Product version Darrell R. Abernethy Elizabeth Blair Izabela Birsanescu Keith Burkhart Luca Toldo Mathias Brochhausen Sydni Joubran "Asiyah" Yu Lin Abra Guo Barry Smith Bingjian Yang David Ameriguian Desikan Jagannathan Edison Ong Jessica DeGuise Jiangan "Hardy" Xie Jiangan Xie Kelly Yang Kevin Mo Ling Wan Liwei Wang Meiu Wong Noemi Garg Qingping Liu Qiuyue Yang Rebecca Racz Shelley Zhang Sirarat Sarntivijai Sydni Joubran Yongqun "Oliver" He (YH) Zuoshuang "Allen" Xiang 2022-8-15 The Ontology of Adverse Eventsy (OAE) is a biomedical ontology in the domain of adverse events. OAE aims to standardize adverse event annotation, integrate various adverse event data, and support computer-assisted reasoning. OAE is a community-based ontology. Its development follows the OBO Foundry principles. Vaccine adverse events have been used as an initial testing use case. OAE also studies adverse events associated with the administration of drug and nutritional products, the operation of surgeries, and the usage of medical devices, etc. OWL-DL An ontology for the annotation of the adverse event domain. OAE: Ontology of Adverse Events 1.2.47 Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label BFO OWL specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label BFO CLIF specification label editor preferred label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label example A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> example of usage example of usage has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot OBI_0000281 has curation status has curation status definition definition textual definition The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition definition textual definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obfoundry.org/obo/obi> IAO:0000116 uberon editor_note 1 editor_note editor note editor note term editor Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition editor term editor term editor alternative term An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> alternative term alternative term definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source definition source curator note An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg IAO:0000232 uberon curator_notes 1 curator_notes curator note curator note curator notes imported from For external terms/classes, the ontology from which the term was imported PERSON:Alan Ruttenberg PERSON:Melanie Courtot GROUP:OBI:<http://purl.obolibrary.org/obo/obi> imported from imported from expand expression to expand expression to expand assertion to expand assertion to elucidation person:Alan Ruttenberg Person:Barry Smith Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms elucidation elucidation has associated axiom(nl) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom associated with a term expressed using natural language has associated axiom(nl) has associated axiom(nl) has associated axiom(fol) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom expressed in first order logic using CLIF syntax has associated axiom(fol) has associated axiom(fol) has axiom label YH, JX a chinese translation represents a chinese translation of the existing term. Chinese translation Chinese translation The AE 'cough AE' has the 'label of AE outcome' of 'cough'; 'infection AE' has the 'label of AE outcom' of 'infection'. an annotation property that represents the label of an adverse event Yongqun Oliver He, Jiangan Hardy Xie label of adverse event outcome adverse event outcome adverse event outcome has_MedDRA_id has_MedDRA_id An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. temporal interpretation temporal interpretation https://github.com/oborel/obo-relations/wiki/ROAndTime tooth SubClassOf 'never in taxon' value 'Aves' x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL. Chris Mungall ?X DisjointWith RO_0002162 some ?Y never in taxon An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon. taxonomic class assertion taxonomic class assertion S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. RO:0002174 uberon dubious_for_taxon 1 1 dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost dubious_for_taxon S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S RO:0002175 applicable for taxon uberon present_in_taxon 1 1 present_in_taxon present_in_taxon An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL. logical macro assertion logical macro assertion https://github.com/oborel/obo-relations/wiki/ShortcutRelations A logical macro assertion whose domain is an IRI for a class The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL logical macro assertion on a class logical macro assertion on a class A logical macro assertion whose domain is an IRI for a property logical macro assertion on a property logical macro assertion on a property logical macro assertion on an object property logical macro assertion on an object property logical macro assertion on an annotation property logical macro assertion on an annotation property relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q' Chris Mungall is direct form of An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. UBPROP:0000001 uberon external_definition 1 external_definition This annotation property may be replaced with an annotation property from an external ontology such as IAO external_definition A textual description of an axiom loss in this ontology compared to an external ontology. UBPROP:0000002 uberon axiom_lost_from_external_ontology 1 axiom_lost_from_external_ontology This annotation property may be replaced with an annotation property from an external ontology such as IAO axiom_lost_from_external_ontology Notes on the homology status of this class. UBPROP:0000003 uberon homology_notes 1 homology_notes This annotation property may be replaced with an annotation property from an external ontology such as IAO homology_notes An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info. UBPROP:0000005 uberon external_comment 1 external_comment This annotation property may be replaced with an annotation property from an external ontology such as IAO external_comment UBPROP:0000006 uberon implements_design_pattern 1 implements_design_pattern implements_design_pattern Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. UBPROP:0000007 uberon has_relational_adjective 1 has_relational_adjective has_relational_adjective Notes on the how instances of this class vary across species. UBPROP:0000008 uberon taxon_notes 1 taxon_notes taxon_notes Notes on the evolved function of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000009 uberon function_notes 1 function_notes function_notes Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 uberon structure_notes 1 structure_notes structure_notes Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 uberon development_notes 1 development_notes development_notes Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 uberon external_ontology_notes 1 external_ontology_notes external_ontology_notes Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000013 uberon terminology_notes 1 terminology_notes terminology_notes UBPROP:0000100 uberon is_count_of 1 is_count_of is count of A property used in conjunction with repeated_element_number to indicate an axis and directionality along that axis. If P preceding_element_is R, and P is_count_of S, and X P N, and X' P N+1, then it follows that every X R some X', and the class expression [S and R some X' and inv(R) some X] is empty (i.e. X is followed by X', with no intermediates) UBPROP:0000101 uberon preceding_element_is 1 preceding_element_is preceding element is x pharyngeal_arch_number N if and only if (i) x is a pharyngeal arch, and (ii) x is ancestrally pharyngeal arch number N in a series of pharyngeal arches repeated along a antero-posterior axis, with arch_number 1 being the mandibular arch. gill arch N = PA N-2. the term branchial_arch is ambiguous. UBPROP:0000103 uberon pharyngeal_arch_number 1 pharyngeal_arch_number pharyngeal arch number x phalanx_number N if and only if (i) x is a phalanx, and (ii) x is phalanx number N in a series of phalanges repeated along an prixomo-distal axis, with phalanx_number 1 being the proximalmost phalanx. Note that in humans, the distalmost phalanx has phlanax_number 3, except in ray_number 1, where the distalmost has phalanx_number 2 UBPROP:0000105 uberon phalanx_number 1 phalanx_number Most land mammals including humans have a 2-3-3-3-3 formula in both the hands (or paws) and feet. Primitive reptiles typically had the formula 2-3-4-4-5, and this pattern, with some modification, remained in many later reptiles and in the mammal-like reptiles. The phalangeal formula in the flippers of cetaceans (marine mammals) is 2-12-8-1 phalanx number FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term UBPROP:0000202 uberon fma_set_term 1 fma_set_term fma_set_term eco subset CUMBO developmental_classification A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes. EFO slim derived from the union of EHDAA2 and EMAPA - still to be checked functional_classification Subset consisting of classes creating for grouping purposes A grouping class that depends on an assumption of homology between subclasses classes that have some inconsistency with FMA somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads abstract class brought in to group ontology classes but not informative organs, excluding individual muscles and skeletal elements Phenotype slim Uberon slim - subset that excludes obscure terms and deep compositional terms abstract upper-level terms not directly useful for analysis core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO uberon dc-contributor 1 dc-contributor contributor Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content. An account of the content of the resource. Description Description The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system. A reference to a resource from which the present resource is derived. Source Source subset_property has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym in_subset shorthand label label label uberon foaf-depicted_by 1 foaf-depicted_by depicted_by is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime part_of BFO:0000050 uberon part_of part_of part of part of http://www.obofoundry.org/ro/#OBO_REL:part_of has part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime has_part BFO:0000051 uberon has_part has_part has part has part realized in this disease is realized in this disease course this fragility is realized in this shattering this investigator role is realized in this investigation is realized by realized_in [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realized in realizes this disease course realizes this disease this investigation realizes this investigator role this shattering realizes this fragility to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realizes preceded by X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 is preceded by takes place after uberon preceded_by preceded_by preceded by preceded_by precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. BFO:0000063 uberon precedes precedes precedes precedes occurs in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t occurs_in unfolds in unfolds_in Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant occurs in site of [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant contains process x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer cjm 2009-07-31T02:15:46Z BSPO:0000096 uberon anterior_to anterior_to anterior_to x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal). BSPO:0000097 uberon distal_to distal_to distal_to x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000098 uberon dorsal_to dorsal_to dorsal_to x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. BSPO:0000099 caudal_to uberon posterior_to posterior_to posterior_to x proximal_to y iff x is closer to the point of attachment with the body than y. BSPO:0000100 uberon proximal_to proximal_to proximal_to x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000102 uberon ventral_to ventral_to ventral_to Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. BSPO:0000107 uberon deep_to deep_to deep_to Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. BSPO:0000108 uberon superficial_to superficial_to superficial_to X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion. BSPO:0000120 uberon in_left_side_of in_left_side_of in_left_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion. BSPO:0000121 uberon in_right_side_of in_right_side_of in_right_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. BSPO:0000122 uberon in_posterior_side_of in_posterior_side_of in_posterior_side_of X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. BSPO:0000123 uberon in_anterior_side_of in_anterior_side_of in_anterior_side_of X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. BSPO:0000124 uberon in_proximal_side_of in_proximal_side_of in_proximal_side_of X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. BSPO:0000125 uberon in_distal_side_of in_distal_side_of in_distal_side_of X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure BSPO:0000126 uberon in_lateral_side_of in_lateral_side_of in_lateral_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y BSPO:0001106 uberon proximalmost_part_of proximalmost_part_of proximalmost_part_of X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y BSPO:0001108 uberon distalmost_part_of distalmost_part_of distalmost_part_of a preceded_by relation that indicates that one process (e.g., an adverse event) is causally preceded by (induced by) another process (e.g., a medical intervention) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. Yongqun He induced by induced_by the relation indicates that one process (e.g., a medical intervention) induces another process (e.g., an adverse event) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. This is an inverse relation of the term "induced_by". YH, AG induces This is a tentative relation. We need to get this role from another ontology later. Oliver -- BFO 2.0 has this role 'is role of':: http://purl.obolibrary.org/obo/BFO_0000081 Once we get BFO 2.0, we can replace with this role. Oliver role_of An electrocardiogram qt prolonged AE is_evidence_of arrhythmia AE; arrhythmia AE is_evidence_of cardiomyopathy AE; fever AE is_evidence_of inflammation AE; fever AE is_evidence_of viral infection AE; plural effusion AE is_evidence_of cardiac disorder AE. AE1 is_evidence_of AE2 if and only if: given an adverse event instance ae1 that instantiates class AE1 (e.g., electrocardiogram qt prolonged AE) and another adverse event instance ae2 that instantiates class AE2 (e.g., arrhythmia AE), both ae1 and ae2 are adverse events that are clinically observed after a medical intervention (at time t0) on the same patient. The presence of ae1 is supported by priori knowledge of medicine to imply the presence of ae2 with some probability P (P is NOT always 1, thus transitivity does not apply to is_evidence_of relation. AE1 is_evidence_of AE2 and AE2 is_evidence_of AE3 DOES NOT imply AE1 is_evidence_of AE3). The instance ae1 and ae2 are observed or detected at time t1 and t2, respectively. The biological onset time for ae1 or ae2 may occur before t1 or t2. The t1 and t2 can be the same time point or different time points. This represents a relation between two adverse events AE1 and AE2. However, AE1 may be an evidence of another adverse event AE3, and a dfferent adverse event AE4 may also be an evidence of the same AE2. SS, YH, YL is evidence of An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased. an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. This is a shortcut relation of the following full version: 'has participant' some (participant 'has quality' ) in: process 'has participant' some (participant 'has quality' some quality) Yongqun He has participant quality a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. Yongqun He adverse event occurs in AE occurs in A shortcut relation that represents the full path of ‘has participant’ some participant that ‘participates in’ some process. Yongqun He has participant undergoing a specific 'preceded by' object property that has a domain of an adverse event. Yongqun He adverse event preceded by bearer of this apple is bearer of this red color this vase is bearer of this fragility a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of is bearer of bearer of has participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant this apple has quality this red color a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. has_quality has quality this person has role this investigator role (more colloquially: this person has this role of investigator) a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. has_role has role RO:0001015 uberon location_of location_of location_of RO:0001025 uberon located_in located_in located_in RO:0002002 uberon has_boundary has_boundary has boundary FMA:85999 dbprop:nerve RO:0002005 nerve supply uberon innervated_by innervated_by http://code.google.com/p/obo-relations/issues/detail?id=6 innervated_by RO:0002007 uberon bounding_layer_of bounding_layer_of A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. bounding layer of David Osumi-Sutherland <= Primitive instance level timing relation between events before or simultaneous with Relation between occurrents, shares start and end boundaries. David Osumi-Sutherland RO:0002082 coincides_with is_equal_to uberon simultaneous_with simultaneous_with t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) simultaneous with simultaneous_with David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) David Osumi-Sutherland starts_at_end_of A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]. RO:0002087 directly preceded by is directly preceded by is immediately preceded by starts_at_end_of uberon immediately_preceded_by immediately_preceded_by X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately preceded by immediately_preceded_by David Osumi-Sutherland ends_at_start_of meets X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) immediately precedes David Osumi-Sutherland io X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y)) starts during David Osumi-Sutherland d during X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) happens during David Osumi-Sutherland o overlaps X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). ends during x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) overlaps RO:0002134 uberon innervates innervates http://code.google.com/p/obo-relations/issues/detail?id=6 innervates RO:0002150 uberon continuous_with continuous_with continuous_with RO:0002158 uberon homologous_to homologous_to homologous_to Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. RO:0002170 uberon connected_to connected_to Connection does not imply overlaps. connected to Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect) RO:0002176 uberon connects connects connects RO:0002177 uberon attaches_to_part_of attaches_to_part_of attaches_to_part_of relation between an artery and the structure is supplies with blood. FMA:86003 RO:0002178 arterial supply of uberon supplies supplies source: FMA supplies RO:0002179 drains blood from drains from uberon drains drains source: Wikipedia drains RO:0002202 uberon develops_from develops_from develops_from RO:0002203 uberon develops_into develops_into develops_into x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y RO:0002219 uberon surrounded_by surrounded_by surrounded_by x adjacent_to y iff: x and y share a boundary RO:0002220 uberon adjacent_to adjacent_to adjacent_to inverse of surrounded_by RO:0002221 uberon surrounds surrounds surrounds Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to Relation between occurrents, shares a start boundary with. RO:0002223 uberon starts starts starts Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall started by RO:0002224 uberon starts_with starts_with starts with starts with Relation between occurrents, shares an end boundary with. RO:0002229 finishes uberon ends ends ends x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall finished by RO:0002230 uberon ends_with ends_with ends with ends with RO:0002254 uberon has_developmental_contribution_from has_developmental_contribution_from has developmental contribution from t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. RO:0002256 uberon developmentally_induced_by developmentally_induced_by sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F) developmentally_induced_by RO:0002258 uberon developmentally_preceded_by developmentally_preceded_by developmentally preceded by RO:0002285 uberon developmentally_replaces developmentally_replaces developmentally_replaces example of usage: every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062); an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists. Chris Mungall results in formation of A mereological relationship or a topological relationship Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships mereotopologically related to RO:0002351 uberon has_member has_member has member FMA:85990 RO:0002371 uberon attaches_to attaches_to attaches_to we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve FMA:85994 RO:0002380 uberon branching_part_of branching_part_of branching_part_of x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y RO:0002385 uberon has_potential_to_developmentally_contribute_to has_potential_to_developmentally_contribute_to has potential to developmentally contribute to x has the potential to develop into y iff x develops into y or if x is capable of developing into y RO:0002387 uberon has_potential_to_develop_into has_potential_to_develop_into has potential to develop into RO:0002433 uberon contributes_to_morphology_of contributes_to_morphology_of contributes to morphology of x composed_primarily_of y iff: more than half of the mass of x is made from parts of y UBREL:0000002 RO:0002473 uberon composed_primarily_of composed_primarily_of composed primarily of Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. BFO:0000068 RO:0002488 begins_to_exist_during uberon existence_starts_during existence_starts_during existence starts during Relation between continuant and occurrent, such that c comes into existence at the start of p. RO:0002489 uberon existence_starts_with existence_starts_with existence starts with Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. BFO:0000069 RO:0002492 ceases_to_exist_during uberon existence_ends_during existence_ends_during existence ends during Relation between continuant and occurrent, such that c ceases to exist at the end of p. RO:0002493 uberon existence_ends_with existence_ends_with existence ends with RO:0002494 transforms from uberon transformation_of transformation_of transformation of RO:0002495 direct_transformation_of immediately transforms from uberon immediate_transformation_of immediate_transformation_of immediate transformation of RO:0002496 uberon existence_starts_during_or_after existence_starts_during_or_after existence starts during or after RO:0002497 uberon existence_ends_during_or_before existence_ends_during_or_before existence ends during or before RO:0002507 uberon has_material_contribution_from has_material_contribution_from has material contribution from A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. RO:0002551 uberon has sekeletal support has supporting framework has_skeleton has_skeleton has skeleton RO:0002569 uberon has_branching_part has_branching_part has_branching_part RO:0002572 uberon luminal_space_of luminal_space_of luminal space of RO:0002576 uberon skeleton_of skeleton_of skeleton of RO:0003000 uberon produces produces produces RO:0003001 uberon produced_by produced_by produced_by x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. uberon anteriorly_connected_to anteriorly connected to carries uberon channel_for channel for uberon channels_from channels_from uberon channels_into channels_into x is a conduit for y iff y passes through the lumen of x. uberon conduit_for conduit for x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. uberon distally_connected_to distally connected to uberon evolved_from Status: experimental evolved_from uberon existence_starts_and_ends_during existence starts and ends during uberon extends_fibers_into extends_fibers_into X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides. uberon in_central_side_of in_central_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. uberon posteriorly_connected_to posteriorly connected to uberon protects protects x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. uberon proximally_connected_to proximally connected to uberon subdivision_of placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B subdivision of . uberon transitively_anteriorly_connected_to transitively anteriorly connected to uberon transitively_connected_to transitively_connected to . uberon transitively_distally_connected_to transitively distally connected to . uberon transitively_proximally_connected_to transitively proximally connected to A data property that indicates that a material entity has a particular size. Yongqun He has size A ulcer has a diameter in cm some specific decimal length A 'has size' object property that indicates a material entity of round shape has a diameter of a particular length with the cm (centimeter) unit. Yongqun He has diameter in cm entity Entity Julius Caesar Verdi’s Requiem the Second World War your body mass index BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) entity continuant Continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] continuant occurrent Occurrent An entity that has temporal parts and that happens, unfolds or develops through time. BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] occurrent ic IndependentContinuant a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism the bottom right portion of a human torso the interior of your mouth A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] independent continuant t-region TemporalRegion Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] temporal region process Process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process disposition Disposition an atom of element X has the disposition to decay to an atom of element Y certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocytosis and exocytosis BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] disposition realizable RealizableEntity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] realizable entity quality Quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality sdc SpecificallyDependentContinuant Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] specifically dependent continuant role Role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role object-aggregate ObjectAggregate a collection of cells in a blood biobank. a swarm of bees is an aggregate of members who are linked together through natural bonds a symphony orchestra an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team) defined by fiat: the aggregate of members of an organization defined through physical attachment: the aggregate of atoms in a lump of granite defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container defined via attributive delimitations such as: the patients in this hospital the aggregate of bearings in a constant velocity axle joint the aggregate of blood cells in your body the nitrogen atoms in the atmosphere the restaurants in Palo Alto your collection of Meissen ceramic plates. An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee). ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158. b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004]) (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] object aggregate site Site Manhattan Canyon) a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] site object Object atom cell cells and organisms engineered artifacts grain of sand molecule organelle organism planet solid portions of matter star BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting. BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below). BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47 BFO 2 Reference: an object is a maximal causally unified material entity BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74 b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001]) object gdc GenericallyDependentContinuant The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] generically dependent continuant function Function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] function 1d-t-region OneDimensionalTemporalRegion the temporal region during which a process occurs. BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks). A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] one-dimensional temporal region material MaterialEntity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] material entity immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial entity r-quality RelationalQuality John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. a marriage bond, an instance of love, an obligation between one person and another. b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] relational quality 0d-t-region ZeroDimensionalTemporalRegion a temporal region that is occupied by a process boundary right now the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. temporal instant. A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] zero-dimensional temporal region A nervous system disease that is located_in nerves or nerve cells. ICD10CM:G62.9 NCI:C4731 SNOMEDCT_US_2018_03_01:193167000 SNOMEDCT_US_2018_03_01:264554005 SNOMEDCT_US_2018_03_01:277317008 SNOMEDCT_US_2018_03_01:277878001 SNOMEDCT_US_2018_03_01:386033004 SNOMEDCT_US_2018_03_01:42658009 UMLS_CUI:C0442874 peripheral neuropathy disease_ontology DOID:870 neuropathy Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. GO:0000004 GO:0007582 Wikipedia:Biological_process biological process physiological process biological_process GO:0008150 Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. biological_process Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo. biological_process accidental cell death necrosis GO:0008219 This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. cell death Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. GO:0008151 GO:0050875 cell physiology cellular physiological process cell growth and/or maintenance biological_process GO:0009987 cellular process A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. Wikipedia:Death biological_process GO:0016265 See also the biological process term 'apoptosis ; GO:0006915'. death A biological process that involves only one organism. janelomax 2012-09-19T15:05:24Z single organism process biological_process GO:0044699 single-organism process Any process that is carried out at the cellular level, occurring within a single organism. janelomax 2012-12-11T16:56:55Z biological_process GO:0044763 single-organism cellular process A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. necrosis cellular necrosis biological_process GO:0070265 Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'. necrotic cell death data item Data items include counts of things, analyte concentrations, and statistical summaries. a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers. 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum. 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym. 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/ JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief PERSON: Alan Ruttenberg PERSON: Chris Stoeckert PERSON: Jonathan Rees data data item information content entity Examples of information content entites include journal articles, data, graphical layouts, and graphs. A generically dependent continuant that is about some thing. 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ). information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity. PERSON: Chris Stoeckert OBI_0000142 information content entity textual entity Words, sentences, paragraphs, and the written (non-figure) parts of publications are all textual entities A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc. AR, (IAO call 2009-09-01): a document as a whole is not typically a textual entity, because it has pictures in it - rather there are parts of it that are textual entities. Examples: The title, paragraph 2 sentence 7, etc. MC, 2009-09-14 (following IAO call 2009-09-01): textual entities live at the FRBR (http://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records) manifestation level. Everything is significant: line break, pdf and html versions of same document are different textual entities. PERSON: Lawrence Hunter text textual entity hypothesis textual entity that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper 'Pilot clinical study to evaluate the anticoagulant activity of fucoidan', by Lowenthal et. al.PMID:19696660 A textual entity that expresses an assertion that is intended to be tested. 2009/09/28 Alan Ruttenberg. Fucoidan-use-case Person:Alan Ruttenberg hypothesis textual entity a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'. YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device. YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention. YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623. YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740. YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events. YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'. Yongqun He AE adverse reaction WEB: http://en.wikipedia.org/wiki/Adverse_event WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068 The OAE official website is: http://www.oae-ontology.org/. adverse event medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States," Reference: http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis. YH WEB: http://wiki.answers.com/Q/What_is_medical_intervention medical intervention an adverse event which is a causal adverse event, a pathological bodily process that is induced by a medical intervention. YH: The term 'causal adverse event' has the same meaning as we previously defined as 'adverse event'. Reference: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing as a way to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. YH adverse effect He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. YH: the term "adverse effect" has the same meaning of "causal adverse event". causal adverse event an adverse event that occurs after a vaccination. YH vaccine adverse event an adverse event that occurs after a drug administration YH, JX ADE ADR adverse drug reaction drug adverse event adverse drug event an adverse event that is associated with the usage of a medical device. YH This term is obsolete due to another term that has the same meaning. obsolete: medical device adverse event an adverse event that is associated with eating a medical food. YH medical food adverse event an adverse event that is induced by consuming a nutritional product. YH nutritional product adverse event an adverse event that is associated with consuming a dietary supplement. YH dietary supplement adverse event an adverse event that is associated with consuming an infant formula. YH infant formula adverse event a medical intervention where a patient is administered with a drug YH drug administration a medical intervention that uses a medical device YH medical device usage for medical intervention a medical intervention that uses a nutritional product YH consumption of nutritional product nutritional product usage a nutritional product usage that consumes a dietary supplement YH dietary supplement consumption a nutritional product usage that consumes infant formula YH consumption of infant formula a nutritional product usage that consumes medial food YH consumption of medical food an imaging investigation result abnormal AE that is characterized by an abnormal X-ray SS, YH, EB 10048065 X-ray result abnormal AE an X-ray result abnormal AE that has an outcome of an abnormality in chest X-ray test SS, YH 10008499 chest X-ray abnormal AE a haematoma AE that has an outcome of contusion. SS, YH WEB: http://en.wikipedia.org/wiki/Bruise 10050584 Contusion is a type of relatively minor hematoma of tissue in which capillaries and sometimes venules are damaged by trauma, allowing blood to seep into the surrounding interstitial tissues. contusion AE a digestive system AE which has an outcome of dry throat, which is a sensation of dryness in the throat. SS, YH 10013789 dry throat AE a skin discoloration AE which has an outcome of flushing, a sudden reddening of the face, neck, or upper chest SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003241.htm 脸红 10016825 flushing AE CTCAE:E13771 HPO: HP_0001033 NCIt:C26775 SIDER: C0016382 a pain AE where the pain reachs an extreme level. SS, YH, MW 10033425 pain in extremity AE CTCAE: E12512 HPO: HP_0009763 NCIt: C78515 SIDER: C0030196 a respiratory system AE which has an outcome of postnasal drip, which occurs when excessive mucus is produced by the nasal Mucosa. The excess mucus accumulates in the throat or back of the nose. SS, YH PDN UACS Upper Airway Cough Syndrome WEB: http://en.wikipedia.org/wiki/Post-nasal_drip 10036402 postnasal drip AE CTCAE: E13514 NCIt: C78566 a syndrome AE that is subclassified as five defined entities which represent clinical circumstances in which both the heart and the kidney are involved in a bidirectional injury and dysfunction via a final common pathway of cell-to-cell death and accelerated apoptosis mediated by oxidative stress. Types 1 and 2 involve acute and chronic cardiovascular disease (CVD) scenarios leading to acute kidney injury or accelerated chronic kidney disease. Types 2 and 3 describe acute and chronic kidney disease leading primarily to heart failure, although it is possible that acute coronary syndromes, stroke, and arrhythmias could be CVD outcomes in these forms of CRS. Finally, CRS type 5 describes a simultaneous insult to both heart and kidneys, such as sepsis, where both organs are injured simultaneously. SS, YH CRS WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030731/ 10068230 cardiorenal syndrome AE A bursal disorder AE that has an outcome of the symptom of bursitis. SS, YH bursa inflammation WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001456/ bursitis AE an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue. YH, RR, JX musculoskeletal and connective tissue disorder AE WEB: http://www.cdc.gov/niosh/programs/msd/ 10028395 A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture musculoskeletal or connective tissue AE CTCAE: E13872 A statistical test can be used to accept or reject the hypothesis. YH a hypothesis about the causal relation between an adverse event and a medical intervention. This term can be used to hypothesize and evaluate the relation between a medical intervention (e.g., drug, vaccination) and case reports from an adverse event reporting system (e.g., VAERS). CAE hypothesis causal adverse event hypothesis a musculoskeletal system AE which has an outcome of bursal disorder YH bursal disorder AE a vaccine adverse event that is induced by an influenza vaccine. YH: This term is just used as an example of vaccine induced adverse events. Specific vaccine-associated and vaccine-induced adverse events are now represented with the Ontology of Vaccine Adverse Events (OVAE).: http://www.violinet.org/ovae/. YH influenza vaccine-induced adverse event an influenza vaccine adverse event that is induced by a killed influenza vaccine (KIV). YH KIV-induced adverse event A KIV-induced AE that results in a GBS. YH VAERS statistical data analysis There is little evidence to support a causal association between GBS and most vaccines. The evidence for a causal association is strongest for the swine influenza vaccine that was used in 1976-77. Studies of influenza vaccines used in subsequent years, however, have found small or no increased risk of GBS. Reference: http://www.ncbi.nlm.nih.gov/pubmed?term=19388722. KIV-induced GBS averse event in 1976-1977 a muscle pain AE that is induced by Afluria influenza vaccine administration YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced muscle ache AE a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. lethargy is sometimes reported as an extreme fatigue: http://the-difference-between.com/lethargy/fatigue they are sometimes regarded as synonyms: https://www.nlm.nih.gov/medlineplus/ency/article/003088.htm SS, YH, MW lethargy AE WEB: http://en.wikipedia.org/wiki/Fatigue_%28medical%29 10016256 10024264 fatigue AE CTCAE: E11098 (fatigue); CTCAE: E12709 (lethargy) HPO: HP_0003388 NCIt: C3036; NCIt: C78416 SIDER: C0015672 a microbiology and serology investigation result abnormal AE that has an outcome of CSF culture negative. The negative result means no bacteria, viruses, or fungi grew in the laboratory dish. YH: The negative result is normal. It is not an AE. SS, YH, EB CSF culture negative AE a lab test abnormal AE that has an outcome of an abnormal result in a blood cell lab test SS, YH blood cell lab test abnormal AE an eosinophil percentage abnormal AE that has an outcome of increased eosinophil percentage YH, EB 10052222 eosinophil percentage increased AE a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by an obstruction of the blood supply to the heart SS WEB: http://www.ncbi.nlm.nih.gov/mesh/68009203 心肌梗塞 10028596 myocardial infarction AE CTCAE: E10152 HPO: HP_0001658 NCIt: C27996 SIDER: C0027051 a neutrophil count abnormal AE that has an outcome of increased neutrophil count YH 10029368 neutrophil count increased AE HPO: HP_0011991 SIDER: NA an adverse event that shows a complication that occurs after a medical procedure such as a surgery. SS, YH post-procedural AE procedural disorder AE procedure AE procedural complication AE an adverse event that has an outcome of injury after a medical intervention. SS, YH 10022116 injury AE an injury AE which has an outcome of head injury SS, YH 10019196 head injury AE a behavior and neurological AE that has an abnormal outcome in social behavior SS, YH social behavior AE a social behavior AE that has an outcome of impaired work ability SS, YH impaired work ability AE an allergy AE which has an outcome of injection-site allergic reaction 10022095 injection-site allergic reaction AE a myelitis AE which has an outcome of myelitis transverse. Transverse myelitis (in Latin nomenclature: myelitis transversa) is a neurological disorder caused by an inflammatory process of the spinal cord, and can cause axonal demyelination. SS, YH WEB: http://en.wikipedia.org/wiki/Transverse_myelitis 10028527 myelitis transverse AE a skin adverse even that has an outcome of warm skin SS, YH skin warm AE Nystagmus AE is an eye AE that is a condition of involuntary eye movement, acquired in infancy or later in life, that may result in reduced or limited vision. Due to the involuntary movement of the eye, it is often called "dancing eyes". JX, LW, YH WEB: http://en.wikipedia.org/wiki/Nystagmus 10029864 nystagmus AE CTCAE:E12748 NCIt:C3282 眼球震颤 a dermatitis AE that has an outcome of dermatitis bullous SS, YH bullous pemphigoid AE 10012441 Bullous pemphigoid is a skin disorder characterized by large blisters. dermatitis bullous AE HPO: HP_0011123 SIDER: C0085932 a skin adverse event that is characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling. SS, YH, MW hot flash AE hot flashes AE hot flush AE 10020407 hot flushes AE CTCAE: E13781 HPO: HP_0008209 NCIt: C3109 SIDER: C0600142 a KIV-induced adverse event that has an outcome of Afluria-induced adverse event YH Afluria-induced adverse event an adverse event that results in the outcome of a tumor. mass AE nodule AE tumour AE 10026865 YH, RR tumor AE a respiratory system AE which has an outcome of wheezing, a high-pitched whistling sound made while breathing. SS, YH, MW WEB: http://www.mayoclinic.org/symptoms/wheezing/basics/definition/sym-20050764 10047924 wheezing AE CTCAE:E13605 NCIt:C78718 a behavior and neurological AE that has an outcome of weight bearing difficulty weight bearing difficulty is a behavior AE that results in difficulty in managing the amount of weight a patient puts on the leg on which surgery has been performed. In general, it is described as a percentage of the body weight, because each leg of a healthy person carries the full body weight when walking, in an alternating fashion. SS, YH WEB: http://en.wikipedia.org/wiki/Weight-bearing weight bearing difficulty AE A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment. Yongqun He, Sirarat Sarntivijai, Mathias Brochhausen, William Hogan, ‎Philip E. Empey http://en.wikipedia.org/wiki/Contraindication contraindication a drug administration that uses incorrect drug dose YH incorrect drug dose administration an Afluria-induced adverse event that has an outcome of Afluria-induced fever in child YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced fever AE in child an Afluria-induced adverse event that has an outcome of Afluria-induced cough in child YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced cough AE in child an Afluria-induced adverse event which has an outcome of Afluria-induced injection site pain YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced injection site pain AE an Afluria-induced adverse event that has an outcome of Afluria-induced injection site redness YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced injection site redness AE an Afluria-induced AE that has an outcome of Afluria-induced inject site swelling YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced inject site swelling AE an Afluria-induced adverse event that has an outcome of Afluria-induced headache YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced headache AE an adverse event that occurs systematically throughout the systemic circulation. This is different from local adverse event that is limited or a certain location. YH, JX systematic adverse event URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction systematic AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with pregnancy. prenatal AE WEB: https://en.wikipedia.org/wiki/Complications_of_pregnancy WEB: https://en.wikipedia.org/wiki/Prenatal_diagnosis YH, JX pregnancy AE a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event outcome appears. This is the time = 'time instant of an adverse event outcome observed' - 'time instant of medical intervention'. YH, XZ adverse event incubation time a procedure complication AE that occurs after a surgery. YH surgery AE surgery adverse event surgical procedure AE The key difference between a surgery and a procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. Technically speaking, a surgery is a specific type of procedure. A procedure is a broad general term that refers to any series of pre-defined steps that should be followed to achieve a desired result. Therefore, a “surgical procedure” is synonymous with a “surgery.” See more: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm. surgery adverse event Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. YH, SS surgical procedure WEB: http://en.wikipedia.org/wiki/Surgery WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm 10042609 surgery a sugery adverse event that has an outcome of pressure ulcer. YH surgery-induced bedsore AE surgery-induced decubitus ulcer AE surgery-induced pressure ulcer AE an adverse event which occurs in a metabolism process (including anabolism and catabolism), endocrine system, or exocrine system. SS, YH, JX metabolism, endocrine, and exocrine system AE 10027433 metabolism, endocrine or exocrine system AE MP: 0005266 an adverse event that occurs in clinical trial. YH clinical trial adverse event a termporal instant that is the time when a medical intervention occurs. YH time instant of medical intervention time at medical intervention a temporal instant that is the time when an outcome of an adverse event (e.g., fever) is observed. YH time instant of an adverse event outcome observed an influenza vaccine adverse event that is induced by a live attenuated influenza vaccine (LAIV). YH LAIV-induced adverse event an LAIV-induced adverse event that is caused by the FluMist