. YH, SJ WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2 10010145 complex partial seizure AE Autoimmune disorder AE is an immune system AE that arises from an abnormal immune response of the body against substances and tissues normally present in the body (autoimmunity). JX, YH WEB: http://en.wikipedia.org/wiki/Autoimmune_disease 10061664 autoimmune disorder AE CTCAE: E11258 NCIt: C2889 a hemorrhage AE that has an outcome of bleeding into the pons or mesencephalon. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/brainstem+hemorrhage 10006146 brain stem hemorrhage AE is often secondary to brainstem distortion due to rapidly expanding intracranail lessions. brainstem hemorrhage AE Menstruation irregular AE is a endocrine system AE that is an abnormal variation in length of menstrual cycles in a female. JX, YH, MW irregular menstruation AE WEB: http://en.wikipedia.org/wiki/Irregular_menstruation 10022992 10027339 menstruation irregular AE CTCAE: E13125 NCIt: C35219 Generalised tonic-clonic seizure AE is a seizure AE that is a type of generalized seizure that affects the entire brain. Tonic–clonic seizures are the seizure type most commonly associated with epilepsy and seizures in general, though it is a misconception that they are the only type. JX, YH WEB: http://en.wikipedia.org/wiki/Tonic%E2%80%93clonic_seizure 10018100 generalised tonic-clonic seizure AE a psychiatric disorder AE that an involuntary flexion or extension of the arms and legs, indicating severe brain injury. JX, YH WEB: http://en.wikipedia.org/wiki/Abnormal_posturing 10036437 posturing AE Off label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, unapproved dosage, or unapproved form of administration. JX, LW off label use WEB: http://en.wikipedia.org/wiki/Off-label_use 10053762 off label drug use Demyelination AE is a nervous system AE that is any disease of the nervous system in which the myelin sheath of neurons is damaged. JX, YH WEB: http://en.wikipedia.org/wiki/Demyelinating_disease 10012305 demyelination AE Gram stain negative AE is a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-negative bacteria. JX, YH WEB: http://en.wikipedia.org/wiki/Gram-negative_bacteria 10018656 gram stain negative AE Red blood cells CSF positive AE is a CSF test result abnormal AE that has an outcome of CSF red blood cells count positive. JX, YH 10038173 red blood cells CSF positive AE CSF white blood cell count increased AE is a CSF test result abnormal AE that has an outcome of CSF white blood cell count increased. JX, YH 10053805 CSF white blood cell count increased AE Influenza A virus test positive AE is a influenza virus test positive AE that has an outcome of positive result in an influenza A virus test. JX, YH 10070215 influenza A virus test positive AE a behavior and neurological test abnormal AE that shows a abnormal result of nerve conduction study (NCS). NCS is a medical diagnostic test commonly used to evaluate the function, especially the ability of electrical conduction, of the motor and sensory nerves of the human body. JX, YH WEB: http://en.wikipedia.org/wiki/Nerve_conduction_study 10029175 nerve conduction study abnormal AE Myocardial necrosis AE is a cardiac disorder AE that shows death of the cells of an area of the heart muscle (myocardium) as a result of oxygen deprivation, which in turn is caused by obstruction of the blood supply. JX, YH URL: http://medical-dictionary.thefreedictionary.com/myocardial+necrosis 10028602 myocardial necrosis AE a brainstem infarction AE is a stroke AE that occurs when blood cannot flow to the brainstem, when oxygen cannot get to an area of the brain, tissue in that area may be damaged. SJ, YH brainstem stroke WEB: http://en.wikipedia.org/wiki/Brain_stem_stroke_syndrome WEB: http://www.drugs.com/cg/brain-stem-infarction.html 10006147 A person may have vertigo, dizziness and severe imbalance without the hallmark of most strokes – weakness on one side of the body. But dizziness alone is not a sign of stroke. Brain stem stroke can also cause diplopia, slurred speech and decreased level of consciousness. brainstem infarction AE a lung disorder AE that occurs when the noises produced by the structures of the lungs during breathing are decreased or absent. SJ, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007535.htm 10006333 Absent or decreased breath sounds can indicate air or fluid around the lungs, increased thickness of chest wall, over-inflation of part of the lungs, or reduced airflow to part of the lungs. breath sounds decreased AE a syndrome AE that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. SJ, YH sudden adult death syndrome (SADS) WEB: http://en.wikipedia.org/wiki/Brugada_syndrome 10059027 Brugada syndrome AE Buttock pain AE is a pain AE that is a common problem in the butt, it can be due to bursitis, bruising, piriformis syndrome, and shingles,or due to more serious diseases with long-term consequences, such as cancer, arthritis of the sacroiliac joints, and herniated disc with sciatica. SJ, YH, MW Butt Pain WEB:http://www.medicinenet.com/buttock_pain/symptoms.htm 10048677 buttock pain AE CTCAE:E12396 NCIt:C78228 a digestive system AE with an outcome of small white calcium lumps forming under the skin that may leak a chalky white fluid. These lumps are formed becuase of too much calcium in the diet. SJ, YH WEB: http://www.sclero.org/medical/symptoms/skin/calcinosis.html 10006938 These most commonly occur on the hands, or near joints such as elbows or knees, although they may appear anywhere. Calcinosis may range from one very tiny deposit, to large (and often painful) clusters. calcinosis AE an infection adverse event that caused by a species of the yeast Candida. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/candidiasis 10007152 This is a common cause of vaginal infections in women. Also, Candida may cause mouth infections in people with reduced immune function, or in patients taking certain antibiotics. Candida can be found in virtually all normal people but causes problems in only a fraction. candidiasis AE a hematology investigation result abnormal AE that occurs when the cardaic enzymes and proteins leak out of damaged heart muscle cells, and their levels in the bloodstream rise. SJ, YH URL: http://www.webmd.com/heart-disease/cardiac-enzyme-studies 10007548 cardiac enzymes increased AE may indicate that the heart muscle is injured, such as from a heart attack. cardiac enzymes increased AE Acute decompensated heart failure AE is a cardiovascular disorder AE that shows a worsening of the symptoms, typically shortness of breath (dyspnea), edema, and fatigue, in a patient with existing heart disease. SJ, YH Cardiac Failure Acute WEB: http://en.wikipedia.org/wiki/Acute_decompensated_heart_failure 10007556 10064653 acute decompensated heart failure AE Cardiac massage is a resuscitative procedure that employs the rhythmic compression of the chest and heart in an effort to restore and maintain the circulation after cardiac arrest or ventricular fibrillation SJ, YH Heart Massage WEB: http://www.thefreedictionary.com/cardiac+massage 10059163 cardiac massage Cardiac murmur AE is a cardiac disorder AE that is characterised by abnormal sounds during the heartbeat cycle — such as whooshing or swishing — made by turbulent blood in or near the heart. SJ, YH Heart Murmur WEB: http://www.mayoclinic.org/diseases-conditions/heart-murmurs/basics/definition/con-20028706 10007586 cardiac murmur AE a behavior and neurological AE that is seen most frequently in schizophrenia, characterized by muscular rigidity and mental stupor, sometimes alternating with great excitement and confusion. YH, SJ WEB: http://dictionary.reference.com/browse/catatonia 10007776 catatonia AE a coronary artery disorder AE that results in narrowing of the inner surface of the carotid atery. SJ, YH WEB: http://en.wikipedia.org/wiki/Carotid_artery_stenosis 10007687 carotid artery stenosis AE orbital cellulitis AE is a sudden infection of the tissues around the eye, affecting the eyelid, eyebrow, and cheek. SJ, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001012.htm 10007918 orbital cellulitis AE Chronic cholecystitis AE the inflammation of the gallbladder persisting for a prolonged period of time or having repeated attacks. SJ, YH WEB: http://www.healthline.com/health/chronic-cholecystitis#Overview1 10008617 chronic cholecystitis AE a brain lesion AE is an area of injury or disease within the brain. SJ, YH WEB: http://www.webmd.com/brain/brain-lesions-causes-symptoms-treatments 10051290 brain lesion AE Central venous pressure increased AE is a mesaurement of the pressure of the blood within the superior and inferior vena cava and large veins of the body. Increased pressure can be the result of cardiac failure and congestion of circulation. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/central+venous+pressure 10007980 central venous pressure increased AE a brain disorder AE occurs when the brain is damaged by injury, disease, or health conditions. SJ, YH WEB: http://www.healthline.com/health/brain-disorders#Overview1 10054938 Brain disorders may affect the main areas of your brain that control how you move, think, and behave. Some tumors can constrict the blood vessels in your brain. brain disorder AE a cerebral infarction is a type of ischaemic stroke AE that is caused by a blockage in the blood vessels supplying blood to the brain. SJ WEB: http://en.wikipedia.org/wiki/Cerebral_infarction 10008118 cerebral infarction AE a nervous system AE that occurs when the cerebrospinal fluid leaks through a defect in the dura or the skull and out through the nose or ear resulting from a tear in the dura. SJ, YH, MW cerebrospinal fluid leakage AE WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/brain_tumor/center/skull-base/types/csf-leak.html 10008164 cerebrospinal fluid leak AE CTCAE: E12611 NCIt: C50487 a female reproductive system AE that refers to abnormal changes in the cells on the surface of the cervix. The changes are not cancer. But they can lead to cancer of the cervix if not treated. SJ, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001491.htm 10008263 cervical dysplasia AE a bone disorder AE that results in pain and neurological symptoms resulting from any type of condition that irritates a nerve in the cervical spine. SJ, YH WEB: http://www.spine-health.com/conditions/neck-pain/what-cervical-radiculopathy 10008303 cervical radiculopathy AE Cervical spinal stenosis AE is a nervous system AE that occurs when the spinal canal in the neck narrows. SJ, YH WEB: http://www.webmd.com/back-pain/tc/cervical-spinal-stenosis-topic-overview 10008313 cervical spinal stenosis AE a respiratory AE that results in the inability to breath because something gets stuck in the throat or because the air is not good for breathing SJ, YH WEB: http://www.merriam-webster.com/dictionary/choke 10008589 choking AE a musculoskeletal and connective tissue AE that results in tlhe disappearance of articular cartilage as the result of disintegration or dissolution of the cartilage matrix and cells. SJ, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=17184 10058112 chondrolysis AE A joint disorder AE in which the cartilage on the undersurface of the patella deteriorates and softens. SJ, YH WEB: http://www.healthline.com/health/chondromalacia-patella#Overview1 10008729 chondromalacia AE an adverse event that occurs after a therapeutic intervention YH, JX therapy adverse event a therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention YH, JX physical therapy WEB: http://en.wikipedia.org/wiki/Physical_therapy physiotherapy a seizure AE that resutls in jerking and muscle rigidity, unusual sensations affecting vision, hearing, smell, taste or touch, and memory or emothional disturbances. YH, SJ WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2 10040703 simple partial seizure AE chemosis AE is a conjunctival disorder AE that results in swelling of the conjunctiva die to exudation of abnormaly permeable capillaries. SJ, YH conjunctival edema WEB: http://en.wikipedia.org/wiki/Chemosis 10053163 chemosis AE a therapeutic intervention that is used in critically ill patients who have experienced multisystem organ failure and in whom acute renal failure has developed. YH, SJ WEB: http://www.medilexicon.com/medicaldictionary.php?t=40071 10066348 continuous venovenous hemodiafiltration a behavior and neurological AE that results in the expression of psychlogical stress in physical ways or a mental or emotional crises that begins to have a physical affect. YH, SJ functional neurological symptom disorder WEB: http://www.mayoclinic.org/diseases-conditions/conversion-disorder/basics/definition/con-20029533 10010893 conversion disorder AE a cardiac disorder AE which causes a thickening and loss of elasticity of the coronary arteries, leading to progressive insufficiency of the arteries. SJ, YH arteriosclerotic coronary artery disease coronary artery atherosclerosis WEB: http://ghr.nlm.nih.gov/glossary=coronaryarteriosclerosis 10011076 coronary arteriosclerosis AE a cardiac disorder AE which causes a partial or complete blockage of the coronary artery which can lead to heart attack. SJ, YH WEB: http://en.wikipedia.org/wiki/Coronary_occlusion 10011086 coronary occlusion AE a cardiac disorder AE which results in inflammation and the buildup of plaque which narrow the coronary arteries. SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/coronary-artery-disease/basics/definition/con-20032038 10011089 coronary artery disease AE An joint disorder AE that results in the noise produced by the rubbing together of bone or irregular cartilage surfaces. YH, SJ WEB: http://medical-dictionary.thefreedictionary.com/crepitation 10011376 crepitation AE cryptorchidism AE is a male reproductive system AE which results in the absence of one or both testes from the scrotum. YH, SJ undescended testis WEB: http://en.wikipedia.org/wiki/Cryptorchidism 10011498 cryptorchidism AE CSF glucose is proportional to blood glucose levels which correspond to 60-70% of the concentration in blood. SJ, YH hypoglycorrhachia 10011537 decreased CSF glucose AE can be caused by CNS infections, inflammatory conditions, subarachnoid hemorrhage, hypoglycemia, impaired glucose transport, increased CNS glycolytic activity and metastatic carcinoma. decreased CSF glucose AE wound culture positive AE is a a test to find and identify germs that may be growing on the skin or in a wound. If something that can cause infection grows, the culture is positive. The type of organisms may be identified with a microscope, chemical tests, or both. SJ, YH WEB: http://www.webmd.com/a-to-z-guides/skin-and-wound-cultures 10011643 wound culture positive AE skin cyst AE is a skin AE that occurs when a cluster of cells that have grouped together to form a sac which may contain air, fluids, or semi-solid material. YH, SJ cyst WEB: http://en.wikipedia.org/wiki/Cyst 10011732 skin cyst AE conductive hearing loss AE is a hearing loss AE that results from probelms with the ear canal, ear drum, or middle ear and its little bones. SJ, YH sensorineural hearing loss (SNHL) WEB: http://www.hearingloss.org/content/types-causes-and-treatment 10010282 conductive hearing loss AE transient hearing loss AE is a hearing loss AE that results from poor ventilation of the middle ear in children. SJ, YH deafness transitory WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139416/ 10011900 transient hearing loss AE a psychiatric disorder AE that results in a persistent false psychotic belief regarding the self or objects outside the self that is maintained despite indisputable evidence to the contrary. SJ, YH WEB: http://www.merriam-webster.com/dictionary/delusion 10012239 delusion AE a behavioral and neurological AE that results in long-standing need for the person to be taken care of and a fear of being abandoned or separated from important individuals. SJ, YH WEB: http://psychcentral.com/disorders/dependent-personality-disorder-symptoms/ 10012355 Individuals with Dependent Personality Disorder are often characterized by pessimism and self-doubt, and tend to belittle their abilities and assets. This leads the person to engage in dependent and submissive behaviors that are designed to elicit care-giving behaviors in others. dependent personality disorder AE Nervous system AE that results in failure to meet certain developmental milestones, such as sitting, walking, and talking, at the average age. Developmental delay may indicate a problem in development of the central nervous system. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/developmental+delay 10012559 developmental delay AE diabetic ketoacidosis AE is a cardiovascular AE that develops when your body is unable to produce enough insulin and begins to break down fat as an alternate fuel, this process produces a buildup of toxic acids in the bloodstream called ketones. SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/basics/definition/con-20026470 10012671 diabetic ketoacidosis AE Dialysis is the process of removing waste products and excess fluid from the body when the kidneys are not able to adequately filter the blood. YH, SJ WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2980 10061105 dialysis congenital diaphragmatic hernia AE is a congential disorder in which an absent or partially formed diaphragm results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. This crowding can lead to underdevelopment of the lungs, potentially resulting in life-threatening breathing difficulties that are apparent from birth. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/aspiration 10061106 congenital diaphragmatic hernia AE a paralysis AE that has an outcome of paralysis affecting symmetrical parts of the body. SJ, YH WEB: http://en.wikipedia.org/wiki/Diplegia 10013033 diplegia AE cystitis interstitial AE is a cystitis AE that has an outcome of cystitis interstitial, which is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/interstitialcystitis.html 10011796 cystitis interstitial AE A disseminated tuberculosis AE is a tuberculosis AE that has an outcome of disseminated tuberculosis, which is a contagious bacterial infection in which TB bacteria has spread from the lungs to other parts of the body through the blood or lymph system. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000624.htm 10013453 disseminated tuberculosis AE Exotosis AE is a bone pain AE that has resulted in a non-neoplastic overgrowth of bone. KM, YH WEB: http://en.wikipedia.org/wiki/Exostosis 10015688 exotosis AE An exudative retinopathy AE is an eye AE that shows an outcome of exudative retinopathy marked by masses of white or yellowish exudate in the posterior part of the fundus oculi, with deposits of cholesterol and blood debris from retinal hemorrhage, that leads to destruction of the macula and blindness. KM, YH Coats' disease, Coats' retinitis WEB: http://medical-dictionary.thefreedictionary.com/exudative+retinopathy 10015901 exudative retinopathy AE A tendon disorder AE that has an outcome of tendinous which is damage to a tendon at a cellular level. It is thought to be caused by microtears in the connective tissue in and around the tendon, leading to an increase in tendon repair cells. KM, YH WEB: http://en.wikipedia.org/wiki/Tendinosis 10016662 tendinous AE A monocyte percentage abnormal AE that results in abnormally high levels of monocytes in the blood. KM, YH WEB: http://en.wikipedia.org/wiki/Monocytosis 10027906 monocytosis AE NCIT: C35147 A male reproductive system AE that has an outcome of genital candidiasis, which is a fungal infection due to any types of Candida (types of yeasts). This is a fungal infection of the genital region. KM, YH WEB: http://en.wikipedia.org/wiki/Candidiasis WEB: http://www.cdc.gov/fungal/diseases/candidiasis/genital/ 10018143 genital candidiasis AE KM, YH WEB: http://www.webmd.com/pain-management/tc/groin-problems-and-injuries-topic-overview 10018735 A groin pain AE is a pain AE that shows a pain in the groin area. groin pain AE A blood disorder AE that has an outcome of the breakdown of red blood cells. KM, YH hemolysis WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002372.htm 10018910 haemolysis AE A hepatosplenomegaly AE is a liver inflammation AE that has an outcome of an abnormal enlargement of the liver and spleen. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/imagepages/17215.htm WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3716 10019847 hepatosplenomegaly AE A gastric disorder AE that occurs when part of your stomach pushes upward through your diaphragm. KM, YH WEB: http://www.mayoclinic.org/diseases-conditions/hiatal-hernia/basics/definition/con-20030640 10020028 hiatus hernia AE A viral infection AE that is caused by the human immunodeficiency virus. KM, YH 10020161 HIV infection AE NCIT: C3108 A hypertonic bladder AE is a digestive system AE that where the bladder-storage function that causes a sudden urge to urinate. SJ, YH irritable bladder overactive bladder WEB: http://healbladder.info/healbladder/hypertonic-bladder WEB: http://www.mayoclinic.org/diseases-conditions/overactive-bladder/basics/definition/con-20027632 10020853 hypertonic bladder AE A hypovitaminosis AE is a gustatory system AE which shows an insufficiency of one or more essential vitamins. KM, YH WEB: http://en.wikipedia.org/wiki/Hypovitaminosis 10021135 hypovitaminosis AE A gastrointestinal disorder AE that shows the inflammation of the ileum. KM, YH WEB: http://en.wikipedia.org/wiki/Ileitis 10021312 ileitis AE NCIT: C84782 A joint pain AE that occurs when there is an abnormal separation in the joint, where two or more bones meet. KM, YH dislocated joint, luxation WEB: http://en.wikipedia.org/wiki/Joint_dislocation 10023204 joint dislocation AE A syndrome AE that shows Kawasaki's disease, a vasculitis characterized by inflammation of the arteries, particularly the coronary arteries. The vasculitis may lead to aneurysm formation and possibly, heart attacks. It affects young children who usually present with persistent high fever, redness of the mucous membranes of the mouth, redness of the palms and soles, skin rashes, lymphadenitis, and joint pain and swelling. KM, YH Mucocutaneous Lymph Node Syndrome WEB: http://en.wikipedia.org/wiki/Kawasaki_disease 10023320 kawasaki disease AE NCIT: C34825 An abscess AE where a bacterial, parasitic, or fungal abscess that develops in the liver. It is usually the result of an abdominal infection, trauma, or surgery in the right upper quadrant. Signs and symptoms include abdominal pain, nausea, vomiting, and fever. KM, YH WEB: http://en.wikipedia.org/wiki/Liver_abscess 10024652 liver abscess AE NCIT: C99089 A blood disorder AE that the body's blood supply will stop moving after the heart has stopped pumping it around the inside of the deceased. KM, YH WEB: http://www.exploreforensics.co.uk/rigor-mortis-and-lividity.html 10024728 lividity AE A lymphangitis AE is an inflammation AE that has an infection of the lymph vessels (channels). KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007296.htm 10025226 lymphangitis AE An infection adverse event that results in malaria, a protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia. KM, YH WEB: http://en.wikipedia.org/wiki/Malaria 10025487 malaria AE NCIT: C34797 A metabolic disoder AE where there is increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock. KM, YH Acidosis WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000335.htm 10027417 metabolic acidosis AE NCIT: C28228 An abnormal stool AE that has an outcome of a significant amount of mucus in the stool. The mucus is accompanied by diarrhea, pain or blood may signify an intestinal condition such as infection or inflammation. Increased amounts of mucus in the stool can also occur with cancers of the colon or rectum or with bowel obstruction. KM, YH WEB: http://www.healthgrades.com/symptoms/mucus-in-stool 10028140 mucous stool AE A muscle spasm AE that has an outcome of tight or stiff muscles and an inability to control those muscles. KM, YH, MW, MW spasticity AE WEB: http://www.webmd.com/pain-management/pain-management-spasticity 10028335 10041416 muscle spasticity AE CTCAE: E12820 NCIt: C79750 A respiratory distress AE that has an outcome of a newborn dyspnea (i.e., impaired breathing) with cyanosis, most frequently occurring in premature infants, children of diabetic mothers and infants delivered by cesarean section, and sometimes with no predisposing cause. KM, YH Newborn Respiratory Distress Syndrome WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001563.htm 10001052 neonatal respiratory distress AE NCIT: C27560 A neutrophil count increased AE that has an outcome of an abnormally high level of neutrophils in the blood. KM, YH WEB: http://en.wikipedia.org/wiki/Neutrophilia 10029379 neutrophilia AE NCIT: C35164 A male reproductive system AE that results in an inflammation of one or both testes due to viral or bacterial infections. Signs and symptoms include enlargement or tenderness of the affected testis, inguinal lymphadenopathy, blood in the semen, and pain during urination, intercourse, or ejaculation. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001280.htm 10031064 orchitis AE NCIT: C97145 an inflammation AE that occurs in a bone. KM, YH Osteitis fibrosa WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001252.htm 10031149 osteitis AE A bone disorder AE that has an dissolution of bone, especially the removal or loss of the calcium of bone. KM, YH WEB: http://en.wikipedia.org/wiki/Osteolysis 10031248 osteolysis AE NCIT: C50681 An arrhythmia AE that has an outcome of palpitations, an abnormality of heartbeat characterized by simultaneous awareness of one’s pulse and discomfort. KM, YH WEB: http://en.wikipedia.org/wiki/Palpitations 10033557 palpitations AE CTCAE: E10163 NCIt: C37999 A skin AE that shows a solid, raised spot on the skin that is up to 0.5 centimeter wide, which is a type of skin lesion. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003233.htm 10033733 papule AE A parotid gladn enlargement AE that has an outcome of parotitis, the inflammation of one or more of the parotid glands. KM, YH WEB: http://emedicine.medscape.com/article/882461-overview WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001041.htm 10034038 parotitis AE A male reproductive system AE that has an disorder in a penis, including priapism, Peyronie's disease, balanitis, phimosis, paraphimosis, and penile cancer. KM, YH WEB: http://www.medicinenet.com/penis_disorders/article.htm 10034336 penis disorder AE An abdominal AE that shows an inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs. KM, YH WEB: http://en.wikipedia.org/wiki/Peritonitis 10034674 peritonitis AE NCIT: C26849 A medical intervention that collects plasma from the peripheral blood while returning the rest to the donor. KM, YH plasma exchange therapeutic plasma exchange WEB: http://en.wikipedia.org/wiki/Plasmapheresis 10035486 plasmapheresis AE NCIT: C15304 An arthritis AE that has an outcome of polyarthritis, which includes any type of arthritis that involves 5 or more joints simultaneously. KM, YH WEB: http://en.wikipedia.org/wiki/Polyarthritis 10036030 polyarthritis AE A male reproductive system AE that affects prostatic gland in the male reproductive system. KM, YH WEB: http://www.britannica.com/EBchecked/topic/479519/prostatic-disorder 10036956 prostatic disorder AE A tumor AE that shows a benign disorder of lymphoid cells or histiocytes that produces clinical features of a malignant lymphoma. KM, YH WEB: http://medical-dictionary.thefreedictionary.com/pseudolymphoma 10037108 pseudo lymphoma AE A skin AE that shows a pyogenic skin disease. These include superficial bacterial infections such as impetigo, impetigo contagiosa, ecthyma, folliculitis, Bockhart's impetigo, furuncle, carbuncle, tropical ulcer, etc. KM, YH WEB: http://en.wikipedia.org/wiki/Pyoderma 10037632 pyoderma AE A urine abnormality AE that shows the presence of white blood cells or pus in the urine, usually a sign of urinary tract infection. KM, YH WEB: http://en.wikipedia.org/wiki/Pyuria WEB: http://medical-dictionary.thefreedictionary.com/pyuria 10037686 pyuria AE a blood sodium abnormal AE that is characterized by an abnormally high level of sodium in the blood YH, MW hypernaetremia WEB: http://emedicine.medscape.com/article/241094-overview 10020679 10020680 hypernatremia AE CTCAE: E12293 HPO: HP_0003228 NCIt: C37970 SIDER: C0595878 A rash AE that shows a rash like measles. The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places. KM, YH measles-like maculopapular rash AE WEB: http://en.wikipedia.org/wiki/Morbilliform WEB: http://www.wisegeek.com/what-is-a-morbilliform-rash.htm 10037870 morbilliform rash AE A rash AE that shows a raised, blistery rash. KM, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=11955 10037898 vesicular rash AE A red blood cell count increased AE that has an increased count of reticulocytes in the blood. Reticulocytes are slightly immature red blood cells. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003637.htm 10038792 reticulocyte count increased AE a behavior and neurological AE that results in impaired or inhibited ego functioning in which the ability to process reality-based information is diminished and disordered. SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/acute+psychosis 10001022 acute psychosis AE An eye AE that shows an abnormal blood vessel development in the retina of the eye and it occurs in infants that are born too early. KM, YH Terry syndrome retrolental fibroplasia retrolental fibroplasia (RLF) WEB: http://en.wikipedia.org/wiki/Retinopathy_of_prematurity WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001618.htm 10038933 retinopathy of prematurity AE A skin AE that results in a scar, a mark left on the skin. KM, YH WEB: http://en.wikipedia.org/wiki/Scar 10039580 scar AE NCIT: C34483 A skin AE that has an outcome of a localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. KM, YH WEB: http://en.wikipedia.org/wiki/Scleroderma 10039710 Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys. scleroderma AE NCIT: C26746 A male reproductive system AE that has an outcome of an abnormal enlargement of the scrotum, the sac surrounding the testicles. KM, YH scrotal edema scrotal swelling WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003161.htm 10039755 scrotal oedema AE A skin AE that results in the degeneration and thinning of the epidermis and dermis. KM, YH, MW atrophy of the skin WEB: http://www.wisegeek.com/what-is-skin-atrophy.htm 10040799 skin atrophy AE CTCAE:E13714 NCIT: C35163 NCIt:C35163 A skin discoloration AE that shows the lightening of the skin, or loss of pigment. KM, YH Depigmentation WEB: http://en.wikipedia.org/wiki/Depigmentation 皮肤脱色 10040825 skin depigmentation AE A skin discoloration AE that shows abnormal lightening of skin due to decreased melanin production or deposition. KM, YH, MW Hypopigmentation, Pigment Dilution WEB: http://en.wikipedia.org/wiki/Hypopigmentation 10040868 Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation. skin hypopigmentation AE CTCAE:E13721 NCIt:C78610 http://en.wikipedia.org/wiki/Hypopigmentation An immune system disorder AE that has an disorder in spleen, the largest organ in the lymphatic system. KM, YH splenic diseases WEB: http://en.wikipedia.org/wiki/Splenic_disease WEB: http://www.livescience.com/44725-spleen.html 10041633 spleen disorder AE CTCAE: E10056 NCIt: C35823 a muscle AE that shows the absence or loss of control of voluntary muscle movements. SJ, YH URL: http://medical-dictionary.thefreedictionary.com/akinesia 10001541 akinesia AE a seizure AE that shows a brief episode of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. JX, YH epilepsy WEB: http://en.wikipedia.org/wiki/Epileptic_seizure 癫痫 epileptic seizure AE a cranial neuropathy AE which shows an damage or abnormality to the nerves in the eyes. RR, YH WEB: http://www.allaboutvision.com/conditions/optic-neuritis.htm 10061323 optic neuropathy AE an optic neuropathy AE characterized by optic disc swelling, peripapillary and macular hard exudates, and vitreous cells. RR, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/6466175 10060701 neuroretinitis AE an optic neuropathy AE characterized by vision loss, optic disc swelling, flame hemorrhages, and cotton-wool exudates. It occurs when blood flow is interrupted to the front (anterior) part of the optic nerve (also called optic nerve head). RR, YH AION WEB: http://emedicine.medscape.com/article/1216891-overview WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/ 10068250 anterior ischemic optic neuropathy AE a type of anterior ischemic optic neuropathy AE that presents primarily with vision loss, especially upon wakening, and sectorial disc edema. RR, YH WEB: http://emedicine.medscape.com/article/1216891-clinical#a0217 10068249 non-arteritic anterior ischemic optic neuropathy AE a peripheral neuropathy AE that shows a combination of axonal and demyelinating neuropathy. RR, YH WEB: http://www.aafp.org/afp/2010/0401/p887.html mixed neuropathy AE a peripheral sensory neuropathy AE that shows neuropathy in many sensory nerves at one time RR, YH WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html sensory peripheral polyneuropathy AE a peripheral neuropathy AE that results from the loss of the myelin sheath on peripheral nerves roughly evenly distributed on both sides of the body RR, YH peripheral demyelinating polyneuropathy AE a neuropathy AE that shows nerve damage and occurs in a patient with diabetes RR, YH WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/basics/definition/con-20033336 10012680 diabetic neuropathy AE a nervous system AE that is an umbrella term referring to conditions relating to the nervous system, including loss of sensation and paralysis RR, YH WEB: http://en.wikipedia.org/wiki/Functional_neurological_deficit neurological deficit AE An abscess AE that is caused by an Staphylococcus aureus infection. KM, YH abscess http://medical-dictionary.thefreedictionary.com/staphylococcal+abscess 10041917 staphylococcal abscess AE An eye AE that results in an intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes. KM, YH cross-eyed heterotropia wall-eyed WEB: http://en.wikipedia.org/wiki/Strabismus 10042159 strabismus AE A vein discoloration AE that has an outcome of local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes. KM, YH, MW http://en.wikipedia.org/wiki/Telangiectasia 10043189 telangiectasia AE CTCAE:E13740 NCIT: C28194 NCIt:C28194 A muscle spasm AE that results in the lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication. KM, YH, MW WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=40739 10044684 Trismus is a symptom of tetanus. trismus AE CTCAE:E12541 NCIt: C78651 A bacterial infection AE with an outcome of thypoid fever, a bacterial infectious disorder caused by the Salmonella typhi bacteria. KM, YH tyhpoid WEB: http://www.webmd.com/a-to-z-guides/typhoid-fever 10045275 Typhoid fever is often contracted by consumption of food or drink contaminated with Salmonella typhi. typhoid fever AE NCIT: C35089 a urinary system AE that results in the inflammation (swelling and irritation) of the urethra. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000439.htm 10046480 urethritis AE a skin discoloration AE which shows a chronic skin disease characterized by portions of the skin losing their pigment. KM, YH WEB: http://en.wikipedia.org/wiki/Vitiligo 白癫风；白驳风；白斑 10047642 vitiligo AE NCIT: C26915 an injury AE that displays a type of injury to flesh or skin caused by heat, electricity, chemicals, friction, or radiation. YH WEB: http://en.wikipedia.org/wiki/Burn 10006634 burn AE CTCAE: E11669 NCIt: C34441 a hematopoietic system AE which has a decreased erythrocyte sedimentation rate (ESR). EST is the rate at which red blood cells sediment in a period of one hour. KM, YH ESR erythrocyte sedimentation rate red blood cell sedimentation rate decreased AE Westergren ESR decreased AE http://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate 10049188 sedimentation rate decreased AE a skin AE that has decreased skin turgor which is the skin's ability to change shape and return to normal (elasticity). KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003281.htm 10049428 skin turgor decreased AE A tumor AE that shows a tumor occuring in the gastrointestinal tract. KM, YH WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor 10051066 gastrointestinal stromal tumour AE A bacterial infection AE that has the presence of pus in a bacterial infection. KM, YH WEB: http://dermatology.about.com/library/bldeffluctuance.htm 10051723 fluctuance AE A bacterial infection AE which is caused by Acinetobacter. KM, YH WEB: http://www.cdc.gov/HAI/organisms/acinetobacter.html 10051894 Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. Acinetobacter infections rarely occur outside of healthcare settings. acinetobacter infection AE an injury AE that breaks the skin or other body tissues. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/woundsandinjuries.html 10052428 wound AE a tuberculosis AE which is an invasion of the peritoneum by Mycobacterium tuberculosis. KM, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21215540 10053583 peritoneal tuberculosis AE a tumor AE that shows a benigh tumor of vascular origin usually seen in early childhood. YH WEB: http://radiopaedia.org/articles/haemangioma haemangioma AE a vascular disorder AE that has an outcome of the blockage of a blood vessel, usually with a clot. KM, YH WEB: http://en.wikipedia.org/wiki/Vascular_occlusion 10053648 vascular occlusion AE a tuberculosis AE that shows an tuberculosis of the joints. KM, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577591/ 10056367 joint tuberculosis AE an arrhythmia AE that shows abnormal heart rhythms that originate in the bottom chambers of the heart called the ventricles. LW, YH WEB: http://my.clevelandclinic.org/services/heart/departments-centers/ventricular-arrhythmia-center 室性心律失常 10047281 ventricular arrhythmia AE CTCAE: E10230 NCIt: C26924 A bacterial infection AE that is caused by Salmonella. KM, YH WEB: http://en.wikipedia.org/wiki/Salmonella 10058878 Salmonella AE a blood potassium abnormal AE that has a lab test outcome of abnormally lower than normal amount of potassium in the blood YH, MW hypokalemia AE hypopotassaemia AE hypopotassemia AE potassium depletion AE WEB: http://en.wikipedia.org/wiki/Hypokalemia WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia WEB: http://www.emedicinehealth.com/low_potassium/article_em.htm 血钾过少 10021015 10021018 hypokalaemia AE CTCAE: E12327 NCIt: C37974 a necrosis AE, tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (adipokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. KM, YH WEB: http://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha 10059981 alpha tumour necrosis factor AE a tumor AE that that is a benign or malignant neoplasm involving the oral cavity and/or the lips. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/oralcancer.html 10061325 oral neoplasm AE NCIT: C8989 a cardiac disorder AE that can present clinically as acute pericarditis, pericardial effusion, cardiac tamponade, and constrictive pericarditis. KM, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878263/ 10061338 pericardial disease AE a tumor AE that shows a benign or malignant neoplasm that affects the peritoneal cavity. KM, YH WEB: http://www.webmd.com/cancer/peritoneal-cancer-prognosis-symptoms-treatments 10061344 Representative examples of benign neoplasms include adenomatoid tumor and disseminated peritoneal leiomyomatosis. Representative examples of malignant neoplasms include primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma. peritoneal neoplasm AE NCIT: C3322 an inflammation AE that shows the formation or presence of pus. KM, YH MedDRA: 10061926 WEB: http://medical-dictionary.thefreedictionary.com/purulence purulence AE a bacterial infection AE with bacteria of the genus Mycobacterium. KM, YH Mycobacterium Infection WEB: http://www.nlm.nih.gov/medlineplus/mycobacterialinfections.html 10062207 mycobacterial infection AE NCIT: C26831 a tumor AE that shows the most common benign spinal neoplasm, often located in the thoracic and lumbar spine, with a peak incidence of occurrence in the fourth to sixth decades. KM, YH WEB: http://radiopaedia.org/articles/vertebral-haemangioma 10065275 spinal haemangioma AE a syndrome AE that reuslts in an autosomal recessive combined immunodeficiency syndrome caused by mutations in the RAG-1 and RAG-2 genes. It is characterized by the presence of alopecia, erythroderma, desquamation, lymphadenopathy, and chronic diarrhea. YH: This is also a genetic AE. We will later find a way to link to there. KM, YH WEB: http://en.wikipedia.org/wiki/Omenn_syndrome 10069097 Omenn syndrome AE NCIT: C61240 a immune system AE that results in a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. KM, YH WEB: http://en.wikipedia.org/wiki/Immunodeficiency immunodeficiency AE a hepatitis AE that resutls in a hepatitis C viral infection. KM, YH HCV WEB: http://en.wikipedia.org/wiki/Hepatitis_C_virus hepatitis C AE NCIT: C14312 a blood phosphorus abnormal AE that shows an abnormal blood phosphate level EB 10054823 blood phosphate abnormal AE a hematology investigation result abnormal AE that results in an abnormal level of albumin in the blood EB 10005800 blood albumin abnormal AE an electrolyte blood lab test abnormal AE that results in an abnormal level of sodium in the blood YH, MW blood carbon dioxide abnormal AE' a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally high DJ, SS, YH, MW CO2 retention AE hypercapnea AE hypercarbia AE WEB: https://en.wikipedia.org/wiki/Hypercapnia 10020591 hypercapnia AE UMLS CUI: C0020440 A physical quality that has an decreased level of glucose in the blood EB, YH, MW 10005555 blood glucose decreased UMLS CUI: C0595883 A physical quality that has an increased level of glucose in the blood EB, YH, MW 10005557 blood glucose increased UMLS CUI: C0595877 a rash AE that shows follicular eruptions characterized by papules and pustules resembling acne. YH, MW acneiform eruption AE rash acneiform AE WEB: http://en.wikipedia.org/wiki/Acne_vulgaris WEB: http://en.wikipedia.org/wiki/Acneiform_eruption 10037847 The term "acneiform", literally, refers to an appearance similar to acne. Acne vulgaris (or simply acne) is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring. acneiform rash AE CTCAE: E13694 NCIt: C35277 A rash AE that is characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back. YH WEB: http://www.medaphile.com/medical-dictionary/papulopustular-rash 10069138 Unlike acne, papulopustular rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions. papulopustular rash AE CTCAE: E11491 NCIt: C80119 an neuropathy AE that occurs when any of the twelve cranial nerves (nerves that exit from the brain directly) are damaged. MW, YH WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy 10061096 cranial neuropathy AE a cranial neuropathy AE which shows an damage or abnormality to the nerve that carries signals from the inner ear to the brain and is responsible for hearing. MW, YH WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy auditory neuropathy AE a cognitive disorder AE that shows conspicuous changes in cognitive functions. MW, YH 10009845 cognitive disturbance AE CTCAE: E12617 NCIt: C27101 an neuropathy AE that is restricted to one nerve or group of nerves, or one area of the body MW, YH WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy focal neuropathy AE a vascular disorder AE that form in a blood vessel a clot (thrombus) that breaks loose and is carried by the blood stream to plug another vessel. MW, YH thromboembolic event AE WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=25032 10043565 thromboembolism AE CTCAE: E13825 an injury AE that occurs in the cardiovascular system YH 10007654 cardiovascular injury AE UMLS CUI: C0560570 a cardiovascular injury AE that occurs in a heart. YH 10061200 heart injury AE UMLS CUI: C0018805 a heart injury AE that shows a laceration or tearing of the myoardium, which is the muscular tissue of the heart. YH WEB: https://en.wikipedia.org/wiki/Myocardial_rupture 10028604 myocardial rupture AE UMLS CUI: C0018813 a cardiomyopathy AE that is characterized by a weekened heart caused by the effects of high blood pressure. YH WEB: http://www.freemd.com/hypertensive-cardiomyopathy/overview.htm 10058222 hypertensive cardiomyopathy AE UMLS CUI: C1144799 A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy causes an obstruction of the outflow of blood from the left ventricle of the heart YH ASH HOCM IHSS asymmetric septal hypertrophy idiopathic hypertrophic subaortic stenosis WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive 10020204 hypertrophic obstructive cardiomyopathy AE UMLS CUI: C0007194 A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy does not cause an obstruction of the outflow of blood from the left ventricle of the heart YH Yamaguchi Hypertrophy Yamaguchi Syndrome apical hypertrophic cardiomyopathy idiopathic hypertrophic subaortic stenosis non-obstructive cardiomyopathy WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive hypertrophic non-obstructive cardiomyopathy AE a cardiovascular investigation result abnormal AE that results in an abnormal result on a test used to evaluate heart function YH WEB: http://www.drsinatra.com/heart-function-tests-to-assess-heart-disease-risk/ WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures 10058479 cardiac function test abnormal AE UMLS CUI: C0438177 a cardiac disorder AE that results in multiple cardiac defects. YH WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures 10058479 multiple cardiac defects AE UMLS CUI: C0438177 an injury and procedural complication AE that results in a blockage of a device. YH 10064685 device occlusion AE UMLS CUI: C1608397 a procedural complication AE that occurs after the usage of a medical device. YH device AE device adverse event medical device adverse event a skin ulceration AE that has a combined area of ulcers <1 cm and nonblanchable erythema of intact skin with associated warmth or edema MW, YH WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx Grade 1 skin ulceration AE CTCAE: E13731 0 1 a skin ulceration AE that has a combined area of ulcers 1 - 2 cm and partial thickness skin loss involving skin or subcutaneous fat MW, YH WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx Grade 2 skin ulceration AE CTCAE: E13732 a skin ulceration AE that has a combined area of ulcers >2 cm and full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia MW, YH WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx Grade 3 skin ulceration AE CTCAE: E13733 a skin ulceration AE that has any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss MW, YH WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx Grade 4 skin ulceration AE CTCAE: E13734 A dysesthesia AE that shows an uncomfortable persistent sensation in the area of the laryngopharynx. MW, YH 10062667 Laryngopharyngeal dysesthesia AE CTCAE: E13433 NCIt: C78414 a hospitalization AE that leads to an intial hospitalization. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm initial hospitalization AE a hospitalization AE that leads to a prolonged hospitalization. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm prolonged hospitalization AE an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation. YH, JX URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction local AE an adverse event that shows a result of injury or procedural complication. JX, YH injury and procedural complication AE 3/11/2019: This term became obsolete since the "or" structure is confusing, and injury AE and procedure complication AE are two different categories. obsolete: injury or procedural complication AE a nervous system AE that occurs in the central nervous system JX, YH central nervous system AE a nervous system AE that occurs in the area of meninges JX, YH WEB: https://en.wikipedia.org/wiki/Meninges meninges AE an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). meninges inflammation AE MP: MP_0001847 a mental disorder that has false personal beliefs held contrary to reality, despite contradictory evidence and common sense. MW, YH 10012260 delusions AE CTCAE: E12904 NCIt: C26741 an inflammation AE that has an inflammation involving the larynx. MW, YH 10065735 laryngeal inflammation AE CTCAE: E13411 NCIt: C26811 a male reproductive system AE that has involvement of the testis. MW, YH 10043306 testicular disorder AE CTCAE: E13215 NCIt: C26890 an urinary system AE that has urination at short intervals. MW, YH 10046539 urinary frequency AE CTCAE: E13039 NCIt: C26906 a reproduction system inflammation AE that has inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge. MW, YH 10046916 vaginal inflammation AE CTCAE: E13270 NCIt: C26911 a cranial neuropathy AE that has involvement of the trigeminal nerve (fifth cranial nerve). MW, YH 10060890 trigeminal nerve disorder AE CTCAE: E12841 NCIt: C26952 cranial neuropathy AE that has involvement of the accessory nerve (eleventh cranial nerve). MW, YH 10060929 accessory nerve disorder AE CTCAE: E12573 NCIt: C26953 a cranial neuropathy AE that has involvement of the hypoglossal nerve (twelfth cranial nerve). MW, YH 10061212 hypoglossal nerve disorder AE CTCAE: E12692 NCIt: C26954 a hemorrhage AE that has bleeding from the pharynx. MW, YH 10055315 pharyngeal hemorrhage AE CTCAE: E13460 NCIt: C26986 a distal neuropathy AE that has regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand. MW, YH 10065417 brachial plexopathy AE CTCAE: E12601 NCIt: C27194 a cranial neuropathy AE that has involvement of the acoustic nerve (eighth cranial nerve) MW, YH 10000521 acoustic nerve disorder NOS AE CTCAE: E12577 NCIt: C27207 a cranial neuropathy AE that has involvement of the olfactory nerve (first cranial nerve). MW, YH 10056388 olfactory nerve disorder AE CTCAE: E12755 NCIt: C27210 a cranial neuropathy AE that has involvement of the glossopharyngeal nerve (ninth cranial nerve). MW, YH 10061185 glossopharyngeal nerve disorder AE CTCAE: E12672 NCIt: C27211 a cranial neuropathy AE that has involvement of the vagus nerve (tenth cranial nerve). MW, YH 10061403 vagus nerve disorder AE CTCAE: E12845 NCIt: C27591 a cranial neuropathy AE that has involvement of the abducens nerve (sixth cranial nerve). MW, YH 10053662 abducens nerve disorder AE CTCAE: E12569 NCIt: C27593 a cranial neuropathy AE that has involvement of the facial nerve (seventh cranial nerve). MW, YH 10061457 facial nerve disorder AE CTCAE: E12668 NCIt: C27594 a cranial neuropathy AE that has involvement of the oculomotor nerve (third cranial nerve). MW, YH 10053661 oculomotor nerve disorder AE CTCAE: E12751 NCIt: C27598 a sensory neuropathy AE that has distortion of sensory perception, resulting in an abnormal and unpleasant sensation. MW, YH 10062872 dysesthesia AE CTCAE: E12639 NCIt: C28246 a pain AE that has painful or difficult coitus. MW, YH 10013941 dyspareunia AE CTCAE: E13081 NCIt: C2997 a bone disorder AE that has non-neoplastic overgrowth of bone. MW, YH 10015688 exostosis AE CTCAE: E12404 NCIt: C3029 an endocrine system AE that has excessive development of the breasts in males. MW, YH 10018801 gynecomastia AE CTCAE: E13115 NCIt: C3073 a brain edema AE that has an abnormal increase of cerebrospinal fluid in the ventricles of the brain. MW, YH 10020508 hydrocephalus AE CTCAE: E12682 NCIt: C3111 an edema AE that has excessive fluid collection in tissues that causes swelling. MW, YH 10025233 lymphedema AE CTCAE: E13802 NCIt: C3207 a menstrual disorder AE that has the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age. MW, YH 10027308 menopause AE CTCAE: E13750 NCIt: C3231 a physical examination result abnormal AE that is having a high amount of body fat. MW, YH 10029883 obesity AE CTCAE: E12361 NCIt: C3283 a lung inflammation AE that has progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. MW, YH 10001409 adult respiratory distress syndrome AE CTCAE: E13299 NCIt: C3353 a cardiovascular AE that has obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache. MW, YH Superior vena cava syndrome AE CTCAE: E13819 NCIt: C3396 a menstrual disorder AE that has abnormally painful abdominal cramps during menses. MW, YH 10013934 dysmenorrhea AE CTCAE: E13077 NCIt: C34559 a behavior and neurological AE that has an exaggerated feeling of well-being which is disproportionate to events and stimuli. MW, YH 10015533 euphoria AE CTCAE: E12915 NCIt: C34598 a pain AE that has marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. MW, YH 10016750 flank pain flank pain AE CTCAE: E12414 NCIt: C34615 a metabolic disorder AE that has an inability to properly metabolize glucose. MW, YH 10052426 glucose intolerance AE CTCAE: E12264 NCIt: C34646 a urine abnormality AE that has laboratory test results that indicate the presence of free hemoglobin in the urine. MW, YH haemoglobinuria AE 10018906 10019489 hemoglobinuria AE CTCAE: E13006 NCIt: C34677 a sweating AE that has reduced sweating. MW, YH 10021013 hypohidrosis AE CTCAE: E13652 NCIt: C34718 a bone disorder AE that has an abnormal increase in the curvature of the thoracic portion of the spine. MW, YH 10023509 kyphosis AE CTCAE: E12447 NCIt: C34754 a bone disorder AE that has an abnormal increase in the curvature of the lumbar portion of the spine. MW, YH 10024842 lordosis AE CTCAE: E12451 NCIt: C34787 a male reproductive system AE that has a decrease in the number of spermatozoa in the semen. MW, YH 10030300 oligospermia AE CTCAE: E13141 NCIt: C34860 a necrosis AE that has necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. MW, YH 10066480 avascular necrosis AE CTCAE: E12382 NCIt: C34880 an inflammation AE that has inflammation of the skin characterized by the presence of bullae which are filled with fluid. MW, YH 10006556 bullous dermatitis AE CTCAE: E13617 NCIt: C35149 a speech disorder AE that has impairment of verbal communication skills, often resulting from brain damage. MW, YH 10013951 dysphasia AE CTCAE: E12646 NCIt: C35546 a female reproductive system AE that has a narrowing of the vaginal canal. MW, YH 10053496 vaginal stricture AE CTCAE: E13290 NCIt: C36064 a metabolism, endocrine, and exocrine system AE that has abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues. MW, YH 10001680 alkalosis AE CTCAE: E12247 NCIt: C37909 a gastrointestinal disorder AE that has repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm. MW, YH 10020039 Hiccups AE CTCAE: E13380 NCIt: C37966 an urine abnormality AE that has laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin. MW, YH 10037032 proteinuria AE CTCAE: E13008 NCIt: C38012 an inflammation AE that has generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area. MW, YH 10015277 erythroderma AE CTCAE: E13633 NCIt: C39646 a syndrome AE that has dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination. MW, YH 10063636 pyramidal tract syndrome AE CTCAE: E12780 NCIt: C43245 a brain edema AE that has swelling due to an excessive accumulation of fluid in the brain. MW, YH 10014217 edema cerebral AE CTCAE: E12650 NCIt: C4909 a tumor AE that has development of a malignancy most probably as a result of treatment for a previously existing malignancy. MW, YH 10049737 treatment related secondary malignancy AE CTCAE: E12561 NCIt: C4969 a hemorrhage AE that has bleeding from the cranium. MW, YH 10022763 intracranial hemorrhage AE CTCAE: E12696 NCIt: C50438 a death AE that has death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. MW, YH 10016479 fetal death AE CTCAE: E12855 NCIt: C50620 a ischemia AEE that has a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. MW, YH 10044391 transient ischemic attacks AE CTCAE: E12834 NCIt: C50781 afemale reproductive system AE that has vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. MW, YH 10046901 vaginal discharge AE CTCAE: E13251 NCIt: C50795 a sensory capability AE that has a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve. MW, YH 10047166 vasovagal reaction AE CTCAE: E12851 NCIt: C50798 apregnancy AE that has delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation. MW, YH 早产 10036595 premature delivery AE CTCAE: E12867 NCIt: C50917 a psychiatric disorder AE that has excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood. MW, YH 10026749 mania AE CTCAE: E12936 NCIt: C61374 a hair growth abnormal AE that has the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen) MW, YH 10020112 hirsutism AE CTCAE: E13642 NCIt: C61444 a necrosis AE that has a necrotic process occurring in the bone of the mandible. MW, YH 10064658 osteonecrosis of jaw AE CTCAE: E12502 NCIt: C63924 a necrosis AE that has a necrotic process occurring in the soft tissues of the abdominal wall. MW, YH 10065775 abdominal soft tissue necrosis AE CTCAE: E12369 NCIt: C78165 a metabolic disorder AE that has an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. MW, YH 10001598 alcohol intolerance AE CTCAE: E12242 NCIt: C78167 a psychiatric disorder AE that has an inability to achieve orgasm. MW, YH 10002652 anorgasmia AE CTCAE: E12880 NCIt: C78177 an urinary system AE that has a rupture in the bladder wall. MW, YH 10063575 bladder perforation AE CTCAE: E12979 NCIt: C78208 an urinary system AE that has a sudden and involuntary contraction of the bladder wall. MW, YH 10048994 bladder spasm AE CTCAE: E12984 NCIt: C78210 a hemorrhage AE that is bleeding from the bronchial wall and/or lung parenchyma. MW, YH 10065746 bronchopulmonary hemorrhage AE CTCAE: E13346 NCIt: C78224 a respiratory system AE that has blockage of a bronchus passage, most often by bronchial secretions and exudates. MW, YH 10006440 bronchial obstruction AE CTCAE: E13328 NCIt: C78225 a respiratory system AE that has a narrowing of the bronchial tube. MW, YH 10063524 bronchial stricture AE CTCAE: E13334 NCIt: C78226 a necrosis AE that has a necrotic process occurring in the brain and/or spinal cord. MW, YH 10065784 central nervous system necrosis AE CTCAE: E12605 NCIt: C78236 a pain AE that has marked discomfort sensation in the chest wall region. MW, YH 10008496 chest wall pain AE CTCAE: E12400 NCIt: C78238 a cystitis AE that has inflammation of the bladder which is not caused by an infection of the urinary tract. MW, YH 10063057 cystitis noninfective AE CTCAE: E12994 NCIt: C78250 a psychiatric disorder AE that has sexual dysfunction characterized by a delay in climax. MW, YH 10057066 delayed orgasm AE CTCAE: E12895 NCIt: C78252 a male reproductive system AE that has problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation. MW, YH 10014326 ejaculation disorder AE CTCAE: E13085 NCIt: C78264 a muscular weakness AE that has a reduction in the strength of the facial muscles. MW, YH 10051272 facial muscle weakness AE CTCAE: E12664 NCIt: C78290 a female reproductive system AE that has blockage of the normal flow of the contents in the fallopian tube. MW, YH 10065789 fallopian tube obstruction AE CTCAE: E13092 NCIt: C78293 a female reproductive system AE that has a narrowing of the fallopian tube lumen. MW, YH 10065791 fallopian tube stenosis AE CTCAE: E13096 NCIt: C78295 a connective tissue disorder AE that has shrinking of adipose tissue. MW, YH 10016241 fat atrophy AE CTCAE: E13638 NCIt: C78297 a fistula AE that has an abnormal communication between a female reproductive system organ and another organ or anatomic site. MW, YH 10061149 female genital tract fistula AE CTCAE: E13102 NCIt: C78298 an endocrine system AE that has the development of secondary female sex characteristics in males due to extrinsic factors. MW, YH 10054382 feminization acquired AE CTCAE: E13108 NCIt: C78299 a connective tissue disorder AE that has fibrotic degeneration of the deep connective tissues. MW, YH 10065799 fibrosis deep connective tissue AE CTCAE: E12408 NCIt: C78301 a muscular weakness AE that has a reduction in the strength of muscles in multiple anatomic sites. MW, YH 10062572 generalized muscle weakness AE CTCAE: E12418 NCIt: C78323 a musculoskeletal and connective tissue AE that has stature that is smaller than normal as expected for age. MW, YH 10018761 growth suppression AE CTCAE: E12422 NCIt: C78328 a necrosis AE that has a necrotic process occurring in the soft tissues of the head. MW, YH 10065779 head soft tissue necrosis AE CTCAE: E12426 NCIt: C78331 a female reproductive system AE that has the presence of blood in a fallopian tube. MW, YH 10060602 hematosalpinx AE CTCAE: E13119 NCIt: C78332 a sleep disorder AE that has characterized by excessive sleepiness during the daytime. MW, YH 10020765 hypersomnia AE CTCAE: E12688 NCIt: C78346 a homeostasis AE that has accumulation of iron in the tissues. MW, YH 10065973 iron overload AE CTCAE: E12350 NCIt: C78393 an ischemia AE that has a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage. MW, YH 10023030 ischemia cerebrovascular AE CTCAE: E12702 NCIt: C78394 a cranial neuropathy AE that has involvement of the trochlear nerve (fourth cranial nerve). MW, YH 10065836 IVth nerve disorder AE CTCAE: E12705 NCIt: C78395 a joint disorder AE that has a decrease in flexibility of a cervical spine joint. MW, YH 10065796 joint range of motion decreased cervical spine AE CTCAE: E12439 NCIt: C78404 a joint disorder AE that has a decrease in flexibility of a lumbar spine joint. MW, YH 10065800 joint range of motion decreased lumbar spine AE CTCAE: E12443 NCIt: C78405 a fistula AE that has an abnormal communication between the larynx and another organ or anatomic site. MW, YH 10065786 laryngeal fistula AE CTCAE: E13399 NCIt: C78410 a hemorrhage AE that has bleeding from the larynx. MW, YH 10065759 laryngeal hemorrhage AE CTCAE: E13405 NCIt: C78411 an inflammation AE that has an inflammation involving the mucous membrane of the larynx. MW, YH 10065880 laryngeal mucositis AE CTCAE: E13415 NCIt: C78412 a respiratory system AE that has blockage of the laryngeal airway. MW, YH 10059639 laryngeal obstruction AE CTCAE: E13421 NCIt: C78413 a libido disorder AE that has a decrease in sexual desire. MW, YH 10024419 libido decreased AE CTCAE: E12929 NCIt: C78432 a libido disorder AE that has an increase in sexual desire. MW, YH 10024421 libido increased AE CTCAE: E12932 NCIt: C78433 a skin AE that has hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. MW, YH 10062315 lipohypertrophy AE CTCAE: E13657 NCIt: C78436 an immune system AE that has the loss of lymph fluid into the surrounding tissue or body cavity. MW, YH 10065773 lymph leakage AE CTCAE: E13797 NCIt: C78439 an immune system AE that has a cystic lesion containing lymph. MW, YH 10048642 lymphocele AE CTCAE: E13806 NCIt: C78442 a hemorrhage AE that has bleeding from the mediastinum. MW, YH 10056356 mediastinal hemorrhage AE CTCAE: E13444 NCIt: C78443 a movement disorder AE that has uncontrolled and purposeless movements. MW, YH 10028041 movements involuntary AE CTCAE: E12728 NCIt: C78453 a muscular weakness AE that has a reduction in the strength of the muscles on the left side of the body. MW, YH 10065780 muscle weakness left-sided AE CTCAE: E12455 NCIt: C78455 a muscular weakness AE that has a reduction in the strength of the lower limb muscles. MW, YH 10065776 muscle weakness lower limb AE CTCAE: E12459 NCIt: C78456 a muscular weakness AE that has a reduction in the strength of the muscles on the right side of the body. MW, YH 10065794 muscle weakness right-sided AE CTCAE: E12463 NCIt: C78457 a muscular weakness AE that has a reduction in the strength of the trunk muscles. MW, YH 10065795 muscle weakness trunk AE CTCAE: E12467 NCIt: C78458 a muscular weakness AE that has a reduction in the strength of the upper limb muscles. MW, YH 10065895 muscle weakness upper limb AE CTCAE: E12471 NCIt: C78459 a musculoskeletal and connective tissue AE that has a malformation of the musculoskeletal system. MW, YH 10065783 musculoskeletal deformity AE CTCAE: E12481 NCIt: C78488 a nail AE that has a change in the color of the nail plate. MW, YH 10028691 nail discoloration AE CTCAE: E13661 NCIt: C78492 a nail AE that has loss of all or a portion of the nail. MW, YH 10049281 nail loss AE CTCAE: E13663 NCIt: C78494 a nail AE that has vertical or horizontal ridges on the nails. MW, YH 10062283 nail ridging AE CTCAE: E13666 NCIt: C78499 a necrosis AE that has a necrotic process occurring in the soft tissues of the neck. MW, YH 10065781 neck soft tissue necrosis AE CTCAE: E12497 NCIt: C78502 a female reproductive system AE that has a malformation of the nipple. MW, YH 10065823 nipple deformity AE CTCAE: E13138 NCIt: C78503 a hemorrhage AE that has bleeding from the ovary. MW, YH 10065763 ovarian hemorrhage AE CTCAE: E13145 NCIt: C78511 a female reproductive system AE that is tearing or disruption of the ovarian tissue. MW, YH 10033279 ovarian rupture AE CTCAE: E13151 NCIt: C78513 a pain AE that has marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle. MW, YH 