OAE: Ontology of Adverse Events
type: Ontology
editor note: Product version
contributor: Darrell R. Abernethy
contributor: Elizabeth Blair
contributor: Izabela Birsanescu
contributor: Keith Burkhart
contributor: Luca Toldo
contributor: Mathias Brochhausen
contributor: Sydni Joubran
creator: "Asiyah" Yu Lin
creator: Abra Guo
creator: Barry Smith
creator: Bingjian Yang
creator: David Ameriguian
creator: Desikan Jagannathan
creator: Edison Ong
creator: Jessica DeGuise
creator: Jiangan "Hardy" Xie
creator: Jiangan Xie
creator: Kelly Yang
creator: Kevin Mo
creator: Ling Wan
creator: Liwei Wang
creator: Meiu Wong
creator: Noemi Garg
creator: Qingping Liu
creator: Qiuyue Yang
creator: Rebecca Racz
creator: Shelley Zhang
creator: Sirarat Sarntivijai
creator: Sydni Joubran
creator: Yongqun "Oliver" He (YH)
creator: Zuoshuang "Allen" Xiang
date: 2022-8-15
description: The Ontology of Adverse Eventsy (OAE) is a biomedical ontology in the domain of adverse events. OAE aims to standardize adverse event annotation, integrate various adverse event data, and support computer-assisted reasoning. OAE is a community-based ontology. Its development follows the OBO Foundry principles. Vaccine adverse events have been used as an initial testing use case. OAE also studies adverse events associated with the administration of drug and nutritional products, the operation of surgeries, and the usage of medical devices, etc.
format: OWL-DL
license: http://creativecommons.org/licenses/by/3.0/
subject: An ontology for the annotation of the adverse event domain.
version info: 1.2.47

BFO OWL specification label
type: AnnotationProperty
definition: Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
curator note: Really of interest to developers only
sub property of: label

BFO CLIF specification label
type: AnnotationProperty
definition: Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
definition source: Person:Alan Ruttenberg
curator note: Really of interest to developers only
sub property of: label

editor preferred label
type: AnnotationProperty
editor preferred label: editor preferred label
editor preferred label: editor preferred term
editor preferred label: editor preferred term~editor preferred label
has curation status: IAO_0000122
definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: editor preferred term
label: editor preferred term~editor preferred label

example of usage
type: AnnotationProperty
editor preferred label: example
has curation status: IAO_0000122
definition: A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

has curation status
type: AnnotationProperty
editor preferred label: has curation status
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bill Bug
definition editor: PERSON:Melanie Courtot
definition source: OBI_0000281

definition
type: AnnotationProperty
editor preferred label: definition
editor preferred label: textual definition
has curation status: IAO_0000122
definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: textual definition

editor note
type: AnnotationProperty
editor preferred label: editor note
has curation status: IAO_0000122
definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
database_cross_reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: 1
shorthand: editor_note

definition editor
type: AnnotationProperty
editor preferred label: term editor
has curation status: IAO_0000122
definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: term editor

alternative term
type: AnnotationProperty
editor preferred label: alternative term
has curation status: IAO_0000125
definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

definition source
type: AnnotationProperty
editor preferred label: definition source
has curation status: IAO_0000122
definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

curator note
type: AnnotationProperty
editor preferred label: curator note
has curation status: IAO_0000122
definition: An administrative note of use for a curator but of no use for a user
definition editor: PERSON:Alan Ruttenberg
database_cross_reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: 1
shorthand: curator_notes
label: curator notes

imported from
type: AnnotationProperty
editor preferred label: imported from
has curation status: IAO_0000125
definition: For external terms/classes, the ontology from which the term was imported
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

expand expression to
type: AnnotationProperty

expand assertion to
type: AnnotationProperty

elucidation
type: AnnotationProperty
editor preferred label: elucidation
definition editor: person:Alan Ruttenberg
definition source: Person:Barry Smith
elucidation: Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms

has associated axiom(nl)
type: AnnotationProperty
editor preferred label: has associated axiom(nl)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom associated with a term expressed using natural language

has associated axiom(fol)
type: AnnotationProperty
editor preferred label: has associated axiom(fol)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom expressed in first order logic using CLIF syntax

has axiom label
type: AnnotationProperty

Chinese translation
type: AnnotationProperty
definition editor: YH, JX
comment: a chinese translation represents a chinese translation of the existing term.

adverse event outcome
type: AnnotationProperty
example of usage: The AE 'cough AE' has the 'label of AE outcome' of 'cough'; 'infection AE' has the 'label of AE outcom' of 'infection'.
definition: an annotation property that represents the label of an adverse event
definition editor: Yongqun Oliver He, Jiangan Hardy Xie
alternative term: label of adverse event outcome
sub property of: label

has_MedDRA_id
type: AnnotationProperty

has_specified_input
type: AnnotationProperty
type: ObjectProperty
sub property of: has participant
imported from: obi.owl
definition editor: PERSON: Alan Ruttenberg
editor note: 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works.
example of usage: see is_input_of example_of_usage
definition editor: PERSON: Melanie Coutot
definition editor: PERSON: Larry Hunter
definition: A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
has curation status: IAO_0000122
editor preferred label: has_specified_input
definition editor: PERSON: Bjoern Peters

has_specified_output
type: AnnotationProperty
type: ObjectProperty
sub property of: has participant
editor preferred label: has_specified_output
definition editor: PERSON: Melanie Courtot
definition editor: PERSON: Bjoern Peters
definition: A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
imported from: obi.owl
definition editor: PERSON: Alan Ruttenberg
has curation status: IAO_0000122
definition editor: PERSON: Larry Hunter

temporal interpretation
type: AnnotationProperty
definition: An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.
sub property of: logical macro assertion on an object property

never in taxon
type: AnnotationProperty
example of usage: tooth SubClassOf 'never in taxon' value 'Aves'
definition: x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
expand assertion to: ?X DisjointWith RO_0002162 some ?Y
sub property of: taxonomic class assertion

taxonomic class assertion
type: AnnotationProperty
definition: An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon.
sub property of: logical macro assertion on a class

dubious_for_taxon
type: AnnotationProperty
definition: S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
database_cross_reference: RO:0002174
has_obo_namespace: uberon
id: dubious_for_taxon
is class level: 1
is metadata tag: 1
shorthand: dubious_for_taxon
comment: this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost

present_in_taxon
type: AnnotationProperty
definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
database_cross_reference: RO:0002175
has_exact_synonym: applicable for taxon
has_obo_namespace: uberon
id: present_in_taxon
is class level: 1
is metadata tag: 1
shorthand: present_in_taxon

logical macro assertion
type: AnnotationProperty
definition: An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL.

logical macro assertion on a class
type: AnnotationProperty
definition: A logical macro assertion whose domain is an IRI for a class
editor note: The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL
sub property of: logical macro assertion

logical macro assertion on a property
type: AnnotationProperty
definition: A logical macro assertion whose domain is an IRI for a property
sub property of: logical macro assertion

logical macro assertion on an object property
type: AnnotationProperty
sub property of: logical macro assertion on a property

logical macro assertion on an annotation property
type: AnnotationProperty
sub property of: logical macro assertion on a property

is direct form of
type: AnnotationProperty
definition: relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y
logical macro assertion on an annotation property: If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'
creator: Chris Mungall
sub property of: logical macro assertion on an object property

external_definition
type: AnnotationProperty
definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: UBPROP:0000001
has_obo_namespace: uberon
id: external_definition
is metadata tag: 1
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

axiom_lost_from_external_ontology
type: AnnotationProperty
definition: A textual description of an axiom loss in this ontology compared to an external ontology.
database_cross_reference: UBPROP:0000002
has_obo_namespace: uberon
id: axiom_lost_from_external_ontology
is metadata tag: 1
shorthand: axiom_lost_from_external_ontology
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

homology_notes
type: AnnotationProperty
definition: Notes on the homology status of this class.
database_cross_reference: UBPROP:0000003
has_obo_namespace: uberon
id: homology_notes
is metadata tag: 1
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

external_comment
type: AnnotationProperty
definition: An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info.
database_cross_reference: UBPROP:0000005
has_obo_namespace: uberon
id: external_comment
is metadata tag: 1
shorthand: external_comment
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

implements_design_pattern
type: AnnotationProperty
database_cross_reference: UBPROP:0000006
has_obo_namespace: uberon
id: implements_design_pattern
is metadata tag: 1
shorthand: implements_design_pattern

has_relational_adjective
type: AnnotationProperty
curator note: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
database_cross_reference: UBPROP:0000007
has_obo_namespace: uberon
id: has_relational_adjective
is metadata tag: 1
shorthand: has_relational_adjective

taxon_notes
type: AnnotationProperty
definition: Notes on the how instances of this class vary across species.
database_cross_reference: UBPROP:0000008
has_obo_namespace: uberon
id: taxon_notes
is metadata tag: 1
shorthand: taxon_notes

function_notes
type: AnnotationProperty
definition: Notes on the evolved function of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000009
has_obo_namespace: uberon
id: function_notes
is metadata tag: 1
shorthand: function_notes

structure_notes
type: AnnotationProperty
definition: Notes on the structure, composition or histology of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000010
has_obo_namespace: uberon
id: structure_notes
is metadata tag: 1
shorthand: structure_notes

development_notes
type: AnnotationProperty
definition: Notes on the ontogenic development of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000011
has_obo_namespace: uberon
id: development_notes
is metadata tag: 1
shorthand: development_notes

external_ontology_notes
type: AnnotationProperty
definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000012
has_obo_namespace: uberon
id: external_ontology_notes
is metadata tag: 1
shorthand: external_ontology_notes

terminology_notes
type: AnnotationProperty
definition: Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000013
has_obo_namespace: uberon
id: terminology_notes
is metadata tag: 1
shorthand: terminology_notes

is count of
type: AnnotationProperty
database_cross_reference: UBPROP:0000100
has_obo_namespace: uberon
id: is_count_of
is metadata tag: 1
shorthand: is_count_of

preceding element is
type: AnnotationProperty
definition: A property used in conjunction with repeated_element_number to indicate an axis and directionality along that axis. If P preceding_element_is R, and P is_count_of S, and X P N, and X' P N+1, then it follows that every X R some X', and the class expression [S and R some X' and inv(R) some X] is empty (i.e. X is followed by X', with no intermediates)
database_cross_reference: UBPROP:0000101
has_obo_namespace: uberon
id: preceding_element_is
is metadata tag: 1
shorthand: preceding_element_is

pharyngeal arch number
type: AnnotationProperty
definition: x pharyngeal_arch_number N if and only if (i) x is a pharyngeal arch, and (ii) x is ancestrally pharyngeal arch number N in a series of pharyngeal arches repeated along a antero-posterior axis, with arch_number 1 being the mandibular arch.
terminology_notes: gill arch N = PA N-2. the term branchial_arch is ambiguous.
is count of: UBERON_0002539
preceding element is: anterior_to
database_cross_reference: UBPROP:0000103
has_obo_namespace: uberon
id: pharyngeal_arch_number
is metadata tag: 1
shorthand: pharyngeal_arch_number

phalanx number
type: AnnotationProperty
definition: x phalanx_number N if and only if (i) x is a phalanx, and (ii) x is phalanx number N in a series of phalanges repeated along an prixomo-distal axis, with phalanx_number 1 being the proximalmost phalanx. Note that in humans, the distalmost phalanx has phlanax_number 3, except in ray_number 1, where the distalmost has phalanx_number 2
is count of: UBERON_0003221
preceding element is: proximal_to
database_cross_reference: UBPROP:0000105
has_obo_namespace: uberon
id: phalanx_number
is metadata tag: 1
shorthand: phalanx_number
comment: Most land mammals including humans have a 2-3-3-3-3 formula in both the hands (or paws) and feet. Primitive reptiles typically had the formula 2-3-4-4-5, and this pattern, with some modification, remained in many later reptiles and in the mammal-like reptiles. The phalangeal formula in the flippers of cetaceans (marine mammals) is 2-12-8-1

fma_set_term
type: AnnotationProperty
external_ontology_notes: FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term
database_cross_reference: UBPROP:0000202
has_obo_namespace: uberon
id: fma_set_term
is metadata tag: 1
shorthand: fma_set_term

eco subset
type: AnnotationProperty
sub property of: subset_property

cumbo
type: AnnotationProperty
comment: CUMBO
sub property of: subset_property

developmental classification
type: AnnotationProperty
comment: developmental_classification
sub property of: subset_property

early development
type: AnnotationProperty
comment: A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes.
sub property of: subset_property

efo slim
type: AnnotationProperty
comment: EFO slim
sub property of: subset_property

emapa ehdaa2
type: AnnotationProperty
comment: derived from the union of EHDAA2 and EMAPA - still to be checked
sub property of: subset_property

functional classification
type: AnnotationProperty
comment: functional_classification
sub property of: subset_property

grouping class
type: AnnotationProperty
comment: Subset consisting of classes creating for grouping purposes
sub property of: subset_property

homology grouping
type: AnnotationProperty
comment: A grouping class that depends on an assumption of homology between subclasses
sub property of: subset_property

inconsistent with fma
type: AnnotationProperty
comment: classes that have some inconsistency with FMA
sub property of: subset_property

major organ
type: AnnotationProperty
comment: somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads
sub property of: subset_property

non informative
type: AnnotationProperty
comment: abstract class brought in to group ontology classes but not informative
sub property of: subset_property

organ slim
type: AnnotationProperty
comment: organs, excluding individual muscles and skeletal elements
sub property of: subset_property

pheno slim
type: AnnotationProperty
comment: Phenotype slim
sub property of: subset_property

uberon slim
type: AnnotationProperty
comment: Uberon slim - subset that excludes obscure terms and deep compositional terms
sub property of: subset_property

upper level
type: AnnotationProperty
comment: abstract upper-level terms not directly useful for analysis
sub property of: subset_property

vertebrate core
type: AnnotationProperty
comment: core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO
sub property of: subset_property

contributor
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: 1
shorthand: dc-contributor

Description
type: AnnotationProperty
description: Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content.
comment: An account of the content of the resource.