LAIV. YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf FluMist-induced adverse event a FluMist-induced adverse event that has an outcome of FluMist-induced runny nose YH FluMist-induced runny nose AE a FluMist-induced AE that has an outcome of FluMist-induced nasal congestion YH FluMist-induced nasal congestion AE a planned process that is specifically a test conducted in a clinical laboratory. Rebecca Racz, Yongqun He medical laboratory test WEB: http://labmed.ascpjournals.org/content/40/2/105.full clinical laboratory test A FluMist-induced AE that has an outcome of sore throat YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf FluMist-induced sore throat AE in adult a tumore AE that results in the outcome of a benign tumor. YH benign tumor AE a tumore AE that results in the outcome of a malignant tumor. YH malignant tumor AE a sensory capability AE that resuls in an uncomfortable feeling. YH discomfort AE HPO: HP_0010832 SIDER: C0234215 a reproductive system AE that occurs on the female side. YH 10038604 female reproductive system AE a reproductive system AE that occurs on the male side. YH male reproductive system AE a cardiovascular disorder AE that has a cardiac disorder outcome. SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/heart+disease Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23091623 10007541 10061024 cardiac disorder AE HPO: HP_0001627 SIDER: C0018799 a cardiovascular disorder AE that has a vascular disorder outcome 10047065 vascular disorder AE a skin adverse event that results in an inflammation of skin SS, YH 10012431 dermatitis AE HPO: HP_0011123 SIDER: C0011603 a drug adverse event that is induced by aspirin. YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced adverse event an aspirin-induced adverse event that is induced by the aspirin drug Aspidrox. Aspidrox-induced adverse event an aspirin-induced adverse event that has an outcome of nausea YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced nausea AE an aspirin-induced adverse event that has an outcome of vomiting YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced vomiting AE an aspirin-induced adverse event that has an outcome of stomach pain YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced stomach pain AE an aspirin-induced adverse event that has an outcome of heartburn YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced heartburn AE an aspirin-induced adverse event that has an outcome of rash symptom. YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced rash AE a medical intervention that is used for therapeutic purpose YH therapeutic intervention YH a drug adverse event that is caused by a drug adiministration. Here a causal effect is established between the drug administration and the adverse event. causal adverse drug event a medical device adverse event that is induced or caused by a medical device. There is a causal relation between the adverse event and the usage of a medical device. YH adverse event induced by medical device an adverse event that is induced by a vaccination. YH vaccine-induced adverse event a surgery adverse event that is caused by a surgery. YH surgery-induced adverse event YH a nutritional product adverse event that has a causal assocition with the usage of the nutritional product. nutritional product-induced adverse event influenza like illness AE is an adverse event that has an outcome of a medical diagnosis of possible influenza or other illness causing a set of common symptoms SS, YH acute respiratory infection, ARI, flu-like syndrome WEB: http://en.wikipedia.org/wiki/Influenza-like_illness 10016791 influenza like illness AE HPO: HP_0005376 MDR: 10022004 SIDER: C0521839 a prediction process that allows prediction of a causal adverse event induced by a medical intervention. YH prediction of causal adverse event a prediction of causal adverse event that is induced by a vaccination. YH prediction of causal vaccine adverse event YH a pathogen infection adverse event that has an outcome of a fungal infection. 10017533 fungal infection AE HPO: HP_0002841 SIDER: C0026946 a prediction of causal adverse event that is induced by a drug administration. YH prediction of causal drug adverse event a prediction of causal adverse event that is induced by a usage of a medical device. YH prediction of causal medical device adverse event a prediction of causal adverse event that is induced by a surgery operation. YH prediction of causal surgery adverse event a planned process that leads to the identification of a causal relation between an existing adverse event and a medical intervention. YH determination of causal adverse event an identification of causal adverse event that is induced by a vaccination. YH determination of causal vaccine adverse event an identification of causal adverse event that is induced by a drug administration. YH determination of causal drug adverse event an identification of causal adverse event that is induced by a surgery. YH determination of causal surgery adverse event an identification of causal adverse event that is induced by a usage of a medical device. YH determination of causal medical device adverse event an intrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event. YH intrinsic factor of causal adverse event an extrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event. YH extrinsic factor of causal adverse event a role that is extrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include environment, diet, smoking, alcohol use, herbal product, drug-drug interaction. YH extrinsic factor of adverse event a role that is intrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include: age, race, organ dysfunction, disease, pregrancy, lactation, gender, and genetics. YH intrinsic factor of adverse event YH an extrinsic factor of adverse event that is from environment. environment factor of adverse event YH an intrinsic factor of adverse event that is the age of a patient. age factor of adverse event YH an intrinsic factor of adverse event that is the race of a patient. race factor of adverse event YH an intrinsic factor of adverse event that is the gender of a patient. gender factor of adverse event YH an intrinsic factor of adverse event that is the organ dysfunction of a patient. organ dysfunction factor of adverse event YH an intrinsic factor of adverse event that is a disease of a patient. disease factor of adverse event YH an intrinsic factor of adverse event that is the pregrancy of a patient. pregrancy factor of adverse event YH an intrinsic factor of adverse event that is the lactation of a patient. lactation factor of adverse event YH an intrinsic factor of adverse event that is the genetics of a patient. genetics factor of adverse event a planned process that reports an adverse event. YH adverse event reporting an adverse event reporting that is to report a vaccine adverse event. YH vaccine adverse event reporting an adverse event reporting that is to report a drug adverse event. YH drug adverse event reporting YH adverse event causality a quality that represents the level of causality between a medical intervention and an adverse event outcome. causality of adverse event YH a causality level of AE that is definite. definite AE causality YH a causality level of AE that is probable. probable AE causality YH a causality level of AE that is doubtful. doubtful causality of adverse event doubtful AE causality YH a causality level of AE that is possible. possible causality of adverse event potential causality of adverse event Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20. possible AE causality an adverse event reporting that is to report a medical device adverse event. YH medical device adverse event reporting an adverse event reporting that is to report a surgery adverse event. YH surgery adverse event reporting an identification of causal drug adverse event that is based on the Naranjo criteria. YH S.R. Ahmed. Adverse drug event monitoring at the Food and Drug Administration. J. Gen. Intern. Med. 18 (2003) 57-60. determination of causal drug adverse event by Naranjo criteria an identification of causal drug adverse event that is based on the Drug Interaction Probability Scale (DIPS). The DIPS uses a series of questions relating to the potential drug interaction to estimate a probability score. As a comparison, the Naranjo scale has proved to be useful for assessing the causality of adverse events, particularly for single-drug adverse drug reactions. DIPS involves in two drugs: the drug that is affected (object drug) and the drug that causes the change to the object drug (precipitant drug). YH J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680. determination of causal drug adverse event by DIPS an information content entity that lists one of 10 questions for the Drug Interaction Probability Scale (DIPS). YH J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680. DIPS question DIPS question 1: Are there previous credible reports of this interaction in humans? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 1 DIPS question 2: Is the observed interaction consistent with the known interactive properties of precipitant drug? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 2 DIPS question 3: Is the observed interaction consistent with the known interactive properties of object drug? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 3 DIPS question 4: Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 4 DIPS question 5: Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug? (if no dechallenge, use Unknown or NA and skip Question 6) Three answers: Yes (+1), No (-2), and Unk or NA (0) YH DIPS question 5 DIPS question 6: Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug? Three answers: Yes (+2), No (-1), and Unk or NA (0) YH DIPS question 6 DIPS question 7: Are there reasonable alternative causes for the event? Three answers: Yes (-1), No (+1), and Unk or NA (0) aConsider clinical conditions, other interacting drugs, lack of adherence, risk factors (eg, age, inappropriate doses of object drug). A NO answer presumes that enough information was presented so that one would expect any alternative causes to be mentioned. When in doubt, use Unknown or NA designation. YH DIPS question 7 DIPS question 8: Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction? Three answers: Yes (+1), No (0), and Unk or NA (0) YH DIPS question 8 DIPS question 9: Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug (other than drug concentrations from question 8)? Three answers: Yes (+1), No (0), and Unk or NA (0) YH DIPS question 9 DIPS question 10: Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 10 an AE causality score that is represented as a score of the Drug Interaction Probability Scale (DIPS). Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He Drug Interaction Probability Scale Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. DIPS score YH one of the Naranjo criteria that are frequently used for determination of causality for suspected adverse drug reactions (ADRs). Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Naranjo criterium DIPS question 1: Are there previous conclusive reports on this reaction? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 1 DIPS question 2: Did the adverse reaction appear after the suspected drug was administered? Three answers: Yes (+2), No (-1), and Don't Know (0) YH Naranjo criterium 2 DIPS question 3: Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 3 DIPS question 4: Did the adverse reaction reappear when the drug was readministered? Three answers: Yes (+2), No (-1), and Don't Know (0) YH Naranjo criterium 4 DIPS question 5: Are there alternative causes that could on their own have caused the reaction? Three answers: Yes (-1), No (+2), and Don't Know (0) YH Naranjo criterium 5 DIPS question 6: Did the reaction reappear when a placebo was given? Three answers: Yes (-1), No (+1), and Don't Know (0) YH Naranjo criterium 6 DIPS question 7: Was the drug detected in the blood (or other fluids) in concentrations known to be toxic? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 7 DIPS question 8: Was the reaction more severe when the dose was increased or less severe when the dose was decreased? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 8 DIPS question 9: Did the patient have a similar reaction to the same or similar drug in any previous exposure? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 9 DIPS question 10: Was the adverse event confirmed by any objective evidence? Three answers: Yes (+1), No (0), and Don't Know (0) YH Naranjo criterium 10 a score of the Naranjo adverse drug reaction probability scaling SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. WEB: http://livertox.nih.gov/Narajo.html Naranjo ADR probability score an adverse event causal association score that represents a probability that an adverse event is caused (induced) by a medical intervention. For an adverse event this is likely caused by a medical intervention, the causal adverse event (CAE) probabllity is in between 0 and 1. For a known causal adverse event, the CAE probabllity is 1. Alternatively, a CAE probability can be described as a scale that can go beyond the 0-1 range. For example, the Naranjo ADR probabililty score is a score that use scale with a wide range. YH CAE probability causal adverse event probability a peripheral neuropathy AE which has an outcome of sensory neuropathy that involves damage to nerves of the peripheral nervous system. YH, AG sensory neuropathy AE sensory neuropathy AE a sensory neuropathy AE which has an outcome of distal sensory neuropathy that involves damage to distal sensory nerves of the peripheral nervous system. YH, AG distal sensory neuropathy AE a distal sensory neuropathy AE that is chronic. YH, AG chronic distal sensory neuropathy AE a neuropathy AE that is induced by a drug administration AG, YH https://medlineplus.gov/ency/article/000700.htm drug-induced neuropathy AE Tremor AE is a behavior and neurological AE that has an outcome of an involuntary trembling or quivering, and muscle contraction and relaxation. SS, YH WEB: http://www.nlm.nih.gov/medlineplus/tremor.html 10044565 tremor AE CTCAE: E12837 HPO: HP_0001337 NCIt: C38038 SIDER: C0040822 a neuropathy AE which shows symptoms due to the damage to the autonomic nerves. This damage disrupts signals between the brain and portions of the autonomic nervous system, such as the heart, blood vessels and sweat glands. This can cause decreased or abnormal performance of one or more involuntary body functions. AG, YH WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy WEB: http://www.mayoclinic.org/diseases-conditions/autonomic-neuropathy/basics/definition/con-20029053 10061666 autonomic neuropathy AE HPO: HP_0002270 SIDER: C0259749 UMLS CUI: C0259749 a peripheral neuropathy AE which is caused by a damage to motor neurons AG, YH motor neuropathy AE A peripheral neuropathy AE which is characterized by damage to more than one nerve AG, YH, RR WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html 10036105 polyneuropathy AE HPO: HP_0001271 SIDER: C0152025 a neuropathy AE which is characterized by isolated damage of a single nerve AG, YH 10062203 mononeuropathy AE a peripheral neuropathy AE which affects extremities, such as, toes, fingers, hand and feet. AG, YH axonal neuropathy AE WEB: http://www.livestrong.com/article/184686-distal-neuropathy-symptoms/ distal neuropathy AE a nervous system AE that affects the neuronal cell body AG, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922643/ neuronopathy AE A neuritis AE which has an outcome of mononeuritis characterized by isolated inflammation of one nerve. AG, YH 10027910 mononeuritis AE A neuritis AE which has an outcome of polyneuritis characterized by isolated inflammation of many nerves. AG, YH polyneuritis AE a mononeuritis AE which has an outcome of mononeuritis multiplex which involves damage to at least two seperate unrelated nerve area. AG, YH mononeuritis multiplex AE a sensory neuropathy AE which has an outcome of acute sensory neuropathy that is characterized by rapid onset AG, YH acute sensory neuropathy AE a disposition that represents a risk factor associated with the occurrence of an adverse event. AG, YH AE risk factor A data item that is calculated as the number of patients realized with an adverse event beginning in an interval divided by the number of patients taking the same medical intervention within the same interval. The incidence thus indicates the number of newly occurring events over time. AG, YH WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf AE incidence rate a causal adverse drug event that is induced by a drug-drug interaction. YH, LT WEB: http://medical-dictionary.thefreedictionary.com/drug+interaction 10013710 causal adverse drug event due to drug-drug interaction a causal adverse drug event that is induced by a food-drug interaction. YH, LT causal adverse drug event due to food-drug interaction a causal adverse drug event that is induced bygenetic predisposition. YH, LT causal adverse drug event due to genetic predisposition a causal adverse drug event due to genetic predisposition that is specifically induced by SNP. YH, LT causal adverse drug event due to SNP a cardiovascular disorder AE that is a result of insufficient blood flow throughout the body. Shock often accompanies severe injury or illness. physiological shock AE shock WEB: http://en.wikipedia.org/wiki/Shock_%28circulatory%29 WEB: http://njcc.nl/sites/default/files/pdf/review-2_1.pdf (Lima A. Circulatory shock and peripheral circulatory failure: a historical perspective. Netherlands Journal of Critical Care. 2014. 18:6. 14-18) WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000039.htm 休克 10040560 Circulatory shock is not related to the emotional state of shock. Here is the Kumar and Parrilo definition of shock: "The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury". Reference: Kumar A, Parillo JE. Shock: pathophysiology, classification and approach to management. In: Parrillo JE, Parrillo JE, Bone RC (eds): Critical care medicine: Principles of diagnosis and management. Mosby: Toronto, 1995, pp 371-420. circulatory shock AE a psychiatric disorder AE that has an outcome of a loss of brain function and causes a long term and often gradual decrease in the ability to think and remember such that a person's daily functioning is affected. YH, MW WEB: https://en.wikipedia.org/wiki/Dementia 痴呆 10012272 Dementia is a loss of brain function that occurs with certain diseases or pathological processes. dementia AE HPO: HP_0000726 SIDER: C0497327 A vascular disorder AE that results in the presence of blood clot along the wall of a blood vessel, frequently causing vascular obstruction. Some authorities differentiate thrombus formation from simple coagulation or clot formation. SS, YH, MW 血栓症; 血栓生成 10043607 thrombosis AE HPO: HP_0004419 SIDER: C0040053 a metabolic disorder AE that has an outcome of cell death. SS, YH 10057248 cell death AE GO: GO_0008219 SIDER: C0007587 a respiratory system AE which has an outcome of some respiratory tract neoplasm. YH 10029107 respiratory tract neoplasm AE competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A YH, AG, YL biochemical inhibitor role YH, AG, YL WEB: http://en.wikipedia.org/wiki/Agonist agonist role YH, AG, YL WEB: http://en.wikipedia.org/wiki/Receptor_antagonist In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors. antagonist role an inflammation AE that shows the result of an inflammation located in a vein, usually in the legs. YH, MW 10034879 phlebitis AE CTCAE:E13815 HPO: HP_0004419 NCIt:C38003 SIDER: C0031542 a liver, biliary, and pancreatic AE that has an outcome of pancreatitis. YH, MW 10033645 10033646 pancreatitis AE CTCAE: E10930 HPO: HP_0001733 NCIt: C3306 SIDER: C0030305 a cell death AE that has an outcome of apoptosis, a form of programmed cell death that occurs in multicellular organisms. SS, YH https://en.wikipedia.org/wiki/Apoptosis 10059512 apoptosis AE a cell death AE that has an outcome of necrosis SS, YH necrosis AE HPO: HP_0003713 SIDER: C0027540 A cardiovascular disorder AE that results in Insufficient blood supply for the need of a part of the body, usually as a result of a disease of the blood vessels supplying that part. SS, YH ischaemia AE 10061255 Note: also spelt ischemia. ischemia AE HPO: HP_0002597 SIDER: C0022116 an adverse event that occurs in hair, skin, or nail. hair, skin, and nail AE YH, SS, JX hair, skin or nail AE a hair, skin, and nail AE that occurs in hair. YH, SS hair AE a hair, skin, and nail AE that occurs in nail. YH, SS nail AE a metabolism, endocrine, and exocrine system AE that occurs in endocrine system. 10014698 YH, SS endocrine system AE a metabolism, endocrine, and exocrine system AE that occurs in exocrine system YH, SS exocrine system AE an adverse event that displays a congential and genetic disorder. congenital abnormality AE 10010331 YH, SS congenital AE a muscular weakness AE that shows weakness or inability to move a body part, often used to describe a neurologic condition. WEB: https://en.wikipedia.org/wiki/Paresis 局部麻痹 10033800 Neurologists use the term paresis to describe weakness, and plegia to describe paralysis in which all voluntary movement is lost. (Reference: https://en.wikipedia.org/wiki/Paresis) paresis AE HPO: HP_0008153 SIDER: C0030552 a syndrome AE that has an outcome of cystic fibrosis, an inherited disease that affects the lungs, digestive system, sweat glands, and male fertility. YH WEB: http://medical-dictionary.thefreedictionary.com/cystic+fibrosis 10011762 cystic fibrosis AE HPO: HP_0006552 SIDER: C0010674 a tumore AE that results in the outcome of hyperplasia, an abnormal increase in the number of normal cells in normal arrangement in an organ or tissue, which increases its volume. YH, SS hyperplasia AE HPO: HP_0010279 SIDER: C0020507 an adverse event that displays a disorder in abdomen. YH, SS abdominal AE an adverse event that results in genetic disorder. genetic disorder AE YH, SS genetic AE a liver, biliary, and pancreatic AE that has an outcome of hepatitis. YH hepatitis AE HPO: HP_0006562 SIDER: C0019158 an adverse event that displays an outcome of ulcer. YH, SS ulcer AE HPO: HP_0005229 SIDER: C0041582 a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body. WEB: http://medical-dictionary.thefreedictionary.com/fistula 10067143 YH, SS fistula AE HPO: HP_0010294 SIDER: C0016169 an abnormal fluid regulation AE which has an outcome of extravasation, a discharge or escape, as of blood, from a vessel into the tissues. YH, SS WEB: http://medical-dictionary.thefreedictionary.com/extravasation 10015866 extravasation AE an adverse event that displays an outcome of an sclerosis, the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue. YH, SS sclerosis AE a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient YH 10065283 inconsolable crying AE a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient YH unusual high-pitched crying AE a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient YH prolonged crying AE a decreased heart rate AE that results in a resting heart rate of under 60 beats per minutes (BPM). WEB: http://en.wikipedia.org/wiki/Bradycardia WEB: http://medical-dictionary.thefreedictionary.com/bradycardia 10006093 bradycardia AE HPO: HP_0001662 SIDER: C0428977 an adverse event that displays a disorder associated with child birth, newborn infant, or an infant. pregnancy, neonatal and perinatal disorder AE 10036585 YH, JX prenatal, perinatal or neonatal disorder AE an errored drug administration where a patient is administered with an ineffective drug YH administration of ineffective drug an errored drug administration where a patient is administered with an ctive drug with decreased effectiveness YH administration of drug with decreased effectiveness a bupropion-induced adverse event that is induced by aplenzin administration YH aplenzin-induced adverse event an errored drug administration where a patient is administered with a drug above the therapeutic level YH drug overdose administration an errored drug administration where a patient is administered with an drug without knowing the dose used. YH administration of drug with omitted dose a quality that represents resistance of a patient to a drug. YH drug resistance an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site). YH application site reaction 10003055 medical intervention site AE a site that is used for a medical intervention YH medical intervention site an errored drug administration where a patient is administered with an drug stored in capsule with physical defect YH administration of drug stored in capsule with physical defect an errored drug administration where a patient is administered with an drug with wrong technique YH 10064353 administration of drug with wrong technique a drug administration where a patient is administered with an drug with incorrect route YH 10064304 administration of drug with incorrect route A pregnancy, neonatal and perinatal AE that displays a disorder associated with newborn infant or an infant. YH neonatal AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with childbirth YH perinatal AE a medical intervention that has an errored medication YH 10027091 errored medication a medical intervention that has errored drug medication SS, YH 10064355 errored drug administration a therapeutic intervention that uses radiation YH radiotherapy a vascular disorder AE that affects the artery SS arterial disease AE arterial disorder AE HPO: HP_0002620 SIDER: C0852949 an artery disorder AE that is characterized by a narrowing of the blood vessels outside of the heart. SS peripheral artery disease AE peripheral artery disorder AE WEB: http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=peripheral+arterial+disease 10067825 peripheral arterial disease AE HPO: HP_0004950 SIDER: C1704436 an autoimmune disease AE that shows a symptom of dry red patches on the skin. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/psoriasis WEB: https://en.wikipedia.org/wiki/Psoriasis 10037153 psoriasis AE HPO: HP_0003765 SIDER: C0033860 a distal sensory neuropathy AE characterized by an increase in degree (cumulative) AG, YH cumulative distal sensory neuropathy AE a behavior and neurological AE that has an outcome of stress in a patient YH stress AE an abscess AE that has an outcome of a pocket of infected fluid and pus located inside the abdominal cavity DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000212.htm 10060921 abdominal abscess AE a discomfort AE that has an outcome of a stomach ache DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Abdominal+discomfort 10000059 abdominal discomfort AE HPO: HP_0002027 SIDER: C0232487 a sensory capability AE that results in a sensation of elevated abdominal pressure and volume DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0003609/ 10000060 abdominal distension AE CTCAE: E10456 HPO: HP_0003270 NCIt: C78161 SIDER: C0000731 a sepsis AE that has an outcome of sepsis in the abdominal area DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001687/ 10058040 abdominal sepsis AE an abdominal abscess AE that has an outcome of a collection of pus in the abdominal wall, causes inflammation DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002329/ 10000099 abdominal wall abscess AE a behavioral AE that results in uncharacteristic behaviors 12/19/2015: This term became obsolete since its meaning can be quite confusing. "behavior AE" is now considered as the synonym of 'behavioral and neurological AE'. DJ, SS, YH abnormal behavior AE abnormal behaviour AE behavioral AE 10061422 obsolete: behavior AE HPO: HP_0000708 SIDER: C0233514 a behavioral and neurological AE that results in odd dreams DJ, SS, YH 10000125 abnormal dreams AE an abortion AE that has an outcome of expulsion of a fetus from the uterus brought on intentionally by medication or instrumentation DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/induced+abortion 10000220 abortion induced AE an abortion AE that results in a miscarriage DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002458/ 10000234 abortion spontaneous AE HPO: HP_0005268 SIDER: C0000786 a skin AE that is characterized by pimples generally on the face, chest and back, caused by clogging of the pores DJ, SS, YH acne vulgaris AE WEB: http://medical-dictionary.thefreedictionary.com/acne 10000496 acne AE HPO: HP_0001061 SIDER: C0702166 a immune system disorder AE that is caused by the HIV virus DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/hivaids.html 10000565 acquired immunodeficiency syndrome AE HPO: HP_0002721 SIDER: C0001175 a hematopoietic system AE that has an outcome of a prolonged time taken for blood to clot. The partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. PTT measures the efficacy of the comon coagulation pathways and helps tell if bleeding or clotting problems exist. DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm 10000636 activated partial thromboplastin time prolonged AE CTCAE: E12073 HPO: HP_0003645 NCIt: C27028 SIDER: C0853223 a digestive system AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the intestine attack the transplant recipient's body DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm 10066264 acute graft versus host disease in intestine AE a skin AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the skin attack the transplant recipient's body DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm 10066262 acute graft versus host disease in skin AE a hematopoietic system AE that has an outcome of a type of acute leukemia, characterized by anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, and bone pain DJ, SS, YH acute lymphocytic leukaemia AE WEB: http://medical-dictionary.thefreedictionary.com/Blast+count 10000846 acute lymphocytic leukemia AE HPO: HP_0006721 SIDER: C0023449 a hematopoietic system AE that has an outcome of the reoccurance of fast-growing cancer of the white blood cells where abnormal blasts do not fight infections after a period of remission DJ, SS, YH acute lymphocytic leukaemia recurrent AE WEB: http://marrow.org/Patient/Disease_and_Treatment/About_Your_Disease/ALL/Acute_Lymphoblastic_Leukemia_(ALL).aspx 10063620 acute lymphocytic leukemia recurrent AE a hematopoietic system AE that has an outcome of cancer in the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells DJ, SS, YH acute myeloid leukaemia AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/ 10000880 acute myeloid leukemia AE HPO: HP_0004808 SIDER: C0023467 an acute myeloid leukemia AE that shows an recurrence of acute myeloid leukemia DJ, SS, YH acute myeloid leukaemia recurrent AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/ 10059034 acute myeloid leukemia recurrent AE a lung disorder AE that has the outcome fluid accumulation in the air spaces and parenchyma of the lungs with rapid onset DJ, SS, YH acute pulmonary oedema AE WEB: http://medical-dictionary.thefreedictionary.com/Acute+pulmonary+edema 10001029 acute pulmonary edema AE HPO: HP_0100598 SIDER: C0155919 a respiratory distress AE that prevents enough oxygen from getting to the lungs and into the blood DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001164/ 10001052 acute respiratory distress syndrome AE HPO: HP_0002093 SIDER: C0035222 a lung disorder AE that has an outcome of a condition in which not enough oxygen passes from the lungs into the blood, with rapid onset DJ, SS, YH, MW WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/rf/ 10001053 acute respiratory failure AE HPO: HP_0002093 SIDER: C0264490 a syncope AE that results in sudden episodes of fainting and sometimes seizures DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518479/ 10001115 adams-stokes syndrome AE a reproductive system AE that results in the thickening of the walls of the uterus. This ccurs when endometrial tissue, which normally lines the uterus, moves into the outer muscular walls of the uterus. DJ, SS, YH endrometriosis interma AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002481/ 10056268 adenomyosis AE a viral infection that occurs in the respiratory system and has an outcome of viral infection by nonenveloped icosahedral viruses causing illness in the respiratory system DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Adenovirus+Infections 10060931 adenovirus infection AE HPO: HP_0004429 SIDER: C0001486 a tumor AE that results in an abnormal number of cells proliferating on the kidney(s) DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22486993 10061588 adrenal neoplasm AE an endocrine system AE that results in the suppression of the functions of the adrenal glands DJ, SS, YH 10001382 adrenal suppression AE a behavior and neurological AE that results in an increase in hostile behavior DJ, SS, YH 10001488 aggression AE HPO: HP_0000718 SIDER: C0001807 a hematopoietic system AE that has an outcome of acute leukopenia, or lowered white blood cell count, most commonly of neutrophils causing neutropenia in circulating blood JX, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001295.htm 粒性白血球缺乏症 10001507 agranulocytosis AE HPO: HP_0001913 SIDER: C0001824 an embolism AE that is caused by an air bubble in the vessel DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23295634 10001526 air embolism AE a liver related investigation result abnormal AE that has an outcome of an abnormal blood level of alanine aminotransferase DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 10001547 alanine aminotransferase level abnormal AE an alanine aminotransferase level abnormal AE that has an outcome of a decrease in alanine aminotransferase level in body DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 10001549 alanine aminotransferase level decreased AE an alanine aminotransferase level abnormal AE that has an outcome of elevated levels of alanine transaminase, an enzyme most commonly found in the liver DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 10001551 alanine aminotransferase level increased AE CTCAE: E12077 NCIt: C26948 a liver/biliary system AE that is characterized by liver disease caused by the patient's alcoholic activity DJ, SS, YH 10001627 alcoholic liver disease AE a behavior and neurological AE that has an outcome of significantly different waking beta wave state DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/20182997 10001854 altered state of consciousness AE a female reproductive system AE that is characterized by the absence of menstrual period in a woman of reproductive age DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21942684 10001928 amenorrhoea AE HPO: HP_0000141 SIDER: C0002453 an abnormal fluid regulation AE that results in a decreased volume of amniotic fluid during pregnancy DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22039031 10063356 amniotic fluid volume decreased AE an anus AE that has an outcome of a split or tear in the mucosa lining the lower rectum DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002116/ 10002153 anal fissure AE HPO: HP_0004378 SIDER: C0016167 an ulcer AE that has an outcome of an ulcer in the anal cavity DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/17073250 10002180 anal ulcer AE CTCAE: E10496 NCIt: C79536 a vascular disorder AE that has an outcome of a leakage at the site of the intersection of two blood vessels DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23122582 10050456 anastomotic leak AE a cardiac disorder AE that is stable and shows the symptom of a chest pain due to ischemia of the heart DJ, SS, YH stable angina AE WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Angina-Pectoris-Stable-Angina_UCM_437515_Article.jsp# WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723 10002383 angina pectoris AE HPO: HP_0001681 SIDER: C0002962 a angina AE that is unstable and has an outcome of a condition in which the heart doesn't get enough blood flow through the blood vessels of the heart muscle, may lead to heart attack. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001250/ 10002388 angina unstable AE HPO: HP_0001681 SIDER: C0002965 an immunology and allergy investigation result abnormal AE that is characterized by antibodies present that are against cell-membrane phospholipids that provoke blood clots DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23231732 10048678 antiphospholipid antibodies positive AE a urinary system AE that has an outcome of the absence of urine formation DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/anuria 10002847 anuria AE HPO: HP_0100519 SIDER: C0003460 a vascular disorder AE that results in a condition affecting the aorta and aortic valves DJ, SS, YH WEB: http://www.rightdiagnosis.com/medical/aorta_disorder.htm 10058648 aortic disorder AE HPO: HP_0001679 SIDER: C0003493 a cardiac valve disease AE that has an outcome of inability of the aortic valve to function effectively DJ, SS, YH WEB: http://www.rightdiagnosis.com/a/aortic_valve_incompetence/intro.htm 10002915 aortic valve incompetence AE HPO: HP_0001659 SIDER: C0003504 a congenital abnormality AE with an outcome of defective development or congenital absense of an organ or tissue DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/737831 10002961 aplasia AE HPO: HP_0010515 SIDER: C0243065 Aplastic anaemia AE is an anemia AE that occurs when the bone marrow, and the blood stem cells that reside there are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). DJ, SS, JX, YH aplastic anemia WEB: http://www.ncbi.nlm.nih.gov/pubmed/23292240 再生障碍性贫血 10002967 aplastic anaemia AE HPO: HP_0001915 SIDER: C0002874 a serious AE that is due to an allergic brochospasm, which causes a serious problem with breathing and requires treatment in an emergency room. YH, JX URL: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm URL: https://en.wikipedia.org/wiki/Bronchospasm allergic brochospasm AE that requires treatment in emergency a hypersensitivity AE that occurs at the site of an application of a medical intervention (e.g., drug administration or vaccination). DJ, SS, YH 10063683 application site hypersensitivity AE an infection AE that occurs at the site of drug application DJ, SS, YH 10049041 application site infection AE a hemorrhage AE that has an outcome of bleeding in the arteries DJ, SS, YH arterial bleeding AE arterial haemorrhage AE 10060964 arterial hemorrhage AE CSF protein increased AE is an abnormal cerebrospinal fluid production that results in and increase in blood level CSF protein SS, YH 10011575 CSF protein increased AE a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of an abnormal result in the cerebrospinal fluid (CSF) collection test that examines the fluid that surrounds the brain and spinal cord This should be inferred as a "AE: lab test abnormal". SS, YH, EB WEB: www.nlm.nih.gov/medlineplus/ency/article/003428.htm 10059703 CSF test result abnormal AE Henoch-Schonlein purpura AE is a purpura AE, a systemic vasculitis (inflammation of blood vessels) characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney. This results from some allergic response, SS, YH allergic purpura, anaphylactoid purpura, vascular purpura WEB: http://en.wikipedia.org/wiki/Henoch-Schonlein_purpura 10019617 Henoch-Schonlein purpura AE HPO: HP_0000979 SIDER: C0034152 SS, YH WEB: http://en.wikipedia.org/wiki/Abasia 10049460 a movement disorder AE that has an outcome of abasia, a movement disorder that results in and inability to walk due to impaired muscle coordination abasia AE HPO: HP_0002540 SIDER: C0877217 a stomach pain AE that is observed in upper stomach SS, YH 10000087 abdominal pain upper AE HPO: HP_0002027 SIDER: C0232492 a behavior and neurological AE that has an outcome of loss of taste functions of the tongue, particularly the inability to detect sweetness, sourness, bitterness, saltiness, and umami (the taste of monosodium glutamate). SS, YH WEB: http://en.wikipedia.org/wiki/Ageusia 10001480 ageusia AE a sensory neuropathy AE that has an outcome of chronic sensory neuropathy characterized by being persistent or long-lasting in nature AG, YH chronic sensory neuropathy AE a behavior and neurological AE that has an outcome of a lack of functioning olfaction, an inability to perceive odors SS, YH WEB: http://en.wikipedia.org/wiki/Olfaction 10002653 anosmia AE HPO: HP_0010632 SIDER: C0003126 a psychiatric disorder AE that has an outcome of a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry. SS, YH WEB: http://en.wikipedia.org/wiki/Anxiety 10002855 anxiety AE CTCAE: E12883 HPO: HP_0000739 NCIt: C26696 SIDER: C0003467 an arrhythmia AE that is characterized by rapid regular atrial contractions occurring usually at rates between 250 and 400 per minute and often producing saw-tooth waves in an electrocardiogram. SS AF auricular flutter WEB: http://medical-dictionary.thefreedictionary.com/atrial+flutter 10003662 atrial flutter AE CTCAE: E10087 HPO: HP_0004749 NCIt: C51224 SIDER: C0004239 a behavior and neurological AE that has an outcome of a disturbance that causes an individual to feel unsteady, giddy, woozy, or have a sensation of movement, spinning, or floating. SS, YH WEB: http://en.wikipedia.org/wiki/Balance_disorder 10049848 balance disorder AE HPO: HP_0002141 SIDER: C0575090 blister AE is a skin adverse event that results in a small pocket of fluid within the upper layers of the skin SS, YH WEB: http://en.wikipedia.org/wiki/Blister 10005191 blister AE HPO: HP_0008066 SIDER: C0005758 cellulitis AE is an inflammation AE that is a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin SS, YH WEB: http://en.wikipedia.org/wiki/Cellulitis 10007882 cellulitis AE HPO: HP_0003553 SIDER: C0007642 a behavior and neurological AE that has an outcome of a type of perspiration usually associated with anxiety or fear SS, YH WEB: http://en.wikipedia.org/wiki/Cold_sweat cold sweat AE convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body SS, YH WEB: http://en.wikipedia.org/wiki/Convulsion 10010904 convulsion AE HPO: HP_0001250 SIDER: C0009951 SS, YH a movement disorder AE that has an outcome of difficulty in walking properly difficulty in walking AE a behavior and neurological AE that has an outcome of distortion of the sense of taste SS, YH, MW WEB: http://en.wikipedia.org/wiki/Dysgeusia 10013911 dysgeusia AE CTCAE:E12643 HPO: HP_0000223 NCIt:C28145 SIDER: C0013378 a movement disorder AE that has an outcome of dyskinesia SS, YH WEB: http://en.wikipedia.org/wiki/Dyskinesia 10013916 dyskinesia is a movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements dyskinesia AE HPO: HP_0100660 SIDER: C0013384 An abnormal respiration AE that is characterized by a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity. MedDRA: 10013968 is for "dyspnoea"; MedDRA: 10013963 is for "dyspnea". SS, YH air hunger dyspnoea shortness of breath WEB: http://en.wikipedia.org/wiki/Dyspnoea https://en.wikipedia.org/wiki/Shortness_of_breath https://www.mayoclinic.org/symptoms/shortness-of-breath/basics/definition/sym-20050890 呼吸困难 10013963 10013968 dyspnea AE CTCAE: E13368 HPO: HP_0002094 NCIt: C2998 SIDER: C0013404 UMLS CUI: C0013404 SS, YH, EB WEB: http://en.wikipedia.org/wiki/Electromyography 10014431 a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of abnormal activity in skeletal muscles evaluted and measured by electromyography electromyogram result abnormal AE eye irritation AE is an eye disorder AE that results in mild eye redness, itching, or tearing SS, YH WEB: http://www.freemd.com/eye-irritation/ 10015946 eye irritation AE HPO: HP_0000478 SIDER: C0235266 eye pruritus AE is a pruritus AE (an unpleasant sensation that evokes the desire or reflex to scratch) at the eye area SS, YH 10052140 eye pruritus AE HPO: HP_0000989 SIDER: C0022281 glomerulonephritis AE is a kidney disorder AE that results in a renal disease that is characterized by inflammation of the glomeruli, or small blood vessels in the kidneys. SS, YH glomerular nephritis AE WEB: http://en.wikipedia.org/wiki/Glomerulonephritis glomerulonephritis AE HPO: HP_0000099 SIDER: C0017658 A conduction system disorder AE that is a condition in which the electrical impulse from the bundle of His to the ventricles is delayed or fails to conduct along the right bundle branch, resulting in right ventricular depolarization by cell-to-cell conduction spreading from the interventricular septum and left ventricle to the right ventricle–ie, slow and uncoordinated Natural history Surgically induced RBBB has few acute hemodynamic consequences and a generally benign course long term; rarely, progression to complete heart block and sudden death occur, especially if accompanied by major His-Purkinje system–eg, left anterior hemiblock, first-degree AV block–injury; tetralogy of Fallot repair with an RBBB and a markedly prolonged QRS duration >180 ms have an ↑ risk for ventricular arrhythmias and sudden death. SS RBBB right bundle branch block WEB: http://medical-dictionary.thefreedictionary.com/right+bundle+branch+block 10006582 bundle branch block right AE HPO: HP_0011712 SIDER: C0085615 a cardiac disorder AE of the electrical conduction system that controls the heart rate, generates and conducts electrical impulses throughout the muscle of the heart, stimulating the heart to contract and pump blood. SS cardiac conduction disorder AE conduction disorder AE WEB: http://www.medterms.com/script/main/art.asp?articlekey=8407 10000032 10010276 conduction system disorder AE CTCAE: E10114 NCIt: C78245 a sensory capability AE that has an outcome of hypoaesthesia, meaning that skin loses some of its sensitivity to pain or touch SS, YH disesthesia AE hypoaesthesia AE WEB:http://medguides.medicines.org.uk/document.aspx?name=hypoaesthesia 10020937 hypoesthesia AE HPO: HP_0010830 SIDER: C0020580 a thrombosis AE that has an outcome of a blood clot within an artery [SS] Per DRA and KKB's comment, arterial thrombosis may also be characterized as an embolism. DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23236330 10003178 arterial thrombosis AE HPO: HP_0004420 SIDER: C0151942 a viral infection AE that demonstrates an influenza viral infection. Influenza is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals SS, YH WEB: http://en.wikipedia.org/wiki/Influenza influenza AE HPO: HP_0005376 MDR: 10022000 SIDER: C0021400 a coronary artery disease AE with the outcome hardening of the coronary artery due to a build up of waxy plaque on the inside of blood vessels DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Coronary+Arteriosclerosis 10003211 arteriosclerosis coronary artery AE HPO: HP_0004929 SIDER: C0010054 injected limb mobility decreased AE is a mobility decreased AE that occurs in the limb in which injection is administered SS, YH injected limb mobility decreased AE a haematoma AE that has an outcome of injection-site haematoma, which results in a collection of blood outside the blood vessels at the physical area of injection SS, YH injection-site haematoma AE WEB: http://medical-dictionary.thefreedictionary.com/hematoma http://en.wikipedia.org/wiki/Hematoma 10022066 injection-site hematoma AE injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site SS, YH WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration injection-site induration AE injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection SS, YH WEB: http://en.wikipedia.org/wiki/Itch WEB: http://medical-dictionary.thefreedictionary.com/pruritus 10022093 injection-site pruritus AE injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site SS, YH WEB: http://en.wikipedia.org/wiki/Rash injection-site rash AE injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site SS, YH injection-site warmth AE A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm 10023232 joint swelling AE HPO: HP_0005833 SIDER: C0152031 an adverse event that occurs in kidney. SS, YH, DA abnormal renal function AE renal disorder AE https://medlineplus.gov/ency/article/001265.htm 10038428 kidney AE a behavior and neurological AE that has an outcome of an increase in production, secretion, and shedding of tears SS, YH WEB: http://en.wikipedia.org/wiki/Tears WEB: http://www.medterms.com/script/main/art.asp?articlekey=6199 10023644 lacrimation increased AE HPO: HP_0009926 SIDER: C0152227 lip swelling AE is an edema (swelling) AE that results in enlargement or protuberance in the lip SS, YH WEB: http://en.wikipedia.org/wiki/Swelling_%28medical%29 10024570 lip swelling AE HPO: HP_0000159 SIDER: C0240211 A lymphadenopathy AE that results in swollen/enlarged lymph nodes SS, YH WEB: http://en.wikipedia.org/wiki/Lymphadenopathy lymphadenitis AE HPO: HP_0002840 SIDER: C0024205 mobility decreased AE is a nervous system AE that results in difficulty in movement leading to less ability to move part(s) of body SS, YH 10048334 mobility decreased AE HPO: HP_0006217 SIDER: C0700572 a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength). SS, YH WEB: http://en.wikipedia.org/wiki/Muscular_weakness 10028372 muscular weakness AE HPO: HP_0001324 SIDER: C0151786 a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton SS, YH 10052904 musculoskeletal stiffness AE HPO: HP_0003552 SIDER: C0948525 nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels SS, YH WEB: http://en.wikipedia.org/wiki/Nasal_congestion 10028735 nasal congestion AE CTCAE: E13450 HPO: HP_0001742 NCIt: C78500 SIDER: C0027424 a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system SS, YH common cold AE WEB: http://en.wikipedia.org/wiki/Nasopharyngitis nasopharyngitis AE HPO: HP_0002087 SIDER: C0027441 an neuropathy AE that results in a damage to the peripheral nervous system (PNS, outside the brain and spinal cord), the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body. SS, YH neuropathy peripheral AE WEB: http://en.wikipedia.org/wiki/Peripheral_neuropathy WEB: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm 10029331 peripheral neuropathy AE ocular hyperaemia AE is an eye disorder AE that results in severe redness and irritation of the eyes SS, YH ocular hyperaemia AE WEB: http://www.med.miami.edu/news/view.asp?id=259 10030041 ocular hyperemia AE a pain AE that has an outcome of oropharyngeal pain SS, YH WEB: http://en.wikipedia.org/wiki/Oropharyngeal_airway 10068319 oropharyngeal pain is a pain in oral airway oropharyngeal pain AE HPO: HP_0010833 SIDER: C2363731 an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection SS, YH WEB: http://en.wikipedia.org/wiki/Otitis_media 10033078 otitis media AE CTCAE: E11477 HPO: HP_0008623 NCIt: C34885 SIDER: C0029882 an inflammation AE that has an outcome of pericaditis, which is a cardiovascular disorder that results in a condition in which the sac-like covering around the heart (pericardium) becomes inflamed SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000182.htm 10034484 pericarditis AE CTCAE: E10180 HPO: HP_0001701 NCIt: C34915 SIDER: C0031046 pharyngeal edema AE is an edema AE that results in an bbnormal fluid accumulation in TISSUES or body cavities in pharynx (throat swelling). SS, YH pharyngeal oedema AE WEB: http://www.ncbi.nlm.nih.gov/mesh/68004487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Mesh.Mesh_ResultsPanel.Mesh_RVDocSum pharyngeal edema AE pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx SS, YH WEB: http://en.wikipedia.org/wiki/Pharyngitis 10034835 pharyngitis AE CTCAE: E11525 HPO: HP_0100776 NCIt: C26851 SIDER: C0031350 a pain AE that shows a pain in sinus and throat SS, YH, MW WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/ 10034844 pharyngolaryngeal pain AE CTCAE: E13482 HPO: HP_0010833 NCIt: C78556 SIDER: C0858635 rash macular AE is a rash AE that results in a skin eruption in which the lesions are flat and less than 1 cm in diameter SS, YH rash macular AE WEB: http://medical-dictionary.thefreedictionary.com/macular+rash macular rash AE HPO: HP_0000988 SIDER: C0221201 a rash AE that shows clustered papules, i.e., small, round, raised bumps that have clear borders. SS, YH rash papular AE WEB: http://en.wikipedia.org/wiki/Rash WEB: http://www.healthline.com/symptom/papule WEB: http://www.rightdiagnosis.com/sym/papular_rash.htm 10037876 papular rash AE HPO: HP_0007432 SIDER: C0221202 A respiratory system AE thta is characterized by inflammation of the lung parenchyma leading to impaired gas exchange with concomitant systemic release of inflammatory mediators causing inflammation, hypoxemia and frequently resulting in multiple organ failure. SS, YH WEB: http://en.wikipedia.org/wiki/Acute_respiratory_distress_syndrome 10038687 respiratory distress AE HPO: HP_0002747 SIDER: C0476273 respiratory tract congestion AE is a respiratory system AE that results in congestion in respiratory tract SS, YH respiratory tract congestion AE retching AE is a digestive system AE that results in a process in the human body where gastric (and sometimes duodenal) contents are forced into the esophagus, but do not enter the pharynx SS, YH WEB: http://en.wikipedia.org/wiki/Retching 10038776 retching AE rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose SS, YH runny nose WEB: http://en.wikipedia.org/wiki/Rhinitis WEB: http://medical-dictionary.thefreedictionary.com/rhinitis 10028116 rhinitis AE HPO: HP_0002257 SIDER: C0035455 rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid SS, YH rhinorrhoea AE WEB: http://en.wikipedia.org/wiki/Rhinorrhoea rhinorrhea AE a pain AE that occurs in shoulder shoulder pain is a pain iin or around the shoulder joint SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003171.htm shoulder pain AE sinus congestion AE is a nasal congestion AE that results in blockage of the air cavities in the cranial bones or nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels SS, YH WEB: http://en.wikipedia.org/wiki/Sinus_%28anatomy%29, http://en.wikipedia.org/wiki/Nasal_congestion sinus congestion AE HPO: HP_0002257 SIDER: C0152029 sneezing AE is a respiratory system adverse event that results in sternutation, a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa SS, YH, MW sternutation WEB: http://en.wikipedia.org/wiki/Sneezing 10041232 sneezing AE CTCAE:E13572 NCIt:C50746 an increased heart rate AE where the heart rate exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual) SS, YH WEB: http://en.wikipedia.org/wiki/Tachycardia 10043071 tachycardia AE HPO: HP_0001649 SIDER: C0039231 a tendon disorder AE that has an outcome of tendonitis SS, YH tendinitis AE WEB: http://en.wikipedia.org/wiki/Tendinitis tendonitis is a tendon disorder that results in an inflammation of a tendon tendonitis AE HPO: HP_0100261 SIDER: C0039503 a sensory capability AE that has an outcome of a sensation of tightness in the throat 10043528 throat tightness AE an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx SS, YH URI, URTI WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection 10046300 upper respiratory tract infection AE CTCAE: E11604 HPO: HP_0002788 NCIt: C35650 SIDER: C0041912 a viral infection AE that results in an acute contagious diseased caused by herpes varicella zoster virus; causes a rash of vesicles on the face and body. SS, YH chicken pox AE varicella zoster virus infection AE WEB: http://wordnetweb.princeton.edu/perl/webwn?s=varicella varicella AE HPO: HP_0005428 SIDER: C0008049 a paresthesia AE that occurs in oral area. SS, YH paraesthesia oral AE http://www.answers.com/topic/oral-paresthesia 10057372 paraesthesia oral is a paresthesia that results in a numbness or tingling that occurs in the mucosa or tissues of the oral cavity. paresthesia oral AE HPO: HP_0003401 SIDER: C0521591 an abnormal body temperature AE which has an outcome of fever YH, SS, MW body temperature increased AE febrile response pyrexia AE Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. WEB: http://en.wikipedia.org/wiki/Pyrexia 10005911 10016558 10037660 Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °F). fever AE CTCAE: E11102 NCIt: C3038 a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. YH URL: http://en.wikipedia.org/wiki/Rash URL: http://www.webmd.com/skin-problems-and-treatments/guide/common-rashes Wick JY. Drug-induced rash: nuisance or threat? Consult Pharm. 2013 Mar;28(3):160-6. PMID: 23462025. 10037844 Drug-induced rash is the most commonly reported drug reaction. rash AE HPO: HP_0000988 SIDER: C0015230 an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite. change of name from 'infection adverse event' to 'infectious adverse event' on 09/23/13 for a better clinical relevance, move 'infection adverse event' as an alternative term - SS YH, JX infectious adverse event WEB: http://medical-dictionary.thefreedictionary.com/infection infection 10021789 infection AE An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. YH syndrome AE a psychiatric disorder AE that has an outcome of emotional state of excitement or restlessness YH, MW 10001497 agitation AE CTCAE:E12874 HPO: HP_0000711 NCIt:C79530 SIDER: C0085631 injection-site AE is an AE that occurs in an injection site (e.g., during vaccination). YH, JX, SS injection site AE injection-site adverse event injection-site reaction local reaction AE 10022095 injection-site AE CTCAE: E11138 NCIt: C3508 a hypersensitivity AE which has an outcome of injection-site hypersensitivity YH injection-site hypersensitivity AE an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found. YH, RR injection-site oedema AE injection-site swelling AE WEB: http://www.uptodate.com/contents/edema-swelling-beyond-the-basics 10053425 injection-site edema AE a pain AE that occurs in an injection site of a medical intervention YH 10022086 injection-site pain AE an inflammation AE which has an outcome of injection-site inflammation YH injection-site inflammation AE a hemorrhage AE that has an outcome of injection-site hemorrhage YH 10022067 injection-site hemorrhage AE a tumor or mass AE that occurs in an injection-site YH, SS injection site nodule AE injection-site mass is a mass at physical injection site injection-site mass AE a skin adverse event that has an outcome of pruritus YH, SS, MW itch itching pruritus generalised AE WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity 10037087 Pruritus is an itch (Latin: pruritus), i.e., an unpleasant sensation that evokes the desire or reflex to scratch. pruritus AE CTCAE:E13686 HPO: HP_0000989 NCIt:C3344 SIDER: C0033774 a sensory capability AE that has an outcome of pain in a patient YH, MW 10033371 pain AE CTCAE: E11167 HPO: HP_0010833 NCIt: C3303 SIDER: C0030193 a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders. YH, MW muscle pain AE 10028411 myalgia AE CTCAE:E12485 HPO: HP_0003326 NCIt:C27009 SIDER: C0231528 Urticaria AE is a rash AE notable for dark red, raised, itchy bumps. YH, MW hives 10046735 urticaria AE CTCAE:E13746 HPO: HP_0001025 NCIt:C3432 SIDER: C0042109 a pain AE that has an outcome of headache YH, MW 10019211 headache AE CTCAE: E12678 HPO: HP_0002315 NCIt: C34661 SIDER: C0018681 an AE that occurs in respiratory system. I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He YH respiratory system AE a leukocyte cell number abnormal AE that has an outcome of greater than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). SS, YH, EB increased leukocyte cell number AE leukocytosis AE white blood cell count increased AE WEB: http://en.wikipedia.org/wiki/Leukocytosis 10024378 10047943 leukocyte cell number increased AE CTCAE: E10048 MP: MP_0000218 NCIt: C35524 a leukocyte cell number abnormal AE that has an outcome of reduction in the number of leukocytes, or of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). decreased leukocyte cell number AE white blood cell count decreased AE 10047942 leukocyte cell number decreased AE CTCAE: E12232 MP: MP_0000221 NCIt: C26816 a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries abnormal blood pressure AE MP: MP_0000230 a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength. YH 10003549 asthenia AE HPO: HP_0001324 SIDER: C0004093 a muscle pain AE that has an outcome of muscle ache. YH muscle ache AE A rash AE that shows a flat, red area on the skin overed with small confluent bumps. YH, MW maculopapular rash AE rash maculo-papular AE rash maculopapular AE WEB: http://en.wikipedia.org/wiki/Maculopapular_rash 10037868 The term "maculopapular" is a compound: macules are small, flat discolored spots on the surface of the skin; and papules are small, raised bumps. maculo-papular rash AE CTCAE:E13700 NCIt:C75579 An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. YH, MW 10003239 arthralgia AE CTCAE:E12374 HPO: HP_0002829 NCIt:C50464 SIDER: C0003862 vesiculobullous rash AE is a rash AE characterized by serous-fluid-filled vesicles (blisters) YH vesiculobullous rash AE HPO: HP_0000988 SIDER: C0151883 a syndrome AE which has an outcome of screaming syndrome YH screaming syndrome AE a sensory capability AE that has an outcome of dizziness YH, SS, MW 10013573 Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. dizziness AE CTCAE:E12631 HPO: HP_0002321 NCIt:C37943 SIDER: C0012833 peripheral edema AE is an edema AE that results in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids YH, SS edema peripheral AE oedema peripheral AE peripheral edema AE WEB: http://en.wikipedia.org/wiki/Peripheral_edema 10030124 10050068 edema limbs AE CTCAE: E11086 NCIt: C78262 a sensory capability AE that has an outcome of malaise YH 10025482 Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. malaise AE CTCAE: E11152 HPO: HP_0002321 NCIt: C3832 SIDER: C0231218 a behavior and neurological AE that has an outcome of somnolence YH, SS, MW drowsiness 10041349 Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). somnolence AE CTCAE:E12814 HPO: HP_0001262 NCIt:C26754 SIDER: C2830004 a sensory neuropathy AE that shows a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect. YH, MW paraesthesia AE WEB: http://en.wikipedia.org/wiki/Paraesthesia 10033775 10033987 Paresthesia is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic. paresthesia AE CTCAE: E12758 NCIt: C28177 a behavior and neurological AE that has an outcome of abnormal crying in a patient YH 10011469 crying abnormal AE a sensory capability AE that has an outcome of chills YH feeling cold AE 10008531 Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. chills AE CTCAE: E11074 HPO: HP_0001945 NCIt: C35143 SIDER: C0085593 a behavior and neurological AE that has an outcome of stupor YH 10042264 Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization. stupor AE HPO: HP_0004372 SIDER: C0085628 a gustatory system AE which demonstrates a decreased sensation of appetite. YH, MW anorexia nervosa AE decreased appetite AE WEB: http://www.mayoclinic.org/diseases-conditions/anorexia/basics/definition/con-20033002 厌食症 10002646 10002649 10061428 anorexia AE CTCAE: E12252 HPO: HP_0002039 NCIt: C2875 SIDER: C0003123 face edema AE is an edema AE that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms YH, SS, MW emema face AE face oedema AE oedema face AE WEB:http://www.nlm.nih.gov/medlineplus/ency/article/003105.htm swelling face 10014222 10016029 10042682 face edema AE CTCAE: E11082 NCIt: C78289 an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear YH, SS, MW coughing AE WEB: http://medical-dictionary.thefreedictionary.com/cough WEB: http://www.nlm.nih.gov/medlineplus/cough.html cough 10011224 cough AE CTCAE:E13364 NCIt:C37935 a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention. YH flu-like symptom AE flu syndrome AE CTCAE: E11108 NCIt: C78302 a sensory capability AE that has an outcome of loss of consciousness, fainting YH, SS, MW Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. fainting WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29 WEB: http://en.wikipedia.org/wiki/Unconsciousness 10024855 10042772 syncope AE CTCAE: E12832 HPO: HP_0001279 NCIt: C35053 SIDER: C0039070 a skin adverse event that has an outcome of sweating According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH sweating AE HPO: HP_0000975 SIDER: C0038990 According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH, SS WEB: http://en.wikipedia.org/wiki/Abdominal_pain 10000081 a pain AE that is observed in abdominal cavity abdominal pain AE HPO: HP_0002027 SIDER: C0000737 an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states YH, SS, MW blood pressure increased WEB: http://www.ncbi.nlm.nih.gov/pubmed/21722707 10005750 10020772 hypertension AE CTCAE: E13785 HPO: HP_0000822 MP: MP_0000231 NCIt: C3117 SIDER: C0020538 a cardiac valve disease AE that is characterized by a condition of the heart in which the aortic valve, located between the aorta and left ventricle of the heart, is norrower than normal size SS WEB: http://medical-dictionary.thefreedictionary.com/aortic+valve+stenosis 10002918 aortic valve stenosis AE HPO: HP_0005173 SIDER: C0003507 a muscular weakness AE that has an outcome of myasthenia. Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. YH, SS myasthenia gravis myasthenia syndrome AE myasthenic syndrome AE myasthenia AE HPO: HP_0001324 SIDER: C0947912 a pain AE that occurs at the chest According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). YH 10008479 chest pain AE HPO: HP_0001681 SIDER: C0008031 a sensory neuropathy AE which has an outcome of sensory axonal characterized by damage to axonas of the peripheral nervous system (PNS) AG, YH sensory axonal AE an abnormal vision AE characterised by leakage of fluid under the retina causing visual impairment, usually in one eye. SJ, YH central serous chorioretinopathy WEB: http://en.wikipedia.org/wiki/Central_serous_retinopathy 10063118 central serous retinopathy AE a movement disorder AE that has an outcome of twitching, an involuntary sudden movement of part of the body. According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). YH twitching AE a seizure AE that has an outcome of a seizure disorder associated with an elevated temperature YH, BY http://emedicine.medscape.com/article/1176205-overview febrile seizure AE a respiratory system AE which has an outcome of asthma YH 哮喘 10003553 Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation. asthma AE HPO: HP_0002099 SIDER: C0004096 a pain AE that has an outcome of neck pain According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10028836 neck pain AE CTCAE: E12493 HPO: HP_0003418 NCIt: C50663 SIDER: C0007859 an arthritis AE that has an outcome of inflammation of a joint, resulting from infectious agents, such as bacteria and viruses DJ, SS, YH WEB: http://www.rightdiagnosis.com/i/infectious_arthritis/intro.htm 10060968 arthritis infective AE HPO: HP_0003095 SIDER: C0003869 a pain AE that has an outcome of back pain According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10003988 back pain AE CTCAE:E12388 HPO: HP_0003418 NCIt:C41830 SIDER: C0004604 a hair AE that has an outcome of alopecia and occurs after a medical intervention. VAE, MW 10001760 alopecia means the absence of hair or loss of hair. It is not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition. alopecia AE CTCAE:E13611 HPO: HP_0001596 MP: MP_0000414 NCIt:C50575 SIDER: C0002170 a hemorrhage AE that has an outcome of gastrointestinal hemorrhage gastrointestinal haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/gastrointestinal+hemorrhage 10017955 bleeding in the stomach and/or the intestines gastrointestinal hemorrhage AE MP: MP_0000465 a movement disorder AE that has an outcome of eyes gaze upward According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH eyes gaze upward AE a nervous system AE that shows a damage to or disease affecting the nerves. Neuropathy is often classified according to the types or location of nerves that are affected. Neuropathy can also be classified according to the disease causing it. (For example, neuropathy from the effects of diabetes is called diabetic neuropathy. Ref: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy. YH, RR WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy WEB: http://www.medicalnewstoday.com/articles/147963.php WEB: http://www.neuropathy.org/ 神经病变 neuropathy AE HPO: HP_0007141 SIDER: C0442874 a skin adverse event that has an outcome of skin nodule According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). YH skin nodule AE HPO: HP_0200036 SIDER: C0037287 a movement disorder AE that has an outcome of arthrosis. YH Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage. arthrosis AE a muscle adverse event which has an outcome of hypokinesia, refering to slow or diminished movement of body musculature. YH 10021021 hypokinesia AE HPO: HP_0002375 SIDER: C0086439 Muscle twitch AE is a twitching AE that is a small, local, involuntary muscle contraction and relaxation which may be visible under the skin. JX, YH WEB: http://en.wikipedia.org/wiki/Fasciculation fasciculation AE muscle contraction AE myokymia AE 10028346 muscle twitch AE skin discoloration AE is a skin adverse event that results in change in color of skin or mucus membranes According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH, SS skin discolouration AE 10040829 skin discoloration AE a varicella zoster virus infection AE that occurs in adults and rarely in children. YH herpes zoster AE zoster AE WEB: http://www.mayoclinic.org/diseases-conditions/shingles/basics/causes/con-20019574 10019974 Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles (an illness with very different symptoms) often many years after the initial infection. shingles AE HPO: HP_0005353 SIDER: C0019360 a movement disorder AE that has an outcome of laryngismus According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH laryngospasm sudden laryngeal spasm with crowing inhalation and cyanosis Laryngismus is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. laryngismus AE a behavior and neurological AE that has an outcome of disorder in speech YH 10041466 speech disorder AE HPO: HP_0006977 SIDER: C0037822 a cardiovascular disorder AE that has an outcome of hemorrhage bleeding AE haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage 10055798 loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels hemorrhage AE MP: MP_0001914 a bone disorder AE which has an outcome of neck rigidity YH neck rigidity AE a nervous system AE that has the symptom of GBS. Guillain-Barre syndrome (GBS) is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barre occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm. YH, SS GBS AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299621 10018767 Guillain-Barre syndrome AE HPO: HP_0007131 SIDER: C0018378 an abnormal digestion AE which has an outcome of nausea and vomiting According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). This term will most likely removed since it is just a combination of nausea and vomiting. YH nausea and vomiting AE a sudden death AE that occurs to an infant. According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). YH sudden infant death AE a fever AE that has an outcome of fever with chills, which is successive stages of chills and fever. This is a symptom of malaria. YH chills and fever AE 10016559 fever with chills AE a psychiatric disorder AE that is characterized by enduring maladaptive patterns of behavior, cognition, and inner experience, exhibited across many contexts and deviating markedly from those accepted by the individual's culture. YH, MW WEB: https://en.wikipedia.org/wiki/Personality_disorder 10034721 personality disorder AE HPO: HP_0000751 SIDER: C0031212 a respiratory system AE which has an outcome of lung disorder YH lung disorder AE 10025082 lung AE HPO: HP_0006552 SIDER: C0024115 a musculoskeletal system AE that occurs in muscle. YH muscle AE an adverse event that occurs in liver, biliary, and pancreatic areas. YH, JX liver, biliary, and pancreatic disorder AE URL: http://www.ijhpd.com/ WEB: http://www.uchospitals.edu/online-library/content=P00670 hepatobiliary or pancreatic AE a liver/biliary system AE which has an outcome of an enlarged liver, or larger than average size of the liver According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly' was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). enlarged liver AE MP: MP_0000599 a brain inflammation AE which results in an inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases. YH, JX WEB: http://www.cdc.gov/meningitis/index.html 脑膜炎 10027199 meningitis AE CTCAE: E11458 HPO: HP_0001287 NCIt: C26828 SIDER: C0025289 an AE that occurs in digestive system. YH digestive system AE a paralysis AE that has an outcome of paralysis in face According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). YH facial paralysis AE HPO: HP_0007209 SIDER: C0015469 a psychiatric