10033314 ovulation pain AE CTCAE: E13157 NCIt: C78514 a muscular weakness AE that has a reduction in the strength of the muscles of the pelvic floor. MW, YH 10064026 pelvic floor muscle weakness AE CTCAE: E13161 NCIt: C78524 a necrosis AE that has a necrotic process occurring in the soft tissues of the pelvis. MW, YH 10065793 pelvic soft tissue necrosis AE CTCAE: E12516 NCIt: C78525 a pain AE that has marked discomfort sensation in the penis. MW, YH 10034310 penile pain AE CTCAE: E13171 NCIt: C78527 a psychiatric disorder AE that has a conspicuous change in a person's behavior and thinking. MW, YH 10034719 personality change AE CTCAE: E12942 NCIt: C78548 a fistula AE that has an abnormal communication between the pharynx and another organ or anatomic site. MW, YH 10034825 pharyngeal fistula AE CTCAE: E13454 NCIt: C78551 an inflammation AE that has an inflammation involving the mucous membrane of the pharynx. MW, YH 10065881 pharyngeal mucositis AE CTCAE: E13466 NCIt: C78553 a necrosis AE that has a necrotic process occurring in the pharynx. MW, YH 10065706 pharyngeal necrosis AE CTCAE: E13472 NCIt: C78554 a respiratory system AE that has a narrowing of the pharyngeal airway. MW, YH 10050028 pharyngeal stenosis AE CTCAE: E13476 NCIt: C78555 a hemorrhage AE that has bleeding from the prostate gland. MW, YH 10055325 prostatic hemorrhage AE CTCAE: E13181 NCIt: C78572 a prostatic disorder AE that has compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder). MW, YH 10055026 prostatic obstruction AE CTCAE: E13187 NCIt: C78573 a pain AE that has a sensation of marked discomfort in the prostate gland. MW, YH 10036968 prostatic pain AE CTCAE: E13191 NCIt: C78574 a psychiatric disorder AE that has personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor. MW, YH 10037234 psychosis AE CTCAE: E12954 NCIt: C78576 a fistula AE that has an abnormal communication between the lung and another organ or anatomic site. MW, YH 10065873 pulmonary fistula AE CTCAE: E13533 NCIt: C78577 an inflammation AE that has inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root. MW, YH 10061928 radiculitis AE CTCAE: E12786 NCIt: C78581 a recurrent alsy AE that occurs at the laryngeal nerve. MW, YH 10038130 recurrent laryngeal nerve palsy AE CTCAE: E12792 NCIt: C78592 a renal calculus AE that has paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones. MW, YH 10038419 renal colic AE CTCAE: E13024 NCIt: C78593 a hemorrhage AE that has bleeding from the kidney. MW, YH 10038463 renal hemorrhage AE CTCAE: E13028 NCIt: C78594 a syndrome AE that has weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid. MW, YH 10038921 retinoic acid syndrome AE CTCAE: E13554 NCIt: C78597 a bone disorder AE that has a malformed, lateral curvature of the spine. MW, YH 10039722 scoliosis AE CTCAE: E12521 NCIt: C78603 a pain AE that has marked discomfort sensation in the scrotal area. MW, YH 10039757 scrotal pain AE CTCAE: E13201 NCIt: C78607 a pain AE that has marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses. MW, YH 10040747 sinus pain AE CTCAE: E12810 NCIt: C78609 an induration AE that has an area of hardness in the skin. MW, YH 10051837 skin induration AE CTCAE: E13724 NCIt: C78611 a necrosis AE that has a necrotic process occurring in the soft tissues of the lower extremity. MW, YH 10065777 soft tissue necrosis lower limb AE CTCAE: E12525 NCIt: C78620 a necrosis AE that has a necrotic process occurring in the soft tissues of the upper extremity. MW, YH 10065778 soft tissue necrosis upper limb AE CTCAE: E12530 NCIt: C78621 a hemorrhage AE that has bleeding from the spermatic cord. MW, YH 10065762 spermatic cord hemorrhage AE CTCAE: E13205 NCIt: C78623 a male reproductive system AE that has blockage of the normal flow of the contents of the spermatic cord. MW, YH 10065805 spermatic cord obstruction AE CTCAE: E13211 NCIt: C78624 a connective tissue disorder AE that has fibrotic degeneration of the superficial soft tissues. MW, YH 10065798 superficial soft tissue fibrosis AE CTCAE: E12535 NCIt: C78633 a hemorrhage AE that has bleeding from the testis. MW, YH 10055347 testicular hemorrhage AE CTCAE: E13221 NCIt: C78635 a pain AE that has a sensation of marked discomfort in the testis. MW, YH 10043345 testicular pain AE CTCAE: E13227 NCIt: C78636 a fistula AE that hasan abnormal communication between the trachea and another organ or anatomic site. MW, YH 10065787 tracheal fistula AE CTCAE: E13583 NCIt: C78641 an inflammation AE that has an inflammation involving the mucous membrane of the trachea. MW, YH 10065900 tracheal mucositis AE CTCAE: E13589 NCIt: C78644 a respiratory system AE that has a narrowing of the trachea. MW, YH 10050816 tracheal stenosis AE CTCAE: E13595 NCIt: C78646 a pain AE that has marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis. MW, YH 10045158 tumor pain AE CTCAE: E12565 NCIt: C78656 a musculoskeletal and connective tissue AE that hasa discrepancy between the lengths of the lower or upper extremities. MW, YH 10065738 unequal limb length AE CTCAE: E12545 NCIt: C78657 an urine abnormality AE that has a change in the color of the urine. MW, YH 10046628 urine discoloration AE CTCAE: E13065 NCIt: C78678 a fistula AE that has an abnormal communication between the uterus and another organ or anatomic site. MW, YH 10065811 uterine fistula AE CTCAE: E13231 NCIt: C78685 an urinary system AE that has blockage of the uterine outlet. MW, YH 10065928 uterine obstruction AE CTCAE: E13243 NCIt: C78693 a pain AE that has a sensation of marked discomfort in the uterus. MW, YH 10046809 uterine pain AE CTCAE: E13247 NCIt: C78694 a female reproductive system AE that has an uncomfortable feeling of itching and burning in the vagina. MW, YH 10046904 vaginal dryness AE CTCAE: E13254 NCIt: C78699 a female reproductive system AE that has blockage of vaginal canal. MW, YH 10065817 vaginal obstruction AE CTCAE: E13276 NCIt: C78700 a pain AE that has a sensation of marked discomfort in the vagina. MW, YH 10046937 vaginal pain AE CTCAE: E13280 NCIt: C78701 a female reproductive system AE that has a rupture in the vaginal wall. MW, YH 10065818 vaginal perforation AE CTCAE: E13284 NCIt: C78702 a female reproductive system AE that hasinvoluntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse. MW, YH 10046947 vaginismus AE CTCAE: E13295 NCIt: C78703 an ischemia AE that has a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery. MW, YH 10054692 visceral arterial ischemia AE CTCAE: E13843 NCIt: C78712 a skin AE that has an abnormal body smell resulting from the growth of bacteria on the body. MW, YH 10005901 body odor AE CTCAE: E13614 NCIt: C79542 a fistula AE that has an abnormal communication between the bronchus and another organ or anatomic site. MW, YH 10006437 bronchial fistula AE CTCAE: E13322 NCIt: C79543 a nervous system AE that has an abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. MW, YH 10015832 extrapyramidal disorder AE CTCAE: E12658 NCIt: C79593 a hair growth abnormal AE that has hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race. MW, YH 10020864 hypertrichosis AE CTCAE: E13649 NCIt: C79597 a female reproductive system AE that has disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males. MW, YH 10061261 lactation disorder AE CTCAE: E13129 NCIt: C79606 a respiratory system AE that has a narrowing of the laryngeal airway. MW, YH 10023862 laryngeal stenosis AE CTCAE: E13427 NCIt: C79608 a nervous system AE that has neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges. MW, YH 10027198 meningismus AE CTCAE: E12722 NCIt: C79694 a pain AE that has marked discomfort related to a limb or an organ that is removed from or is not physically part of the body. MW, YH 10056238 phantom pain AE CTCAE: E12774 NCIt: C79703 a pain AE that has marked discomfort sensation in the skin covering the top and the back of the head. MW, YH 10049120 scalp pain AE CTCAE: E13704 NCIt: C79716 a pregnancy AE that has an unexpected pregnancy at the time of conception. MW, YH 10045542 unintended pregnancy AE CTCAE: E12872 NCIt: C79801 a urinary tract disoder AE that has blockage of the normal flow of contents of the urinary tract. MW, YH 10061574 urinary tract obstruction AE CTCAE: E13052 NCIt: C79805 a fistula AE that has an abnormal communication between the vagina and another organ or anatomic site. MW, YH 10065813 vaginal fistula AE CTCAE: E13258 NCIt: C79847 a fistula AE that has an abnormal communication between any part of the urinary system and another organ or anatomic site. MW, YH 10065368 urinary fistula AE CTCAE: E13034 NCIt: C79850 a male reproductive system AE that has laboratory test results that indicate complete absence of spermatozoa in the semen. MW, YH 10003883 azoospermia AE CTCAE: E13067 NCIt: C80076 a renal failure AE that has gradual and usually permanent loss of kidney function resulting in renal failure. MW, YH 10064848 chronic kidney disease AE CTCAE: E12988 NCIt: C80078 a behavior and neurological AE that has a deterioration in the ability to concentrate. MW, YH 10010250 concentration impairment AE CTCAE: E12621 NCIt: C80081 a fetal disorder AE that has inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight. MW, YH 10054746 fetal growth retardation AE CTCAE: E12857 NCIt: C80083 a menstrual disorder AE that has ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive. MW, YH 10036601 premature menopause AE CTCAE: E13179 NCIt: C80099 a tumor AE that has leukemia arising as a result of the mutagenic effect of chemotherapy agents. MW, YH 10048293 leukemia secondary to oncology chemotherapy AE CTCAE: E12549 NCIt: C80691 a fistula AE that has an abnormal communication between a bronchus and the pleural cavity. MW, YH 10053481 bronchopleural fistula AE CTCAE: E13340 NCIt: C80694 a pain AE that has a sensation of marked discomfort in the urinary tract. MW, YH 10062225 urinary tract pain AE CTCAE: E13058 NCIt: C83493 a female reproductive system AE that has underdevelopment of the breast. MW, YH 10006179 breast atrophy AE CTCAE: E13069 NCIt: C83494 a medical intervention that refers to any series of pre-defined steps that should be followed to achieve a desired result. YH, SS WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm medical procedure an AE that occurs in an incision site. YH, SS incision site AE a medical intervention site that is used for incision for a surgery. YH, SS incision site a hymphedema AE that has trace thickening or faint discoloration YH, MW Grade 1 lymphedema AE CTCAE: E13803 a hymphedema AE that has marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL YH, MW Grade 2 lymphedema AE CTCAE: E13804 a superior vena cava syndrome AE that has asymptomatic; incidental finding of SVC thrombosis YH, MW Grade 1 superior vena cava syndrome AE CTCAE: E13820 a superior vena cava syndrome AEthat has symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy) YH, MW Grade 2 superior vena cava syndrome AE CTCAE: E13821 a superior vena cava syndrome AE that has severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting) YH, MW Grade 3 superior vena cava syndrome AE CTCAE: E13822 a superior vena cava syndrome AE that has life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery) YH, MW Grade 4 superior vena cava syndrome AE CTCAE: E13823 a thromboembolic event AE that has venous thrombosis (e.g., superficial thrombosis) YH, MW Grade 1 thromboembolic event AE CTCAE: E13826 a thromboembolic event AE that has venous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated YH, MW Grade 2 thromboembolic event AE CTCAE: E13827 a thromboembolic event AE that has thrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus), medical intervention indicated YH, MW Grade 3 thromboembolic event AE CTCAE: E13828 a thromboembolic event AE that has life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated YH, MW Grade 4 thromboembolic event AE CTCAE: E13829 a visceral arterial ischemia AE that has brief (<24 hrs) episode of ischemia managed medically and without permanent deficit YH, MW Grade 2 visceral arterial ischemia AE CTCAE: E13844 a visceral arterial ischemia AE that has prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated YH, MW Grade 3 visceral arterial ischemia AE CTCAE: E13845 a menopause AE that the menopause occurres at age 46 - 53 years of age YH, MW Grade 1 menopause AE CTCAE: E13751 a menopause AE that the menopause occurres at age 40 - 45 years of age YH, MW Grade 2 menopause AE CTCAE: E13752 a menopause AE that the menopause occurres before age 40 years of age YH, MW Grade 3 menopause AE CTCAE: E13753 a body odor AE that has mild odor; physician intervention not indicated; self care interventions YH, MW Grade 1 body odor AE CTCAE: E13615 a body odor AE that has pronounced odor; psychosocial impact; patient seeks medical intervention YH, MW Grade 2 body odor AE CTCAE: E13616 a bullous AE that has asymptomatic; blisters covering <10% BSA YH, MW Grade 1 bullous dermatitis AE CTCAE: E13618 a bullous AE that has blisters covering 10 - 30% BSA; painful blisters; limiting instrumental ADL YH, MW Grade 2 bullous dermatitis AE CTCAE: E13619 a bullous AE that has blisters covering >30% BSA; limiting self care ADL YH, MW Grade 3 bullous dermatitis AE CTCAE: E13620 a bullous AE that has blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated YH, MW Grade 4 bullous dermatitis AE CTCAE: E13621 an erythroderma AE that has erythema covering >90% BSA without associated symptoms; limiting instrumental ADL YH, MW Grade 2 erythroderma AE CTCAE: E13634 an erythroderma AE that has erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL YH, MW Grade 3 erythroderma AE CTCAE: E13635 an erythroderma AE that has erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated YH, MW Grade 4 erythroderma AE CTCAE: E13636 a fat atrophy AE that is covering <10% BSA and asymptomatic YH, MW Grade 1 fat atrophy AE CTCAE: E13639 a fat atrophy AE that is covering 10 - 30% BSA and associated with erythema or tenderness; limiting instrumental ADL YH, MW Grade 2 fat atrophy AE CTCAE: E13640 a fat atrophy AE that is covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL YH, MW Grade 3 fat atrophy AE CTCAE: E13641 a hirsutism AE that is In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair YH, MW Grade 1 hirsutism AE CTCAE: E13643 a hirsutism AE that In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact YH, MW Grade 2 hirsutism AE CTCAE: E13644 a hypertrichosis AE that has increased in length, thickness or density of hair. The patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal YH, MW Grade 1 hypertrichosis AE CTCAE: E13650 a hypertrichosis AE that has increased in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact YH, MW Grade 2 hypertrichosis AE CTCAE: E13651 a hypertrichosis AE that has increased in body temperature; limiting self care ADL YH, MW Grade 3 hypohidrosis AE CTCAE: E13654 a hypertrichosis AE that has heat stroke YH, MW Grade 4 hypohidrosis AE CTCAE: E13655 a lipohypertrophy AE that has asymptomatic and covering <10% BSA YH, MW Grade 1 lipohypertrophy AE CTCAE: E13658 a lipohypertrophy AE that covers 10 - 30% BSA and associated tenderness; limiting instrumental ADL YH, MW Grade 2 lipohypertrophy AE CTCAE: E13659 a lipohypertrophy AE that covers >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL YH, MW Grade 3 lipohypertrophy AE CTCAE: E13660 a nail loss AE that has asymptomatic separation of the nail bed from the nail plate or nail loss YH, MW Grade 1 nail loss AE CTCAE: E13664 a nail loss AE that has symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL YH, MW Grade 2 nail loss AE CTCAE: E13665 a rash acneiform AE that has papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness YH, MW Grade 1 rash acneiform AE CTCAE: E13695 a rash acneiform AE that has papules and/or pustules covering 10 - 30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL YH, MW Grade 2 rash acneiform AE CTCAE: E13696 a rash acneiform AE that has papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self care ADL; associated with local superinfection with oral antibiotics indicated YH, MW Grade 3 rash acneiform AE CTCAE: E13697 a rash acneiform AE that has papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences YH, MW Grade 4 rash acneiform AE CTCAE: E13698 a rash maculopapular AE that has macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness) YH, MW Grade 1 rash maculo-papular AE CTCAE: E13701 a rash maculopapular AE that has macules/papules covering 10 - 30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL YH, MW Grade 2 rash maculo-papular AE CTCAE: E13702 a rash maculopapular AE that has macules/papules covering >30% BSA with or without associated symptoms; limiting self care ADL YH, MW Grade 3 rash maculo-papular AE CTCAE: E13703 a skin induration AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) YH, MW Grade 1 skin induration AE CTCAE: E13725 a skin induration AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL YH, MW Grade 2 skin induration AE CTCAE: E13726 a skin induration AE that has severe induration, unable to slide or pinch skin; limiting joint movement or orifice (e.g., mouth, anus); limiting self care ADL YH, MW Grade 3 skin induration AE CTCAE: E13727 a skin induration AE that has generalized; associated with signs or symptoms of impaired breathing or feeding YH, MW Grade 4 skin induration AE CTCAE: E13728 a bronchial fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL YH, MW Grade 2 bronchial fistula AE CTCAE: E13324 a bronchial fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW Grade 3 bronchial fistula AE CTCAE: E13325 a bronchial fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated YH, MW Grade 4 bronchial fistula AE CTCAE: E13326 a bronchial obstruction AE that has symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators) YH, MW Grade 2 bronchial obstruction AE CTCAE: E13330 a bronchial obstruction AE that has shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) YH, MW Grade 3 bronchial obstruction AE CTCAE: E13331 a bronchial stricture AE that AE symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators) YH, MW Grade 2 bronchial stricture AE CTCAE: E13336 a bronchial stricture AE that AE shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) YH, MW Grade 3 bronchial stricture AE CTCAE: E13337 a bronchopleural fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW Grade 3 bronchopleural fistula AE CTCAE: E13343 a bronchopleural fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated YH, MW Grade 4 bronchopleural fistula AE CTCAE: E13344 a laryngeal fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL YH, MW Grade 2 laryngeal fistula AE CTCAE: E13401 a laryngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW Grade 3 laryngeal fistula AE CTCAE: E13402 a laryngeal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) YH, MW Grade 4 laryngeal fistula AE CTCAE: E13403 a laryngeal hemorrhage AE that has mild cough or trace hemoptysis; laryngoscopic findings YH, MW Grade 1 laryngeal hemorrhage AE CTCAE: E13406 a laryngeal inflammation AE that has mild sore throat; raspy voice YH, MW Grade 1 laryngeal inflammation AE CTCAE: E13412 a laryngeal inflammation AE that has moderate sore throat; analgesics indicated YH, MW Grade 2 laryngeal inflammation AE CTCAE: E13413 a laryngeal inflammation AE that has severe throat pain; endoscopic intervention indicated YH, MW Grade 3 laryngeal inflammation AE CTCAE: E13414 a laryngeal mucositis AE that has endoscopic findings only; mild discomfort with normal intake YH, MW Grade 1 laryngeal mucositis AE CTCAE: E13416 a laryngeal mucositis AE that has moderate discomfort; altered oral intake YH, MW Grade 2 laryngeal mucositis AE CTCAE: E13417 a laryngeal mucositis AE that has severe pain; severely altered eating/swallowing; medical intervention indicated YH, MW Grade 3 laryngeal mucositis AE CTCAE: E13418 a laryngeal mucositis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 laryngeal mucositis AE CTCAE: E13419 a laryngeal obstruction AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL YH, MW Grade 2 laryngeal obstruction AE CTCAE: E13423 a laryngeal obstruction AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) YH, MW Grade 3 laryngeal obstruction AE CTCAE: E13424 a laryngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) YH, MW Grade 2 laryngeal stenosis AE CTCAE: E13429 a laryngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) YH, MW Grade 3 laryngeal stenosis AE CTCAE: E13430 a laryngopharyngeal dysesthesia AE that has moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and or anxiolytic indicated; limiting instrumental ADL YH, MW Grade 2 laryngopharyngeal dysesthesia AE CTCAE: E13435 a laryngopharyngeal dysesthesia AE that has severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL YH, MW Grade 3 laryngopharyngeal dysesthesia AE CTCAE: E13436 a laryngospasm AE that has transient episode; intervention not indicated YH, MW Grade 2 laryngospasm AE CTCAE: E13440 a laryngospasm AE that has recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage) YH, MW Grade 3 laryngospasm AE CTCAE: E13441 a laryngospasm AE that has persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection) YH, MW Grade 4 laryngospasm AE CTCAE: E13442 a pharyngeal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL YH, MW Grade 2 pharyngeal fistula AE CTCAE: E13456 a pharyngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW Grade 3 pharyngeal fistula AE CTCAE: E13457 a pharyngeal mucositis AE that has endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated YH, MW Grade 1 pharyngeal mucositis AE CTCAE: E13467 a pharyngeal mucositis AE that has moderate pain and analgesics indicated; altered oral intake; limiting instrumental ADL YH, MW Grade 2 pharyngeal mucositis AE CTCAE: E13468 a pharyngeal mucositis AE that has severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL YH, MW Grade 3 pharyngeal mucositis AE CTCAE: E13469 a pharyngeal necrosis AE that has inability to aliment adequately by GI tract; tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated YH, MW Grade 3 pharyngeal necrosis AE CTCAE: E13473 a pharyngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL YH, MW Grade 2 pharyngeal stenosis AE CTCAE: E13478 a pharyngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) YH, MW Grade 3 pharyngeal stenosis AE CTCAE: E13479 a pharyngeal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 pharyngeal stenosis AE CTCAE: E13480 a pulmonary fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL YH, MW Grade 2 pulmonary fistula AE CTCAE: E13535 a pulmonary fistula AE that has limiting self care ADL; endoscopic stenting or operative intervention indicated YH, MW Grade 3 pulmonary fistula AE CTCAE: E13536 a retinoic acid syndrome AE that has fluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated YH, MW Grade 1 retinoic acid syndrome AE CTCAE: E13555 a sleep apnea AE that has snoring and nocturnal sleep arousal without apneic periods YH, MW Grade 1 sleep apnea AE CTCAE: E13567 a sleep apnea AE that has moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL YH, MW Grade 2 sleep apnea AE CTCAE: E13568 a sleep apnea AE that has oxygen desaturation; associated with hypertension; medical intervention indicated; limiting self care ADL YH, MW Grade 3 sleep apnea AE CTCAE: E13569 a sleep apnea AE that has cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated YH, MW Grade 4 sleep apnea AE CTCAE: E13570 a tracheal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL YH, MW Grade 2 tracheal fistula AE CTCAE: E13585 a tracheal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW Grade 3 tracheal fistula AE CTCAE: E13586 a tracheal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) YH, MW Grade 4 tracheal fistula AE CTCAE: E13587 a tracheal mucositis AE that has endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms YH, MW Grade 1 tracheal mucositis AE CTCAE: E13590 a tracheal mucositis AE that has severe pain; hemorrhage or respiratory symptoms; limiting self care ADL YH, MW Grade 3 tracheal mucositis AE CTCAE: E13592 a tracheal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) YH, MW Grade 2 tracheal stenosis AE CTCAE: E13597 a tracheal stenosis AE that has stridor or respiratory distress limiting self care ADL; endoscopic intervention indicated (e.g., stent, laser) YH, MW Grade 3 tracheal stenosis AE CTCAE: E13598 a tracheal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 tracheal stenosis AE CTCAE: E13599 an azoospermia AE that has absence of sperm in ejaculate YH, MW Grade 3 azoospermia AE CTCAE: E13068 A breast atrophy AE that has asymmetry >1/3 of breast volume; severe atrophy YH, MW Grade 3 breast atrophy AE CTCAE: E13072 an ejaculation disorder AE that has diminished ejaculation YH, MW Grade 1 ejaculation disorder AE CTCAE: E13086 an ejaculation disorder AE that has anejaculation or retrograde ejaculation YH, MW Grade 2 ejaculation disorder AE CTCAE: E13087 a genital edema AE that has mild swelling or obscuration of anatomic architecture on close inspection YH, MW Grade 1 genital edema AE CTCAE: E13112 a genital edema AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour YH, MW Grade 2 genital edema AE CTCAE: E13113 a genital edema AE that has lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL YH, MW Grade 3 genital edema AE CTCAE: E13114 a gynecomastia AE that has asymptomatic breast enlargement YH, MW Grade 1 gynecomastia AE CTCAE: E13116 a gynecomastia AE that has symptomatic (e.g., pain or psychosocial impact) YH, MW Grade 2 gynecomastia AE CTCAE: E13117 a hematosalpinx AE that has minimal bleeding identified on imaging study or laparoscopy; intervention not indicated YH, MW Grade 1 hematosalpinx AE CTCAE: E13120 an irregular menstruation AE that has intermittent menses with skipped menses for no more than 1 to 3 months YH, MW Grade 1 irregular menstruation AE CTCAE: E13126 an irregular menstruation AE that has intermittent menses with skipped menses for more than 4 to 6 months YH, MW Grade 2 irregular menstruation AE CTCAE: E13127 an irregular menstruation AE that has persistent amenorrhea for more than 6 months YH, MW Grade 3 irregular menstruation AE CTCAE: E13128 a lactation disorder AE that has mild changes in lactation, not significantly affecting production or expression of breast milk YH, MW Grade 1 lactation disorder AE CTCAE: E13130 a lactation disorder AE that has changes in lactation, significantly affecting breast production or expression of breast milk YH, MW Grade 2 lactation disorder AE CTCAE: E13131 a nipple deformity AE that has asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex YH, MW Grade 1 nipple deformity AE CTCAE: E13139 a nipple deformity AE that has symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex YH, MW Grade 2 nipple deformity AE CTCAE: E13140 an oligospermia AE requires sperm concentration >48 million/mL or motility >68% YH, MW Grade 1 oligospermia AE CTCAE: E13142 an oligospermia AE requires sperm concentration 13 - 48 million/mL or motility 32 - 68% YH, MW Grade 2 oligospermia AE CTCAE: E13143 an oligospermia AE requires sperm concentration <13 million/mL or motility <32% YH, MW Grade 3 oligospermia AE CTCAE: E13144 a testicular disorder AE that has symptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL YH, MW Grade 2 testicular disorder AE CTCAE: E13217 a testicular disorder AE that has severe symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated YH, MW Grade 3 testicular disorder AE CTCAE: E13218 a vaginal discharge AE that has mild vaginal discharge (greater than baseline for patient) YH, MW Grade 1 vaginal discharge AE CTCAE: E13252 a vaginal discharge AE that has moderate to heavy vaginal discharge; use of perineal pad or tampon indicated YH, MW Grade 2 vaginal discharge AE CTCAE: E13253 a bladder spasm AE that has antispasmodics indicated YH, MW Grade 2 bladder spasm AE CTCAE: E12986 a bladder spasm AE that has hospitalization indicated YH, MW Grade 3 bladder spasm AE CTCAE: E12987 a chronic kidney disease AE that requires eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN - 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5 YH, MW Grade 1 chronic kidney disease AE CTCAE: E12989 a chronic kidney disease AE that requires eGFR or CrCl 59 - 30 ml/min/1.73 m2 YH, MW Grade 2 chronic kidney disease AE CTCAE: E12990 a chronic kidney disease AE that requires eGFR or CrCl 29 - 15 ml/min/1.73 m2 YH, MW Grade 3 chronic kidney disease AE CTCAE: E12991 a chronic kidney disease AE that requires eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated YH, MW Grade 4 chronic kidney disease AE CTCAE: E12992 a cystitis noninfective AE that has microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence YH, MW Grade 1 cystitis noninfective AE CTCAE: E12995 a cystitis noninfective AE that has moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL YH, MW Grade 2 cystitis noninfective AE CTCAE: E12996 a cystitis noninfective AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated YH, MW Grade 3 cystitis noninfective AE CTCAE: E12997 a proteinuria AE that requires 1+ proteinuria; urinary protein <1.0 g/24 hrs YH, MW Grade 1 proteinuria AE CTCAE: E13009 a proteinuria AE that requires YH, MW Grade 2 proteinuria AE CTCAE: E13010 a proteinuria AE that requires YH, MW Grade 3 proteinuria AE CTCAE: E13011 a renal calculi AE that has asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated YH, MW Grade 1 renal calculi AE CTCAE: E13019 a renal calculi AE that has symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated YH, MW Grade 2 renal calculi AE CTCAE: E13020 a renal calculi AE that has hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated YH, MW Grade 3 renal calculi AE CTCAE: E13021 an urinary fistula AE that has noninvasive intervention indicated; urinary or suprapubic catheter placement indicated YH, MW Grade 2 urinary fistula AE CTCAE: E13035 an urinary fistula AE that has limiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated YH, MW Grade 3 urinary fistula AE CTCAE: E13036 an urinary tract obstruction AE that has symptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated YH, MW Grade 2 urinary tract obstruction AE CTCAE: E13054 an urinary tract obstruction AE that has symptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic or operative intervention indicated YH, MW Grade 3 urinary tract obstruction AE CTCAE: E13055 a mania AE that has mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep) YH, MW Grade 1 mania AE CTCAE: E12937 a mania AE that has moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene) YH, MW Grade 2 mania AE CTCAE: E12938 a mania AE that has severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated YH, MW Grade 3 mania AE CTCAE: E12939 a fetal growth retardation AE that has <10% percentile of weight for gestational age YH, MW Grade 2 fetal growth retardation AE CTCAE: E12858 a fetal growth retardation AE that has <5% percentile of weight for gestational age YH, MW Grade 3 fetal growth retardation AE CTCAE: E12859 a fetal growth retardation AE that has <1% percentile of weight for gestational age YH, MW Grade 4 fetal growth retardation AE CTCAE: E12860 a premature delivery AE that has delivery of a liveborn infant at >34 to 37 weeks gestation YH, MW Grade 1 premature delivery AE CTCAE: E12868 a premature delivery AE that has delivery of a liveborn infant at >28 to 34 weeks gestation YH, MW Grade 2 premature delivery AE CTCAE: E12869 a premature delivery AE that has delivery of a liveborn infant at 24 to 28 weeks gestation YH, MW Grade 3 premature delivery AE CTCAE: E12870 a premature delivery AE that has delivery of a liveborn infant at 24 weeks of gestation or less YH, MW Grade 4 premature delivery AE CTCAE: E12871 a spasticity AE that has mild or slight increase in muscle tone YH, MW Grade 1 spasticity AE CTCAE: E12821 a spasticity AE that has moderate increase in muscle tone and increase in resistance through range of motion YH, MW Grade 2 spasticity AE CTCAE: E12822 a spasticity AE that has severe increase in muscle tone and increase in resistance through range of motion YH, MW Grade 3 spasticity AE CTCAE: E12823 a spasticity AE that has life-threatening; unable to move active or passive range of motion YH, MW Grade 4 spasticity AE CTCAE: E12824 a treatment related secondary malignancy AE that has non life-threatening secondary malignancy YH, MW Grade 3 treatment related secondary malignancy AE CTCAE: E12562 a treatment related secondary malignancy AE that has acute life-threatening secondary malignancy; blast crisis in leukemia YH, MW Grade 4 treatment related secondary malignancy AE CTCAE: E12563 an abdominal soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) YH, MW Grade 2 abdominal soft tissue necrosis AE CTCAE: E12370 an abdominal soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g. tissue reconstruction, flap or grafting) YH, MW Grade 3 abdominal soft tissue necrosis AE CTCAE: E12371 a fibrosis deep connective tissue AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) YH, MW Grade 1 fibrosis deep connective tissue AE CTCAE: E12409 a fibrosis deep connective tissue AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL YH, MW Grade 2 fibrosis deep connective tissue AE CTCAE: E12410 a fibrosis deep connective tissue AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g. mouth, anus); limiting self care ADL YH, MW Grade 3 fibrosis deep connective tissue AE CTCAE: E12411 a fibrosis deep connective tissue AE that has generalized; associated with signs or symptoms of impaired breathing or feeding YH, MW Grade 4 fibrosis deep connective tissue AE CTCAE: E12412 a growth suppression AE that has reduction in growth velocity by 10 - 29% ideally measured over the period of a year YH, MW Grade 1 growth suppression AE CTCAE: E12423 a growth suppression AE that has reduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve YH, MW Grade 2 growth suppression AE CTCAE: E12424 a growth suppression AE that has reduction in growth velocity of >=50% ideally measured over the period of a year YH, MW Grade 3 growth suppression AE CTCAE: E12425 a head soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) YH, MW Grade 2 head soft tissue necrosis AE CTCAE: E12427 a head soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 3 head soft tissue necrosis AE CTCAE: E12428 a joint range of motion decreased cervical spine AE that has mild restriction of rotation or flexion between 60 - 70 degrees YH, MW Grade 1 joint range of motion decreased cervical spine AE CTCAE: E12440 a joint range of motion decreased cervical spine AE that has rotation <60 degrees to right or left; <60 degrees of flexion YH, MW Grade 2 joint range of motion decreased cervical spine AE CTCAE: E12441 a joint range of motion decreased cervical spine AE that has ankylosed/fused over multiple segments with no C-spine rotation YH, MW Grade 3 joint range of motion decreased cervical spine AE CTCAE: E12442 a joint range of motion decreased lumbar spine AE that has stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity YH, MW Grade 1 joint range of motion decreased lumbar spine AE CTCAE: E12444 a joint range of motion decreased lumbar spine AE that has pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor YH, MW Grade 2 joint range of motion decreased lumbar spine AE CTCAE: E12445 a joint range of motion decreased lumbar spine AE that requires <50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object) YH, MW Grade 3 joint range of motion decreased lumbar spine AE CTCAE: E12446 a neck soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) YH, MW Grade 2 neck soft tissue necrosis AE CTCAE: E12498 a neck soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 3 neck soft tissue necrosis AE CTCAE: E12499 a pelvic soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) YH, MW Grade 2 pelvic soft tissue necrosis AE CTCAE: E12517 a pelvic soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 3 pelvic soft tissue necrosis AE CTCAE: E12518 a scoliosis AE that requires <20 degrees; clinically undetectable YH, MW Grade 1 scoliosis AE CTCAE: E12522 a scoliosis AE that requires >20 - 45 degrees; visible by forward flexion; limiting instrumental ADL YH, MW Grade 2 scoliosis AE CTCAE: E12523 a scoliosis AE that requires >45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL; disabling YH, MW Grade 3 scoliosis AE CTCAE: E12524 a soft tissue necrosis lower limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) YH, MW Grade 2 soft tissue necrosis lower limb AE CTCAE: E12526 a soft tissue necrosis lower limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 3 soft tissue necrosis lower limb AE CTCAE: E12527 a soft tissue necrosis upper limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) YH, MW Grade 2 soft tissue necrosis upper limb AE CTCAE: E12531 a soft tissue necrosis upper limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 3 soft tissue necrosis upper limb AE CTCAE: E12532 a Superficial soft tissue fibrosis AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) YH, MW Grade 1 superficial soft tissue fibrosis AE CTCAE: E12536 a Superficial soft tissue fibrosis AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL YH, MW Grade 2 superficial soft tissue fibrosis AE CTCAE: E12537 a Superficial soft tissue fibrosis AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL YH, MW Grade 3 superficial soft tissue fibrosis AE CTCAE: E12538 a superficial soft tissue fibrosis AE that has generalized; associated with signs or symptoms of impaired breathing or feeding YH, MW Grade 4 superficial soft tissue fibrosis AE CTCAE: E12539 a trismus AE that has decreased ROM (range of motion) without impaired eating YH, MW Grade 1 trismus AE CTCAE: E12542 a trismus AE that has decreased ROM requiring small bites, soft foods or purees YH, MW Grade 2 trismus AE CTCAE: E12543 a trismus AE that has decreased ROM with inability to adequately aliment or hydrate orally YH, MW Grade 3 trismus AE CTCAE: E12544 An unequal limb length AE that has mild length discrepancy <2 cm YH, MW Grade 1 unequal limb length AE CTCAE: E12546 An unequal limb length AE that has moderate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL YH, MW Grade 2 unequal limb length AE CTCAE: E12547 An unequal limb length AE that has severe length discrepancy >5 cm; limiting self care ADL; disabling; operative intervention indicated YH, MW Grade 3 unequal limb length AE CTCAE: E12548 a alkalosis AE that requires pH >normal, but <=7.5 YH, MW Grade 1 alkalosis AE CTCAE: E12248 a alkalosis AE that requires pH >7.5 YH, MW Grade 3 alkalosis AE CTCAE: E12249 a glucose intolerance AE that has symptomatic; dietary modification or oral agent indicated YH, MW Grade 2 glucose intolerance AE CTCAE: E12266 a glucose intolerance AE that has severe symptoms; insulin indicated YH, MW Grade 3 glucose intolerance AE CTCAE: E12267 a hypermagnesemia AE that requires >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L YH, MW Grade 1 hypermagnesemia AE CTCAE: E12289 a hypermagnesemia AE that requires >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L YH, MW Grade 3 hypermagnesemia AE CTCAE: E12290 a hypermagnesemia AE that requires >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences YH, MW Grade 4 hypermagnesemia AE CTCAE: E12291 a hypernatremia AE that requires >ULN - 150 mmol/L YH, MW Grade 1 hypernatremia AE CTCAE: E12294 a hypernatremia AE that requires >150 - 155 mmol/L YH, MW Grade 2 hypernatremia AE CTCAE: E12295 a hypernatremia AE that requires >155 - 160 mmol/L; hospitalization indicated YH, MW Grade 3 hypernatremia AE CTCAE: E12296 a hypernatremia AE that requires >160 mmol/L; life-threatening consequences YH, MW Grade 4 hypernatremia AE CTCAE: E12297 a hypokalemia AE that requires <LLN - 3.0 mmol/L YH, MW Grade 1 hypokalemia AE CTCAE: E12328 a hypokalemia AE that requires <LLN - 3.0 mmol/L; symptomatic; intervention indicated YH, MW Grade 2 hypokalemia AE CTCAE: E12329 a hypokalemia AE that requires <3.0 - 2.5 mmol/L; hospitalization indicated YH, MW Grade 3 hypokalemia AE CTCAE: E12330 a hypokalemia AE that requires <2.5 mmol/L; life-threatening consequences YH, MW Grade 4 hypokalemia AE CTCAE: E12331 a hyponatremia AE that requires <LLN - 130 mmol/L YH, MW Grade 1 hyponatremia AE CTCAE: E12340 a hyponatremia AE that requires <130 - 120 mmol/L YH, MW Grade 3 hyponatremia AE CTCAE: E12341 a hyponatremia AE that requires <120 mmol/L; life-threatening consequences YH, MW Grade 4 hyponatremia AE CTCAE: E12342 an obesity AE that requires BMI 25 - 29.9 kg/m2 YH, MW Grade 2 obesity AE CTCAE: E12362 an obesity AE that requires BMI 30 - 39.9 kg/m2 YH, MW Grade 3 obesity AE CTCAE: E12363 an obesity AE that requires BMI >=40 kg/m2 YH, MW Grade 4 obesity AE CTCAE: E12364 a flushing AE that has symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL YH, MW Grade 3 flushing AE CTCAE: E13774 a hematoma AE that requires minimally invasive evacuation or aspiration YH, MW Grade 2 hematoma AE CTCAE: E13777 a hematoma AE that requires transfusion, radiologic, endoscopic, or elective operative intervention YH, MW Grade 3 hematoma AE CTCAE: E13778 an hypertension AE that has prehypertension (systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg) YH, MW Grade 1 hypertension AE CTCAE: E13786 an hypertension AE that for Adult: has stage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated; for Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated. YH, MW Grade 2 hypertension AE CTCAE: E13787 an hypertension AE that for Adult has Stage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; for Pediatric: Same as adult. YH, MW Grade 3 hypertension AE CTCAE: E13788 an hypertension AE that for Adult has life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated; for Pediatric: Same as adult YH, MW Grade 4 hypertension AE CTCAE: E13789 a peripheral ischaemia AE that has brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit YH, MW Grade 2 peripheral ischemia AE CTCAE: E13811 a peripheral ischaemia AE that has a recurring or prolonged (>=24 hrs) and/or invasive intervention indicated YH, MW Grade 3 peripheral ischemia AE CTCAE: E13812 a vasculitis AE that shows severe symptoms, medical intervention indicated (e.g., steroids) YH, MW Grade 3 vasculitis AE CTCAE: E13840 a vasculitis AE that shows threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated YH, MW Grade 4 vasculitis AE CTCAE: E13841 an alopecia AE that has hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage YH, MW Grade 1 alopecia AE CTCAE: E13612 an alopecia AE that has hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact YH, MW Grade 2 alopecia AE CTCAE: E13613 a dry skin AE that is coverying <10% BSA and no associated erythema or pruritus YH, MW Grade 1 dry skin AE CTCAE: E13624 a dry skin AE that is coverying 10 - 30% BSA and associated with erythema or pruritus; limiting instrumental ADL YH, MW Grade 2 dry skin AE CTCAE: E13625 a dry skin AE that is coverying >30% BSA and associated with pruritus; limiting self care ADL YH, MW Grade 3 dry skin AE CTCAE: E13626 an erythema multiforme AE that has target lesions covering <10% BSA and not associated with skin tenderness YH, MW Grade 1 erythema multiforme AE CTCAE: E13628 an erythema multiforme AE that has target lesions covering 10 - 30% BSA and associated with skin tenderness YH, MW Grade 2 erythema multiforme AE CTCAE: E13629 an erythema multiforme AE that has target lesions covering >30% BSA and associated with oral or genital erosions YH, MW Grade 3 erythema multiforme AE CTCAE: E13630 an erythema multiforme AE that has target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated YH, MW Grade 4 erythema multiforme AE CTCAE: E13631 a hyperhidros AE that shows limited to one site (palms, soles, or axillae); self care interventions YH, MW Grade 1 hyperhidrosis AE CTCAE: E13646 a hyperhidros AE that has Involving >1 site; patient seeks medical intervention; associated with psychosocial impact YH, MW Grade 2 hyperhidrosis AE CTCAE: E13647 a hyperhidros AE that has Generalized involving sites other than palms, soles, or axillae; associated with electrolyte/hemodynamic imbalance YH, MW Grade 3 hyperhidrosis AE CTCAE: E13648 a palmar-plantar erythrodysesthesia syndrome AE that has minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain YH, MW Grade 1 palmar-plantar erythrodysesthesia syndrome AE CTCAE: E13673 a palmar-plantar erythrodysesthesia syndrome AE that has skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL YH, MW Grade 2 palmar-plantar erythrodysesthesia syndrome AE CTCAE: E13674 a palmar-plantar erythrodysesthesia syndrome AE that has severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care ADL YH, MW Grade 3 palmar-plantar erythrodysesthesia syndrome AE CTCAE: E13675 a periorbital edema AE that has soft or non-pitting YH, MW Grade 1 periorbital edema AE CTCAE: E13677 a periorbital edema AE that has indurated or pitting edema; topical intervention indicated YH, MW Grade 2 periorbital edema AE CTCAE: E13678 a periorbital edema AE that has edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated YH, MW Grade 3 periorbital edema AE CTCAE: E13679 a photosensitivity reaction AE that has painless erythema and erythema covering <10% BSA YH, MW Grade 1 photosensitivity AE CTCAE: E13681 a photosensitivity reaction AE that has tender erythema covering 10 - 30% BSA YH, MW Grade 2 photosensitivity AE CTCAE: E13682 a photosensitivity reaction AE that has erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs) YH, MW Grade 3 photosensitivity AE CTCAE: E13683 a pruritus AE that has mild or localized; topical intervention indicated YH, MW Grade 1 pruritus AE CTCAE: E13687 a pruritus AE that has intense or widespread; intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL YH, MW Grade 2 pruritus AE CTCAE: E13688 a pruritus AE that has intense or widespread; constant; limiting self care ADL or sleep; oral corticosteroid or immunosuppressive therapy indicated YH, MW Grade 3 pruritus AE CTCAE: E13689 a purpura AE that has combined area of lesions covering <10% BSA YH, MW Grade 1 purpura AE CTCAE: E13691 a purpura AE that has combined area of lesions covering 10 - 30% BSA; bleeding with trauma YH, MW Grade 2 purpura AE CTCAE: E13692 a purpura AE that has combined area of lesions covering >30% BSA; spontaneous bleeding YH, MW Grade 3 purpura AE CTCAE: E13693 a skin atrophy AE that has covering <10% BSA; associated with telangiectasias or changes in skin color YH, MW Grade 1 skin atrophy AE CTCAE: E13715 a skin atrophy AE that has covering 10 - 30% BSA; associated with striae or adnexal structure loss YH, MW Grade 2 skin atrophy AE CTCAE: E13716 a skin atrophy AE that has covering >30% BSA; associated with ulceration YH, MW Grade 3 skin atrophy AE CTCAE: E13717 a skin hyperpigmentation AE that has hyperpigmentation covering <10% BSA; no psychosocial impact YH, MW Grade 1 skin hyperpigmentation AE CTCAE: E13719 a skin hyperpigmentation AE that has hyperpigmentation covering >10% BSA; associated psychosocial impact YH, MW Grade 2 skin hyperpigmentation AE CTCAE: E13720 a skin hypopigmentation AE that has hypopigmentation or depigmentation covering <10% BSA; no psychosocial impact YH, MW Grade 1 skin hypopigmentation AE CTCAE: E13722 a skin hypopigmentation AE that has hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact YH, MW Grade 2 skin hypopigmentation AE CTCAE: E13723 a stevens-johnson syndrome AE that has skin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) YH, MW Grade 3 stevens-Johnson syndrome AE CTCAE: E13737 a stevens-johnson syndrome AE that has skin sloughing covering 10 - 30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) YH, MW Grade 4 stevens-Johnson syndrome AE CTCAE: E13738 a telangiectasia AE that has telangiectasias covering <10% BSA YH, MW Grade 1 telangiectasia AE CTCAE: E13741 a telangiectasia AE that has telangiectasias covering >10% BSA; associated with psychosocial impact YH, MW Grade 2 telangiectasia AE CTCAE: E13742 a toxic epidermal necrolysis AE that has skin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment) YH, MW Grade 4 toxic epidermal necrolysis AE CTCAE: E13744 an urticaria AE that has urticarial lesions covering <10% BSA; topical intervention indicated YH, MW Grade 1 urticaria AE CTCAE: E13747 an urticaria AE that has urticarial lesions covering 10 - 30% BSA; oral intervention indicated YH, MW Grade 2 urticaria AE CTCAE: E13748 an urticaria AE that has urticariallesions covering >30% BSA; IV intervention indicated YH, MW Grade 3 urticaria AE CTCAE: E13749 an aspiration AE that has altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen) YH, MW Grade 2 aspiration AE CTCAE: E13312 an aspiration AE that has dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally YH, MW Grade 3 aspiration AE CTCAE: E13313 an atelectasis AE that has symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning YH, MW Grade 2 atelectasis AE CTCAE: E13318 an atelectasis AE that has oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser) YH, MW Grade 3 atelectasis AE CTCAE: E13319 a chylothorax AE that has symptomatic; thoracentesis or tube drainage indicated YH, MW Grade 2 chylothorax AE CTCAE: E13360 a chylothorax AE that has severe symptoms; elective operative intervention indicated YH, MW Grade 3 chylothorax AE CTCAE: E13361 an epistaxis AE that has moderate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors) YH, MW Grade 2 epistaxis AE CTCAE: E13376 a Hiccups AE that has interfering with sleep; limiting self care ADL YH, MW Grade 3 hiccups AE CTCAE: E13383 a hoarseness AE that has mild or intermittent voice change; fully understandable; self-resolves YH, MW Grade 1 hoarseness AE CTCAE: E13385 a hoarseness AE that has Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated YH, MW Grade 2 hoarseness AE CTCAE: E13386 a hoarseness AE that has severe voice changes including predominantly whispered speech YH, MW Grade 3 hoarseness AE CTCAE: E13387 a hypoxia AE that has decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen YH, MW Grade 2 hypoxia AE CTCAE: E13389 a hypoxia AE that has decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg) YH, MW Grade 3 hypoxia AE CTCAE: E13390 a hypoxia AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 hypoxia AE CTCAE: E13391 a laryngeal edema AE that has stridor; respiratory distress; hospitalization indicated YH, MW Grade 3 laryngeal edema AE CTCAE: E13396 a laryngeal edema AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 laryngeal edema AE CTCAE: E13397 a pleural effusion AE that has symptomatic; intervention indicated (e.g., diuretics or limited therapeutic thoracentesis) YH, MW Grade 2 pleural effusion AE CTCAE: E13488 a pleural effusion AE that has symptomatic with respiratory distress and hypoxia; surgical intervention including chest tube or pleurodesis indicated YH, MW Grade 3 pleural effusion AE CTCAE: E13489 a pleural hemorrhage AE that has asymptomatic; mild hemorrhage confirmed by thoracentesis YH, MW Grade 1 pleural hemorrhage AE CTCAE: E13493 a pleural hemorrhage AE that has symptomatic or associated with pneumothorax; chest tube drainage indicated YH, MW Grade 2 pleural hemorrhage AE CTCAE: E13494 a pleural hemorrhage AE that has >1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2 - 4 hr); persistent transfusion indicated; elective operative intervention indicated YH, MW Grade 3 pleural hemorrhage AE CTCAE: E13495 a pneumonitis AE that has severe symptoms; limiting self care ADL; oxygen indicated YH, MW Grade 3 pneumonitis AE CTCAE: E13505 a pneumonitis AE that has life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 pneumonitis AE CTCAE: E13506 a pneumothorax AE that has symptomatic; intervention indicated (e.g., tube placement without sclerosis) YH, MW Grade 2 pneumothorax AE CTCAE: E13510 a pneumothorax AE that has sclerosis and/or operative intervention indicated; hospitalization indicated YH, MW Grade 3 pneumothorax AE CTCAE: E13511 a productive cough AE that has occasional/minimal production of sputum with cough YH, MW Grade 1 productive cough AE CTCAE: E13518 a productive cough AE that has moderate sputum production; limiting instrumental ADL YH, MW Grade 2 productive cough AE CTCAE: E13519 a productive cough AE that has persistent or copious production of sputum; limiting self care ADL YH, MW Grade 3 productive cough AE CTCAE: E13520 a pulmonary edema AE that has radiologic findings only; minimal dyspnea on exertion YH, MW Grade 1 pulmonary edema AE CTCAE: E13522 a pulmonary edema AE that has moderate dyspnea on exertion; medical intervention indicated; limiting instrumental ADL YH, MW Grade 2 pulmonary edema AE CTCAE: E13523 a pulmonary edema AE that has severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL YH, MW Grade 3 pulmonary edema AE CTCAE: E13524 a pulmonary edema AE that has life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated YH, MW Grade 4 pulmonary edema AE CTCAE: E13525 a pulmonary fibrosis AE that has mild hypoxemia; radiologic pulmonary fibrosis <25% of lung volume YH, MW Grade 1 pulmonary fibrosis AE CTCAE: E13528 a pulmonary fibrosis AE that has moderate hypoxemia; evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 - 50% YH, MW Grade 2 pulmonary fibrosis AE CTCAE: E13529 a pulmonary fibrosis AE that has severe hypoxemia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50 - 75% YH, MW Grade 3 pulmonary fibrosis AE CTCAE: E13530 a pulmonary fibrosis AE that has life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing YH, MW Grade 4 pulmonary fibrosis AE CTCAE: E13531 a pulmonary hypertension AE that has minimal dyspnea; findings on physical exam or other evaluation YH, MW Grade 1 pulmonary hypertension AE CTCAE: E13540 a pulmonary hypertension AE that has moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention YH, MW Grade 2 pulmonary hypertension AE CTCAE: E13541 a pulmonary hypertension AE that has severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated YH, MW Grade 3 pulmonary hypertension AE CTCAE: E13542 a pulmonary hypertension AE that has life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 pulmonary hypertension AE CTCAE: E13543 a sinus disorder AE that has asymptomatic mucosal crusting; blood-tinged secretions YH, MW Grade 1 sinus disorder AE CTCAE: E13561 a sinus disorder AE that has symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL YH, MW Grade 2 sinus disorder AE CTCAE: E13562 a sinus disorder AE that has stenosis with significant nasal obstruction; limiting self care ADL YH, MW Grade 3 sinus disorder AE CTCAE: E13563 a sinus disorder AE that has necrosis of soft tissue or bone; urgent operative intervention indicated YH, MW Grade 4 sinus disorder AE CTCAE: E13564 a sore throat AE that has Severe pain; limiting self care ADL; limiting ability to swallow YH, MW Grade 3 sore throat AE CTCAE: E13578 a stridor AE that has respiratory distress limiting self care ADL; medical intervention indicated YH, MW Grade 3 stridor AE CTCAE: E13580 a stridor AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 4 stridor AE CTCAE: E13581 a voice alteration AE that has mild or intermittent change from normal voice YH, MW Grade 1 voice alteration AE CTCAE: E13602 a voice alteration AE that has moderate or persistent change from normal voice; still understandable YH, MW Grade 2 voice alteration AE CTCAE: E13603 a voice alteration AE that has severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology YH, MW Grade 3 voice alteration AE CTCAE: E13604 a wheezing AE that has detectable airway noise with minimal symptoms YH, MW Grade 1 wheezing AE CTCAE: E13606 a wheezing AE that has severe respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated YH, MW Grade 3 wheezing AE CTCAE: E13608 a menorrhagia AE that has moderate symptoms; medical intervention indicated (e.g., hormones) YH, MW Grade 2 menorrhagia AE CTCAE: E13134 a menorrhagia AE that has severe; transfusion indicated; surgical intervention indicated (e.g., hysterectomy) YH, MW Grade 3 menorrhagia AE CTCAE: E13135 an acute kidney injury AE that has creatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline YH, MW Grade 1 acute kidney injury AE CTCAE: E12974 an acute kidney injury AE that has creatinine 2 - 3 x above baseline YH, MW Grade 2 acute kidney injury AE CTCAE: E12975 an acute kidney injury AE that has creatinine >3 x baseline or >4.0 mg/dL; hospitalization indicated YH, MW Grade 3 acute kidney injury AE CTCAE: E12976 a hematuria AE that has symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL YH, MW Grade 2 hematuria AE CTCAE: E13002 a hematuria AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated; limiting self care ADL YH, MW Grade 3 hematuria AE CTCAE: E13003 an urinary incontinence AE that has occasional (e.g., with coughing, sneezing, etc.), pads not indicated YH, MW Grade 1 urinary incontinence AE CTCAE: E13043 an urinary incontinence AE that has spontaneous; pads indicated; limiting instrumental ADL YH, MW Grade 2 urinary incontinence AE CTCAE: E13044 an urinary incontinence AE that has Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL YH, MW Grade 3 urinary incontinence AE CTCAE: E13045 an urinary retention AE that has urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual YH, MW Grade 1 urinary retention AE CTCAE: E13047 an urinary retention AE that has placement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated YH, MW Grade 2 urinary retention AE CTCAE: E13048 an urinary retention AE that has elective operative or radiologic intervention indicated; substantial loss of affected kidney function or mass YH, MW Grade 3 urinary retention AE CTCAE: E13049 a suicidal ideation AE that has increased thoughts of death but no wish to kill oneself YH, MW Grade 1 suicidal ideation AE CTCAE: E12965 a suicidal ideation AE that has suicidal ideation with no specific plan or intent YH, MW Grade 2 suicidal ideation AE CTCAE: E12966 a suicidal ideation AE that has specific plan to commit suicide without serious intent to die which may not require hospitalization YH, MW Grade 3 suicidal ideation AE CTCAE: E12967 a suicidal ideation AE that has specific plan to commit suicide with serious intent to die which requires hospitalization YH, MW Grade 4 suicidal ideation AE CTCAE: E12968 a suicide attempt AE that has suicide attempt or gesture without intent to die which may not require hospitalization YH, MW Grade 3 suicide attempt AE CTCAE: E12970 a suicide attempt AE that has suicide attempt with intent to die which requires hospitalization YH, MW Grade 4 suicide attempt AE CTCAE: E12971 an aphonia AE that has voicelessness; unable to speak YH, MW Grade 3 aphonia AE CTCAE: E12590 a depressed level of consciousness AE that has decreased level of alertness YH, MW Grade 1 depressed level of consciousness AE CTCAE: E12626 a depressed level of consciousness AE that has Sedation; slow response to stimuli; limiting instrumental ADL YH, MW Grade 2 depressed level of consciousness AE CTCAE: E12627 a depressed level of consciousness AE that is difficult to arouse YH, MW Grade 3 depressed level of consciousness AE CTCAE: E12628 a dysgenusia AE that has altered taste but no change in diet YH, MW Grade 1 dysgeusia AE CTCAE: E12644 a dysgenusia AE that has altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste YH, MW Grade 2 dysgeusia AE CTCAE: E12645 a leukoencephalopathy AE that has asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly YH, MW Grade 1 leukoencephalopathy AE CTCAE: E12713 a leukoencephalopathy AE that has moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly YH, MW Grade 2 leukoencephalopathy AE CTCAE: E12714 a leukoencephalopathy AE that has severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly YH, MW Grade 3 leukoencephalopathy AE CTCAE: E12715 a leukoencephalopathy AE that has life-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly YH, MW Grade 4 leukoencephalopathy AE CTCAE: E12716 a myelitis AE that has asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign) YH, MW Grade 1 myelitis AE CTCAE: E12733 a myelitis AE that has moderate weakness or sensory loss; limiting instrumental ADL YH, MW Grade 2 myelitis AE CTCAE: E12734 a myelitis AE that has severe weakness or sensory loss; limiting self care ADL YH, MW Grade 3 myelitis AE CTCAE: E12735 a presyncope AE that has present (e.g., near fainting) YH, MW Grade 2 presyncope AE CTCAE: E12779 a seizure AE that has brief partial seizure; no loss of consciousness YH, MW Grade 1 seizure AE CTCAE: E12805 a seizure AE that has brief generalized seizure YH, MW Grade 2 seizure AE CTCAE: E12806 a seizure AE that has multiple seizures despite medical intervention YH, MW Grade 3 seizure AE CTCAE: E12807 a seizure AE that has life-threatening; prolonged repetitive seizures YH, MW Grade 4 seizure AE CTCAE: E12808 a somnolence AE that has mild but more than usual drowsiness or sleepiness YH, MW Grade 1 somnolence AE CTCAE: E12815 a somnolence AE that has moderate sedation; limiting instrumental ADL YH, MW Grade 2 somnolence AE CTCAE: E12816 a somnolence AE that has obtundation or stupor YH, MW Grade 3 somnolence AE CTCAE: E12817 a syncope AE that has fainting; orthostatic collapse YH, MW Grade 3 syncope AE CTCAE: E12833 an arthritis AE that has mild pain with inflammation, erythema, or joint swelling YH, MW Grade 1 arthritis AE CTCAE: E12379 an arthritis AE that has moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL YH, MW Grade 2 arthritis AE CTCAE: E12380 an arthritis AE that has severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; disabling; limiting self care ADL YH, MW Grade 3 arthritis AE CTCAE: E12381 a joint range of motion decreased AE that requires <=25% loss of ROM (range of motion); decreased ROM limiting athletic activity YH, MW Grade 1 joint range of motion decreased AE CTCAE: E12436 a joint range of motion decreased AE that requires >25 - 50% decrease in ROM; limiting instrumental ADL YH, MW Grade 2 joint range of motion decreased AE CTCAE: E12437 a joint range of motion decreased AE that requires >50% decrease in ROM; limiting self care ADL; disabling YH, MW Grade 3 joint range of motion decreased AE CTCAE: E12438 an osteoporosis AE that has radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); no loss of height or intervention indicated YH, MW Grade 1 osteoporosis AE CTCAE: E12509 an osteoporosis AE that has BMD t-score <-2.5; loss of height <2 cm; anti-osteoporotic therapy indicated; limiting instrumental ADL YH, MW Grade 2 osteoporosis AE CTCAE: E12510 an osteoporosis AE that has loss of height >=2 cm; hospitalization indicated; limiting self care ADL YH, MW Grade 3 osteoporosis AE CTCAE: E12511 an acidosis AE that has pH <normal, but >=7.3 YH, MW Grade 1 acidosis AE CTCAE: E12238 an acidosis AE that has pH <7.3 YH, MW Grade 3 acidosis AE CTCAE: E12239 an anorexia AE that has loss of appetite without alteration in eating habits YH, MW Grade 1 anorexia AE CTCAE: E12253 an anorexia AE that has oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated YH, MW Grade 2 anorexia AE CTCAE: E12254 an anorexia AE that has associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated YH, MW Grade 3 anorexia AE CTCAE: E12255 a dehydration AE that has increased oral fluids indicated; dry mucous membranes; diminished skin turgor YH, MW Grade 1 dehydration AE CTCAE: E12259 a dehydration AE that requires IIV fluids indicated <24 hrs YH, MW Grade 2 dehydration AE CTCAE: E12260 a hypercalcemia AE that has corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L YH, MW Grade 1 hypercalcemia AE CTCAE: E12271 a hypercalcemia AE that has corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic YH, MW Grade 2 hypercalcemia AE CTCAE: E12272 a hypercalcemia AE that has corrected serum calcium of >12.5 - 13.5 mg/dL; >3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated YH, MW Grade 3 hypercalcemia AE CTCAE: E12273 a hypercalcemia AE that has corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences YH, MW Grade 4 hypercalcemia AE CTCAE: E12274 a hypeglycemia AE that has fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L YH, MW Grade 1 hyperglycemia AE CTCAE: E12277 a hypeglycemia AE that has fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L YH, MW Grade 2 hyperglycemia AE CTCAE: E12278 a hypeglycemia AE that has >250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated YH, MW Grade 3 hyperglycemia AE CTCAE: E12279 a hypeglycemia AE that has >500 mg/dL; >27.8 mmol/L; life-threatening consequences YH, MW Grade 4 hyperglycemia AE CTCAE: E12280 a hyperkalemia AE that requires >ULN - 5.5 mmol/L YH, MW Grade 1 hyperkalemia AE CTCAE: E12283 a hyperkalemia AE that requires >5.5 - 6.0 mmol/L YH, MW Grade 2 hyperkalemia AE CTCAE: E12284 a hyperkalemia AE that requires >6.0 - 7.0 mmol/L; hospitalization indicated YH, MW Grade 3 hyperkalemia AE CTCAE: E12285 a hyperkalemia AE that requires >7.0 mmol/L; life-threatening consequences YH, MW Grade 4 hyperkalemia AE CTCAE: E12286 a hypertriglyceridemia AE that requires 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L YH, MW Grade 