Source
type: AnnotationProperty
description: The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system.
comment: A reference to a resource from which the present resource is derived.

subset_property
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

label
type: AnnotationProperty
editor preferred label: label

depicted_by
type: AnnotationProperty
has_obo_namespace: uberon
id: foaf-depicted_by
is metadata tag: 1
shorthand: foaf-depicted_by

part of
type: ObjectProperty
sub property of: overlaps
inverse of: has part
type: TransitiveProperty
editor preferred label: is part of
example of usage: my brain is part of my body (continuant parthood, two material entities)
example of usage: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
example of usage: this day is part of this year (occurrent parthood)
definition: a core relation that holds between a part and its whole
editor note: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: part_of
imported from: go.owl
imported from: ro.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: BFO:0000050
has_obo_namespace: uberon
id: part_of
shorthand: part_of

has part
type: ObjectProperty
sub property of: overlaps
sub property of: has material contribution from
type: TransitiveProperty
editor preferred label: has part
example of usage: my body has part my brain (continuant parthood, two material entities)
example of usage: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
example of usage: this year has part this day (occurrent parthood)
definition: a core relation that holds between a whole and its part
editor note: Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: has_part
imported from: ro.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: BFO:0000051
has_obo_namespace: uberon
id: has_part
shorthand: has_part

realized in
type: ObjectProperty
inverse of: realizes
domain: realizable entity
range: process
editor preferred label: realized in
example of usage: this disease is realized in this disease course
example of usage: this fragility is realized in this shattering
example of usage: this investigator role is realized in this investigation
alternative term: is realized by
alternative term: realized_in
imported from: obi.owl
imported from: ro.owl
elucidation: [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

realizes
type: ObjectProperty
domain: process
range: realizable entity
editor preferred label: realizes
example of usage: this disease course realizes this disease
example of usage: this investigation realizes this investigator role
example of usage: this shattering realizes this fragility
imported from: obi.owl
imported from: ro.owl
elucidation: to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

preceded_by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: starts during
property chain axiom: happens during
editor preferred label: preceded by
definition: X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)
definition: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
editor note: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
alternative term: is preceded by
alternative term: preceded_by
imported from: ro.owl
imported from: uberon.owl
Source: http://www.obofoundry.org/ro/#OBO_REL:preceded_by
database_cross_reference: BFO:0000062
has_exact_synonym: is preceded by
has_exact_synonym: takes place after
has_obo_namespace: uberon
id: preceded_by
in_subset: eco subset
shorthand: preceded_by
label: preceded by

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: happens during
editor preferred label: precedes
definition: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: BFO:0000063
has_obo_namespace: uberon
id: precedes
in_subset: eco subset
shorthand: precedes

occurs in
type: ObjectProperty
inverse of: contains process
domain: occurrent
range: independent continuant
property chain axiom: part of
editor preferred label: occurs in
definition: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
alternative term: occurs_in
alternative term: unfolds in
alternative term: unfolds_in
imported from: go.owl
imported from: ro.owl
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant

contains process
type: ObjectProperty
editor preferred label: site of
definition: [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
imported from: ro.owl
comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant

anterior_to
type: ObjectProperty
type: TransitiveProperty
definition: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer
imported from: uberon.owl
created by: cjm
creation date: 2009-07-31T02:15:46Z
database_cross_reference: BSPO:0000096
has_obo_namespace: uberon
id: anterior_to
shorthand: anterior_to

distal_to
type: ObjectProperty
definition: x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal).
imported from: uberon.owl
database_cross_reference: BSPO:0000097
has_obo_namespace: uberon
id: distal_to
shorthand: distal_to

dorsal_to
type: ObjectProperty
inverse of: ventral_to
type: TransitiveProperty
definition: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
imported from: uberon.owl
database_cross_reference: BSPO:0000098
has_obo_namespace: uberon
id: dorsal_to
shorthand: dorsal_to

posterior_to
type: ObjectProperty
type: TransitiveProperty
definition: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail.
imported from: uberon.owl
database_cross_reference: BSPO:0000099
has_narrow_synonym: caudal_to
has_obo_namespace: uberon
id: posterior_to
shorthand: posterior_to

proximal_to
type: ObjectProperty
definition: x proximal_to y iff x is closer to the point of attachment with the body than y.
imported from: uberon.owl
database_cross_reference: BSPO:0000100
has_obo_namespace: uberon
id: proximal_to
shorthand: proximal_to

ventral_to
type: ObjectProperty
type: TransitiveProperty
definition: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
imported from: uberon.owl
database_cross_reference: BSPO:0000102
has_obo_namespace: uberon
id: ventral_to
shorthand: ventral_to

deep_to
type: ObjectProperty
type: TransitiveProperty
definition: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
imported from: uberon.owl
database_cross_reference: BSPO:0000107
has_obo_namespace: uberon
id: deep_to
shorthand: deep_to

superficial_to
type: ObjectProperty
definition: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
imported from: uberon.owl
database_cross_reference: BSPO:0000108
has_obo_namespace: uberon
id: superficial_to
shorthand: superficial_to

in_left_side_of
type: ObjectProperty
sub property of: in_lateral_side_of
definition: X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion.
imported from: uberon.owl
database_cross_reference: BSPO:0000120
has_obo_namespace: uberon
id: in_left_side_of
shorthand: in_left_side_of

in_right_side_of
type: ObjectProperty
sub property of: in_lateral_side_of
definition: X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion.
imported from: uberon.owl
database_cross_reference: BSPO:0000121
has_obo_namespace: uberon
id: in_right_side_of
shorthand: in_right_side_of

in_posterior_side_of
type: ObjectProperty
sub property of: part of
definition: X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion.
imported from: uberon.owl
database_cross_reference: BSPO:0000122
has_obo_namespace: uberon
id: in_posterior_side_of
shorthand: in_posterior_side_of

in_anterior_side_of
type: ObjectProperty
sub property of: part of
definition: X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion.
imported from: uberon.owl
database_cross_reference: BSPO:0000123
has_obo_namespace: uberon
id: in_anterior_side_of
shorthand: in_anterior_side_of

in_proximal_side_of
type: ObjectProperty
sub property of: part of
inverse of: in_distal_side_of
definition: X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion.
imported from: uberon.owl
database_cross_reference: BSPO:0000124
has_obo_namespace: uberon
id: in_proximal_side_of
shorthand: in_proximal_side_of

in_distal_side_of
type: ObjectProperty
sub property of: part of
definition: X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion.
imported from: uberon.owl
database_cross_reference: BSPO:0000125
has_obo_namespace: uberon
id: in_distal_side_of
shorthand: in_distal_side_of

in_lateral_side_of
type: ObjectProperty
sub property of: part of
property disjoint with: in_central_side_of
definition: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
imported from: uberon.owl
database_cross_reference: BSPO:0000126
has_obo_namespace: uberon
id: in_lateral_side_of
shorthand: in_lateral_side_of

proximalmost_part_of
type: ObjectProperty
sub property of: in_proximal_side_of
definition: X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y
imported from: uberon.owl
database_cross_reference: BSPO:0001106
has_obo_namespace: uberon
id: proximalmost_part_of
shorthand: proximalmost_part_of

distalmost_part_of
type: ObjectProperty
sub property of: in_distal_side_of
definition: X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y
imported from: uberon.owl
database_cross_reference: BSPO:0001108
has_obo_namespace: uberon
id: distalmost_part_of
shorthand: distalmost_part_of

induced_by
type: ObjectProperty
sub property of: preceded_by
definition: a preceded_by relation that indicates that one process (e.g., an adverse event) is causally preceded by (induced by) another process (e.g., a medical intervention) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes.
definition editor: Yongqun He
alternative term: induced by

induces
type: ObjectProperty
definition: the relation indicates that one process (e.g., a medical intervention) induces another process (e.g., an adverse event) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. This is an inverse relation of the term "induced_by".
creator: YH, AG

role_of
type: ObjectProperty
comment: This is a tentative relation. We need to get this role from another ontology later. Oliver -- BFO 2.0 has this role 'is role of':: http://purl.obolibrary.org/obo/BFO_0000081 Once we get BFO 2.0, we can replace with this role. Oliver

is evidence of
type: ObjectProperty
example of usage: An electrocardiogram qt prolonged AE is_evidence_of arrhythmia AE; arrhythmia AE is_evidence_of cardiomyopathy AE; fever AE is_evidence_of inflammation AE; fever AE is_evidence_of viral infection AE; plural effusion AE is_evidence_of cardiac disorder AE.
definition: AE1 is_evidence_of AE2 if and only if: given an adverse event instance ae1 that instantiates class AE1 (e.g., electrocardiogram qt prolonged AE) and another adverse event instance ae2 that instantiates class AE2 (e.g., arrhythmia AE), both ae1 and ae2 are adverse events that are clinically observed after a medical intervention (at time t0) on the same patient. The presence of ae1 is supported by priori knowledge of medicine to imply the presence of ae2 with some probability P (P is NOT always 1, thus transitivity does not apply to is_evidence_of relation. AE1 is_evidence_of AE2 and AE2 is_evidence_of AE3 DOES NOT imply AE1 is_evidence_of AE3). The instance ae1 and ae2 are observed or detected at time t1 and t2, respectively. The biological onset time for ae1 or ae2 may occur before t1 or t2. The t1 and t2 can be the same time point or different time points.
editor note: This represents a relation between two adverse events AE1 and AE2. However, AE1 may be an evidence of another adverse event AE3, and a dfferent adverse event AE4 may also be an evidence of the same AE2.
definition editor: SS, YH, YL

has participant quality
type: ObjectProperty
example of usage: An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased.
definition: an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality.
editor note: This is a shortcut relation of the following full version: 'has participant' some (participant 'has quality' ) in: process 'has participant' some (participant 'has quality' some quality)
definition editor: Yongqun He

AE occurs in
type: ObjectProperty
sub property of: occurs in
definition: a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in.
definition editor: Yongqun He
alternative term: adverse event occurs in

has participant undergoing
type: ObjectProperty
sub property of: topObjectProperty
definition: A shortcut relation that represents the full path of ‘has participant’ some participant that ‘participates in’ some process.
definition editor: Yongqun He

adverse event preceded by
type: ObjectProperty
sub property of: preceded_by
domain: adverse event
definition: a specific 'preceded by' object property that has a domain of an adverse event.
definition editor: Yongqun He

bearer of
type: ObjectProperty
range: specifically dependent continuant
editor preferred label: bearer of
example of usage: this apple is bearer of this red color
example of usage: this vase is bearer of this fragility
definition: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
editor note: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
alternative term: bearer_of
alternative term: is bearer of
imported from: ro.owl
temporal interpretation: RO_0001901

has participant
type: ObjectProperty
editor preferred label: has participant
example of usage: this blood coagulation has participant this blood clot
example of usage: this investigation has participant this investigator
example of usage: this process has participant this input material (or this output material)
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
editor note: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
alternative term: has_participant
imported from: obi.owl
Source: http://www.obofoundry.org/ro/#OBO_REL:has_participant

has quality
type: ObjectProperty
sub property of: bearer of
range: quality
example of usage: this apple has quality this red color
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
editor note: A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
alternative term: has_quality
imported from: ro.owl

has role
type: ObjectProperty
sub property of: bearer of
domain: independent continuant
range: role
example of usage: this person has role this investigator role (more colloquially: this person has this role of investigator)
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
editor note: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
alternative term: has_role
imported from: ro.owl

location_of
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0001015
has_obo_namespace: uberon
id: location_of
shorthand: location_of

located_in
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0001025
has_obo_namespace: uberon
id: located_in
shorthand: located_in

has boundary
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0002002
has_obo_namespace: uberon
id: has_boundary
shorthand: has_boundary

innervated_by
type: ObjectProperty
inverse of: innervates
property chain axiom: branching_part_of
imported from: uberon.owl
has_alternative_id: FMA:85999
has_alternative_id: dbprop:nerve
database_cross_reference: RO:0002005
has_exact_synonym: nerve supply
has_obo_namespace: uberon
id: innervated_by
shorthand: innervated_by
comment: http://code.google.com/p/obo-relations/issues/detail

bounding layer of
type: ObjectProperty
sub property of: part of
imported from: uberon.owl
database_cross_reference: RO:0002007
has_obo_namespace: uberon
id: bounding_layer_of
shorthand: bounding_layer_of
comment: A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.