disorder AE that has an outcome of confusion, which is a mild form of delirium. YH, KM confused state AE mental confusion AE WEB: http://medical-dictionary.thefreedictionary.com/mental+confusion 10010300 10010305 confusion AE CTCAE: E12889 NCIt: C37928 a musculoskeletal system AE which has an outcome of joint disorder YH joint disorder AE an AE that occurs in eye. YH eye disorder AE 10015916 eye AE HPO: HP_0000496 SIDER: C0015397 a behavior and neurological AE that has an outcome of autism YH Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. autism AE a hematopoietic system AE which has an outcome of sedimentation rate increased According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term should be inferred to lab test abnormal. YH ESR erythrocyte sedimentation rate red blood cell sedimentation rate increased AE sedrate Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short. red blood cell sedimentation rate increased AE is an AE: sedimentation rate increased that has an increase in rate at which red blood cells precipitate in a period of 1 hour. sedimentation rate increased AE an arthritis AE that has an outcome of arthritis due to an infection in another part of the body DJ, SS, YH, DA reactive arthritis AE reiter's syndrome AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/16822921 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563769/ https://www.ncbi.nlm.nih.gov/pubmed/18436339 10003267 10038294 arthritis reactive AE an abnormal vision AE which has an outcome of amblyopia YH 10001906 amblyopia AE HPO: HP_0000646 SIDER: C0002418 a psychiatric disorder AE that has an outcome of mental retardation YH mental retardation AE HPO: HP_0001249 SIDER: C0025362 a rash AE which shows red, target-shaped or "bulls-eye" patches or sores on the skin. YH, MW WEB: http://kidshealth.org/parent/infections/skin/erythema_multiforme.html WEB: https://en.wikipedia.org/wiki/Erythema_multiforme 10015218 The erythema multiforme rash usually begins on the arms, hands, legs, and feet, but you might also find it on the face, neck, and body. It also can affect the lips and inside the mouth. It usuallys follows an infection or drug exposure. erythema multiforme AE CTCAE:E13627 HPO: HP_0010783 NCIt:C3024 SIDER: C0014742 a lab test abnormal AE that has an outcome of SGOT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST). SGOT increased AE a lab test abnormal AE that has an outcome of SGPT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT). SGPT increased AE a behavioral and neurological AE that has an outcome of thinking abnormality According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH, JX 10043431 thinking abnormality AE an abnormal digestion AE which has an outcome of dyspepsia According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH 10013946 Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating. dyspepsia AE CTCAE: E10617 HPO: HP_0002577 NCIt: C26756 SIDER: C0013395 an allergy AE which has an outcome of anaphylactoid reaction AE is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22293078 10002198 10002216 anaphylactoid reaction AE HPO: HP_0100845 SIDER: C0340865 a digestive system AE which has an outcome of a gastrointestinal disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH gastrointestinal disorder AE HPO: HP_0011024 SIDER: C0017178 an edema AE that has an outcome of accumulation of fluid in the peritoneal cavity DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23296107 10003445 ascites AE CTCAE: E10502 HPO: HP_0001541 NCIt: C2885 SIDER: C0003962 a hypersensitivity AE which has an outcome of serum sickness According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10040400 Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). serum sickness AE CTCAE: E11276 NCIt: C79718 an abscess AE which has an outcome of injection-site abscess YH injection-site abscess AE a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of a procedure that uses small, flat metal discs (electrodes) attached to your scalp to detect electrical activity in your brain According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, EB WEB: http://www.mayoclinic.com/health/eeg/MY00296 10000130 abnormal electroencephalogram result AE a dizziness AE that has an outcome of vertigo According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH 10047340 Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking. vertigo AE CTCAE: E10291 HPO: HP_0002321 NCIt: C38057 SIDER: C0042571 a cardiac disorder AE that has an outcome of heartarrest, the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole. YH cardiopulmonary arrest circulatory arrest heart arrest AE WEB: http://en.wikipedia.org/wiki/Myocardial_infarction WEB: http://medical-dictionary.thefreedictionary.com/cardiac+arrest 10007515 10007617 10028596 cardiac arrest CTCAE: E10101 NCIT: C50479 a respiratory system inflammation AE which has an outcome of bronchitis YH Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes. bronchitis AE HPO: HP_0002837 SIDER: C0006277 a seizure AE that has an outcome of grand malconvulsion YH A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). grand malconvulsion AE a liver related investigation result abnormal AE which shows an abnormal test result in a liver function test, indicating aberrant function of liver. According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). WEB: http://medical-dictionary.thefreedictionary.com/hepatic+function 10019670 10024690 liver function test abnormal AE MP: MP_0000609 an AE that occurs in ear. YH ear disorder AE ear AE HPO: HP_0000598 SIDER: C0013447 an infection AE that results in detrimental colonization of a host organism by virus YH, SS viral infection WEB: http://en.wikipedia.org/wiki/Viral_infection viral infection AE HPO: HP_0005364 SIDER: C0042769 a movement disorder AE that has an outcome of lacrimation disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH Lacrimation is the production, secretion, and shedding of tears. lacrimation disorder AE a liver/biliary system AE which has an outcome of jaundice, which is the clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). SS, YH icterus AE WEB: http://en.wikipedia.org/wiki/Jaundice 10023126 jaundice AE HPO: HP_0000952 MP: MP_0000611 SIDER: C0022346 an immune system disorder AE which shows an enclosed collection of liquefied tissue, known as pus, somewhere in the body. Abscess is the result of the body's defensive reaction to foreign material. YH abscessus WEB: http://medical-dictionary.thefreedictionary.com/abscess 10000269 An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body. abscess AE HPO: HP_0002722 SIDER: C0000833 a pain AE that has an outcome of eye pain According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH 10015958 eye pain AE CTCAE: E10376 HPO: HP_0200025 NCIt: C78287 SIDER: C0151827 a sensory capability AE that has an outcome of palpitation YH WEB: http://en.wikipedia.org/wiki/Palpitations 10033557 A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency. palpitation AE an edema AE which has an outcome of tongue edema YH, RR tongue oedema AE tongue swelling AE WEB: http://www.medterms.com/script/main/art.asp?articlekey=97582 10042727 tongue edema AE a pain AE that has an outcome of ear pain According to the Vaccine Adverse Event Reporting System (VAERS), 'ear pain' was mentioned in 302 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH 10014020 ear pain AE CTCAE: E10262 HPO: HP_0010833 NCIt: C37944 SIDER: C0013456 an edema AE which has an outcome of angioedema YH, SJ angioneurotic edema WEB: http://www.mayoclinic.org/diseases-conditions/hives-and-angioedema/basics/definition/con-20014815 10002473 Angioedema is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues often around the eyes and lips. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis. angioedema AE An arthritis AE that has the outcome of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body. YH rheumatoid arthritis AE HPO: HP_0005681 SIDER: C0003873 an AE that occurs in immune system. According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH immune system disorder AE immune system AE HPO: HP_0002715 SIDER: C0021053 an immune system disorder AE which has an outcome of antinuclear antibody present According to the Vaccine Adverse Event Reporting System (VAERS), 'antinuclear antibody present'; is an adverse event that was mentioned in 288 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH anti-nuclear factor present The presence of anti-nuclear antibodies (ANAs) that are antibodies directed against contents of the cell nucleus. ANAs are present in higher than normal numbers in autoimmune disease. The ANA test measures the pattern and amount of autoantibody which can attack the body's tissues as if they were foreign material. Autoantibodies are present in low titers in the general population, but in about 5% of the population, their concentration is increased, and about half of this 5% have an autoimmune disease. antinuclear antibody present AE a nervous system AE which involves inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs. YH, MW 10028524 myelitis AE CTCAE: E12732 NCIt: C26832 a headache AE that has an outcome of migraine According to the Vaccine Adverse Event Reporting System (VAERS), 'migraine'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH migraine headache A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit. migraine AE HPO: HP_0002076 SIDER: C0149931 Thrombocytopenic purpura AE are purpura AE associated with a reduction in circulating blood platelets which can result from a variety of causes. According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenic purpura'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH 10043561 thrombocytopenic purpura AE HPO: HP_0004829 SIDER: C0857305 multiple sclerosis AE is an immune system disorder AE, or an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination. YH MS disseminated sclerosis encephalomyelitis disseminata 10028245 multiple sclerosis AE a behavior and neurological AE that has an outcome of amnesia in a patient YH, MW 10001949 Amnesia is a short term memory condition in which memory is disturbed. In simple terms it is the loss of memory. amnesia AE CTCAE:E12585 HPO: HP_0002354 NCIt:C2867 SIDER: C0002622 a movement disorder AE that has an outcome of incoordination According to the Vaccine Adverse Event Reporting System (VAERS), 'incoordination' was mentioned in 261 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH a lack of normal adjustment of muscular action so that the intended movement of the limb or other part is not made smoothly and harmoniously, and does not accurately achieve its objective. If the abnormality is hypermetric, the condition is referred to as ataxia. If it is inclined to weakness, e.g. knuckling at the turn, stumbling, failure to flex limbs properly, or to misdirection as in a proprioceptive deficit, it is called incoordination. incoordination AE a speech disorder that has an outcome of voice alteration YH, MW 10047681 voice alteration AE CTCAE: E13601 NCIt: C61043 a pregnancy AE that is the termination of a pregnancyby the removal or expulsion from the uterus of a fetus or embryo, resulting in or caused by its death. According to the Vaccine Adverse Event Reporting System (VAERS), 'abortion'; is an adverse event that was mentioned in 257 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH, SS WEB: http://en.wikipedia.org/wiki/Abortion 10000210 abortion AE a psychiatric disorder AE that has an outcome of shock YH acute stress disorder AE acute stress reaction AE mental shock AE 10001084 Mental shock (or shock) is a psychological condition arising in response to a terrifying event. It should not be confused with the unrelated circulatory condition of shock. There are two types of shocks. Another is circulatory shock which is physiological with MedDRA ID of 10040560. psychological shock AE a skin discoloration AE which has an outcome of purpura According to the Vaccine Adverse Event Reporting System (VAERS), 'purpura'; is an adverse event that was mentioned in 251 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH, MW 紫癜 10037549 Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia. Reference: http://en.wikipedia.org/wiki/Purpura. purpura AE CTCAE:E13690 HPO: HP_0000979 NCIt:C78787 SIDER: C0034150 an infection AE that results in detrimental colonization of a host organism by bacteria YH, SS bacterial infection AE WEB: http://en.wikipedia.org/wiki/Bacterial_infection 10060945 bacterial infection AE HPO: HP_0002718 SIDER: C0004623 a skin adverse event that has an outcome of skin striae that displays irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions. According to the Vaccine Adverse Event Reporting System (VAERS), 'skin striae'; is an adverse event that was mentioned in 247 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH stretch marks striae distensae skin striae AE HPO: HP_0001065 SIDER: C0152459 a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention. YH acute brain syndrome AE a sensory capability AE that has an outcome of coma YH 10010071 Coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions. coma AE HPO: HP_0001259 SIDER: C0009421 a muscle adverse event which has an outcome of hyperkinesia, an abnormal increase in muscular activity. YH 10020651 hyperkinesia AE HPO: HP_0002487 SIDER: C0424295 an AE that occurs in cardiovascular system. YH cardiovascular disorder AE 10007649 cardiovascular AE HPO: HP_0001626 SIDER: C0007222 a nervous system AE which has an outcome of encephalopathy, which is disorder or disease of the brain. YH, MW 10014625 encephalopathy AE CTCAE:E12652 HPO: HP_0007239 NCIt:C26920 SIDER: C0085584 a urinary system AE that has an outcome of urine abnormality AE YH urine abnormality AE HPO: HP_0011036 SIDER: C0235639 a gastrointestinal disorder AE which has an outcome of gastroenteritis, an inflammation occuring in the gastrointestinal tract that involves both the stomach and the small intestine, often results in diarrhea, vomiting and abdominal pain and cramping According to the Vaccine Adverse Event Reporting System (VAERS), 'gastroenteritis' was mentioned in 218 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH WEB: http://medical-dictionary.thefreedictionary.com/gastroenteritis 10017888 gastroenteritis AE HPO: HP_0004386 SIDER: C0017160 a cardiovascular disorder AE that has an outcome of peripheral vascular disorder YH peripheral vascular disorder AE HPO: HP_0005299 SIDER: C0085096 a urinary tract disoder AE that has an outcome of urnary tract infection AE YH 10046571 urinary tract infection AE CTCAE: E11614 HPO: HP_0000094 NCIt: C50791 SIDER: C0042029 an abnormal salivary gland physiology AE which has an outcome of increased salivation, meaning greater than normal amounts of flowing saliva According to the Vaccine Adverse Event Reporting System (VAERS), 'increased salivation' is an adverse event that was mentioned in 336 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). increased salivation AE MP: MP_0000622 a psychiatric disorder AE that has an outcome of depression. Depression causes a persistent feeling of sadness and loss of interest. YH, MW WEB: http://www.mayoclinic.org/diseases-conditions/depression/basics/definition/con-20032977 10012378 depression AE CTCAE:E12909 HPO: HP_0000716 NCIt:C2982 SIDER: C0011570 a glucose homeostasis AE which has an outcome of diabetes mellitus YH diabetes AE 10012601 Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia). diabetes mellitus AE HPO: HP_0000819 SIDER: C0011849 a respiratory system inflammation AE which has an outcome of laryngitis According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngitis'; is an adverse event that was mentioned in 190 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10023874 Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice because of irritation to the vocal folds (vocal cords). laryngitis AE CTCAE: E11435 HPO: HP_0001600 NCIt: C26811 SIDER: C0023067 a muscle spasm AE which has an outcome of generalized spasm, which is an involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH). YH generalized spasm AE According to the Vaccine Adverse Event Reporting System (VAERS), 'reflexes decreased'; is an adverse event that was mentioned in 178 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH hyporeflexia AE Obsoleted because of duplication. It's an alternative term of hyporeflexia AE now. a movement disorder AE that has an outcome of reflexes decreased, an abnormal decrease in an involuntary response to a peripheral stimulus obsolete: reflexes decreased AE a digestive system AE which has an outcome of dry mouth, which is dryness of the mouth resulting from reduced salivary secretion According to the Vaccine Adverse Event Reporting System (VAERS), 'dry mouth'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH xerostomia 10013781 dry mouth AE CTCAE: E10578 HPO: HP_0000217 NCIt: C26917 SIDER: C0043352 a neuritis AE which has an outcome of optic neuritis YH 10030942 optic neuritis AE HPO: HP_0100653 SIDER: C0029134 a cardiovascular disorder AE that has an outcome of thrombocythemia YH Thrombocythemia (primary thrombocythemia) is a disorder in which excess platelets are produced, leading to abnormal blood clotting or bleeding. thrombocythemia AE - OBSOLETE (due to duplication) a hemorrhage AE that has an outcome of epistaxis YH, MW nosebleed 10015090 Epistaxis is the relatively common occurrence of hemorrhage from the nose, usually noticed when the blood drains out through the nostrils. epistaxis AE CTCAE:E13374 HPO: HP_0000421 NCIt:C26766 SIDER: C0014591 a syndrome AE that displays a lupus syndrome. Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. This results in symptoms such as inflammation, swelling, and damage to joints, skin, kidneys, blood, the heart, and lungs. YH, JX lupus syndrome AE 狼疮样综合征 WEB: http://www.medicalnewstoday.com/info/lupus/ lupus AE an eye disorder AE which has an outcome of photophobia YH 10034960 Photophobia is a symptom of excessive sensitivity to light and the aversion to sunlight or well-lit places. In medical terms it is not fear, but an experience of discomfort or pain to the eyes due to light exposure. photophobia AE CTCAE: E10416 HPO: HP_0000613 NCIt: C28210 SIDER: C0085636 a digestive system AE which has an outcome of abnormal salivary gland physiology, which is any functional anomaly of any of the glands in the mouth that secrete saliva abnormal salivary gland physiology AE MP: MP_0005310 a psychiatric disorder AE that has an outcome of hallucination YH, MW hallucinations AE 10019063 10019077 A hallucination, in the broadest sense, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space. hallucination AE CTCAE: E12919 HPO: HP_0000738 NCIt: C37961 SIDER: C0018524 a digestive system AE which has an outcome of tongue disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue disorder'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH tongue disorder HPO: HP_0000157 SIDER: C0040409 a pain AE that has an outcome of neuralgia According to the Vaccine Adverse Event Reporting System (VAERS), 'neuralgia'; is an adverse event that was mentioned in 155 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10029223 Neuralgia or neuropathic pain can be defined most simply as non-nociceptive pain. Neuralgia is pain produced by a change in neurological structure or function. Unlike nociceptive pain, Neuralgia exists with no continuous nociceptive input. Neuralgia falls into two categories: central Neuralgia and peripheral Neuralgia. neuralgia AE CTCAE:E12744 HPO: HP_0003489 NCIt:C79695 SIDER: C0027796 an edema AE which has an outcome of lung edema YH lung edema AE a paresthesia AE that occurs around the mouth. YH circumoral paresthesia AE HPO: HP_0003401 SIDER: C0151838 an abnormal fluid regulation AE which has an outcome of thirst YH 10043458 Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance. thirst AE HPO: HP_0001959 SIDER: C0039971 a musculoskeletal system AE that occurs in the bone YH bone disorder 10005956 bone AE HPO: HP_0000924 SIDER: C0005940 a perinatal AE that displays fetal disorder. YH fetal disorder AE a sensory capability AE that has an outcome of emotional liability YH emotional liability AE a muscle adverse event which has an outcome of muscle spasm, which is an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions SS, YH WEB: http://en.wikipedia.org/wiki/Spasm 10028334 muscle spasm AE MP: MP_0000743 a connective tissue disorder AE that occurs at the location of tendon A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension. According to the Vaccine Adverse Event Reporting System (VAERS), 'tendon disorder'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH Tendon disorder is a medical condition that results in a tendon not functioning normally. tendon disorder AE a behavior and neurological AE that has an outcome of hostility YH 10020400 hostility AE an eye disorder AE which has an outcome of visual field defect SS, YH visual impairment AE WEB: http://en.wikipedia.org/wiki/Visual_impairment 10047555 10047571 visual field defect AE a muscle adverse event which has an outcome of myopathy AE, an abnormal condition or disease of the skeletal muscle 10028641 myopathy AE HPO: HP_0003198 MP: MP_0000751 SIDER: C0026848 a behavior and neurological AE that has an outcome of apathy state YH impassivity perfunctoriness 10002942 Apathy is a state of indifference, or the suppression of emotions such as concern, excitement, motivation and passion. An apathetic individual has an absence of interest or concern to emotional, social, or physical life. They may also exhibit an insensibility or sluggishness. apathy AE HPO: HP_0000741 SIDER: C0085632 a paralysis AE that has an outcome of hemiplegia According to the Vaccine Adverse Event Reporting System (VAERS), 'hemiplegia'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10019468 Hemiplegia is total paralysis of the arm, leg, and trunk on the same side of the body. Hemiplegia is more severe than hemiparesis, wherein one half of the body is weakened but not paralysed. hemiplegia AE HPO: HP_0002301 SIDER: C0018991 a rash AE that is characterized by a circumscribed and elevated skin lesion filled with pus. According to the Vaccine Adverse Event Reporting System (VAERS), 'pustular rash'; is an adverse event that was mentioned in 128 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH rash pustular AE 10037888 pustular rash AE CTCAE: E11545 NCIt: C80119 a blood creatine phosphokinase level abnormal AE that is characterized by an increased level of creatine phosphokinase (CPK) or phosphocreatine kinase, an enzyme expressed by various tissue types that catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP) YH, EB elevated serum creatine phosphate kinase AE 10005470 blood creatine phosphokinase level increased AE a hypertension AE that has an outcome of elevated pressure in the skull. YH, SS WEB: http://www.ihrfoundation.org/intracranial/hypertension/info/C16 10049977 intracranial hypertension AE a sensory neuropathy AE which shows a painful neuropathy characterized by damage to sensory and motor nerves AG, YH sensorimotor painful neuropathy AE a digestive system AE which has an outcome of abnormal stool According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal stools' was mentioned in 111 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH abnormal stool AE a pain AE that has an outcome of bone pain According to the Vaccine Adverse Event Reporting System (VAERS), 'bone pain' was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10006002 bone pain AE CTCAE:E12392 HPO: HP_0002653 NCIt:C38644 SIDER: C0151825 a cardiovascular disorder AE that comes with cerebrovascular accident YH stroke 10008190 Cerebrovascular accident: The sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A CVA is also referred to as a stroke. cerebrovascular accident AE HPO: HP_0001297 SIDER: C0038454 a digestive system AE which has an outcome of parotid gland enlargement According to the Vaccine Adverse Event Reporting System (VAERS), 'parotid gland enlargement' was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10034023 parotid gland enlargement AE a movement disorder