1 hypertriglyceridemia AE CTCAE: E12300 a hypertriglyceridemia AE that requires >300 mg/dL - 500 mg/dL; >3.42 mmol/L - 5.7 mmol/L YH, MW Grade 2 hypertriglyceridemia AE CTCAE: E12301 a hypertriglyceridemia AE that requires >500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L YH, MW Grade 3 hypertriglyceridemia AE CTCAE: E12302 a hypertriglyceridemia AE that requires >1000 mg/dL; >11.4 mmol/L; life-threatening consequences YH, MW Grade 4 hypertriglyceridemia AE CTCAE: E12303 a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) without physiologic consequences YH, MW Grade 1 hyperuricemia AE CTCAE: E12306 a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) with physiologic consequences YH, MW Grade 3 hyperuricemia AE CTCAE: E12307 a hyperuricemia AE that requires >10 mg/dL; >0.59 mmol/L; life-threatening consequences YH, MW Grade 4 hyperuricemia AE CTCAE: E12308 a hypoalbuminemia AE that requires NCI<LLN - 3 g/dL; <LLN - 30 g/L YH, MW Grade 1 hypoalbuminemia AE CTCAE: E12311 a hypoalbuminemia AE that requires NCI<3 - 2 g/dL; <30 - 20 g/L YH, MW Grade 2 hypoalbuminemia AE CTCAE: E12312 a hypoalbuminemia AE that requires NCI<2 g/dL; <20 g/L YH, MW Grade 3 hypoalbuminemia AE CTCAE: E12313 a hypocalcemia AE that requires corrected serum calcium of <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium <LLN - 1.0 mmol/L YH, MW Grade 1 hypocalcemia AE CTCAE: E12317 a hypocalcemia AE that requires corrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium <1.0 - 0.9 mmol/L; symptomatic YH, MW Grade 2 hypocalcemia AE CTCAE: E12318 a hypocalcemia AE that requires corrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L; Ionized calcium <0.9 - 0.8 mmol/L; hospitalization indicated YH, MW Grade 3 hypocalcemia AE CTCAE: E12319 a hypocalcemia AE that requires corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences YH, MW Grade 4 hypocalcemia AE CTCAE: E12320 a hypoglycernia AE that requires <LLN - 55 mg/dL; <LLN - 3.0 mmol/L YH, MW Grade 1 hypoglycemia AE CTCAE: E12323 a hypoglycernia AE that requires <55 - 40 mg/dL; <3.0 - 2.2 mmol/L YH, MW Grade 2 hypoglycemia AE CTCAE: E13874 a hypoglycernia AE that requires <40 - 30 mg/dL; <2.2 - 1.7 mmol/L YH, MW Grade 3 hypoglycemia AE CTCAE: E12324 a hypoglycernia AE that requires <30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures YH, MW Grade 4 hypoglycemia AE CTCAE: E12325 a hypomagnesemia AE that requires <LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L YH, MW Grade 1 hypomagnesemia AE CTCAE: E12334 a hypomagnesemia AE that requires <1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L YH, MW Grade 2 hypomagnesemia AE CTCAE: E12335 a hypomagnesemia AE that requires <0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L YH, MW Grade 3 hypomagnesemia AE CTCAE: E12336 a hypomagnesemia AE that requires <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences YH, MW Grade 4 hypomagnesemia AE CTCAE: E12337 a hypophosphatemia AE that requires <LLN - 2.5 mg/dL; <LLN - 0.8 mmol/L YH, MW Grade 1 hypophosphatemia AE CTCAE: E12345 a hypophosphatemia AE that requires <2.5 - 2.0 mg/dL; <0.8 - 0.6 mmol/L YH, MW Grade 2 hypophosphatemia AE CTCAE: E12346 a hypophosphatemia AE that requires <2.0 - 1.0 mg/dL; <0.6 - 0.3 mmol/L YH, MW Grade 3 hypophosphatemia AE CTCAE: E12347 a hypophosphatemia AE that requires <1.0 mg/dL; <0.3 mmol/L; life-threatening consequences YH, MW Grade 4 hypophosphatemia AE CTCAE: E12348 YH, JX a behavioral quality where the behavior in an organism is abnormal. WEB: https://en.wikipedia.org/wiki/Abnormality_(behavior) behavior abnormal quality a cough AE that shows an increased rate of coughing YH, JX WEB: http://medical-dictionary.thefreedictionary.com/cough 10011228 cough increased AE a viral infection AE that is caused by a herpes virus. Note that there are 8 herpesvirus types. YH, JX WEB: https://en.wikipedia.org/wiki/Herpesviridae 10019972 herpes viral infection AE a herpez zoster AE that occurs in children. YH, JX WEB: https://en.wikipedia.org/wiki/Varicella_zoster_virus chickenpox AE a nervous system AE that shows abnormal neurologic reflexes, which can be tesetd by the knee jerk reaction. JX, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423 10038254 abnormal reflex AE an abnormal reflex AE where the patient has a condition of below normal or absent reflexes (areflexia). Hyporeflexia is the condition of below normal or absent reflexes. Hyporeflexia is generally associated with a lower motor neuron deficit (at the alpha motor neurons from the spinal cord to muscle). SS, JX, YH reflexes decreased AE WEB: http://en.wikipedia.org/wiki/Hyporeflexia WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423 10021089 hyporeflexia AE HPO: HP_0009072 SIDER: C0151888 an abnormal reflex AE that has an outcome of overactive reflexes, indicative of upper motor neuron disease as well as lessening or loss of control ordinarily exerted by higher brain centers of lower neural pathways. JX, YH WEB: https://en.wikipedia.org/wiki/Hyperreflexia 10020745 hyperreflexia AE HPO: HP_0001347 SIDER: C0151889 a cardiac arrest AE where there is no discernible electrical activity on the ECG monitor. YH, MW asystole WEB: http://www.cardiachealth.org/asystole-and-pulseless-electrical-activity 10003586 Asystole is the absence of electrical activity in the heart, as evidenced by a flat line on an EKG. Cardiac arrest is a more general term for conditions where the heart is not circulating blood. Ventricular fibrillation (V-fib) or pulseless Ventricular tachycardia (V-tach) are examples of EKG rhythms which also will produce cardiac arrest, but are not asystole. Pulseless electrical activity (PEA) is another catch-all where there is an otherwise survivable EKG, but no blood is circulating. This can be caused by trauma to the heart, or tremendous blood loss, among other reasons. See: https://answers.yahoo.com/question/index?qid=20081027100243AAy0yt4 asystole AE CTCAE: E10077 NCit:C50479 an eye inflammation AE that occurs at the corneal area. MW, YH WEB: http://www.mayoclinic.org/diseases-conditions/keratitis/basics/definition/con-20035288 10023332 keratitis AE CTCAE: E10397 NCIT: C26805 an infection AE where one or two eyes get infected by bacteria, fungi, or viruses. MW, YH WEB: https://www.nlm.nih.gov/medlineplus/eyeinfections.html 10015929 eye infection AE CTCAE: E11391 NCIT: C45372 an inflammation AE that shows inflammation at the location of appendix. MW, YH 10003011 appendicitis AE CTCAE: E11292 NCIt: C35145 an electrocardiogram QT prolonged AE that estimates the QT interval at a heart rate of 60 bpm. MW, YH WEB: http://lifeinthefastlane.com/ecg-library/basics/qt_interval/ 10014383 electrocardiogram QT corrected interval prolonged AE CTCAE: E12146 NCIt: C71034 UMLS: C0855333 a cross product of coordination abnormal AE and balance disorder AE YH, QL coordination and balance disturbance AE 10072984 coordination and balance disorder AE an anorexia AE that has loss of appetite of greasy food. QL, YH WEB: http://www.anxietycare.org.uk/docs/eating.asp aversion to greasy food AE a coordination and balance disorder AE that has difficulty in standing YH, QL dystasia AE WEB: http://medical-dictionary.thefreedictionary.com/dysstasia 10050218 dysstasia AE a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation MW, YH WEB: http://www.dermnetnz.org/reactions/radiation-dermatitis.html 10061103 dermatitis radiation AE CTCAE: E11675 NCIt: C0034561 a gastric disorder AE that shows an rupture in the stomach QL, YH stomach rupture WEB: http://medical-dictionary.thefreedictionary.com/gastrorrhexis gastrorrhexis AE an injury AE that refers to break or burst suddenly (esp. of a pipe, a vessel, or a bodily part such as an organ or membrane) YH. QL WEB: https://en.wikipedia.org/wiki/Rupture rupture AE a radiation skin injury AE that shows skin burn from exposure to a large external dose of radiation MW, YH WEB: https://en.wikipedia.org/wiki/Radiation_burn 10063640 radiation burn AE a troponin AE which indicates increased levels of cardiac troponin I in a biological specimen MW, YH 10007612 cardiac troponin I increased AE CTCAE: E12116 NCIt: C78230 a musculoskeletal or connective tissue AE that has greater growth than expected for age. MW, YH 10018746 growth accelerated AE CTCAE: E10317 NCIt: C83495 a surgery AE that has the finding of a previously undocumented problem that occurs after a thoracic procedure. MW, YH 10056745 postoperative thoracic procedure complication AE CTCAE: E11909 NCIt: C78567 a uterine AE that has a rupture in the uterine wall. MW, YH 10046810 uterine perforation AE CTCAE: E12028 NCIt: C50793 a female reproductive system AE that has the finding of rupture of the fallopian tube wall. MW, YH 10065790 fallopian tube perforation AE CTCAE: E11697 NCIt: C78294 an endocrine system AE that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency. MW, YH 10001367 adrenal insufficiency AE CTCAE: E10298 NCIt: C26691 an endocrine system AE that has signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids. MW, YH 10011655 cushingoid AE CTCAE: E10304 NCIt: C37938 an endocrine system AE that has unusually late sexual maturity. MW, YH 10012205 delayed puberty AE CTCAE: E10308 NCIt: C62587 an endocrine system AE that has an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood). MW, YH 10020705 hyperparathyroidism AE CTCAE: E10319 NCIt: C48259 an endocrine system AE that has a decrease in production of parathyroid hormone by the parathyroid glands. MW, YH 10021041 hypoparathyroidism AE CTCAE: E10328 NCIt: C78350 an endocrine system AE that has inappropriate masculinization occurring in a female or prepubertal male. MW, YH 10047488 virilization AE CTCAE: E10343 NCIt: C79859 an endocrine system AE that has unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys. MW, YH 10058084 precocious puberty AE CTCAE: E10340 NCIt: C79704 a medical intervention site AE that has the finding of tumor-like collection of serum in the tissues. MW, YH 10040102 seroma AE CTCAE: E11938 NCIt: C50739 a medical intervention site AE that has a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure. MW, YH 10042127 stomal ulcer AE CTCAE: E11965 NCIt: C79766 a medical intervention site AE that has a finding of blood leakage from the intestinal stoma. MW, YH 10049468 intestinal stoma site bleeding AE CTCAE: E11764 NCIt: C78371 a medical intervention site AE that has the finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures). MW, YH 10050457 pancreatic anastomotic leak AE CTCAE: E11891 NCIt: C78518 a medical intervention site AE that has the finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures). MW, YH 10050458 biliary anastomotic leak AE CTCAE: E11654 NCIt: C78183 a medical intervention site AE that has the finding of blockage of the normal flow of the contents of the intestinal stoma. MW, YH 10059094 intestinal stoma leak AE CTCAE: E11759 NCIt: C78370 a medical intervention site AE that has the finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body). MW, YH 10059095 intestinal stoma leak AE CTCAE: E11753 NCIt: C78369 a medical intervention site AE that has the finding of a previously undocumented problem related to the vascular access site. MW, YH 10062169 vascular access complication AE CTCAE: E12046 NCIt: C78709 a medical intervention site AE that has the finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065705 pharyngeal anastomotic leak AE CTCAE: E11897 NCIt: C78550 a medical intervention site AE that has the finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface. MW, YH 10065745 prolapse of intestinal stoma AE CTCAE: E11914 NCIt: C78570 a medical intervention site AE that has the finding of bleeding from the urostomy site. MW, YH 10065748 urostomy site bleeding AE CTCAE: E12011 NCIt: C78682 a medical intervention site AE that has the finding of blood leakage from the tracheostomy site. MW, YH 10065749 tracheostomy site bleeding AE CTCAE: E11981 NCIt: C78648 a medical intervention site AE that has the finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065788 fallopian tube anastomotic leak AE CTCAE: E11691 NCIt: C78292 a medical intervention site AE that has the finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065802 bladder anastomotic leak AE CTCAE: E11660 NCIt: C78206 a medical intervention site AE that has the finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065803 kidney anastomotic leak AE CTCAE: E11879 NCIt: C78406 a medical intervention site AE that has the finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065814 ureteric anastomotic leak AE CTCAE: E11987 NCIt: C78662 a medical intervention site AE that has the finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065815 urethral anastomotic leak CTCAE: E11993 NCIt: C78667 a medical intervention site AE that has the finding of displacement of the urostomay MW, YH 10065822 prolapse of urostomy AE CTCAE: E11920 NCIt: C78571 a medical intervention site AE that has the finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065879 gastrointestinal anastomotic leak CTCAE: E11715 NCIt: C78318 a medical intervention site AE that has the finding of leakage of contents from a urostomy. MW, YH 10065882 urostomy leak AE CTCAE: E11999 NCIt: C78679 a medical intervention site AE that has the finding of blockage of the urostomy. MW, YH 10065883 urostomy obstruction AE CTCAE: E12005 NCIt: C78680 a medical intervention site AE that has the finding of narrowing of the opening of a urostomy. MW, YH 10065885 urostomy stenosis AE CTCAE: E12017 NCIt: C78683 a medical intervention site AE that has the finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065886 uterine anastomotic leak AE CTCAE: E12022 NCIt: C78684 a medical intervention site AE that has the finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065887 vaginal anastomotic leak AE CTCAE: E12034 NCIt: C78698 a medical intervention site AE that has the finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065888 vas deferens anastomotic leak AE CTCAE: E12040 NCIt: C78704 a medical intervention site AE that has the finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine. MW, YH 10065891 large intestinal anastomotic leak AE CTCAE: E11885 NCIt: C78408 a medical intervention site AE that has the finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel. MW, YH 10065892 small intestinal anastomotic leak AE CTCAE: E11942 NCIt: C78612 a medical intervention site AE that has the finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065893 gastric anastomotic leak AE CTCAE: E11709 NCIt: C78310 a medical intervention site AE that has the finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065894 rectal anastomotic leak AE CTCAE: E11932 NCIt: C78583 a medical intervention site AE that has the finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065897 spermatic cord anastomotic leak AE CTCAE: E11948 NCIt: C78622 a medical intervention site AE that has the finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body). MW, YH 10065898 stenosis of gastrointestinal stoma AE CTCAE: E11960 NCIt: C78628 a medical intervention site AE that has the finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures). MW, YH 10065961 esophageal anastomotic leak AE CTCAE: E11681 NCIt: C78270 an infection AE that has an infectious process involving the bladder. MW, YH 10005047 bladder infection AE CTCAE: E11309 NCIt: C26738 an infection AE that has an infectious process involving the uterine cervix. MW, YH 10008330 cervicitis infection AE CTCAE: E11337 NCIt: C78360 an infection AE that has an infectious process involving the brain tissue. MW, YH 10014594 encephalitis infection AE CTCAE: E11365 NCIt: C79550 an infection AE that has an infectious process involving the brain and spinal cord tissues. MW, YH 10014621 encephalomyelitis infection AE CTCAE: E11369 NCIt: C79551 an infection AE that has an infectious process involving the endocardial layer of the heart. MW, YH 10014678 endocarditis infective AE CTCAE: E11373 NCIt: C78265 an infection AE that has an infectious process involving the gums. MW, YH 10018784 gum infection AE CTCAE: E11400 NCIt: C78329 an infection AE that has an infectious process involving the skeletal muscles. MW, YH 10021918 infective myositis AE CTCAE: E11421 NCIt: C26984 an infection AE that has an infectious process involving a joint. MW, YH 10023216 joint infection AE CTCAE: E11426 NCIt: C78402 an infection AE that has an infectious process involving the kidney. MW, YH 10023424 kidney infection AE CTCAE: E11431 NCIt: C34965 an infection AE that has an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage. MW, YH 10033072 otitis externa AE CTCAE: E11472 NCIt: C3299 an infection AE that has an infectious process involving the salivary gland. MW, YH 10039413 salivary gland infection AE CTCAE: E11550 NCIt: C78601 an infection AE that has an infectious process involving the wound. MW, YH 10048038 wound infection AE CTCAE: E11635 NCIt: C45234 an infection AE that has an infectious process involving a tooth. MW, YH 10048762 tooth infection AE CTCAE: E11594 NCIt: C78639 an infection AE that has an infectious process involving the prostate gland. MW, YH 10050662 prostate infection AE CTCAE: E11540 NCIt: C27615 an infection AE that has an infectious process involving the lymph nodes. MW, YH 10050823 lymph gland infection AE CTCAE: E11449 NCIt: C26821 an infection AE that has an infectious process involving the pancreas. MW, YH 10051741 pancreas infection AE CTCAE: E11487 NCIt: C78517 an infection AE that has an infectious process involving the urethra. MW, YH 10052298 urethral infection AE CTCAE: E11609 NCIt: C78671 an infection AE that has an infectious process involving the ovary. MW, YH 10055005 ovarian infection AE CTCAE: E11482 NCIt: C78512 an infection AE that has an infectious process involving the abdominal cavity. MW, YH 10056519 abdominal infection AE CTCAE: E11282 NCIt: C35669 an infection AE that has an infectious process involving the liver. MW, YH 10056522 hepatic infection AE CTCAE: E11406 NCIt: C78339 an infection AE that has an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein. MW, YH 10056627 phlebitis infective AE CTCAE: E11530 NCIt: C78558 an infection AE that has an infectious process involving the peritoneum. MW, YH 10057262 peritoneal infection AE CTCAE: E11521 NCIt: C78540 an infection AE that has an infectious process involving the mediastinum. MW, YH 10057483 mediastinal infection AE CTCAE: E11454 NCIt: C26827 an infection AE that has an infectious process involving the pelvic cavity. MW, YH 10058674 pelvic infection AE CTCAE: E11501 NCIt: C3889 an infection AE that has an infectious process involving the esophagus. MW, YH 10058804 esophageal infection AE CTCAE: E11386 NCIt: C78277 an infection AE that has an infectious process involving the small and large intestines. MW, YH 10058838 enterocolitis infectious AE CTCAE: E11381 NCIt: C80513 an infection AE that has an infectious process involving the nasal mucosal. MW, YH 10059827 rhinitis infective AE CTCAE: E11548 NCIt: C78599 an infection AE that has an infectious process involving the bones. MW, YH 10061017 bone infection AE CTCAE: E11314 NCIt: C26839 an infection AE that has an infectious process involving the pleura. MW, YH 10061351 pleural infection AE CTCAE: E11535 NCIt: C78563 an infection AE that has an infectious process involving the anal area and the rectum. MW, YH 10061640 anorectal infection AE CTCAE: E11286 NCIt: C78174 an infection AE that has an infectious process involving the biliary tract. MW, YH 10061695 biliary tract infection AE CTCAE: E11305 NCIt: C26718 an infection AE that has an infectious process involving the penis. MW, YH 10061912 penile infection AE CTCAE: E11506 NCIt: C78526 an infection AE that has an infectious process involving the spleen. MW, YH 10062112 splenic infection AE CTCAE: E11584 NCIt: C78627 an infection AE that has an infectious process involving the scrotum. MW, YH 10062156 scrotal infection AE CTCAE: E11555 NCIt: C78606 an infection AE that has an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues. MW, YH 10062233 uterine infection AE CTCAE: E11619 NCIt: C26764 an infection AE that has an infectious process involving the gallbladder. MW, YH 10062632 gallbladder infection AE CTCAE: E11396 NCIt: C78306 an infection AE that has an infectious process involving a stoma (surgically created opening on the surface of the body). MW, YH 10064505 stoma site infection AE CTCAE: E11588 NCIt: C78629 an infection AE that has an infectious process involving an artery. MW, YH 10065744 arteritis infective AE CTCAE: E11301 NCIt: C34399 an infection AE that has an infectious process involving the duodenum. MW, YH 10065752 duodenal infection AE CTCAE: E11360 NCIt: C78258 an infection AE that has an infectious process involving the lips. MW, YH 10065755 lip infection AE CTCAE: E11440 NCIt: C78434 an infection AE that has an infectious process involving the cecum. MW, YH 10065761 cecal infection AE CTCAE: E11333 NCIt: C78235 an infection AE that has an infectious process involving a mucosal surface. MW, YH 10065764 mucosal infection AE CTCAE: E11462 NCIt: C78454 an infection AE that has an infectious process involving a cranial nerve. MW, YH 10065765 cranial nerve infection AE CTCAE: E11352 NCIt: C78248 an infection AE that has an infectious process involving the peripheral nerves. MW, YH 10065766 peripheral nerve infection AE CTCAE: E11516 NCIt: C27589 an infection AE that has an infectious process involving the small intestine. MW, YH 10065771 small intestine infection AE CTCAE: E11574 NCIt: C78618 an infection AE that has an infectious process involving the vulva. MW, YH 10065772 vulval infection AE CTCAE: E11629 NCIt: C78716 a pain AE that has a sensation of marked discomfort in the anal region. MW, YH 10002167 anal pain AE CTCAE: E10486 NCIt: C78172 a pain AE that has a sensation of marked discomfort in the gallbladder region. MW, YH 10017638 gallbladder pain AE CTCAE: E11204 NCIt: C78304 a pain AE that has a sensation of marked discomfort in the gastrointestinal region. MW, YH 10017999 gastrointestinal pain AE CTCAE: E10755 NCIt: C78320 a pain AE that has a sensation of marked discomfort in the liver region. MW, YH 10019705 hepatic pain AE CTCAE: E11224 NCIt: C78341 a pain AE that has a sensation of marked discomfort of the lip. MW, YH 10024561 lip pain AE CTCAE: E10857 NCIt: C79684 a pain AE that has a sensation of marked discomfort in the rectal region. MW, YH 10038072 rectal pain AE CTCAE: E10977 NCIt: C78587 a pain AE that has a sensation of marked discomfort in the stomach. MW, YH 10042112 stomach pain AE CTCAE: E11044 NCIt: C78630 a chest pain AE that has discomfort in the chest unrelated to a heart disorder. MW, YH 10062501 non-cardiac chest pain AE CTCAE: E11163 NCIt: C78504 a respiratory system AE that has the finding of blockage of the lumen of the trachea. MW, YH 10044291 tracheal obstruction AE CTCAE: E11975 NCIt: C78645 a hemorrhage AE that has bleeding from the colon. MW, YH 10009998 colonic hemorrhage AE CTCAE: E10533 NCIt: C78240 a hemorrhage AE that has bleeding from the esophagus. MW, YH 10015384 esophageal hemorrhage AE CTCAE: E10645 NCIt: C78271 a hemorrhage AE that has bleeding from esophageal varices. MW, YH 10015453 esophageal varices hemorrhage AE CTCAE: E10682 NCIt: C78282 a hemorrhage AE that has bleeding from the liver. MW, YH 10019678 hepatic hemorrhage AE CTCAE: E11215 NCIt: C78338 a hemorrhage AE that has bleeding from the mouth. MW, YH 10030980 oral hemorrhage AE CTCAE: E10898 NCIt: C79699 a hemorrhage AE that has bleeding from the pancreas. MW, YH 10033626 pancreatic hemorrhage AE CTCAE: E10920 NCIt: C78521 a hemorrhage AE that has bleeding from the retroperitoneal area. MW, YH 10038981 retroperitoneal hemorrhage AE CTCAE: E10998 NCIt: C26944 a hemorrhage AE that has bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus). MW, YH 10051746 lower gastrointestinal hemorrhage AE CTCAE: E10861 NCIt: C78438 a hemorrhage AE that has bleeding from the duodenum. MW, YH 10055242 duodenal hemorrhage AE CTCAE: E10588 NCIt: C78257 a hemorrhage AE that has bleeding from the ileal wall. MW, YH 10055287 ileal hemorrhage AE CTCAE: E10783 NCIt: C78353 a hemorrhage AE that has bleeding in the abdominal cavity. MW, YH 10055291 intra-abdominal hemorrhage AE CTCAE: E10817 NCIt: C78372 a hemorrhage AE that has bleeding from the jejunal wall. MW, YH 10055300 jejunal hemorrhage AE CTCAE: E10828 NCIt: C78397 a hemorrhage AE that has the finding of bleeding occurring after a surgical procedure. MW, YH 10055322 postoperative hemorrhage AE CTCAE: E11903 NCIt: C34938 a hemorrhage AE that has the finding of bleeding from the trachea. MW, YH 10062548 tracheal hemorrhage AE CTCAE: E11969 NCIt: C78642 a hemorrhage AE that has bleeding from the cecum. MW, YH 10065747 cecal hemorrhage AE CTCAE: E10511 NCIt: C78234 an anus AE that has a narrowing of the lumen of the anal canal. MW, YH 10002176 anal stenosis AE CTCAE: E10490 NCIt: C78173 a digestive system AE that has an abnormal communication between the bile ducts and another organ or anatomic site. MW, YH 10004665 biliary fistula AE CTCAE: E11179 NCIt: C79540 a digestive system AE that has subject-reported feeling of uncomfortable fullness of the abdomen. MW, YH 10005265 bloating AE CTCAE: E10508 NCIt: C78213 a digestive system AE that has an abnormal communication between the large intestine and another organ or anatomic site. MW, YH 10009995 colonic fistula AE CTCAE: E10527 NCIt: C78239 a digestive system AE that has blockage of the normal flow of the intestinal contents in the colon. MW, YH 10010000 colonic obstruction AE CTCAE: E10539 NCIt: C78241 a digestive system AE that has a rupture in the colonic wall. MW, YH 10010001 colonic perforation AE CTCAE: E10545 NCIt: C78242 a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon. MW, YH 10010006 colonic ulcer AE CTCAE: E10556 NCIt: C78244 a duodenum AE that has an abnormal communication between the duodenum and another organ or anatomic site. MW, YH 10013828 duodenal fistula AE CTCAE: E10582 NCIt: C78256 a duodenum AE that has blockage of the normal flow of stomach contents through the duodenum. MW, YH 10013830 duodenal obstruction AE CTCAE: E10594 NCIt: C79548 a duodenum AE that has a rupture in the duodenal wall. MW, YH 10013832 duodenal perforation AE CTCAE: E10600 NCIt: C78259 an esophagus AE that has blockage of the normal flow of the contents in the esophagus. MW, YH 10015387 esophageal obstruction AE CTCAE: E10655 NCIt: C78279 an esophagus AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall. MW, YH 10015451 esophageal ulcer AE CTCAE: E10676 NCIt: C26950 a digestive system AE that has an abnormal communication between the gallbladder and another organ or anatomic site. MW, YH 10017631 gallbladder fistula AE CTCAE: E11189 NCIt: C78305 a digestive system AE that has blockage of the normal flow of the contents of the gallbladder. MW, YH 10017636 gallbladder obstruction AE CTCAE: E11198 NCIt: C78308 a gastrointestinal perforation AE that occurs in the stomach wall. MW, YH 10017815 gastric perforation AE CTCAE: E10716 NCIt: C78316 a gastrointestinal disoder AE that has an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site. MW, YH 10017877 gastrointestinal fistula AE CTCAE: E10749 NCIt: C78319 a gastric AE that has an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine. MW, YH 10018043 gastroparesis AE CTCAE: E10759 NCIt: C80512 a digestive system AE that has a narrowing of the lumen of the ileum. MW, YH 10021307 ileal stenosis AE CTCAE: E10800 NCIt: C78356 a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum. MW, YH 10021309 ileal ulcer AE CTCAE: E10806 NCIt: C78357 a digestive system AE that has a rupture in the jejunal wall. MW, YH 10023174 jejunal perforation AE CTCAE: E10840 NCIt: C78399 a digestive system AE that has a narrowing of the lumen of the jejunum. MW, YH 10023176 jejunal stenosis AE CTCAE: E10845 NCIt: C78400 a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum. MW, YH 10023177 jejunal ulcer AE CTCAE: E10851 NCIt: C78401 a digestive system AE that has inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea. MW, YH 10025476 malabsorption AE CTCAE: E10867 NCIt: C3214 a digestive system AE that has blockage of the normal flow of the contents in the stomach. MW, YH 10029957 obstruction gastric AE CTCAE: E10882 NCIt: C78505 a digestive system AE that has a rupture in the wall of the extrahepatic or intrahepatic bile duct. MW, YH 10034405 perforation bile duct AE CTCAE: E11234 NCIt: C78528 a digestive system AE that has an abnormal communication between the rectum and another organ or anatomic site. MW, YH 10038062 rectal fistula AE CTCAE: E10949 NCIt: C79713 a digestive system AE that has a rupture in the rectal wall. MW, YH 10038073 rectal perforation AE CTCAE: E10981 NCIt: C78588 a digestive system AE that has a narrowing of the lumen of the rectum. MW, YH 10038079 rectal stenosis AE CTCAE: E10986 NCIt: C78589 a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum. MW, YH 10038080 rectal ulcer AE CTCAE: E10992 NCIt: C78590 a digestive system AE that has an abnormal communication between a salivary gland and another organ or anatomic site. MW, YH 10039411 salivary gland fistula AE CTCAE: E11009 NCIt: C79715 a digestive system AE that has a rupture in the small intestine wall. MW, YH 10041103 small intestinal perforation AE CTCAE: E11027 NCIt: C78616 a digestive system AE that has an abnormal communication between the pancreas and another organ or anatomic site. MW, YH 10049192 pancreatic fistula AE CTCAE: E10914 NCIt: C79701 a duodenum AE that has a narrowing of the lumen of the duodenum. MW, YH 10050094 duodenal stenosis AE CTCAE: E10605 NCIt: C78260 a digestive system AE that has a narrowing of the lumen of the bile duct. MW, YH 10051341 bile duct stenosis AE CTCAE: E11173 NCIt: C78182 a gastric disorder AE that has a necrotic process occurring in the gastric wall. MW, YH 10051886 gastric necrosis AE CTCAE: E10712 NCIt: C78314 a digestive system AE that has a necrotic process occurring in the pancreas. MW, YH 10058096 pancreatic necrosis AE CTCAE: E10926 NCIt: C78522 a digestive system AE that has a necrotic process occurring in the gallbladder. MW, YH 10059446 gallbladder necrosis AE CTCAE: E11195 NCIt: C78307 a gastric disorder AE that has a narrowing of the lumen of the stomach. MW, YH 10061970 gastric stenosis AE CTCAE: E10721 NCIt: C78317 a digestive system AE that has an abnormal communication between the urinary bladder and the intestine. MW, YH 10062570 enterovesical fistula AE CTCAE: E10633 NCIt: C78266 a digestive system AE that has a narrowing of the lumen of the pancreatic duct. MW, YH 10065703 pancreatic duct stenosis AE CTCAE: E10908 NCIt: C78519 a digestive system AE that has a necrotic process occurring in the peritoneum. MW, YH 10065704 peritoneal necrosis AE CTCAE: E10939 NCIt: C78543 a digestive system AE that has blockage of the normal flow of the intestinal contents in the rectum. MW, YH 10065707 rectal obstruction AE CTCAE: E10971 NCIt: C78586 a gastrointestinal disoder AE that has the finding of a necrotic process occurring in the gastrointestinal tract stoma. MW, YH 10065712 gastrointestinal stoma necrosis CTCAE: E11721 NCIt: C78321 a gastric disorder AE that has an abnormal communication between the stomach and another organ or anatomic site. MW, YH 10065713 gastric fistula AE CTCAE: E10700 NCIt: C79595 a digestive system AE that has an abnormal communication between the jejunum and another organ or anatomic site. MW, YH 10065719 jejunal fistula AE CTCAE: E10822 NCIt: C78396 an anus AE that has a necrotic process occurring in the anal region. MW, YH 10065722 anal necrosis AE CTCAE: E10482 NCIt: C78171 an esophagus AE that has a necrotic process occurring in the esophageal wall. MW, YH 10065727 esophageal necrosis AE CTCAE: E10651 NCIt: C78278 a digestive system AE that has an abnormal communication between the ileum and another organ or anatomic site. MW, YH 10065728 ileal fistula AE CTCAE: E10777 NCIt: C78352 a digestive system AE that has blockage of the normal flow of the intestinal contents in the ileum. MW, YH 10065730 ileal obstruction AE CTCAE: E10789 NCIt: C78354 a digestive system AE that has blockage of the normal flow of the intestinal contents in the jejunum. MW, YH 10065732 jejunal obstruction AE CTCAE: E10834 NCIt: C78398 an esophagus AE that has an abnormal communication between the esophagus and another organ or anatomic site. MW, YH 10065851 esophageal fistula AE CTCAE: E10639 NCIt: C79574 an eye AE that has dryness of the cornea and conjunctiva. MW, YH 10013774 dry eye AE CTCAE: E10363 NCIt: C34553 an eye AE that has a sudden or brief burst of light. MW, YH 10016757 flashing lights AE CTCAE: E10384 NCIt: C50568 an eye AE that has an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens. MW, YH 10016778 floaters AE CTCAE: E10388 NCIt: C37955 an eye AE that has an inability to see clearly in dim light. MW, YH 10029404 night blindness AE CTCAE: E10401 NCIt: C34850 an eye AE that has a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters. MW, YH 10038897 retinal tear AE CTCAE: E10425 NCIt: C50732 an eye AE that has pathological retinal blood vessels that adversely affects vision. MW, YH 10038901 retinal vascular disorder AE CTCAE: E10429 NCIt: C35170 an eye AE that has blood extravasation into the vitreous humor. MW, YH 10047656 vitreous hemorrhage AE CTCAE: E10447 NCIt: C50469 an eye AE that has excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct. MW, YH 10047848 watering eyes AE CTCAE: E10452 NCIt: C78717 an eye AE that has involvement of the optic nerve (second cranial nerve). MW, YH 10061322 optic nerve disorder AE CTCAE: E10406 NCIt: C79698 an eye AE that has involvement of the sclera of the eye. MW, YH 10061510 scleral disorder AE CTCAE: E10437 NCIt: C79717 an ear AE that has dizziness, imbalance, nausea, and vision problems. MW, YH 10047386 vestibular disorder AE CTCAE: E10295 NCIt: C27166 an ear pain AE that has a sensation of marked discomfort in the external ear region. MW, YH 10065785 external ear pain AE CTCAE: E10272 NCIt: C78285 a cardiovascular AE that has a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action. MW, YH 10010783 constrictive pericarditis AE CTCAE: E10120 NCIt: C78246 a cardiovascular AE that has a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness. MW, YH 10040639 sick sinus syndrome AE CTCAE: E10202 NCIt: C62244 a cardiovascular AE that has an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium. MW, YH 10053565 pericardial tamponade AE CTCAE: E10177 NCIt: C50481 a cardiovascular AE that has a defect in tricuspid valve function or structure. MW, YH 10061389 tricuspid valve disease AE CTCAE: E10224 NCIt: C78649 a cardiovascular AE that has a defect in mitral valve function or structure. MW, YH 10061532 mitral valve disease AE CTCAE: E10134 NCIt: C78446 a cardiovascular AE that has a defect in pulmonary valve function or structure. MW, YH 10061541 pulmonary valve disease AE CTCAE: E10186 NCIt: C78579 a cardiovascular AE that has a defect in aortic valve function or structure. MW, YH 10061589 aortic valve disease AE CTCAE: E10071 NCIt: C78650 a bone AE that has a change in tooth hue or tint. MW, YH 10044031 tooth discoloration AE CTCAE: E11052 NCIt: C80112 an edema AE that has swelling due to an accumulation of excessive fluid in the neck. MW, YH 10054482 neck edema AE CTCAE: E11159 NCIt: C78501 an edema AE that has swelling due to excessive fluid accumulation in the trunk area. MW, YH 10058720 edema trunk AE CTCAE: E11090 NCIt: C78263 an inflammation AE that has inflammation of the rectum. MW, YH 10036774 proctitis AE CTCAE: E10943 NCIt: C38011 an inflammation AE that has inflammation of the mucous membrane of the rectum MW, YH 10063190 rectal mucositis AE CTCAE: E10961 NCIt: C78584 an inflammation AE that has inflammation of the mucous membrane of the anus. MW, YH 10065721 anal mucositis AE CTCAE: E10476 NCIt: C78170 an inflammation AE that has inflammation, swelling and redness to the outer ear and ear canal. MW, YH 10065837 external ear inflammation AE CTCAE: E10266 NCIt: C79601 an inflammation AE that has inflammation (physiologic response to irritation), swelling and redness to the middle ear. MW, YH 10065838 middle ear inflammation AE CTCAE: E10281 NCIt: C34885 a death AE that has cessation of life occurring during the first 28 days of life. MW, YH 10011912 death neonatal AE CTCAE: E11078 NCIt: C80082 a fracture AE that has a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot. MW, YH 10002544 ankle fracture AE CTCAE: E11640 NCIt: C26989 a fracture AE that has the finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. MW, YH 10020100 hip fracture AE CTCAE: E11726 NCIt: C26794 a fracture AE that has the finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken. MW, YH 10041569 spinal fracture AE CTCAE: E11954 NCIt: C80516 a fracture AE that has the finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. MW, YH 10048049 wrist fracture AE CTCAE: E12069 NCIt: C80517 a lung infection AE that has an infectious process involving the bronchi. MW, YH 10055078 bronchial infection AE CTCAE: E11323 NCIt: C2911 a muscle enzyme level increased AE that has the finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen. MW, YH 10011268 CPK increased AE CTCAE: E12132 NCIt: C78247 a recall phenomenon AE that has the finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent. MW, YH 10037767 radiation recall reaction (dermatologic) AE CTCAE: E11926 NCIt: C78580 an immunology and allergy investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen. MW, YH 10007839 CD4 lymphocytes decreased AE CTCAE: E12122 NCIt: C78233 a respiratory and pulmonary investigation result abnormal AE that has the finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value. MW, YH 10047580 vital capacity abnormal AE CTCAE: E12220 NCIt: C78715 a respiratory and pulmonary investigation result abnormal AE that has the finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide. MW, YH 10065906 carbon monoxide diffusing capacity decreased AE CTCAE: E12112 NCIt: C78229 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen. MW, YH 10005332 blood antidiuretic hormone abnormal AE CTCAE: E12092 NCIt: C78214 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen. MW, YH 10005452 blood corticotrophin decreased AE CTCAE: E12101 NCIt: C78215 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen. MW, YH 10005561 blood gonadotrophin abnormal AE CTCAE: E12105 NCIt: C78216 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen. MW, YH 10005778 blood prolactin abnormal AE CTCAE: E12109 NCIt: C78217 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen. MW, YH 10018748 growth hormone abnormal AE CTCAE: E12166 NCIt: C78327 an enzyme investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen. MW, YH 10062646 pancreatic enzymes decreased AE CTCAE: E12203 NCIt: C78520 a hematology investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen. MW, YH 10016596 fibrinogen decreased AE CTCAE: E12151 NCIt: C78300 a hematology investigation result abnormal with the finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen. MW, YH 10019150 haptoglobin decreased AE CTCAE: E12169 NCIt: C78330 a coronary heart disease AE that has signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction. MW, YH 10051592 acute coronary syndrome AE CTCAE: E10066 NCIt: C53652 an eyelid disorder AE that has impaired eyelid function. MW, YH 10061145 eyelid function disorder AE CTCAE: E10380 NCIt: C78288 an injury AE that has the finding of damage to the aorta. MW, YH 10002899 aortic injury AE CTCAE: E11644 NCIt: C35623 an injury AE that has the finding of damage to an artery MW, YH 10003162 arterial injury AE CTCAE: E11648 NCIt: C35401 an injury AE that has the finding of damage to the carotid artery. MW, YH 10022161 injury to carotid artery AE CTCAE: E11730 NCIt: C79599 an injury AE that has the finding of damage to the inferior vena cava. MW, YH 10022213 injury to inferior vena cava AE CTCAE: E11734 NCIt: C78363 an injury AE that has the finding of damage to the superior vena cava. MW, YH 10022356 injury to superior vena cava AE CTCAE: E11741 NCIt: C78365 an injury AE that has the finding of damage to the gastrointestinal system during a surgical procedure. MW, YH 10065825 intraoperative gastrointestinal injury AE CTCAE: E11798 NCIt: C78380 an injury AE that has the finding of damage to an artery during a surgical procedure. MW, YH 10065826 intraoperative arterial injury AE CTCAE: E11770 NCIt: C78375 an injury AE that has the finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure. MW, YH 10065827 intraoperative hepatobiliary injury AE CTCAE: E11814 NCIt: C78382 an injury AE that has the finding of damage to the urinary system during a surgical procedure. MW, YH 10065828 intraoperative urinary injury AE CTCAE: E11867 NCIt: C78391 an injury AE that has the finding of damage to the musculoskeletal system during a surgical procedure. MW, YH 10065829 intraoperative musculoskeletal injury AE CTCAE: E11820 NCIt: C78383 an injury AE that has the finding of damage to the nervous system during a surgical procedure. MW, YH 10065830 intraoperative neurological injury AE CTCAE: E11826 NCIt: C78384 an injury AE that has the finding of damage to the breast parenchyma during a surgical procedure. MW, YH 10065831 intraoperative breast injury AE CTCAE: E11776 NCIt: C78376 an injury AE that has the finding of damage to the respiratory system during a surgical procedure. MW, YH 10065832 intraoperative respiratory injury AE CTCAE: E11850 NCIt: C78388 an injury AE that has the finding of damage to the endocrine gland during a surgical procedure. MW, YH 10065834 intraoperative endocrine injury AE CTCAE: E11792 NCIt: C78379 an injury AE that has the finding of damage to the reproductive organs during a surgical procedure. MW, YH 10065840 intraoperative reproductive tract injury AE CTCAE: E11844 NCIt: C78387 an injury AE that has the finding of damage to the eye during a surgical procedure. MW, YH 10065841 intraoperative ocular injury AE CTCAE: E11832 NCIt: C78385 an injury AE that has the finding of damage to the head and neck during a surgical procedure. MW, YH 10065842 lintraoperative head and neck injury AE CTCAE: E11804 NCIt: C78381 an injury AE that has the finding of damage to the heart during a surgical procedure. MW, YH 10065843 intraoperative cardiac injury AE CTCAE: E11782 NCIt: C78377 an injury AE that has the finding of damage to the ear during a surgical procedure. MW, YH 10065844 intraoperative ear injury AE CTCAE: E11786 NCIt: C78378 an injury AE that has the finding of damage to the kidney during a surgical procedure. MW, YH 10065845 intraoperative renal injury AE CTCAE: E11838 NCIt: C78386 an injury AE finding of damage to the skin during a surgical procedure. MW, YH 10065846 intraoperative skin injury AE CTCAE: E11856 NCIt: C78389 an injury AE that has the finding of damage to the spleen during a surgical procedure. MW, YH 10065847 intraoperative splenic injury AE CTCAE: E11862 NCIt: C78390 an injury AE that has the finding of damage to a vein during a surgical procedure. MW, YH 10065848 intraoperative venous injury AE CTCAE: E11873 NCIt: C78392 an injury AE that has the finding of damage to the jugular vein. MW, YH 10065849 injury to jugular vein AE CTCAE: E11737 NCIt: C78364 an appendicitis AE that has acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity. MW, YH 10003012 appendicitis perforated AE CTCAE: E11296 NCIt: C78178 a troponin AE which indicates increased levels of cardiac troponin T in a biological specimen MW, YH 10007613 cardiac troponin T increased CTCAE: E12119 NCIt: C78231 an eye infection AE that has an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes. MW, YH 10010742 conjunctivitis infective AE CTCAE: E11342 NCIt: C35704 an eye infection AE that has an infectious process involving the internal structures of the eye. MW, YH 10014801 endophthalmitis AE CTCAE: E11377 NCIt: C34586 an eye infection AE that has an infectious process involving the orbit of the eye. MW, YH 10051472 periorbital infection AE CTCAE: E11511 NCIt: C78531 an eye infection AE that has an infectious process involving the cornea. MW, YH 10061788 corneal infection AE CTCAE: E11347 NCIt: C26805 a fatigue AE that has fatigue relieved by rest MW, YH Grade 1 fatigue AE CTCAE: E11099 a fatigue AE that has fatigue not relieved by rest; limiting instrumental activities of daily living MW, YH Grade 2 fatigue AE CTCAE: E11100 a fatigue AE that has fatigue not relieved by rest, limiting self care activities of daily living MW, YH Grade 3 fatigue AE CTCAE: E11101 a myocardial infarction AE that has asymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes MW, YH Grade 2 myocardial infarction AE CTCAE: E10153 a myocardial infarction AE that has severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction MW, YH Grade 3 myocardial infarction AE CTCAE: E10154 a pancreatitis AE that has enzyme elevation or radiologic findings only MW, YH Grade 3 pancreatitis AE CTCAE: E10931 a pancreatitis AE that has severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support) MW, YH Grade 3 pancreatitis AE CTCAE: E10932 an activated partial thromboplastin time prolonged AE that is greater than the upper limit of normal to 1.5 times the upper limit of normal MW, YH Grade 1 activated partial thromboplastin time prolonged AE CTCAE: E12074 an activated partial thromboplastin time prolonged AE that is 1.5-2.5 times the upper limit of normal MW, YH Grade 2 activated partial thromboplastin time prolonged AE CTCAE: E12075 an activated partial thromboplastin time prolonged AE that is greater than 2.5 times the upper limit of normal; hemorrhage MW, YH Grade 3 activated partial thromboplastin time prolonged AE CTCAE: E12076 an alanine aminotransferase level increased AE that is greater than the upper limit of normal to 3 times the upper limit of normal MW, YH Grade 1 alanine aminotransferase level increased AE CTCAE: E12078 an alanine aminotransferase level increased AE that is greater than 3 to 5 times the upper limit of normal MW, YH Grade 2 alanine aminotransferase level increased AE CTCAE: E12079 an alanine aminotransferase level increased AE that is greater than 5 to 20 times the upper limit of normal MW, YH Grade 3 alanine aminotransferase level increased AE CTCAE: E12080 an alanine aminotransferase level increased AE that is greater than 20 times the upper limit of normal MW, YH Grade 4 alanine aminotransferase level increased AE CTCAE: E12081 an anal ulcer AE that is symptomatic; altered GI function MW, YH Grade 2 anal ulcer AE CTCAE: E10498 an anal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling MW, YH Grade 3 anal ulcer AE CTCAE: E10499 an atrial flutter AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation MW, YH Grade 3 atrial flutter AE CTCAE: E10090 an otitis media AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 otitis media AE CTCAE: E11478 an otitis media AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 otitis media AE CTCAE: E11479 a pericarditis AE that has asymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis MW, YH Grade 1 pericarditis AE CTCAE: E10181 a pericarditis AE that has symptomatic pericarditis (e.g., chest pain) MW, YH Grade 2 pericarditis AE CTCAE: E10182 a pericarditis AE that has pericarditis with physiologic consequences (e.g., pericardial constriction) MW, YH Grade 3 pericarditis AE CTCAE: E10183 a pharyngitis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 pharyngitis AE CTCAE: E11526 a pharyngitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 pharyngitis AE CTCAE: E11527 a fever AE that has 38.0 - 39.0 degrees C (100.4 - 102.2 degrees F) MW, YH Grade 1 fever AE CTCAE: E11103 a fever AE that has greater than 39.0 - 40.0 degrees C (102.3 - 104.0 degrees F) MW, YH Grade 2 fever AE CTCAE: E11104 a fever AE that has greater than 40.0 degrees C (greater than104.0 degrees F) for less than or equal to 24 hrs MW, YH Grade 3 fever AE CTCAE: E11105 a fever AE that has greater than 40.0 degrees C (greater than104.0 degrees F) for more than 24 hrs MW, YH Grade 4 fever AE CTCAE: E11106 an injection-site adverse event characterized by tenderness with or without associated symptoms (e.g., warmth, erythema, itching) MW, YH Grade 1 injection-site adverse event CTCAE: E11139 an injection-site adverse event characterized by pain; lipodystrophy; edema; phlebitis MW, YH Grade 2 injection-site adverse event CTCAE: E11140 an injection-site adverse event characterized by ulceration or necrosis; severe tissue damage; operative intervention indicated MW, YH Grade 3 injection-site adverse event CTCAE: E11141 a leukocyte cell number increased AE where leukocytes are greater than 100,000/mm3 MW, YH Grade 3 leukocytosis AE CTCAE: E10049 a leukocyte cell number increased AE that has clinical manifestations of leucostasis; urgent intervention indicated MW, YH Grade 4 leukocytosis AE CTCAE: E10050 a leukocyte cell number decreased AE that is less than the lower limit of normal - 3000/mm3; less than the lower limit of normal - 3.0 x 10e9 /L MW, YH Grade 1 leukocyte cell number decreased AE CTCAE: E12233 a leukocyte cell number decreased AE that is less than 3000 - 2000/mm3; less than 3.0 - 2.0 x 10e9 /L MW, YH Grade 2 leukocyte cell number decreased AE CTCAE: E12234 a leukocyte cell number decreased AE that is less than 2000 - 1000/mm3; less than 2.0 - 1.0 x 10e9 /L MW, YH Grade 3 leukocyte cell number decreased AE CTCAE: E12235 a leukocyte cell number decreased AE that is less than 1000/mm3; less than 1.0 x 10e9 /L MW, YH Grade 4 leukocyte cell number decreased AE CTCAE: E12236 a malaise AE that has uneasiness or lack of well being MW, YH Grade 1 malaise AE CTCAE: E11153 a malaise AE that has uneasiness or lack of well being; limiting instrumental activities of daily living MW, YH Grade 2 malaise AE CTCAE: E11154 a chills AE that has mild sensation of cold; shivering; chattering of teeth MW, YH Grade 1 chills AE CTCAE: E11075 A chills AE that has moderate tremor of the entire body; narcotics indicated MW, YH Grade 2 chills AE CTCAE: E11076 a chills AE that has severe or prolonged, not responsive to narcotics MW, YH Grade 3 chills AE CTCAE: E11077 an edema face AE that has localized facial edema MW, YH Grade 1 edema face AE CTCAE: E11083 a meningitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated; focal neurologic deficit MW, YH Grade 3 meningitis AE CTCAE: E11459 a serum sickness AE that has moderate arthralgia; fever, rash, urticaria, antihistamines indicated MW, YH Grade 2 serum sickness AE CTCAE: E11278 a serum sickness AE that has severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated MW, YH Grade 3 serum sickness AE CTCAE: E11279 a urinary tract infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 urinary tract infection AE CTCAE: E11615 a urinary tract infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 urinary tract infection AE CTCAE: E11616 a laryngitis AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 laryngitis AE CTCAE: E11436 a laryngitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 laryngitis AE CTCAE: E11437 a dry mouth AE that is symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow greater than0.2 ml/min MW, YH Grade 1 dry mouth AE CTCAE: E10579 a dry mouth AE that has moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min MW, YH Grade 2 dry mouth AE CTCAE: E10580 a dry mouth AE that has the inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min MW, YH Grade 3 dry mouth AE CTCAE: E10581 a pustular rash AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 pustular rash AE CTCAE: E11546 a pustular rash AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 pustular rash AE CTCAE: E11547 a flatulence AE that has moderate; persistent; psychosocial sequelae MW, YH Grade 2 flatulence AE CTCAE: E10699 a weight loss AE that is 5 to less than 10% from baseline; intervention not indicated MW, YH Grade 1 weight loss AE CTCAE: E12229 a weight loss AE that is 10 - less than 20% from baseline; nutritional support indicated MW, YH Grade 2 weight loss AE CTCAE: E12230 a weight loss AE that is greater than or equal to 20% from baseline; tube feeding or TPN indicated MW, YH Grade 3 weight loss AE CTCAE: E12231 an abnormal gait AE that has mild change in gait (e.g., wide-based, limping or hobbling) MW, YH Grade 1 abnormal gait AE CTCAE: E11113 an abnormal gait AE that has moderate change in gait (e.g., wide-based, limping or hobbling); assistive device indicated; limiting instrumental activities of daily living MW, YH Grade 2 abnormal gait AE CTCAE: E11114 an anemia AE where hemoglobin (Hgb) is less than the lower limit of normal (LLN), which is 10.0 g/dL, 6.2 mmol/L, or 100 g/L. MW, YH Grade 1 anemia AE CTCAE: E10011 an anemia AE where hemoglobin (Hgb) is less than 10.0-8.0 g/dL, 6.2 -4.9 mmol/L, or 100 - 80 g/L. MW, YH Grade 2 anemia AE CTCAE: E10012 an anemia AE where hemoglobin (Hgb) is less than 8.0 g/dL, 4.9 mmol/L, or 80 g/L. MW, YH Grade 3 anemia AE CTCAE: E10013 a sinusitis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 sinusitis AE CTCAE: E11564 a sinusitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 sinusitis AE CTCAE: E11565 an allergy AE that has transient flushing or rash, drug fever <38 degrees C (<100.4 degrees F); intervention not indicated MW, YH Grade 1 allergy AE CTCAE: E11249 an allergy AE where intervention or infusion interruption indicated; responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics); prophylactic medications indicated for less than or equal to 24 hrs MW, YH Grade 2 allergy AE CTCAE: E11250 an allergy AE that is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) MW, YH Grade 3 allergy AE CTCAE: E11251 a dysphagia AE that is symptomatic, able to eat regular diet MW, YH Grade 1 dysphagia AE CTCAE: E10622 a dysphagia AE that is symptomatic and altered eating/swallowing MW, YH Grade 2 dysphagia AE CTCAE: E10623 a dysphagia AE that has severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated MW, YH Grade 3 dysphagia AE CTCAE: E10624 a platelet count decreased AE that is less than the lower limit of normal - 75,000/mm3; less than the lower limit of normal - 75.0 x 10e9 /L MW, YH Grade 1 platelet count decreased AE CTCAE: E12208 a platelet count decreased AE that is less than 75,000 - 50,000/mm3; less than 75.0 - 50.0 x 10e9 /L MW, YH Grade 2 platelet count decreased AE CTCAE: E12209 a platelet count decreased AE that is less than 50,000 - 25,000/mm3; less than 50.0 - 25.0 x 10e9 /L MW, YH Grade 3 platelet count decreased AE CTCAE: E12210 a platelet count decreased AE that is less than 25,000/mm3; less than 25.0 x 10e9 /L MW, YH Grade 4 platelet count decreased AE CTCAE: E12211 a vomiting AE that has 1 - 2 episodes (separated by 5 minutes) in 24 hrs MW, YH Grade 1 vomiting AE CTCAE: E11069 a vomiting AE that has 3 - 5 episodes (separated by 5 minutes) in 24 hrs MW, YH Grade 2 vomiting AE CTCAE: E11070 a vomiting AE that has 6 or more episodes (separated by 5 minutes) in 24 hrs; tube feeding, TPN or hospitalization indicated MW, YH Grade 3 vomiting AE CTCAE: E11071 a constipation AE that has occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema MW, YH Grade 1 constipation AE CTCAE: E10563 a constipation AE that has persistent symptoms with regular use of laxatives or enemas; limiting instrumental activities of daily living MW, YH Grade 2 constipation AE CTCAE: E10564 a constipation AE that has obstipation with manual evacuation indicated; limiting self care activities of daily living MW, YH Grade 3 constipation AE CTCAE: E10565 a lymphocyte count increased AE that is greater than 4000/mm3 - 20,000/mm3 MW, YH Grade 2 lymphocyte count increased AE CTCAE: E12196 a lymphocyte count increased AE that is greater than 20,000/mm3 MW, YH Grade 3 lymphocyte count increased AE CTCAE: E12197 a hypothermia AE that has 35 - greater than 32 degrees C; 95 - greater than 89.6 degrees F MW, YH Grade 2 hypothermia AE CTCAE: E11123 a hypothermia AE that has 32 - greater than 28 degrees C; 89.6 - greater than 82.4 degrees F MW, YH Grade 3 hypothermia AE CTCAE: E11124 a hypothermia AE that has less than or equal to 28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation) MW, YH Grade 4 hypothermia AE CTCAE: E11125 a hematoma AE that is localized or in a dependent area MW, YH Grade 1 hematoma AE CTCAE: E11667 a hematoma AE that is generalized MW, YH Grade 2 hematoma AE CTCAE: E11668 an aspartate aminotransferase level increased AE that is greater than the upper limit of normal to 3 times the upper limit of normal MW, YH Grade 1 aspartate aminotransferase level increased AE CTCAE: E12088 an aspartate aminotransferase level increased AE that is greater than 3 to 5 times the upper limit of normal MW, YH Grade 2 aspartate aminotransferase level increased AE CTCAE: E12089 an aspartate aminotransferase level increased AE that is greater than 5 to 20 times the upper limit of normal MW, YH Grade 3 aspartate aminotransferase level increased AE CTCAE: E12090 an aspartate aminotransferase level increased AE that is greater than 20 times the upper limit of normal MW, YH Grade 4 aspartate aminotransferase level increased AE CTCAE: E12091 an atrial fibrillation AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation MW, YH Grade 3 atrial fibrillation AE CTCAE: E10084 a blood alkaline phosphatase increased AE that is greater than the upper limit of normal to 2.5 times the upper limit of normal MW, YH Grade 1 blood alkaline phosphatase increased AE CTCAE: E12083 a blood alkaline phosphatase increased AE that is greater than 2.5 to 5 times the upper limit of normal MW, YH Grade 2 blood alkaline phosphatase increased AE CTCAE: E12084 a blood alkaline phosphatase increased AE that is greater than 5 to 20 times the upper limit of normal MW, YH Grade 3 blood alkaline phosphatase increased AE CTCAE: E12085 a blood alkaline phosphatase increased AE that is greater than 20 times the upper limit of normal MW, YH Grade 4 blood alkaline phosphatase increased AE CTCAE: E12086 a blood amylase level increased AE that is greater than the upper limit of normal - 1.5 times the upper limit of normal MW, YH Grade 1 blood amylase level increased AE CTCAE: E12213 a blood amylase level increased AE that is greater than 1.5 - 2.0 times the upper limit of normal MW, YH Grade 2 blood amylase level increased AE CTCAE: E12214 a blood amylase level increased AE that is greater than 2.0 - 5.0 times the upper limit of normal MW, YH Grade 3 blood amylase level increased AE CTCAE: E12215 a blood amylase level increased AE that is greater than 5.0 times the upper limit of normal MW, YH Grade 4 blood amylase level increased AE CTCAE: E12216 a blood bilirubin level increased AE that is greater than the upper limit of normal to 1.5 times the upper limit of normal MW, YH Grade 1 blood bilirubin level increased AE CTCAE: E12097 a blood bilirubin level increased AE that is greater than 1.5 to 3 times the upper limit of normal MW, YH Grade 2 blood bilirubin level increased AE CTCAE: E12098 a blood bilirubin level increased AEgreater than3.0 - 10.0 x upper limit of normal MW, YH Grade 3 blood bilirubin level increased AE CTCAE: E12099 a blood bilirubin level increased AE that is greater than 10 times the upper limit of normal MW, YH Grade 4 blood bilirubin level increased AE CTCAE: E12100 a blood cholesterol increased AE that is greater than the upper limit of normal to 300 mg/dL; greater than the upper limit of normal to 7.75 mmol/L MW, YH Grade 1 blood cholesterol increased AE CTCAE: E12128 a blood cholesterol increased AE that is greater than 300 - 400 mg/dL; greater than 7.75 - 10.34 mmol/L MW, YH Grade 2 blood cholesterol increased AE CTCAE: E12129 a blood cholesterol increased AE that is greater than 400 - 500 mg/dL; greater than 10.34 - 12.92 mmol/L MW, YH Grade 3 blood cholesterol increased AE CTCAE: E12130 a blood cholesterol increased AE that is greater than 500 mg/dL; greater than 12.92 mmol/L MW, YH Grade 4 blood cholesterol increased AE CTCAE: E12131 a blood creatinine level increased AE that is greater than 1 - 1.5 times the baseline; greater than the upper limit of normal - 1.5 times the upper limit of normal MW, YH Grade 1 blood creatinine level increased AE CTCAE: E12138 a blood creatinine level increased AE that is greater than 1.5 - 3.0 times the baseline; greater than 1.5 - 3.0 times the upper limit of normal MW, YH Grade 2 blood creatinine level increased AE CTCAE: E12139 a blood creatinine level increased AE that is greater than 3.0 times the baseline; greater than 3.0 - 6.0 times the upper limit of normal MW, YH Grade 3 blood creatinine level increased AE CTCAE: E12140 a blood creatinine level increased AE that is greater than 6.0 times the upper limit of normal MW, YH Grade 4 blood creatinine level increased AE CTCAE: E12141 a bone marrow depression AE categorized as mildly hypocellular or less than or equal to 25% reduction from normal cellularity for age MW, YH Grade 1 bone marrow depression AE CTCAE: E10023 a bone marrow depression AE categorized as moderately hypocellular or greater than 25 to less than 50% reduction from normal cellularity for age MW, YH Grade 2 bone marrow depression AE CTCAE: E10024 a bone marrow depression AE cateogirzed as severely hypocellular or greater than 50 to less than or equal to 75% reduction cellularity from normal for age MW, YH Grade 3 bone marrow depression AE CTCAE: E10025 a bone marrow depression AE categorized as aplastic persistent for longer than 2 weeks MW, YH Grade 4 bone marrow depression AE CTCAE: E10026 a breast infection AE that has local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 breast infection AE CTCAE: E11319 a breast infection AE that has severe infection; axillary adenitis; IV antibacterial, antifungal, or antiviral intervention indicated MW, YH Grade 3 breast infection AE CTCAE: E11320 a cardiac failure AE that is asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities MW, YH Grade 1 cardiac failure AE CTCAE: E10125 a cardiac failure AE that has symptoms with mild to moderate activity or exertion MW, YH Grade 2 cardiac failure AE CTCAE: E10126 a cardiac failure AE that has severe with symptoms at rest or with minimal activity or exertion; intervention indicated MW, YH Grade 3 cardiac failure AE CTCAE: E10127 a cardiac failure AE that has life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) MW, YH Grade 4 cardiac failure AE CTCAE: E10128 a cataract AE that is symptomatic; moderate decrease in visual acuity (20/40 or better) MW, YH Grade 2 cataract AE CTCAE: E10352 a cataract AE that is symptomatic with marked decrease in visual acuity (worse than 20/40 but better than 20/200); operative intervention indicated (e.g., cataract surgery) MW, YH Grade 3 cataract AE CTCAE: E10353 a cataract AE that is characterized by blindness (20/200 or worse) in the affected eye MW, YH Grade 4 cataract AE CTCAE: E10354 a catheter related infection AE that is localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 catheter related infection AE CTCAE: E11329 a catheter related infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 catheter related infection AE CTCAE: E11330 a colitis AE that has abdominal pain; mucus or blood in stool MW, YH Grade 2 colitis AE CTCAE: E10523 a colitis AE that has severe abdominal pain; change in bowel habits; medical intervention indicated; peritoneal signs MW, YH Grade 3 colitis AE CTCAE: E10524 a cytokine release syndrome AE that has a mild reaction; infusion interruption not indicated; intervention not indicated MW, YH Grade 1 cytokine release syndrome AE CTCAE: E11265 a cytokine release syndrome AE where therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for less than or equal to 24 hrs MW, YH Grade 2 cytokine release syndrome AE CTCAE: E11266 a cytokine release syndrome AEthat is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) MW, YH Grade 3 cytokine release syndrome AE CTCAE: E11267 a dental caries AE that has one or more dental caries, not involving the root MW, YH Grade 1 dental caries AE CTCAE: E10569 a dental caries AE that has dental caries involving the root MW, YH Grade 2 dental caries AE CTCAE: E10570 a dental caries AE that has dental caries resulting in pulpitis or periapical abscess or resulting in tooth loss MW, YH Grade 3 dental caries AE CTCAE: E10571 a device related infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 device related infection AE CTCAE: E11357 a disseminated intravascular coagulation AE that has laboratory findings with no bleeding MW, YH Grade 2 disseminated intravascular coagulation AE CTCAE: E10029 a disseminated intravascular coagulation AE that has laboratory findings and bleeding MW, YH Grade 3 disseminated intravascular coagulation AE CTCAE: E10030 an ejection fraction decreased AE where the resting ejection fraction (EF) 50 - 40%; 10 - 19% drop from baseline MW, YH Grade 2 ejection fraction decreased AE CTCAE: E12143 an ejection fraction decreased AE where the resting ejection fraction (EF) 39 - 20%; greater