before or simultaneous with
type: ObjectProperty
sub property of: temporally related to
definition editor: David Osumi-Sutherland
alternative term: <=
imported from: ro.owl
in_subset: eco subset
comment: Primitive instance level timing relation between events

simultaneous_with
type: ObjectProperty
sub property of: before or simultaneous with
sub property of: starts
sub property of: ends
type: TransitiveProperty
definition: Relation between occurrents, shares start and end boundaries.
definition editor: David Osumi-Sutherland
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002082
has_exact_synonym: coincides_with
has_exact_synonym: is_equal_to
has_obo_namespace: uberon
id: simultaneous_with
in_subset: eco subset
shorthand: simultaneous_with
comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
label: simultaneous with

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
property chain axiom: ends during
property chain axiom: preceded_by
definition editor: David Osumi-Sutherland
imported from: ro.owl
in_subset: eco subset
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)

immediately_preceded_by
type: ObjectProperty
sub property of: preceded_by
inverse of: immediately precedes
property chain axiom: starts with
property chain axiom: ends with
definition: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
definition editor: David Osumi-Sutherland
alternative term: starts_at_end_of
imported from: ro.owl
imported from: uberon.owl
external_definition: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
database_cross_reference: RO:0002087
has_exact_synonym: directly preceded by
has_exact_synonym: is directly preceded by
has_exact_synonym: is immediately preceded by
has_exact_synonym: starts_at_end_of
has_obo_namespace: uberon
id: immediately_preceded_by
shorthand: immediately_preceded_by
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
label: immediately preceded by

immediately precedes
type: ObjectProperty
sub property of: precedes
property chain axiom: ends with
property chain axiom: starts with
definition editor: David Osumi-Sutherland
alternative term: ends_at_start_of
alternative term: meets
imported from: ro.owl
is direct form of: precedes
in_subset: eco subset
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)

starts during
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
definition editor: David Osumi-Sutherland
alternative term: io
imported from: ro.owl
in_subset: eco subset
comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
definition editor: David Osumi-Sutherland
alternative term: d
alternative term: during
imported from: ro.owl
in_subset: eco subset
comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

ends during
type: ObjectProperty
sub property of: temporally related to
definition editor: David Osumi-Sutherland
alternative term: o
alternative term: overlaps
imported from: ro.owl
in_subset: eco subset
comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).

overlaps
type: ObjectProperty
sub property of: mereotopologically related to
property chain axiom: part of
property chain axiom: has part
has curation status: IAO_0000125
definition: x overlaps y if and only if there exists some z such that x has part z and z part of y
imported from: ro.owl
imported from: uberon.owl
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
temporal interpretation: RO_0001901
in_subset: eco subset

innervates
type: ObjectProperty
property chain axiom: part of
imported from: uberon.owl
database_cross_reference: RO:0002134
has_obo_namespace: uberon
id: innervates
shorthand: innervates
comment: http://code.google.com/p/obo-relations/issues/detail

continuous_with
type: ObjectProperty
type: SymmetricProperty
imported from: uberon.owl
database_cross_reference: RO:0002150
has_obo_namespace: uberon
id: continuous_with
shorthand: continuous_with

homologous_to
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0002158
has_obo_namespace: uberon
id: homologous_to
shorthand: homologous_to

connected to
type: ObjectProperty
sub property of: transitively_connected to
definition: Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.
imported from: uberon.owl
database_cross_reference: RO:0002170
has_obo_namespace: uberon
id: connected_to
shorthand: connected_to
comment: Connection does not imply overlaps.

connects
type: ObjectProperty
definition: Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.
editor note: this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)
imported from: uberon.owl
database_cross_reference: RO:0002176
has_obo_namespace: uberon
id: connects
shorthand: connects

attaches_to_part_of
type: ObjectProperty
property chain axiom: attaches_to
property chain axiom: part of
imported from: uberon.owl
database_cross_reference: RO:0002177
has_obo_namespace: uberon
id: attaches_to_part_of
shorthand: attaches_to_part_of

supplies
type: ObjectProperty
sub property of: connected to
definition: relation between an artery and the structure is supplies with blood.
imported from: uberon.owl
has_alternative_id: FMA:86003
database_cross_reference: RO:0002178
has_exact_synonym: arterial supply of
has_obo_namespace: uberon
id: supplies
shorthand: supplies
comment: source: FMA

drains
type: ObjectProperty
sub property of: connected to
imported from: uberon.owl
database_cross_reference: RO:0002179
has_exact_synonym: drains blood from
has_exact_synonym: drains from
has_obo_namespace: uberon
id: drains
shorthand: drains
comment: source: Wikipedia

develops_from
type: ObjectProperty
sub property of: has developmental contribution from
sub property of: has material contribution from
inverse of: develops_into
type: TransitiveProperty
property chain axiom: part of
imported from: uberon.owl
database_cross_reference: RO:0002202
has_obo_namespace: uberon
id: develops_from
shorthand: develops_from

develops_into
type: ObjectProperty
sub property of: has potential to develop into
imported from: uberon.owl
database_cross_reference: RO:0002203
has_obo_namespace: uberon
id: develops_into
shorthand: develops_into

surrounded_by
type: ObjectProperty
inverse of: surrounds
definition: x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y
imported from: uberon.owl
database_cross_reference: RO:0002219
has_obo_namespace: uberon
id: surrounded_by
shorthand: surrounded_by

adjacent_to
type: ObjectProperty
type: SymmetricProperty
definition: x adjacent_to y iff: x and y share a boundary
imported from: uberon.owl
database_cross_reference: RO:0002220
has_obo_namespace: uberon
id: adjacent_to
shorthand: adjacent_to

surrounds
type: ObjectProperty
definition: inverse of surrounded_by
imported from: uberon.owl
database_cross_reference: RO:0002221
has_obo_namespace: uberon
id: surrounds
shorthand: surrounds

temporally related to
type: ObjectProperty
domain: occurrent
range: occurrent
has curation status: IAO_0000125
definition editor: Chris Mungall
definition source: Allen's interval algebra
curator note: Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
imported from: ro.owl
Source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
in_subset: eco subset
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

starts
type: ObjectProperty
sub property of: part of
inverse of: starts with
definition: Relation between occurrents, shares a start boundary with.
imported from: uberon.owl
database_cross_reference: RO:0002223
has_obo_namespace: uberon
id: starts
shorthand: starts

starts with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
example of usage: Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor
has curation status: IAO_0000125
definition: x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: Chris Mungall
alternative term: started by
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002224
has_obo_namespace: uberon
id: starts_with
in_subset: eco subset
shorthand: starts_with

ends
type: ObjectProperty
sub property of: part of
definition: Relation between occurrents, shares an end boundary with.
imported from: uberon.owl
database_cross_reference: RO:0002229
has_exact_synonym: finishes
has_obo_namespace: uberon
id: ends
shorthand: ends

ends with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
has curation status: IAO_0000125
definition: x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: Chris Mungall
alternative term: finished by
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002230
has_obo_namespace: uberon
id: ends_with
in_subset: eco subset
shorthand: ends_with

has developmental contribution from
type: ObjectProperty
sub property of: has material contribution from
type: TransitiveProperty
property chain axiom: has part
property chain axiom: develops_from
imported from: uberon.owl
database_cross_reference: RO:0002254
has_obo_namespace: uberon
id: has_developmental_contribution_from
shorthand: has_developmental_contribution_from

developmentally_induced_by
type: ObjectProperty
definition: t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.
imported from: uberon.owl
database_cross_reference: RO:0002256
has_obo_namespace: uberon
id: developmentally_induced_by
shorthand: developmentally_induced_by
comment: sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)

developmentally preceded by
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0002258
has_obo_namespace: uberon
id: developmentally_preceded_by
shorthand: developmentally_preceded_by

developmentally_replaces
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0002285
has_obo_namespace: uberon
id: developmentally_replaces
shorthand: developmentally_replaces

results in formation of
type: ObjectProperty
example of usage: example of usage: every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062); an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists.
definition editor: Chris Mungall

mereotopologically related to
type: ObjectProperty
definition: A mereological relationship or a topological relationship
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
imported from: ro.owl
temporal interpretation: RO_0001901

has member
type: ObjectProperty
sub property of: has part
imported from: uberon.owl
database_cross_reference: RO:0002351
has_obo_namespace: uberon
id: has_member
shorthand: has_member

attaches_to
type: ObjectProperty
sub property of: connects
sub property of: attaches_to_part_of
imported from: uberon.owl
has_alternative_id: FMA:85990
database_cross_reference: RO:0002371
has_obo_namespace: uberon
id: attaches_to
shorthand: attaches_to

branching_part_of
type: ObjectProperty
sub property of: part of
inverse of: has_branching_part
editor note: we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve
imported from: uberon.owl
has_alternative_id: FMA:85994
database_cross_reference: RO:0002380
has_obo_namespace: uberon
id: branching_part_of
shorthand: branching_part_of

has potential to developmentally contribute to
type: ObjectProperty
definition: x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
imported from: uberon.owl
database_cross_reference: RO:0002385
has_obo_namespace: uberon
id: has_potential_to_developmentally_contribute_to
shorthand: has_potential_to_developmentally_contribute_to

has potential to develop into
type: ObjectProperty
definition: x has the potential to develop into y iff x develops into y or if x is capable of developing into y
imported from: uberon.owl
database_cross_reference: RO:0002387
has_obo_namespace: uberon
id: has_potential_to_develop_into
shorthand: has_potential_to_develop_into

contributes to morphology of
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0002433
has_obo_namespace: uberon
id: contributes_to_morphology_of
shorthand: contributes_to_morphology_of

composed primarily of
type: ObjectProperty
sub property of: has part
definition: x composed_primarily_of y iff: more than half of the mass of x is made from parts of y
imported from: uberon.owl
has_alternative_id: UBREL:0000002
database_cross_reference: RO:0002473
has_obo_namespace: uberon
id: composed_primarily_of
shorthand: composed_primarily_of

existence starts during
type: ObjectProperty
sub property of: existence starts during or after
property chain axiom: part of
definition: Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.
imported from: uberon.owl
has_alternative_id: BFO:0000068
database_cross_reference: RO:0002488
has_exact_synonym: begins_to_exist_during
has_obo_namespace: uberon
id: existence_starts_during
shorthand: existence_starts_during

existence starts with
type: ObjectProperty
sub property of: existence starts during
definition: Relation between continuant and occurrent, such that c comes into existence at the start of p.
imported from: uberon.owl
database_cross_reference: RO:0002489
has_obo_namespace: uberon
id: existence_starts_with
shorthand: existence_starts_with

existence ends during
type: ObjectProperty
sub property of: existence ends during or before
property chain axiom: part of
definition: Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.
imported from: uberon.owl
has_alternative_id: BFO:0000069
database_cross_reference: RO:0002492
has_exact_synonym: ceases_to_exist_during
has_obo_namespace: uberon
id: existence_ends_during
shorthand: existence_ends_during

existence ends with
type: ObjectProperty
sub property of: existence ends during
definition: Relation between continuant and occurrent, such that c ceases to exist at the end of p.
imported from: uberon.owl
database_cross_reference: RO:0002493
has_obo_namespace: uberon
id: existence_ends_with
shorthand: existence_ends_with

transformation of
type: ObjectProperty
sub property of: develops_from
type: TransitiveProperty
imported from: uberon.owl
database_cross_reference: RO:0002494
has_exact_synonym: transforms from
has_obo_namespace: uberon
id: transformation_of
shorthand: transformation_of