AE that has an outcome of flatulence According to the Vaccine Adverse Event Reporting System (VAERS), 'flatulence' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH 10016766 Flatulence is the production of a mixture of gases in the digestive tract of mammals or other animals that are byproducts of the digestion process. Such a mixture of gases is known as flatus, and is expelled from the rectum in a process colloquially referred to as "passing gas" or "farting". flatulence AE CTCAE: E10697 HPO: HP_0011024 NCIt: C37954 SIDER: C0016204 a liver/biliary system AE which has an outcome of liver damage According to the Vaccine Adverse Event Reporting System (VAERS), 'liver damage' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH liver damage AE a respiratory system AE which has an outcome of sore throat YH, MW 10041367 sore throat AE CTCAE: E13575 NCIt: C50747 a movement disorder AE that results in the loss of power of voluntary movement in a muscle through injury or disease of its nerve supply According to the Vaccine Adverse Event Reporting System (VAERS), 'paralysis' is an adverse event that was mentioned in 574 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). SS, YH WEB: https://www.nlm.nih.gov/medlineplus/paralysis.html 瘫痪 10033799 paralysis AE HPO: HP_0010549 MP: MP_0000753 SIDER: C0522224 a bone disorder AE that has an outcome of cellular death of bone components due to interupption of blood supply DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/avascular+necrosis 10003460 aseptic necrosis bone AE a physical examination result abnormal AE that has an outcome of weight loss, which is the progressive reduction of body weight below normal average for age MW, YH weight decreased AE 10047895 10047900 weight loss AE CTCAE: E12228 MP: MP_0001263 NCIt: C3445 According to the Vaccine Adverse Event Reporting System (VAERS), 'ataxia' is an adverse event that was mentioned in 555 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH, MW 10003591 a movement disorder AE that has an outcome of ataxia, inability to coordinate voluntary muscular movements ataxia AE CTCAE:E12597 HPO: HP_0001251 MP: MP_0001393 NCIt:C26702 SIDER: C0004134 a hair, skin, and nail AE that occurs in skin. YH WEB: http://www.thefreedictionary.com/skin+disorder 10040831 skin AE a movement disorder AE that has an outcome of unusual or distinctive way of walking According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal gait' is an adverse event that was mentioned in 998 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). SS, YH gait disturbance AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/21224774 10017577 abnormal gait AE CTCAE: E11112 MP: MP_0001406 NCIt: C78303 an abnormal fluid regulation AE which has an outcome of dehydration, which is an excessive water loss from the body or from an organ or bodily part YH, SS, MW hypohydration 10012174 dehydration AE CTCAE:E12258 HPO: HP_0001944 MP: MP_0001429 NCIt:C26740 SIDER: C0011175 a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid abnormal fluid regulation AE MP: MP_0001784 a glucose homeostasis AE which has an outcome of hyperglycemia, which is an abnormally high concentration of glucose in the blood; generally refers to a pathological state YH, MW WEB: http://medical-dictionary.thefreedictionary.com/hyperglycemia 10020635 10020639 hyperglycemia AE CTCAE: E12276 MP: MP_0001559 NCIt: C26797 a homeostasis AE which has an outcome of abnormal ciculating bilirubin level, which is aberrant concentration in the blood of this yellow heme breakdown product According to the Vaccine Adverse Event Reporting System (VAERS), 'bilirubinemia'; is an adverse event that was mentioned in 221 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). abnormal circulating bilirubin level AE MP: MP_0001569 a skin adverse event that has an outcome of cyanosis, a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood According to the Vaccine Adverse Event Reporting System (VAERS), 'cyanosis' is an adverse event that was mentioned in 1,804 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). 10011703 cyanosis AE HPO: HP_0000961 MP: MP_0001575 SIDER: C0010520 a hematopoietic system AE which has an outcome of anemia, which is less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs anaemia AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001586/ 10002034 10002272 anemia AE CTCAE: E10010 MP: MP_0001577 NCIt: C2869 an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states YH, MW blood pressure decreased, low blood pressure 10005734 10021097 hypotension AE CTCAE: E13791 HPO: HP_0002615 MP: MP_0001596 NCIt: C3128 SIDER: C0020649 an arrhythmia AE that has an outcome of uneven timing of heart contraction irregular heartbeat AE MP: MP_0001636 an electrolyte lab test abnormal AE that shows an abnormal level of an electrolyte in the blood YH, MW electrolyte blood test abnormal AE a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy abnormal digestion AE MP: MP_0001664 an AE that occurs in the homeostasis system. anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues homeostasis AE MP: MP_0001764 an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues oedema, swelling, dropsy WEB: http://en.wikipedia.org/wiki/Oedema WEB: http://en.wikipedia.org/wiki/Swelling_(medical) 10016807 10030095 10042674 edema AE MP: MP_0001785 an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult. SS, YH WEB: http://en.wikipedia.org/wiki/Inflammation 10061218 inflammation AE HPO: HP_0007891 MP: MP_0001846 SIDER: C0021368 an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). brain inflammation AE MP: MP_0001847 an ear disorder AE which has an outcome of increased susceptibility to otitis media, which is greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection increased susceptibility to otitis media AE MP: MP_0001850 an eye disorder AE which has an outcome of eye inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the eye 10015943 eye inflammation AE HPO: HP_0100533 MP: MP_0001851 SIDER: C0239429 an eye inflammation AE which has an outcome of conjunctivitis, which is inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball 10010741 conjunctivitis AE CTCAE: E10355 HPO: HP_0000509 MP: MP_0001852 NCIt: C34504 SIDER: C0009763 an inflammation AE that shows a local accumulation of fluid, plasma proteins, and leukocytes in the liver According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatitis' was mentioned in 387 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, JX liver inflammation AE MP: MP_0001860 aa inflammation AE which has an outcome of lung inflammation, a local accumulation of fluid, plasma proteins, and leukocytes in the lung According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). lung inflammation AE MP: MP_0001861 an inflammation AE which occurs in the respiratory system, which is reflected with the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system respiratory system inflammation AE MP: MP_0002405 an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel It's an inflammation. YH, MW 10047115 vasculitis AE CTCAE:E13837 HPO: HP_0002633 MP: MP_0001864 NCIt:C26912 SIDER: C0042384 an inflammation AE which has an outcome of salivary gland inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland salivary gland inflammation AE MP: MP_0001870 a respiratory system inflammation AE which has an outcome of sinus inflammation, an inflammation of paranasal sinuses, which may be due to infection, allergy, or autoimmune issues. According to the Vaccine Adverse Event Reporting System (VAERS), 'sinusitis'; is an adverse event that was mentioned in 298 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). SS, YH, RR sinus inflammation AE WEB: http://en.wikipedia.org/wiki/Sinusitis 10040753 sinusitis AE CTCAE: E11563 HPO: HP_0000246 MP: MP_0001872 NCIt: C35024 SIDER: C0037199 a hypersensitivity AE which results in an allergic response showing a marked increase in reactivity to an antigen upon subsequent exposure. JX, LW, YH allergic reaction AE allergic response AE anaphylactic reaction AE WEB: http://en.wikipedia.org/wiki/Allergy 变态反应 过敏反应 10001718 10001738 allergy AE CTCAE: E11248 MP: MP_0001878 NCIt: C3114 a nervous system AE which has an outcome of abnormal cerebrospinal fluid production, an anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord abnormal cerebrospinal fluid production AE MP: MP_0001911 an AE that occurs in nervous system. KY, YH nervous system disorder AE URL: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/overview_of_nervous_system_disorders_85,P00799/ 10029202 nervous system AE MP: MP_0003633 a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He abnormal respiration AE MP: MP_0001943 an abnormal respiration AE which has an outcome of apnea, temporary cessation of breathing; sometimes episodic According to the Vaccine Adverse Event Reporting System (VAERS), 'apnea' is an adverse event that was mentioned in 1,618 VAERS reports (1.3%) during1991-2001 (Reference: PMID: 12825543). JX, YH, MW MedDRA: 10002974 is for "apnoea"; MedDRA: 10002972 is for "apnea". apnoea AE respiratory arrest AE WEB: http://medical-dictionary.thefreedictionary.com/apnea apnea AE CTCAE: E13306 MP: MP_0001957 NCIt: C26698 UMLS CUI: C0003578 an ear disorder AE which has an outcome of deafness, which is an inability to hear 10011878 deafness AE HPO: HP_0000365 MP: MP_0001967 SIDER: C0011053 an adverse event that occurs in a gustatory system YH, JX gustatory system AE MP: MP_0001985 a gustatory system AE which has an outcome of taste sensitivity, or changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system taste sensitivity AE MP: MP_0001986 a urinary system AE that has an outcome of excessive or abnormally large production or passage of urine. LW, ML, JX, YH WEB: http://en.wikipedia.org/wiki/Polyuria 多尿 10036142 polyuria AE an abnormal vision AE which has an outcome of blindness, which is loss of the sense of sight 10005169 blindness AE HPO: HP_0000618 MP: MP_0002001 SIDER: C0456909 an eye disorder AE which has an outcome of abnormal vision, which is an inability or decreased ability to see abnormal vision AE MP: MP_0002090 a behavior and neurological AE that shows a sudden surge of electrical activity in the brain. YH, JX, YH WEB: http://www.healthline.com/symptom/seizures 突然发作 10039906 10039910 seizure AE CTCAE: E12804 MP: MP_0002064 NCIt: C2962 an adverse event that has an outcome of an abnormal behavior and neurological phenotype. YH, JX behavior AE behavioral AE behavioral disorder AE disruptive behavioral disorder AE WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/ any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls behavioral and neurological AE MP: MP_0004924 a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements 10028035 movement disorder AE HPO: HP_0100022 MP: MP_0002066 SIDER: C0026650 a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus sensory capability AE MP: MP_0002067 a homeostasis AE which has an outcome of glucose homeostasis, which is an anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues glucose homeostasis AE MP: MP_0002078 Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal. JX, LW, YH hypersensitivity reaction AE WEB: http://en.wikipedia.org/wiki/Hypersensitivity 超敏反应 10020751 hypersensitivity AE HPO: HP_0100326 MP: MP_0002148 SIDER: C0020517 YH Muscle atrophy is a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation. a muscle adverse event AE which has an outcome of muscular atrophy. muscular atrophy AE MP: MP_0002269 an abnormal respiration AE which has an outcome of hyperventilation, i.e., increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal According to the Vaccine Adverse Event Reporting System (VAERS), 'Petechiae' was mentioned in 510 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). 10020910 hyperventilation AE HPO: HP_0002883 MP: MP_0002320 SIDER: C0020578 an abnormal respiration AE which has an outcome of hypoventilation, i.e., reduced alveolar ventilation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoventilation' is an adverse event that was mentioned in 321 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). QL, YH respiratory depression AE WEB: https://en.wikipedia.org/wiki/Hypoventilation 呼吸抑制 10021133 10038678 hypoventilation AE HPO: HP_0007110 MP: MP_0002321 SIDER: C0398353 an adverse event which occurs in a hematopoietic system, which is any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells hematopoietic system AE MP: MP_0002396 an eye disorder AE which has an outcome of mydriasis, which is dilation of one or both pupils regardless of light conditions 10028521 mydriasis AE HPO: HP_0011499 MP: MP_0002546 SIDER: C0026961 an arrhythmia AE that has an outcome of greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute tachycardia WEB: http://en.wikipedia.org/wiki/Tachycardia 10019303 increased heart rate AE MP: MP_0002626 a behavior and neurological AE that has an outcome of exaggerated reflex action hyperresponsive to tactile stimuli AE MP: MP_0002738 a muscle spasm AE that has an outcome of opisthotonus YH 10030899 opisthotonus is a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward opisthotonus AE HPO: HP_0002179 MP: MP_0002880 SIDER: C0151818 An joint disorder AE that has an outcome of joint inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the joints YH joint inflammation AE MP: MP_0002933 an abnormal enzyme level AE which has an outcome of incraesed lactate dehydrogenase level, which is greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate increased lactate dehydrogenase level AE MP: MP_0002944 an abnormal enzyme level AE which has an outcome of increased circulating alkaline phophatase level, which is an elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood increased circulating alkaline phosphatase level AE MP: MP_0002968 A joint inflammation AE that has an outcome of arthritis, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures YH, MW 关节炎 10003246 arthritis AE CTCAE:E12378 HPO: HP_0001369 MP: MP_0002993 NCIt:C2883 SIDER: C0003864 a digestive system AE which has an outcome of dysphagia, which is a behavior and neurological AE that has an outcome of difficulty in swallowing food or liquid 10013950 dysphagia AE CTCAE: E10621 HPO: HP_0002015 MP: MP_0003158 NCIt: C2980 SIDER: C0011168 an ear disorder AE which has an outcome of decreased lateral semicircular canal size, which is small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance decreased lateral semicircular canal size AE MP: MP_0003162 a hematopoietic system AE which has an outcome of decreased platelet count, which is fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation SS, YH decreased platelet cell number AE 10035528 platelet count decreased AE CTCAE: E12207 HPO: HP_0001873 MP: MP_0003179 NCIt: C3408 SIDER: C0392386 an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit 10028813 nausea AE CTCAE: E10878 HPO: HP_0002018 MP: MP_0003259; MDR: 10028813 NCIt: C3258 SIDER: C0027497 regurgitation AE 10047700 an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity vomiting AE CTCAE: E11068 HPO: HP_0002013 MP: MP_0003260; MDR: 10047700 NCIt: C3442 SIDER: C0042963 an abnormal defecation AE that has an outcome of constipation, which is incomplete, infrequent or difficult evacuation of fecal matter According to the Vaccine Adverse Event Reporting System (VAERS), 'constipation'; is an adverse event that was mentioned in 242 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). infrequent bowel movements AE 10010774 constipation AE CTCAE: E10562 HPO: HP_0002019 MP: MP_0003267 NCIt: C37930 SIDER: C0009806 a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces abnormal defecation AE MP: MP_0003866 a urinary system AE that has an outcome of the symptom of urinary incontinence, which is the inability to control the urinary excretory functions. YH, MW MedDRA: 10046543 WEB: http://www.nlm.nih.gov/medlineplus/urinaryincontinence.html urinary incontinence AE CTCAE: E13042 HPO: HP_0000020 MP: MP_0003280 NCIt: C78497 SIDER: C0042024 clonus AE is a series of involuntary, rhythmic, muscular contractions and relaxations. SJ, YH WEB: http://en.wikipedia.org/wiki/Clonus 10009346 clonus AE causes large motions that are usually initiated by a reflex. clonus AE a skin discoloration AE which has an outcome of pallor, an unnatural paleness to the skin, generally attributable to anemia 10033546 pallor AE HPO: HP_0008361 MP: MP_0003717 SIDER: C0030232 an hearing disorder AE that shows a persistent sensation of buzzing, ringing, clicking, or other noises in the ear 10043882 tinnitus AE CTCAE: E10287 HPO: HP_0000360 MP: MP_0003741 NCIt: C50772 SIDER: C0040264 a digestive system AE which has an outcome of stomatitis, which is an inflammation of the mucous lining of the mouth This is a type of inflammation. WEB: http://medical-dictionary.thefreedictionary.com/stomatitis 10042128 stomatitis AE HPO: HP_0010280 MP: MP_0003746 SIDER: C0038362 a digestive system AE which has an outcome of mouth mucosal ulceration, which is lesions through the mucous membrane of the mouth, usually associated with loss of tissue According to the Vaccine Adverse Event Reporting System (VAERS), 'mouth ulceration' was mentioned in 246 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). mouth mucosal ulceration AE MP: MP_0003747 a muscle adverse event AE that has an outcome of abnormal muscle tone, which is an anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation YH abnormal muscle tone AE MP: MP_0004142 an abnormal muscle tone AE which has an outcome of hypertonia, which is increased muscle tension resulting in stiffness of the muscles in the resting state YH 10020852 hypertonia AE HPO: HP_0001276 MP: MP_0004143 SIDER: C0026826 an abnormal muscle tone AE which has an outcome of hypotonia, which is decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness YH 10021118 hypotonia AE HPO: HP_0009062 MP: MP_0004144 SIDER: C0026827 a muscle inflammation AE which has an outcome of myositis, which is an inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle YH, MW 10028653 myositis AE CTCAE:E12489 HPO: HP_0009071 MP: MP_0004510 NCIt:C27578 SIDER: C0027121 a muscle adverse event which has an outcome of muscle inflammation, which is a local accumulation of fluid, plasma proteins, and leukocytes in muscle YH muscle inflammation AE MP: MP_0004511 a lymphocyte count abnormal AE that has an outcome of greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells According to the Vaccine Adverse Event Reporting System (VAERS), 'lymphocytosis'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). EB increased lymphocyte cell number AE lymphocyte cell number increased AE 10025258 lymphocyte count increased AE CTCAE: E12195 MP: MP_0005013 NCIt: C34791 an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel diarrhoea AE WEB: http://medical-dictionary.thefreedictionary.com/diarrhea 10012735 diarrhea AE CTCAE: E10572 MP: MP_0005036 NCIt: C2987 a homeostasis AE which has an outcome of hypoxia, which is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases YH, MW WEB: http://medical-dictionary.thefreedictionary.com/hypoxia 10021143 hypoxia AE CTCAE:E13388 HPO: HP_0002795 MP: MP_0005039 NCIt:C3890 SIDER: C0242184 an infectious adverse event which has an outcome of the presence of various pathogenic organisms, or their toxins, in the blood or tissues that results in the infections in blood stream. According to the Vaccine Adverse Event Reporting System (VAERS), 'sepsis' was mentioned in 416 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). SS 10040047 sepsis AE CTCAE: E11560 HPO: HP_0002718 MP: MP_0005044 NCIt: C3364 SIDER: C0243026 a urinary system AE that results in the presence of blood in the urine YH, SJ, MW UMLS CUI: C0018965 (hematuria AND haematuria); UMLS CUI: C0947999 (blood urine presence) blood urine blood urine presence haematuria AE WEB: http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/ 10018867 10018870 10019450 hematuria Hematuria AE can be caused by menstruation, vigorous exercise, sexual activity, viral illness, trauma, or infection, such as a urinary tract infection (UTI), along with more serious disorders such as cancer, disease, and clotting. hematuria AE CTCAE: E13000 MP: MP_0005161 NCIt: C3090 a homeostasis AE which has an outcome of abnormal enzyme level, which is an altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances abnormal enzyme level AE MP: MP_0005319 an arrhythmia AE that has an outcome of fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute YH, JX heart rate decreased AE 10019301 decreased heart rate AE MP: MP_0005333 an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine YH urinary system AE MP: MP_0005502 an abnormal body temperature AE which has an outcome of decreased body temperature, which is less than the level of heat natural to a living being YH, SJ decreased body temperature AE 10021113 Hypothermia AE is a medical emergency that occurs when your body loses heat faster than it can produce heat, causing a dangerously low body temperature. hypothermia AE CTCAE: E11122 MP: MP_0005534 NCIt: C78351 a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being abnormal body temperature AE MP: MP_0005535 a peripheral neuropathy AE which has an outcome of neuritis, the local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord 10029240 neuritis AE MP: MP_0006082 diplopia AE 10013036 an abnormal vision AE which has an outcome of double vision, which is two images perceived when only a single object is present double vision AE MP: MP_0006150 an anemia AE which has an outcome of hypochromic anemia, which is a hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs hypochromic anemia AE MP: MP_0008387 an adverse event that is indicated by an abnormal result of an investigation that uses some laboratory equipment, device, or medical technology. This term is used to replace 'lab test abnormal AE'. The reason for this is that some test, like X-ray test, is not considered by many physicians as a lab test. Therefore, we have used this new term to cover a broader scope. All terms asserted under this term represent the investigation results without defined conclusion of disease. EB, SS, YH laboratory test abnormal 10061253 investigation result abnormal AE a movement disorder AE that has an outcome of nervous According to the Vaccine Adverse Event Reporting System (VAERS), 'nervousness' is an adverse event that was mentioned in 583 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). increased, skittish, behavior induced by stimulation such as handling, touching or noise nervous AE MP: MP_0008912 a hemorrhage AE that has an outcome of ecchymosis 10014080 an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis ecchymosis AE HPO: HP_0000978 MP: MP_0009276 SIDER: C0013491 serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death. YH, MC serious adverse event severe adverse event WEB: http://en.wikipedia.org/wiki/Serious_adverse_event WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA serious adverse event a serious adverse event that has an outcome of death. YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm 10011906 10011914 death death AE CTCAE: E11080 HPO: HP_0001645 NCIt: C28554 SIDER: C1306577 a serious AE that is suspected to put the patient at substantial risk of dying at the time of the adverse event, or that the use or continued use of the device or other medical product might have resulted in the death of the patient. DJ, SS, YH, JX apparent life threatening event AE WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm 10065044 life-threating AE a serious adverse event that leads to hospitalization. Such an adverse event resulted in an admission to the hospital or prolongation of hospitalization. YH, JX adverse event leading to hospitalization WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm hospitalization AE a serious adverse event that leads to disability or permanent damage. Such an adverse event results in a substantial disruption of a person's ability to conduct normal life functions, i.e., the adverse event resulted in a significant, persistent or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities and/or quality of life. YH, JX adverse event leading to disability WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm disability or permanent damage AE a serious adverse event that resulted in congenital anomaly and bith defect, leading to suspicions that an exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child. YH, JX adverse event leading to congenital anomaly WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.thefreedictionary.com/birth+defect 10010356 congenital anomaly or birth defect AE a serious adverse event which is an adverse event that requires intervention to prevent permanent impairment or damage leads to suspicions that the use of a medical product may result in a condition which requires a medical or surgical intervention to preclude permanent impairment or damage to a patient. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm adverse event that requires intervention to prevent permanent impairment or damage an adverse event that is considered not serious. YH, MC WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA non-serious adverse event low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C). YH WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 The low-grade level of fever is beneficial. With most microbes/"bugs" that a child will be exposed to, this fever will assist the body in repelling the invader. low-grade fever AE moderate-grade fever AE is a fever adverse event with a temperature typically between 102.2° F and 104.5° F (39° C and 40° C). YH WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 This moderate-grade fever temperature is still considered beneficial. If a child's body has reached this temperature, it's what's needed to kill whatever bacteria or virus their body is attempting to fight. moderate-grade fever AE high-grade fever AE is a fever adverse event with a fever temperature greater than 104.5° F (40° C). YH WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 This fever may cause the child some discomfort and result in crankiness. Generally indicative of a bacterial infection, this fever means that the body is fighting something more serious than the common cold. high-grade fever AE hyperpyrexia AE is a fever adverse event that has an outcome of an excessive and unusual elevation of set body temperature greater than or equal to 41 °C. It is an extremely high fever. Such a high temperature is considered a medical emergency as it may indicate a serious underlying condition such as sepsis. YH extreme pyrexia AE Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. WEB: http://en.wikipedia.org/wiki/Hyperpyrexia 10020741 hyperpyrexia AE HPO: HP_0001945 SIDER: C0392676 a pain AE that has an outcome of musculoskeletal pain SS, YH WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain 10028391 Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones. musculoskeletal pain AE HPO: HP_0003326 SIDER: C0026858 injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection SS, YH WEB: http://en.wikipedia.org/wiki/Erythema WEB: http://medical-dictionary.thefreedictionary.com/erythema 10022061 injection-site erythema AE Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin. SS, YH reddish skin WEB: http://en.wikipedia.org/wiki/Erythema 10015150 erythema AE HPO: HP_0010783 MP:0001190 SIDER: C0041834 a headache AE that has an outcome of sinus headache YH, SS WEB: http://american-rhinologic.org/patientinfo.headache.phtml sinus headache is a headache located over the sinuses, (forehead, corners of the eye, and cheek areas). On occasion, the pain will be felt behind the eyes, in the back of the neck, or may extend into the upper teeth. sinus headache AE HPO: HP_0002315 SIDER: C0037195 an inflammation AE that occurs in the lung. It is often characterized as including inflammation of the parenchyma of the lung (that is, the alveoli) and abnormal alveolar filling with fluid (consolidation and exudation). SS, YH WEB: http://en.wikipedia.org/wiki/Pneumonia 10035664 pneumonia AE HPO: HP_0002090 SIDER: C0032285 lobar pneumonia is pneumonia AE that affects a large and continuous area of the lobe of a lung SS, YH WEB: http://en.wikipedia.org/wiki/Lobar_pneumonia 10024738 lobar pneumonia AE HPO: HP_0002090 SIDER: C0032300 axillary pain AE is a pain AE that occurs in the underarm (the area on the human body directly under the join where the arm connects to the shoulder) SS, YH axillary pain AE an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma". SS, YH bruise AE bruising AE ecchymoses AE haematoma AE WEB: http://en.wikipedia.org/wiki/Hematoma 10006504 10018852 10019428 hematoma AE CTCAE: E13775 (hematoma); CTCAE: E11666 (brruising) HPO: HP_0001892 NCIt: C37921 (Bruising); NCIt: C50579 (Hematoma) SIDER: C0018944 reproductive system AE is an AE that occurs in the reproductive system. YH, SS reproductive system AE an immune system disorder AE which has an outcome of antinuclear antibody negative SS, YH antinuclear antibody negative AE a CSF test result abnormal AE that has an outcome of CSF white blood cell count negative SS, YH, EB 10061099 CSF white blood cell count negative AE a microbiology and serology investigation result abnormal AE that has an outcome of positive influenza serology test result SS, YH, EB 10060078 influenza serology positive AE YH a paralysis AE that has an outcome of VIIth nerve paralysis 10050040 VIIth nerve paralysis AE HPO: HP_0006824 SIDER: C0919980 an aspartate aminotransferase level abnormal AE that has an outcome of an increased amount of AST, an enzyme normally present in body tissues especially of the heart and liver DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/aspartate+aminotransferase 10003481 aspartate aminotransferase level increased AE CTCAE: E12087 NCIt: C26947 an incorrect dose administration that accidentally uses overdose SS, YH 10000381 accidental overdose in medical intervention an immune system disorder AE which has an outcome of acute disseminated encephalomyelitis SS, YH WEB: http://en.wikipedia.org/wiki/Acute_disseminated_encephalomyelitis 10000709 Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually occurs following a viral infection but may appear following vaccination, bacterial or parasitic infection, or even appear spontaneously. As it involves autoimmune demyelination, it is similar to multiple sclerosis, and is considered part of the Multiple sclerosis borderline diseases. acute disseminated encephalomyelitis AE an arrhythmia AE that involves the two upper chambers (atria) of the heart SS, YH AF WEB: http://en.wikipedia.org/wiki/Atrial_fibrillation WEB: http://medical-dictionary.thefreedictionary.com/atrial+fibrillation 10003658 Atrial fibrillation (AF or A-fib) is the most common cardiac arrhythmia (abnormal heart rhythm), and involves the two upper chambers (atria) of the heart. Its name comes from the fibrillating (i.e., quivering) of the heart muscles of the atria, instead of a coordinated contraction. atrial fibrillation AE CTCAE: E10081 HPO: HP_0005110 NCIt: C50466 SIDER: C0004238 a cardiac disorder AE which has an outcome of abnormal heart rhythm SS, YH abnormal heartbeat AE cardiac arrhythmia AE WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/arr/ 10003119 arrhythmia AE HPO: HP_0011675 MP: MP_0004085 SIDER: C0003811 a cardiac valve disease AE that is characterized by a condition of the heart in which one of the valve openings has become narrow and restricts the flow of blood from the upper left chamber (left atrium) to the lower left chamber (left ventricle). SS WEB: http://medical-dictionary.thefreedictionary.com/mitral+valve+stenosis 10027733 mitral valve stenosis AE a blood creatinine level abnormal AE that has an outcome of decreased blood creatine SS, YH, EB 10005482 blood creatinine level decreased AE SS, YH, EB 10007223 carbon dioxide decreased AE a carbon dioxide abnormal AE that has an outcome of a decreased level of carbon dioxide in the blood A contraindication that is specifically for vaccination. SS, YH contraindication to vaccination an infection adverse event that has an outcome of croup infection SS, YH WEB: http://www.medicinenet.com/croup/article.htm Croup is an infectious illness of the respiratory system involving the vocal cords (larynx), the windpipe (trachea), and the upper airways of the lungs (bronchial tubes). The majority of a child's symptoms reflect involvement of the larynx. Croup is usually a viral infection and maybe caused by many different viruses, including those responsible for the common cold and influenza. Rarely, croup is caused by a bacterial infection. croup infection AE a respiratory system AE that has an outcome of the drawing of a foreign substance into the respiratory tract during inhalation DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/aspiration 10003504 aspiration AE CTCAE:E13310 HPO: HP_0002835 NCIt:C15631 SIDER: C0700198 a respiratory system AE that has an outcome of the removal of gas or fluid from the pleural cavity of the lungs DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/aspiration 10003522 aspiration pleural cavity AE a skin adverse event which has an outcome of excoriation AE is an injury to a surface of the body caused by trauma, such as scratching, abrasion, or a chemical or thermal burn. SS, YH WEB: http://medical-dictionary.thefreedictionary.com/excoriation 10049796 excoriation AE a pain AE that has an outcome of facial pain SS, YH WEB: http://www.bettermedicine.com/article/facial-pain 10016059 facial pain is a pain in facial area (eyes, eyebrows, forehead, nose, cheeks, mouth, teeth and chin). Facial pain may include injuries to the nerves or bones that coordinate many of your face’s actions. facial pain AE CTCAE: E11094 HPO: HP_0100661 NCIt: C79594 SIDER: C0015468 a hematology investigation result abnormal AE that has an outcome of abnormal full blood count SS, YH, EB 10017412 10064198 full blood count abnormal AE a reflexes decreased AE that has an outcome of hyporeflexia SS, YH WEB: http://en.wikipedia.org/wiki/Hyporeflexia 10021089 Obsoleted because of duplication hyporeflexia is the condition of below normal or absent reflexes. Hyporeflexia is generally associated with a lower motor neuron deficit (at the alpha motor neurons from the spinal cord to muscle). obsolete: hyporeflexia AE HPO: HP_0009072 SIDER: C0151888 a tumor AE that is characterized by cancer in the brain DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/astrocytoma 10003571 astrocytoma AE HPO: HP_0009592 SIDER: C0004114 a medical intervention that uses incorrect dose SS, YH 10064355 incorrect dose administration a lung disorder AE that has an outcome of collapse in part of or all of a lung DJ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001130/ 10003598 atelectasis AE CTCAE:E13316 HPO: HP_0001642 NCIt:C2888 SIDER: C0004144 an influenza serology positive AE that has an outcome of positive result in an influenza virus test SS, YH, EB 10070717 influenza virus test positive AE joint range of motion decreased AE is a mobility decreased AE that results in limited or decreased range of joint motion SS, YH, MW 10048706 joint range of motion decreased AE CTCAE: E12435 NCIt: C78403 a muscle spasm AE which has an outcome of laryngospasm, which is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. The condition typically lasts less than 60 seconds, and causes a partial blocking of breathing in, while breathing out remains easier. It may be triggered when the vocal cords or the area of the trachea below the cords detects the entry of water, mucus, blood, or other substance. It is characterized by stridor and or retractions. SS, YH, MW WEB: http://en.wikipedia.org/wiki/Laryngospasm 10023891 laryngospasm AE CTCAE:E13439 HPO: HP_0006511 NCIt:C79609 SIDER: C0023066 a lymphocyte percentage abnormal AE that has an outcome of decreased lymphocyte percentage SS, YH, EB 10052231 lymphocyte percentage decreased AE a monocyte percentage abnormal AE that has an outcome of increased monocyte percentage SS, YH, EB 10052230 monocyte percentage increased AE a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the brain SS, YH 10029818 nuclear magnetic resonance imaging brain abnormal AE periorbial edema AE is an edema AE that has an outcome of swelling around the eye. MedDRA: 10034545 is for "periorbital edema"; MedDRA: 10054541 is for "periorbital oedema" SS, YH periorbital oedema AE periorbital puffiness WEB: http://en.wikipedia.org/wiki/Periorbital_puffiness Periorbital puffiness, also known as "puffy eyes" or swelling around the eyes, refers to the appearance of swelling in the tissues around the eyes, called the orbits. periorbital edema AE CTCAE: E13676 NCIt: C78530 UMLS CUI: C0151205 a physical quality of a process that shows a positive result of a pregnancy test. SS, YH 10036556 10036575 pregnancy test positive a blood magnesium abnormal AE that has an outcome of an abnormally high concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors. YH, MW WEB: http://emedicine.medscape.com/article/246489-overview 10020670 hypermagnesemia AE CTCAE: E12288 NCIt: C37969 UMLS CUI: C0151714 a sensory capability AE that has an outcome of a sensation feeling of foreign body SS, YH 10061549 sensation of foreign body AE a sensory capability AE that has an outcome of a sensation feeling of heaviness SS, YH feeling heavy AE sensation of heaviness AE a sensory capability AE that has an outcome of a loss of sensation SS, YH 10040030 sensory loss AE HPO: HP_0003474 SIDER: C0278134 a skin adverse event that has an outcome of skin exfoliation SS, YH 10040844 skin exfoliation AE HPO: HP_0007549 SIDER: C0237849 a digestive system AE which has an outcome of stomach discomfort SS, YH stomach upset AE 胃部不适 10042124 stomach discomfort AE an immunology and allergy investigation result abnormal AE that has an outcome of autoantibodies present DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/autoantibody 10060973 autoantibody positive AE a wheezing AE which has an outcome of stridor, a high pitched wheezing sound resulting from turbulent air flow in the upper airway. It is primarily inspiratory. It can be indicative of serious airway obstruction from severe conditions such as epiglottitis, a foreign body lodged in the airway, or a laryngeal tumor. SS, YH, MW WEB: http://en.wikipedia.org/wiki/Stridor 10042241 stridor AE CTCAE:E13579 HPO: HP_0010307 NCIt:C78632 SIDER: C0038450 a skin AE that shows a result of skin ulcer, i.e., a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. SS, YH, MW skin ulcer AE WEB: http://en.wikipedia.org/wiki/Ulcer_%28dermatology%29 10040943 10040947 skin ulceration AE CTCAE: E13730 HPO: HP_0200042 NCIt: C54247 SIDER: C0037299 an incorrect dose administration that uses underdose SS, YH underdose adminstration in medical intervention a respiratory tract congestion AE which has an outcome of upper respiratory tract congestion SS, YH upper respiratory tract congestion AE a urinary system investigation result abnormal AE that has an outcome of a urine analysis abnormality SS, YH, EB 10062226 urine analysis result abnormal AE a urine analysis result abnomal AE that shows ketone body present in urine SS, YH, EB, QL 10057597 urine ketone body present AE a liver/biliary system AE that has an outcome of inflammation of the liver that occurs when immune cells mistake the liver's normal cells for harmful invaders and attack them DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001291/ 10003827 autoimmune hepatitis AE HPO: HP_0004787 SIDER: C0241910 a hemorrhage AE that has an outcome of vaginal hemorrhage MedDRA: 10046910 is for "vaginal haemorrhage"; MedDRA: 10046912 is for "vaginal hemorrhage" SS, YH, MW vaginal haemorrhage AE WEB: http://www.brooksidepress.org/Products/Military_OBGYN/Textbook/AbnormalBleeding/Bleeding.htm vaginal hemorrhage is irregular/heavy bleeding from the vagina. Vaginal hemorrhage is more often associated with pregnancy complications such as miscarriage or placental abruption, but certainly can occur in the absence of pregnancy. vaginal hemorrhage AE CTCAE: E13264 NCIt: C26945 SS, YH WEB: http://en.wikipedia.org/wiki/Vasodilation a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. vasodilatation AE HPO: HP_0004927 SIDER: C0595862 a bacterial infection AE that has an outcome of bacteria in the blood DJ, SS, YH bacteraemia AE WEB: http://medical-dictionary.thefreedictionary.com/bacteremia 10003997 bacteremia AE a sepsis AE caused by bacterial infection in the bloodstream or body tissues DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sepsis 10053840 bacterial sepsis AE a skin AE that has an outcome of a slow-growing nonmelanoma skin cancer DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001827/ 10004146 basal cell carcinoma AE HPO: HP_0002671 SIDER: C0007117 a basophil count abnormal AE that is characterized by increase in the number of basophils in the body DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/basophil+granulocyte 10004169 basophil count increased AE an ulcer AE that is characterized by ulcers in the mouth that may decrease ocular functionality DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/behcet's+disease 10004213 behcet's syndrome AE a musculoskeletal system AE that has an outcome of low muscle tone DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hypotonia 10051900 benign congenital hypotonia AE a female reproductive system AE that has an outcome of a non-fertilized egg that implants itself in the uterus and turns a normal pregnancy into an abnormal one DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hydatidiform+mole 10004272 benign hydatidiform mole AE a benign tumor AE that has an outcome of a benign tumor in their ovaries DJ, SS, YH benign ovarian tumour AE 10004433 benign ovarian tumor AE a digestive system AE that has an outcome of a blockage in the tubes that carry bile from the liber to the gallbladder and small intestine DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000263.htm 10056375 bile duct obstruction AE a liver/biliary system AE that has an outcome of dilating or stretching of the bile duct DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21843715 10057202 biliary dilatation AE an eating disorder that is characterized by episodes of uncontrollable eating. DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/binge+eating 10004716 binge eating AE an eye disorder AE that has an outcome of binocular eye movement disorder where control and alignment of eyes are compromised DJ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/23201436 Secondary Source: http://brain.oxfordjournals.org/content/119/6/1933.full.pdf 10061010 binocular eye movement disorder AE a digestive system AE that has an outcome of cancer that starts in the bladder, the body part that holds and releases urine in the center of the lower belly area DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001517/ 10005003 bladder cancer AE HPO: HP_0009725 SIDER: C0005684 a blast cell count abnormal AE that has an outcome of an increased amount of immature precursors of either lymphocytes or granulocytes that do not normally appear in peripheral blood. May indicate acute leukemia DJ, SS, YH WEB: http://meds.queensu.ca/medicine/deptmed/hemonc/anemia/blast.htm 10062274 blast cell count increased AE a hematopoietic system AE that has an outcome of a sudden, severe change in the course of chronic granulocytic leukemia with an increase in the proportion of myeloblasts DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/blast+crisis 10053747 blast cell crisis AE a hematopoietic system AE that has an outcome of myeloblasts or myeloid blasts. Presence of these abnormal blasts prevent production of adequate platelets, red blood cells and white blood cells, can be associated with leukemia DJ, SS, YH WEB: http://lymphoma.about.com/od/glossary/ss/Blast-Cells.htm 10057107 blast cells present AE a hematopoietic system AE that has an outcome of the last stage of chronic myelogenous leukemia characterized by rapid progression and short survival with an increase of myeloblasts or lymphoblasts in the blood or bone marrow DJ, SS, YH blast crisis in myelogenous leukaemia AE WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/blast+crisis , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23171293 10050282 blast crisis in myelogenous leukemia AE an eye inflammation AE that has an outcome of swelling in the eyelids, usually where eyelash follicles are located DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002586/ 10005148 blepharitis AE HPO: HP_0000498 SIDER: C0005741 a blood albumin level abnormal AE with an outcome of a decrease in the amount of albumin, a protein made by the liver DJ, SS, YH, EB hypoalbuminemia AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003480.htm 10005287 blood albumin level decreased AE a liver related investigation result abnormal AE that has an outcome of an abnormal level of alkaline phosphatase in the blood DJ, SS, YH, EB 10059571 blood alkaline phosphatase level abnormal AE a blood alkaline phosphatase abnormal AE that has an outcome of a decreased level of alkaline phosphatase in the blood DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase 10059569 blood alkaline phosphatase decreased AE a blood alkaline phosphatase abnormal AE that has an outcome of elevated levels of alkaline phosphatase, an enzyme responsible for removing phosphate groups. a liver/biliary system AE that has an outcome of an increased amount of ALP, an isoenzyme that removes phosphate groups commonly found in the bile ducts but also found in the bone DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase 10001675 10059570 blood alkaline phosphatase increased AE CTCAE: E12082 HPO: HP_0003155 NCIt: C35607 SIDER: C0852911 a distal neuropathy AE which shows a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. It is caused by the loss of myelin sheath of the peripheral nerves. AG, YH CIDP Chronic Inflammatory Demyelinating Polyneuropathy WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm chronic inflammatory demyelinating neuropathy AE a blood amylase level abnormal AE that has an outcome of an increased amount of amylase, an enzyme that helps digest carbohydrates; may indicate disease or inflammation of the pancreas DJ, SS, YH, EB serum amylase increased AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003464.htm 10005328 10040139 blood amylase level increased AE CTCAE: E12212 NCIt: C78608 a liver related investigation result abnormal AE that has an outcome of an abnormal amount of bilirubin in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/bilirubin 10058477 blood bilirubin level abnormal AE a blood bilirubin level abnormal AE with an outcome of a increased amount of bilirubin, or a yellow breakdown product (broken down hemoglobin) of normal heme catabolism, in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/bilirubin 10005364 blood bilirubin level increased AE CTCAE: E12096 NCIt: C27088 a physical quality that has a decreased amount of calcium in the bloodstream DJ, SS, YH 10005395 blood calcium decreased A physical quality that has an decreased level of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease DJ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=9940 10005419 blood chloride decreased HPO: HP_0003113 SIDER: C0595902 a blood cholesterol abnormal AE with the result of an increase in cholesterol level in the blood DJ, SS, YH, EB 10005425 blood cholesterol increased AE CTCAE: E12127 HPO: HP_0003124 NCIt: C37967 SIDER: C0595930 an enzyme investigation result abnormal AE that has an outcome of abnormal levels of creatine phosphokinase in the blood DJ, SS, YH, EB 10005468 blood creatine phosphokinase level abnormal AE a blood creatinine level abnormal AE that has an outcome of an increased level of creatinine in the blood (due to lack of kidney activity) DJ, SS, YH, EB creatinine increased AE serum creatinine increased WEB: http://medical-dictionary.thefreedictionary.com/creatinine 10005483 10011368 blood creatinine level increased AE CTCAE: E12137 NCIt: C78249 an infection adverse event that has an outcome of bacteria or yeasts in the blood DJ, SS, YH WEB: http://labtestsonline.org/understanding/analytes/blood-culture/tab/test 10005488 blood culture positive AE