than 20% drop from baseline MW, YH Grade 3 ejection fraction decreased AE CTCAE: E12144 an ejection fraction decreased AE where the resting ejection fraction (EF) less than 20% MW, YH Grade 4 ejection fraction decreased AE CTCAE: E12145 an electrocardiogram qt prolonged AE where the QTc 450 - 480 ms MW, YH Grade 1 electrocardiogram qt prolonged AE CTCAE: E12147 an electrocardiogram qt prolonged AE where the QTc 481 - 500 ms MW, YH Grade 2 electrocardiogram qt prolonged AE CTCAE: E12148 an electrocardiogram qt prolonged AE where the QTc is greater than or equal to 501 ms on at least two separate ECGs MW, YH Grade 3 electrocardiogram qt prolonged AE CTCAE: E12149 an electrocardiogram qt prolonged AE where the QTc is greater than or equal to 501 or greater than 60 ms change from baseline and Torsade de pointes or polymorphic ventricular tachycardia or signs/symptoms of serious arrhythmia MW, YH Grade 4 electrocardiogram qt prolonged AE CTCAE: E12150 an enterocolitis AE that has abdominal pain; mucus or blood in stool MW, YH Grade 2 enterocolitis AE CTCAE: E10629 an enterocolitis AE that has severe or persistent abdominal pain; fever; ileus; peritoneal signs MW, YH Grade 3 enterocolitis AE CTCAE: E10630 a fall AE that is minor with no resultant injuries; intervention not indicated MW, YH Grade 1 fall AE CTCAE: E11688 a fall AE where hospitalization indicated MW, YH Grade 3 fall AE CTCAE: E11690 a febrile neutropenia AE categorized as anC less than 1000/mm3 with a single temperature of greater than 38.3 degrees C (101 degrees F) or a sustained temperature of greater than or equal to 38 degrees C (100.4 degrees F) for more than one hour. MW, YH Grade 3 febrile neutropenia AE CTCAE: E10034 a forced expiratory volume decreased AE where FEV1% (percentages of observed FEV1 and FVC related to their respective predicted values) 99 - 70% predicted MW, YH Grade 1 forced expiratory volume decreased AE CTCAE: E12157 a forced expiratory volume decreased AE where FEV1 60 - 69% MW, YH Grade 2 forced expiratory volume decreased AE CTCAE: E12158 a forced expiratory volume decreased AE where FEV1 50 - 59% MW, YH Grade 3 forced expiratory volume decreased AE CTCAE: E12159 a forced expiratory volume decreased AE where FEV1 is less than or equal to 49% MW, YH Grade 4 forced expiratory volume decreased AE CTCAE: E12160 a fracture AE that is symptomatic but non-displaced; immobilization indicated MW, YH Grade 2 fracture AE CTCAE: E11705 a fracture AE that has severe symptoms; displaced or open wound with bone exposure; disabling; operative intervention indicated MW, YH Grade 3 fracture AE CTCAE: E11706 a gamma-glutamyltransferase level increased AE that is greater than the upper limit of normal - 2.5 times upper limit of normal MW, YH Grade 1 gamma-glutamyltransferase level increased AE CTCAE: E12162 a gamma-glutamyltransferase level increased AE that is greater than 2.5 - 5.0 times the upper limit of normal MW, YH Grade 2 gamma-glutamyltransferase level increased AE CTCAE: E12163 a gamma-glutamyltransferase level increased AE that is greater than 5.0 - 20.0 times the upper limit of normal MW, YH Grade 3 gamma-glutamyltransferase level increased AE CTCAE: E12164 a gamma-glutamyltransferase level increased AE that is greater than 20.0 times the upper limit of normal MW, YH Grade 4 gamma-glutamyltransferase level increased AE CTCAE: E12165 a gastric ulcer AE that is symptomatic; altered GI function; medical intervention indicated; limiting instrumental activities of daily living MW, YH Grade 2 gastric ulcer AE CTCAE: E10729 a gastric ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care activities of daily living; disabling MW, YH Grade 3 gastric ulcer AE CTCAE: E10730 a gastritis AE that is symptomatic; altered GI function; medical intervention indicated MW, YH Grade 2 gastritis AE CTCAE: E10735 a gastritis AE that has severely altered eating or gastric function; TPN or hospitalization indicated MW, YH Grade 3 gastritis AE CTCAE: E10736 a hemolytic uremic syndrome AE that has evidence of RBC destruction (schistocytosis) without clinical consequences MW, YH Grade 1 hemolytic uremic syndrome AE CTCAE: E10044 a hemolytic uremic syndrome AE that has laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) MW, YH Grade 3 hemolytic uremic syndrome AE CTCAE: E10045 a hemolytic uremic syndrome AE that has life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) MW, YH Grade 4 hemolytic uremic syndrome AE CTCAE: E10046 a hemorrhoidal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 hemorrhoidal hemorrhage AE CTCAE: E10770 a hepatic failure AE that has asterixis; mild encephalopathy; limiting self care activities of daily living MW, YH Grade 3 hepatic failure AE CTCAE: E11212 a hepatic failure AE that has moderate to severe encephalopathy; coma; life-threatening consequences MW, YH Grade 4 hepatic failure AE CTCAE: E11213 a hepatitis viral AE that has symptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; reactivation of chronic hepatitis MW, YH Grade 3 hepatitis viral AE CTCAE: E11412 a hepatitis viral AE that has decompensated liver function (e.g., ascites, coagulopathy, encephalopathy, coma) MW, YH Grade 4 hepatitis viral AE CTCAE: E11413 an ileus AE that is symptomatic; altered GI function; bowel rest indicated MW, YH Grade 2 ileus AE CTCAE: E10813 an ileus AE that has severely altered GI function; TPN indicated MW, YH Grade 3 ileus AE CTCAE: E10814 an infusion related reaction AE that has mild transient reaction; infusion interruption not indicated; intervention not indicated MW, YH Grade 1 infusion related reaction AE CTCAE: E11128 an infusion related reaction AE where therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for less than or equal to 24 hrs MW, YH Grade 2 infusion related reaction AE CTCAE: E11129 an infusion related reaction AE that is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae MW, YH Grade 3 infusion related reaction AE CTCAE: E11130 an infusion site extravasation AE that has erythema with associated symptoms (e.g., edema, pain, induration, phlebitis) MW, YH Grade 2 infusion site extravasation AE CTCAE: E11134 an infusion site extravasation AE that has ulceration or necrosis; severe tissue damage; operative intervention indicated MW, YH Grade 3 infusion site extravasation AE CTCAE: E11135 an irritability AE that has mild; easily consolable MW, YH Grade 1 irritability AE CTCAE: E11145 an irritability AE that has moderate; limiting instrumental activities of daily living; increased attention indicated MW, YH Grade 2 irritability AE CTCAE: E11146 an irritability AE that has severe abnormal or excessive response; limiting self care activities of daily living; inconsolable MW, YH Grade 3 irritability AE CTCAE: E11147 a left ventricular dysfunction AE that has symptomatic due to drop in ejection fraction responsive to intervention MW, YH Grade 3 left venticular systolic dysfuction AE CTCAE: E10131 a left ventricular dysfunction AE chracterized as refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated MW, YH Grade 4 left ventricular systolic dysfuction AE CTCAE: E10132 a lipase increased AE that is greater than the upper limit of normal - 1.5 times upper limit of normal MW, YH Grade 1 lipase increased AE CTCAE: E12186 a lipase increased AE that is greater than 1.5 - 2.0 times upper limit of normal MW, YH Grade 2 lipase increased AE CTCAE: E12187 a lipase increased AE that is greater than 2.0 - 5.0 times upper limit of normal MW, YH Grade 3 lipase increased AE CTCAE: E12188 a lipase increased AE that is greater than 5.0 times upper limit of normal MW, YH Grade 4 lipase increased AE CTCAE: E12189 a localized edema AE that has localized to dependent areas, no disability or functional impairment MW, YH Grade 1 localized edema AE CTCAE: E11149 a lung infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 lung infection AE CTCAE: E11445 a lung infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 lung infection AE CTCAE: E11446 a lymphocyte count decreased AE that is less than the lower limit of normal - 800/mm3; less than the lower limit of normal - 0.8 x 10e9 /L MW, YH Grade 1 lymphocyte count decreased AE CTCAE: E12191 a lymphocyte count decreased AE that is less than 800 - 500/mm3; less than 0.8 - 0.5 x 10e9 /L MW, YH Grade 2 lymphocyte count decreased AE CTCAE: E12192 a lymphocyte count decreased AE that is less than 500 - 200/mm3; less than 0.5 - 0.2 x 10e9 /L MW, YH Grade 3 lymphocyte count decreased AE CTCAE: E12193 a lymphocyte count decreased AE that is less than 200/mm3; less than 0.2 x 10e9 /L MW, YH Grade 4 lymphocyte count decreased AE CTCAE: E12194 a myocarditis AE that has asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities MW, YH Grade 1 myocarditis AE CTCAE: E10158 a myocarditis AE that has symptoms with mild to moderate activity or exertion MW, YH Grade 2 myocarditis AE CTCAE: E10159 a myocarditis AE that has severe with symptoms at rest or with minimal activity or exertion; intervention indicated MW, YH Grade 3 myocarditis AE CTCAE: E10160 a myocarditis AE that has life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) MW, YH Grade 4 myocarditis AE CTCAE: E10161 a neutrophil count decreased AE that is less than the lower limit of normal - 1500/mm3; less than the lower limit of normal - 1.5 x 10e9 /L MW, YH Grade 1 neutrophil count decreased AE CTCAE: E12199 a neutrophil count decreased AE that is less than 1500 - 1000/mm3; less than 1.5 - 1.0 x 10e9 /L MW, YH Grade 2 neutrophil count decreased AE CTCAE: E12200 a neutrophil count decreased AE that is less than 1000 - 500/mm3; less than 1.0 - 0.5 x 10e9 /L MW, YH Grade 3 neutrophil count decreased AE CTCAE: E12201 a neutrophil count decreased AE that is less than 500/mm3; less than 0.5 x 10e9 /L MW, YH Grade 4 neutrophil count decreased AE CTCAE: E12202 an esophageal stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 esophageal stenosis AE CTCAE: E10672 an esophageal stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 esophageal stenosis AE CTCAE: E10673 an esophagitis AE that is symptomatic; altered eating/swallowing; oral supplements indicated MW, YH Grade 2 esophagitis AE CTCAE: E10689 an esophagitis AE that has severely altered eating/swallowing; tube feeding, TPN or hospitalization indicated MW, YH Grade 3 esophagitis AE CTCAE: E10690 an oral cavity fistula AE that is symptomatic; altered GI function MW, YH Grade 2 oral cavity fistula AE CTCAE: E10890 an oral cavity fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 oral cavity fistula AE CTCAE: E10891 a papilloedema AE that has a symptomatic decline in vision; visual field defect present sparing the central 20 degrees MW, YH Grade 2 papilledema AE CTCAE: E10413 a papilloedema AE that has a marked visual field defect (worse than 20/40 but better than 20/200) MW, YH Grade 3 papilledema AE CTCAE: E10414 a papilloedema AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 papilledema AE CTCAE: E10415 a pericardial effusion AE that has asymptomatic effusion size small to moderate MW, YH Grade 2 pericardial effusion AE CTCAE: E10173 a pericardial effusion AE that has effusion with physiologic consequences MW, YH Grade 3 pericardial effusion AE CTCAE: E10174 a portal hypertension AE that has decreased portal vein flow MW, YH Grade 2 portal hypertension AE CTCAE: E11239 a portal hypertension AE that has reversal/retrograde portal vein flow; associated with varices and/or ascites MW, YH Grade 3 portal hypertension AE CTCAE: E11240 a dermatitis radiation AE that has faint erythema or dry desquamation MW, YH Grade 1 dermatitis radiation AE CTCAE: E11676 a dermatitis radiation AE that has moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema MW, YH Grade 2 dermatitis radiation AE CTCAE: E11677 a dermatitis radiation AE that has moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion MW, YH Grade 3 dermatitis radiation AE CTCAE: E11678 a dermatitis radiation AE that has life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated MW, YH Grade 4 dermatitis radiation AE CTCAE: E11679 a rectal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 rectal hemorrhage AE CTCAE: E10958 a skin infection AE that is localized, local intervention indicated MW, YH Grade 1 skin infection AE CTCAE: E11569 a skin infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 skin infection AE CTCAE: E11570 a skin infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 skin infection AE CTCAE: E11571 a small intestinal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 small intestinal obstruction AE CTCAE: E11023 a small intestinal stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 small intestinal stenosis AE CTCAE: E11034 a small intestinal stenosis AE that is symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated MW, YH Grade 3 small intestinal stenosis AE CTCAE: E11035 a soft tissue infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 soft tissue infection AE CTCAE: E11580 a soft tissue infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 soft tissue infection AE CTCAE: E11581 a gastric hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 gastric hemorrhage AE CTCAE: E10709 a tracheitis AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 tracheitis AE CTCAE: E11600 a tracheitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 tracheitis AE CTCAE: E11601 an upper gastrointestinal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 upper gastrointestinal hemorrhage AE CTCAE: E11065 a urine output decreased AE that has oliguria (less than 80 ml in 8 hr) MW, YH Grade 3 urine output decreased AE CTCAE: E12218 a urine output decreased AE that has anuria (less than 240 ml in 24 hr) MW, YH Grade 4 urine output decreased AE CTCAE: E12219 a vaginal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 vaginal infection AE CTCAE: E11625 a vaginal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 vaginal infection AE CTCAE: E11626 a venous injury AE that is symptomatic (e.g., claudication); repair or revision not indicated MW, YH Grade 2 venous injury AE CTCAE: E12053 a venous injury AE that has severe symptoms; limiting self care activities of daily living; repair or revision indicated; disabling MW, YH Grade 3 venous injury AE CTCAE: E12054 a venous injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated MW, YH Grade 4 venous injury AE CTCAE: E12055 a weight increased AE that is 5 - less than 10% from baseline MW, YH Grade 1 weight increased AE CTCAE: E12225 a weight increased AE that is 10 - less than 20% from baseline MW, YH Grade 2 weight increased AE CTCAE: E12226 a weight increased AE that is greater than or equal to 20% from baseline MW, YH Grade 3 weight increased AE CTCAE: E12227 a wolff-parkinson-white syndrome AE that is symptomatic and incompletely controlled medically or controlled with procedure MW, YH Grade 3 Wolff-Parkinson-White syndrom AE CTCAE: E10247 a wound complication AE that has incisional separation of less than or equal to 25% of wound, no deeper than superficial fascia MW, YH Grade 1 wound complication AE CTCAE: E12058 a wound complication AE that has incisional separation greater than 25% of wound; local care indicated MW, YH Grade 2 wound complication AE CTCAE: E12059 a wound complication AE that has hernia without evidence of strangulation; fascial disruption/dehiscence; primary wound closure or revision by operative intervention indicated MW, YH Grade 3 wound complication AE CTCAE: E12060 a wound complication AE that has hernia with evidence of strangulation; major reconstruction flap, grafting, resection, or amputation indicated MW, YH Grade 4 wound complication AE CTCAE: E12061 a wound dehiscence AE that has incisional separation of less than or equal to 25% of wound, no deeper than superficial fascia MW, YH Grade 1 wound dehiscence AE CTCAE: E12064 a wound dehiscence AE that has incisional separation greater than 25% of wound with local care; asymptomatic hernia or symptomatic hernia without evidence of strangulation MW, YH Grade 2 wound dehiscence AE CTCAE: E12065 a wound dehiscence AE that has fascial disruption or dehiscence without evisceration; primary wound closure or revision by operative intervention indicated MW, YH Grade 3 wound dehiscence AE CTCAE: E12066 a wound dehiscence AE that has life-threatening consequences; symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated MW, YH Grade 4 wound dehiscence AE CTCAE: E12067 a multi-organ failure AE chracterized by shock with azotemia and acid-base disturbances; significant coagulation abnormalities MW, YH Grade 3 multi-organ failure AE CTCAE: E11156 a multi-organ failure AE that has life-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis) MW, YH Grade 4 multi-organ failure AE CTCAE: E11157 a restrictive cardiomyopathy AE that has symptomatic heart failure or other cardiac symptoms, responsive to intervention MW, YH Grade 3 restrictive cardiomyopathy AE CTCAE: E10193 a restrictive cardiomyopathy AE that has refractory heart failure or other poorly controlled cardiac symptoms MW, YH Grade 4 restrictive cardiomyopathy AE CTCAE: E10194 a complete atrioventricular block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) MW, YH Grade 3 atrioventricular block complete AE CTCAE: E10095 a Mobitz type I block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) MW, YH Grade 3 Mobitz type I block AE CTCAE: E10149 a Mobitz type II block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) MW, YH Grade 3 Mobitz type II atrioventricular block AE CTCAE: E10143 a hemoglobin level increased AE where the increase is greater than 0 - 2 gm/dL above upper limit of normal or above baseline if baseline is above upper limit of normal MW, YH Grade 1 hemoglobin level increased AE CTCAE: E12172 a hemoglobin level increased AE where the increase is greater than 2 - 4 gm/dL above the upper limit of normal or above baseline if baseline is above upper limit of normal MW, YH Grade 2 hemoglobin level increased AE CTCAE: E12173 a hemoglobin level increased AE where the increase is greater than 4 gm/dL above the upper limit of normal or above baseline if baseline is above upper limit of normal MW, YH Grade 3 hemoglobin level increased AE CTCAE: E12174 a right ventricular dysfunction AE that has asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities MW, YH Grade 1 right ventricular dysfuction AE CTCAE: E10197 a right ventricular dysfunction AE that has symptoms with mild to moderate activity or exertion MW, YH Grade 2 right ventricular dysfuction AE CTCAE: E10198 a right ventricular dysfunction AE that has severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated MW, YH Grade 3 right ventricular dysfuction AE CTCAE: E10199 a right ventricular dysfunction AE that has life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated MW, YH Grade 4 right ventricular dysfunction AE CTCAE: E10200 a Intraoperative hemorrhage AE where postoperative radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 intraoperative hemorrhage AE CTCAE: E11811 an uveitis AE that has anterior uveitis; medical intervention indicated MW, YH Grade 2 uveitis AE CTCAE: E10444 an uveitis AE that has posterior or pan-uveitis MW, YH Grade 3 uveitis AE CTCAE: E10445 an uveitis AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 uveitis AE CTCAE: E10446 a retinopathy AE that is symptomatic with moderate decrease in visual acuity (20/40 or better); limiting instrumental activities of daily living MW, YH Grade 2 retinopathy AE CTCAE: E10434 a retinopathy AE that is symptomatic with marked decrease in visual acuity (worse than 20/40); disabling; limiting self care activities of daily living MW, YH Grade 3 retinopathy AE CTCAE: E10435 a retinopathy AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 retinopathy AE CTCAE: E10436 a hearing loss AE for adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of 15 - 25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: subjective change in hearing in the absence of documented hearing loss. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift greater than20 dB at 8 kHz in at least one ear. MW, YH Grade 1 hearing loss AE CTCAE: E10277 a hearing loss AE for adults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of greater than25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: hearing loss but hearing aid or intervention not indicated; limiting instrumental activities of daily living. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift greater than20 dB at 4 kHz and above in at least one ear. MW, YH Grade 2 hearing loss AE CTCAE: E10278 a hearing loss AE for adults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of greater than25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated. Adults not enrolled in Monitoring Program: hearing loss with hearing aid or intervention indicated; limiting self care activities of daily living. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): hearing loss sufficient to indicate therapeutic intervention, including hearing aids; threshold shift greater than20 dB at 3 kHz and above in at least one ear; additional speech-language related services indicated. MW, YH Grade 3 hearing loss AE CTCAE: E10279 a hearing loss AE for adults: Decrease in hearing to profound bilateral loss (absolute threshold greater than80 dB HL at 2 kHz and above); non-servicable hearing. Pediatric: Audiologic indication for cochlear implant and additional speech-language related services indicated. MW, YH Grade 4 hearing loss AE CTCAE: E10280 a international normalized ratio increased AE that is greater than 1 - 1.5 times the upper limit of normal; greater than 1 - 1.5 times above baseline if on anticoagulation MW, YH Grade 1 international normalized ratio increased AE CTCAE: E12176 a international normalized ratio increased AE that is greater than 1.5 - 2.5 times the upper limit of normal; greater than 1.5 - 2.5 times above baseline if on anticoagulation MW, YH Grade 2 international normalized ratio increased AE CTCAE: E12177 a international normalized ratio increased AE that is greater than 2.5 times the upper limit of normal; greater than 2.5 times above baseline if on anticoagulation MW, YH Grade 3 international normalized ratio increased AE CTCAE: E12178 a fecal incontinence AE that has occasional use of pads required MW, YH Grade 1 fecal incontinence AE CTCAE: E10694 a fecal incontinence AE that has daily use of pads required MW, YH Grade 2 fecal incontinence AE CTCAE: E10695 a fecal incontinence AE that has severe symptoms; elective operative intervention indicated MW, YH Grade 3 fecal incontinence AE CTCAE: E10696 a thrombotic thrombocytopenic purpura AE that has evidence of RBC destruction (schistocytosis) without clinical consequences MW, YH Grade 1 thrombotic thrombocytopenic purpura AE CTCAE: E10062 a thrombotic thrombocytopenic purpura AE charaterized by laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) MW, YH Grade 3 thrombotic thrombocytopenic purpura AE CTCAE: E10063 a thrombotic thrombocytopenic purpura AE that has life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) MW, YH Grade 4 thrombotic thrombocytopenic purpura AE CTCAE: E10064 a glaucoma AE that has elevated intraocular pressure (EIOP) with single topical agent for intervention; no visual field deficit MW, YH Grade 1 glaucoma AE CTCAE: E10393 a glaucoma AE that has elevated intraocular pressure causing early visual field deficits; multiple topical or oral agents indicated; limiting instrumental activities of daily living MW, YH Grade 2 glaucoma AE CTCAE: E10394 a glaucoma AE that has elevated intraocular pressure causing marked visual field deficits (e.g., involving both superior and inferior visual fields); operative intervention indicated; limiting self care activities of daily living MW, YH Grade 3 glaucoma AE CTCAE: E10395 a glaucoma AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 glaucoma AE CTCAE: E10396 an anaphylaxis AE that has symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension MW, YH Grade 3 anaphylaxis AE CTCAE: E11255 a retinal detachment AE that has exudative and visual acuity 20/40 or better MW, YH Grade 2 retinal detachment AE CTCAE: E10422 a retinal detachment AE that has rhegmatogenous or exudative detachment; operative intervention indicated; decline in vision (worse than 20/40 but better than 20/200) MW, YH Grade 3 retinal detachment AE CTCAE: E10423 a retinal detachment AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 retinal detachment AE CTCAE: E10424 a hemolysis AE that has laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin) MW, YH Grade 1 hemolysis AE CTCAE: E10038 a hemolysis AE that has evidence of hemolysis and greater than or equal to 2 gm decrease in hemoglobin. MW, YH Grade 2 hemolysis AE CTCAE: E10039 a hemolysis AE where transfusion or medical intervention is indicated (e.g., steroids) MW, YH Grade 3 hemolysis AE CTCAE: E10040 an anal fistula AE that is symptomatic; altered GI function MW, YH Grade 2 anal fistula AE CTCAE: E10466 an anal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 anal fistula AE CTCAE: E10467 an atrial tachycardia AE where IV medication is indicated MW, YH Grade 3 atrial tachycardia AE CTCAE: E10169 an atrial tachycardia AE that has life-threatening consequences; incompletely controlled medically; cardioversion indicated MW, YH Grade 4 atrial tachycardia AE CTCAE: E10170 a cholecystitis AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 cholecystitis AE CTCAE: E11186 an autoimmune disorder AE that is asymptomatic; serologic or other evidence of autoimmune reaction, with normal organ function; intervention not indicated MW, YH Grade 1 autoimmune disorder AE CTCAE: E11259 an autoimmune disorder AE that has evidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism) MW, YH Grade 2 autoimmune disorder AE CTCAE: E11260 an autoimmune disorder AE that has autoimmune reactions involving major organ (e.g., colitis, anemia, myocarditis, kidney) MW, YH Grade 3 autoimmune disorder AE CTCAE: E11261 a spleen disorder AE that has incidental findings (e.g., Howell-Jolly bodies); mild degree of thrombocytosis and leukocytosis MW, YH Grade 1 spleen disorder AE CTCAE: E10057 a spleen disorder AE when prophylactic antibiotics are indicated MW, YH Grade 2 spleen disorder AE CTCAE: E10058 a burn AE that requires medical intervention; minimal debridement indicated MW, YH Grade 2 burn AE CTCAE: E11671 a burn AE that requires moderate to major debridement or reconstruction indicated MW, YH Grade 3 burn AE CTCAE: E11672 a papulopustular rash AE that has papules and/or pustules covering less than 10% body surface area which may or may not be associated with symptoms of pruritus or tenderness MW, YH Grade 1 papulopustular rash AE CTCAE: E11492 a papulopustular rash AE that has papules and/or pustules covering 10-30% body surface area, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental activities of daily living MW, YH Grade 2 papulopustular rash AE CTCAE: E11493 a papulopustular rash AE that has papules and/or pustules covering greater than 30% body surface area, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care activities of daily living; associated with local superinfection with oral antibiotics indicated MW, YH Grade 3 papulopustular rash AE CTCAE: E11494 a papulopustular rash AE that has papules and/or pustules covering any % body surface area, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences MW, YH Grade 4 papulopustular rash AE CTCAE: E11495 an acute coronary syndrome AE that has symptomatic, progressive angina; cardiac enzymes normal; hemodynamically stable MW, YH Grade 2 acute coronary syndrome AE CTCAE: E10067 an acute coronary syndrome AE that has symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically stable MW, YH Grade 3 acute coronary syndrome AE CTCAE: E10068 an acute coronary syndrome AE that has symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically unstable MW, YH Grade 4 acute coronary syndrome AE CTCAE: E10069 an aortic valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging MW, YH Grade 1 aortic valve disease AE CTCAE: E10072 an aortic valve disease AE that has symptomatic; moderate regurgitation or stenosis by imaging MW, YH Grade 2 aortic valve disease AE CTCAE: E10073 an aortic valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention MW, YH Grade 3 aortic valve disease AE CTCAE: E10074 an aortic valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) MW, YH Grade 4 aortic valve disease AE CTCAE: E10075 an asystole AE that has periods of asystole; non-urgent medical management indicated MW, YH Grade 1 asystole AE CTCAE: E10078 a constrictive pericarditis AE that has symptomatic heart failure or other cardiac symptoms, responsive to intervention MW, YH Grade 3 constrictive pericarditis AE CTCAE: E10121 a constrictive pericarditis AE that has refractory heart failure or other poorly controlled cardiac symptoms MW, YH Grade 4 constrictive pericarditis AE CTCAE: E10122 a mitral valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging MW, YH Grade 1 mitral valve disease AE CTCAE: E10135 a mitral valve disease AE that has asymptomatic; moderate regurgitation or stenosis by imaging MW, YH Grade 2 mitral valve disease AE CTCAE: E10136 a mitral valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention MW, YH Grade 3 mitral valve disease AE CTCAE: E10137 a mitral valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) MW, YH Grade 4 mitral valve disease AE CTCAE: E10138 a pulmonary valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging MW, YH Grade 1 pulmonary valve disease AE CTCAE: E10187 a pulmonary valve disease AE that has asymptomatic; moderate regurgitation or stenosis by imaging MW, YH Grade 2 pulmonary valve disease AE CTCAE: E10188 a pulmonary valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention MW, YH Grade 3 pulmonary valve disease AE CTCAE: E10189 a pulmonary valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) MW, YH Grade 4 pulmonary valve disease AE CTCAE: E10190 a tricuspid valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis MW, YH Grade 1 tricuspid valve disease AE CTCAE: E10225 a tricuspid valve disease AE that is asymptomatic; moderate regurgitation or stenosis by imaging MW, YH Grade 2 tricuspid valve disease AE CTCAE: E10226 a tricuspid valve disease AE that is symptomatic; severe regurgitation or stenosis; symptoms controlled with medical intervention MW, YH Grade 3 tricuspid valve disease AE CTCAE: E10227 a tricuspid valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) MW, YH Grade 4 tricuspid valve disease AE CTCAE: E10228 an external ear inflammation AE that has external otitis with erythema or dry desquamation MW, YH Grade 1 external ear inflammation AE CTCAE: E10267 an external ear inflammation AE that has external otitis with moist desquamation, edema, enhanced cerumen or discharge; tympanic membrane perforation; tympanostomy MW, YH Grade 2 external ear inflammation AE CTCAE: E10268 an external ear inflammation AE that has external otitis with mastoiditis; stenosis or osteomyelitis; necrosis of soft tissue or bone MW, YH Grade 3 external ear inflammation AE CTCAE: E10269 an external ear inflammation AE where urgent operative intervention indicated MW, YH Grade 4 external ear inflammation AE CTCAE: E10270 a middle ear inflammation AE that has serous otitis MW, YH Grade 1 middle ear inflammation AE CTCAE: E10282 a middle ear inflammation AE that has serous otitis, medical intervention indicated MW, YH Grade 2 middle ear inflammation AE CTCAE: E10283 a middle ear inflammation AE that has mastoiditis; necrosis of canal soft tissue or bone MW, YH Grade 3 middle ear inflammation AE CTCAE: E10284 a delayed puberty AE that has no breast development by age 13 yrs for females; testes volume of <3 cc or no Tanner Stage 2 development by age 14.5 yrs for males MW, YH Grade 2 delayed puberty AE CTCAE: E10309 a delayed puberty AE that has no breast development by age 14 yrs for females; no increase in testes volume or no Tanner Stage 2 by age 16 yrs for males; hormone replacement indicated MW, YH Grade 3 delayed puberty AE CTCAE: E10310 a growth accelerated AE that has greater than or equal to +2 SD (standard deviation) above mid parental height or target height MW, YH Grade 2 growth accelerated AE CTCAE: E10318 a precocious puberty AE that has physical signs of puberty with no biochemical markers for females younger than 8 years and males younger than 9 years MW, YH Grade 1 precocious puberty AE CTCAE: E10341 a precocious puberty AE that has physical signs and biochemical markers of puberty for females younger than 8 years and males younger than 9 years MW, YH Grade 2 precocious puberty AE CTCAE: E10342 a corneal ulcer AE that has limiting self care activities of daily living declining vision (worse than 20/40 but better than 20/200) MW, YH Grade 3 corneal ulcer AE CTCAE: E10361 a corneal ulcer AE that has perforation or blindness (20/200 or worse) in the affected eye MW, YH Grade 4 corneal ulcer AE CTCAE: E10362 a dry eye AE that is asymptomatic; clinical or diagnostic observations only; mild symptoms relieved by lubricants MW, YH Grade 1 dry eye AE CTCAE: E10364 a dry eye AE that has a decrease in visual acuity (<20/40); limiting self care activities of daily living MW, YH Grade 3 dry eye AE CTCAE: E10366 a keratitis AE that has a decline in vision (worse than 20/40 but better than 20/200); limiting self care activities of daily living MW, YH Grade 3 keratitis AE CTCAE: E10399 a keratitis AE that has perforation or blindness (20/200 or worse) in the affected eye MW, YH Grade 4 keratitis AE CTCAE: E10400 a night blindness AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 night blindness AE CTCAE: E10405 an optic nerve disorder AE that has limiting vision of the affected eye (20/40 or better) MW, YH Grade 2 optic nerve disorder AE CTCAE: E10408 an optic nerve disorder AE that has limiting vision in the affected eye (worse than 20/40 but better than 20/200) MW, YH Grade 3 optic nerve disorder AE CTCAE: E10409 an optic nerve disorder AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 optic nerve disorder AE CTCAE: E10410 a retinal tear AE where laser therapy or pneumopexy indicated MW, YH Grade 2 retinal tear AE CTCAE: E10426 a retinal tear AE where vitroretinal surgical repair indicated MW, YH Grade 3 retinal tear AE CTCAE: E10427 a retinal tear AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 retinal tear AE CTCAE: E10428 a retinal vascular disorder AE where topical medication indicated MW, YH Grade 2 retinal vascular disorder AE CTCAE: E10430 a retinal vascular disorder AE where intravitreal medication; operative intervention indicated MW, YH Grade 3 retinal vascular disorder AE CTCAE: E10431 a scleral disorder AE that is symptomatic, limiting instrumental activities of daily living; moderate decrease in visual acuity (20/40 or better) MW, YH Grade 2 scleral disorder AE CTCAE: E10439 a scleral disorder AE that is symptomatic, limiting self care activities of daily living; marked decrease in visual acuity (worse than 20/40) MW, YH Grade 3 scleral disorder AE CTCAE: E10440 a scleral disorder AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 scleral disorder AE CTCAE: E10441 a vitreous hemorrhage AE that has limiting self care activities of daily living; vitrectomy indicated MW, YH Grade 3 vitreous hemorrhage AE CTCAE: E10450 a vitreous hemorrhage AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 4 vitreous hemorrhage AE CTCAE: E10451 an anal necrosis AE where TPN or hospitalization indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 anal necrosis AE CTCAE: E10483 an anal stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 anal stenosis AE CTCAE: E10492 an anal stenosis AE that is symptomatic and severely altered GI function; non-emergent operative intervention indicated; TPN or hospitalization indicated MW, YH Grade 3 anal stenosis AE CTCAE: E10493 a bloating AE that has no change in bowel function or oral intake MW, YH Grade 1 bloating AE CTCAE: E10509 a bloating AE that is symptomatic, decreased oral intake; change in bowel function MW, YH Grade 2 bloating AE CTCAE: E10510 a cecal hemorrhage AE that has moderate symptoms; medical intervention or minor cauterization indicated MW, YH Grade 2 cecal hemorrhage AE CTCAE: E10513 a cecal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 cecal hemorrhage AE CTCAE: E10514 a colonic fistula AE that is symptomatic; altered GI function MW, YH Grade 2 colonic fistula AE CTCAE: E10529 a colonic fistula AE that has severely altered GI function; bowel rest, TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 colonic fistula AE CTCAE: E10530 a colonic hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 colonic hemorrhage AE CTCAE: E10536 a colonic obstruction AE that is symptomatic; altered GI function MW, YH Grade 2 colonic obstruction AE CTCAE: E10541 a colonic ulcer AE that is symptomatic; altered GI function MW, YH Grade 2 colonic ulcer AE CTCAE: E10558 a colonic ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling MW, YH Grade 3 colonic ulcer AE CTCAE: E10559 a duodenal fistula AE that is symptomatic; altered GI function MW, YH Grade 2 duodenal fistula AE CTCAE: E10584 a duodenal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 duodenal fistula AE CTCAE: E10585 a duodenal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 duodenal hemorrhage AE CTCAE: E10591 a duodenal obstruction AE that is symptomatic; altered GI function MW, YH Grade 2 duodenal obstruction AE CTCAE: E10596 a duodenal stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 duodenal stenosis AE CTCAE: E10607 a duodenal stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 duodenal stenosis AE CTCAE: E10608 an esophageal fistula AE that is symptomatic; altered GI function MW, YH Grade 2 esophageal fistula AE CTCAE: E10641 an esophageal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 esophageal fistula AE CTCAE: E10642 an esophageal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 esophageal hemorrhage AE CTCAE: E10648 an esophageal necrosis AE that has inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 esophageal necrosis AE CTCAE: E10652 an esophageal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 esophageal obstruction AE CTCAE: E10657 an esophageal ulcer AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 esophageal ulcer AE CTCAE: E10678 an esophageal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care activities of daily living; disabling MW, YH Grade 3 esophageal ulcer AE CTCAE: E10679 an esophageal varices hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 esophageal varices hemorrhage AE CTCAE: E10684 a gastric fistula AE that is symptomatic; altered GI function MW, YH Grade 2 gastric fistula AE CTCAE: E10702 a gastric fistula AE that has severely altered GI function; bowel rest; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 gastric fistula AE CTCAE: E10703 a gastric necrosis AE that has inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 gastric necrosis AE CTCAE: E10713 a gastric stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 gastric stenosis AE CTCAE: E10723 a gastric stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 gastric stenosis AE CTCAE: E10724 a gastrointestinal fistula AE that is symptomatic; altered GI function MW, YH Grade 2 gastrointestinal fistula AE CTCAE: E10751 a gastrointestinal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated MW, YH Grade 3 gastrointestinal fistula AE CTCAE: E10752 a gastroparesis AE that has mild nausea, early satiety and bloating, able to maintain caloric intake on regular diet MW, YH Grade 1 gastroparesis AE CTCAE: E10760 a gastroparesis AE that has moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention MW, YH Grade 2 gastroparesis AE CTCAE: E10761 a gastroparesis AE that has weight loss; refractory to medical intervention; unable to maintain nutrition orally MW, YH Grade 3 gastroparesis AE CTCAE: E10762 an ileal fistula AE that is symptomatic; altered GI function MW, YH Grade 2 ileal fistula AE CTCAE: E10779 an ileal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 ileal fistula AE CTCAE: E10780 an ileal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 ileal hemorrhage AE CTCAE: E10786 an ileal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 ileal obstruction AE CTCAE: E10791 an ileal stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 ileal stenosis AE CTCAE: E10802 an ileal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 ileal stenosis AE CTCAE: E10803 an ileal ulcer AE that is symptomatic; altered GI function MW, YH Grade 2 ileal ulcer AE CTCAE: E10808 an ileal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling MW, YH Grade 3 ileal ulcer AE CTCAE: E10809 an intra-abdominal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 intra-abdominal hemorrhage AE CTCAE: E10819 a jejunal fistula AE that is symptomatic; altered GI function MW, YH Grade 2 jejunal fistula AE CTCAE: E10824 a jejunal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 jejunal fistula AE CTCAE: E10825 ajejunal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 jejunal hemorrhage AE CTCAE: E10831 a jejunal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 jejunal obstruction AE CTCAE: E10836 a jejunal stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 jejunal stenosis AE CTCAE: E10847 a jejunal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 jejunal stenosis AE CTCAE: E10848 a jejunal ulcer AE that is symptomatic; altered GI function MW, YH Grade 2 jejunal ulcer AE CTCAE: E10853 a jejunal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling MW, YH Grade 3 jejunal ulcer AE CTCAE: E10854 a lower gastrointestinal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 lower gastrointestinal hemorrhage AE CTCAE: E10864 a malabsorption AE where altered diet; oral intervention indicated MW, YH Grade 2 malabsorption AE CTCAE: E10868 a malabsorption AE that has inability to aliment adequately; TPN indicated MW, YH Grade 3 malabsorption AE CTCAE: E10869 an obstruction gastric AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 obstruction gastric AE CTCAE: E10884 an oral hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 oral hemorrhage AE CTCAE: E10901 a pancreatic duct stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 pancreatic duct stenosis AE CTCAE: E10910 a pancreatic duct stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 pancreatic duct stenosis AE CTCAE: E10911 a pancreatic fistula AE that is symptomatic; altered GI function MW, YH Grade 2 pancreatic fistula AE CTCAE: E10916 a pancreatic fistula AE that has severely altered GI function; tube feeding or TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 pancreatic fistula AE CTCAE: E10917 a pancreatic hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 pancreatic hemorrhage AE CTCAE: E10923 a pancreatic necrosis AE where tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 pancreatic necrosis AE CTCAE: E10927 a peritoneal necrosis AE where tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 peritoneal necrosis AE CTCAE: E10940 a proctitis AE that has rectal discomfort, intervention not indicated MW, YH Grade 1 proctitis AE CTCAE: E10944 a proctitis AE that has symptoms (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental activities of daily living MW, YH Grade 2 proctitis AE CTCAE: E10945 a proctitis AE that has severe symptoms; fecal urgency or stool incontinence; limiting self care activities of daily living MW, YH Grade 3 proctitis AE CTCAE: E10946 a rectal fistula AE that is symptomatic; altered GI function MW, YH Grade 2 rectal fistula AE CTCAE: E10951 a rectal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 rectal fistula AE CTCAE: E10952 a rectal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 rectal obstruction AE CTCAE: E10973 a rectal stenosis AE that is symptomatic; altered GI function MW, YH Grade 2 rectal stenosis AE CTCAE: E10988 a rectal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 rectal stenosis AE CTCAE: E10989 a rectal ulcer AE that is symptomatic; altered GI function (e.g. altered dietary habits, vomiting, diarrhea) MW, YH Grade 2 rectal ulcer AE CTCAE: E10994 a rectal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling MW, YH Grade 3 rectal ulcer AE CTCAE: E10995 a retroperitoneal hemorrhage AE where transfusion, medical, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 3 retroperitoneal hemorrhage AE CTCAE: E11000 a salivary gland fistula AE that is symptomatic; altered GI function; tube feeding indicated MW, YH Grade 2 salivary gland fistula AE CTCAE: E11011 a salivary gland fistula AE that has severely altered GI function; hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 salivary gland fistula AE CTCAE: E11012 a tooth discoloration AE that has surface stains MW, YH Grade 1 tooth discoloration AE CTCAE: E11053 an edema limbs AE that has 5 - 10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection MW, YH Grade 1 edema limbs AE CTCAE: E11087 an edema limbs AE that has more than 10 to 30% inter-limb discrepancy in volume or circumference at point of greatest visible difference; readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental activities of daily living MW, YH Grade 2 edema limbs AE CTCAE: E11088 an edema limbs AE that has more than 30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care activities of daily living MW, YH Grade 3 edema limbs AE CTCAE: E11089 an edema trunk AE that has swelling or obscuration of anatomic architecture on close inspection MW, YH Grade 1 edema trunk AE CTCAE: E11091 an edema trunk AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental activities of daily living MW, YH Grade 2 edema trunk AE CTCAE: E11092 an edema trunk AE that has gross deviation from normal anatomic contour; limiting self care activities of daily living MW, YH Grade 3 edema trunk AE CTCAE: E11093 A neck edema AE that has moderate neck edema; slight obliteration of anatomic landmarks; limiting instrumental activities of daily living MW, YH Grade 2 neck edema AE CTCAE: E11161 a neck edema AE that has generalized neck edema (e.g., difficulty in turning neck); limiting self care activities of daily living MW, YH Grade 3 neck edema AE CTCAE: E11162 a bile duct stenosis AE that is symptomatic; altered GI function; IV fluids indicated <24 hrs MW, YH Grade 2 bile duct stenosis AE CTCAE: E11175 a bile duct stenosis AE that has severely altered GI function; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 bile duct stenosis AE CTCAE: E11176 a biliary fistula AE that has severely altered GI function; TPN indicated; endoscopic intervention indicated; elective operative intervention indicated MW, YH Grade 3 biliary fistula AE CTCAE: E11181 a gallbladder fistula AE that is symptomatic or severely altered GI function; TPN indicated; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 gallbladder fistula AE CTCAE: E11192 a gallbladder obstruction AE that is symptomatic; altered GI function; IV fluids indicated <24 hrs MW, YH Grade 2 gallbladder obstruction AE CTCAE: E11200 a gallbladder obstruction AE that is symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated MW, YH Grade 3 gallbladder obstruction AE CTCAE: E11201 a hepatic hemorrhage AE where transfusion indicated MW, YH Grade 3 hepatic hemorrhage AE CTCAE: E11218 a perforation bile duct AE where radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 perforation bile duct AE CTCAE: E11235 an abdominal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 abdominal infection AE CTCAE: E11283 an anorectal infection AE that is localized; local intervention indicated MW, YH Grade 1 anorectal infection AE CTCAE: E11287 an anorectal infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 anorectal infection AE CTCAE: E11288 an anorectal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 anorectal infection AE CTCAE: E11289 an appendicitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 appendicitis AE CTCAE: E11293 an arteritis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 arteritis infective AE CTCAE: E11302 a biliary tract infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 biliary tract infection AE CTCAE: E11306 a bladder infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 bladder infection AE CTCAE: E11310 a bladder infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 bladder infection AE CTCAE: E11311 a bone infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 bone infection AE CTCAE: E11315 a bronchial infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 bronchial infection AE CTCAE: E11324 a bronchial infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 bronchial infection AE CTCAE: E11325 a cecal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 cecal infection AE CTCAE: E11334 a cervicitis infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 cervicitis infection AE CTCAE: E11338 a cervicitis infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 cervicitis infection AE CTCAE: E11339 a conjunctivitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 conjunctivitis infective AE CTCAE: E11343 a conjunctivitis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 conjunctivitis infective AE CTCAE: E11344 a corneal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 corneal infection AE CTCAE: E11348 a corneal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 corneal infection AE CTCAE: E11349 a cranial nerve infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 cranial nerve infection AE CTCAE: E11353 a duodenal infection AE that has moderate symptoms; medical intervention indicated (e.g., oral antibiotics) MW, YH Grade 2 duodenal infection AE CTCAE: E11361 a duodenal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 duodenal infection AE CTCAE: E11362 an encephalitis infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities MW, YH Grade 3 encephalitis infection AE CTCAE: E11366 an encephalomyelitis infection AE when IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 encephalomyelitis infection AE CTCAE: E11370 an endocarditis infective AE when IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 endocarditis infective AE CTCAE: E11374 an endophthalmitis AE that has blindness (20/200 or worse) MW, YH Grade 4 endophthalmitis AE CTCAE: E11380 an enterocolitis infectious AE that has the passage of more than 3 unformed stools per 24 hrs or duration of illness longer than 48 hrs; moderate abdominal pain MW, YH Grade 2 enterocolitis infectious AE CTCAE: E11382 an enterocolitis infectious AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated MW, YH Grade 3 enterocolitis infectious AE CTCAE: E11383 an esophageal infection AE where local intervention indicated (e.g., oral antibiotic, antifungal, antiviral) MW, YH Grade 2 esophageal infection AE CTCAE: E11387 an esophageal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 esophageal infection AE CTCAE: E11388 an eye infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 eye infection AE CTCAE: E11392 an eye infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 eye infection AE CTCAE: E11393 an eye infection AE that has life-threatening consequences; urgent intervention indicated; enucleation MW, YH Grade 4 eye infection AE CTCAE: E11394 a gallbladder infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 gallbladder infection AE CTCAE: E11397 a gum infection AE where local therapy indicated (swish and swallow) MW, YH Grade 1 gum infection AE CTCAE: E11401 a gum infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 gum infection AE CTCAE: E11402 a gum infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 gum infection AE CTCAE: E11403 a hepatic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 hepatic infection AE CTCAE: E11407 a infective myositis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 infective myositis AE CTCAE: E11422 a infective myositis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 infective myositis AE CTCAE: E11423 a joint infection AE that is localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); needle aspiration indicated (single or multiple) MW, YH Grade 2 joint infection AE CTCAE: E11427 a joint infection AE where arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage) MW, YH Grade 3 joint infection AE CTCAE: E11428 a kidney infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 kidney infection AE CTCAE: E11432 a lip infection AE that is localized, local intervention indicated MW, YH Grade 1 lip infection AE CTCAE: E11441 a lip infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 lip infection AE CTCAE: E11442 a lip infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 lip infection AE CTCAE: E11443 a lymph gland infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 lymph gland infection AE CTCAE: E11450 a lymph gland infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 lymph gland infection AE CTCAE: E11451 a mediastinal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 mediastinal infection AE CTCAE: E11455 a mucosal infection AE that is localized, local intervention indicated MW, YH Grade 1 mucosal infection AE CTCAE: E11463 a mucosal infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 mucosal infection AE CTCAE: E11464 a mucosal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 mucosal infection AE CTCAE: E11465 a nail infection AE that is localized, local intervention indicated MW, YH Grade 1 nail infection AE CTCAE: E11469 a nail infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 nail infection AE CTCAE: E11470 a nail infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 nail infection AE CTCAE: E11471 an otitis externa AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 otitis externa AE CTCAE: E11473 an otitis externa AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 otitis externa AE CTCAE: E11474 an ovarian infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 ovarian infection AE CTCAE: E11483 an ovarian infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 ovarian infection AE CTCAE: E11484 a pancreas infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 pancreas infection AE CTCAE: E11488 a paronychia AE that has nail fold edema or erythema; disruption of the cuticle MW, YH Grade 1 paronychia AE CTCAE: E11498 a paronychia AE where localized intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); nail fold edema or erythema with pain; associated with discharge or nail plate separation; limiting instrumental activities of daily living MW, YH Grade 2 paronychia AE CTCAE: E11499 a paronychia AE where surgical intervention or IV antibiotics indicated; limiting self care activities of daily living MW, YH Grade 3 paronychia AE CTCAE: E11500 a pelvic infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 pelvic infection AE CTCAE: E11502 a pelvic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 pelvic infection AE CTCAE: E11503 a penile infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 penile infection AE CTCAE: E11507 a penile infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 penile infection AE CTCAE: E11508 a periorbital infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 periorbital infection AE CTCAE: E11512 a periorbital infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 periorbital infection AE CTCAE: E11513 a peripheral nerve infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 peripheral nerve infection AE CTCAE: E11517 a peripheral nerve infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 peripheral nerve infection AE CTCAE: E11518 a peritoneal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 peritoneal infection AE CTCAE: E11522 a phlebitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 phlebitis infective AE CTCAE: E11531 a phlebitis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 phlebitis infective AE CTCAE: E11532 a pleural infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 pleural infection AE CTCAE: E11536 a pleural infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 pleural infection AE CTCAE: E11537 a prostate infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 prostate infection AE CTCAE: E11541 a prostate infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 prostate infection AE CTCAE: E11542 a rhinitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 rhinitis infective AE CTCAE: E11549 a salivary gland infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 salivary gland infection AE CTCAE: E11551 a salivary gland infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 salivary gland infection AE CTCAE: E11552 a scrotal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 scrotal infection AE CTCAE: E11556 a scrotal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 scrotal infection AE CTCAE: E11557 a small intestine infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 small intestine infection AE CTCAE: E11575 a small intestine infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 small intestine infection AE CTCAE: E11576 a splenic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 splenic infection AE CTCAE: E11585 a stoma site infection AE that is localized, local intervention indicated MW, YH Grade 1 stoma site infection AE CTCAE: E11589 a stoma site infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 stoma site infection AE CTCAE: E11590 a stoma site infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 stoma site infection AE CTCAE: E11591 a tooth infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 tooth infection AE CTCAE: E11595 a tooth infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 tooth infection AE CTCAE: E11596 an upper respiratory infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 upper respiratory infection AE CTCAE: E11605 an upper respiratory infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 upper respiratory infection AE CTCAE: E11606 a urethral infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 urethral infection AE CTCAE: E11610 a urethral infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 urethral infection AE CTCAE: E11611 a uterine infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 uterine infection AE CTCAE: E11620 a uterine infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 uterine infection AE CTCAE: E11621 a vulval infection AE that is localized, local intervention indicated MW, YH Grade 1 vulval infection AE CTCAE: E11630 A vulval infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 2 vulval infection AE CTCAE: E11631 a vulval infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 vulval infection AE CTCAE: E11632 a wound infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 2 wound infection AE CTCAE: E11636 a wound infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 wound infection AE CTCAE: E11637 an ankle fracture AE that is mild; non-surgical intervention indicated MW, YH Grade 1 ankle fracture AE CTCAE: E11641 an ankle fracture AE that is limiting instrumental activities of daily living; operative intervention indicated MW, YH Grade 2 ankle fracture AE CTCAE: E11642 an ankle fracture AE that is limiting self care activities of daily living; elective surgery indicated MW, YH Grade 3 ankle fracture AE CTCAE: E11643 an aortic injury AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated MW, YH Grade 3 aortic injury AE CTCAE: E11645 an aortic injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated MW, YH Grade 4 aortic injury AE CTCAE: E11646 an arterial injury AE that is symptomatic (e.g., claudication); repair or revision not indicated MW, YH Grade 2 arterial injury AE CTCAE: E11650 an arterial injury AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated MW, YH Grade 3 arterial injury AE CTCAE: E11651 an arterial injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated MW, YH Grade 4 arterial injury AE CTCAE: E11652 a biliary anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 biliary anastomotic leak AE CTCAE: E11657 a bladder anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 bladder anastomotic leak AE CTCAE: E11663 an esophageal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 esophageal anastomotic leak AE CTCAE: E11684 a fallopian tube anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 fallopian tube anastomotic leak AE CTCAE: E11694 a fallopian tube perforation AE that has life-threatening consequences; urgent operative intervention indicated (e.g., organ resection) MW, YH Grade 4 fallopian tube perforation AE CTCAE: E11701 a gastric anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 gastric anastomotic leak AE CTCAE: E11712 a gastrointestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 gastrointestinal anastomotic leak CTCAE: E11718 a gastrointestinal stoma necrosis AE that is a superficial necrosis; intervention not indicated MW, YH Grade 2 gastrointestinal stoma necrosis CTCAE: E11722 a hip fracture AE that has a hairline fracture; mild pain; limiting instrumental activities of daily living; non-surgical intervention indicated MW, YH Grade 2 hip fracture AE CTCAE: E11727 a hip fracture AE that has severe pain; hospitalization or intervention indicated for pain control (e.g., traction); operative intervention indicated MW, YH Grade 3 hip fracture AE CTCAE: E11728 a hip fracture AE that has life-threatening consequences; symptoms associated with neurovascular compromise MW, YH Grade 4 hip fracture AE CTCAE: E11729 an injury to carotid artery AE that has severe symptoms; limiting self care activities of daily living (e.g., transient cerebral ischemia); repair or revision indicated MW, YH Grade 3 injury to carotid artery AE CTCAE: E11731 an injury to jugular vein AE that is symptomatic limiting self care activities of daily living; disabling; repair or revision indicated MW, YH Grade 3 injury to jugular vein AE CTCAE: E11738 an injury to superior vena cava AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated MW, YH Grade 3 injury to superior vena cava AE CTCAE: E11744 a injury to superior vena cava AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated MW, YH Grade 4 injury to superior vena cava AE CTCAE: E11745 an intestinal stoma leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 intestinal stoma leak AE CTCAE: E11756 an intestinal stoma leak AE that has severe symptoms; IV fluids, tube feeding, or TPN indicated greater than or equal to 24 hrs; elective operative intervention indicated MW, YH Grade 3 intestinal stoma leak AE CTCAE: E11761 an intestinal stoma site bleeding AE that has minimal bleeding identified on clinical exam; intervention not indicated MW, YH Grade 1 intestinal stoma site bleeding AE CTCAE: E11765 an intestinal stoma site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated MW, YH Grade 3 intestinal stoma site bleeding AE CTCAE: E11767 an intraoperative arterial injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative arterial injury AE CTCAE: E11771 an intraoperative arterial injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative arterial injury AE CTCAE: E11772 an intraoperative arterial injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative arterial injury AE CTCAE: E11773 an intraoperative breast injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative breast injury AE CTCAE: E11777 an intraoperative breast injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative breast injury AE CTCAE: E11778 an intraoperative breast injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative breast injury AE CTCAE: E11779 an intraoperative cardiac injury AE where primary repair of injured organ/structure indicated MW, YH Grade 3 intraoperative cardiac injury AE CTCAE: E11783 an intraoperative ear injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative ear injury AE CTCAE: E11787 an intraoperative ear injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative ear injury AE CTCAE: E11788 an intraoperative ear injury AE where complete resection of injured organ/structure indicated; disabling (e.g., impaired hearing; impaired balance) MW, YH Grade 3 intraoperative ear injury AE CTCAE: E11789 an intraoperative endocrine injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative endocrine injury AE CTCAE: E11793 an intraoperative endocrine injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative endocrine injury AE CTCAE: E11794 an intraoperative endocrine injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative endocrine injury AE CTCAE: E11795 an intraoperative gastrointestinal injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative gastrointestinal injury AE CTCAE: E11799 an intraoperative gastrointestinal injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative gastrointestinal injury AE CTCAE: E11800 an intraoperative gastrointestinal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative gastrointestinal injury AE CTCAE: E11801 a lintraoperative head and neck injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 lintraoperative head and neck injury AE CTCAE: E11805 a lintraoperative head and neck injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 lintraoperative head and neck injury AE CTCAE: E11806 a lintraoperative head and neck injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 lintraoperative head and neck injury AE CTCAE: E11807 an intraoperative hepatobiliary injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative hepatobiliary injury AE CTCAE: E11815 an intraoperative hepatobiliary injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative hepatobiliary injury AE CTCAE: E11816 an intraoperative hepatobiliary injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative hepatobiliary injury AE CTCAE: E11817 an intraoperative musculoskeletal injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative musculoskeletal injury AE CTCAE: E11821 an intraoperative musculoskeletal injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative musculoskeletal injury AE CTCAE: E11822 an intraoperative musculoskeletal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative musculoskeletal injury AE CTCAE: E11823 an intraoperative neurological injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative neurological injury AE CTCAE: E11827 an intraoperative neurological injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative neurological injury AE CTCAE: E11828 an intraoperative neurological injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative neurological injury AE CTCAE: E11829 an intraoperative ocular injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative ocular injury AE CTCAE: E11833 an intraoperative ocular injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative ocular injury AE CTCAE: E11834 an intraoperative ocular injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative ocular injury AE CTCAE: E11835 an intraoperative renal injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative renal injury AE CTCAE: E11839 an intraoperative renal injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative renal injury AE CTCAE: E11840 an intraoperative renal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative renal injury AE CTCAE: E11841 an intraoperative reproductive tract injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative reproductive tract injury AE CTCAE: E11845 an intraoperative reproductive tract injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative reproductive tract injury AE CTCAE: E11846 an intraoperative reproductive tract injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative reproductive tract injury AE CTCAE: E11847 an intraoperative respiratory injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative respiratory injury AE CTCAE: E11851 an intraoperative respiratory injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative respiratory injury AE CTCAE: E11852 an intraoperative respiratory injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative respiratory injury AE CTCAE: E11853 an intraoperative skin injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative skin injury AE CTCAE: E11857 an intraoperative skin injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative skin injury AE CTCAE: E11858 an intraoperative skin injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative skin injury AE CTCAE: E11859 an intraoperative splenic injury AE where primary repair of injured organ/structure indicated MW, YH Grade 2 intraoperative splenic injury AE CTCAE: E11863 an intraoperative splenic injury AE where resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative splenic injury AE CTCAE: E11864 an intraoperative urinary injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative urinary injury AE CTCAE: E11868 an intraoperative urinary injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative urinary injury AE CTCAE: E11869 an intraoperative urinary injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative urinary injury AE CTCAE: E11870 an intraoperative venous injury AE where primary repair of injured organ/structure indicated MW, YH Grade 1 intraoperative venous injury AE CTCAE: E11874 an intraoperative venous injury AE where partial resection of injured organ/structure indicated MW, YH Grade 2 intraoperative venous injury AE CTCAE: E11875 an intraoperative venous injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 3 intraoperative venous injury AE CTCAE: E11876 a kidney anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 kidney anastomotic leak AE CTCAE: E11882 a large intestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 large intestinal anastomotic leak AE CTCAE: E11888 a pancreatic anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 pancreatic anastomotic leak AE CTCAE: E11894 a pharyngeal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 pharyngeal anastomotic leak AE CTCAE: E11900 a postoperative hemorrhage AE that has moderate bleeding; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 2 postoperative hemorrhage AE CTCAE: E11905 a postoperative hemorrhage AE where transfusion indicated of greather than or equal to 2 units (10 cc/kg for pediatrics) pRBCs beyond protocol specification; urgent radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 postoperative hemorrhage AE CTCAE: E11906 a postoperative thoracic procedure complication AE when the patient is extubated within 24 - 72 hrs postoperatively MW, YH Grade 2 postoperative thoracic procedure complication AE CTCAE: E11910 a postoperative thoracic procedure complication AE when the patient is extubated more than 72 hrs postoperatively, but before tracheostomy indicated MW, YH Grade 3 postoperative thoracic procedure complication AE CTCAE: E11911 a postoperative thoracic procedure complication AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) MW, YH Grade 3 postoperative thoracic procedure complication AE CTCAE: E11912 a prolapse of intestinal stoma AE that is asymptomatic; reducible MW, YH Grade 1 prolapse of intestinal stoma AE CTCAE: E11915 a prolapse of intestinal stoma AE that is recurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental activities of daily living MW, YH Grade 2 prolapse of intestinal stoma AE CTCAE: E11916 a prolapse of urostomy AE treated with local care or maintenance; minor revision indicated MW, YH Grade 2 prolapse of urostomy AE CTCAE: E11922 a prolapse of urostomy AE that has dysfunctional stoma; elective operative intervention or major stomal revision indicated MW, YH Grade 3 prolapse of urostomy AE CTCAE: E11923 a radiation recall reaction (dermatologic) AE that has faint erythema or dry desquamation MW, YH Grade 1 radiation recall reaction (dermatologic) AE CTCAE: E11927 a radiation recall reaction (dermatologic) AE that has moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema MW, YH Grade 2 radiation recall reaction (dermatologic) AE CTCAE: E11928 a radiation recall reaction (dermatologic) AE that has moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion MW, YH Grade 3 radiation recall reaction (dermatologic) AE CTCAE: E11929 a radiation recall reaction (dermatologic) AE that has life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated MW, YH Grade 4 radiation recall reaction (dermatologic) AE CTCAE: E11930 a rectal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 rectal anastomotic leak AE CTCAE: E11935 a seroma AE that is symptomatic; simple aspiration indicated MW, YH Grade 2 seroma AE CTCAE: E11940 a seroma AE that is symptomatic, elective radiologic or operative intervention indicated MW, YH Grade 3 seroma AE CTCAE: E11941 a small intestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 small intestinal anastomotic leak AE CTCAE: E11945 a spermatic cord anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 spermatic cord anastomotic leak AE CTCAE: E11951 a spinal fracture AE that has mild back pain; nonprescription analgesics indicated MW, YH Grade 1 spinal fracture AE CTCAE: E11955 a spinal fracture AE that has moderate back pain; prescription analgesics indicated; limiting instrumental activities of daily living MW, YH Grade 2 spinal fracture AE CTCAE: E11956 a spinal fracture AE that has severe back pain; hospitalization or intervention indicated for pain control (e.g., vertebroplasty); limiting self care activities of daily living; disability MW, YH Grade 3 spinal fracture AE CTCAE: E11957 a spinal fracture AE that has life-threatening consequences; symptoms associated with neurovascular compromise MW, YH Grade 4 spinal fracture AE CTCAE: E11958 a stenosis of gastrointestinal stoma AE that is symptomatic; IV fluids indicated <24 hrs; manual dilation at bedside MW, YH Grade 2 stenosis of gastrointestinal stoma AE CTCAE: E11961 a stenosis of gastrointestinal stoma AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 stenosis of gastrointestinal stoma AE CTCAE: E11962 a tracheal hemorrhage AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated MW, YH Grade 3 tracheal hemorrhage AE CTCAE: E11972 a tracheal obstruction AE that has partial asymptomatic obstruction on examination (e.g., visual, radiologic or endoscopic) MW, YH Grade 1 tracheal obstruction AE CTCAE: E11976 a tracheal obstruction AE that is symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental activities of daily living MW, YH Grade 2 tracheal obstruction AE CTCAE: E11977 a tracheal obstruction AE that has stridor; radiologic or endoscopic intervention indicated (e.g., stent, laser); limiting self care activities of daily living MW, YH Grade 3 tracheal obstruction AE CTCAE: E11978 a tracheal obstruction AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) MW, YH Grade 4 tracheal obstruction AE CTCAE: E11979 a tracheostomy site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated MW, YH Grade 3 tracheostomy site bleeding AE CTCAE: E11984 an ureteric anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 ureteric anastomotic leak AE CTCAE: E11990 an urethral anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 urethral anastomotic leak CTCAE: E11996 a urostomy leak AESevere symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 urostomy leak AE CTCAE: E12002 a urostomy obstruction AE that is symptomatic; dilation or endoscopic repair or stent placement indicated MW, YH Grade 2 urostomy obstruction AE CTCAE: E12007 a urostomy site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated MW, YH Grade 3 urostomy site bleeding AE CTCAE: E12014 a urostomy stenosis AE that is symptomatic but no hydronephrosis, no sepsis or no renal dysfunction; dilation or endoscopic repair or stent placement indicated MW, YH Grade 2 urostomy stenosis AE CTCAE: E12018 a urostomy stenosis AE that is symptomatic (e.g., hydronephrosis, or renal dysfunction); elective operative intervention indicated MW, YH Grade 3 urostomy stenosis AE CTCAE: E12019 a uterine anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 uterine anastomotic leak AE CTCAE: E12025 a vaginal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 vaginal anastomotic leak AE CTCAE: E12037 a vas deferens anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 vas deferens anastomotic leak AE CTCAE: E12043 a vascular access complication AE that has device dislodgement, blockage, leak, or malposition; device replacement indicated MW, YH Grade 2 vascular access complication AE CTCAE: E12047 A vascular access complication AE that has deep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure) MW, YH Grade 3 vascular access complication AE CTCAE: E12048 a vascular access complication AE that has embolic event including pulmonary embolism or life-threatening thrombus MW, YH Grade 4 vascular access complication AE CTCAE: E12049 a blood antidiuretic hormone abnormal AE where hospitalization indicated MW, YH Grade 3 blood antidiuretic hormone abnormal AE CTCAE: E12095 a blood corticotrophin decreased AE where hospitalization indicated MW, YH Grade 3 blood corticotrophin decreased AE CTCAE: E12104 a carbon monoxide diffusing capacity decreased AE that is 3 - 5 units below lower limit of normal; for follow-up, a decrease of 3 - 5 units (ml/min/mm Hg) below the baseline value MW, YH Grade 1 carbon monoxide diffusing capacity decreased AE CTCAE: E12113 a carbon monoxide diffusing capacity decreased AE that is 6 - 8 units below lower limit of normal; for follow-up, an asymptomatic decrease of greater than 5 - 8 units (ml/min/mm Hg) below the baseline value MW, YH Grade 2 carbon monoxide diffusing capacity decreased AE CTCAE: E12114 a carbon monoxide diffusing capacity decreased AE that is an asymptomatic decrease of greater than 8 units drop; greater than 5 units drop along with the presence of pulmonary symptoms (e.g. , greater than Grade 2 hypoxia or greater than Grade 2 or higher dyspnea) MW, YH Grade 3 carbon monoxide diffusing capacity decreased AE CTCAE: E12115 a cardiac troponin I increased AE that has levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer MW, YH Grade 1 cardiac troponin I increased AE CTCAE: E12117 a cardiac troponin I increased AE that has levels consistent with myocardial infarction as defined by the manufacturer MW, YH Grade 3 cardiac troponin I increased AE CTCAE: E12118 a cardiac troponin T increased AE that has levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer MW, YH Grade 1 cardiac troponin T increased AE CTCAE: E12120 a cardiac troponin T increased AE that has levels consistent with myocardial infarction as defined by the manufacturer MW, YH Grade 3 cardiac troponin T increased AE CTCAE: E12121 a CD4 lymphocytes decreased AE that is less than the lower limit of normal to 500/mm3 or 0.5 x 10e9 /L MW, YH Grade 1 CD4 lymphocytes decreased AE CTCAE: E12123 a CD4 lymphocytes decreased AE that is less than 500 - 200/mm3; less than 0.5 - 0.2 x 10e9 /L MW, YH Grade 2 CD4 lymphocytes decreased AE CTCAE: E12124 a CD4 lymphocytes decreased AE that is less than 200 - 50/mm3; less than 0.2 x 0.05 - 10e9 /L MW, YH Grade 3 CD4 lymphocytes decreased AE CTCAE: E12125 a CD4 lymphocytes decreased AE that is less than 50/mm3; less than 0.05 x 10e9 /L MW, YH Grade 4 CD4 lymphocytes decreased AE CTCAE: E12126 a CPK increased AE that is greater than the upper limit of normal to 2.5 times the upper limit of normal MW, YH Grade 1 CPK increased AE CTCAE: E12133 a CPK increased AE that is greater than 2.5 -5 times the upper limit of normal MW, YH Grade 2 CPK increased AE CTCAE: E12134 a CPK increased AE that is greater than 5 to 10 times the upper limit of normal MW, YH Grade 3 CPK increased AE CTCAE: E12135 a CPK increased AE that is greater than 10 times the upper limit of normal MW, YH Grade 4 CPK increased AE CTCAE: E12136 a fibrinogen decreased AE that is less than 1.0 - 0.75 times the lower limit of normal or less than 25% decrease from baseline MW, YH Grade 1 fibrinogen decreased AE CTCAE: E12152 a fibrinogen decreased AE that is less than 0.75 - 0.5 times the lower limit of normal or 25 - less than 50% decrease from baseline MW, YH Grade 2 fibrinogen decreased AE CTCAE: E12153 a fibrinogen decreased AE that is less than 0.5 - 0.25 times the lower limit of normal or 50 - less than 75% decrease from baseline MW, YH Grade 3 fibrinogen decreased AE CTCAE: E12154 a fibrinogen decreased AE that is less than 0.25 times the lower limit of normal or 75% decrease from baseline or absolute value less than 50 mg/dL MW, YH Grade 4 fibrinogen decreased AE CTCAE: E12155 a haptoglobin decreased AE that is less than the lower limit of normal MW, YH Grade 1 haptoglobin decreased AE CTCAE: E12170 a pancreatic enzymes decreased AE that is less than the lower limit of normal and asymptomatic MW, YH Grade 1 pancreatic enzymes decreased AE CTCAE: E12204 a pancreatic enzymes decreased AE that has an increase in stool frequency, bulk, or odor; steatorrhea MW, YH Grade 2 pancreatic enzymes decreased AE CTCAE: E12205 a pancreatic enzymes decreased AE that has sequelae of absorption deficiency MW, YH Grade 3 pancreatic enzymes decreased AE CTCAE: E12206 a vital capacity abnormal AE that has 90 - 75% of predicted value MW, YH Grade 1 vital capacity abnormal AE CTCAE: E12221 a vital capacity abnormal AE that is less than 75 - 50% of predicted value; limiting instrumental activities of daily living MW, YH Grade 2 vital capacity abnormal AE CTCAE: E12222 a vital capacity abnormal AE that is less than 50% of predicted value; limiting self care activities of daily living MW, YH Grade 3 vital capacity abnormal AE CTCAE: E12223 a seizure AE that occurs in a pregnant women that follows a preeclampsia. Such a seizure is not related to an existing brain condition. JS, YH WEB: https://en.wikipedia.org/wiki/Eclampsia WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000899.htm 10014129 eclampsia AE a gastric disorder AE that shows the body under stress, causing acute erosion, bleeding and ulcers, stomach or duodenal mucosa damage collectively. The main clinical manifestations include upper gastrointestinal bleeding and a small perforation. QL, YH AGML AE WEB: http://medmantic.com/wiki/Acute_Gastric_Mucosal_Lesion 急性胃黏膜损害 10000753 acute gastric mucosal lesion AE a bowel sounds abnormal AE that shows an increased amount of bowel sounds. QL, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm hyperactive bowel sounds AE 肠鸣音亢进 10048720 bowel sounds increased AE UMLS CUI: C0232694 a bowel sounds abnormal AE that shows a decreased amount of bowel sounds. QL, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm hypoactive bowel sounds AE 肠鸣音减弱 bowel sounds decreased AE UMLS CUI: C0232695 a gastrointestinal disorder AE that shows an abnormal amount of bowel sounds. QL, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm 肠鸣音异常 bowel sounds abnormal AE UMLS CUI: C0159060 a bowel sounds abnormal AE that shows an cesssation of any bowel sounds. QL, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm 肠鸣音停止 肠鸣音消失 cessation of bowel sounds AE UMLS CUI: C0857330 a migraine AE which shows a migraine preceded or accompanied by sensory warning signs or symptoms, such as flashes of light, blind spots, or tingling in your hand or face. SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/migraine-with-aura/basics/definition/con-20030404 10027607 migraine with aura AE a hearing disorder AE with an abnormally disproportionate increase in the sensation of loudness in response to auditory stimuli of normal volume QL, YH WEB: https://en.wikipedia.org/wiki/Hyperacusis 听觉过敏 10052526 hyperacusia AE a back pain AE that occurs at the low back QL, YH low back pain AE WEB: https://en.wikipedia.org/wiki/Low_back_pain 下背痛 腰痛 lumbago AE a paralysis AE which occurs in a single limb, usually an arm SJ, YH WEB: http://en.wikipedia.org/wiki/Monoplegia 10027926 monoplegia AE a behavior and neurological AE which results in abnormal, disturbed or impaired functioning of a muscle, nerve, or center that affects or produces movement SJ, YH WEB: http://connection.ebscohost.com/c/reference-entries/23076155/motor-dysfunction 10061296 motor dysfunction AE a discomfort AE that occurs at the musculoskeletal level and results in musculoskeletal pain that affects the bones, muscles, ligaments, tendons, and nerves SJ, YH musculoskeletal pain AE WEB: http://my.clevelandclinic.org/health/diseases_conditions/hic_musculoskeletal_pain 10053156 musculoskeletal discomfort AE a musculoskeletal and connective tissue AE which results in a disease or abnormal condition of the musculoskeletal system SJ, YH 10048592 musculoskeletal disorder AE a urinary system AE which shows reduced excretion of urine SJ, YH WEB: http://c.merriam-webster.com/medlineplus/oliguria 10030302 oliguria AE a hypotension AE that happens during a medical procedure SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/low-blood-pressure/basics/definition/con-20032298 10062300 procedural hypotension AE a digestive system AE that occurs at esophagus YH, MW 食道副作用 esophagus AE a digestive system AE that occurs at anus YH, MW anus AE a digestive system AE that occurs at duodenum MW, YH duodenum AE QL, YH URL http://howshealth.com/kidney-pain-location-causes-symptoms-treatment/#percussion 肾区叩击痛 a renal pain AE that shows the pain in the kidney area identified by a percussion procedure. kidney area percussion pain AE a medical procedure by which a medical professional investigates the body of a patient for signs of disease. QL, YH WEB: http://www.webmd.com/a-to-z-guides/annual-physical-examinations WEB: https://en.wikipedia.org/wiki/Physical_examination 10071941 physical examination a physical test by which a surface is tapped to determine the underlying structure, and is used in clinical examinations to assess the condition of the thorax or abdomen. QL, YH percussion test WEB: https://en.wikipedia.org/wiki/Percussion_(medicine) 10051720 percussion procedure a urine analysis result abnomal AE that shows cylindrical structures produced by the kidney and present in the urine. QL, YH urinary casts present AE WEB: http://medical-dictionary.thefreedictionary.com/cylindruria 管型尿 10011730 10067534 cylindruria AE a hepatitis AE that resutls in a hepatitis A viral infection. JX, YH hepatitis A AE WEB: https://en.wikipedia.org/wiki/Hepatitis_A 10019719 hepatitis A AE a connective tissue disorder AE that shows an inflammation of the fascia, the connective tissue surrounding muscles, blood vessels, and nerves. JX, YH WEB: https://en.wikipedia.org/wiki/Fasciitis 筋膜炎 10016228 fasciitis AE A tendon disorder AE that led to the formation of fibrous tissue in the tendon area JX, YH WEB: http://study.com/academy/lesson/fibrous-connective-tissue-function-types.html 10016662 fibrosis tendinous AE a fasciitis AE that shows an inflammation of the muscle fascia, the connective tissue surrounding muscles. JX, YH WEB: https://en.wikipedia.org/wiki/Fasciitis 肌筋膜炎 10052443 myofascitis AE an eye disorder AE that causes visual disturbance and interfere with normal sight. JX, YH WEB: http://www.healthline.com/symptom/visual-disturbance 10047543 visual disturbance AE a cognitive disturbance AE that has mild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated MW, YH Grade 1 cognitive disturbance AE CTCAE: E12618 a cognitive disturbance AE that has moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated MW, YH Grade 2 cognitive disturbance AE CTCAE: E12619 a cognitive disturbance AE that has severe cognitive disability; significant impairment of work/school/life performance MW, YH Grade 3 cognitive disturbance AE CTCAE: E12620 an abortion AE that results in a retention of dead products of conception in utero for more than 8 weeks. JX, YH WEB: http://medical-dictionary.thefreedictionary.com/missed+abortion 10000230 abortion missed AE an edema AE that has an outcome of swelling in the eye. JX, YH 10052139 eye edema AE Oral discomfort AE is a discomfort AE that shows an uncomfortable feeling in the oral. JX, YH 口腔不适 10030973 oral discomfort AE a female reproductive system AE that has an outcome of the presence of a fluid-filled sac within a patient's ovary. JX, YH WEB: https://en.wikipedia.org/wiki/Ovarian_cyst 10033132 ovarian cyst AE a female reproductive system AE that occurs in the placental area. JX, YH WEB: https://en.wikipedia.org/wiki/Placental_disease 10035132 placental disorder AE an inflammation AE that occurs at the central nervous system. JX, YH WEB: https://en.wikipedia.org/wiki/Central_nervous_system_disease 中枢神经系统炎症 central nervous system inflammation AE a nervous system AE that has outcome of lesion in the area of central nervous system. JX, YH WEB: http://www.emedicinehealth.com/brain_lesions_lesions_on_the_brain/article_em.htm 10051290 central nervous system lesion AE a behavioral and neurological AE is characterized by motor coordination problems with daily activities. JX, YH WEB: http://www.healthline.com/symptom/clumsiness 10009696 clumsiness AE a behavioral and neurological AE is a deficiency in the ability to write, primarily handwriting, but also coherence. JX, YH WEB: https://en.wikipedia.org/wiki/Dysgraphia 10058319 dysgraphia AE a sensory neuropathy AE than is the medical term for a sensation that exactly resembles that of small insects crawling on (or under) the skin. JX, YH WEB: https://en.wikipedia.org/wiki/Formication 10017062 formication AE a paresis AE that shows muscle weakness of the entire left or right side of the body. JX, YH WEB: https://en.wikipedia.org/wiki/Hemiparesis 轻偏瘫 10019465 hemiparesis AE an immunology and allergy investigation result abnormal AE that results in an increased level of an immunoglobulin. JX, YH WEB: http://www.webmd.com/a-to-z-guides/immunoglobulins immunoglobulin increased AE a urinary system AE that shows abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE. JX, YH WEB: http://sideeffects.embl.de/se/C0042035/pt 10027561 micturition disorder AE a muscle twitch AE that has an outcome of contractions involuntary of muscle. JX, YH 肌肉不自觉收缩 10028293 muscle contractions involuntary AE a nervous system AE that describes any neurologic deficit related to the spinal cord. JX, YH WEB: https://en.wikipedia.org/wiki/Myelopathy 脊髓病 10028570 myelopathy AE a optic neuritis AE that has outcome of optic neuritis in retrobulbar. JX, YH WEB: https://en.wikipedia.org/wiki/Optic_neuritis 球后视神经炎 10030945 optic neuritis retrobulbar AE a eye AE that is an area of partial alteration in the field of vision consisting of a partially diminished or entirely degenerated visual acuity that is surrounded by a field of normal – or relatively well-preserved – vision. JX, YH WEB: https://en.wikipedia.org/wiki/Scotoma 暗点 10039729 scotoma AE A thyroiditis AE where the body interprets the thyroid glands and its hormone products T3, T4 and TSH as threats, therefore producing special antibodies that target the thyroid’s cells, thereby destroying it. JX, YH https://en.wikipedia.org/wiki/Autoimmune_thyroiditis 自我免疫性甲状腺炎 10049046 autoimmune thyroiditis AE a colitis AE that is a disease that causes inflammation and sores (ulcers) in the lining of the large intestine. JX, YH ulcerative colitis AE WEB: http://www.webmd.com/ibd-crohns-disease/ulcerative-colitis/ulcerative-colitis-topic-overview 溃疡性结肠炎 10009900 colitis ulcerative AE an abnormal stool AE that shows pale or clay-colored stool. JX, YH faeces pale AE WEB: http://www.healthline.com/symptom/pale-stools 大便苍白 10016102 feces pale AE a tumor AE that is a group of blood cell tumors that develop from lymphatic cells. JX, YH WEB: https://en.wikipedia.org/wiki/Lymphoma 淋巴瘤 10025310 lymphoma AE a paresis AE that affects a single limb, usually an arm. JX, YH WEB: https://en.wikipedia.org/wiki/Monoplegia 单肢轻瘫 10027925 monoparesis AE a eye AE that refers to weakness (-paresis) or paralysis (-plegia) of one or more extraocular muscles which are responsible for eye movements. JX, YH WEB: https://en.wikipedia.org/wiki/Ophthalmoparesis 眼肌麻痹 10030875 ophthalmoplegia AE a eye AE that has outcome of slight differences in pupil size. JX, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003314.htm 瞳孔不等 10037538 pupils unequal AE quadriplegia AE is paralysis caused by illness or injury that results in the partial or total loss of use of all four limbs and torso. JX, YH Tetraplegia WEB: https://en.wikipedia.org/wiki/Tetraplegia 四肢麻痹 10037714 quadriplegia AE a CSF white blood cell count increased AE with more than the normal number of lymphocytes in cerebrospinal fluid (CSF). JX, YH 脑脊液细胞增多 10035551 pleocytosis AE a behavior and neurological AE that shows an decreased preformance JX, YH WEB: https://en.wikipedia.org/wiki/Performance_status 体能下降 10048919 performance status decreased AE a skin AS that shows a mass at the skin. JX, YH skin tumor AE 10067868 skin mass AE an abnormal stool AE that shows an abnomal color in the feces. JX, YH faeces discoloured AE WEB: http://www.buzzle.com/articles/stool-colors-and-what-they-mean.html 10016100 feces discolored AE an investigation result abnormal AE that shows an abnormal ultrasound scan result. JX, YH WEB: http://www.nhs.uk/conditions/ultrasound-scan/Pages/Introduction.aspx 10061606 ultrasound scan abnormal AE an injection site AE that shows some substance release from an injection site. JX, YH 10065600 injection site discharge AE a tumor AE that has an outcome of the presense of a mass that arises from the axillary. JX, YH WEB: http://www.rightdiagnosis.com/sym/axillary_mass.htm 腋窝肿块 10049021 axillary mass AE a behavioral and neurological AE that involves a slowing-down of thought and a reduction of physical movements in an individual. JX, YH motormental retardation AE psychomotor impairment AE WEB: https://en.wikipedia.org/wiki/Psychomotor_retardation 精神运动性阻滞 10037213 psychomotor retardation AE an abscess AE that occurs at an injection-site. Note that an abscess is a collection of pus that has built up within a tissue of the body. JX, YH WEB: https://en.wikipedia.org/wiki/Abscess 10022044 injection site abscess AE an ulcer AE that occurs at an injection-site. JX, YH WEB: https://en.wikipedia.org/wiki/Ulcer 10022105 injection site ulcer AE a viral infection AE that is caused by a disseminated Bacillus Calmette-Guerin bacterial infection. JX, YH disseminated Bacillus Calmette-Guerin infection AE 10069636 disseminated BCG infection AE a paresis AE that shows a muscular weakness affecting all four extremities. JX, YH quadriparesis AE WEB: http://www.medilexicon.com/medicaldictionary.php?t=91062 tetraparesis AE a menstrual disorder AE that shows an extremely light menstrual blood flow QL, YH hypomenorrhoea AE WEB: https://en.wikipedia.org/wiki/Hypomenorrhea 月经减少 10021032 hypomenorrhea AE a menstrual disorder AE that shows a menstrual period with abnormally heavy flow and falls under the larger category of abnormal uterine bleeding (AUB) QL, YH hypermenorrhea AE WEB: https://en.wikipedia.org/wiki/Menorrhagia menorrhagia AE a male reproductive system AE in which spermatozoa in seminal fluid are dead or motionless QL, YH WEB: https://en.wikipedia.org/wiki/Necrospermia 死精 10074729 necrospermia AE MP: MP_0009325 a reproductive system AE that results in diminished ability to produce live offspring JX, LW, YH WEB: https://en.wikipedia.org/wiki/Infertility 生育能力下降 10042391 subfertility AE MP: MP_0001921 a reproductive system AE that results in an inability to conceive for at least one year after trying and having unprotected sex. QL, YH WEB: http://www.mayoclinic.org/diseases-conditions/infertility/basics/definition/con-20034770 不孕不育 10021926 infertility AE MP: MP_0001921 an endocrine investigation result abnormal AE that is characterized by a lower than normal level of estrogen, the primary sex hormone in women QL, YH estrogen deficiency AE hypoestrogenism AE WEB: http://www.md-health.com/Low-Estrogen.html WEB: https://en.wikipedia.org/wiki/Hypoestrogenism 性激素水平下降 10015519 low estrogen level AE a hemorrhage AE that occurs at the uterus, but it is not related to menstruation. The irregular and unpredictable bleeding usually comes from a dysfunctional endometrium. QL, YH WEB: http://emedicine.medscape.com/article/257007-overview 功能性子宫出血 10013908 dysfunctional uterine bleeding AE MESH: D008796 a testicular disorder AE that has a loss of testicular volume QL, YH WEB: https://en.wikipedia.org/wiki/Testicular_atrophy 睾丸萎缩 10043298 testicular atrophy AE an aplastic anemia AE that results in the suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. QL, YH PRCA AE red-cell aplasia, pure WEB: http://emedicine.medscape.com/article/205695-overview 纯红再障性贫血 pure red cell aplasia AE MESH: D012010 a paralysis AE that shows an impairment in motor or sensory function of the lower extremities. YH, JX WEB: https://en.wikipedia.org/wiki/Paraplegia 10033892 paraplegia AE a cutaneous vasculitis AE that results in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the kin. QL, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000874.htm 皮肤变应性血管炎 allergic cutaneous vasculitis AE DO: DOID_11450 a skin hyperpigmentation AE that shows the occurrence of pigmented patches on the tongue and buccal mucousmembranes. QL, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=53725 皮肤黑斑病 melanoplakia AE SNOMEDCT: 84647002 an erythema AE that showns an erythematous eruption characterized by inflammatory nodules that are usually tender, multiple, and bilateral. Such a symptom is commonly associated with drug reactions or infection. QL, YH erythemanodosum AE WEB: https://en.wikipedia.org/wiki/Erythema_nodosum 结节性红斑 10015226 erythema nodosum AE HPO: HP_0012219 MeSH: D004893 a muscle spasm AE that occurs when the contraction of a spasm is sustained or continuing. Such a spasm is generally severe because is is often caused by diseases that affect the central nervous system or brain, such as tetanus, rabies, and cerebral palsy. QL, YH WEB: http://medical-dictionary.thefreedictionary.com/tonic+spasm 强直性痉挛 tonic spasm AE a menstrual disorder AE that results in frequent menses amd the menstrual cycles lasting less than 21 days. QL, YH 月经频繁 10070501 polymenorrhea AE HP: HP_0400007 a menstrual disorder AE that shows an outcome of a shortened time of menstrual period QL, YH short menstrual period AE WEB: http://www.everydayhealth.com/pms/short-periods.aspx 经期缩短 shortened menstrual period AE a menstrual disorder AE that shows an outcome of a prolonged duration of menstrual period QL, YH prolonged menstruation AE WEB: http://www.healthline.com/symptom/menstrual-irregularity 经期延长 prolonged menstrual period AE musculoskeletal stiffness AE that occurs at the neck and is typically characterized by soreness and difficulty moving the neck, especially when trying to turn the head to the side. QL, YH stiff neck AE WEB: http://www.spine-health.com/conditions/neck-pain/stiff-neck-causes-symptoms-and-treatment 颈项强直 10028843 neck stiffness AE stiffness of the neck AE a female reproductive system AE that occurs at the ovaries where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. QL, YH primary ovarian insufficiency AE WEB: http://www.mayoclinic.org/diseases-conditions/premature-ovarian-failure/basics/definition/con-20028351 WEB: https://www.nlm.nih.gov/medlineplus/prematureovarianfailure.html 卵巢早衰 premature ovarian failure AE DO: DOID_5426 a skin adverse event that has an outcome of a discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed. QL, YH 10040840 skin erosion AE HP: HP_0200041 a hematopoietic system AE that has an outcome of an arrest of the formation of blood cellular components. QL, YH WEB: https://en.wikipedia.org/wiki/Haematopoiesis 造血功能障碍 arrest of hematopoiesis AE an arrest of hematopoiesis AE that occurs quickly QL, YH WEB: https://en.wikipedia.org/wiki/Haematopoiesis 急性造血功能障碍 acute arrest of hematopoiesis AE an ulcer AE that occurs at the scrotum QL, YH 阴囊破溃 scrotum ulcer AE SNOMEDCT: 9750001 a skin adverse event that inherited chronic noninflammatory skin disease manifested by vesicles, large bullae (blisters), and skin erosions which often result from trauma. QL, YH epidermolysis bullosa type eruption AE WEB: http://www.mayoclinic.org/diseases-conditions/epidermolysis-bullosa/basics/definition/con-20032497 大疱性表皮坏死松解症 10014989 epidermolysis bullosa AE a female reproductive system AE that occurs in the uterus JX, YH WEB: https://en.wikipedia.org/wiki/Uterus uterine AE a reproduction system inflammation AE that occurs in the endometrium, the inner lining of the uterus. MW, YH WEB: https://en.wikipedia.org/wiki/Endometritis 子宫内膜炎 10014791 endometritis AE an inflammation AE which occurs in the female reproduction system YH, JX female reproduction system inflammation AE a reproduction system inflammation AE that occurs in the placenta. JX, YH WEB: https://en.wikipedia.org/wiki/Placenta 胎盘炎 10014791 placentitis AE a female reproductive system AE that occurs when the baby does not exit the pelvis during childbirth due to being physically blocked, even though the uterus is contracting normally. JX, YH obstructed labor AE obstructed labour AE WEB: https://en.wikipedia.org/wiki/Obstructed_labour 难产 dystocia AE a pneumonia AE that is caused by a mycotic infection JX, YH WEB: https://en.wikipedia.org/wiki/Fungal_pneumonia 真菌性肺炎 mycotic pneumonia AE an inflammation AE that refers to inflammation of the serous tissues of the body, the tissues lining the lungs (pleura), heart (pericardium), and the inner lining of the abdomen (peritoneum) and organs within. JX, YH WEB: https://en.wikipedia.org/wiki/Serositis 浆膜炎 10058556 serositis AE a female reproduction system inflammation AE that occurs in the wall of the uterus. JX, YH WEB: https://en.wikipedia.org/wiki/Metritis 子宫炎 10066270 metritis AE an abscess AE where the abscess is filled with pus. Note: based on the website: https://www.quora.com/What-is-a-purulent-abscess, it appears that the words purulent abscess are actually redundant. Purulent means pus. Abscess is a space or pocket in the body filled with pus. JX, YH 化脓性脓肿 purulent abscess AE a clostridial infection AE that results in muscle spasms. JX, YH lockjaw AE WEB: https://en.wikipedia.org/wiki/Tetanus 破伤风 10043376 tetanus AE a abscess AE that shows a collection of pus found near the rectum. JX, YH WEB: http://www.webmd.com/a-to-z-guides/anal-abscess 直肠脓肿 10048947 rectal abscess AE a brucellosis AE that shows an acute disease stage. JX, YH WEB: https://en.wikipedia.org/wiki/Brucellosis 急性布氏杆菌病 acute brucellosis AE a lymphadenopathy AE where the lymphadenopathy occurs in the supraclavicular lymph nodes. JX, YH WEB: https://en.wikipedia.org/wiki/Lymphadenopathy 锁骨上淋巴结病 supraclavicular lymphadenopathy AE a pain AE that shows a person with generalized aches and pains in multiple areas of the body. JX, YH WEB: http://www.everydayhealth.com/symptom-checker/body-aches 体痛 body ache AE an inflammation AE that occurs in the kidney tissue, calyces, and renal pelvis. JX, YH WEB: https://en.wikipedia.org/wiki/Pyelonephritis 肾盂肾炎 10037596 pyelonephritis AE a bacterial infection AE that is caused by the infection with Brucella, a Gram-negative bacterium. The infected animals can be human or a variety of mammal animals. JX, YH Bang's disease AE Crimean fever AE Gibraltar fever AE Malta fever AE Maltese fever AE Mediterranean fever AE rock fever AE undulant fever AE WEB: https://en.wikipedia.org/wiki/Brucellosis 布氏杆菌病 brucellosis AE an infection AE that is caused by a parasite. YH, JX WEB: https://en.wikipedia.org/wiki/Parasitic_disease parasitic infection AE a parasitic infection AE that is caused by a heminth, i.e., a parasitic worm, in the location of intestine. JX, YH WEB: https://en.wikipedia.org/wiki/Helminthiasis 肠道蠕虫病 intestinal helminthiasis AE a liver AE that has an outcome of the diffusion or accumulation of substances in the liver. JX, YH PubMed: http://www.ncbi.nlm.nih.gov/pubmed/20806348 WEB: https://en.wikipedia.org/wiki/Infiltration_(medical) 肝脏浸润 liver infiltration AE an epididymitis AE where the epidiymis is filled up with lymphocytes and plasma cells. JX, YH WEB: http://www.merriam-webster.com/medical/lymphoplasmacytic WEB: https://en.wikipedia.org/wiki/Epididymitis 淋巴浆细胞性附睾炎 lymphoplasmacytic epididymitis AE a testicular disorder AE that results in a discomfort or pain of the epidiymis, a curved structure at the back of the testicle in which sperm matures and is stored. JX, YH WEB: https://en.wikipedia.org/wiki/Epididymitis epididymitis AE a pneumonia AE that results in the dissemination of histiocytes in the lung. JX, YH PubMed: http://www.ncbi.nlm.nih.gov/pubmed/17882900 WEB: https://en.wikipedia.org/wiki/Pneumonia 弥漫性组织细胞性肺炎 disseminated histiocytic pneumonia AE a myocarditis AE where the heart muscle is filled with lymphocytes and plasma cells that are not normally seen. JX, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001204/ 淋巴浆细胞性心肌炎 lymphoplasmacytic myocarditis AE a syndrome AE in which the immune system begins to recover from an immunosuppression or AIDS, but then responds to a previously acquired opportunistic infection with an overwhelming inflammatory response that paradoxically makes the symptoms of infection worse. JX, YH IRIS AE immune recovery syndrome AE WEB: https://en.wikipedia.org/wiki/Immune_reconstitution_inflammatory_syndrome 10065042 immune reconstitution inflammatory syndrome AE a role that exists in a cellular and molecular interaction YH role in cellular and molecular interaction NDF-RT: N0000000223 a diarrhea AE that occurs when the bile acids are not reabsorbed into the bloodstream and enter the large bowel (colon), which causes abnormally high levels of water and salts in the large bowel and the formation of watery diarrhoea. YH bile acid malabsorption AE WEB: http://patient.info/health/bile-acid-malabsorptiondiarrhoea-leaflet WEB: https://en.wikipedia.org/wiki/Bile_acid_malabsorption WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002596/ 10069703 bile acid diarrhoea AE an adverse event that has an outcome of nutrition disorder, which can be caused by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods. YH nutrition disorder AE WEB: http://www.who.int/topics/nutrition_disorders/en/ 营养失调 nutritional disorder AE a nutrional disorder AE that has an outcome of malnutrition, a condition resulting from insufficient nutrients in the body. YH WEB: https://medlineplus.gov/ency/article/000404.htm 营养不良 malnutrition AE a gastrointestinal disorder AE that has an outcome of the presence of very large numbers of bacteria growing in the small intestine YH BLS AE BOS AE SIBO AE bacterial overgrowth syndrome AE blind loop syndrome AE small bowel bacterial overgrowth AE WEB: https://en.wikipedia.org/wiki/Blind_loop_syndrome WEB: https://medlineplus.gov/ency/article/000222.htm small intestinal bacterial overgrowth AE an edema face AE where the face has gradually swollen into a rounded shape YH WEB: http://www.webmd.com/a-to-z-guides/moon-facies moon face AE a behavioral and neurological AE that has an outcome of impaired daily self care activities. KY, YH ADL impaired AE WEB: https://en.wikipedia.org/wiki/Activities_of_daily_living 10050954 activities of daily living impaired AE a hematology investigation result abnormal AE that is characterized by an abnomalty in the antibody level in the blood YH, KY antibody test abnormal AE an antibody test abnormal AE that shows positive antinuclear antibody, which often attack a person's own cell nucleus. YH, KY ANA test abnormal AE URL: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566 In most cases, a positive ANA test indicates that your immune system has launched a misdirected attack on your own tissue — in other words, an autoimmune reaction. But some people have positive ANA tests even when they're healthy. Ref: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566 antinuclear antibody positive AE A nervous system AE which refers to an imbalance problem in the part of the nervous system that controls involuntary actions KY, YH https://medlineplus.gov/autonomicnervoussystemdisorders.html#cat59 10003840 autonomic nervous system imbalance AE A CSF test result abnormal AE with high glucose levels in the cerebrospinal fluid. KY, YH https://en.wikipedia.org/wiki/CSF_glucose 10050763 CSF glucose increased AE A CSF test result abnormal AE with high immunoglobin levels in the cerebrospinal fluid. KY, YH https://labtestsonline.org/understanding/conditions/multiplesclerosis/start/2/ 10064338 CSF immunoglobulin increased AE A palsy AE with temporary or permanent weakness of the facial muscles on one or both sides of the face. KY, YH http://www.facialpalsy.org.uk/about-facial-palsy/what-is-facial-palsy/1395/ 10016060 facial palsy AE A bone AE that refers to structural failure in a disc and advanced signs of aging. KY, YH https://www.ncbi.nlm.nih.gov/pubmed/16915105 10061246 intervertebral disc degeneration AE A behavioral and neurological test abnormal AE result that has an abnormal outcome in lumbar puncture involving pain or numbness to the legs, lower back pain, headaches, risk of infection, or risk of bleeding in the spinal canal. KY, YH http://www.hopkinsmedicine.org/healthlibrary/test_procedures/neurological/lumbar_puncture_lp_92,p07666/ 10025000 lumbar puncture abnormal AE A paralysis AE accompanied by involuntary tremors. KY, YH WEB: https://en.oxforddictionaries.com/definition/palsy WEB: https://en.wikipedia.org/wiki/Palsy 麻痹 palsy AE A behavioral and neurological test abnormal AE that involves an abnormal outcome in the series of simple questions and noninvasive tests in a neurological examination that provides crucial information about the nervous system. KY, YH http://www.healthcommunities.com/brain-nerve-tests/what-is-a-neuro-exam.shtml 10056832 neurological examination abnormal AE A paralysis AE characterized by extreme muscle weakness and loss of muscle tone. KY, YH http://www.brainandspinalcord.org/flaccid-paralysis/ 弛缓性麻痹 10033809 paralysis flaccid AE A paralysis AE on the peroneal nerve leading to loss of movement or sensation on the foot and leg and may lead to complete weakness or paralysis of the foot or leg. KY, YH https://medlineplus.gov/ency/article/000791.htm 10034701 peroneal nerve palsy AE A hyperaesthesia AE that occurs at the optic area, reflected by an abnormal sensitivity to light. YH, Jiahao Wang WEB: http://medical-dictionary.thefreedictionary.com/optic+hyperesthesia 光过敏 optic hyperesthesia AE An abnormal respiration AE that shows a severely deficient supply of oxygen to the body that arises from abnormal breathing. YH, Jiahao Wang asphyxiation AE WEB: https://en.wikipedia.org/wiki/Asphyxia 窒息 10003497 10003502 asphyxia AE An muscle AE showing delayed relaxation (prolonged contraction) of the skeletal muscles after voluntary contraction or electrical stimulation YH, Jiahao Wang WEB: https://en.wikipedia.org/wiki/Myotonia 肌强直 10061533 myotonia AE An myotonia AE that occurs in the neck. YH, Jiahao Wang WEB: https://en.wikipedia.org/wiki/Myotonia 颈项强直 neck myotonia AE a behavioral and neurological AE that refers to any pain or discomfort in the abdomen. NG, YH https://en.wikipedia.org/wiki/Distress_(medicine) 10000062 abdominal distress AE A blindness AE that refers to the reduced ability to distinguish between colors that are obvious to the rest of the population NG, YH https://en.wikipedia.org/wiki/Color_blindness 10010016 color blindness AE a behavioral and neurological AE that is characterized by involuntary muscle contractions that cause abnormal posture and slow, repetitive movements NG, YH http://www.webmd.com/brain/dystonia-causes-types-symptoms-and-treatments#1 10013983 dystonia AE a behavioral and neurological AE that is characterized by potentially impulsive or poorly controlled activity NG, YH 10015627 exciteness AE a dizziness AE that creates a feeling of a light head caused by a temporary decrease in blood to the brain NG, YH https://en.wikipedia.org/wiki/Lightheadedness 10024492 lightheadedness AE a psychiatric disorder AE that is characterized by an elevation or lowering of a person's mood NG, YH mood problem https://en.wikipedia.org/wiki/Mood_disorder 10027952 mood disorder AE a menstrual disorder AE that is characterized by infrequent menstrual periods NG, YH https://en.wikipedia.org/wiki/Oligomenorrhea 10030294 oligomenorrhea AE an ear AE that refers to ear poisoning resulting from exposure to drugs or chemicals that damage the inner ear NG, YH https://en.wikipedia.org/wiki/Ototoxicity 10033109 ototoxicity AE an inflammation AE that leads to swelling around the blood vessel wall NG, YH http://medical-dictionary.thefreedictionary.com/periarteritis 10034462 periarteritis AE a tumor AE that is benign and characterized by a small wart-like growth on the skin NG, YH https://en.wikipedia.org/wiki/Papilloma 10033722 skin papilloma AE a paresthesia AE characterized by unusual prickling sensations in any part of the body NG, YH http://www.mayoclinic.org/symptom-checker/numbness-or-tingling-in-hands-adult/related-factors/itt-20009075 10043876 tingling AE a diarrhea AE that has 4 stools per day over baseline; mild increase in ostomy output compared to baseline. MW, EO Grade 1 diarrhea AE CTCAE: E10573 a diarrhea AE that has increased of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline. MW, EO Grade 2 diarrhea AE CTCAE: E10574 a diarrhea AE that has increased of >=7 stools per day over baseline; incontinence; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL MW, EO Grade 3 diarrhea AE CTCAE: E10575 An epileptic seizure AE that is a complex autosomal dominant disorder usually caused by mutations in SCN1A (a voltage-gated sodium channel). One third of patients have febrile seizures only; two thirds have a variety of epilepsy syndromes, both focal and generalized. GEFS+ AE https://www.ncbi.nlm.nih.gov/pubmed/25917466 BY, YH genetic epilepsy with febrile seizures plus AE MW, EO a nausea AE that has Loss of appetite without alteration in eating habits Grade 1 nausea AE CTCAE: E10879 MW, EO a nausea AE that has oral intake decreased without significant weight loss, dehydration or malnutrition Grade 2 nausea AE CTCAE: E10880 MW, EO a nausea AE that has inadequate oral caloric or fluid intake; tube feeding, TPN, or hospitalization indicated Grade 3 nausea AE CTCAE: E10881 A bacterial infection AE that is induced by the bacterium Bordetella pertussis, which causes an acute respiratory infection marked by severe, spasmodic coughing episodes during the paroxysmal phase. https://www.ncbi.nlm.nih.gov/books/NBK7813/ BY, YH Bordetella pertussis infection AE A thyroiditis AE that is caused by an infection with a pathogen (e.g., bacterium or virus). YH https://en.wikipedia.org/wiki/Thyroiditis 10071250 infectious thyroiditis AE A disorder material entity that forms an open sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. YH https://en.wikipedia.org/wiki/Ulcer ulcer A neurotoxicity that occurs at the central nervous system. This type of neurotoxity manifests as altered thought content resulting in psychosis or confusion. BY, YH https://www.ncbi.nlm.nih.gov/pubmed/24275175 10071215 central nervous system toxicity AE A paralysis AE that results from infection with any one of the three related poliovirus types (referred to as types P1, P2, and P3) and that attacks the body's nervous system. infantile paralysis AE polio AE http://www.who.int/biologicals/areas/vaccines/polio/en/ 10036012 BY, YH poliomyelitis AE An immune system AE where a transplant recipient's immune system attacks the transplanted organ or tissue. transplant rejection AE https://medlineplus.gov/ency/article/000815.htm 10018650 BY, YH graft rejection AE A vasculitis AE that affects medium-sized and small muscular arteries, resulting in microaneurysm formation, aneurysmal rupture with hemorrhage, thrombosis, and, consequently, organ ischemia or infarction. panarteritis nodosa AE polyarteritis nodosa AE http://emedicine.medscape.com/article/330717-overview 10034462 BY, YH periarteritis nodosa AE An abnormal reflex AE characterized by episodes of shaking or exaggerated shivering which can occur with a high fever. http://patient.info/doctor/rigors 10039177 BY, YH rigors AE An immunology AE in which cells of the lymphatic system grow excessively. It is a AE of the lymphoid cells and of cells from the reticuloendothelial system that usually occur in people with compromised immune systems. http://www.medicinenet.com/script/main/art.asp?articlekey=7859 10061232 BY. YH lymphoproliferative disorder AE A rash AE where the rash is present on only one area of the body, which is usually caused by cellulitis, contat dermatitis, and poison ivy. http://www.everydayhealth.com/symptom-checker/localized-rash 10062705 BY, YH localized rash AE A neuropathy AE that is characterized by recurrent episodes of numbness, tingling, and loss of muscle function in the region associated with the affected nerve, usually an arm, hand, leg, or foot. HNPP AE https://ghr.nlm.nih.gov/condition/hereditary-neuropathy-with-liability-to-pressure-palsies 10069382 BY, YH hereditary neuropathy with liability to pressure palsies AE A viral infection AE that is caused by a Rubella virus. This contagious AE leads to symptoms that can include a low-grade fever, sore throat, and a red rash that starts on the face and spreads to the rest of the body. german measles AE three-day measles AE http://bodyandhealth.canada.com/channel/childhood-vaccinations/related-conditions/rubella 10018206 BY, YH Rubella infection AE A poliomyelitis AE that is associated with oral poliovirus vaccine (OPV) that occurs among healthy OPV recipients and their contacts. It is clinically indistinguishable from poliomyelitis caused by wild-type polio virus, which causes temporary or permanent paralysis. VAPP AE https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321898/ 10076716 BY, YH vaccine-associated paralytic poliomyelitis AE A seizure AE that is a rare, catastrophic, lifelong form of epilepsy that begins in the first year of life with frequent and/or prolonged seizures. SMEI AE dravet syndrome AE https://www.dravetfoundation.org/what-is-dravet-syndrome/ 10073677 BY, YH severe myoclonic epilepsy of infancy AE A bacterial infection AE that is caused by exposure to environmental sources of nontuberculous mycobacteria (NTM), which leads to NTM entering the lungs, causing inflammation in the respiratory system. This AE can lead to progressive lung infection characterized by cough, shortness of breath, fatigue, and weight loss. NTM infection AE http://www.lung.org/lung-health-and-diseases/lung-disease-lookup/nontuberculosis-mycobacteria/learn-about-ntm.html BY. YH nontuberculous mycobacteria infection AE An immunodeficiency AE that affects the immune system and results in the lack of the ability for the body to generate mature B cells, which manifests as a complete or near-complete lack of proteins called gamma globulins, including antibodies, in their bloodstream. This AE occurs almost exclusively in males. This AE also increases susceptibility to infections. Bruton’s Agammaglobulinemia AE Congenital Agammaglobulinemia AE XLA AE http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/agammaglobulinemia-x-linked-autosomal-recessive/ https://en.wikipedia.org/wiki/X-linked_agammaglobulinemia https://ghr.nlm.nih.gov/condition/x-linked-agammaglobulinemia BY. YH X-linked agammaglobulinemia AE A multi-organ failure AE that is associated with administration of a Yellow Fever vaccine. This happens when vaccine virus proliferates in multiple organs, causing multiple organ dysfunction syndrome or multiorgan failure and death. https://www.cdc.gov/travel-training/local/HistoryEpidemiologyandVaccination/page27412.html 10069197 BY, YH Yellow Fever vaccine-associated viscerotropic disease AE A duodenal ulcer AE that alters GI function and requiresTPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL. Grade 3 duodenal ulcer AE CTCAE: E10614 An anus AE that bleed from the anal region. 10055226 anal hemorrhage AE CTCAE: E10470 NCIt: C78168 An anal hemorrhage AE that has moderate symptoms; medical intervention or minor cauterization indicated. Grade 2 anal hemorrhage AE CTCAE: E10472 A thyroiditis AE where the thyroiditis inflammation has an acute process. YH https://en.wikipedia.org/wiki/Thyroiditis 10043780 acute thyroiditis AE An anal hemorrhage AE that has transfusion, radiologic, endoscopic, or elective operative intervention indicated. Grade 3 anal hemorrhage AE CTCAE: E10473 A gastrointestinal disorder AE that has a narrowing of the lumen of the colon. 10010004 colonic stenosis AE CTCAE: E10550 NCIt: C78243 A colonic stenosis AE that altered GI function. Grade 2 colonic stenosis AE CTCAE: E10552 A colonic stenosis AE that alters GI function and requires tube feeding or hospitalization. Grade 3 colonic stenosis AE CTCAE: E10553 An esophagus AE that has a rupture in the wall of the esophagus. 10055472 esophageal perforation AE CTCAE: E10665 NCIt: C50693 A mucosal inflammation AE that has moderate pain which is not interfering with oral intake but modified diet indicated. Grade 2 mucosal inflammation AE CTCAE: E10874 A mucosal inflammation AE that is interfering with oral intake. Grade 3 mucosal inflammation AE CTCAE: E10875 A dysesthesia AE that has burning or tingling sensation on the lips, tongue or entire mouth. 10054520 oral dysesthesia AE CTCAE: E10894 NCIt: C62545 An oral dysesthesia AE that has disabling pain, requires tube feeding and TPN. Grade 3 Oral dysesthesia AE CTCAE: E10897 An oral dysesthesia AE that has m oderate pain and is interfering with oral intake. Grade 2 Oral dysesthesia AE CTCAE: E10896 An oral dysesthesia AE that has mild discomfort but is not interfering with oral intake. Grade 1 Oral dysesthesia AE CTCAE: E10895 A periodontal disease AE that has spontaneous bleeding, severe bone loss with or without tooth loss and osteonecrosis of maxilla or mandible. Grade 3 periodontal disease AE CTCAE: E10938 A periodontal disease AE that has moderate gingival recession or gingivitis, multiple sites of bleeding on probing and moderate bone loss. Grade 2 periodontal disease AE CTCAE: E10937 A periodontal disease AE that has gingival recession or gingivitis, limited bleeding on probing and mild local bone loss. Grade 1 periodontal disease AE CTCAE: E10936 A necrosis AE that there the ecrotic process occurring in the rectal wall. 10065709 rectal necrosis AE CTCAE: E10967 NCIt: C78585 A rectal necrosis AE that requires tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated. Grade 3 rectal necrosis AE CTCAE: E10968 An inflammation AE that has inflammation of the salivary duct. 10056681 salivary duct inflammation AE CTCAE: E10470 NCIt: C78600 A salivary duct inflammation AE that has acute salivary gland necrosis; severe secretion-induced symptoms (e.g., thick saliva/oral secretions or gagging); tube feeding or TPN indicated; limiting self care ADL; disabling Grade 3 salivary duct inflammation AE CTCAE: E11006 A salivary duct inflammation AE that has thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL Grade 2 salivary duct inflammation AE CTCAE: E11005 A salivary duct inflammation AE that has slightly thickened saliva; slightly altered taste (e.g., metallic) Grade 1 salivary duct inflammation AE CTCAE: E11004 An inflammation AE that has inflammation of the mucous membrane of the small intestine. 10065710 small intestinal mucositis AE CTCAE: E11015 NCIt: C78613 A small intestinal mucositis AE that has severe pain and is interfering with oral intake; tube feeding, TPN or hospitalization indicated. Grade 3 small intestinal mucositis AE CTCAE: E11018 A small intestine ulcer AE that has altered GI function, requires TPN indicated. Elective operative or endoscopic intervention indicated; limiting self care ADL; disablingoperative intervention Grade 3 small intestine ulcer AE CTCAE: E11041 A small intestine ulcer AE that has altered GI function. Grade 2 small intestine ulcer AE CTCAE: E11040 A tooth disorder AE that has a pathological process of the teeth occurring during tooth development. 10044030 tooth development disorder AE CTCAE: E11048 NCIt: C35596 A tooth development disorder AE that has maldevelopment with impairment not surgically correctable. Grade 3 tooth development disorder AE CTCAE: E11051 A tooth development disorder AE that has impairment correctable with oral surgery Grade 2 tooth development disorder AE CTCAE: E11050 A tooth development disorder AE that has hypoplasia of tooth or enamel. Grade 1 tooth development disorder AE CTCAE: E11049 A digestive system AE that has abdominal pain, fever, change in bowel habits with ileus and peritoneal signs. Grade 3 cecitis AE CTCAE: E11059 A thyroiditis AE where the thyroiditis inflammation has a chronic process. YH https://en.wikipedia.org/wiki/Thyroiditis 10043781 chronic thyroiditis AE A chronic thyroiditis AE that shows a lot of dense fibrous tissue. YH Riedel goiter AE Riedel's thyroiditis AE chronic sclerosing thyroiditis AE chronic thyroiditis wood AE fibrous chronic thyroiditis AE invasive fibrous thyroiditis AE http://www.healthfrom.com/Disease/view-3435.html 10043782 chronic fibrous thyroiditis AE An acute thyroiditis AE that shows a form of painful, acute thyroiditis resulting from radioactive therapy to treat hyperthyroidism or from radiation to treat head and neck cancer or lymphoma. YH https://en.wikipedia.org/wiki/Radiation-induced_thyroiditis 10063885 radition thyroiditis AE An autoimmune thyroiditis AE where the thyroid gland is gradually destroyed. JX, YH Hashimoto's disease AE chronic lymphocytic thyroiditis AE https://en.wikipedia.org/wiki/Autoimmune_thyroiditis 10069432 Hashimoto's thyroiditis AE An autoimmune thyroiditis AE that shows an organ-specific autoimmune disease characterized by thyroid autoantibodies, functional hypothyroidism, and absence of goiter. YH https://link.springer.com/chapter/10.1007%2F978-1-60327-285-8_42 10077172 atrophic thyroiditis AE A thyroiditis AE that occurs after pregnancy and may involve hyperthyroidism, hypothyroidism or the two sequentially. YH https://en.wikipedia.org/wiki/Postpartum_thyroiditis postpartum thyroiditis AE An adverse event of hematoma in the subcapsular space of the kidney. This event occurs after a medical intervention, and may be caused by a tumor, trauma, vasculitis, renal infarction, or other disease process. YH, EO https://medical-dictionary.thefreedictionary.com/subcapsular+hematoma subcapsular hematoma subcapsular hematoma AE An adverse event of hematoma occurring around the kidney. YH, EO perinephric hematoma perinephric hematoma AE YH, EO arteriovenous fistulae arteriovenous fistula arteriovenous fistula AE An adverse event of surgery that leads to the puncturing of an adjacent organ. For example, a needle to the kidney may puncture the adjacent organs. Jennifer Schaub, Oliver He puncturing of adjacent organs https://www.ncbi.nlm.nih.gov/books/NBK493205/ puncturing of adjacent organ AE A renal failure AE that is characterized by abnormally high levels of nitrogen-containing compounds (such as urea, creatinine, various body waste compounds, and other nitrogen-rich compounds) in the blood. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Azotemia 10003885 azotaemia AE An adverse event with the IgA nephropathy, a form of glomerulonephritis (an inflammation of the glomeruli of the kidney), primarily characterized by deposition of the IgA antibody in the glomerulus. YH Berger's disease IgA nephritis IgAN synpharyngitic glomerulonephritis https://en.wikipedia.org/wiki/IgA_nephropathy IgA nephropathy AE An adverse event with the IgM nephropathy, a form of glomerulonephritis (an inflammation of the glomeruli of the kidney), primarily characterized by deposition of the IgM antibody in the glomerulus. YH https://nephcure.org/livingwithkidneydisease/understanding-glomerular-disease/other-glomerular-diseases/igm-nephropathy/ IgM nephropathy AE A urine abnormality AE that is characterized by dark colored urine resulting from abormally high blood levels of conjugated bilirubin. David Ameriguian, Oliver He https://meded.ucsd.edu/clinicalimg/genital_urine_bili.htm 10004710 bilirubinuria AE A bladder cancer AE that is characterized by a benign or malignant, primary or metastatic neoplasm of the bladder. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/medgen/594 10005056 bladder neoplasm AE A urine abnormality AE that is characterized by the presence of bile in urine. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Choluria 10008684 choluria AE A urine abnormality AE that is characterized by when one passes blood sugar (blood glucose) into urine. David Ameriguian, Oliver He https://www.healthline.com/healthy/glycosuria 10018473 glycosuria AE A urine abnormality AE that is characterized by an abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/publications/dictionaries/cancer-terms/def/hydroureter 10021096 hyposthenuria AE A urine abnormality AE that is characterized by a medical condition in which ketone bodies are present in the urine. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Ketonuria 10023388 ketonuria AE A urine abnormality AE that is characterized by an abnormal pathologic state in which an excessive amount of myoglobin is found in the urine, imparting a cola-like hue, usually in association with myonecrosis and a clinical picture of weakness, myalgias, edema. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/pubmed/10658177 10028629 myoglobinuria AE The date time when an adverse event starts YH adverse event start date A kidney AE that is characterized by disease or damage of the kidney, which can eventually result in kidney failure David Ameriguian, Oliver He https://www.news-medical.net/health/What-is-Nephropathy.aspx 10029151 nephropathy AE A nephropathy AE that is characterized by any adverse functional or structural changes in the kidney due to the effect of a chemical or biological product that is inhaled, ingested, injected, or otherwise absorbed, or that yields toxic metabolites with an identifiable adverse effect on the kidneys. David Ameriguian, Oliver He https://jamanetwork.com/journals/jama/fullarticle/655056 10029155 nephropathy toxic AE A congenital AE that is characterized by a birth defect and inherited condition that affects the urinary tract (kidneys, ureters, and bladder) or the genital tract (reproductive organs). David Ameriguian, Oliver He https://umiamihealth.org/treatments-and-services/nephrology/congenital-urogenital-abnormalities 10062334 congenital genitourinary abnormality AE A urinary system AE that is characterized by the abnormal enlargement of the ureter caused by any blockage that prevents urine from draining into the bladder. David Ameriguian, Oliver He https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hydroureter 10020533 hydroureter AE A urinary system AE that is characterized by a condition in which the nephrons, the functional units of the kidneys, become inflamed. David Ameriguian, Oliver He https://www.medicalnewstoday.com/articles/312579.php 10029117 nephritis AE A kidney AE that is characterized by a progressive disease of the kidneys that results from sclerosis (hardening) of the small blood vessels in the kidneys. David Ameriguian, Oliver He https://www.medicinenet.com/script/main/art.asp?articlekey=4533 10029159 nephrosclerosis AE The date time when an adverse event ends YH adverse event end date an adverse event reporting that is to report an adverse event in an expedited time frame. YH AE expedited reporting adverse event expedited reporting https://www.niaid.nih.gov/sites/default/files/eaereportpolicy.pdf expedited adverse event reporting A pain AE that is characterized by pain from disease or injury to a kidney David Ameriguian, Oliver He kidney pain AE https://www.mayoclinic.org/symptoms/kidney-pain/basics/definition/sym-20050902 10039490 renal pain AE A kidney AE that is characterized by a very heterogeneous group of hereditary and acquired diseases that involve singular or complex dysfunctions of transporters and channels in the renal tubular system David Ameriguian, Oliver He https://www.amboss.com/us/knowledge/Renal_tubular_disorders 10038537 renal tubular disorder AE A renal tubular disorder AE that is characterized by acute kidney injury in the renal category involving damage to the tubule cells of the kidneys, which can lead to acute kidney failure David Ameriguian, Oliver He https://medlineplus.gov/ency/article/000512.htm 10038540 renal tubular necrosis AE A kidney AE that is characterized by vessel wall leukocyte infiltration, often with necrosis affecting the kidney David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/pubmed/19891303 10038546 renal vasculitis AE A urinary system AE that is characterized by when a person has trouble starting or maintaining a urine stream David Ameriguian, Oliver He https://www.medicalnewstoday.com/articles/321087.php 10046542 urinary hesitation AE A urinary system AE that is characterized by any disorder that affects your urinary tract, which is the body's drainage system for removing urine David Ameriguian, Oliver He https://www.niddk.nih.gov/health-information/urologic-diseases 10046566 urinary tract disorder AE A uninary system AE that occurs in bladder David Ameriguian, Oliver He bladder disorder AE 10005037 10056655 bladder AE A urine abnormality AE that is characterized by the presence of porphyrins in the urine David Ameriguian, Oliver He https://en.wiktionary.org/wiki/porphyrinuria 10036193 porphyrinuria AE An abscess AE that is characterized by an infection that has gotten into the kidneys caused by bacteria. David Ameriguian, Oliver He https://www.urologyhealth.org/urologic-conditions/kidney-(renal)-abscess 10038351 renal abscess AE A kidney AE that is characterized by a kidney disorder where the kidneys are relatively small in comparison to the gender, age, and body weight of the patient. David Ameriguian, Oliver He https://www.novusbio.com/diseases/congenital-renal-atrophy 10038381 renal atrophy AE A kidney AE that is characterized by a sac of fluid that forms in the kidney. David Ameriguian, Oliver He https://www.radiologyinfo.org/en/info.cfm?pg=renal-cyst 10038423 renal cyst AE A bladder AE that is characterized by complete absence, or agenesis, of the urinary bladder David Ameriguian, Oliver He https://jamanetwork.com/journals/jama/fullarticle/325825 10056655 bladder agenesis AE A bladder AE that is characterized by a pouch in the bladder wall that a person may either be born with or get later. David Ameriguian, Oliver He https://www.urologyhealth.org/urologic-conditions/bladder-diverticulum 10005038 bladder diverticulum AE A bladder AE that is characterized by scarring and hardening of the tissue in the bladder. David Ameriguian, Oliver He https://www.oncolink.org/support/side-effects/genitourinary-side-effects/bladder-fibrosis 10005042 bladder fibrosis AE A bladder AE that is characterized by tumor-like formations, projecting above the level of the mucous membrane of the efferent urinary passages, and consisting of granulation tissue. David Ameriguian, Oliver He https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1464-410X.1937.tb06608.x 10005043 bladder granuloma AE A bladder AE that is characterized by an enlarged bladder where the bladder walls become thicker and then grow because they are overstretched. David Ameriguian, Oliver He enlarged bladder AE https://www.healthline.com/health/enlarged-bladder 10063408 bladder hypertrophy AE A bladder AE that is characterized by external bladder injuries that are caused by either blunt or penetrating trauma to the lower abdomen, pelvis, or perineum. David Ameriguian, Oliver He https://www.merckmanuals.com/professional/injuries-poisoning/genitourinary-tract-trauma/bladder-trauma 10061698 bladder injury AE A bladder AE that is characterized by squamous metaplasia of the transitional epithelium and keratinization; it is a rare condition. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/pubmed/1949238 10051257 bladder leukoplakia AE A bladder AE that is characterized by acute or chronic changes in the uterine shape or position; this can occur in women prior to labor, during labor, or postpartum. David Ameriguian, Oliver He https://emedicine.medscape.com/article/272497-overview 10049716 bladder malposition acquired AE A bladder AE that is characterized by an overly distended bladder with flattened urothelium. David Ameriguian, Oliver He https://ntp.niehs.nih.gov/nnl/urinary/urinary_bladder/dilation/urinary_bladder-dilation_508.pdf 10005033 bladder dilatation AE A bladder AE that is characterized by being the putative precursor of urothelial carcinoma in situ (CIS) and invasive urothelial carcinoma of the urinary tract. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/pubmed/10199474 10069448 bladder dysplasia AE A bladder AE that is characterized by a number of urinary conditions in people who lack bladder control due to a brain, spinal cord, or nerve problem. David Ameriguian, Oliver He https://www.urologyhealth.org/urologic-conditions/neurogenic-bladder 10029279 neurogenic bladder AE A urinary system AE that is characterized by a problem that affects the urinary and genital tracts (reproductive organs) This term may need to move to a higher level. More work need to be done. David Ameriguian, Oliver He https://intermountainhealthcare.org/services/pediatrics/services/urology/urogenital-disorders/ 10046694 urogenital disorder AE A procedural complication AE that occurs after a blood transfusion YH blood transfusion reaction AE A kidney AE that is characterized by a reversible form of acute renal dysfunction; it encompasses several different conditions that vary considerably. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895370/ 10001017 acute prerenal failure AE A urinary system AE that is characterized by an abnormal amount of amino acids in the urine. David Ameriguian, Oliver He https://www.ucsfbenioffchildrens.org/tests/003366.html 10001939 aminoaciduria AE A congenital AE that is characterized by a wide range of kidney disease that are from birth; cystic disease may involve one or both kidneys and may or may not occur in the presence of other anomalies. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Cystic_kidney_disease 10010428 congenital cystic kidney disease AE A bladder AE that is characterized by a bladder whose muscles do not fully contract. This makes it hard to urinate. David Ameriguian, Oliver He flaccid bladder, acontracile bladder https://www.healthline.com/health/atonic-bladder 10003629 atonic urinary bladder AE A kidney AE that is characterized by a disease that causes abnormal blood clots to form in small blood vessels in the kidneys. David Ameriguian, Oliver He atypical hemolytic uremic syndrome https://rarediseases.info.nih.gov/diseases/8702/atypical-hemolytic-uremic-syndrome 10079840 atypical haemolytic uraemic syndrome AE A urinary tract infection AE that is characterized by a type of urinary tract infection caused by bacteria where one or both kidneys become infected. David Ameriguian, Oliver He https://www.urologyhealth.org/urologic-conditions/kidney-(renal)-infection-pyelonephritis 10059517 bacterial pyelonephritis AE A urinary system AE that is characterized by the presence of bacteria in urine. It is often accompanied by symptoms is a urinary tract infection while that without is known as asymptomatic bacteriuria. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Bacteriuria 10004056 bacteriuria AE A bladder neoplasm AE that is characterized by a non-cancerous tumor of the bladder that does not spread (metastasize) to other parts of the body. David Ameriguian, Oliver He http://www.cancer.ca/en/cancer-information/cancer-type/bladder/bladder-cancer/non-cancerous-tumours/?region=on 10004302 benign neoplasm of bladder AE A bladder cancer AE that is characterized by cancer that has returned following initial treatment with surgery, radiation, chemotherapy, and immunotherapy. recurrent bladder cancer https://www.texasoncology.com/types-of-cancer/bladder-cancer/recurrent-bladder-cancer 10005005 bladder cancer recurrent AE A bladder AE that is characterized by problems with urination. This may include urgency of urination, frequency of urination, ability to "hold" urine during day or night, urinary incontinence, infrequent voiding, constipation, or other diagnoses. David Ameriguian, Oliver He https://www.choc.org/programs-services/urology/dysfunctional-bladder/ 10069632 bladder dysfunction AE A bladder AE that is characterized by a blockage at the base or neck of the bladder. Such a blockage reduces or stops the flow of urine into the urethra, which carries urine from the body. David Ameriguian, Oliver He https://my.clevelandclinic.org/health/diseases/15181-bladder-outlet-obstruction- 10005060 bladder obstruction AE A bladder AE that is characterized by a narrowing that can cause bladder obstruction that leads to incomplete bladder emptying. David Ameriguian, Oliver He https://urobop.co.nz/our-services/id/62 10005082 bladder stenosis AE A bladder cancer AE that is characterized by cancer that starts in the urothelial cells that line the inside of the bladder. It is the most common type of bladder cancer. David Ameriguian, Oliver He urothelial carcinoma https://www.cancer.org/cancer/bladder-cancer/about/what-is-bladder-cancer.html 10005084 bladder transitional cell carcinoma AE A urinary system AE that is characterized by yeast in the urine which can range from procurement contamination to a sign of a life-threatening, opportunistic fungal infection. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/pubmed/11095903 10050762 candiduria AE A bladder AE that is characterized by a severe and long-standing reduction in bladder capacity. David Ameriguian, Oliver He https://www.auajournals.org/article/S0022-5347(17)70833-6/pdf 10010814 contracted bladder AE A kidney AE that is characterized by a medical test in which pain is elicited by percussion of the area of the back overlying the kidney (the costovertebral angle, an angle made by the vertebral column and the costal margin). David Ameriguian, Oliver He CVA tenderness, Murphy's punch sign, Pasternacki's sign, Goldflam's sign https://en.wikipedia.org/wiki/Costovertebral _angle_tenderness costovertebral angle tenderness AE A kidney AE that is characterized by a major shock and renal failure after a crushing injury to skeletal muscle. David Ameriguian, Oliver He Traumatic rhabdomyolysis, Bywaters' syndrome https://en.wikipedia.org/wiki/Crush_syndrome 10050702 crush syndrome AE A urinary system AE thta is characterized by cloudy urine when the cause of cloudiness is due to crystals found in the urine when performing a urine test. It is considered often as a benign condition. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Crystalluria 10011509 crystalluria AE A cystitis AE that is characterized by a strong, persistent urge to urinate; a burning sensation when urinating; passing ferquent, small amounts of urine; blood in the urine (hematuria); passing cloudy or strong-smelling urine; pelvic discomfort; a feeling of pressure in the lower abdomen; and a low-grade fever. David Ameriguian, Oliver He https://ww.mayoclinic.org/diseases-conditions/cystits/symptoms-causes/syc-20371306 10050687 cystitis-like symptom AE A kidney AE that is characterized by a birth defect in which a kidney is located below, above, or on the opposite side of its usual position; about one in 900 people has an ectopic kidney. David Ameriguian, Oliver He https://www.niddk.nih.gov/health-information/kidney-disease/children/ectopic-kidney 10063044 ectopic kidney AE A kidney AE that is characterized by two ureters coming from a single kidney. David Ameriguian, Oliver He https://www.chop.edu/conditions-diseases/duplex-kidney 10023416 kidney duplex AE A kidney AE that is characterized by a mixed bag of developmental abberations, all of which involve anatomical or major structural anomalies. David Ameriguian, Oliver He https://adc.bmj.com/content/77/6/471 10023430 kidney malformation AE A kidney AE that is characterized by either partial or complete fusion of the two kidneys. David Ameriguian, Oliver He https://www.omicsonline.org/open-access/renal-fusion-anomalies-a-review-of-surgical-anatomy-2161-0940-S5-001.php?aid=57809 10068033 renal fusion anomaly AE A urinary system AE that is characterized by either an anterior or posterior situation; the second type is the most common obstructive congenital malformation of the urethra. The condition presents with abnormal posterior urethral folds or membranes that prevent urine evacuation from the bladder. David Ameriguian, Oliver He https://www.sciencedirect.com/topics/medicine-and-dentistry/urethral-valves 10046479 urethral valves AE A bladder AE that is characterized by the urodynamic description of bladder outlet obstruction from detrusor muscle contraction with concomitant involuntary urethral sphincter activation. David Ameriguian, Oliver He https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739973 10012660 detrusor sphincter dyssynergia AE A kidney AE that is characterized by the most advanced stage of kidney disease. David Ameriguian, Oliver He https://www.heart.org/en/health-topics/diabetes/why-diabetes-matters/kidney-disease--diabetes 10012660 diabetic end stage renal disease AE A kidney AE that is characterized by a serious kidney-related complication of type 1 diabetes and type 2 diabetes. David Ameriguian, Oliver He diabetic kidney disease https://www.mayoclinic.org/diseases-conditions/diabetic-nephropathy/symptoms-causes/syc-20354556 10061835 diabetic nephropathy AE A kidney AE that is characterized by a rare disease that attacks the kidney's filtering units (glomeruli) causing serious scarring which leads to permanent kidney damage and even failure. David Ameriguian, Oliver He https://nephcure.org/livingwithkidneydisease/understanding-glomerular-disease/understanding-fsgs/ 10067757 focal segmental glomerulosclerosis AE A urinary system AE that is characterized by urinary retention in young women; the problem is caused by the sphincter's failure to relax to allow urine to be passed. David Ameriguian, Oliver He https://www.bladderandbowel.org/bladder/bladder-conditions-and-symptoms/fowlers-syndrome/ 10071718 fowler's syndrome AE A urinary system AE that is characterized by any symptom related to the urinary and genital organs. David Ameriguian, Oliver He https://www.stanfordchildrens.org/en/topic/default?id=overview-of-genitourinary-disorders-90-P03103 10075537 genitourinary symptom AE A kidney AE that is characterized by inflammation and subsequent damage of the glomeruli leading to hematuria, proteinuria, and azotemia; it may be caused by primary renal disease or systemic conditions. Acute glomerulonephritis is the third most common cause of end-stage renal disease. David Ameriguian, Oliver He https://emedicine.medscape.com/article/777272-overview 10018366 glomerulonephritis acute AE A kidney AE that is characterized by glomerulonephritis that develops silently (without symptoms) over several years, leading, often, to complete kidney failure. David Ameriguian, Oliver He https://www.kidney.org/atoz/content/glomerul 10018367 glomerulonephritis chronic AE A kidney AE that is characterized by a type of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basement membrane thickening. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Membranoproliferative_glomerulonephritis 10018370 glomerulonephritis membranoproliferative AE A kidney AE that is characterized by a specific type of glomerulonephritis that develops when inflammation of your kidney structures causes problems with the functioning of your kidney. David Ameriguian, Oliver He https://www.healthline.com/health/membranous-nephropathy 10018372 glomerulonephritis membranous AE A kidney AE that is characterized by a disease affecting the kidneys which causes a nephrotic syndrome. David Ameriguian, Oliver He minimal change disease https://en.wikipedia.org/wiki/Minimal_change_disease 10018374 glomerulonephritis minimal lesion AE A kidney AE that is characterized by an increased number of cells in the glomerulus. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Glomerulonephritis 10018376 glomerulonephritis proliferative AE A kidney AE that is characterized by any disease of renal glomeruli. David Ameriguian, Oliver He 10018620 glomerulonephropathy AE An autoimmune disorder AE that is characterized by a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure. David Ameriguian, Oliver He goodpasture syndrome https://en.wikipedia.org/wiki/Goodpasture_syndrome 10018620 goodpasture's syndrome AE A urinary system AE that is characterized by bleeding of the urinary tract that can happen without a clear cause or as a result of an injury. David Ameriguian, Oliver He hemorrhage urinary tract https://www.hog.org/handbook/article/3/33/urinary-tract-bleeds 10055847 haemorrhage urinary tract AE A kidney AE that is characterized by a rare kidney disease leading to chronic kidney disease in a non-negligible percentage of patients. David Ameriguian, Oliver He https://cjasn.asnjournals.org/content/6/3/679 10069440 henoch-schonlein purpura nephritis AE A urinary system AE that is characterized by when hemoglobin is released from RBCs into the bloodstream in excess of the binding capacity of haptoglobin. It occurs with chronic introvascular hemolysis and is called "brown urine." David Ameriguian, Oliver He hemosiderinuria https://en.wikipedia.org/wiki/Hemosiderinuria 10069395 haemosiderinuria AE A kidney AE that is characterized by rapid deterioration in kidney function in individuals with cirrhosis or fulminant liver failure. It is a life-threatening medical condition. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Hepatorenal_syndrome 10019846 hepatorenal syndrome AE A urinary system AE that is characterized by an excessive urinary excretion of oxalate. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Hyperoxaluria 10020703 hyperoxaluria AE A nephropathy AE that is characterized by a disease of the kidneys where the vasculature of the kidneys is damaged with an increase in blood pressure (high blood pressure). David Ameriguian, Oliver He https://www.myvmc.com/diseases/hypertensive-nephropathy/ 10055171 hypertensive nephropathy AE A urinary system AE that is characterized by low urinary-citrate excretion (defined as less than 320 mg/day), which can cause kidney stones in up to 2/3 of cases. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Kidney_stone_disease#Hypocitraturia 10070871 hypocitraturia AE A congenital AE that is characterized by a congenital disorder of the urethra where the urinary opening is not at the usual location on the head of the penis. David Ameriguian, Oliver He https://en.wikipedia.org/wiki/Hypospadias 10021093 hypospadias AE A bladder AE that is characterized by the hypotonic bladder muscle failing to squeeze hard enough to completely empty the bladder. David Ameriguian, Oliver He http://urologygroup.com/conditions-we-treat/urinary-retention/ 10058914 hypotonic urinary bladder AE An AE with the fragmentation of the nucleus Anthony Huffman, Oliver He https://en.wikipedia.org/wiki/Karyorrhexis https://jvi.asm.org/content/78/22/12672.long https://www.nature.com/articles/43591 10063393 karyorrhexis AE A cardiac disorder AE that shows a disorder of the heart's electrical activity, which can cause sudden, uncontrollable, dangerous arrhythmias in response to exercise or stress. The term "long QT" refers to an abnormal pattern seen on an EKG (electrocardiogram), a test that detects and records the heart's electrical activity. Madison Kalter, Jamie Ngai, Beccca Racz, Oliver He LQTS AE https://en.wikipedia.org/wiki/Long_QT_syndrome https://www.nhlbi.nih.gov/health-topics/long-qt-syndrome long QT syndrome AE an injection-site AE that displays erythema at the injection site. Liwei Wang, Oliver He injection site erythema AE an adverse event that occurs immediately after an injection Liwei Wang, Oliver He immediate post-injection reaction AE an adverse event that displays swelling at the injection site Liwei Wang, Oliver He Injection site swelling AE Jessica DeGuise, Oliver He 1003880 axillary vein thrombosis AE Jessica DeGuise, Oliver He 10063093 basilar artery thrombosis AE Jessica DeGuise, Oliver He 10062573 brain stem thrombosis AE Jessica DeGuise, Oliver He 10053994 cardiac ventricular thrombosis AE Jessica DeGuise, Oliver He 10079523 catheter site thrombosis AE Jessica DeGuise, Oliver He 10007830 cavernous sinus thrombosis AE Jessica DeGuise, Oliver He 10063176 prosthetic cardiac valve thrombosis AE An adverse event with the outcome of the cerebral venous sinus thrombosis (CVST), which occurs when a blood clot forms in the brain’s venous sinuses. CVST prevents blood from draining out of the brain. As a result, blood cells may break and leak blood into the brain tissues, forming a hemorrhage. Jessica DeGuise, Oliver He https://www.hopkinsmedicine.org/health/conditions-and-diseases/cerebral-venous-sinus-thrombosis 10083037 CVST cerebral venous sinus thrombosis AE Jessica DeGuise, Oliver He 10072240 foetal placental thrombosis AE Jessica DeGuise, Oliver He 10019636 hepatic artery thrombosis AE Jessica DeGuise, Oliver He 10019713 hepatic vein thrombosis AE Jessica DeGuise, Oliver He 10027397 mesenteric artery thrombosis AE Jessica DeGuise, Oliver He 10072564 peripheral artery thrombosis AE An adverse event in any patient presenting with both acute venous or arterial thrombosis AND new onset thrombocytopenia after a medical intervention such as vaccination. Oliver He, Jessica DeGuise TTS https://brightoncollaboration.us/wp-content/uploads/2021/04/TTS-Case-Finding-and-Definition-Process.v9.0-April-16-202115853.pdf thrombosis with thrombocytopenia syndrome AE Jessica DeGuise, Oliver He 10077022 postpartum thrombosis AE Jessica DeGuise, Oliver He 10036300 postpartum venous thrombosis AE Jessica DeGuise, Oliver He 10037459 pulmonary venous thrombosis AE Jessica DeGuise, Oliver He 10038380 renal artery thrombosis AE Jessica DeGuise, Oliver He 10062108 retinal vascular thrombosis AE Jessica DeGuise, Oliver He 10071316 spinal artery thrombosis AE Jessica DeGuise, Oliver He 10074600 splenic artery thrombosis AE Jessica DeGuise, Oliver He 10041659 splenic vein thrombosis AE Jessica DeGuise, Oliver He 10043634 thrombosis prophylaxis AE Jessica DeGuise, Oliver He 10063934 vascular stent thrombosis AE Jessica DeGuise, Oliver He 10078675 vascular access site thrombosis AE Jessica DeGuise, Oliver He 10069922 vascular graft thrombosis AE Jessica DeGuise, Oliver He 10063363 brachiocephalic vein thrombosis AE Jessica DeGuise, Oliver He 10057777 vertebral artery thrombosis AE Jessica DeGuise, Oliver He 10077623 portosplenomesenteric venous thrombosis AE Jessica DeGuise, Oliver He 10058568 arteriovenous fistula thrombosis AE Jessica DeGuise, Oliver He 10074494 hepatic vascular thrombosis AE Jessica DeGuise, Oliver He 10069550 intrapericardial thrombosis AE Jessica DeGuise, Oliver He 10081144 ophthalmic artery thrombosis AE Jessica DeGuise, Oliver He 10074349 ophthalmic vein thrombosis AE an arterial embolism AE that results in the blockage of the main artery of a lung or one of its branches by a substance that has travelled from elsewhere in the body through the bloodstream [SS] moved by relation 'SubclassOf' from lung disorder AE to arterial embolism on 01/07/14 SZ, SS, YH, JD WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299609 10037437 pulmonary thrombosis AE HPO: HP_0002204 SIDER: C0034065 Jessica DeGuise, Oliver He 10038518 renal vein thrombosis AE Jessica DeGuise, Oliver He 10038831 retinal artery thrombosis AE Jessica DeGuise, Oliver He 10074601 splenic thrombosis AE Jessica DeGuise, Oliver He 10042334 subclavian artery thrombosis AE Jessica DeGuise, Oliver He 10043626 thrombosis mesenteric vessel AE Jessica DeGuise, Oliver He 10044457 transverse sinus thrombosis AE Jessica DeGuise, Oliver He 10076190 vaccination site thrombosis AE Jessica DeGuise, Oliver He ophthalmic thrombosis AE Jessica DeGuise, Oliver He hepatic thrombosis AE Jessica DeGuise, Oliver He renal thrombosis AE Jessica DeGuise, Oliver He 10062108 retinal thrombosis AE Jessica DeGuise, Oliver He brain thrombosis AE cardiac thrombosis AE Jessica DeGuise, Oliver He 10019713 visceral venous thrombosis AE A definit case of TTS Oliver He, Jessica DeGuise Level 1 thrombosis with thrombocytopenia syndrome AE https://brightoncollaboration.us/wp-content/uploads/2021/04/TTS-Case-Finding-and-Definition-Process.v9.0-April-16-202115853.pdf Level 1 TTS AE A probable case of TTS Oliver He, Jessica DeGuise Level 2 thrombosis with thrombocytopenia syndrome AE https://brightoncollaboration.us/wp-content/uploads/2021/04/TTS-Case-Finding-and-Definition-Process.v9.0-April-16-202115853.pdf Level 2 TTS AE A possible case TTS Oliver He, Jessica DeGuise Level 3 thrombosis with thrombocytopenia syndrome AE https://brightoncollaboration.us/wp-content/uploads/2021/04/TTS-Case-Finding-and-Definition-Process.v9.0-April-16-202115853.pdf Level 3 TTS AE A reported case as TTS but there is insufficient evidence to meet any level of the case. Oliver He, Jessica DeGuise Level 4 thrombosis with thrombocytopenia syndrome AE https://brightoncollaboration.us/wp-content/uploads/2021/04/TTS-Case-Finding-and-Definition-Process.v9.0-April-16-202115853.pdf Level 4 TTS AE most likely not a case of TTS Oliver He, Jessica DeGuise Level 5 thrombosis with thrombocytopenia syndrome AE https://brightoncollaboration.us/wp-content/uploads/2021/04/TTS-Case-Finding-and-Definition-Process.v9.0-April-16-202115853.pdf Level 5 TTS AE an arterial embolism AE that results in the blockage of the main artery of a lung or one of its branches by a substance that has travelled from elsewhere in the body through the bloodstream [SS] moved by relation 'SubclassOf' from lung disorder AE to arterial embolism on 01/07/14 SZ, SS, YH, JD WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299609 10037340 pulmonary artery thrombosis AE HPO: HP_0002204 SIDER: C0034065 a thrombosis AE that occurs in subclavian vein. Among patients with effort-induced thrombosis with subclavian vein stenosis, the thrombosis occurs in the dominant arm in 80% of cases. SS WEB: http://emedicine.medscape.com/article/424777-overview#showall 10049446 subclavian thrombosis AE Jessica DeGuise, Oliver He 10027397 mesenteric thrombosis AE This is an AE which is the most common manifestation of abdominal tuberculosis. QY, JX, HY http://en.volupedia.org/wiki/Abdominal_tuberculosis 腹部淋巴结病 10073485 abdominal lymphadenopathy AE This is an AE which is any localized enlargement or swelling in the human abdomen. QY, JX, HY http://en.volupedia.org/wiki/Abdominal_mass 腹部肿块 10000077 abdominal mass AE This is an AE which is a disorder primarily of children which presents with episodes of abdominal pain without an accompanying headache. QY, JX, HY http://en.volupedia.org/wiki/Abdominal_migraine 腹型偏头痛 10049714 abdominal migraine AE This is an AE which is a type of abnormal and excessive growth of abdominal tissue. QY, JX, HY http://en.volupedia.org/wiki/Neoplasm 腹部肿瘤 10060925 abdominal neoplasm AE This is an AE which is a clinical sign in which there is pain upon removal of pressure rather than application of pressure to the abdomen. QY, JX, HY http://en.volupedia.org/wiki/Blumberg_sign 腹部反弹压痛 10052489 abdominal rebound tenderness AE This is an AE which is the tensing of the abdominal wall muscles to guard inflamed organs within the abdomen from the pain of pressure upon them. QY, JX, HY http://en.volupedia.org/wiki/Abdominal_guarding 腹部僵硬 10000090 abdominal rigidity AE This is an AE which is the observed or detectable abdominal signs, and experienced symptoms of an illness, injury, or condition . QY, JX, HY http://en.volupedia.org/wiki/Signs_and_symptoms 腹部疾病 10060926 abdominal symptom AE This is an AE which is pain or discomfort when an affected abdominal area is touched. QY, JX, HY http://en.volupedia.org/wiki/Tenderness_(medicine) 腹部压痛 10000097 abdominal tenderness AE This is an AE which is a closed sac, having a distinct envelope and division compared with the abdominal wall. QY, JX, HY http://en.volupedia.org/wiki/Cyst 腹壁囊肿 10051634 abdominal wall cyst AE This is an AE which a functional abnormality or disturbance occurs on the abdominal. QY, JX, HY http://en.volupedia.org/wiki/Disorder 腹壁疾病 10059625 abdominal wall disorder AE This is an AE which is a abdominal wall bleeding outside of blood vessels, due to either disease or trauma including injury or surgery and may involve blood continuing to seep from broken abdominal wall capillaries. QY, JX, HY http://en.volupedia.org/wiki/Hematoma 腹壁血肿 10067383 abdominal wall hematoma AE This is an AE which was unencapsulated and had no distinct borders and was infiltrative and composed of bundles and sheets of densely packed fusiform cells on the abdominal wall. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/24442574/ 腹壁肿块 10063005 abdominal wall mass AE This is an AE which is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of abdominal wall . QY, JX, HY http://en.volupedia.org/wiki/Cancer 恶性腹壁肿瘤 10071023 abdominal wall neoplasm malignant AE This is an AE which is the build-up of fluid in the abdominal wall. QY, JX, HY http://en.volupedia.org/wiki/Edema 腹壁水肿 10082609 abdominal wall edema AE This is an AE which is a surgical complication in which a abdominal wound ruptures along a surgical incision. QY, JX, HY http://en.volupedia.org/wiki/Wound_dehiscence 腹部伤口裂开 10066337 abdominal wound dehiscence AE This is an AE which is a intra-abdominal bleeding outside of blood vessels, due to either disease or trauma including injury or surgery and may involve blood continuing to seep from broken capillaries. QY, JX, HY http://en.volupedia.org/wiki/Hematoma 腹腔血肿 10056457 intra-abdominal hematoma AE This is an AE which refers to a sudden, severe abdominal pain and it is in many cases a medical emergency, requiring urgent and specific diagnosis. QY, JX, HY http://en.volupedia.org/wiki/Acute_abdomen 急腹症 10000647 acute abdomen AE This is an AE which is the condition of having at least three loose, liquid, or watery bowel movements each day and causes by bacterial. QY, JX, HY http://en.volupedia.org/wiki/Diarrhea 细菌性腹泻 10004016 bacterial diarrhea AE This is an AE which is a rare condition characterized by abdominal pain attributed to compression of the celiac artery and the celiac ganglia by the median arcuate ligament. QY, JX, HY http://en.volupedia.org/wiki/Median_arcuate_ligament_syndrome 腹腔动脉压迫综合征 10009838 coeliac artery compression syndrome AE This is an AE which is an abnormal narrowing in a blood vessel or other tubular organ or structure such as foramina and canals occured on coeliac artery . QY, JX, HY http://en.volupedia.org/wiki/Stenosis 腹腔动脉狭窄 10067325 coeliac artery stenosis AE This is an AE which is a protrusion of abdominal-cavity contents through the inguinal canal and it is congenital. QY, JX, HY http://en.volupedia.org/wiki/Inguinal_hernia 先天性腹股沟疝 10068321 congenital inguinal hernia AE This is an AE which is the condition of having at least three loose, liquid, or watery bowel movements each day and occurs on the neonatal. QY, JX, HY http://en.volupedia.org/wiki/Diarrhea 新生儿腹泻 10012743 diarrhea neonatal AE This is an AE which is defined as a gap of about 2.7 cm or greater between the two sides of the rectus abdominis muscle. QY, JX, HY http://en.volupedia.org/wiki/Diastasis_recti 腹直肌分离 10073169 diastasis recti abdominis AE This is an AE which is inflammation of the focal peritoneum, the lining of the inner wall of the abdomen and cover of the abdominal organs. QY, JX, HY http://en.volupedia.org/wiki/Peritonitis 局灶性腹膜炎 10084697 focal peritonitis AE This is an AE which is a birth defect in which the baby's intestines extend outside of the abdomen through a hole next to the belly button. QY, JX, HY http://en.volupedia.org/wiki/Gastroschisis 腹裂 10018046 gastroschisis AE This is an AE which is the condition of having at least three loose, liquid, or watery bowel movements each day and causes by the viral. QY, JX, HY http://en.volupedia.org/wiki/Diarrhea 病毒性腹泻 10051511 viral diarrhea AE This is an AE which is the formation of a blood clot inside a truncus coeliacus blood vessel, obstructing the flow of blood through the circulatory system. QY, JX, HY http://en.volupedia.org/wiki/Thrombosis 腹腔干血栓形成 10062363 truncus coeliacus thrombosis AE This is an AE which is the part of the body between the thorax (chest) and pelvis, in humans and in other vertebrates. QY, JX, HY http://en.volupedia.org/wiki/Abdomen#Human_abdomen 舟状腹 10078474 scaphoid abdomen AE This is an AE which is a collection of pus that has built up within the tissue of the retroperitoneal body. QY, JX, HY http://en.volupedia.org/wiki/Abscess 腹膜后脓肿 10038975 retroperitoneal abscess AE This is an AE which refers to accumulation of fluid in an retroperitoneal space, usually without loculation. QY, JX, HY http://en.volupedia.org/wiki/Effusion 腹膜后积液 10063637 retroperitoneal effusion AE This is an AE which is a disease featuring the proliferation of fibrous tissue in the retroperitoneum, the compartment of the body containing the kidneys, aorta, renal tract, and various other structures. QY, JX, HY http://en.volupedia.org/wiki/Retroperitoneal_fibrosis 腹膜后纤维化 10038979 retroperitoneal fibrosis AE This is an AE which is an accumulation of blood in the retroperitoneal space. QY, JX, HY http://en.volupedia.org/wiki/Retroperitoneal_bleeding 腹膜后血肿 10058360 retroperitoneal hematoma AE This is an AE which is a disease of the lymph nodes, in which retroperitoneal are abnormal in size or consistency. QY, JX, HY http://en.volupedia.org/wiki/Lymphadenopathy 腹膜后淋巴结肿大 10067015 retroperitoneal lymphadenopathy AE This is an AE which is a mass in the posterior of the peritoneum. QY, JX, HY http://en.volupedia.org/wiki/Abdominal_mass 腹膜后肿块 10071732 retroperitoneal mass AE This is an AE which refers fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the retroperitoneal. QY, JX, HY http://en.volupedia.org/wiki/Edema 腹膜后水肿 10038983 retroperitoneal edema AE This is an AE which is a collection of pus that has built up within the tissue of the peritoneal. QY, JX, HY http://en.volupedia.org/wiki/Abscess 腹腔脓肿 10034649 peritoneal abscess AE This is an AE which is fibrous bands that form between peritoneal tissues and organs, often as a result of injury during surgery. QY, JX, HY http://en.volupedia.org/wiki/Adhesion_(medicine) 腹膜粘连 10034650 peritoneal adhesions AE This is an AE which is a type of dialysis which uses the peritoneum in a person's abdomen as the membrane through which fluid and dissolved substances are exchanged with the blood. QY, JX, HY http://en.volupedia.org/wiki/Peritoneal_dialysis 腹膜透析 10034660 peritoneal dialysis AE This is an AE which is a rare serious complication typically caused by peritoneal dialysis. QY, JX, HY http://en.volupedia.org/wiki/Encapsulating_peritoneal_sclerosis 腹膜透析并发症 10067594 peritoneal dialysis complication AE This is an AE which is a functional abnormality or disturbance on the peritoneal. QY, JX, HY http://en.volupedia.org/wiki/Disorder 腹膜疾病 10061343 peritoneal disorder AE This is an AE which is blood escaping from the circulatory system from damaged peritoneal blood vessels. QY, JX, HY http://en.volupedia.org/wiki/Bleeding 腹膜出血 10034666 peritoneal hemorrhage AE This is an AE which is a surgical diagnostic procedure to determine if there is free floating fluid (most often blood) in the abdominal cavity. QY, JX, HY http://en.volupedia.org/wiki/Diagnostic_peritoneal_lavage 腹膜灌洗 10057837 peritoneal lavage AE This is an AE which is a hyperplasia of peritoneal mesothelial cells in serous membranes . QY, JX, HY http://en.volupedia.org/wiki/Mesothelial_hyperplasia 腹膜间皮增生 10072853 peritoneal mesothelial hyperplasia AE This is an AE which is inflammation of the peritoneum caused by virus. QY, JX, HY http://en.volupedia.org/wiki/Peritonitis 细菌性腹膜炎 10062070 peritonitis bacterial AE This is an AE which is a relatively uncommon manifestation of Streptococcus pneumoniae infection , but nonetheless, a potentially life-threatening one that requires prompt medical attention and treatment with antibiotics and, in some cases, surgery. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21358876/ 腹膜炎肺炎球菌 10034681 peritonitis pneumococcal AE This is an AE which is a protrusion of abdominal-cavity contents through the inguinal canal. QY, JX, HY http://en.volupedia.org/wiki/Inguinal_hernia 腹股沟疝 10022016 inguinal hernia AE This is an AE which is a protrusion of abdominal-cavity contents through the inguinal canal caused obstructive. QY, JX, HY http://en.volupedia.org/wiki/Inguinal_hernia 阻塞性腹股沟疝 10022021 inguinal hernia, obstructive AE This is an AE which is the abnormal exit of inguinal tissue or an organ, such as the bowel, through the wall of the cavity in which it normally resides. QY, JX, HY http://en.volupedia.org/wiki/Hernia 腹股沟肿块 10053217 inguinal mass AE This is an AE which is the name given to a common and aberrant immune response to infection with virus. QY, JX, HY http://en.volupedia.org/wiki/Feline_infectious_peritonitis 传染性腹膜炎 10071647 infectious peritonitis AE This is an AE which is a protrusion of abdominal-cavity contents through the inguinal canal and incarcerated. QY, JX, HY http://en.volupedia.org/wiki/Inguinal_hernia 嵌顿性腹股沟疝 10021613 incarcerated inguinal hernia AE This is an AE which is pneumatosis (abnormal presence of air or other gas) in the peritoneal cavity, a potential space within the abdominal cavity. QY, JX, HY http://en.volupedia.org/wiki/Pneumoperitoneum 气腹 10048299 pneumoperitoneum AE This is an AE which is a collection of pus that has built up within the tissue of the groin. QY, JX, HY http://en.volupedia.org/wiki/Abscess 腹股沟脓肿 10050269 groin abscess AE This is an AE which is the invasion of an organism's groin tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce. QY, JX, HY http://en.volupedia.org/wiki/Infection 腹股沟感染 10050821 groin infection AE This is an AE which occurs when there is protrusion of an internal organ into a retroperitoneal fossa or a foramen (congenital or acquired) in the abdominal cavity. QY, JX, HY http://en.volupedia.org/wiki/Internal_hernia 内部疝 10051989 internal hernia AE This is an AE which innervates the serratus anterior muscle and function gets injuried. QY, JX, HY http://en.volupedia.org/wiki/Long_thoracic_nerve 胸神经根损伤 10029187 nerve root injury thoracic AE This is an AE which occurs in most hospitalized Covid-19 patients. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/33016619/ 神经系统感染 10051295 neurological infection AE This is an AE which is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. QY, JX, HY http://en.volupedia.org/wiki/Neurological_disorder 神经症状 10060860 neurological symptom AE This is an AE which is a class of functional mental disorders of childhood involving chronic distress, but neither delusions nor hallucinations. QY, JX, HY http://en.volupedia.org/wiki/Neurosis 儿童神经性障碍 10029343 neurotic disorder of childhood AE This is an AE which is a term describing neuropathies with both sensory and motor involvement in a length dependant distribution where neurophysiology reveals axonal damage. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/26961897/ 多发性神经病变 10036111 polyneuropathy idiopathic progressive AE This is an AE which is a rare, fluid-filled neuroglial cavity within the spinal cord (syringomyelia), in the brain stem (syringobulbia), or in the nerves of the elbow, usually in a young age. QY, JX, HY http://en.volupedia.org/wiki/Syrinx_(medicine) 先天性中枢神经系统异常 10010411 congenital central nervous system anomaly AE This is an AE which refers to types of paralysis and occurs on cranial nerve caused by multiple reasons. QY, JX, HY http://en.volupedia.org/wiki/Palsy 颅神经多发性麻痹 10011314 cranial nerve palsies multiple AE This is an AE which is any loss of nerve supply regardless of the cause. QY, JX, HY http://en.volupedia.org/wiki/Denervation 去神经萎缩 10049643 denervation atrophy AE This is an AE which is a condition typified by a weakness of voluntary movement, or by partial loss of voluntary movement or by impaired movement and its occurs on IVth nerve. QY, JX, HY http://en.volupedia.org/wiki/Paresis ivth神经麻痹性痴呆 10054201 ivth nerve paresis AE This is an AE which refers to long thoracic nerve of paralysis, often accompanied by weakness and the loss of feeling and uncontrolled body movements such as shaking. QY, JX, HY http://en.volupedia.org/wiki/Palsy 胸长神经麻痹 10067925 long thoracic nerve palsy AE This is an AE which is paralysis caused by illness or injury that results in the partial or total loss of use of all four limbs and torso; paraplegia is similar but does not affect the arms. QY, JX, HY http://en.volupedia.org/wiki/Tetraplegia 颈脊髓麻痹 10057276 cervical spinal cord paralysis AE This is an AE which is a localized bleeding outside of blood vessels, due to either disease or trauma including injury or surgery and may involve blood continuing to seep from broken capillaries and it is spontaneous. QY, JX, HY http://en.volupedia.org/wiki/Hematoma 自发性血肿 10065304 spontaneous hematoma AE This is an AE which is a symptom related to a spectrum of disorders characterized by unintentional and purposeless motions and restlessness, often but not always accompanied by emotional distress. QY, JX, HY http://en.volupedia.org/wiki/Psychomotor_agitation 精神运动过度活跃 10037211 psychomotor hyperactivity AE This is an AE which is any deliberate interruption of signals traveling along a nerve, often for the purpose of pain relief. QY, JX, HY http://en.volupedia.org/wiki/Nerve_block 神经阻滞 10029173 nerve block AE This is an AE which is deterioration in the medical sense and it is the change from a higher to a lower form nerve. QY, JX, HY http://en.volupedia.org/wiki/Degeneration_(medical) 神经变性 10056677 nerve degeneration AE This is an AE which is injury to nervous tissue. QY, JX, HY http://en.volupedia.org/wiki/Nerve_injury 神经损伤 10052897 nerve injury AE This is an AE which will produce functional disability. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28453446/ 神经根损伤 10061310 nerve root injury AE This is an AE which is a disease of the cervical spine and a space-occupying lesion that occurs because of pathological problems with cervical nerve roots. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28453446/ 颈神经根损伤 10029183 nerve root injury cervical AE This is an AE which refers to a small class of medical conditions affecting the nervous system. QY, JX, HY http://en.volupedia.org/wiki/Nervous_system_disease 神经系统紊乱 10029202 nervous system disorder AE This is an AE which is injury to nervous tissue. QY, JX, HY http://en.volupedia.org/wiki/Nerve_injury 神经系统损伤 10080898 nervous system injury AE This is an AE which are a group of birth defects in which an opening in the spine or cranium remains from early in human development. QY, JX, HY http://en.volupedia.org/wiki/Neural_tube_defect 神经管缺陷 10052046 neural tube defect AE This is an AE which is a syndrome of unknown cause; although many specific risk factors have been identified (such as; post-operatively, post-infectious, post-traumatic or post-vaccination), the cause is still unknown. QY, JX, HY http://en.volupedia.org/wiki/Parsonage%E2%80%93Turner_syndrome 神经性肌萎缩 10029229 neuralgic amyotrophy AE This is an AE which is a usually benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves. QY, JX, HY http://en.volupedia.org/wiki/Schwannoma 神经膜瘤 10029234 neurilemmoma AE This is an AE which is a usually benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves. QY, JX, HY http://en.volupedia.org/wiki/Schwannoma 良性神经膜瘤 10029235 neurilemmoma benign AE This is an AE which is inflammation of a cranial nerveor the general inflammation of the peripheral nervous system. QY, JX, HY http://en.volupedia.org/wiki/Neuritis 神经炎颅 10029244 neuritis cranial AE This is an AE which is a type of cancer that forms in certain types of nerve tissue. QY, JX, HY http://en.volupedia.org/wiki/Neuroblastoma 神经母细胞瘤 10029260 neuroblastoma AE This is an AE which is the progressive loss of structure or function of neurons, which may ultimately involve cell death. QY, JX, HY http://en.volupedia.org/wiki/Neurodegeneration 神经退行性疾病 10053643 neurodegenerative disorder AE This is an AE which is a skin disorder characterized by chronic itching and scratching. QY, JX, HY http://en.volupedia.org/wiki/Lichen_simplex_chronicus 神经性皮炎 10029263 neurodermatitis AE This is an AE which is a group of disorders that affect the development of the nervous system, leading to abnormal brain function which may affect emotion, learning ability, self-control, and memory. QY, JX, HY http://en.volupedia.org/wiki/Neurodevelopmental_disorder 神经发育障碍 10064062 neuro developmental disorder AE This is an AE which are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. QY, JX, HY http://en.volupedia.org/wiki/Neuroendocrine_tumor 神经内分泌肿瘤 10052399 neuroendocrine tumor AE This is an AE which is a benign nerve-sheath tumor in the peripheral nervous system. QY, JX, HY http://en.volupedia.org/wiki/Neurofibroma 神经纤维瘤 10029267 neurofibroma AE This is an AE which is a group of three conditions in which tumors grow in the nervous system. QY, JX, HY http://en.volupedia.org/wiki/Neurofibromatosis 神经纤维瘤病 10029268 neurofibromatosis AE This is an AE which is the inability to control defecation due to a deterioration of or injury to the nervous system, resulting in faecal incontinence or constipation. QY, JX, HY http://en.volupedia.org/wiki/Neurogenic_bowel_dysfunction 神经源性肠 10048657 neurogenic bowel AE This is an AE which is a distributive type of shock resulting in hypotension (low blood pressure), often with bradycardia (slowed heart rate), caused by disruption of autonomic nervous system pathways. QY, JX, HY http://en.volupedia.org/wiki/Neurogenic_shock 神经源性休克 10058119 neurogenic shock AE This is an AE which is a neuropsychological condition in which, after damage to one hemisphere of the brain is sustained, a deficit in attention to and awareness of one side of the field of vision is observed. QY, JX, HY http://en.volupedia.org/wiki/Hemispatial_neglect 神经系统忽视综合症 10029289 neurologic neglect syndrome AE This is an AE which is any mental neurologic disorder that manifests as physical symptoms that suggest illness or injury, but cannot be explained fully by a general medical condition or by the direct effect of a substance, and are not attributable to another mental disorder. QY, JX, HY http://en.volupedia.org/wiki/Somatic_symptom_disorder 神经躯体症状障碍 10078080 neurologic somatic symptom disorder AE This is an AE which is a drooping or falling of the upper eyelid caused by neurological disorder. QY, JX, HY http://en.volupedia.org/wiki/Ptosis_(eyelid) 眼睑神经障碍 10061312 neurological eyelid disorder AE This is an AE which block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. QY, JX, HY http://en.volupedia.org/wiki/Neuromuscular-blocking_drug 神经肌肉阻滞 10029315 neuromuscular blockade AE This is an AE which ailments that impair the functioning of the muscles, either directly, being pathologies of the voluntary muscle, or indirectly, being pathologies of nerves or neuromuscular junctions and it will cause pain. QY, JX, HY http://en.volupedia.org/wiki/Neuromuscular_disease 神经肌肉疼痛 10074313 neuromuscular pain AE This is an AE which is the degree to which a chemical substance or a particular mixture of substances can damage neuromuscular. QY, JX, HY http://en.volupedia.org/wiki/Toxicity 神经肌肉毒性 10062284 neuromuscular toxicity AE This is an AE which is a form of peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. QY, JX, HY http://en.volupedia.org/wiki/Neuromyotonia 神经性肌强直 10072359 neuromyotonia AE This is an AE which refers to progressive degeneration of a weight-bearing joint and musclar , a process marked by bony destruction, bone resorption, and eventual deformity due to loss of sensation. QY, JX, HY http://en.volupedia.org/wiki/Neuropathic_arthropathy 神经性肌肉萎缩 10075469 neuropathic muscular atrophy AE This is an AE which is a general term describing disease affecting the peripheral nerves, meaning nerves beyond the brain and spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Peripheral_neuropathy 周围神经病变 10029331 neuropathy peripheral AE This is an AE which refers to the neurological and psychiatric manifestations of systemic lupus erythematosus. QY, JX, HY http://en.volupedia.org/wiki/Neuropsychiatric_systemic_lupus_erythematosus 神经精神狼疮 10063663 neuropsychiatric lupus AE This is an AE which are the observed or detectable signs, and experienced symptoms of an illness, injury, or condition. QY, JX, HY http://en.volupedia.org/wiki/Signs_and_symptoms#Neuropsychiatric 神经精神症状 10078497 neuropsychiatric symptoms AE This is an AE which refers to a type of sarcoidosis, a condition of unknown cause featuring granulomas in various tissues, in this type involving the central nervous system (brain and spinal cord). QY, JX, HY http://en.volupedia.org/wiki/Neurosarcoidosis 神经类肉瘤病 10078011 neurosarcoidosis AE This is an AE which is a partial or total inability to hear caused by neurosensory. QY, JX, HY http://en.volupedia.org/wiki/Hearing_loss 感觉神经的听觉迟钝 10067587 neurosensory hypoacusis AE This is an AE which is a class of functional mental disorders involving chronic distress, but neither delusions nor hallucinations. QY, JX, HY http://en.volupedia.org/wiki/Neurosis 神经衰弱症 10029333 neurosis AE This is an AE which refers to infection of the central nervous system in a patient with syphilis. QY, JX, HY http://en.volupedia.org/wiki/Neurosyphilis 神经性梅毒 10029339 neurosyphilis AE This is an AE which is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. QY, JX, HY http://en.volupedia.org/wiki/Neurotoxicity 神经毒性 10029350 neurotoxicity AE This is an AE which refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/29698813/ 向神经角膜病 10069732 neurotrophic keratopathy AE This is an AE which is a painful condition affecting the posterior head in the distributions of the greater occipital nerve (GON), lesser occipital nerve (LON), third occipital nerve (TON), or a combination of the three. QY, JX, HY http://en.volupedia.org/wiki/Occipital_neuralgia 枕神经痛 10068106 occipital neuralgia AE This is an AE which is the name of a dystonic reaction to certain drugs or medical conditions characterized by a prolonged involuntary upward deviation of the eyes. QY, JX, HY http://en.volupedia.org/wiki/Oculogyric_crisis 动眼神经危象 10030071 oculogyric crisis AE This is an AE which is a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell. QY, JX, HY http://en.volupedia.org/wiki/Oligodendroglioma 少突神经胶质瘤 10030286 oligodendroglioma AE This is an AE which is associated with typical vascular risk factors and with one systemic disease in particular: giant cell arteritis (GCA). QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/31584535/ 光学缺血性神经病变 10030924 optic ischemic neuropathy AE This is an AE which can be defined as remote effects of cancer that are not caused by the tumor and its metastasis, or by infection, ischemia or metabolic disruptions. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/17480225/ 多种神经综合症 10072106 paraneoplastic neurological syndrome AE This is an AE which resulting from a lesion involving the cisternal portion of the nerve prior to its anatomical bifurcation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/16682550/ 麻痹性痴呆脑神经 10061911 paresis cranial nerve AE This is an AE which is a syndrome that causes episodes of increased activity of the sympathetic nervous system. QY, JX, HY http://en.volupedia.org/wiki/Paroxysmal_sympathetic_hyperactivity 阵发性交感神经过度活跃 10078476 paroxysmal sympathetic hyperactivity AE This is an AE which is a progressively worsening condition where muscles in the extremities gradually weaken. QY, JX, HY http://en.volupedia.org/wiki/Multifocal_motor_neuropathy 多病灶的运动神经病变 10065579 multifocal motor neuropathy AE This is an AE which is a closed sac, having a distinct envelope and division compared with the nearby perineurial tissue. QY, JX, HY http://en.volupedia.org/wiki/Cyst 神经束膜囊肿 10051766 perineurial cyst AE This is an AE which is a medical condition caused by dissolved gases emerging from solution as bubbles inside the peripheral nerve tissues during decompression. QY, JX, HY http://en.volupedia.org/wiki/Decompression_sickness 周围神经减压 10057610 peripheral nerve decompression AE This is an AE which refers to damage to peripheral nerve beyond the capability to repair. QY, JX, HY http://en.volupedia.org/wiki/Destruction 周围神经损伤 10034584 peripheral nerve destruction AE This is an AE which resulting from trauma can be severe and permanently debilitating. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30187777/ 周围神经损伤 10034586 peripheral nerve injury AE This is an AE which is any damage or abnormal change in the tissue of an peripheral nerve , usually caused by disease or trauma. QY, JX, HY http://en.volupedia.org/wiki/Lesion 周围神经病变 10067633 peripheral nerve lesion AE This is an AE which is the purposeful modulation of the nervous system's activity using invasive or non-invasive means on the peripheral nerve. QY, JX, HY http://en.volupedia.org/wiki/Neurostimulation 周围神经神经刺激 10034587 peripheral nerve neurostimulation AE This is an AE which is a paralysis on common fibular nerve that affects patient’s ability to lift the foot at the ankle. QY, JX, HY http://en.volupedia.org/wiki/Peroneal_nerve_paralysis 外周神经麻痹 10058530 peripheral nerve palsy AE This is an AE which is a paralysis on common fibular nerve that affects patient’s ability to lift the foot at the ankle. QY, JX, HY http://en.volupedia.org/wiki/Peroneal_nerve_paralysis 外周神经麻痹性痴呆 10071663 peripheral nerve paresis AE This is an AE which is a nerve in the lower leg that provides sensation over the posteriolateral part of the leg and the knee joint. QY, JX, HY http://en.volupedia.org/wiki/Common_peroneal_nerve 腓神经损伤 10034700 peroneal nerve injury AE This is an AE which is a chronic disabling condition of the peripheral nerves, characterized by symmetrical distal numbness and paresthesia, often accompanied with pain and weakness. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/26700499/ 慢性多发性神经病 10064135 polyneuropathy chronic AE This is an AE which is damage or disease affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, and burning pain in malignant disease. QY, JX, HY http://en.volupedia.org/wiki/Polyneuropathy 恶性疾病中的多神经病变 10036115 polyneuropathy in malignant disease AE This is an AE which is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles). QY, JX, HY http://en.volupedia.org/wiki/Postherpetic_neuralgia 后疱疹的神经痛 10036376 post herpetic neuralgia AE This is an AE which is a nerve in the human body that supplies the posterior portion of the upper limb and its funtion get injury. QY, JX, HY http://en.volupedia.org/wiki/Radial_nerve 桡神经损伤 10037749 radial nerve injury AE This is an AE whichis a problem associated with the radial nerve resulting from injury consisting of acute trauma to the radial nerve. QY, JX, HY http://en.volupedia.org/wiki/Radial_nerve_dysfunction 桡神经麻痹 10037749 radial nerve palsy AE This is an AE which is pain "radiated" along the dermatome (sensory distribution) of a nerve due to inflammation or other irritation of the nerve root (radiculopathy) at its connection to the spinal column. QY, JX, HY http://en.volupedia.org/wiki/Radicular_pain 神经根痛 10059604 radicular pain AE This is an AE which refers to a set of conditions in which one or more nerves are affected and do not work properly (a neuropathy). QY, JX, HY http://en.volupedia.org/wiki/Radiculopathy 神经根综合征 10052442 radicular syndrome AE This is an AE which is pain "radiated" along the dermatome (sensory distribution) of a brachial nerve due to inflammation or other irritation of the nerve root (radiculopathy) at its connection to the spinal column. QY, JX, HY http://en.volupedia.org/wiki/Radicular_pain 臂神经根炎 10037778 radiculitis brachial AE This is an AE which is a relatively common neurological disorder resulting from nerve root dysfunction, which is often due to mechanical compression. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25985461/ 颈神经根炎 10050092 radiculitis cervical AE This is an AE which is one of the most common disorders evaluated by neurologists and is a leading referral diagnosis for the performance of electromyography. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/17445735/ 腰骶神经根炎 10050085 radiculitis lumbosacral AE This is an AE which refers to a set of conditions in which one or more nerves are affected and do not work properly (a neuropathy). QY, JX, HY http://en.volupedia.org/wiki/Radiculopathy 神经根病 10037779 radiculopathy AE This is an AE which a condition affecting the nerves of the peripheral sciatic nervous system. QY, JX, HY http://en.volupedia.org/wiki/Neuropathy_(disambiguation) 坐骨神经神经病 10048950 sciatic nerve neuropathy AE This is an AE which is a large nerve in humans and other vertebrate animals which is the largest branch of the sacral plexus and runs alongside the hip joint and down the lower limb and it maybe palsy. QY, JX, HY http://en.volupedia.org/wiki/Sciatic_nerve 坐骨神经麻痹 10039672 sciatic nerve palsy AE This is an AE which has been traditionally considered presenting with symptoms reflecting the length-dependent impairment of unmyelinated C and thinly myelinated A@ fibres, most commonly reported as burning feet. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28665811/ 小纤维神经病 10073928 small fibre neuropathy AE This is an AE which is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. QY, JX, HY http://en.volupedia.org/wiki/Guillain%E2%80%93Barr%C3%A9_syndrome#Clinical_subtypes 亚急性炎性脱髓鞘性多发性神经病 10081726 subacute inflammatory demyelinating polyneuropathy AE This is an AE which refers to damage to sympathetic nerve beyond the capability to repair. QY, JX, HY http://en.volupedia.org/wiki/Destruction 交感神经破坏 10042740 sympathetic nerve destruction AE This is an AE which is one of two divisions of the autonomic nervous system, along with the parasympathetic nervous system. QY, JX, HY http://en.volupedia.org/wiki/Sympathetic_nervous_system#Sympathicotonia 交感神经症 10051691 sympathicotonia AE This is an AE which includes those caused by industrial toxins (organic solvents and organophosphates), heavy metals (arsenic, thallium, and lead), drugs and alcohol. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21897232/ 中毒性神经病 10067722 toxic neuropathy AE This is an AE which is a condition typified by a weakness of voluntary movement, or by partial loss of voluntary movement or by impaired movement caused by trigeminal nerve. QY, JX, HY http://en.volupedia.org/wiki/Paresis 三叉神经麻痹 10068008 trigeminal nerve paresis AE This is an AE which refers to various types of paralysis, often accompanied by weakness and the loss of feeling and uncontrolled body movements such as shaking and occurs on trigeminal. QY, JX, HY http://en.volupedia.org/wiki/Palsy 三叉神经麻痹 10049788 trigeminal palsy AE This is an AE which takes three clinical forms: meningitis (TBM), intracranial tuberculoma, and spinal arachnoiditis. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28281443/ 中枢神经系统结核 10061391 tuberculosis of central nervous system AE This is an AE which result in both sensory and motor deficits within the hand. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25442770/ 尺神经损伤 10045378 ulnar nerve injury AE This is an AE which is a chronic clinical condition characterized by a delayed onset ulnar neuropathy after an injury to the elbow. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30939566/ 尺神经麻痹 10059790 ulnar nerve palsy AE This is an AE which is inflammation of a ulnar nerve or the general inflammation of the peripheral ulnar nervous system. QY, JX, HY http://en.volupedia.org/wiki/Neuritis 尺神经炎 10045380 ulnar neuritis AE This is an AE which Is an injury or abnormality that occurs in the neural pathway above the anterior horn cell of the spinal cord or motor nuclei of the cranial nerves. QY, JX, HY http://en.volupedia.org/wiki/Upper_motor_neuron_lesion 上运动神经元损伤 10046298 upper motor neurone lesion AE This is an AE which is the tenth cranial nerve or CN X, and interfaces with the parasympathetic control of the heart, lungs, and digestive tract and its function gets disorder. QY, JX, HY http://en.volupedia.org/wiki/Vagus_nerve 迷走神经紊乱 10061403 vagus nerve disorder AE This is an AE which is damage to the viiith nerve caused by an external force. QY, JX, HY http://en.volupedia.org/wiki/Injury 第八神经损伤 10047409 viiith nerve injury AE This is an AE which is any damage or abnormal change in the tissue of viiith nerve , usually caused by disease or trauma. QY, JX, HY http://en.volupedia.org/wiki/Lesion 第八神经病变 10062177 viiith nerve lesion AE This is an AE which is a loss of motor function in one or more muscles occured viith nerve . QY, JX, HY http://en.volupedia.org/wiki/Paralysis 颅神经麻痹 10050040 viith nerve paralysis AE This is an AE which refers to a functional abnormality or disturbance on VIIth nerve. QY, JX, HY http://en.volupedia.org/wiki/Disorder 颅神经紊乱 10053646 vith nerve disorder AE This is an AE which is a loss of motor function in one or more muscles occured vith nerve . QY, JX, HY http://en.volupedia.org/wiki/Paralysis 颅神经麻痹 10071044 vith nerve paresis AE This is an AE which is a nerve responsible for sensation in the face and motor functions which get injury. QY, JX, HY http://en.volupedia.org/wiki/Trigeminal_nerve 第五神经损伤 10047723 vth nerve injury AE This is an AE which is an injury to the spinal accessory nerve which results in diminished or absent function of the sternocleidomastoid muscle and upper portion of the trapezius muscle. QY, JX, HY http://en.volupedia.org/wiki/Accessory_nerve_disorder 副神经障碍 10060929 accessory nerve disorder AE This is an AE which is a benign tumor that develops on the vestibulocochlear nerve that passes from the inner ear to the brain. QY, JX, HY http://en.volupedia.org/wiki/Vestibular_schwannoma 听神经瘤 10000523 acoustic neuroma AE This is an AE which is a variant of Guillain–Barré syndrome. It is characterized by acute paralysis and loss of reflexes without sensory loss. QY, JX, HY http://en.volupedia.org/wiki/Acute_motor_axonal_neuropathy 急性运动轴突神经病 10076658 acute motor axonal neuropathy AE This is an AE which is a variant of Guillain–Barré syndrome. It is characterized by acute paralysis and loss of reflexes without sensory loss. QY, JX, HY http://en.volupedia.org/wiki/Acute_motor_axonal_neuropathy 急性运动感觉轴突神经病 10076657 acute motor-sensory axonal neuropathy AE This is an AE which is acute damage or disease affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, and burning pain. QY, JX, HY http://en.volupedia.org/wiki/Polyneuropathy 急性多神经病 10066699 acute polyneuropathy AE This is an AE which is an area of swelling (edema) of the lower layer of skin and tissue just under the skin or mucous membranes. QY, JX, HY http://en.volupedia.org/wiki/Angioedema 血管神经性水肿 10002473 angioneurotic edema AE This is an AE which is an eating disorder characterized by low weight, food restriction, body image disturbance, fear of gaining weight, and an overpowering desire to be thin. QY, JX, HY http://en.volupedia.org/wiki/Anorexia_nervosa 神经性厌食症 10002649 anorexia nervosa AE This is an AE which sometimes called autoimmune neuritis, may be a forme fruste of systemic lupus erythematosus (SLE) associated neuropathy. QY, JX, HY http://en.volupedia.org/wiki/Autoimmune_optic_neuropathy 自身免疫性神经病变 10070439 autoimmune neuropathy AE This is an AE which is a single autonomic seizure lasting between 2+ to 5+ minutes or two or more seizures within a five-minute period without the person returning to normal between them. QY, JX, HY http://en.volupedia.org/wiki/Status_epilepticus 自主神经发作 10049612 autonomic seizure AE This is an AE which is a nerve of the human body, that originates from the brachial plexus (upper trunk, posterior division, posterior cord) at the level of the axilla (armpit) and carries nerve fibers from C5 and C6 which it maybe get injury. QY, JX, HY http://en.volupedia.org/wiki/Axillary_nerve 腋神经损伤 10003879 axillary nerve injury AE This is an AE which is damage or disease affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the axonal and demyelinating body, featuring weakness, numbness, and burning pain. QY, JX, HY http://en.volupedia.org/wiki/Polyneuropathy 轴突和脱髓鞘性多发性神经病 10084153 axonal and demyelinating polyneuropathy AE This is an AE which is a rare, autosomal recessive[1] neurological disorder that causes disorganization of neurofilaments. QY, JX, HY http://en.volupedia.org/wiki/Giant_axonal_neuropathy 轴突神经病变 10003882 axonal neuropathy AE This is an AE which is a collection of pus that has built up within the tissue of the central nervous system caused by bacterial. QY, JX, HY http://en.volupedia.org/wiki/Abscess 中枢神经系统细菌性脓肿 10004015 bacterial abscess central nervous system AE This is an AE which is a group of physical problems that occur when the group of nuclei in the brain known as the basal ganglia fail to properly suppress unwanted movements or to properly prime upper motor neuron circuits to initiate motor function and a type of symptom is haematoma. QY, JX, HY http://en.volupedia.org/wiki/Basal_ganglia_disease 基底神经节血肿 10077031 basal ganglia hematoma AE This is an AE which is a group of physical problems that occur when the group of nuclei in the brain known as the basal ganglia fail to properly suppress unwanted movements or to properly prime upper motor neuron circuits to initiate motor function and a type of symptom is stroke. QY, JX, HY http://en.volupedia.org/wiki/Basal_ganglia_disease 基底神经节中风 10071043 basal ganglia stroke AE This is an AE which is a group of subcortical nuclei, of varied origin, in the brains of vertebrates and it is begin degeneration. QY, JX, HY http://en.volupedia.org/wiki/Basal_ganglia 基底神经节变性 10004153 basal ganglion degeneration AE This is an AE which is an outmoded term for a condition now designated as a form of conversion disorder. QY, JX, HY http://en.volupedia.org/wiki/Hysterical_Blindness 神经性失明 10005179 blindness hysterical AE This is an AE which is a cancerous glioma tumor in the brainstem. QY, JX, HY http://en.volupedia.org/wiki/Brainstem_glioma 脑干神经胶质瘤 10006143 brain stem glioma AE This is an AE which is an eating disorder characterized by binge eating followed by purging; and excessive concern with body shape and weight. QY, JX, HY http://en.volupedia.org/wiki/Bulimia_nervosa 神经性暴食症 10006550 bulimia nervosa AE This is an AE which is a psychiatric syndrome which presents a set of symptoms similar to those of heart disease. QY, JX, HY http://en.volupedia.org/wiki/Da_Costa%27s_syndrome 心脏神经综合症 10007592 cardiac neurosis AE This is an AE which is a collection of pus that has built up within the tissue of the central nervous system. QY, JX, HY http://en.volupedia.org/wiki/Abscess 中枢神经系统脓肿 10061044 central nervous system abscess AE This is an AE which is the part of the nervous system consisting primarily of the brain and spinal cord which is got injury. QY, JX, HY http://en.volupedia.org/wiki/Central_nervous_system 中枢神经系统损伤 10081266 central nervous system injury AE This is an AE which is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells and occurs on central nervous system. QY, JX, HY http://en.volupedia.org/wiki/Leukemia 中枢神经系统白血病 10066231 central nervous system leukaemia AE This is an AE which is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the central nervous system body. QY, JX, HY http://en.volupedia.org/wiki/Lupus 中枢神经系统狼疮 10076328 central nervous system lupus AE This is an AE which is the part of the nervous system consisting primarily of the brain and spinal cord and it has mass. QY, JX, HY http://en.volupedia.org/wiki/Central_nervous_system 中枢神经系统肿块 10054937 central nervous system mass AE This is an AE which is a tumor affecting the cental nervous system. QY, JX, HY http://en.volupedia.org/wiki/Nervous_system_neoplasm 中枢神经系统肿瘤 10007958 central nervous system neoplasm AE This is an AE which is group of disorders that destroy blood vessels by inflammation and occurs on central nervous system. QY, JX, HY http://en.volupedia.org/wiki/Vasculitis 中枢神经系统刺激 10061444 central nervous system stimulation AE This is an AE which refers to virus infections usually begin in the peripheral tissues, and can invade the mammalian system by spreading into the peripheral nervous system and more rarely the CNS. QY, JX, HY http://en.volupedia.org/wiki/Central_nervous_system_viral_disease 中枢神经系统血管炎 10081778 central nervous system vasculitis AE This is an AE which is caused by viruses that attack the CNS. QY, JX, HY http://en.volupedia.org/wiki/Central_nervous_system_viral_disease 中枢神经系统病毒感染 10061037 central nervous system viral infection AE This is an AE which is any disorder of the nervous system and occurs on congenital time. QY, JX, HY http://en.volupedia.org/wiki/Neurological_disorder 先天性神经障碍 10062345 congenital neurological disorder AE This is an AE which is an impaired functioning of one of the twelve cranial nerves. QY, JX, HY http://en.volupedia.org/wiki/Cranial_nerve_disease 颅神经疾病 10061093 cranial nerve disorder AE This is an AE which are the nerves that emerge directly from the brain (including the brainstem) and get injury. QY, JX, HY http://en.volupedia.org/wiki/Cranial_nerves 颅神经损伤 10061094 cranial nerve injury AE This is an AE which is a loss of motor function in one or more muscles and occurs on cranial nerve. QY, JX, HY http://en.volupedia.org/wiki/Paralysis 颅神经麻痹 10061908 cranial nerve paralysis AE This is an AE which is a paralysis of the arm caused by injury to the upper group of the arm's main nerves, specifically the severing of the upper trunk C5–C6 nerves. QY, JX, HY http://en.volupedia.org/wiki/Erb%27s_palsy ERB麻痹 10015113 erb's palsy AE This is an AE which is pain in the distribution of a nerve or nerves, as in intercostal neuralgia, trigeminal neuralgia, and glossopharyngeal neuralgia. QY, JX, HY http://en.volupedia.org/wiki/Neuralgia 面部神经痛 10061594 facial neuralgia AE This is an AE which is a nerve in the thigh that supplies skin on the upper thigh and inner leg, and the muscles that extend the knee injury. QY, JX, HY http://en.volupedia.org/wiki/Femoral_nerve 股神经损伤 10016451 femoral nerve injury AE This is an AE which refers to various types of paralysis,often accompanied by weakness and the loss of feeling and uncontrolled body movements such as shaking and occurs on femoral nerve. QY, JX, HY http://en.volupedia.org/wiki/Palsy 股神经麻痹 10049789 femoral nerve palsy AE This is an AE which is a variant of neuroblastoma that is surrounded by ganglion cells. QY, JX, HY http://en.volupedia.org/wiki/Ganglioneuroblastoma 节细胞神经母细胞瘤 10017708 ganglioneuroblastoma AE This is an AE which is a rare and benign tumor of the autonomic nerve fibers arising from neural crest sympathogonia, which are completely undifferentiated cells of the sympathetic nervous system. QY, JX, HY http://en.volupedia.org/wiki/Ganglioneuroma 神经节细胞瘤 10017709 ganglioneuroma AE This is an AE which is a type of tumor that starts in the glial cells of the brain or the spine. QY, JX, HY http://en.volupedia.org/wiki/Glioma 神经胶质瘤 10018338 glioma AE This is an AE which is a nonspecific reactive change of glial cells in response to damage to the central nervous system (CNS). QY, JX, HY http://en.volupedia.org/wiki/Gliosis 神经胶质增生症 10018341 gliosis AE This is an AE which is a loss of motor function in one or more muscles and occurs on glossopharyngeal nerve. QY, JX, HY http://en.volupedia.org/wiki/Paralysis 舌咽神经瘫痪 10051270 glossopharyngeal nerve paralysis AE This is an AE which is pain in the distribution of a nerve or nerves, as in intercostal neuralgia, trigeminal neuralgia, and glossopharyngeal neuralgia. QY, JX, HY http://en.volupedia.org/wiki/Neuralgia#Glossopharyngeal 舌咽神经神经痛 10018391 glossopharyngeal neuralgia AE This is an AE which is a viral disease characterized by a painful skin rash with blisters in a localized area infection neurological. QY, JX, HY http://en.volupedia.org/wiki/Shingles 神经带状疱疹感染 10061208 herpes zoster infection neurological AE This is an AE which is frequently involved in head and neck afflictions as a result of its long course. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/2698526/ 舌下神经麻痹 10069450 hypoglossal nerve paralysis AE This is an AE which refers to IIIrd nerve functional abnormality or disturbance. QY, JX, HY http://en.volupedia.org/wiki/Disorder iiird神经障碍 10053644 iiird nerve disorder AE This is an AE which is damage to the body caused by an external force and occurs on iiird nerve. QY, JX, HY http://en.volupedia.org/wiki/Injury iiird神经损伤 10021281 iiird nerve injury AE This is an AE which is a loss of motor function in one or more muscles and occurs on IIIrd nerve. QY, JX, HY http://en.volupedia.org/wiki/Paralysis iiird神经麻痹 10021283 iiird nerve paralysis AE This is an AE which is a condition typified by a weakness of voluntary movement, or by partial loss of voluntary movement or by impaired movement and occurs on IIIrd nerve. QY, JX, HY http://en.volupedia.org/wiki/Paresis iiird神经麻痹性痴呆 10054202 iiird nerve paresis AE This is an AE which is association with other neurological deficits. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/16705532/ ivth神经麻痹 10023110 ivth nerve paralysis AE This is an AE which is a lesion which affects nerve fibers traveling from the lower motor neuron(s) in the anterior horn/anterior grey column of the spinal cord, or in the motor nuclei of the cranial nerves, to the relevant muscle(s). QY, JX, HY http://en.volupedia.org/wiki/Lower_motor_neuron_lesion 下运动神经元损伤 10024962 lower motor neurone lesion AE This is an AE which is pain going down the leg from the lower back. QY, JX, HY http://en.volupedia.org/wiki/Sciatica 腰椎神经根病 10050219 lumbar radiculopathy AE This is an AE which is a disorder of the network of nerves in the lumbosacral plexus. QY, JX, HY http://en.volupedia.org/wiki/Plexopathy 腰荐神经丛病变 10075478 lumbosacral plexopathy AE This is an AE which refers injuries to the lumbosacral plexus are predominantly witnessed as bone injuries. QY, JX, HY http://en.volupedia.org/wiki/Lumbosacral_plexus 腰骶神经丛损伤 10025015 lumbosacral plexus injury AE This is an AE which depends on what portion of the plexus gets involved in the disease process. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25299286/ 腰骶神经丛病变 10025016 lumbosacral plexus lesion AE This is an AE which is pain going down the leg from the lower back. QY, JX, HY http://en.volupedia.org/wiki/Sciatica 腰骶神经根病 10076578 lumbosacral radiculopathy AE This is an AE which is a nerve in humans and other animals in the upper limb and is injuried of median nerve at different levels causes different syndromes with varying motor and sensory deficits. QY, JX, HY http://en.volupedia.org/wiki/Median_nerve#Injury 正中神经损伤 10027067 median nerve injury AE This is an AE which is a common type of primary brain cancer in children. QY, JX, HY http://en.volupedia.org/wiki/Medulloblastoma 成神经管细胞瘤 10027107 medulloblastoma AE This is an AE which is a neurologic symptoms of neuroborreliosis. QY, JX, HY http://en.volupedia.org/wiki/Neuroborreliosis 脑膜神经根炎 10050169 meningoradiculitis AE This is an AE which is a general term describing disease affecting the peripheral nerves, meaning nerves beyond the brain and spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Peripheral_neuropathy 单神经病多路复用 10027918 mononeuropathy multiplex AE This is an AE which is a benign neuroma of an intermetatarsal plantar nerve, most commonly of the second and third intermetatarsal spaces (between the second/third and third/fourth metatarsal heads; the first is of the big toe), which results in the entrapment of the affected nerve. QY, JX, HY http://en.volupedia.org/wiki/Morton%27s_neuroma 神经瘤 10049691 morton's neuroma AE This is an AE which is the inflammation of the ventricles in the cns brain. QY, JX, HY http://en.volupedia.org/wiki/Ventriculitis 中枢神经系统脑室炎 10009719 cns ventriculitis AE This is an AE which is to act in a way that is likely to elicit attention, usually to elicit validation from others. QY, JX, HY http://en.volupedia.org/wiki/Attention_seeking 寻求注意行为 10003739 attention-seeking behaviour AE This is an AE which refers to a set of brief unconscious behaviors. QY, JX, HY http://en.volupedia.org/wiki/Automatism_(medicine) 无意识行为 10003830 automatism AE This is an AE which repetitive unconscious gestures, such as lip smacking, in certain types of epilepsy. QY, JX, HY http://en.volupedia.org/wiki/Automatism 无意识癫痫行为 10003831 automatism epileptic AE This is an AE which is romantic attraction, sexual attraction or sexual behavior between persons of the opposite sex or gender. QY, JX, HY http://en.volupedia.org/wiki/Heterosexuality 异性恋 10061108 heterosexuality AE This is an AE which is the description of the activity that will increase the probability that a person engaging in sexual activity with another person infected with a sexually transmitted infection will be infected or become pregnant, or make a partner pregnant. QY, JX, HY http://en.volupedia.org/wiki/Risky_sexual_behavior 高危性行为 10020082 high risk sexual behaviour AE This is an AE which is a tendency to act on a whim, displaying behavior characterized by little or no forethought, reflection, or consideration of the consequences. QY, JX, HY http://en.volupedia.org/wiki/Impulsivity 冲动行为 10021567 impulsive behaviour AE This is an AE which is a sleep disorder in which people act out their dreams. QY, JX, HY http://en.volupedia.org/wiki/Rapid_eye_movement_sleep_behavior_disorder 快速眼动睡眠行为障碍 10077299 rapid eye movement sleep behaviour disorder AE This is an AE which significantly interferes with social engagement and characterises various psychopathologies. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32633192/ 社交回避行为 10041243 social avoidant behaviour AE This is an AE which is a disorder of the myelin sheath, which is a primary actor in the central nervous system and it also has herpes zoster. QY, JX, HY http://en.volupedia.org/wiki/Meningococcal_myelitis 带状疱疹脊髓脊膜炎 10074251 herpes zoster meningomyelitis AE This is an AE which is a generic term referring to a disorder in which a cyst or cavity forms within the spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Syringomyelia 脊髓积水 10020523 hydromyelia AE This is an AE which is an infectious disease occured post vaccine transmitted by fecal-oral contamination with lymphatic replication . QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32644370/ 脊髓灰质炎疫苗后 10057226 poliomyelitis post vaccine AE This is an AE which is a group of latent symptoms of poliomyelitis (polio), occurring at about a 25–40% rate (latest data greater than 80%). QY, JX, HY http://en.volupedia.org/wiki/Post-polio_syndrome 脊髓灰质炎后综合征 10036239 post polio syndrome AE This is an AE which is a common disease that most primary care doctors encounter . QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/29605415/ 脊髓疾病 10061367 spinal cord disorder AE This is an AE which is blood escaping from the circulatory system from damaged blood vessels on spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Bleeding 脊髓出血 10048992 spinal cord hemorrhage AE This is an AE which is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/31830940/ 脊髓梗塞 10058571 spinal cord infarction AE This is an AE which is spinal cord tissue death (necrosis) due to inadequate blood supply to the affected area. QY, JX, HY http://en.volupedia.org/wiki/Infarction 脊髓感染 10049654 spinal cord infection AE This is an AE which is damage to the spinal cord that causes temporary or permanent changes in its function. QY, JX, HY http://en.volupedia.org/wiki/Spinal_cord_injury?wprov=srpw1_0 脊髓损伤 10041552 spinal cord injury AE This is an AE which is damage to the cervical spinal cord that causes temporary or permanent changes in its function. QY, JX, HY http://en.volupedia.org/wiki/Spinal_cord_injury?wprov=srpw1_0 脊髓损伤颈椎 10041553 spinal cord injury cervical AE This is an AE which is damage to the lumbar spinal cord that causes temporary or permanent changes in its function. QY, JX, HY http://en.volupedia.org/wiki/Spinal_cord_injury?wprov=srpw1_0 脊髓损伤腰椎 10041555 spinal cord injury lumbar AE This is an AE which is a benign tumor made of fat tissue on the spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Lipoma 脊髓脂肪瘤 10064898 spinal cord lipoma AE This is an AE which is the build-up of fluid in the spinal cord tissue. QY, JX, HY http://en.volupedia.org/wiki/Edema 脊髓水肿 10063036 spinal cord edema AE This is an AE which is a loss of motor function in one or more spinal cord muscles. QY, JX, HY http://en.volupedia.org/wiki/Paralysis 脊髓麻痹 10057268 spinal cord paralysis AE This is an AE which is a non-surgical procedure intended to relieve pressure on the spinal cord or on one or more compressed nerve roots passing through or exiting the spinal column. QY, JX, HY http://en.volupedia.org/wiki/Spinal_decompression 脊柱减压 10041563 spinal decompression AE This is an AE which refers to a condition impairing the backbone. QY, JX, HY http://en.volupedia.org/wiki/Spinal_disease 脊柱畸形 10058907 spinal deformity AE This is an AE which refers to a condition impairing the backbone. QY, JX, HY http://en.volupedia.org/wiki/Spinal_disease 脊椎病 10061368 spinal disorder AE This is an AE which is a rare condition that usually presents with acute, severe pain at the location of the hemorrhage, with radiation to the extremities. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/20675642/ 脊髓硬膜外血肿 10050162 spinal epidural hematoma AE This is an AE which is an intervention performed on spinal articulations, synovial joints, which is asserted to be therapeutic. QY, JX, HY http://en.volupedia.org/wiki/Spinal_manipulation 脊椎推拿 10041578 spinal manipulation AE This is an AE which is a rare neuromuscular disorder that results in the loss of motor neurons and progressive muscle wasting. QY, JX, HY http://en.volupedia.org/wiki/Spinal_muscular_atrophy 脊髓性肌萎缩 10041582 spinal muscular atrophy AE This is an AE which is a type of radiographic examination that uses a contrast medium to detect pathology of the spinal cord, including the location of a spinal cord injury, cysts, and tumors. QY, JX, HY http://en.volupedia.org/wiki/Myelography 脊髓造影 10057563 spinal myelogram AE This is an AE which was first explored by Whytt in 1750 as a loss of sensation accompanied by motor paralysis with initial loss but gradual recovery of reflexes, following a spinal cord injury (SCI) – most often a complete transection. QY, JX, HY http://en.volupedia.org/wiki/Spinal_shock 脊髓休克 10049679 spinal shock AE This is an AE which is a generic term referring to a disorder in which a cyst or cavity forms within the spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Syringomyelia 脊髓空洞症 10042928 syringomyelia AE This is an AE which is inflammation caused by the viral of the spinal cord which can disrupt the normal responses from the brain to the rest of the body, and from the rest of the body to the brain. Inflammation in the spinal cord, can cause the myelin and axon to be damaged resulting in symptoms such as paralysis and sensory loss. QY, JX, HY http://en.volupedia.org/wiki/Myelitis 病毒性脊髓炎 10071763 viral myelitis AE This is an AE which is a serious condition of the spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Acute_flaccid_myelitis 急性弛缓性脊髓炎 10082097 acute flaccid myelitis AE This is an AE which is a neurodegenerative disease[a] that results in the progressive loss of motor neurons that control voluntary muscles. QY, JX, HY http://en.volupedia.org/wiki/Amyotrophic_lateral_sclerosis 肌萎缩性脊髓侧索硬化症 10002026 amyotrophic lateral sclerosis AE This is an AE which is a mass of cells (tumor) that lacks the ability to either invade neighboring tissue or metastasize (spread throughout the body) such as benign tumor of spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Benign_tumor 脊髓良性肿瘤 10004406 benign neoplasm of spinal cord AE This is an AE which is caused by damage to one half of the spinal cord, i.e. hemisection of the spinal cord resulting in paralysis and loss of proprioception on the same (or ipsilateral) side as the injury or lesion, and loss of pain and temperature sensation on the opposite (or contralateral) side as the lesion. QY, JX, HY http://en.volupedia.org/wiki/Brown-S%C3%A9quard_syndrome 脊髓半侧横断综合征 10006491 brown-sequard syndrome AE This is an AE which is the most common form of cervical spinal cord injury. QY, JX, HY http://en.volupedia.org/wiki/Central_cord_syndrome 中枢脊髓综合征 10054839 central cord syndrome AE This is an AE which describes any neurologic deficit related to the spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Myelopathy 颈锥脊髓病 10008289 cervical myelopathy AE This is an AE which is a term used to describe a constellation of early-appearing social communication deficits and repetitive sensory-motor behaviours associated with a strong genetic component as well as other causes. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30078460/ 自闭症谱系障碍 10063844 autism spectrum disorder AE This is an AE which is a condition which persists for more than 6 weeks in duration and occurs in the absence of an identifiable provoking factor. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30984191/ 自发慢性荨麻疹 10072757 chronic spontaneous urticaria AE This is an AE which is the experience in which an individual perceives the surrounding environment from a different perspective, from a position outside of their own body. QY, JX, HY http://en.volupedia.org/wiki/Autoscopy 自窥症；自见幻觉 10074080 autoscopy AE This is an AE which refers loss of the ability to read due to cerebral disorder. QY, JX, HY http://en.volupedia.org/wiki/Alexia 失读症 10001663 alexia AE This is an AE which is the inability to process sensory information. QY, JX, HY http://en.volupedia.org/wiki/Agnosia 失认症 10048663 agnosia AE This is an AE which is an acquired neurological disorder causing a loss in the ability to communicate through writing, either due to some form of motor dysfunction or an inability to spell. QY, JX, HY http://en.volupedia.org/wiki/Agraphia 失写症 10001508 agraphia AE This is an AE which is a deficit in memory caused by brain damage or disease, but it can also be caused temporarily by the use of various sedatives and hypnotic drugs. QY, JX, HY http://en.volupedia.org/wiki/Amnesia 失忆症 10061423 amnestic disorder AE This is an AE which is a mood disorder characterized by periods of depression and periods of abnormally-elevated mood that last from days to weeks each. QY, JX, HY http://en.volupedia.org/wiki/Bipolar_disorder 双相情感障碍 10057667 bipolar disorder AE This is an AE which is a bipolar spectrum disorder characterized by at least one episode of hypomania and at least one episode of major depression. QY, JX, HY http://en.volupedia.org/wiki/Bipolar_II_disorder 双相情感障碍ii型 10004940 bipolar ii disorder AE This is an AE which is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features. QY, JX, HY http://en.volupedia.org/wiki/Bipolar_I_disorder 双相情感障碍i型 10004939 bipolar i disorder AE This is an AE which is a condition of abnormally deep sleep or a stupor from which it is difficult to rouse. QY, JX, HY http://en.volupedia.org/wiki/Sopor_(sleep) 迷睡 10058709 sopor AE This is an AE which is the cumulative effect of not getting enough sleep. QY, JX, HY http://en.volupedia.org/wiki/Sleep_debt 睡眠不足 10080881 sleep deficit AE This is an AE which is a rare form of circadian rhythm sleep disorder. QY, JX, HY http://en.volupedia.org/wiki/Irregular_sleep%E2%80%93wake_rhythm 睡眠节律紊乱 10080301 irregular sleep wake rhythm disorder AE This is an AE which is a state, during waking up or falling asleep, in which a person is aware but unable to move or speak. QY, JX, HY http://en.volupedia.org/wiki/Sleep_paralysis 睡眠麻痹 10041002 sleep paralysis AE This is an AE which is a broad classification of sleeping disorders involving difficulty getting to sleep, remaining asleep, or of excessive sleepiness. QY, JX, HY http://en.volupedia.org/wiki/Dyssomnia 睡眠障碍 10061827 dyssomnia AE This is an AE which is characterized by reduced exercise capacity. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/31584302/ 慢性左心室衰竭 10063083 chronic left ventricular failure AE This is an AE which refers a chronic condition due to mental or physical impairments arising before adulthood. QY, JX, HY http://en.volupedia.org/wiki/Mental_disability 精神残疾 10027353 mental disability AE This is an AE which is a mental disorder characterized by continuous or relapsing episodes of psychosis. QY, JX, HY http://en.volupedia.org/wiki/Schizophrenia 精神分裂症 10039626 schizophrenia AE This is an AE which is a mental disorder diagnosed when symptoms of schizophrenia are present for a significant portion of time (at least a month), but signs of disturbance are not present for the full six months required for the diagnosis of schizophrenia. QY, JX, HY http://en.volupedia.org/wiki/Schizophreniform_disorder 精神分裂症 10039647 schizophreniform disorder AE This is an AE which is classified as “partial awakenings in which the state of consciousness remains impaired for several minutes without any accompanying major behavioural disorders or severe autonomic responses”. QY, JX, HY http://en.volupedia.org/wiki/Confusional_arousals 精神混乱的冲动 10067494 confusional arousal AE This is an AE which is an organically caused decline from a previous baseline mental functioning, that develops over a short period of time, typically hours to days. QY, JX, HY http://en.volupedia.org/wiki/Delirium 精神混乱的状态 10010305 confusional state AE This is an AE which is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. QY, JX, HY http://en.volupedia.org/wiki/Mental_disorder 精神疾病 10061284 mental disorder AE This is an AE which is a temporary inability to maintain optimal cognitive performance. QY, JX, HY http://en.volupedia.org/wiki/Fatigue#Mental 精神疲劳 10076757 mental fatigue AE This is an AE which is characterized by backward disequilibrium in a sitting and standing position, reactional hypertonia, an alteration of postural reactions, gait modifications, and fear of falling. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/15152732/ 精神运动不适应综合征 10080662 psychomotor disadaptation syndrome AE This is an AE which is a chronic disorder of the nervous system characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes. QY, JX, HY http://en.volupedia.org/wiki/Temporal_lobe_epilepsy 精神运动性癫痫发作 10037214 psychomotor seizures AE This is an AE which is a generalized neurodevelopmental disorder characterized by significantly impaired intellectual and adaptive functioning. QY, JX, HY http://en.volupedia.org/wiki/Intellectual_disability 精神障碍 10027374 mental impairment AE This is an AE which is an abnormal condition of the mind that results in difficulties determining what is real and what is not real. QY, JX, HY http://en.volupedia.org/wiki/Psychosis 精神症状 10079254 psychotic symptom AE This is an AE which is the action of violently shaking one's head in rhythm with music. QY, JX, HY http://en.volupedia.org/wiki/Headbanging 头部撞击 10019191 head banging AE This is an Ae which is a cutaneous fungal infection (dermatophytosis) of the scalp. QY, JX, HY http://en.volupedia.org/wiki/Tinea_capitis 头癣 10043866 tinea capitis AE This is an AE which may be a clinical manifestation of autonomic nervous system dysregulation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/12172243/ 头晕劳累型 10013576 dizziness exertional AE This is an AE which is characterized by having difficulty returning to sleep after waking up during the night or very early in the morning. QY, JX, HY http://en.volupedia.org/wiki/Middle-of-the-night_insomnia 中期失眠症 10027590 middle insomnia AE This is an AE which is a state of tiredness, weariness, fatigue, or lack of energy. QY, JX, HY http://en.volupedia.org/wiki/Lethargy 呆滞 10041052 sluggishness AE This is an AE which is a rare neurodegenerative disorder characterized by autonomic dysfunction, tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) and ataxia. QY, JX, HY http://en.volupedia.org/wiki/Multiple_system_atrophy 多系统萎缩 10064060 multiple system atrophy AE This is an AE which encompasses several types of dementia involving the frontal and temporal lobes.[3] FTDs are broadly presented as behavioral or language disorders. QY, JX, HY http://en.volupedia.org/wiki/Frontotemporal_dementia 额颞叶痴呆 10068968 frontotemporal dementia AE This is an AE which is an anxiety disorder in which an individual experiences excessive anxiety regarding separation from home and/or from people to whom the individual has a strong emotional attachment (e.g., a parent, caregiver, significant other, or siblings). QY, JX, HY http://en.volupedia.org/wiki/Separation_anxiety_disorder 分离焦虑症 10040045 separation anxiety disorder AE This is an AE which is a neurological examination finding elicited by a reflex test which can help verify the presence or absence of issues arising from the corticospinal tract. QY, JX, HY http://en.volupedia.org/wiki/Hoffmann%27s_reflex 霍夫曼氏征 10058444 hoffmann's sign AE This is an AE which is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily functions. QY, JX, HY http://en.volupedia.org/wiki/Dementia_with_Lewy_bodies 路易体痴呆 10067889 dementia with lewy bodies AE This is an AE which is a disorder of the central nervous system. QY, JX, HY http://en.volupedia.org/wiki/Neuroborreliosis 螺旋体病 10052057 neuroborreliosis AE This is an AE which is a common neurodevelopmental disorder that begins in childhood or adolescence. QY, JX, HY http://en.volupedia.org/wiki/Tourette_syndrome 图雷特氏症 10044126 tourette's disorder AE QY, JX, HY 感觉神经节炎 10066196 sensory ganglionitis AE QY, JX, HY 血管病性神经病变 10079036 angiopathic neuropathy AE QY, JX, HY 脊柱扁平化 10077756 spinal flattening AE QY, JX, HY 睡眠期节律紊乱 10041003 sleep phase rhythm disturbance AE QY, JX, HY 精神运动技能受损 10049215 psychomotor skills impaired AE This is an AE which is a disease characterized by a weeks-long course of thunderclap headaches, sometimes focal neurologic signs, and occasionally seizures. QY, JX, HY http://en.volupedia.org/wiki/Reversible_cerebral_vasoconstriction_syndrome 大脑血管收缩 10059109 cerebral vasoconstriction AE This is an AE which is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease with bacteraemia. QY, JX, HY http://en.volupedia.org/wiki/Neisseria_meningitidis 脑膜炎球菌菌血症 10058858 meningococcal bacteremia AE This is an AE which is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease with carditis. QY, JX, HY http://en.volupedia.org/wiki/Neisseria_meningitidis 脑膜炎球菌性心炎 10027270 meningococcal carditis AE This is an AE which is a medical condition in which poor spinal blood flow to the brain causes cell death. QY, JX, HY http://en.volupedia.org/wiki/Stroke 脊柱中风 10082031 spinal stroke AE This is an AE which is a neurological condition in which the cerebellum is smaller than usual or not completely developed. QY, JX, HY http://en.volupedia.org/wiki/Cerebellar_hypoplasia_(non-human) 继发性小脑变性 10074943 secondary cerebellar degeneration AE This is an AE which is a perceptual disturbance experienced by some with epilepsy or migraine. QY, JX, HY http://en.volupedia.org/wiki/Aura_(symptom) 癫痫先兆 10015049 epileptic aura AE This is an AE which is a rare form of chronic, progressive brain inflammation caused by slow infection with certain defective strains of hypermutated measles virus. QY, JX, HY http://en.volupedia.org/wiki/Subacute_sclerosing_panencephalitis 全脑炎 10056332 panencephalitis AE This is an AE which is a relatively frequent occurrence in significant head trauma, and their detection is important, as even linear nondisplaced fractures can be associated with critical complications. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25086806/ 颅底骨折 10040960 skull fractured base AE This is an AE which is achieved in this model by injecting particles like blood clots (thrombembolic MCAO) or artificial spheres into the carotid artery of animals as an animal model of ischemic stroke. QY, JX, HY http://en.volupedia.org/wiki/Animal_model_of_ischemic_stroke#Embolic_middle_cerebral_artery_occlusion 脑动脉闭塞 10008089 cerebral artery occlusion AE This is an AE which is an abnormal narrowing in a cerebrovascular blood vessel or other tubular organ or structure such as foramina and canals. QY, JX, HY http://en.volupedia.org/wiki/Stenosis 脑血管狭窄 10061751 cerebrovascular stenosis AE This is an AE which is an acute inflammation of the protective membranes covering the brain and spinal cord caused by staphylococcal. QY, JX, HY http://en.volupedia.org/wiki/Meningitis 葡萄球菌脑膜炎 10027255 meningitis staphylococcal AE This is an AE which is an important and common complication of chimeric antigen receptor-T cell therapies. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30387077/ 中毒性脑炎 10014607 encephalitis toxic AE This is an AE which is associated with infectious complications, whereas emerging treatments, including anakinra and tocilizumab, may also result in increased susceptibility to certain infections. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/31021956/ 免疫介导性脑炎 10083074 immune-mediated encephalitis AE This is an AE which is characterized by macrocephaly and typical neuroimaging findings, is considered as a self-limiting condition and is therefore rarely treated in infants. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21647596/ 外部性脑积水 10076670 external hydrocephalus AE This is an AE which is defined as inflammation of the meninges, in almost all cases identified by an abnormal number of white blood cells in the cerebrospinal fluid and specific clinical signs/symptoms. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/23958365/ 脑膜病 10061281 meningeal disorder AE This is an AE which is five main reasons for bacterial, viral, fungal, protozoal, and prionic. QY, JX, HY http://en.volupedia.org/wiki/List_of_infections_of_the_central_nervous_system 颅内感染 10082062 intracranial infection AE This is an AE which is inflammation with haemorrhagic of the brain. QY, JX, HY http://en.volupedia.org/wiki/Encephalitis 脑炎出血 10014589 encephalitis haemorrhagic AE This is an AE which is inflammation and allergy of the brain. QY, JX, HY http://en.volupedia.org/wiki/Encephalitis 脑炎过敏 10056387 encephalitis allergic AE This is an AE which is inflammation and infection of the brain. QY, JX, HY http://en.volupedia.org/wiki/Encephalitis 脑炎的感染 10058805 encephalitis infection AE This is an AE which is inflammation of the brain caused by meningococcal. QY, JX, HY http://en.volupedia.org/wiki/Encephalitis 脑膜炎球菌脑炎 10014597 encephalitis meningococcal AE This is an AE which is recognised as a central factor in the development of many neurological disorders, but much less is known about the role of the blood-brain barrier in psychiatric disorders. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28781208/ 血脑屏障缺陷 10057361 blood brain barrier defect AE This is an AE which is the effect of a intracranial growing mass that results in secondary pathological effects by pushing on or displacing surrounding tissue. QY, JX, HY http://en.volupedia.org/wiki/Mass_effect_(medicine) 颅内肿块 10077667 intracranial mass AE This is an AE which may refer to an abnormal growth that usually appears on a baby's neck or head. QY, JX, HY http://en.volupedia.org/wiki/Cystic_hygroma 脑水囊瘤 10052370 cerebral hygroma AE This is an AE which means any allergic disorder or disease of the brain, especially chronic degenerative conditions. QY, JX, HY http://en.volupedia.org/wiki/Encephalopathy 过敏性脑病 10014627 encephalopathy allergic AE This is an AE which presents with symptoms of nausea, vomiting, and dizziness and thus mimics benign conditions such as viral gastroenteritis or labyrinthitis. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25439292/ 栓塞性小脑梗死 10084072 embolic cerebellar infarction AE This is an AE which refers a protein encoded by the gene NODAL and responsible for left-right asymmetry. QY, JX, HY http://en.volupedia.org/wiki/Nodal 结性节律 10029470 nodal rhythm AE This is an AE which refers to head was lacking in comfort. QY, JX, HY http://en.volupedia.org/wiki/Comfort 头部不适 10019194 head discomfort AE This is an AE which which occurs a few weeks after recovery from influenza is thought to be an autoimmune process associated with demyelination and vasculopathy. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/9316161/ 流感性脑炎 10058094 encephalitis influenzal AE This is an AE which is the thickening, hardening, and loss of elasticity of the walls of arteries. QY, JX, HY http://en.volupedia.org/wiki/Arteriosclerosis 脑部动脉硬化 10065559 cerebral arterio sclerosis AE This is an AE whichis vasculitis (inflammation of the blood vessel wall) involving the brain and occasionally the spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_vasculitis 脑部动脉炎 10008087 cerebral arteritis AE This is an AE which is an abnormal narrowing in a cerebral artery blood vessel or other tubular organ or structure such as foramina and canals. QY, JX, HY http://en.volupedia.org/wiki/Stenosis 脑部动脉狭窄 10063648 cerebral artery stenosis AE This is an AE which is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in eye movements. QY, JX, HY http://en.volupedia.org/wiki/Ataxia 脑性共济失调 10050389 cerebral ataxia AE This is an AE which is a common feature of many of the diseases that affect the brain. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_atrophy 脑部萎缩 10008096 cerebral atrophy AE This is an AE which is the accumulation of calcium salts in a cerebral body tissue. QY, JX, HY http://en.volupedia.org/wiki/Calcification 脑部钙化 10066296 cerebral calcification AE This is an AE which is defined as a general or specific failure of the circulation, either cardiac. QY, JX, HY http://en.volupedia.org/wiki/Circulatory_collapse 脑部循环衰竭 10008097 cerebral circulatory failure AE This is an AE which may refer to heart failure resulting in congestion in one or more organs. QY, JX, HY http://en.volupedia.org/wiki/Congestion 脑部堵塞 10076929 cerebral congestion AE This is an AE which is a cerebral closed sac, having a distinct envelope and division compared with the nearby tissue. QY, JX, HY http://en.volupedia.org/wiki/Cyst 脑部囊肿 10061445 cerebral cyst AE This is an AE which is a medical condition caused by dissolved gases emerging from solution as bubbles inside the cerebral body tissues during decompression. QY, JX, HY http://en.volupedia.org/wiki/Decompression_sickness 大脑减压 10052940 cerebral decompression AE This is an AE which may refer to relating to the brain disease. QY, JX, HY http://en.volupedia.org/wiki/Cerebral 脑部疾病 10054938 cerebral disorder AE This is an AE which is a form of dysgenesis in adults that alters the size and shape of their cells that lead to abnormal development. QY, JX, HY http://en.volupedia.org/wiki/Dysgenesis_(embryology) 脑发育不全 10056467 cerebral dysgenesis AE This is an AE which is a localized bleeding outside of cerebral blood vessels, due to either disease or trauma including injury or surgery and may involve blood continuing to seep from broken capillaries. QY, JX, HY http://en.volupedia.org/wiki/Hematoma 脑部血肿 10053942 cerebral hematoma AE This is an AE which is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. QY, JX, HY http://en.volupedia.org/wiki/Intracerebral_hemorrhage 脑出血 10008111 cerebral hemorrhage AE This is an AE which is a sudden bleeding into the tissues of the brain occured on foetal, into its ventricles, or into both. QY, JX, HY http://en.volupedia.org/wiki/Intracerebral_hemorrhage 脑出血胎儿 10050157 cerebral hemorrhage foetal AE This is an AE which is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when the brain is completely deprived of oxygen, it is called cerebral anoxia. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_hypoxia 脑灌注不足 10065384 cerebral hypoperfusion AE This is an AE which is mainly found in patients with Alzheimer's disease and lacunar infarction, and becomes one of the main reasons of death and disability in diabetic patients. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28822176/ 脑微血管病 10067466 cerebral microangiopathy AE This is an AE which is abnormal differences seen in magnetic resonance imaging of the brain of Alzheimer's disease patients, associated with amyloid-modifying therapies, particularly human monoclonal antibodies. QY, JX, HY http://en.volupedia.org/wiki/Amyloid-related_imaging_abnormalities 脑微出血 10067277 cerebral microhemorrhage AE This is an AE which refers to a group of pathological processes with various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain with ischaemic. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/20610345/ 脑小血管缺血性疾病 10070878 cerebral small vessel ischemic disease AE This is an AE which is the final product of the blood coagulation step in hemostasis on cerebral. QY, JX, HY http://en.volupedia.org/wiki/Thrombus 脑血栓形成 10008132 cerebral thrombosis AE This is an AE which is a parasitic disease caused by Toxoplasma gondii, an apicomplexan. QY, JX, HY http://en.volupedia.org/wiki/Toxoplasmosis 脑弓形体病 10057854 cerebral toxoplasmosis AE This is an AE which is the presence of a blood clot in the dural venous sinuses (which drain blood from the brain), the cerebral veins, or both. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_venous_sinus_thrombosis 脑静脉窦血栓形成 10083037 cerebral venous sinus thrombosis AE This is an AE which can refer to various forms of transient loss of consciousness caused by cerebral ventricle such as syncope, or loss of postural muscle tone without loss of consciousness . QY, JX, HY http://en.volupedia.org/wiki/Collapse 脑心室塌陷 10073706 cerebral ventricle collapse AE This is an AE which is defined as dilation of the fetal cerebral ventricles and is a relatively common finding on prenatal ultrasound. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/29705191/ 脑室扩张 10048824 cerebral ventricle dilatation AE This is an AE which is a rare congenital disorder characterized by the reduction or absence of functional peroxisomes in the cells of an individual. QY, JX, HY http://en.volupedia.org/wiki/Zellweger_syndrome 脑肝肾综合征 10053684 cerebrohepatorenal syndrome AE This is an AE which is a medical condition in which poor blood flow to the brain causes cell death. QY, JX, HY http://en.volupedia.org/wiki/Stroke 脑血管中风 10008190 cerebrovascular accident AE This is an AE which is an abnormal cerebrovascular connection between arteries and veins, bypassing the capillary system. QY, JX, HY http://en.volupedia.org/wiki/Arteriovenous_malformation 脑血管动静脉畸形 10056371 cerebrovascular arteriovenous malformation AE This is an AE which includes a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation. QY, JX, HY http://en.volupedia.org/wiki/Cerebrovascular_disease 脑血管疾病 10008196 cerebrovascular disorder AE This is an AE which includes a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation. QY, JX, HY http://en.volupedia.org/wiki/Cerebrovascular_disease 脑血管机能不全 10058842 cerebrovascular insufficiency AE This is an AE which is a common CNS manifestation of mitochondrial disorders (MIDs) and has been reported in specific and non-specific MIDs. QY, JX, HY https://link.springer.com/article/10.1007%2Fs11011-018-0238-y 小脑萎缩 10008027 cerebellar atrophy AE This is an AE which is the lodging of an embolus, a blockage-causing piece of material, inside a cerebellar blood vessel. QY, JX, HY http://en.volupedia.org/wiki/Embolism 小脑栓塞 10067167 cerebellar embolism AE This is an AE which accounts for 5-10% of all intracerebral haemorrhages and leads to severe, long-lasting functional deficits. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28318366/ 小脑出血 10008030 cerebellar hemorrhage AE This is an AE which is characterized by reduced cerebellar volume, even though cerebellar shape is (near) normal. QY, JX, HY http://en.volupedia.org/wiki/Cerebellar_hypoplasia 小脑发育不全 10008033 cerebellar hypoplasia AE This is an AE which is an important cause of stroke that often presents with common and non-specific symptoms such as dizziness, nausea and vomiting, unsteady gait, and headache. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/18848314/ 小脑梗死 10008034 cerebellar infarction AE This is an AE which may present in a completely different way from common stroke syndromes in the anterior cerebral circulation and can initially mimic benign vestibular neuritis and may later deteriorate into a life-threatening neurologic state. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/29891068/ 小脑卒中 10079062 cerebellar stroke AE This is an AE which is a type of abnormal and excessive growth of cerebellar tissue. QY, JX, HY http://en.volupedia.org/wiki/Neoplasm 小脑肿瘤 10061750 cerebellar tumor AE This is an AE which is an abscess caused by inflammation and collection of infected material, coming from local (ear infection, dental abscess, infection of paranasal sinuses, infection of the mastoid air cells of the temporal bone, epidural abscess) or remote (lung, heart, kidney etc.) infectious sources, within the brain tissue. QY, JX, HY http://en.volupedia.org/wiki/Brain_abscess 脑脓肿 10006105 brain abscess AE This is an AE which is a bruise of the brain tissue and can be associated with multiple microhemorrhages, small blood vessel leaks into brain tissue. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_contusion 脑挫伤 10052346 brain contusion AE This is an AE which is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when the brain is completely deprived of oxygen, it is called cerebral anoxia. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_hypoxia 大脑缺氧 10006127 brain hypoxia AE This is an AE which is an abnormality of the structure of brain. QY, JX, HY http://en.volupedia.org/wiki/Birth_defect#congenital_malformation 大脑畸形 10048409 brain malformation AE This is an AE which is an important feature that can be measured using various imaging modalities including X-ray, ultrasound, computed tomography, and magnetic resonance imaging. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/29849536/ 大脑中线移位 10069551 brain midline shift AE This is an AE which occurs when abnormal cells form within the brain. QY, JX, HY http://en.volupedia.org/wiki/Brain_tumor 脑部肿瘤 10061019 brain neoplasm AE This is an AE which is a mass of brain cells (tumor) that lacks the ability to either invade neighboring tissue or metastasize (spread throughout the body). QY, JX, HY http://en.volupedia.org/wiki/Benign_tumor 良性大脑肿瘤 10006129 brain neoplasm benign AE This is an AE which is commonly called brain cancer and they invade and destroy the surrounding tissue, may form metastases and, if untreated or unresponsive to treatment, will generally prove fatal. QY, JX, HY http://en.volupedia.org/wiki/Neoplasm 恶性大脑肿瘤 10006131 brain neoplasm malignant AE This is an AE which is excess accumulation of fluid (edema) in the intracellular or extracellular spaces of the brain. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_edema 脑部水肿 10048962 brain edema AE This is an AE which is an auditory evoked potential extracted from ongoing electrical activity in the brain and recorded via electrodes placed on the scalp. QY, JX, HY http://en.volupedia.org/wiki/Auditory_brainstem_response 脑干听觉诱发反应 10049507 brain stem auditory evoked response AE This is an AE which falls under the broader category of stroke syndromes, or specific symptoms caused by vascular injury to an area of brain (for example, the lacunar syndromes). QY, JX, HY http://en.volupedia.org/wiki/Brainstem_stroke_syndrome 脑干中风 10068644 brain stem stroke AE This is an AE which is most commonly due to occlusion of the posterior circulation or mass effect from intrinsic space-occupying lesions. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/31283463/ 脑干综合症 10063292 brain stem syndrome AE This is an AE which is a hemorrhage of blood between the skull and the periosteum of any age human, including a newborn baby secondary to rupture of blood vessels crossing the periosteum. QY, JX, HY http://en.volupedia.org/wiki/Cephalohematoma 头颅血肿 10008014 cephal hematoma AE This is an AE which is a major abnormality in the shape of head compared to the normal shape of that part. QY, JX, HY http://en.volupedia.org/wiki/Deformity 头畸形 10061199 head deformity AE This is an AE which is related to medical factors and early neurobehavior, but it may not be a good predictor of outcome when used in isolation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/26709421/ 头滞后 10057870 head lag AE This is an AE which is tremor of the head and is of cerebellar origin. QY, JX, HY http://en.volupedia.org/wiki/Tremor#Titubation 摇头 10064950 head titubation AE This is an AE which is a condition in which circumference of the human head is abnormally large. QY, JX, HY http://en.volupedia.org/wiki/Macrocephaly 大头畸形 10050183 macrocephaly AE This is an AE which is a medical condition involving a smaller-than-normal head and may be present at birth or it may develop in the first few years of life. QY, JX, HY http://en.volupedia.org/wiki/Microcephaly 小脑症 10068320 microencephaly AE This is an AE which is a medical condition involving a smaller-than-normal head and may be present at birth or it may develop in the first few years of life. QY, JX, HY http://en.volupedia.org/wiki/Microcephaly 小头畸形 10027534 microcephaly AE This is an AE which is a condition characterized by an asymmetrical distortion (flattening of one side) of the skull. QY, JX, HY http://en.volupedia.org/wiki/Plagiocephaly 斜头畸形 10048586 plagiocephaly AE This is an AE which is an asymmetric deformation of skull due to various reasons; first birth, assisted labor, multiple pregnancy, prematurity, congenital muscular torticollis and position of head. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32380806/ 位置斜头畸形 10068711 positional plagiocephaly AE This is an AE which is a condition that affects the development of the human brain by multiple small gyri (microgyri) creating excessive folding of the brain leading to an abnormally thick cortex. QY, JX, HY http://en.volupedia.org/wiki/Polymicrogyria 多小脑回 10073489 polymicrogyria AE This is an AE which is a progressive, degenerative, genetic disease with multiple types, each of which could be considered a neurological condition in its own right. QY, JX, HY 脊髓小脑性共济失调 10057660 spino cerebellar ataxia AE This is an AE whichis a diverse group of rare, slowly progressive, neurological diseases, often inherited but of incompletely understood pathophysiology, which affect the cerebellum and its related pathways. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/14521474/ 脊髓小脑疾病 10061551 spino cerebellar disorder AE This is an AE which is a rare childhood neurological syndrome and is characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram (EEG). QY, JX, HY http://en.volupedia.org/wiki/Landau%E2%80%93Kleffner_syndrome 获得性癫痫性失语 10052075 acquired epileptic aphasia AE This is an AE which is an inability to comprehend or formulate language because of damage to specific brain regions. QY, JX, HY http://en.volupedia.org/wiki/Aphasia 失语症 10002948 aphasia AE This is an AE which is a type of severe heat illness that results in a body temperature greater than 40.0 °C (104.0 °F). QY, JX, HY http://en.volupedia.org/wiki/Heat_stroke 热射病 10019345 heat stroke AE This is an AE which is the most common type of ischaemic stroke, resulting from the occlusion of small penetrating arteries that provide blood to the brain's deep structures. QY, JX, HY http://en.volupedia.org/wiki/Lacunar_stroke 腔隙性中风 10076994 lacunar stroke AE This is an AE which is sudden damage to the brain caused by a blow or jolt and it has one of the highest mortality and disability rates in the world. QY, JX, HY https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607269/ 颅脑损伤 10070976 craniocerebral injury AE This is an AE which is a condition in which one or more of the fibrous sutures in a young infant's skull prematurely fuses by turning into bone (ossification), thereby changing the growth pattern of the skull. QY, JX, HY http://en.volupedia.org/wiki/Craniosynostosis 颅缝早闭 10049889 craniosynostosis AE This is an AE which is a break in one or more of the eight bones that form the cranial portion of the skull, usually occurring as a result of blunt force trauma. QY, JX, HY http://en.volupedia.org/wiki/Skull_fracture 颅骨骨折 10061365 skull fracture AE This is an AE which is bicoronal craniosynostosis is characterized by a wide, short skull. QY, JX, HY http://en.volupedia.org/wiki/Carpenter_syndrome 颅骨畸形 10062348 skull malformation AE This is an AE which is encephalitis due to herpes simplex virus. QY, JX, HY http://en.volupedia.org/wiki/Herpesviral_encephalitis 单纯疱疹性脑炎 10019953 herpes simplex encephalitis AE This is an AE which is meningitis associated with herpes simplex virus (HSV). QY, JX, HY http://en.volupedia.org/wiki/Herpesviral_meningitis 单纯疱疹性脑膜炎 10019956 herpes simplex meningitis AE This is an AE which is a medical condition that simultaneously resembles both meningitis, which is an infection or inflammation of the meninges, and encephalitis, which is an infection or inflammation of the brain. QY, JX, HY http://en.volupedia.org/wiki/Meningoencephalitis 单纯疱疹性脑膜脑炎 10074247 herpes simplex meningo encephalitis AE This is an AE which is characterized by recurrent clinical seizures and prominent interictal epileptiform discharges seen during the early infantile period. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/26271793/ 癫痫性脑病 10077380 epileptic encephalopathy AE This is an AE which is a type of meningitis due to a herprs zoster infection. QY, JX, HY http://en.volupedia.org/wiki/Viral_meningitis 带状疱疹脑膜炎 10074259 herpes zoster meningitis AE This is an AE which is a medical condition that simultaneously resembles both meningitis, which is an infection or inflammation of the meninges, and encephalitis, which is an infection or inflammation of the brain. QY, JX, HY http://en.volupedia.org/wiki/Meningoencephalitis 带状疱疹脑膜脑炎 10074248 herpes zoster meningo encephalitis AE This is an AE which is tissue death (necrosis) due to inadequate blood supply to the affected area. QY, JX, HY http://en.volupedia.org/wiki/Infarction 脑梗死 10061216 infarction AE This is an AE which is a particular abnormal change in appearance of white matter near the lateral ventricles. QY, JX, HY http://en.volupedia.org/wiki/Leukoaraiosis 脑白质疏松症 10051765 leukoaraiosis AE This is an AE which is a group of usually inherited disorders characterized by degeneration of the white matter in the brain. QY, JX, HY http://en.volupedia.org/wiki/Leukodystrophy 脑白质营养不良 10024381 leukodystrophy AE This is an AE which is a form of encephalitis, a disease characterized by inflammation of the brain. QY, JX, HY http://en.volupedia.org/wiki/Limbic_encephalitis 边缘脑炎 10078012 limbic encephalitis AE This is an AE which is the three membranes that envelop the brain and spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Meninges 脑膜肿瘤 10061282 meningeal neoplasm AE This is an AE which is typically a slow-growing tumor that forms from the meninges, the membranous layers surrounding the brain and spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Meningioma 脑膜瘤 10027191 meningioma AE This is an AE which is a set of symptoms similar to those of meningitis but not caused by meningitis. QY, JX, HY http://en.volupedia.org/wiki/Meningism 假性脑膜炎 10027192 meningism AE This is an AE which is usually lethal unless appropriate antibiotics that cross the blood-brain barrier are given. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30273239/ 细菌性脑膜炎 10027202 meningitis bacterial AE This is an AE which is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and brain, where it appears as a meningitis. QY, JX, HY http://en.volupedia.org/wiki/Cryptococcosis 隐球菌脑膜炎 10027209 meningitis cryptococcal AE This is an AE which is a form of bacterial meningitis caused by the Haemophilus influenzae bacteria. QY, JX, HY http://en.volupedia.org/wiki/Haemophilus_meningitis 嗜血杆菌脑膜炎 10027241 meningitis haemophilus AE This is an AE which is an acute inflammation of the protective membranes covering the brain and spinal cord caused by herps. QY, JX, HY http://en.volupedia.org/wiki/Meningitis 脑膜炎疱疹 10027242 meningitis herpes AE This is an AE which is a form of bacterial meningitis. QY, JX, HY http://en.volupedia.org/wiki/Meningococcal_disease#Meningitis 脑膜炎球菌性脑膜炎 10027249 meningitis meningococcal AE This is an AE which is a viral disease caused by the mumps virus and complications include deafness and a wide range of inflammatory conditions, of which inflammation of the meninges. QY, JX, HY http://en.volupedia.org/wiki/Mumps 脑膜炎腮腺炎 10027250 meningitis mumps AE This is an AE which is a serious medical condition in infants that is rapidly fatal if untreated. QY, JX, HY http://en.volupedia.org/wiki/Neonatal_meningitis 新生儿脑膜炎 10058780 meningitis neonatal AE This is an AE which continues to be associated with high rates of mortality and long-term neurological sequelae and the most common route of infection starts by nasopharyngeal colonization by Streptococcus pneumoniae, which must avoid mucosal entrapment and evade the host immune system after local activation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21734248/ 肺炎球菌脑膜炎 10027253 meningitis pneumococcal AE This is an AE which is a symptomatic meningitis infection caused by bacteria of the Salmonella type . QY, JX, HY http://en.volupedia.org/wiki/Salmonellosis 沙门氏菌脑膜炎 10027254 meningitis salmonella AE This is an AE which is a specific type of bacterial meningitis caused by the Mycobacterium tuberculosis infection of the meninges—the system of membranes which envelop the central nervous system. QY, JX, HY http://en.volupedia.org/wiki/Tuberculous_meningitis 结核性脑膜炎 10027259 meningitis tuberculous AE This is an AE which is a type of meningitis due to a viral infection and it results in inflammation of the meninges. QY, JX, HY http://en.volupedia.org/wiki/Viral_meningitis 病毒性脑膜炎 10027260 meningitis viral AE This is an AE which is a birth defect in which there is incomplete closing of the spine and the membranes around the spinal cord during early development in pregnancy. QY, JX, HY http://en.volupedia.org/wiki/Spina_bifida 脑脊膜突出 10027266 meningocele AE This is an AE which is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. QY, JX, HY http://en.volupedia.org/wiki/Neisseria_meningitidis 脑膜炎球菌感染 10027274 meningococcal infection AE This is an AE which describes infections caused by the bacterium Neisseria meningitidis. QY, JX, HY http://en.volupedia.org/wiki/Meningococcal_disease 脑膜炎球菌败血症 10027280 meningococcal sepsis AE This is an AE which is meningitis associated with herpes simplex virus (HSV). QY, JX, HY http://en.volupedia.org/wiki/Herpesviral_meningitis 脑膜脑炎疱疹 10027285 meningo encephalitis herpetic AE This is an AE which is a birth defect in which there is incomplete closing of the spine and the membranes around the spinal cord during early development in pregnancy. QY, JX, HY http://en.volupedia.org/wiki/Spina_bifida 脑脊膜脊髓膨出 10027287 meningomyelocele AE This is an AE which is a lysosomal storage disease which is commonly listed in the family of leukodystrophies as well as among the sphingolipidoses as it affects the metabolism of sphingolipids. QY, JX, HY http://en.volupedia.org/wiki/Metachromatic_leukodystrophy 异染性脑白质营养不良 10067609 metachromatic leukodystrophy AE This is an AE which refers to any syndrome or disorder of mental function whose cause is alleged to be known as organic (physiologic) rather than purely of the mind. QY, JX, HY http://en.volupedia.org/wiki/Organic_brain_syndrome 器质性脑综合征 10031077 organic brain syndrome AE This is an AE which is a fibrosing and inflammatory process, which involves the dura mater. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28413094/ 硬脑膜炎 10053658 pachymeningitis AE This is an AE which is a form of encephalomyopathy that is associated with a mitochondrial disease. QY, JX, HY http://en.volupedia.org/wiki/Mitochondrial_encephalomyopathy 线粒体脑肌病 10058799 mitochondrial encephalomyopathy AE This is an AE which represents a syndrome of temporary or permanent disturbance of brain functions that occurs in different diseases and varies in clinical presentation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28084256/ 代谢脑病 10062190 metabolic encephalopathy AE This is an AE which is a hyperacute and frequently fatal form of ADEM. QY, JX, HY http://en.volupedia.org/wiki/Acute_disseminated_encephalomyelitis#Acute_hemorrhagic_leukoencephalitis 白质脑脊髓炎 10048999 leuko encephalo myelitis AE This is an AE which is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when the brain is completely deprived of oxygen, it is called cerebral anoxia. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_hypoxia 缺氧性脑病变 10021147 hypoxic encephalopathy AE This is an AE which is a neural tube defect characterized by sac-like protrusions of the brain and the membranes that cover it through openings in the skull. QY, JX, HY http://en.volupedia.org/wiki/Encephalocele 脑膨出 10014617 encephalo cele AE This is an AE which is a localized softening of the substance of the brain, due to bleeding or inflammation. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_softening 脑软化 10051818 encephalo malacia AE This is an AE which is inflammation of the brain and spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Encephalomyelitis 脑脊髓炎 10014619 encephalo myelitis AE This is an AE which is defined by signs and symptoms of abnormal neurological function in the first few days of life in an infant born at term. QY, JX, HY http://en.volupedia.org/wiki/Neonatal_encephalopathy 脑病新生儿 10014633 encephalopathy neonatal AE This is an AE which is a type of encephalitis that can result from a number of autoimmune diseases. QY, JX, HY http://en.volupedia.org/wiki/Autoimmune_encephalitis 自身免疫性脑炎 10072378 encephalitis autoimmune AE This is an AE which defines as an illness characterized by myoclonus, ataxia, nystagmus, oculomotor palsies, and bulbar palsy in various combinations, with or without neuroimaging. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/22956971/ 脑干脑炎 10048997 encephalitis brain stem AE This is an AE which is discovered in Kern County, California and causes encephalitis in humans. QY, JX, HY http://en.volupedia.org/wiki/California_encephalitis_orthobunyavirus 加州脑炎 10014584 encephalitis california AE This is an AE which is an important opportunistic infection in HIV-infected patients but is rarely recognized in other groups. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/8815757/ 脑炎巨细胞病毒 10014586 encephalitis cytomegalovirus AE This is an AE which is defined by the presence of an inflammatory process of the brain in association with clinical evidence of neurologic dysfunction caused by enteroviral. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25175874/ 肠病毒性脑炎 10063946 encephalitis enteroviral AE This is an AE which is encephalitis due to herpes simplex virus. QY, JX, HY http://en.volupedia.org/wiki/Herpesviral_encephalitis 脑炎疱疹 10014590 encephalitis herpes AE This is an AE which is an infection of the brain caused by the Japanese encephalitis virus (JEV). QY, JX, HY http://en.volupedia.org/wiki/Japanese_encephalitis 日本乙型脑炎 10014596 encephalitis japanese b AE This is an AE which is an atypical form of encephalitis. QY, JX, HY http://en.volupedia.org/wiki/Encephalitis_lethargica 埃科诺莫氏病 10052369 encephalitis lethargica AE This is an AE which is a viral disease caused by the mumps virus and may occur encephalitis. QY, JX, HY http://en.volupedia.org/wiki/Mumps 脑炎流行性腮腺炎 10014598 encephalitis mumps AE This is an AE which is inflammation of the brain parenchyma, called encephalitis, by a virus. QY, JX, HY http://en.volupedia.org/wiki/Viral_encephalitis 病毒性脑炎 10014612 encephalitis viral AE This is an AE which is a brain injury in which scattered lesions occur over a widespread area in white matter tracts as well as grey matter. QY, JX, HY http://en.volupedia.org/wiki/Diffuse_axonal_injury 脑弥漫性轴索损伤 10066213 diffuse axonal injury AE This is an AE which is a rare endocrine condition featuring a low blood sodium concentration and dehydration in response to injury (trauma) or the presence of tumors in or surrounding the brain. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_salt-wasting_syndrome 脑性盐耗综合征 10078827 csws syndrome AE This is an AE which is a head injury that temporarily affects brain functioning. QY, JX, HY http://en.volupedia.org/wiki/Concussion 脑震荡 10010254 concussion AE This is an AE which is the pathologic process that results in an area of necrotic tissue in the brain (cerebral infarct) with embolic. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_infarction 栓塞性脑梗死 10060839 embolic cerebral infarction AE This is an AE which is a neurological condition characterized by encephalopathy, thyroid autoimmunity, and good clinical response to corticosteroids. QY, JX, HY http://en.volupedia.org/wiki/Hashimoto%27s_encephalopathy 桥本脑病 10069432 hashimoto's encephalopathy AE This is an AE which is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres. QY, JX, HY http://en.volupedia.org/wiki/Holoprosencephaly 前脑无裂畸形 10056304 holoprosencephaly AE This is an AE which is the common collective name for human betaherpesvirus 6A (HHV-6A) and human betaherpesvirus 6B (HHV-6B) and can be associated with encephalitis in the case of immunocompromised patients. QY, JX, HY http://en.volupedia.org/wiki/Human_herpesvirus_6 人疱疹病毒脑炎 10081897 human herpesvirus 6 encephalitis AE This is an AE which is a syndrome (a set of signs and symptoms) with encephalomyelitis that is the consequence of cancer in the body, specifically due to the production of chemical signaling molecules (such as hormones or cytokines) by tumor cells or by an immune response against the tumor. QY, JX, HY http://en.volupedia.org/wiki/Paraneoplastic_syndrome 脑脊髓脑炎 10069587 paraneoplastic encephalomyelitis AE This is an AE which can result from neonatal encephalopathy and perinatal arterial ischaemic stroke, usually at term, but also in preterm infants. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25686754/ 围产期脑损伤 10056392 perinatal brain damage AE This is an AE which is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles. QY, JX, HY http://en.volupedia.org/wiki/Periventricular_leukomalacia 室周的脑栓塞 10052594 periventricular leukomalacia AE This is an AE which is a set of symptoms that may continue for weeks, months, or a year or more after a concussion – a mild form of traumatic brain injury (TBI). QY, JX, HY http://en.volupedia.org/wiki/Post-concussion_syndrome 脑震荡综合征 10057230 post concussion syndrome AE This is an AE which is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater cyanobacteria crusts. QY, JX, HY http://en.volupedia.org/wiki/Toxic_encephalopathy 中毒性脑病 10044221 toxic encephalopathy AE This is an AE which is a rare condition that is characterized by progressive damage (-pathy) to white matter (-leuko-) in the brain (-encephalo-), particularly myelin, due to causes such as exposure to substance use, environmental toxins, or chemotherapeutic drugs. QY, JX, HY http://en.volupedia.org/wiki/Toxic_leukoencephalopathy 中毒性白质脑病 10075528 toxic leukoencephalopathy AE This is an AE which is a hyperacute and frequently fatal form of acute disseminated encephalomyelitis(ADEM). QY, JX, HY http://en.volupedia.org/wiki/Acute_disseminated_encephalomyelitis#Acute_hemorrhagic_leukoencephalitis 急性出血性白细胞脑炎 10058994 acute haemorrhagic leukoencephalitis AE This is an AE which is an acute inflammation of the protective membranes covering the brain and spinal cord caused by adenoviral. QY, JX, HY http://en.volupedia.org/wiki/Meningitis 腺病毒性脑膜炎 10080442 adenoviral meningitis AE This is an AE which is rare but well recognised entity usually manifesting 1-4 weeks after anoxic exposure and characteristic subcortical white matter demyelination with necrosis of globus pallidus. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/7644404/ 缺氧脑病 10050750 anoxic encephalopathy AE This is an AE which is a structural defect in the cerebellum, characterized by a downward displacement of one or both cerebellar tonsils through the foramen magnum (the opening at the base of the skull). QY, JX, HY http://en.volupedia.org/wiki/Chiari_malformation 阿－基氏脑畸形 1003101 arnold-chiari malformation AE This is an AE which is a motor disorder caused by damage to the brain (specifically the posterior parietal cortex or corpus callosum) which causes difficulty with motor planning to perform tasks or movements. QY, JX, HY http://en.volupedia.org/wiki/Apraxia 失用症 10003062 apraxia AE This is an AE which represents a complex category of disease with diverse immunologic associations, clinical manifestations, and therapeutic outcomes. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21590620/ 自身免疫性脑病 10075691 autoimmune encephalopathy AE This is an AE which is a rare inflammatory disorder of the central nervous system,It may also affect the peripheral nervous system, and has features in common with both Miller Fisher syndrome and Guillain Barré syndrome. QY, JX, HY http://en.volupedia.org/wiki/Bickerstaff_brainstem_encephalitis 比克斯塔夫脑炎 10076985 bickerstaff's encephalitis AE This is an AE which is a rare and fatal autosomal recessive degenerative disorder that causes progressive damage to nerve cells and loss of white matter in the brain. QY, JX, HY http://en.volupedia.org/wiki/Canavan_disease 海绵状脑白质营养不良症 10067608 canavan disease AE This is an AE which is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. QY, JX, HY http://en.volupedia.org/wiki/Lymphocytic_choriomeningitis 淋巴细胞性脉络丛脑膜炎 10008761 chorio meningitis lymphocytic AE This is an AE which is an extremely rare cephalic disorder involving encephalomalacia. QY, JX, HY http://en.volupedia.org/wiki/Porencephaly 脑穿通畸形 10036172 porencephaly AE This is an AE which is a rare condition in which parts of the brain are affected by swelling, usually as a result of an underlying cause. QY, JX, HY http://en.volupedia.org/wiki/Posterior_reversible_encephalopathy_syndrome 后部可逆性脑病综合征 10071066 posterior reversible encephalopathy syndrome AE This is an AE which is commonly associated with significant morbidity. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/?term=postresuscitation+encephalopathy 复苏后脑病 10068191 postresuscitation encephalopathy AE This is an AE which is a rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). QY, JX, HY http://en.volupedia.org/wiki/Progressive_multifocal_leukoencephalopathy 进行性多灶性白质脑病 10036807 progressive multifocal leukoencephalopathy AE This is an AE which is a rare inflammatory neurological disease, characterized by frequent and severe seizures, loss of motor skills and speech, hemiparesis (weakness on one side of the body), encephalitis (inflammation of the brain), and dementia. QY, JX, HY http://en.volupedia.org/wiki/Rasmussen%27s_encephalitis 拉斯姆森脑炎 10071141 rasmussen encephalitis AE This is an AE which is a common complication in septic patients and clinical presentation may range from mild confusion and disorientation to convulsions and deep coma. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30280261/ 败血性脑病 10069141 septic encephalopathy AE This is an AE which is a rare benign disease that can cause myelopathy. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/26585731/ 脊髓脑膜囊肿 10067375 spinal meningeal cyst AE This is an AE which is either caused by trauma including that arising from medical interventions or spontaneously sometimes in those with predisposing conditions. QY, JX, HY http://en.volupedia.org/wiki/Cerebrospinal_fluid_leak 自发性脑脊液漏综合征 10073081 spontaneous cerebrospinal fluid leak syndrome AE This is an AE which is a rare form of chronic, progressive brain inflammation caused by slow infection with certain defective strains of hypermutated measles virus. QY, JX, HY http://en.volupedia.org/wiki/Subacute_sclerosing_panencephalitis 亚急性硬化性全脑炎 10042297 subacute sclerosing panencephalitis AE This is an AE which can present with a variety of sensory deficits that can be difficult to diagnose clinically because of their seemingly disconnected manifestations. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/23269103/ 丘脑梗塞 10064961 thalamic infarction AE This is an AE which is an injury to the brain caused by an external force. QY, JX, HY http://en.volupedia.org/wiki/Traumatic_brain_injury 创伤性脑损伤 10060690 traumatic brain injury AE This is an AE which is a disease linked to the X chromosome and is a result of fatty acid buildup caused by a defect in the very long chain of fatty acids transporter in peroxisomes, which then causes damage to the myelin sheath of the nerves, resulting in seizures and hyperactivity. QY, JX, HY http://en.volupedia.org/wiki/Adrenoleukodystrophy 肾上腺脑白质营养不良 10051260 adrenoleukodystrophy AE This is an AE which means any disorder or disease of the brain caused by AIDs, especially chronic degenerative conditions. QY, JX, HY http://en.volupedia.org/wiki/Encephalopathy 艾滋病脑病 10049072 aids encephalopathy AE This is an AE which is a communication disorder resulting in incoherent talkativeness. QY, JX, HY http://en.volupedia.org/wiki/Logorrhea 多语症，速语症 10024796 logorrhoea AE This is an AE which is a closed sac on the pituitary, having a distinct envelope and division compared with the nearby tissue. QY, JX, HY http://en.volupedia.org/wiki/Cyst 垂体囊肿 10051687 pituitary cyst AE This is an AE which is the increase in the volume of pituitary tissue due to the enlargement of its component cells. QY, JX, HY http://en.volupedia.org/wiki/Hypertrophy 垂体增大 10048675 pituitary enlargement AE This is an AE which is tumors that occur in the pituitary gland. QY, JX, HY http://en.volupedia.org/wiki/Pituitary_adenoma 垂体肿瘤 10035104 pituitary tumor AE This is an AE which is a pituitary mass of cells (tumor) that lacks the ability to either invade neighboring tissue or metastasize (spread throughout the body). QY, JX, HY http://en.volupedia.org/wiki/Benign_tumor 良性垂体肿瘤 10061538 pituitary tumor benign AE This is an AE which is characterized by the absence of a subjacent cerebral lesion and neurological or intellectual deficit. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/11785036/ 特发性局灶性癫痫 10076552 idiopathic partial epilepsy AE This is an AE which is seizures which affect initially only one hemisphere of the brain. QY, JX, HY http://en.volupedia.org/wiki/Focal_seizure 部分癫痫发作 10061334 partial seizures AE This is an AE which is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. QY, JX, HY http://en.volupedia.org/wiki/Epilepsy 癫痫 10015037 epilepsy AE This is an AE which is a single seizure lasting more than 5 minutes or two or more seizures within a five-minute period without the person returning to normal between them. QY, JX, HY http://en.volupedia.org/wiki/Status_epilepticus 癫痫持续状态 10041962 status epilepticus AE This is an AE which is common, particularly in the setting of medically refractory epilepsy. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25695133/ 癫痫发作群 10071350 seizure cluster AE This is an AE which is primarily a disorder of childhood. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/414604/ 癫痫小发作癫痫 10034759 petit mal epilepsy AE This is an AE which is a neurological disorder that is characterized by brief, recurring seizures that arise in the frontal lobes of the brain, often while the patient is sleeping. QY, JX, HY http://en.volupedia.org/wiki/Frontal_lobe_epilepsy 额叶癫痫 10049424 frontal lobe epilepsy AE This is an AE which should be recognized as a discrete epileptic syndrome. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21093732/ 非典型良性部分癫痫 10056699 atypical benign partial epilepsy AE This is an AE which is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain caused by hyperglycaemic . QY, JX, HY http://en.volupedia.org/wiki/Seizure 高血糖癫痫发作 10071394 hyperglycaemic seizure AE This is an AE which is divided into simple and dyscognitive, with the latter resulting in the alteration of consciousness. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28362654/ 局灶性认知障碍癫痫发作 10079424 focal dyscognitive seizures AE This is an AE which is the most common epilepsy syndrome in childhood. QY, JX, HY http://en.volupedia.org/wiki/Rolandic_epilepsy 良性中央癫痫 10070530 benign rolandic epilepsy AE This is an AE which is subdivided into syndromes based on clinical and EEG features. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/17223580/ 特发性全身性癫痫 10071081 idiopathic generalised epilepsy AE This is an AE which is a type of seizure that consists of partial or complete loss of muscle tone that is caused by temporary alterations in brain function. QY, JX, HY http://en.volupedia.org/wiki/Atonic_seizure 无源性癫痫发作 10003628 atonic seizures AE This is an AE which is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain and is psychogenic . QY, JX, HY http://en.volupedia.org/wiki/Seizure 心因性癫痫发作 10058895 psychogenic seizure AE This is an AE which is condition that affects one side of the body. QY, JX, HY http://en.volupedia.org/wiki/Hemiplegic_migraine 偏瘫型偏头痛 10019476 hemiplegic migraine AE This is an AE which is a complication of migraine (with or without aura), representing an attack that lasts for more than 72 h. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30198804/ 偏头痛状态 10052945 status migrainosus AE This is an AE which is a neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye. QY, JX, HY http://en.volupedia.org/wiki/Cluster_headache 丛集性头痛 10059133 cluster headache AE This is an AE which is the decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain. QY, JX, HY http://en.volupedia.org/wiki/Hypopituitarism 垂体机能减退 10021067 hypopituitarism AE This is an AE which is a particular abnormal change in appearance of white matter near the lateral ventricles. QY, JX, HY http://en.volupedia.org/wiki/Leukoaraiosis 白质病变 10072731 white matter lesion AE This is an AE which is basal ganglia tissue death (necrosis) due to inadequate blood supply to the affected area. QY, JX, HY http://en.volupedia.org/wiki/Infarction 基底节梗塞 10069020 basal ganglia infarction AE This is an AE which is a primary headache disorder characterized by recurrent headaches that are moderate to severe. QY, JX, HY http://en.volupedia.org/wiki/Migraine 基底性偏头痛 10050258 basilar migraine AE This is an AE which is an anatomical feature of the infant human skull comprising soft membranous gaps (sutures) between the cranial bones that make up the calvaria of a fetus or an infant and it is depressed. QY, JX, HY http://en.volupedia.org/wiki/Fontanelle 囟门凹陷 10053214 fontanelle depressed AE This is an AE which case as a patient with a bulging fontanelle, normal neuroimaging and cerebrospinal fluid analysis, and absence of a depressed level of consciousness, focal neurologic findings, or identified cause. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/16291356/ 囟门膨大 10016945 fontanelle bulging AE This is an AE which includes achondroplasia, hypothyroidism, Down syndrome, increased intracranial pressure, and rickets. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/12825844/ 囟门延迟关闭 10054034 delayed fontanelle closure AE This is an AE which has itself since been replaced by other terms QY, JX, HY http://en.volupedia.org/wiki/Intellectual_disability#Terminology 严重智力低下 10036791 profound mental retardation AE This is an AE which is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomata. QY, JX, HY http://en.volupedia.org/wiki/Sarcoidosis 结节病 10039486 sarcoidosis AE This is an AE which is any of three medical signs, all of which may occur in meningitis or meningism. QY, JX, HY http://en.volupedia.org/wiki/Brudzi%C5%84ski%27s_sign 布鲁金斯基征 10064010 brudzinski's sign AE This is an AE which is the yellowish appearance of cerebrospinal fluid that occurs several hours after bleeding into the subarachnoid space caused by certain medical conditions, most commonly subarachnoid hemorrhage. QY, JX, HY http://en.volupedia.org/wiki/Xanthochromia 黄变症 10048213 xanthochromia AE This is an AE which is a fatal degenerative brain disorder. QY, JX, HY http://en.volupedia.org/wiki/Creutzfeldt%E2%80%93Jakob_disease 克雅二氏症 10011384 creutzfeldt-jakob disease AE This is an AE which is a potentially fatal disturbance in brain functions that results when the normal balance of electrolytes in the body is pushed outside safe limits by excessive water intake. QY, JX, HY http://en.volupedia.org/wiki/Water_intoxication 水中毒 10047837 water intoxication AE QY, JX, HY 脑硬化 10059150 cerebrosclerosis AE QY, JX, HY 下丘脑-垂体疾病 10021111 hypothalamo-pituitary disorder AE QY, JX, HY 非感染性脑炎 10074712 noninfective encephalitis AE QY, JX, HY 脑炎后免疫 10014602 encephalitis post immunisation AE QY, JX, HY 脑炎后麻疹 10014604 encephalitis post measles AE QY, JX, HY 脑炎后水痘 10014603 encephalitis post varicella AE QY, JX, HY 癫痫样现象 10071048 seizure like phenomena AE QY, JX, HY 偏瘫 10078746 hemiparaesthesia AE QY, JX, HY 偏头痛 10067040 hemicephalalgia AE This is an AE which is an unfavorable result of a disease, health condition, or treatment and its maybe lead atrial fibrillation. QY, JX, HY http://en.volupedia.org/wiki/Complication_(medicine)#Cardiovascular_complications 心脏手术并发症 10057461 cardiac procedure complication AE This is an AE which is any cardiovascular disease process involving one or more of the four valves of the heart (the aortic and mitral valves on the left side of heart and the pulmonic and tricuspid valves on the right side of heart). QY, JX, HY http://en.volupedia.org/wiki/Valvular_heart_disease 心脏瓣膜赘生物 10057651 cardiac valve vegetation AE This is an AE which are systemic diseases frequently affecting the heart and vessels. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32883041/ 风湿性心包炎 10034496 pericarditis rheumatic AE This is an AE which can be measured locoregionally to produce a map of systolic activity that reproduces the complex way in which the ventricle contracts. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/31005299/ 心肌劳损 10066954 myocardial strain AE This is an AE which during thoracic surgery can have profound hemodynamic consequences and lead to devastating neurologic injury. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/27871599/ 上腔静脉阻塞 10058988 superior vena caval occlusion AE This is an AE which is a devastating neurological disease for which there is no effective therapy. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/1434509/ 高血糖症 10080883 hyperglycinaemia AE This is an AE which is a fluid-filled space surrounding certain blood vessels in several organs, including the brain,potentially having an immunological function, but more broadly a dispersive role for neural and blood-derived messengers. QY, JX, HY http://en.volupedia.org/wiki/Perivascular_space 大脑血管周围间隙扩大 10068734 enlarged cerebral perivascular spaces AE This is an AE which is a group of disorders that destroy blood vessels by inflammation and it is diffuse. QY, JX, HY http://en.volupedia.org/wiki/Vasculitis 弥散性血管炎 10012978 diffuse vasculitis AE This is an AE which is a group of disorders with with necrotising that destroy blood vessels by inflammation . QY, JX, HY http://en.volupedia.org/wiki/Vasculitis 血管炎坏死 10047124 vasculitis necrotising AE This is an AE which is a mechanical occlusion of the extracranial vertebral artery(VA)due to physiological movement of the head and neck. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/33353881/ 椎动脉闭塞 10048965 vertebral artery occlusion AE This is an AE which is a medical condition in which injury to the large or small intestine occurs due to not enough blood supply. QY, JX, HY http://en.volupedia.org/wiki/Intestinal_ischemia 血管功能不全 10054880 vascular insufficiency AE This is an AE which is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system and heart is feel discomfortable. QY, JX, HY http://en.volupedia.org/wiki/Heart 心脏不舒服 10054211 cardiac discomfort AE This is an AE which is a pathological wound healing in which connective tissue replaces normal arterial parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue. QY, JX, HY http://en.volupedia.org/wiki/Fibrosis 动脉纤维化 10054793 arterial fibrosis AE This is an AE which is a rare complication in angiosarcoma. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/23542097/ 心房破裂 10048761 atrial rupture AE This is an AE which is a syndrome defined as the new onset (de novo heart failure (HF)) or worsening (acutely decompensated heart failure (ADHF)) of symptoms and signs of HF, mostly related to systemic congestion. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32139695/ 急性左心室衰竭 10063081 acute left ventricular failure AE This is an AE which is a type of respiratory failure characterized. QY, JX, HY http://en.volupedia.org/wiki/Acute_respiratory_distress_syndrome 呼吸窘迫 10049874 cardio-respiratory distress AE This is an AE which is a usually benign vascular tumor derived from blood liver vessel cell types. QY, JX, HY http://en.volupedia.org/wiki/Hemangioma 肝血管瘤 10018821 haemangioma of liver AE This is an AE which is a usually benign vascular tumor derived from bone blood vessel cell types. QY, JX, HY http://en.volupedia.org/wiki/Hemangioma 骨血管瘤 10072572 haemangioma of bone AE This is an AE which is an abnormal connection or passageway between an artery and a vein and the connection or passageway may be occlusion. QY, JX, HY http://en.volupedia.org/wiki/Arteriovenous_fistula 动静脉瘘闭塞 10058562 arteriovenous fistula occlusion AE This is an AE which is an abnormal connection or passageway between an artery and a vein. QY, JX, HY http://en.volupedia.org/wiki/Arteriovenous_fistula 动静脉瘘动脉瘤 10066916 arteriovenous fistula aneurysm AE This is an AE which is an abnormally dilated vessel occured on splenic with a tortuous course and haemorrhagic. QY, JX, HY http://en.volupedia.org/wiki/Varices 脾静脉曲张出血 10068662 splenic varices hemorrhage AE This is an AE which is blood escaping from the circulatory system from damaged blood vessels on pregnancy. QY, JX, HY http://en.volupedia.org/wiki/Bleeding 妊娠出血 10018981 hemorrhage in pregnancy AE This is an AE which is blood escaping from the circulatory system from damaged blood vessels occured on subcutaneous. QY, JX, HY http://en.volupedia.org/wiki/Bleeding 皮下出血 10018999 hemorrhage subcutaneous AE This is an AE which is blood escaping from the circulatory system from damaged blood vessels occured on subepidermal. QY, JX, HY http://en.volupedia.org/wiki/Bleeding 表皮下出血 10019001 hemorrhage subepidermal AE This is an AE which is characterized by various clinical manifestations and immunologic abnormalities. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28675998/ 心包炎红斑狼疮 10058149 pericarditis lupus AE This is an AE which is inflammation of the pleuro pericardium (the fibrous sac surrounding the heart). QY, JX, HY http://en.volupedia.org/wiki/Pericarditis 胸膜心包炎 10059361 pleuro pericarditis AE This is an AE which is the formation of a pulmonary artery blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. QY, JX, HY http://en.volupedia.org/wiki/Thrombosis 肺动脉血栓形成 10037340 pulmonary artery thrombosis AE This is an AE which is usually refers drug withdrawal such as clonidine. QY, JX, HY http://en.volupedia.org/wiki/Clonidine#Drug_withdrawal 戒断性高血压 10048007 withdrawal hypertension AE This is an AE which is very high blood pressure with potentially life-threatening symptoms and signs of acute damage to one or more organ systems especially kidneys. QY, JX, HY http://en.volupedia.org/wiki/Hypertensive_emergency 恶性高血压肾 10026674 malignant renal hypertension AE This is an AE which it is a condition characterized by abnormally low levels of platelets with haemangioma. QY, JX, HY http://en.volupedia.org/wiki/Thrombocytopenia 血管瘤-血小板减少综合征 10058423 haemangioma-thrombocytopenia syndrome AE This is an AE which refers to a blood pressure measurements and is out of the range of 60-80mmHg at adults. QY, JX, HY http://en.volupedia.org/wiki/Hypertension 舒张期高血压 10012758 diastolic hypertension AE This is an AE which is a class of diseases that involve the heart or blood vessels. QY, JX, HY http://en.volupedia.org/wiki/Cardiovascular_disease 心血管疾病 10007649 cardiovascular disorder AE This is an AE which is characterized by excessive thoughts, feelings, and behaviors associated with physical symptoms with cardiovascular. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30578985/ 心血管症状障碍 10078078 cardiovascular somatic symptom disorder AE This is an AE which is a perceptual disturbance experienced by some with epilepsy or migraine with cardiovascular. QY, JX, HY http://en.volupedia.org/wiki/Aura_(symptom) 心血管征兆 10075534 cardiovascular symptom AE This is an AE which is a medical procedure by which an abnormally fast heart rate (tachycardia) or other cardiac arrhythmia is converted to a normal rhythm using electricity or drugs. QY, JX, HY http://en.volupedia.org/wiki/Cardioversion 心脏复律 10007661 cardioversion AE This is an AE which is the inflammation of the heart. QY, JX, HY http://en.volupedia.org/wiki/Carditis 心脏炎，心肌炎 10062746 carditis AE This is an AE which is a sudden loss of blood flow resulting from the failure of the heart to pump effectively occured on neonatal. QY, JX, HY http://en.volupedia.org/wiki/Cardiac_arrest 新生儿心脏骤停 10007516 cardiac arrest neonatal AE This is an AE which is a medical diagnosis of wheezing, coughing, dyspnea, bloody sputum, or shortness of breath due to congestive heart failure. QY, JX, HY http://en.volupedia.org/wiki/Cardiac_asthma 心病性哮喘 10007522 cardiac asthma AE This is an AE which is an injury to the heart as the result of blunt trauma, typically to the anterior chest wall. QY, JX, HY http://en.volupedia.org/wiki/Blunt_cardiac_injury 心源性挫伤 10073356 cardiac contusion AE This is an AE which is a set of manifestations caused by the failure of the heart's function as a pump supporting the blood flow through the body; its signs and symptoms result from a structural and/or functional abnormality of the heart, that disrupts its filling with blood or its ejecting of it during each heart beat QY, JX, HY http://en.volupedia.org/wiki/Heart_failure 心脏功能障碍 10079751 cardiac dysfunction AE This is an AE which is a syndrome defined as the new onset (de novo heart failure (HF)) or worsening (acutely decompensated heart failure (ADHF)) of symptoms and signs of HF, mostly related to systemic congestion. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32139695/ 急性心力衰竭 10007556 cardiac failure acute AE This is an AE which is a long-term condition, usually kept stable by the treatment of symptoms. QY, JX, HY http://en.volupedia.org/wiki/Heart_failure#Classification_2 慢性心脏衰竭 10007558 cardiac failure chronic AE This is an AE which is an irregular and uncoordinated contraction of the cardiac muscle of atria. QY, JX, HY http://en.volupedia.org/wiki/Fibrillation 心脏颤动 10061592 cardiac fibrillation AE This is an AE which a common abnormal heart rhythm. QY, JX, HY http://en.volupedia.org/wiki/Flutter 心脏扑动 10052840 cardiac flutter AE This is an Ae which is thickening of the walls of a ventricle (lower chamber) of the heart. QY, JX, HY http://en.volupedia.org/wiki/Ventricular_hypertrophy 心脏肥大 10007572 cardiac hypertrophy AE This is an AE which refers to an abnormal intrathoracic position of the heart. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21861958/ 心脏错位 10007585 cardiac malposition AE This is an AE which is a heart murmur that is primarily due to physiologic conditions outside the heart, as opposed to structural defects in the heart itself. QY, JX, HY http://en.volupedia.org/wiki/Functional_murmur 心脏有杂音 10007587 cardiac murmur functional AE This is an AE which is a term used in cardiac physiology that describes the volume of blood being pumped by the heart, by the left and right ventricle, per unit time. QY, JX, HY http://en.volupedia.org/wiki/Cardiac_output 心输出量 10007594 cardiac output AE This is an AE which is a defect in the structure of the heart or great vessels. QY, JX, HY http://en.volupedia.org/wiki/Congenital_heart_defect 心脏间隔缺损 10064021 cardiac septal defect AE This is an AE which is a condition in which the heart becomes thickened without an obvious cause. QY, JX, HY http://en.volupedia.org/wiki/Hypertrophic_cardiomyopathy 心脏中隔肥大 10057576 cardiac septal hypertrophy AE This is an AE which is the narrowing of the exit of the left ventricle of the heart (where the aorta begins), such that problems result. QY, JX, HY http://en.volupedia.org/wiki/Aortic_stenosis 心脏瓣膜硬化症 10061082 cardiac valve sclerosis AE This is an AE which is a medical emergency resulting from inadequate blood flow due to the dysfunction of the ventricles of the heart. QY, JX, HY http://en.volupedia.org/wiki/Cardiogenic_shock 心原性休克 10007625 cardiogenic shock AE This is an AE which refers to a cluster of related risk factors for cardiovascular disease that includes abdominal obesity, diabetes, hypertension, and elevated cholesterol. QY, JX, HY http://en.volupedia.org/wiki/Epidemiology_of_metabolic_syndrome 心血管代谢疾病综合症 10082306 cardio metabolic syndrome AE This is an AE which is a technique in which a machine temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the patient's body. QY, JX, HY http://en.volupedia.org/wiki/Cardiopulmonary_bypass 心肺分流术 10066123 cardio pulmonary bypass AE This is an AE which is a sudden loss of blood flow resulting from the failure of the heart to pump effectively. QY, JX, HY http://en.volupedia.org/wiki/Cardiac_arrest 心肺骤停 10007617 cardio-respiratory arrest AE This is an AE which is a sudden loss of blood flow resulting from the failure of the heart to pump effectively at neonatal. QY, JX, HY http://en.volupedia.org/wiki/Cardiac_arrest 新生儿心肺骤停 10007618 cardio-respiratory arrest neonatal AE This is an AE which is a failure of smooth muscle fibers to relax, which can cause the lower esophageal sphincter to remain closed. QY, JX, HY http://en.volupedia.org/wiki/Esophageal_achalasia 贲门痉挛 10007645 cardiospasm AE This is an AE which has been a useful index of cardiac dilatation, and a value of 50% is generally considered to indicate the upper limit of normal cardiac size. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/7666345/ 心胸比率 10068336 cardiothoracic ratio AE This is an AE which is a congenital malformation in which the heart is abnormally located either partially or totally outside of the thorax. QY, JX, HY http://en.volupedia.org/wiki/Ectopia_cordis 心脏异位 10014144 ectopia cordis AE This is an AE which is some of the commonest congenital disorders seen in prenatal life and they can be anatomical or functional and can develop de novo or as a consequence of either maternal or fetal disease. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/29716424/ 胎儿心脏疾病 10052088 foetal cardiac disorder AE This is an AE which occurs when transplanted heart is rejected by the recipient's immune system, which destroys the transplanted heart . QY, JX, HY http://en.volupedia.org/wiki/Transplant_rejection 心脏移植排斥反应 10019315 heart transplant rejection AE This is an AE which is a one-way valve that normally allows blood to flow in only one direction through the heart and its functions are incompleted. QY, JX, HY http://en.volupedia.org/wiki/Heart_valve 心脏瓣膜功能不全 10067660 heart valve incompetence AE This is an AE which is a type of complications of high blood pressure that affect the heart. QY, JX, HY http://en.volupedia.org/wiki/Hypertensive_heart_disease 高血压心脏肥大 10020801 hypertensive cardiomegaly AE This is an AE which includes a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation caused by hypertensive. QY, JX, HY http://en.volupedia.org/wiki/Cerebrovascular_disease 高血压脑血管疾病 10077000 hypertensive cerebrovascular disease AE This is an AE which is very high blood pressure with potentially life-threatening symptoms and signs of acute damage to one or more organ systems (especially brain, eyes, heart, aorta, or kidneys). QY, JX, HY http://en.volupedia.org/wiki/Hypertensive_emergency 高血压急症 10058179 hypertensive emergency AE This is an AE which is general brain dysfunction due to significantly high blood pressure. QY, JX, HY http://en.volupedia.org/wiki/Hypertensive_encephalopathy 高血压脑病 10020803 hypertensive encephalopathy AE This is an AE which includes a number of complications of high blood pressure that affect the heart. QY, JX, HY http://en.volupedia.org/wiki/Hypertensive_heart_disease 高血压心脏病 10020823 hypertensive heart disease AE This is an AE which is a clinical situation in which blood pressure is very high (e.g., 220/125 mmHg) with minimal or no symptoms, and no signs or symptoms indicating acute organ damage. QY, JX, HY http://en.volupedia.org/wiki/Hypertensive_urgency 高血压急症 10058181 hypertensive urgency AE This is an AE which refers to valvular heart disease resulting from rheumatic fever. QY, JX, HY http://en.volupedia.org/wiki/Valvular_heart_disease#Inflammatory_disorders 风湿性心脏病 10062110 rheumatic heart disease AE This is an AE which moved from hearts with only one ventricle connected with atria [double inlet ventricle or absent atrioventricular (AV) connection] to hearts not amenable to biventricular repair, namely hearts with two ventricles unable to sustain separately pulmonary and systemic circulations in sequence. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25072035/ 单心室心脏 10045545 univentricular heart AE This is an AE which is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease when other medical or surgical treatments have failed and the surgical appear complications. QY, JX, HY http://en.volupedia.org/wiki/Heart_transplantation 移植心脏并发症 10010184 complications of transplanted heart AE This is an AE which is when bleeding occurs between the tough outer membrane covering the brain (dura mater) and the skull. QY, JX, HY http://en.volupedia.org/wiki/Epidural_hematoma 硬膜外血肿 10015769 extradural hematoma AE This is an AE which is an abnormal connection between arteries and veins, bypassing the capillary system with haemorrhagic. QY, JX, HY http://en.volupedia.org/wiki/Arteriovenous_malformation 出血热动静脉畸形 10064595 haemorrhagic arteriovenous malformation AE This is an AE which is bleeding within the skull. QY, JX, HY http://en.volupedia.org/wiki/Intracranial_hemorrhage 颅内出血 10018985 hemorrhage intracranial AE This is an AE which is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood or a lowered ability of the blood to carry oxygen caused by haemorrhagic. QY, JX, HY http://en.volupedia.org/wiki/Anemia 出血性贫血 10052293 haemorrhagic anemia AE This is an AE which is the pathologic process that results in an area of necrotic tissue in the brain (cerebral infarct) with haemorrhagic. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_infarction 出血性脑梗死 10019005 haemorrhagic cerebral infarction AE This is an AE which having a distinct envelope and division compared with the nearby tissue and haemorrhagic . QY, JX, HY http://en.volupedia.org/wiki/Cyst 出血性囊肿 10059189 haemorrhagic cyst AE This is an AE which is a rare form of bleeding disorder that affects newborns and young infants due to low stores of vitamin K at birth. QY, JX, HY http://en.volupedia.org/wiki/Vitamin_K_deficiency_bleeding 新生儿出血症 10019008 haemorrhagic disease of newborn AE This is an AE which is the consequences of haemostasis dysfunction or defects. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/26165091/ 出血性疾病 10019009 haemorrhagic disorder AE This is an AE which is tissue death (necrosis) due to inadequate blood with haemorrhagic supply to the affected area . QY, JX, HY http://en.volupedia.org/wiki/Infarction 出血性梗死 10019013 haemorrhagic infarction AE This is an AE which appears as a complex cystic mass arising from an ovary, with a reticular pattern of internal echoes representing internal fibrin strands. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30309168/ 出血性卵巢囊肿 10060781 haemorrhagic ovarian cyst AE This is an AE which is an inflammatory condition of the lung primarily affecting the small air sacs known as alveoli with haemorrhagic . QY, JX, HY http://en.volupedia.org/wiki/Pneumonia 出血性肺炎 10077933 haemorrhagic pneumonia AE This is an AE which is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. QY, JX, HY http://en.volupedia.org/wiki/Intracerebral_hemorrhage 出血性中风 10019016 haemorrhagic stroke AE This is an AE which is part of the natural history of some forms of ischaemic infarction, especially cerebral embolism, but it can be precipitated or enhanced by therapeutic interventions used in the acute phase of ischaemic stroke. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/23726850/ 出血性转换中风 10055677 haemorrhagic transformation stroke AE This is an AE which is a kind of skin rash with red, raised, itchy bumps with haemorrhagic. QY, JX, HY http://en.volupedia.org/wiki/Hives 出血性热荨麻疹 10059499 haemorrhagic urticaria AE This is an AE which is a group of disorders that destroy blood vessels by inflammation with haemorrhagic . QY, JX, HY http://en.volupedia.org/wiki/Vasculitis 出血性血管炎 10071252 haemorrhagic vasculitis AE This is an AE which is cushions of submucosal vascular tissue located in the anal canal starting just distal to the dentate line and the anal canal is with haemorrhage. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/19445775/ 直肠出血 10054787 haemorrhoidal hemorrhage AE This is an AE which is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. QY, JX, HY http://en.volupedia.org/wiki/Haemophilia 血友病 10061992 haemophilia AE This is an AE which is a condition of unrecognized origin which can become extremely serious and whose diagnosis is often made during perinatal autopsy and is often characterised by nonspecific clinical manifestations and a long delay before biological presentation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28748016/ 肝出血 10019677 hepatic hemorrhage AE This is an AE which is a condition that occurs when blood enters the front (anterior) chamber of the eye between the iris and the cornea. QY, JX, HY http://en.volupedia.org/wiki/Hyphema 眼前房出血 10020923 hyphaema AE This is an AE which is a loss of blood from a blood vessel that collects inside the body. QY, JX, HY http://en.volupedia.org/wiki/Internal_bleeding 内部出血 10075192 internal hemorrhage AE This is an AE which is a bleeding into the brain's ventricular system, where the cerebrospinal fluid is produced and circulates through towards the subarachnoid space. QY, JX, HY http://en.volupedia.org/wiki/Intraventricular_hemorrhage 脑室出血 10022840 intraventricular hemorrhage AE This is an AE which is a devastating cause of stroke and is a devastating injury for which prompt, effective treatment can impact meaningful survival. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25498578/ 颅内血肿 10059491 intracranial hematoma AE This is an AE which is a bleeding into the brain's ventricular system, where the cerebrospinal fluid is produced and circulates through towards the subarachnoid space occurs on neonatal. QY, JX, HY http://en.volupedia.org/wiki/Intraventricular_hemorrhage 新生儿脑室出血 10022841 intraventricular hemorrhage neonatal AE This is an AE which refers to a part of the eye with haemorrhage. QY, JX, HY http://en.volupedia.org/wiki/Iris 虹膜出血 10057418 iris hemorrhage AE This is an AE which is a membrane that lines various cavities in the body and covers the surface of internal organs and the membrane is haemorrhage. QY, JX, HY http://en.volupedia.org/wiki/Mucous_membrane 粘膜出血 10061298 mucosal hemorrhage AE This is an AE which is a membrane that lines various cavities in the body and covers the surface of internal organs and the membrane is hyperaemia. QY, JX, HY http://en.volupedia.org/wiki/Mucous_membrane 粘膜充血 10065334 mucosal hyperemia AE This is an AE which can cause complications such as nerve injury, compartment syndrome, myositis ossificans, pseudotumour, and even infection (abscess). QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/24914744/ 肌肉出血 10028309 muscle hemorrhage AE This is an AE which is an organ in vertebrates through which food passes, aided by peristaltic contractions, from the pharynx to the stomach and the organ is haemorrhage. QY, JX, HY http://en.volupedia.org/wiki/Esophagus 食管大出血 10030172 esophageal hemorrhage AE This is an AE which is a sudden inflammation of the pancreas with hemorrhagic. QY, JX, HY http://en.volupedia.org/wiki/Acute_pancreatitis 胰腺炎出血 10033650 pancreatitis haemorrhagic AE This is an AE which is an abnormal accumulation of fluid in the pericardial cavity with haemorrhage. QY, JX, HY http://en.volupedia.org/wiki/Pericardial_effusion 心包出血 10034476 pericardial hemorrhage AE This is an AE which is often associated with high morbidity and mortality and serves as an important clinical predictor of poor outcomes after intracranial haemorrhage (ICH). QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28716276/ 出血后脑积水 10079859 posthaemorrhagic hydrocephalus AE This is an AE which is an inflammation of the anus and the lining of the rectum with haemorrhagic, affecting only the last 6 inches of the rectum. QY, JX, HY http://en.volupedia.org/wiki/Proctitis 出血性直肠炎 10036778 proctitis haemorrhagic AE This is an AE which is all the tissue in the body that is not hardened by the processes of ossification or calcification with haemorrhage. QY, JX, HY http://en.volupedia.org/wiki/Soft_tissue 软组织出血 10051297 soft tissue hemorrhage AE This is an AE which is blood escaping from the circulatory system from damaged blood vessels occured on splenic. QY, JX, HY http://en.volupedia.org/wiki/Bleeding 脾出血 10041647 splenic hemorrhage AE This is an AE which is a recognized characteristic physical sign of endocarditis and other systemic conditions associated with splinter haemorrhages include systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, peptic ulcer disease, malignancies, use of the oral contraceptive pill, pregnancy and psoriasis . QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/24273777/ 碎片出血 10041663 splinter hemorrhages AE This is an AE which is bleeding into the subarachnoid space the neonatal area between the arachnoid membrane and the pia mater surrounding the brain. QY, JX, HY http://en.volupedia.org/wiki/Subarachnoid_hemorrhage 新生儿蛛网膜下腔出血 10042317 subarachnoid hemorrhage neonatal AE This is an AE which is bleeding beneath the chorion membranes that enclose the embryo in the uterus and appears to occur due to partial detachment of the chorion membranes from the wall of the uterus. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32644443/ 绒毛膜下血肿 10072596 subchorionic hematoma AE This is an AE which is bleeding beneath the chorion membranes that enclose the embryo in the uterus and appears to occur due to partial detachment of the chorion membranes from the wall of the uterus. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32644443/ 绒毛膜下出血 10071010 subchorionic hemorrhage AE This is an AE which is a type of bleeding in which a collection of blood—usually associated with a traumatic brain injury—gathers between the inner layer of the dura mater and the arachnoid mater of the meninges surrounding the brain. QY, JX, HY http://en.volupedia.org/wiki/Subdural_hematoma 硬膜下出血 10042364 subdural hemorrhage AE This is an AE which is usually considered a single entity although the thalamus is composed of anatomically as well as functionally discrete subregions receiving blood from different arteries. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/9009994/ 丘脑出血 10058939 thalamus hemorrhage AE This is an AE which is a condition characterized by increased intracranial pressure (pressure around the brain) without a detectable cause. QY, JX, HY http://en.volupedia.org/wiki/Idiopathic_intracranial_hypertension 良性颅内高血压 10004277 benign intracranial hypertension AE This is an AE which is the pressure of circulating blood against the walls of blood vessels and the data is fluctuation. QY, JX, HY http://en.volupedia.org/wiki/Blood_pressure 血压波动 10005746 blood pressure fluctuation AE This is an AE which is the form of hypertension that by definition has no identifiable secondary cause. QY, JX, HY http://en.volupedia.org/wiki/Essential_hypertension 原发性高血压 10015488 essential hypertension AE This is an AE which is the development of new hypertension in a pregnant woman after 20 weeks' gestation without the presence of protein in the urine or other signs of pre-eclampsia. QY, JX, HY http://en.volupedia.org/wiki/Gestational_hypertension 妊娠期高血压 10070538 gestational hypertension AE This is an AE which is a condition characterized by increased intracranial pressure (pressure around the brain) without a detectable cause. QY, JX, HY http://en.volupedia.org/wiki/Idiopathic_intracranial_hypertension 特发性颅内高血压 10078904 idiopathic intracranial hypertension AE This is an AE which is very high blood pressure with potentially life-threatening symptoms and signs of acute damage to one or more organ systems (especially brain, eyes, heart, aorta, or kidneys). QY, JX, HY http://en.volupedia.org/wiki/Hypertensive_emergency 恶性高血压 10025600 malignant hypertension AE This is an AE which is defined as systolic and/or diastolic BPs persistently equal to or greater than the 95th percentile for age, gender, and height. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/29808264/ 新生儿低血压 10049223 neonatal hypotension AE This is an AE which is a medical condition consisting of a sudden and abrupt increase in blood pressure (BP) when a person stands up. QY, JX, HY http://en.volupedia.org/wiki/Orthostatic_hypertension 直立性高血压 10065508 orthostatic hypertension AE This is an AE which is defined by the coexistence of portal and pulmonary hypertension and is a serious complication of liver disease, present in 0.25 to 4% of all patients suffering from cirrhosis. QY, JX, HY http://en.volupedia.org/wiki/Portopulmonary_hypertension 肺移植性高血压 10067281 portopulmonary hypertension AE This is an AE which is the development of new hypertension in a pregnant woman after 20 weeks' gestation without the presence of protein in the urine or other signs of pre-eclampsia. QY, JX, HY http://en.volupedia.org/wiki/Gestational_hypertension 妊娠高血压 10036563 pregnancy induced hypertension AE This is an AE which is a condition in which high blood pressure is caused by the kidneys' hormonal response to narrowing of the arteries supplying the kidneys. QY, JX, HY http://en.volupedia.org/wiki/Renovascular_hypertension 肾性高血压 10038464 renal hypertension AE This is an AE which is defined as an elevated systolic blood pressure (SBP). QY, JX, HY http://en.volupedia.org/wiki/Systolic_hypertension 收缩期高血压 10042957 systolic hypertension AE This is an AE which is a form of labile hypertension in which people exhibit a blood pressure level above the normal range, in a clinical setting, although they do not exhibit it in other settings. QY, JX, HY http://en.volupedia.org/wiki/White_coat_hypertension 白大衣高血压 10051581 white coat hypertension AE This is an AE which is a usually benign vascular tumor occurs on intracranialderived from blood vessel cell types . QY, JX, HY http://en.volupedia.org/wiki/Hemangioma 颅内血管瘤 10022759 intracranial haemangioma AE This is an AE which occurs when there are unexpected changes in blood pressure. QY, JX, HY http://en.volupedia.org/wiki/Labile_hypertension 血压不稳定 10023533 labile blood pressure AE This is an AE which occurs when there are unexpected changes in blood pressure. QY, JX, HY http://en.volupedia.org/wiki/Labile_hypertension 高血压不稳定 10049079 labile hypertension AE This is an AE which is an ultrasound (US) visible lesion of the brain, which appears as echogenic streaks or spots in the arteries of thalamus and basal ganglia. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/21648326/ 连状纹状体血管病变 10073774 lenticulostriatal vasculopathy AE This is an AE which is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura and it is the most common vasculitis seen in clinical practice. QY, JX, HY http://en.volupedia.org/wiki/Cutaneous_small-vessel_vasculitis 白细胞性血管炎 10024377 leukocytoclastic vasculitis AE This is an AE which is a medical condition in which injury to the large or small intestine occurs due to not enough blood supply. QY, JX, HY http://en.volupedia.org/wiki/Intestinal_ischemia 肠系膜血管机能不全 10027401 mesenteric vascular insufficiency AE This is an AE which refers to the subset of disorders affecting the structure and function of the coronary microcirculation, is prevalent in patients across a broad spectrum of cardiovascular risk factors, and is associated with an increased risk of adverse events. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/30466521/ 微血管冠状动脉疾病 10072685 microvascular coronary artery disease AE This is an AE which is a cutaneous condition that presents as slowly growing, multiple, discrete but grouped, red to violaceous papules. QY, JX, HY http://en.volupedia.org/wiki/Multinucleate_cell_angiohistiocytoma 多核细胞血管组织细胞瘤 10077003 multinucleate cell angiohistiocytoma AE This is an AE which constitutes a prevalent, chronic, and progressive retinal degenerative disease of the macula that affects elderly people and cause central vision impairment. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/33153227/ 新生血管老年性黄斑变性 10071129 neovascular age-related macular degeneration AE This is an AE which is the natural formation of new blood vessels (neo- + vascular + -ization), usually in the form of functional microvascular networks, capable of perfusion by red blood cells, that form to serve as collateral circulation in response to local poor perfusion or ischemia. QY, JX, HY http://en.volupedia.org/wiki/Neovascularization 新血管化 10029113 neovascularisation AE This is an AE which is a skin condition characterized by crops of small, tender, erythematous nodules on the legs, mostly on the calves and shins. QY, JX, HY http://en.volupedia.org/wiki/Nodular_vasculitis 结节性血管炎 10029491 nodular vasculitis AE This is an AE which encompass a large and diverse group of underlying pathologies ranging from venous thromboembolism to congenital malformations to inflammatory vasculitides. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/26024602/ 肺血管疾病 10061474 pulmonary vascular disorder AE This is an AE which encompasses inflammation in the pulmonary vasculature with involved vessels varying in caliber from large elastic arteries to capillaries. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25836645/ 肺血管炎 10037457 pulmonary vasculitis AE This is an AE which is a disease characterized by a weeks-long course of thunderclap headaches, sometimes focal neurologic signs, and occasionally seizures. QY, JX, HY http://en.volupedia.org/wiki/Reversible_cerebral_vasoconstriction_syndrome 可逆性脑血管收缩综合征 10073240 reversible cerebral vasoconstriction syndrome AE This is an AE which is skin condition that is a typical feature of rheumatoid arthritis, presenting as peripheral vascular lesions that are localized purpura, cutaneous ulceration, and gangrene of the distal parts of the extremities. QY, JX, HY http://en.volupedia.org/wiki/Rheumatoid_vasculitis 类风湿性血管炎 10048628 rheumatoid vasculitis AE This is an AE which is an area of swelling (edema) of the lower layer of small bowel tissue just under the skin or mucous membranes. QY, JX, HY http://en.volupedia.org/wiki/Angioedema 小肠血管性水肿 10051401 small bowel angiedema AE This is an AE which are rare and constitute only 1% to 2% of all vascular neurologic pathologies. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/17493539/ 脊髓血管疾病 10061369 spinal vascular disorder AE This is an AE which is a form of dysautonomia characterized by an inappropriate drop in blood pressure while in the upright position. QY, JX, HY http://en.volupedia.org/wiki/Hypotension#Vasovagal_syncope 迷走性晕厥血管 10042777 syncope vasovagal AE This is an AE which refers to a recognized group of birth defects which tend to co-occur (see below). QY, JX, HY http://en.volupedia.org/wiki/VACTERL_association 血管综合征 10066022 vacterl syndrome AE This is an AE which is a skin condition characterized by fixed urticarial lesions that appear histologically as a vasculitis. QY, JX, HY http://en.volupedia.org/wiki/Urticarial_vasculitis 荨麻疹性血管炎 10048820 urticarial vasculitis AE This is an AE which is any of a range of lesions from a simple birthmark to a large tumor that may be disfiguring. QY, JX, HY http://en.volupedia.org/wiki/Vascular_anomaly 血管异常 10047050 vascular anomaly AE This is an AE which is a complex and highly regulated process that involves activation of cellular signaling pathways, circulating inhibitors of calcification, genetic factors, and hormones. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/25435520/ 血管钙化 10051753 vascular calcification AE This is an AE which means any disorder or disease of the brain vascular , especially chronic degenerative conditions. QY, JX, HY http://en.volupedia.org/wiki/Encephalopathy 血管性脑病 10063661 vascular encephalopathy AE This is an AE which is a surgical procedure performed to redirect blood flow from one area to another by reconnecting blood vessels. QY, JX, HY http://en.volupedia.org/wiki/Vascular_bypass 血管移植 10067740 vascular graft AE This is an AE which is the use of transplanted or prosthetic blood vessels in surgical procedures and after surgical appears complication. QY, JX, HY http://en.volupedia.org/wiki/Graft_(surgery) 血管移植并发症 10064252 vascular graft complication AE This is an AE which is an outdated term to describe certain types of headache which were thought to be related to blood vessel swelling and hyperemia as cause of pain. QY, JX, HY http://en.volupedia.org/wiki/Vascular_headache 血管性头痛 10047077 vascular headache AE This is an AE which is a devastating complication of acute knee dislocation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/24554457/ 血管损伤 10047080 vascular injury AE This is an AE which is a blood vessel or lymph vessel abnormality. Vascular malformations are one of the classifications of vascular anomalies, the other grouping is vascular tumors. QY, JX, HY http://en.volupedia.org/wiki/Vascular_malformation 血管畸形 10074979 vascular malformation AE This is an AE which is a tumor of vascular origin; a soft tissue growth that can be either benign or malignant, formed from blood vessels or lymph vessels. QY, JX, HY http://en.volupedia.org/wiki/Vascular_tumor 血管肿瘤 10055031 vascular neoplasm AE This is an AE which is when there is a local hematoma being contained by the surrounding tissue around an vascular artery. QY, JX, HY http://en.volupedia.org/wiki/Pseudoaneurysm 血管假性动脉瘤 10048975 vascular pseudoaneurysm AE This is an AE which is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. QY, JX, HY http://en.volupedia.org/wiki/Purpura 血管性紫癜 10047097 vascular purpura AE This is an AE which is a change of the human skin which affects its color, appearance, or texture and causes by vascular disease. QY, JX, HY http://en.volupedia.org/wiki/Rash 血管炎性皮疹 10047111 vasculitic rash AE This is an AE which is vasculitis (inflammation of the blood vessel wall) involving the brain and occasionally the spinal cord. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_vasculitis 脑血管炎 10047119 vasculitis cerebral AE This is an AE which is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. QY, JX, HY http://en.volupedia.org/wiki/Vasoconstriction 血管收缩 10047139 vasoconstriction AE This is an AE which is excess accumulation of fluid (edema) in the intracellular or extracellular spaces of the vasogenic brain. QY, JX, HY http://en.volupedia.org/wiki/Cerebral_edema 血管源性脑水肿 10067275 vasogenic cerebral edema AE This is an AE which is inflammation of the inner part of the nose that is not caused by an allergy. QY, JX, HY http://en.volupedia.org/wiki/Nonallergic_rhinitis 血管运动性鼻炎 10047145 vasomotor rhinitis AE This is an AE which is a postperfusion syndrome characterized by low systemic vascular resistance and a high cardiac output. QY, JX, HY http://en.volupedia.org/wiki/Vasoplegic_syndrome 血管麻痹综合征 10067080 vasoplegia syndrome AE This is an AE which refers to a condition in which an arterial spasm leads to vasoconstriction. QY, JX, HY http://en.volupedia.org/wiki/Vasospasm 血管痉挛 10047163 vasospasm AE This is an AE which is a type of arrhythmia. QY, JX, HY http://en.volupedia.org/wiki/Arrhythmia#Ventricular_arrhythmia 室性心律失常 10047281 ventricular arrhythmia AE This is an AE which is a device used in neurosurgery to treat hydrocephalus and relieve elevated intracranial pressure when the normal flow of cerebrospinal fluid (CSF) inside the brain is obstructed. QY, JX, HY http://en.volupedia.org/wiki/External_ventricular_drain 心室引流 10052947 ventricular drainage AE This is an AE which refers to a condition where the left atrium or right atrium of the heart is larger than would be expected. It can also affect both atria. QY, JX, HY http://en.volupedia.org/wiki/Atrial_enlargement 心室扩大 10079339 ventricular enlargement AE This is an AE which is a set of manifestations caused by the failure of the heart's function as a pump supporting the blood flow through the body; its signs and symptoms result from a structural and/or functional abnormality of the heart, that disrupts its filling with blood or its ejecting of it during each heart beat. QY, JX, HY http://en.volupedia.org/wiki/Heart_failure 心室衰竭 10060953 ventricular failure AE This is an AE which is an arrhythmia, more specifically a tachycardia affecting the ventricles with a rate over 250-350 beats/min, and one of the most indiscernible. QY, JX, HY http://en.volupedia.org/wiki/Ventricular_flutter 心室扑动 10047294 ventricular flutter AE This is an AE which is thickening of the walls of a ventricle (lower chamber) of the heart. QY, JX, HY http://en.volupedia.org/wiki/Ventricular_hypertrophy 心室肥大 10047295 ventricular hypertrophy AE This is an AE which is one of the classifications of movement disorders causes by ventricular disease, and refers to decreased bodily movement . QY, JX, HY http://en.volupedia.org/wiki/Hypokinesia 心室运动减退 10050510 ventricular hypokinesia AE This is an AE which is a defect in the ventricular septum, the wall dividing the left and right ventricles of the heart. QY, JX, HY http://en.volupedia.org/wiki/Ventricular_septal_defect 室间隔缺损 10047298 ventricular septal defect AE This is an AE which consists of multiple, radially oriented dilated medullary veins that drain into a transparenchymal venous stem. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/1442406/ 脑静脉血管瘤 10053485 venous angioma of brain AE This is an AE which is a group of disorders that destroy blood vessels by inflammation caused by viral. QY, JX, HY http://en.volupedia.org/wiki/Vasculitis 病毒性血管炎 10056281 viral vasculitis AE This is an AE which is a rare hemorrhagic diathesis, with clinical symptoms similar to those associated with the inherited form von Willebrand disease and syndrome is characterized by a lack of previous bleeding symptoms, negative familial history, and occurrence in a relatively older age. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/28028990/ 获得性血管性血友病 10069495 acquired von willebrand's disease AE This is an AE which is small, reddish brown or even flesh-colored, smooth, shiny, 0.1 to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks. QY, JX, HY http://en.volupedia.org/wiki/Angiofibroma 血管纤维瘤 10002429 angiofibroma AE This is an AE which is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement. QY, JX, HY http://en.volupedia.org/wiki/Angioimmunoblastic_T-cell_lymphoma 血管免疫母细胞性t细胞淋巴瘤 10002449 angioimmunoblastic t-cell lymphoma AE This is an AE which is the most common benign tumour of the kidney. QY, JX, HY http://en.volupedia.org/wiki/Angiomyolipoma 血管肌脂肪瘤 10051810 angiomyolipoma AE This is an AE which is a rare and aggressive cancer that starts in the endothelial cells that line the walls of blood vessels or lymphatic vessels. QY, JX, HY http://en.volupedia.org/wiki/Angiosarcoma 恶性血管皮内细胞瘤 10002476 angiosarcoma AE This is an AE which is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. QY, JX, HY http://en.volupedia.org/wiki/Angiotensin-converting_enzyme 血管紧张素转换酶 10050289 angiotensin converting enzyme AE This is an AE which is the creation of new blood vessels in the choroid layer of the eye. QY, JX, HY http://en.volupedia.org/wiki/Choroidal_neovascularization 脉络膜新生血管形成 10060823 choroidal neovascularisation AE This is an AE which is any disease that has the connective tissues of the body as a target of pathology. QY, JX, HY http://en.volupedia.org/wiki/Connective_tissue_disease 胶原血管病 10009905 collagen-vascular disease AE This is an AE which can be arbitrarily divided into micro- and macrovascular complications, the major microvascular complications being nephropathy, retinopathy and neuropathy. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/9315387/ 糖尿病性血管疾病 10061815 diabetic vascular disorder AE This is an AE which is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy). QY, JX, HY http://en.volupedia.org/wiki/Eosinophilic_granulomatosis_with_polyangiitis 嗜酸性肉芽肿伴多血管炎 10078117 eosinophilic granulomatosis with polyangiitis AE This is an AE which is the rupturing (lysis) of intravascular red blood cells (erythrocytes) and the release of their contents (cytoplasm) into surrounding fluid (e.g. blood plasma) . QY, JX, HY http://en.volupedia.org/wiki/Hemolysis 血管内溶血 10022822 intravascular haemolysis AE This is an AE which is a rare, benign tumor. It may mimic an angiosarcoma, with lesions that are red or purplish 5-mm to 5-cm papules and deep nodules on the head, neck, or upper extremities. QY, JX, HY http://en.volupedia.org/wiki/Intravascular_papillary_endothelial_hyperplasia 血管内乳头状内皮增生 10060711 intravascular papillary endothelial hyperplasia AE This is an AE which is the natural formation of new iris blood vessels (neo- + vascular + -ization), usually in the form of functional microvascular networks, capable of perfusion by red blood cells, that form to serve as collateral circulation in response to local poor perfusion or ischemia. QY, JX, HY http://en.volupedia.org/wiki/Neovascularization 虹膜新生血管化 10065630 iris neovascularisation AE This is an AE which is a rare anatomical variant in which the aortic arch is on the right side rather than on the left. During normal embryonic development, the aortic arch is formed by the left fourth aortic arch and the left dorsal aorta. QY, JX, HY http://en.volupedia.org/wiki/Right-sided_aortic_arch 右主动脉弓 10067407 right aortic arch AE This is an AE which occurs late after the modified Fontan procedure is frequently associated with low output states, supraventricular arrhythmias, and atrial thrombus formation. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/9240287/ 右心房扩张 10067282 right atrial dilatation AE This is an AE which is a form of cardiomegaly, or heart enlargement. QY, JX, HY http://en.volupedia.org/wiki/Right_atrial_enlargement 右心房扩大 10058227 right atrial enlargement AE This is an AE which may can result in a lack of emotional prosody or intonation when speaking. Right hemisphere damage also has grave effects on understanding discourse and have a reduced ability to generate inferences, comprehend and produce main concepts, and a reduced ability to manage alternative meanings. QY, JX, HY http://en.volupedia.org/wiki/Lateralization_of_brain_function#Hemisphere_damage 右半球缺陷综合征 10075037 right hemisphere deficit syndrome AE This is an AE which is defined as a peak echo-Doppler gradient at least 30 mmHg across the right ventricular outflow tract (RVOT) and included any postoperative surgical or percutaneous interventional procedure to address any right-sided outflow obstruction. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/17339117/ 右心室流出道梗阻 10064195 right ventricle outflow tract obstruction AE This is an AE which is an accepted indication of ASD closure and several studies have reported that transcatheter ASD closure results in RV remodeling and exercise capacity improvement . QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32410917/ 右心室扩张 10074222 right ventricular dilatation AE This is an AE which is a form of cardiomegaly, or heart enlargement. QY, JX, HY http://en.volupedia.org/wiki/Right_atrial_enlargement 右心室增大 10050582 right ventricular enlargement AE This is an AE which is a condition defined by an abnormal enlargement of the cardiac muscle surrounding the right ventricle. QY, JX, HY http://en.volupedia.org/wiki/Right_ventricular_hypertrophy 右心室肥大 10050326 right ventricular hypertrophy AE This is an AE which is an abnormal, congenital heart murmur caused by subaortic stenosis (SAS). QY, JX, HY http://en.volupedia.org/wiki/Subvalvular_aortic_stenosis_(canine) 瓣下主动脉瓣狭窄 10042431 subvalvular aortic stenosis AE This is an AE which is a congenital obstructive narrowing of the aorta just above the aortic valve and is the least common type of aortic stenosis. QY, JX, HY http://en.volupedia.org/wiki/Supravalvular_aortic_stenosis 瓣上主动脉瓣狭窄 10042598 supravalvular aortic stenosis AE This is an AE which has been defined by Abbot as a condition in which the arterial vessels in the greater circulation remain abnormally small. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/13617202/ 主动脉发育不全 10049209 aorta hypoplasia AE This is an AE which is the thickening, hardening, and loss of elasticity of the walls of arteries on aortic. QY, JX, HY http://en.volupedia.org/wiki/Arteriosclerosis 主动脉硬化 10065558 aortic arteriosclerosis AE This is an AE which is the abnormal sound generated by turbulent flow of blood in an aortic artery due to either an area of partial obstruction or a localized high rate of blood flow through an unobstructed aortic bruit artery. QY, JX, HY http://en.volupedia.org/wiki/Bruit 主动脉杂音 10051832 aortic bruit AE This is an AE which refers to the widening of luminal diameter in aortic blood vessels. QY, JX, HY http://en.volupedia.org/wiki/Dilation 主动脉扩张 10057453 aortic dilatation AE This is an AE which could interfere with the classification of TEVAR complications. QY, JX, HY https://pubmed.ncbi.nlm.nih.gov/32069982/ 主动脉延长 10065510 aortic elongation AE This is an AE which clotted blood which lines most aortic aneurysms can break off and result in an embolus. QY, JX, HY http://en.volupedia.org/wiki/Aortic_aneurysm 主动脉栓塞 10002897 aortic embolus AE This is an AE wh