immediate transformation of
type: ObjectProperty
sub property of: transformation of
imported from: uberon.owl
database_cross_reference: RO:0002495
has_exact_synonym: direct_transformation_of
has_exact_synonym: immediately transforms from
has_obo_namespace: uberon
id: immediate_transformation_of
shorthand: immediate_transformation_of

existence starts during or after
type: ObjectProperty
property chain axiom: part of
property chain axiom: developmentally preceded by
property chain axiom: preceded_by
property chain axiom: simultaneous_with
imported from: uberon.owl
database_cross_reference: RO:0002496
has_obo_namespace: uberon
id: existence_starts_during_or_after
shorthand: existence_starts_during_or_after

existence ends during or before
type: ObjectProperty
property chain axiom: part of
property chain axiom: precedes
property chain axiom: simultaneous_with
imported from: uberon.owl
database_cross_reference: RO:0002497
has_obo_namespace: uberon
id: existence_ends_during_or_before
shorthand: existence_ends_during_or_before

has material contribution from
type: ObjectProperty
type: TransitiveProperty
property chain axiom: has part
property chain axiom: develops_from
imported from: uberon.owl
database_cross_reference: RO:0002507
has_obo_namespace: uberon
id: has_material_contribution_from
shorthand: has_material_contribution_from

has skeleton
type: ObjectProperty
sub property of: has part
inverse of: skeleton of
definition: A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision.
imported from: uberon.owl
database_cross_reference: RO:0002551
has_obo_namespace: uberon
has_related_synonym: has sekeletal support
has_related_synonym: has supporting framework
id: has_skeleton
shorthand: has_skeleton

has_branching_part
type: ObjectProperty
type: TransitiveProperty
imported from: uberon.owl
database_cross_reference: RO:0002569
has_obo_namespace: uberon
id: has_branching_part
shorthand: has_branching_part

luminal space of
type: ObjectProperty
sub property of: part of
imported from: uberon.owl
database_cross_reference: RO:0002572
has_obo_namespace: uberon
id: luminal_space_of
shorthand: luminal_space_of

skeleton of
type: ObjectProperty
sub property of: part of
imported from: uberon.owl
database_cross_reference: RO:0002576
has_obo_namespace: uberon
id: skeleton_of
shorthand: skeleton_of

produces
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0003000
has_obo_namespace: uberon
id: produces
shorthand: produces

produced_by
type: ObjectProperty
imported from: uberon.owl
database_cross_reference: RO:0003001
has_obo_namespace: uberon
id: produced_by
shorthand: produced_by

anteriorly connected to
type: ObjectProperty
sub property of: posterior_to
sub property of: connected to
sub property of: transitively anteriorly connected to
definition: x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.
imported from: uberon.owl
has_obo_namespace: uberon
id: anteriorly_connected_to

channel for
type: ObjectProperty
imported from: uberon.owl
has_broad_synonym: carries
has_obo_namespace: uberon
id: channel_for

channels_from
type: ObjectProperty
type: TransitiveProperty
imported from: uberon.owl
has_obo_namespace: uberon
id: channels_from

channels_into
type: ObjectProperty
type: TransitiveProperty
imported from: uberon.owl
has_obo_namespace: uberon
id: channels_into

conduit for
type: ObjectProperty
definition: x is a conduit for y iff y passes through the lumen of x.
imported from: uberon.owl
has_obo_namespace: uberon
id: conduit_for

distally connected to
type: ObjectProperty
sub property of: proximal_to
sub property of: connected to
sub property of: transitively distally connected to
inverse of: proximally connected to
definition: x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.
imported from: uberon.owl
has_obo_namespace: uberon
id: distally_connected_to

evolved_from
type: ObjectProperty
sub property of: homologous_to
imported from: uberon.owl
has_obo_namespace: uberon
id: evolved_from
comment: Status: experimental

existence starts and ends during
type: ObjectProperty
sub property of: existence starts during
sub property of: existence ends during
imported from: uberon.owl
has_obo_namespace: uberon
id: existence_starts_and_ends_during

extends_fibers_into
type: ObjectProperty
sub property of: connected to
type: SymmetricProperty
imported from: uberon.owl
has_obo_namespace: uberon
id: extends_fibers_into

in_central_side_of
type: ObjectProperty
sub property of: part of
definition: X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides.
imported from: uberon.owl
has_obo_namespace: uberon
id: in_central_side_of

posteriorly connected to
type: ObjectProperty
sub property of: anterior_to
sub property of: connected to
definition: x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.
imported from: uberon.owl
has_obo_namespace: uberon
id: posteriorly_connected_to

protects
type: ObjectProperty
imported from: uberon.owl
has_obo_namespace: uberon
id: protects

proximally connected to
type: ObjectProperty
sub property of: distal_to
sub property of: connected to
sub property of: transitively proximally connected to
definition: x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.
imported from: uberon.owl
has_obo_namespace: uberon
id: proximally_connected_to

subdivision of
type: ObjectProperty
imported from: uberon.owl
has_obo_namespace: uberon
id: subdivision_of
comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B

transitively anteriorly connected to
type: ObjectProperty
type: TransitiveProperty
definition: .
imported from: uberon.owl
has_obo_namespace: uberon
id: transitively_anteriorly_connected_to

transitively_connected to
type: ObjectProperty
type: TransitiveProperty
imported from: uberon.owl
has_obo_namespace: uberon
id: transitively_connected_to

transitively distally connected to
type: ObjectProperty
type: TransitiveProperty
definition: .
imported from: uberon.owl
has_obo_namespace: uberon
id: transitively_distally_connected_to

transitively proximally connected to
type: ObjectProperty
type: TransitiveProperty
definition: .
imported from: uberon.owl
has_obo_namespace: uberon
id: transitively_proximally_connected_to

has size
type: DatatypeProperty
definition editor: A data property that indicates that a material entity has a particular size.
definition editor: Yongqun He

has diameter in cm
type: DatatypeProperty
sub property of: has size
example of usage: A ulcer has a diameter in cm some specific decimal length
definition: A 'has size' object property that indicates a material entity of round shape has a diameter of a particular length with the cm (centimeter) unit.
definition editor: Yongqun He

entity
type: Class
BFO OWL specification label: entity
BFO CLIF specification label: Entity
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
imported from: bfo.owl
imported from: obi.owl
imported from: ogms.owl
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])

continuant
type: Class
subclass of: entity
BFO OWL specification label: continuant
BFO CLIF specification label: Continuant
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
imported from: bfo.owl
imported from: obi.owl
imported from: ro.owl
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]

occurrent
type: Class
subclass of: entity
BFO OWL specification label: occurrent
BFO CLIF specification label: Occurrent
definition: An entity that has temporal parts and that happens, unfolds or develops through time.
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
imported from: bfo.owl
imported from: obi.owl
imported from: ro.owl
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]

independent continuant
type: Class
subclass of: continuant
BFO OWL specification label: ic
BFO CLIF specification label: IndependentContinuant
example of usage: a chair
example of usage: a heart
example of usage: a leg
example of usage: a molecule
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
definition: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
imported from: bfo.owl
imported from: obi.owl
imported from: ro.owl
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]

temporal region
type: Class
subclass of: occurrent
BFO OWL specification label: t-region
BFO CLIF specification label: TemporalRegion
editor note: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
imported from: bfo.owl
imported from: obi.owl
elucidation: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has associated axiom(nl): All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has associated axiom(nl): Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has associated axiom(fol): (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has associated axiom(fol): (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has associated axiom(fol): (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]

process
type: Class
subclass of: occurrent
BFO OWL specification label: process
BFO CLIF specification label: Process
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
example of usage: the course of a disease
example of usage: the flight of a bird
example of usage: the life of an organism
example of usage: your process of aging.
definition: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
imported from: bfo.owl
imported from: obi.owl
imported from: ro.owl
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]

disposition
type: Class
subclass of: realizable entity
BFO OWL specification label: disposition
BFO CLIF specification label: Disposition
example of usage: an atom of element X has the disposition to decay to an atom of element Y
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
imported from: bfo.owl
imported from: obi.owl
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]

realizable entity
type: Class
subclass of: specifically dependent continuant
BFO OWL specification label: realizable
BFO CLIF specification label: RealizableEntity
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
imported from: bfo.owl
imported from: obi.owl
imported from: ro.owl
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]

quality
type: Class
subclass of: specifically dependent continuant
BFO OWL specification label: quality
BFO CLIF specification label: Quality
example of usage: the ambient temperature of this portion of air
example of usage: the color of a tomato
example of usage: the length of the circumference of your waist
example of usage: the mass of this piece of gold.
example of usage: the shape of your nose
example of usage: the shape of your nostril
imported from: bfo.owl
imported from: ro.owl
elucidation: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
has associated axiom(nl): If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
has associated axiom(fol): (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
has associated axiom(fol): (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]

specifically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: sdc
BFO CLIF specification label: SpecificallyDependentContinuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
definition: b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
imported from: bfo.owl
imported from: obi.owl
imported from: ro.owl
has associated axiom(fol): (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]

role
type: Class
subclass of: realizable entity
BFO OWL specification label: role
BFO CLIF specification label: Role
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
definition: A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
imported from: bfo.owl
imported from: obi.owl
imported from: ro.owl
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]

object aggregate
type: Class
subclass of: material entity
BFO OWL specification label: object-aggregate
BFO CLIF specification label: ObjectAggregate
example of usage: a collection of cells in a blood biobank.
example of usage: a swarm of bees is an aggregate of members who are linked together through natural bonds
example of usage: a symphony orchestra
example of usage: an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)
example of usage: defined by fiat: the aggregate of members of an organization
example of usage: defined through physical attachment: the aggregate of atoms in a lump of granite
example of usage: defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container
example of usage: defined via attributive delimitations such as: the patients in this hospital
example of usage: the aggregate of bearings in a constant velocity axle joint
example of usage: the aggregate of blood cells in your body
example of usage: the nitrogen atoms in the atmosphere
example of usage: the restaurants in Palo Alto
example of usage: your collection of Meissen ceramic plates.
editor note: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
editor note: BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee).
definition source: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
imported from: bfo.owl
elucidation: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
has associated axiom(fol): (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]

site
type: Class
subclass of: immaterial entity
BFO OWL specification label: site
BFO CLIF specification label: Site
example of usage: Manhattan Canyon)
example of usage: a hole in the interior of a portion of cheese
example of usage: a rabbit hole
example of usage: an air traffic control region defined in the airspace above an airport
example of usage: the Grand Canyon
example of usage: the Piazza San Marco
example of usage: the cockpit of an aircraft
example of usage: the hold of a ship
example of usage: the interior of a kangaroo pouch
example of usage: the interior of the trunk of your car
example of usage: the interior of your bedroom
example of usage: the interior of your office
example of usage: the interior of your refrigerator
example of usage: the lumen of your gut
example of usage: your left nostril (a fiat part – the opening – of your left nasal cavity)
imported from: bfo.owl
imported from: obi.owl
elucidation: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has associated axiom(fol): (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]

object
type: Class
subclass of: material entity
BFO OWL specification label: object
BFO CLIF specification label: Object
example of usage: atom
example of usage: cell
example of usage: cells and organisms
example of usage: engineered artifacts
example of usage: grain of sand
example of usage: molecule
example of usage: organelle
example of usage: organism
example of usage: planet
example of usage: solid portions of matter
example of usage: star
editor note: BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
editor note: BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
editor note: BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
editor note: BFO 2 Reference: an object is a maximal causally unified material entity
editor note: BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
imported from: bfo.owl
elucidation: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])

generically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: gdc
BFO CLIF specification label: GenericallyDependentContinuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
definition: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
imported from: bfo.owl
imported from: obi.owl
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]

function
type: Class
subclass of: disposition
BFO OWL specification label: function
BFO CLIF specification label: Function
example of usage: the function of a hammer to drive in nails
example of usage: the function of a heart pacemaker to regulate the beating of a heart through electricity
example of usage: the function of amylase in saliva to break down starch into sugar
editor note: BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
imported from: bfo.owl
elucidation: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
has associated axiom(fol): (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]

one-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 1d-t-region
BFO CLIF specification label: OneDimensionalTemporalRegion
example of usage: the temporal region during which a process occurs.
editor note: BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
imported from: bfo.owl
imported from: obi.owl
elucidation: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]

material entity
type: Class
subclass of: independent continuant
BFO OWL specification label: material
BFO CLIF specification label: MaterialEntity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
example of usage: the undetached arm of a human being
definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
imported from: bfo.owl
imported from: obi.owl
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]

immaterial entity
type: Class
subclass of: independent continuant
BFO OWL specification label: immaterial
BFO CLIF specification label: ImmaterialEntity
editor note: BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10
imported from: bfo.owl
imported from: obi.owl

relational quality
type: Class
subclass of: quality
BFO OWL specification label: r-quality
BFO CLIF specification label: RelationalQuality
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: a marriage bond, an instance of love, an obligation between one person and another.
definition: b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
imported from: bfo.owl
has associated axiom(fol): (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]

zero-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 0d-t-region
BFO CLIF specification label: ZeroDimensionalTemporalRegion
example of usage: a temporal region that is occupied by a process boundary
example of usage: right now
example of usage: the moment at which a child is born
example of usage: the moment at which a finger is detached in an industrial accident
example of usage: the moment of death.
alternative term: temporal instant.
imported from: bfo.owl
imported from: obi.owl
elucidation: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]

neuropathy
type: Class
subclass of: OGMS_0000031
definition: A nervous system disease that is located_in nerves or nerve cells.
imported from: doid.owl
database_cross_reference: ICD10CM:G62.9
database_cross_reference: NCI:C4731
database_cross_reference: SNOMEDCT_US_2018_03_01:193167000
database_cross_reference: SNOMEDCT_US_2018_03_01:264554005
database_cross_reference: SNOMEDCT_US_2018_03_01:277317008
database_cross_reference: SNOMEDCT_US_2018_03_01:277878001
database_cross_reference: SNOMEDCT_US_2018_03_01:386033004
database_cross_reference: SNOMEDCT_US_2018_03_01:42658009
database_cross_reference: UMLS_CUI:C0442874
has_exact_synonym: peripheral neuropathy
has_obo_namespace: disease_ontology
id: DOID:870

biological_process
type: Class
subclass of: process
definition: Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
imported from: go.owl
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_exact_synonym: physiological process
has_obo_namespace: biological_process
id: GO:0008150
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.

cell death
type: Class
subclass of: death
subclass of: single-organism cellular process
definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
imported from: go.owl
has_obo_namespace: biological_process
has_related_synonym: accidental cell death
has_related_synonym: necrosis
id: GO:0008219
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.

cellular process
type: Class
subclass of: biological_process
definition: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
imported from: go.owl
has_alternative_id: GO:0008151
has_alternative_id: GO:0050875
has_exact_synonym: cell physiology
has_exact_synonym: cellular physiological process
has_narrow_synonym: cell growth and/or maintenance
has_obo_namespace: biological_process
id: GO:0009987
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

death
type: Class
subclass of: single-organism process
definition: A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
imported from: go.owl
database_cross_reference: Wikipedia:Death
has_obo_namespace: biological_process
id: GO:0016265
in_subset: goslim plant
in_subset: gosubset prok
comment: See also the biological process term 'apoptosis ; GO:0006915'.

single-organism process
type: Class
subclass of: biological_process
definition: A biological process that involves only one organism.
imported from: go.owl
created by: janelomax
creation date: 2012-09-19T15:05:24Z
has_exact_synonym: single organism process
has_obo_namespace: biological_process
id: GO:0044699

single-organism cellular process
type: Class
subclass of: cellular process
subclass of: single-organism process
definition: Any process that is carried out at the cellular level, occurring within a single organism.
imported from: go.owl
created by: janelomax
creation date: 2012-12-11T16:56:55Z
has_obo_namespace: biological_process
id: GO:0044763

necrotic cell death
type: Class
subclass of: cell death
definition: A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
imported from: go.owl
has_broad_synonym: necrosis
has_exact_synonym: cellular necrosis
has_obo_namespace: biological_process
id: GO:0070265
comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.

data item
type: Class
subclass of: information content entity
editor preferred label: data item
example of usage: Data items include counts of things, analyte concentrations, and statistical summaries.
has curation status: IAO_0000125
definition: a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.
editor note: 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers.
editor note: 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum.
editor note: 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym.
editor note: 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/
editor note: JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Chris Stoeckert
definition editor: PERSON: Jonathan Rees
alternative term: data
imported from: iao.owl
imported from: obi.owl

information content entity
type: Class
subclass of: generically dependent continuant
editor preferred label: information content entity
example of usage: Examples of information content entites include journal articles, data, graphical layouts, and graphs.
has curation status: IAO_0000122
definition: A generically dependent continuant that is about some thing.
editor note: 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ).
editor note: information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity.
definition editor: PERSON: Chris Stoeckert
definition source: OBI_0000142
imported from: iao.owl
imported from: obi.owl

textual entity
type: Class
subclass of: information content entity
editor preferred label: textual entity
example of usage: Words, sentences, paragraphs, and the written (non-figure) parts of publications are all textual entities
has curation status: IAO_0000123
definition: A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc.
editor note: AR, (IAO call 2009-09-01): a document as a whole is not typically a textual entity, because it has pictures in it - rather there are parts of it that are textual entities. Examples: The title, paragraph 2 sentence 7, etc.
editor note: MC, 2009-09-14 (following IAO call 2009-09-01): textual entities live at the FRBR (http://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records) manifestation level. Everything is significant: line break, pdf and html versions of same document are different textual entities.
definition editor: PERSON: Lawrence Hunter
alternative term: text
imported from: iao.owl
imported from: obi.owl

hypothesis textual entity
type: Class
subclass of: textual entity
editor preferred label: hypothesis textual entity
example of usage: that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper 'Pilot clinical study to evaluate the anticoagulant activity of fucoidan', by Lowenthal et. al.PMID:19696660
has curation status: IAO_0000120
definition: A textual entity that expresses an assertion that is intended to be tested.
editor note: 2009/09/28 Alan Ruttenberg. Fucoidan-use-case
definition editor: Person:Alan Ruttenberg
imported from: iao.owl
imported from: obi.owl

adverse event
type: Class
subclass of: OGMS_0000061
subclass of: Restriction
  on property: preceded_by
  some values from: medical intervention
definition: a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.
editor note: Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.
editor note: YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.
editor note: YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.
editor note: YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623.
editor note: YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740.
editor note: YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.
editor note: YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'.
definition editor: Yongqun He
alternative term: AE
alternative term: adverse reaction
definition source: WEB: http://en.wikipedia.org/wiki/Adverse_event
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068
comment: The OAE official website is: http://www.oae-ontology.org/.

medical intervention
type: Class
subclass of: OBI_0000011
definition: medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury.
editor note: The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States," Reference: http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis.
definition editor: YH
definition source: WEB: http://wiki.answers.com/Q/What_is_medical_intervention

causal adverse event
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: induced_by
    some values from: medical intervention
subclass of: adverse event
definition: an adverse event which is a causal adverse event, a pathological bodily process that is induced by a medical intervention.
editor note: YH: The term 'causal adverse event' has the same meaning as we previously defined as 'adverse event'. Reference: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing as a way to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention.
definition editor: YH
alternative term: adverse effect
definition source: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper.
comment: YH: the term "adverse effect" has the same meaning of "causal adverse event".

vaccine adverse event
type: Class
subclass of: adverse event
subclass of: Restriction
  on property: preceded_by
  some values from: VO_0000002
definition: an adverse event that occurs after a vaccination.
definition editor: YH

adverse drug event
type: Class
subclass of: adverse event
subclass of: Restriction
  on property: preceded_by
  some values from: drug administration
definition: an adverse event that occurs after a drug administration
definition editor: YH, JX
alternative term: ADE
alternative term: ADR
alternative term: adverse drug reaction
alternative term: drug adverse event

obsolete: medical device adverse event
type: Class
subclass of: ObsoleteClass
definition: an adverse event that is associated with the usage of a medical device.
definition editor: YH
comment: This term is obsolete due to another term that has the same meaning.

medical food adverse event
type: Class
subclass of: nutritional product adverse event
subclass of: Restriction
  on property: induced_by
  some values from: consumption of medical food
definition: an adverse event that is associated with eating a medical food.
definition editor: YH

nutritional product adverse event
type: Class
subclass of: adverse event
definition: an adverse event that is induced by consuming a nutritional product.
definition editor: YH

dietary supplement adverse event
type: Class
subclass of: nutritional product adverse event
subclass of: Restriction
  on property: induced_by
  some values from: dietary supplement consumption
definition: an adverse event that is associated with consuming a dietary supplement.
definition editor: YH

infant formula adverse event
type: Class
subclass of: nutritional product adverse event
subclass of: Restriction
  on property: induced_by
  some values from: consumption of infant formula
definition: an adverse event that is associated with consuming an infant formula.
definition editor: YH

drug administration
type: Class
subclass of: medical intervention
definition: a medical intervention where a patient is administered with a drug
definition editor: YH

medical device usage for medical intervention
type: Class
subclass of: medical intervention
definition: a medical intervention that uses a medical device
definition editor: YH

nutritional product usage
type: Class
subclass of: medical intervention
definition: a medical intervention that uses a nutritional product
definition editor: YH
alternative term: consumption of nutritional product

dietary supplement consumption
type: Class
subclass of: nutritional product usage
definition: a nutritional product usage that consumes a dietary supplement
definition editor: YH

consumption of infant formula
type: Class
subclass of: nutritional product usage
definition: a nutritional product usage that consumes infant formula
definition editor: YH

consumption of medical food
type: Class
subclass of: nutritional product usage
definition: a nutritional product usage that consumes medial food
definition editor: YH

X-ray result abnormal AE
type: Class
subclass of: imaging investigation result abnormal AE
definition: an imaging investigation result abnormal AE that is characterized by an abnormal X-ray
definition editor: SS, YH, EB
has_MedDRA_id: 10048065

chest X-ray abnormal AE
type: Class
subclass of: X-ray result abnormal AE
definition: an X-ray result abnormal AE that has an outcome of an abnormality in chest X-ray test
definition editor: SS, YH
has_MedDRA_id: 10008499

contusion AE
type: Class
subclass of: hematoma AE
definition: a haematoma AE that has an outcome of contusion.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Bruise
has_MedDRA_id: 10050584
comment: Contusion is a type of relatively minor hematoma of tissue in which capillaries and sometimes venules are damaged by trauma, allowing blood to seep into the surrounding interstitial tissues.

dry throat AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000341
definition: a digestive system AE which has an outcome of dry throat, which is a sensation of dryness in the throat.
definition editor: SS, YH
has_MedDRA_id: 10013789

flushing AE
type: Class
subclass of: skin discoloration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin discoloration AE which has an outcome of flushing, a sudden reddening of the face, neck, or upper chest
definition editor: SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003241.htm
Chinese translation: 脸红
has_MedDRA_id: 10016825
see also: HPO: HP_0001033
see also: SIDER: C0016382

pain in extremity AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE where the pain reachs an extreme level.
definition editor: SS, YH, MW
has_MedDRA_id: 10033425
see also: CTCAE: E12512
see also: HPO: HP_0009763
see also: NCIt: C78515
see also: SIDER: C0030196

postnasal drip AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a respiratory system AE which has an outcome of postnasal drip, which occurs when excessive mucus is produced by the nasal Mucosa. The excess mucus accumulates in the throat or back of the nose.
definition editor: SS, YH
alternative term: PDN
alternative term: UACS
alternative term: Upper Airway Cough Syndrome
definition source: WEB: http://en.wikipedia.org/wiki/Post-nasal_drip
has_MedDRA_id: 10036402
see also: CTCAE: E13514
see also: NCIt: C78566

cardiorenal syndrome AE
type: Class
subclass of: syndrome AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac failure AE
definition: a syndrome AE that is subclassified as five defined entities which represent clinical circumstances in which both the heart and the kidney are involved in a bidirectional injury and dysfunction via a final common pathway of cell-to-cell death and accelerated apoptosis mediated by oxidative stress. Types 1 and 2 involve acute and chronic cardiovascular disease (CVD) scenarios leading to acute kidney injury or accelerated chronic kidney disease. Types 2 and 3 describe acute and chronic kidney disease leading primarily to heart failure, although it is possible that acute coronary syndromes, stroke, and arrhythmias could be CVD outcomes in these forms of CRS. Finally, CRS type 5 describes a simultaneous insult to both heart and kidneys, such as sepsis, where both organs are injured simultaneously.
definition editor: SS, YH
alternative term: CRS
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030731/
has_MedDRA_id: 10068230

bursitis AE
type: Class
subclass of: bursal disorder AE
definition: A bursal disorder AE that has an outcome of the symptom of bursitis.
definition editor: SS, YH
alternative term: bursa inflammation
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001456/

musculoskeletal or connective tissue AE
type: Class
subclass of: adverse event
definition: an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue.
definition editor: YH, RR, JX
alternative term: musculoskeletal and connective tissue disorder AE
definition source: WEB: http://www.cdc.gov/niosh/programs/msd/
has_MedDRA_id: 10028395
comment: A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture
see also: CTCAE: E13872

causal adverse event hypothesis
type: Class
subclass of: hypothesis textual entity
editor note: A statistical test can be used to accept or reject the hypothesis.
definition editor: YH
definition editor: a hypothesis about the causal relation between an adverse event and a medical intervention. This term can be used to hypothesize and evaluate the relation between a medical intervention (e.g., drug, vaccination) and case reports from an adverse event reporting system (e.g., VAERS).
alternative term: CAE hypothesis

bursal disorder AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal system AE which has an outcome of bursal disorder
definition editor: YH

influenza vaccine-induced adverse event
type: Class
subclass of: vaccine-induced adverse event
definition: a vaccine adverse event that is induced by an influenza vaccine.
editor note: YH: This term is just used as an example of vaccine induced adverse events. Specific vaccine-associated and vaccine-induced adverse events are now represented with the Ontology of Vaccine Adverse Events (OVAE).: http://www.violinet.org/ovae/.
definition editor: YH

KIV-induced adverse event
type: Class
subclass of: influenza vaccine-induced adverse event
definition: an influenza vaccine adverse event that is induced by a killed influenza vaccine (KIV).
definition editor: YH

KIV-induced GBS averse event in 1976-1977
type: Class
subclass of: KIV-induced adverse event
definition: A KIV-induced AE that results in a GBS.
definition editor: YH
definition source: VAERS statistical data analysis
comment: There is little evidence to support a causal association between GBS and most vaccines. The evidence for a causal association is strongest for the swine influenza vaccine that was used in 1976-77. Studies of influenza vaccines used in subsequent years, however, have found small or no increased risk of GBS. Reference: http://www.ncbi.nlm.nih.gov/pubmed?term=19388722.

Afluria-induced muscle ache AE
type: Class
equivalent class: Class
  intersection of: muscle ache AE
  intersection of: Restriction
    on property: induced_by
    some values from: Afluria administration
subclass of: Afluria-induced adverse event
definition: a muscle pain AE that is induced by Afluria influenza vaccine administration
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf

fatigue AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities.
editor note: lethargy is sometimes reported as an extreme fatigue: http://the-difference-between.com/lethargy/fatigue they are sometimes regarded as synonyms: https://www.nlm.nih.gov/medlineplus/ency/article/003088.htm
definition editor: SS, YH, MW
alternative term: lethargy AE
definition source: WEB: http://en.wikipedia.org/wiki/Fatigue_%28medical%29
has_MedDRA_id: 10016256
has_MedDRA_id: 10024264
see also: CTCAE: E11098 (fatigue); CTCAE: E12709 (lethargy)
see also: HPO: HP_0003388
see also: NCIt: C3036; NCIt: C78416
see also: SIDER: C0015672

CSF culture negative AE
type: Class
subclass of: microbiology and serology investigation result abnormal AE
definition: a microbiology and serology investigation result abnormal AE that has an outcome of CSF culture negative. The negative result means no bacteria, viruses, or fungi grew in the laboratory dish.
editor note: YH: The negative result is normal. It is not an AE.
definition editor: SS, YH, EB

blood cell lab test abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a lab test abnormal AE that has an outcome of an abnormal result in a blood cell lab test
definition editor: SS, YH

eosinophil percentage increased AE
type: Class
subclass of: eosinophil percentage abnormal AE
definition: an eosinophil percentage abnormal AE that has an outcome of increased eosinophil percentage
definition editor: YH, EB
has_MedDRA_id: 10052222

myocardial infarction AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: arteriosclerosis coronary artery AE
subclass of: Restriction
  on property: is evidence of
  some values from: toxin-induced cardiomyopathy AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac embolism AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by an obstruction of the blood supply to the heart
definition editor: SS
definition source: WEB: http://www.ncbi.nlm.nih.gov/mesh/68009203
Chinese translation: 心肌梗塞
has_MedDRA_id: 10028596
see also: CTCAE: E10152
see also: HPO: HP_0001658
see also: NCIt: C27996
see also: SIDER: C0027051

neutrophil count increased AE
type: Class
subclass of: neutrophil count abnormal AE
definition: a neutrophil count abnormal AE that has an outcome of increased neutrophil count
definition editor: YH
has_MedDRA_id: 10029368
see also: HPO: HP_0011991
see also: SIDER: NA

procedural complication AE
type: Class
subclass of: adverse event
definition: an adverse event that shows a complication that occurs after a medical procedure such as a surgery.
definition editor: SS, YH
alternative term: post-procedural AE
alternative term: procedural disorder AE
alternative term: procedure AE

injury AE
type: Class
subclass of: adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an adverse event that has an outcome of injury after a medical intervention.
definition editor: SS, YH
has_MedDRA_id: 10022116

head injury AE
type: Class
subclass of: injury AE
definition: an injury AE which has an outcome of head injury
definition editor: SS, YH
has_MedDRA_id: 10019196

social behavior AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an abnormal outcome in social behavior
definition editor: SS, YH

impaired work ability AE
type: Class
subclass of: social behavior AE
definition: a social behavior AE that has an outcome of impaired work ability
definition editor: SS, YH

injection-site allergic reaction AE
type: Class
subclass of: injection-site AE
subclass of: allergy AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: an allergy AE which has an outcome of injection-site allergic reaction
has_MedDRA_id: 10022095

myelitis transverse AE
type: Class
subclass of: myelitis AE
definition: a myelitis AE which has an outcome of myelitis transverse. Transverse myelitis (in Latin nomenclature: myelitis transversa) is a neurological disorder caused by an inflammatory process of the spinal cord, and can cause axonal demyelination.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Transverse_myelitis
has_MedDRA_id: 10028527

skin warm AE
type: Class
subclass of: skin AE
definition: a skin adverse even that has an outcome of warm skin
definition editor: SS, YH

nystagmus AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
definition: Nystagmus AE is an eye AE that is a condition of involuntary eye movement, acquired in infancy or later in life, that may result in reduced or limited vision. Due to the involuntary movement of the eye, it is often called "dancing eyes".
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Nystagmus
has_MedDRA_id: 10029864

dermatitis bullous AE
type: Class
subclass of: dermatitis AE
definition: a dermatitis AE that has an outcome of dermatitis bullous
definition editor: SS, YH
alternative term: bullous pemphigoid AE
has_MedDRA_id: 10012441
comment: Bullous pemphigoid is a skin disorder characterized by large blisters.
see also: HPO: HP_0011123
see also: SIDER: C0085932

hot flushes AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin adverse event that is characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling.
definition editor: SS, YH, MW
alternative term: hot flash AE
alternative term: hot flashes AE
alternative term: hot flush AE
has_MedDRA_id: 10020407
see also: CTCAE: E13781
see also: HPO: HP_0008209
see also: NCIt: C3109
see also: SIDER: C0600142

Afluria-induced adverse event
type: Class
subclass of: KIV-induced adverse event
definition: a KIV-induced adverse event that has an outcome of Afluria-induced adverse event
definition editor: YH

tumor AE
type: Class
subclass of: adverse event
definition: an adverse event that results in the outcome of a tumor.
alternative term: mass AE
alternative term: nodule AE
alternative term: tumour AE
has_MedDRA_id: 10026865
creator: YH, RR

wheezing AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE which has an outcome of wheezing, a high-pitched whistling sound made while breathing.
definition editor: SS, YH, MW
definition source: WEB: http://www.mayoclinic.org/symptoms/wheezing/basics/definition/sym-20050764
has_MedDRA_id: 10047924

weight bearing difficulty AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of weight bearing difficulty
definition: weight bearing difficulty is a behavior AE that results in difficulty in managing the amount of weight a patient puts on the leg on which surgery has been performed. In general, it is described as a percentage of the body weight, because each leg of a healthy person carries the full body weight when walking, in an alternating fashion.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Weight-bearing

contraindication
type: Class
subclass of: disposition
definition: A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment.
definition editor: Yongqun He, Sirarat Sarntivijai, Mathias Brochhausen, William Hogan, ‎Philip E. Empey
definition source: http://en.wikipedia.org/wiki/Contraindication

incorrect drug dose administration
type: Class
subclass of: errored drug administration
definition: a drug administration that uses incorrect drug dose
definition editor: YH

Afluria-induced fever AE in child
type: Class
subclass of: Afluria-induced adverse event
definition: an Afluria-induced adverse event that has an outcome of Afluria-induced fever in child
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf

Afluria-induced cough AE in child
type: Class
subclass of: Afluria-induced adverse event
definition: an Afluria-induced adverse event that has an outcome of Afluria-induced cough in child
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf

Afluria-induced injection site pain AE
type: Class
subclass of: Afluria-induced adverse event
definition: an Afluria-induced adverse event which has an outcome of Afluria-induced injection site pain
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf

Afluria-induced injection site redness AE
type: Class
subclass of: Afluria-induced adverse event
definition: an Afluria-induced adverse event that has an outcome of Afluria-induced injection site redness
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf

Afluria-induced inject site swelling AE
type: Class
subclass of: Afluria-induced adverse event
definition: an Afluria-induced AE that has an outcome of Afluria-induced inject site swelling
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf

Afluria-induced headache AE
type: Class
subclass of: Afluria-induced adverse event
definition: an Afluria-induced adverse event that has an outcome of Afluria-induced headache
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf

systematic AE
type: Class
subclass of: adverse event
definition: an adverse event that occurs systematically throughout the systemic circulation. This is different from local adverse event that is limited or a certain location.
definition editor: YH, JX
alternative term: systematic adverse event
definition source: URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction

pregnancy AE
type: Class
subclass of: prenatal, perinatal or neonatal disorder AE
definition: A pregnancy, neonatal and perinatal AE that displays a disorder associated with pregnancy.
alternative term: prenatal AE
definition source: WEB: https://en.wikipedia.org/wiki/Complications_of_pregnancy
definition source: WEB: https://en.wikipedia.org/wiki/Prenatal_diagnosis
creator: YH, JX

adverse event incubation time
type: Class
subclass of: one-dimensional temporal region
definition: a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event outcome appears. This is the time = 'time instant of an adverse event outcome observed' - 'time instant of medical intervention'.
definition editor: YH, XZ

surgery adverse event
type: Class
equivalent class: Restriction
  on property: adverse event preceded by
  some values from: surgery
subclass of: procedural complication AE
subclass of: Restriction
  on property: preceded by
  some values from: surgery
definition: a procedure complication AE that occurs after a surgery.
definition editor: YH
alternative term: surgery AE
alternative term: surgery adverse event
alternative term: surgical procedure AE
comment: The key difference between a surgery and a procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. Technically speaking, a surgery is a specific type of procedure. A procedure is a broad general term that refers to any series of pre-defined steps that should be followed to achieve a desired result. Therefore, a “surgical procedure” is synonymous with a “surgery.” See more: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm.

surgery
type: Class
subclass of: medical procedure
definition: Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery.
definition editor: YH, SS
alternative term: surgical procedure
definition source: WEB: http://en.wikipedia.org/wiki/Surgery
definition source: WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm
has_MedDRA_id: 10042609

surgery-induced pressure ulcer AE
type: Class
subclass of: surgery-induced adverse event
definition: a sugery adverse event that has an outcome of pressure ulcer.
definition editor: YH
alternative term: surgery-induced bedsore AE
alternative term: surgery-induced decubitus ulcer AE

metabolism, endocrine or exocrine system AE
type: Class
subclass of: adverse event
definition: an adverse event which occurs in a metabolism process (including anabolism and catabolism), endocrine system, or exocrine system.
definition editor: SS, YH, JX
alternative term: metabolism, endocrine, and exocrine system AE
has_MedDRA_id: 10027433
see also: MP: 0005266

clinical trial adverse event
type: Class
subclass of: adverse event
definition: an adverse event that occurs in clinical trial.
definition editor: YH

time at medical intervention
type: Class
subclass of: zero-dimensional temporal region
definition: a termporal instant that is the time when a medical intervention occurs.
definition editor: YH
alternative term: time instant of medical intervention

time instant of an adverse event outcome observed
type: Class
subclass of: zero-dimensional temporal region
definition: a temporal instant that is the time when an outcome of an adverse event (e.g., fever) is observed.
definition editor: YH

LAIV-induced adverse event
type: Class
subclass of: influenza vaccine-induced adverse event
definition: an influenza vaccine adverse event that is induced by a live attenuated influenza vaccine (LAIV).
definition editor: YH

FluMist-induced adverse event
type: Class
subclass of: LAIV-induced adverse event
subclass of: Restriction
  on property: induced_by
  some values from: VO_0000044
definition: an LAIV-induced adverse event that is caused by the FluMist LAIV.
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf

FluMist-induced runny nose AE
type: Class
subclass of: FluMist-induced adverse event
definition: a FluMist-induced adverse event that has an outcome of FluMist-induced runny nose
definition editor: YH

FluMist-induced nasal congestion AE
type: Class
subclass of: FluMist-induced adverse event
definition: a FluMist-induced AE that has an outcome of FluMist-induced nasal congestion
definition editor: YH

clinical laboratory test
type: Class
subclass of: OBI_0000011
definition: a planned process that is specifically a test conducted in a clinical laboratory.
definition editor: Rebecca Racz, Yongqun He
alternative term: medical laboratory test
definition source: WEB: http://labmed.ascpjournals.org/content/40/2/105.full

FluMist-induced sore throat AE in adult
type: Class
subclass of: FluMist-induced adverse event
subclass of: sore throat AE
definition: A FluMist-induced AE that has an outcome of sore throat
definition editor: YH
definition source: WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf

benign tumor AE
type: Class
subclass of: tumor AE
definition: a tumore AE that results in the outcome of a benign tumor.
creator: YH

malignant tumor AE
type: Class
subclass of: tumor AE
definition: a tumore AE that results in the outcome of a malignant tumor.
creator: YH

discomfort AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that resuls in an uncomfortable feeling.
definition editor: YH
see also: HPO: HP_0010832
see also: SIDER: C0234215

female reproductive system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0000474
subclass of: reproductive system AE
definition: a reproductive system AE that occurs on the female side.
definition editor: YH
has_MedDRA_id: 10038604

male reproductive system AE
type: Class
subclass of: reproductive system AE
definition: a reproductive system AE that occurs on the male side.
definition editor: YH

cardiac disorder AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0000948
subclass of: cardiovascular AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiovascular disorder AE that has a cardiac disorder outcome.
definition editor: SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/heart+disease Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23091623
has_MedDRA_id: 10007541
has_MedDRA_id: 10061024
see also: HPO: HP_0001627
see also: SIDER: C0018799

vascular disorder AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that has a vascular disorder outcome
has_MedDRA_id: 10047065

dermatitis AE
type: Class
subclass of: skin AE
definition: a skin adverse event that results in an inflammation of skin
definition editor: SS, YH
has_MedDRA_id: 10012431
see also: HPO: HP_0011123
see also: SIDER: C0011603

aspirin-induced adverse event
type: Class
subclass of: causal adverse drug event
definition: a drug adverse event that is induced by aspirin.
definition editor: YH
definition source: WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm

Aspidrox-induced adverse event
type: Class
subclass of: aspirin-induced adverse event
definition: an aspirin-induced adverse event that is induced by the aspirin drug Aspidrox.

aspirin-induced nausea AE
type: Class
equivalent class: Class
  intersection of: aspirin-induced adverse event
  intersection of: nausea AE
subclass of: aspirin-induced adverse event
subclass of: nausea AE
definition: an aspirin-induced adverse event that has an outcome of nausea
definition editor: YH
definition source: WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm

aspirin-induced vomiting AE
type: Class
equivalent class: Class
  intersection of: aspirin-induced adverse event
  intersection of: vomiting AE
subclass of: aspirin-induced adverse event
subclass of: vomiting AE
definition: an aspirin-induced adverse event that has an outcome of vomiting
definition editor: YH
definition source: WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm

aspirin-induced stomach pain AE
type: Class
subclass of: aspirin-induced adverse event
definition: an aspirin-induced adverse event that has an outcome of stomach pain
definition editor: YH
definition source: WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm

aspirin-induced heartburn AE
type: Class
subclass of: aspirin-induced adverse event
definition: an aspirin-induced adverse event that has an outcome of heartburn
definition editor: YH
definition source: WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm

aspirin-induced rash AE
type: Class
equivalent class: Class
  intersection of: aspirin-induced adverse event
  intersection of: rash AE
subclass of: aspirin-induced adverse event
subclass of: rash AE
definition: an aspirin-induced adverse event that has an outcome of rash symptom.
definition editor: YH
definition source: WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm

therapeutic intervention
type: Class
subclass of: medical intervention
definition: a medical intervention that is used for therapeutic purpose
definition editor: YH

causal adverse drug event
type: Class
equivalent class: Class
  intersection of: adverse drug event
  intersection of: Restriction
    on property: induced_by
    some values from: drug administration
subclass of: adverse drug event
definition editor: YH
definition editor: a drug adverse event that is caused by a drug adiministration. Here a causal effect is established between the drug administration and the adverse event.

adverse event induced by medical device
type: Class
equivalent class: Class
  intersection of: medical device adverse event
  intersection of: Restriction
    on property: induced_by
    some values from: medical device usage for medical intervention
subclass of: medical device adverse event
definition: a medical device adverse event that is induced or caused by a medical device. There is a causal relation between the adverse event and the usage of a medical device.
definition editor: YH

vaccine-induced adverse event
type: Class
equivalent class: Class
  intersection of: vaccine adverse event
  intersection of: Restriction
    on property: induced_by
    some values from: VO_0000002
subclass of: vaccine adverse event
definition: an adverse event that is induced by a vaccination.
definition editor: YH

surgery-induced adverse event
type: Class
equivalent class: Class
  intersection of: surgery adverse event
  intersection of: Restriction
    on property: induced_by
    some values from: surgery
subclass of: surgery adverse event
definition: a surgery adverse event that is caused by a surgery.
definition editor: YH

nutritional product-induced adverse event
type: Class
equivalent class: Class
  intersection of: nutritional product adverse event
  intersection of: Restriction
    on property: induced_by
    some values from: nutritional product usage
subclass of: nutritional product adverse event
definition editor: YH
definition editor: a nutritional product adverse event that has a causal assocition with the usage of the nutritional product.

influenza like illness AE
type: Class
subclass of: adverse event
definition: influenza like illness AE is an adverse event that has an outcome of a medical diagnosis of possible influenza or other illness causing a set of common symptoms
definition editor: SS, YH
alternative term: acute respiratory infection, ARI, flu-like syndrome
definition source: WEB: http://en.wikipedia.org/wiki/Influenza-like_illness
has_MedDRA_id: 10016791
see also: HPO: HP_0005376
see also: MDR: 10022004
see also: SIDER: C0521839

prediction of causal adverse event
type: Class
subclass of: OBI_0302910
definition: a prediction process that allows prediction of a causal adverse event induced by a medical intervention.
definition editor: YH

prediction of causal vaccine adverse event
type: Class
subclass of: prediction of causal adverse event
definition: a prediction of causal adverse event that is induced by a vaccination.
definition editor: YH

fungal infection AE
type: Class
subclass of: infection AE
definition editor: YH
definition editor: a pathogen infection adverse event that has an outcome of a fungal infection.
has_MedDRA_id: 10017533
see also: HPO: HP_0002841
see also: SIDER: C0026946

prediction of causal drug adverse event
type: Class
subclass of: prediction of causal adverse event
definition: a prediction of causal adverse event that is induced by a drug administration.
definition editor: YH

prediction of causal medical device adverse event
type: Class
subclass of: prediction of causal adverse event
definition: a prediction of causal adverse event that is induced by a usage of a medical device.
definition editor: YH

prediction of causal surgery adverse event
type: Class
subclass of: prediction of causal adverse event
definition: a prediction of causal adverse event that is induced by a surgery operation.
definition editor: YH

determination of causal adverse event
type: Class
subclass of: OBI_0000011
definition: a planned process that leads to the identification of a causal relation between an existing adverse event and a medical intervention.
definition editor: YH

determination of causal vaccine adverse event
type: Class
subclass of: determination of causal adverse event
definition: an identification of causal adverse event that is induced by a vaccination.
definition editor: YH

determination of causal drug adverse event
type: Class
subclass of: determination of causal adverse event
definition: an identification of causal adverse event that is induced by a drug administration.
definition editor: YH

determination of causal surgery adverse event
type: Class
subclass of: determination of causal adverse event
definition: an identification of causal adverse event that is induced by a surgery.
definition editor: YH

determination of causal medical device adverse event
type: Class
subclass of: determination of causal adverse event
definition: an identification of causal adverse event that is induced by a usage of a medical device.
definition editor: YH

intrinsic factor of causal adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition: an intrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event.
definition editor: YH

extrinsic factor of causal adverse event
type: Class
subclass of: extrinsic factor of adverse event
definition: an extrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event.
definition editor: YH

extrinsic factor of adverse event
type: Class
subclass of: role
definition: a role that is extrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include environment, diet, smoking, alcohol use, herbal product, drug-drug interaction.
definition editor: YH

intrinsic factor of adverse event
type: Class
subclass of: role
definition: a role that is intrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include: age, race, organ dysfunction, disease, pregrancy, lactation, gender, and genetics.
definition editor: YH

environment factor of adverse event
type: Class
subclass of: extrinsic factor of adverse event
definition editor: YH
definition editor: an extrinsic factor of adverse event that is from environment.

age factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is the age of a patient.

race factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is the race of a patient.

gender factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is the gender of a patient.

organ dysfunction factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is the organ dysfunction of a patient.

disease factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is a disease of a patient.

pregrancy factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is the pregrancy of a patient.

lactation factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is the lactation of a patient.

genetics factor of adverse event
type: Class
subclass of: intrinsic factor of adverse event
definition editor: YH
definition editor: an intrinsic factor of adverse event that is the genetics of a patient.

adverse event reporting
type: Class
subclass of: OBI_0000011
definition: a planned process that reports an adverse event.
definition editor: YH

vaccine adverse event reporting
type: Class
subclass of: adverse event reporting
definition: an adverse event reporting that is to report a vaccine adverse event.
definition editor: YH

drug adverse event reporting
type: Class
subclass of: adverse event reporting
definition: an adverse event reporting that is to report a drug adverse event.
definition editor: YH

a quality that represents the level of causality between a medical intervention and an adverse event outcome.
type: Class
subclass of: PATO_0001236
definition editor: YH
alternative term: adverse event causality
label: causality of adverse event

definite AE causality
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition editor: YH
definition editor: a causality level of AE that is definite.

probable AE causality
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition editor: YH
definition editor: a causality level of AE that is probable.

doubtful AE causality
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition editor: YH
definition editor: a causality level of AE that is doubtful.
alternative term: doubtful causality of adverse event

possible AE causality
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition editor: YH
definition editor: a causality level of AE that is possible.
alternative term: possible causality of adverse event
alternative term: potential causality of adverse event
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20.

medical device adverse event reporting
type: Class
subclass of: adverse event reporting
definition: an adverse event reporting that is to report a medical device adverse event.
definition editor: YH

surgery adverse event reporting
type: Class
subclass of: adverse event reporting
definition: an adverse event reporting that is to report a surgery adverse event.
definition editor: YH

determination of causal drug adverse event by Naranjo criteria
type: Class
subclass of: determination of causal drug adverse event
subclass of: Restriction
  on property: has_specified_input
  some values from: Naranjo criterium
subclass of: Restriction
  on property: has_specified_output
  some values from: Naranjo ADR probability score
definition: an identification of causal drug adverse event that is based on the Naranjo criteria.
definition editor: YH
definition source: S.R. Ahmed. Adverse drug event monitoring at the Food and Drug Administration. J. Gen. Intern. Med. 18 (2003) 57-60.

determination of causal drug adverse event by DIPS
type: Class
subclass of: determination of causal drug adverse event
subclass of: Restriction
  on property: has_specified_input
  some values from: DIPS question
subclass of: Restriction
  on property: has_specified_output
  some values from: DIPS score
definition: an identification of causal drug adverse event that is based on the Drug Interaction Probability Scale (DIPS). The DIPS uses a series of questions relating to the potential drug interaction to estimate a probability score. As a comparison, the Naranjo scale has proved to be useful for assessing the causality of adverse events, particularly for single-drug adverse drug reactions. DIPS involves in two drugs: the drug that is affected (object drug) and the drug that causes the change to the object drug (precipitant drug).
definition editor: YH
definition source: J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680.

DIPS question
type: Class
subclass of: information content entity
subclass of: Restriction
  on property: IAO_0000136
  some values from: DIPS score
definition: an information content entity that lists one of 10 questions for the Drug Interaction Probability Scale (DIPS).
definition editor: YH
definition source: J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680.

DIPS question 1
type: Class
subclass of: DIPS question
definition: DIPS question 1: Are there previous credible reports of this interaction in humans?
editor note: Three answers: Yes (+1), No (-1), and Unk or NA (0)
definition editor: YH

DIPS question 2
type: Class
subclass of: DIPS question
definition: DIPS question 2: Is the observed interaction consistent with the known interactive properties of precipitant drug?
editor note: Three answers: Yes (+1), No (-1), and Unk or NA (0)
definition editor: YH

DIPS question 3
type: Class
subclass of: DIPS question
definition: DIPS question 3: Is the observed interaction consistent with the known interactive properties of object drug?
editor note: Three answers: Yes (+1), No (-1), and Unk or NA (0)
definition editor: YH

DIPS question 4
type: Class
subclass of: DIPS question
definition: DIPS question 4: Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)?
editor note: Three answers: Yes (+1), No (-1), and Unk or NA (0)
definition editor: YH

DIPS question 5
type: Class
subclass of: DIPS question
definition: DIPS question 5: Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug? (if no dechallenge, use Unknown or NA and skip Question 6)
editor note: Three answers: Yes (+1), No (-2), and Unk or NA (0)
definition editor: YH

DIPS question 6
type: Class
subclass of: DIPS question
definition: DIPS question 6: Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug?
editor note: Three answers: Yes (+2), No (-1), and Unk or NA (0)
definition editor: YH

DIPS question 7
type: Class
subclass of: DIPS question
definition: DIPS question 7: Are there reasonable alternative causes for the event?
editor note: Three answers: Yes (-1), No (+1), and Unk or NA (0)
editor note: aConsider clinical conditions, other interacting drugs, lack of adherence, risk factors (eg, age, inappropriate doses of object drug). A NO answer presumes that enough information was presented so that one would expect any alternative causes to be mentioned. When in doubt, use Unknown or NA designation.
definition editor: YH

DIPS question 8
type: Class
subclass of: DIPS question
definition: DIPS question 8: Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction?
editor note: Three answers: Yes (+1), No (0), and Unk or NA (0)
definition editor: YH

DIPS question 9
type: Class
subclass of: DIPS question
definition: DIPS question 9: Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug (other than drug concentrations from question 8)?
editor note: Three answers: Yes (+1), No (0), and Unk or NA (0)
definition editor: YH

DIPS question 10
type: Class
subclass of: DIPS question
definition: DIPS question 10: Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased?
editor note: Three answers: Yes (+1), No (-1), and Unk or NA (0)
definition editor: YH

DIPS score
type: Class
subclass of: adverse event causality score
subclass of: Restriction
  on property: IAO_0000136
  some values from: causality based on DIPS score
definition: an AE causality score that is represented as a score of the Drug Interaction Probability Scale (DIPS).
editor note: Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2
definition editor: Yongqun He
alternative term: Drug Interaction Probability Scale
definition source: Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.

Naranjo criterium
type: Class
subclass of: information content entity
subclass of: Restriction
  on property: IAO_0000136
  some values from: Naranjo ADR probability score
definition editor: YH
definition editor: one of the Naranjo criteria that are frequently used for determination of causality for suspected adverse drug reactions (ADRs).
definition source: Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
definition source: WEB: http://livertox.nih.gov/Narajo.html

Naranjo criterium 1
type: Class
subclass of: Naranjo criterium
definition: DIPS question 1: Are there previous conclusive reports on this reaction?
editor note: Three answers: Yes (+1), No (0), and Don't Know (0)
definition editor: YH

Naranjo criterium 2
type: Class
subclass of: Naranjo criterium
definition: DIPS question 2: Did the adverse reaction appear after the suspected drug was administered?
editor note: Three answers: Yes (+2), No (-1), and Don't Know (0)
definition editor: YH

Naranjo criterium 3
type: Class
subclass of: Naranjo criterium
definition: DIPS question 3: Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?
editor note: Three answers: Yes (+1), No (0), and Don't Know (0)
definition editor: YH

Naranjo criterium 4
type: Class
subclass of: Naranjo criterium
definition: DIPS question 4: Did the adverse reaction reappear when the drug was readministered?
editor note: Three answers: Yes (+2), No (-1), and Don't Know (0)
definition editor: YH

Naranjo criterium 5
type: Class
subclass of: Naranjo criterium
definition: DIPS question 5: Are there alternative causes that could on their own have caused the reaction?
editor note: Three answers: Yes (-1), No (+2), and Don't Know (0)
definition editor: YH

Naranjo criterium 6
type: Class
subclass of: Naranjo criterium
definition: DIPS question 6: Did the reaction reappear when a placebo was given?
editor note: Three answers: Yes (-1), No (+1), and Don't Know (0)
definition editor: YH

Naranjo criterium 7
type: Class
subclass of: Naranjo criterium
definition: DIPS question 7: Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?
editor note: Three answers: Yes (+1), No (0), and Don't Know (0)
definition editor: YH

Naranjo criterium 8
type: Class
subclass of: Naranjo criterium
definition: DIPS question 8: Was the reaction more severe when the dose was increased or less severe when the dose was decreased?
editor note: Three answers: Yes (+1), No (0), and Don't Know (0)
definition editor: YH

Naranjo criterium 9
type: Class
subclass of: Naranjo criterium
definition: DIPS question 9: Did the patient have a similar reaction to the same or similar drug in any previous exposure?
editor note: Three answers: Yes (+1), No (0), and Don't Know (0)
definition editor: YH

Naranjo criterium 10
type: Class
subclass of: Naranjo criterium
definition: DIPS question 10: Was the adverse event confirmed by any objective evidence?
editor note: Three answers: Yes (+1), No (0), and Don't Know (0)
definition editor: YH

Naranjo ADR probability score
type: Class
subclass of: adverse event causality score
subclass of: Restriction
  on property: IAO_0000136
  some values from: causality based on Naranjo ADR probability scale
definition: a score of the Naranjo adverse drug reaction probability scaling
editor note: SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
definition editor: Yongqun He
definition source: Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
definition source: WEB: http://livertox.nih.gov/Narajo.html

causal adverse event probability
type: Class
subclass of: adverse event causality score
definition: an adverse event causal association score that represents a probability that an adverse event is caused (induced) by a medical intervention.
editor note: For an adverse event this is likely caused by a medical intervention, the causal adverse event (CAE) probabllity is in between 0 and 1. For a known causal adverse event, the CAE probabllity is 1. Alternatively, a CAE probability can be described as a scale that can go beyond the 0-1 range. For example, the Naranjo ADR probabililty score is a score that use scale with a wide range.
definition editor: YH
alternative term: CAE probability

sensory neuropathy AE
type: Class
subclass of: neuropathy AE
definition: a peripheral neuropathy AE which has an outcome of sensory neuropathy that involves damage to nerves of the peripheral nervous system.
definition editor: YH, AG
alternative term: sensory neuropathy AE

distal sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
definition: a sensory neuropathy AE which has an outcome of distal sensory neuropathy that involves damage to distal sensory nerves of the peripheral nervous system.
definition editor: YH, AG

chronic distal sensory neuropathy AE
type: Class
subclass of: distal sensory neuropathy AE
definition: a distal sensory neuropathy AE that is chronic.
definition editor: YH, AG

drug-induced neuropathy AE
type: Class
equivalent class: Class
  intersection of: causal adverse drug event
  intersection of: neuropathy AE
subclass of: neuropathy AE
definition: a neuropathy AE that is induced by a drug administration
definition editor: AG, YH
definition source: https://medlineplus.gov/ency/article/000700.htm

tremor AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002385
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Tremor AE is a behavior and neurological AE that has an outcome of an involuntary trembling or quivering, and muscle contraction and relaxation.
definition editor: SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/tremor.html
has_MedDRA_id: 10044565
see also: CTCAE: E12837
see also: HPO: HP_0001337
see also: NCIt: C38038
see also: SIDER: C0040822

autonomic neuropathy AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002410
subclass of: neuropathy AE
definition: a neuropathy AE which shows symptoms due to the damage to the autonomic nerves. This damage disrupts signals between the brain and portions of the autonomic nervous system, such as the heart, blood vessels and sweat glands. This can cause decreased or abnormal performance of one or more involuntary body functions.
definition editor: AG, YH
definition source: WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/autonomic-neuropathy/basics/definition/con-20029053
has_MedDRA_id: 10061666
see also: HPO: HP_0002270
see also: SIDER: C0259749
see also: UMLS CUI: C0259749

motor neuropathy AE
type: Class
subclass of: neuropathy AE
definition: a peripheral neuropathy AE which is caused by a damage to motor neurons
definition editor: AG, YH

polyneuropathy AE
type: Class
subclass of: neuropathy AE
definition: A peripheral neuropathy AE which is characterized by damage to more than one nerve
definition editor: AG, YH, RR
definition source: WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html
has_MedDRA_id: 10036105
see also: HPO: HP_0001271
see also: SIDER: C0152025

mononeuropathy AE
type: Class
subclass of: neuropathy AE
definition: a neuropathy AE which is characterized by isolated damage of a single nerve
definition editor: AG, YH
has_MedDRA_id: 10062203

distal neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
definition: a peripheral neuropathy AE which affects extremities, such as, toes, fingers, hand and feet.
definition editor: AG, YH
alternative term: axonal neuropathy AE
definition source: WEB: http://www.livestrong.com/article/184686-distal-neuropathy-symptoms/

neuronopathy AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that affects the neuronal cell body
definition editor: AG, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922643/

mononeuritis AE
type: Class
subclass of: neuritis AE
definition: A neuritis AE which has an outcome of mononeuritis characterized by isolated inflammation of one nerve.
definition editor: AG, YH
has_MedDRA_id: 10027910

polyneuritis AE
type: Class
subclass of: neuritis AE
definition: A neuritis AE which has an outcome of polyneuritis characterized by isolated inflammation of many nerves.
definition editor: AG, YH

mononeuritis multiplex AE
type: Class
subclass of: mononeuritis AE
definition: a mononeuritis AE which has an outcome of mononeuritis multiplex which involves damage to at least two seperate unrelated nerve area.
definition editor: AG, YH

acute sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
definition: a sensory neuropathy AE which has an outcome of acute sensory neuropathy that is characterized by rapid onset
definition editor: AG, YH

AE risk factor
type: Class
subclass of: disposition
definition: a disposition that represents a risk factor associated with the occurrence of an adverse event.
definition editor: AG, YH

AE incidence rate
type: Class
subclass of: data item
definition: A data item that is calculated as the number of patients realized with an adverse event beginning in an interval divided by the number of patients taking the same medical intervention within the same interval. The incidence thus indicates the number of newly occurring events over time.
definition editor: AG, YH
definition source: WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf

causal adverse drug event due to drug-drug interaction
type: Class
subclass of: causal adverse drug event
definition: a causal adverse drug event that is induced by a drug-drug interaction.
definition editor: YH, LT
definition source: WEB: http://medical-dictionary.thefreedictionary.com/drug+interaction
has_MedDRA_id: 10013710

causal adverse drug event due to food-drug interaction
type: Class
subclass of: causal adverse drug event
definition: a causal adverse drug event that is induced by a food-drug interaction.
definition editor: YH, LT

causal adverse drug event due to genetic predisposition
type: Class
subclass of: causal adverse drug event
definition: a causal adverse drug event that is induced bygenetic predisposition.
definition editor: YH, LT

causal adverse drug event due to SNP
type: Class
subclass of: causal adverse drug event due to genetic predisposition
definition: a causal adverse drug event due to genetic predisposition that is specifically induced by SNP.
definition editor: YH, LT

circulatory shock AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that is a result of insufficient blood flow throughout the body. Shock often accompanies severe injury or illness.
alternative term: physiological shock AE
alternative term: shock
definition source: WEB: http://en.wikipedia.org/wiki/Shock_%28circulatory%29
definition source: WEB: http://njcc.nl/sites/default/files/pdf/review-2_1.pdf (Lima A. Circulatory shock and peripheral circulatory failure: a historical perspective. Netherlands Journal of Critical Care. 2014. 18:6. 14-18)
definition source: WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000039.htm
Chinese translation: 休克
has_MedDRA_id: 10040560
comment: Circulatory shock is not related to the emotional state of shock.
comment: Here is the Kumar and Parrilo definition of shock: "The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury". Reference: Kumar A, Parillo JE. Shock: pathophysiology, classification and approach to management. In: Parrillo JE, Parrillo JE, Bone RC (eds): Critical care medicine: Principles of diagnosis and management. Mosby: Toronto, 1995, pp 371-420.

dementia AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that has an outcome of a loss of brain function and causes a long term and often gradual decrease in the ability to think and remember such that a person's daily functioning is affected.
definition editor: YH, MW
definition source: WEB: https://en.wikipedia.org/wiki/Dementia
Chinese translation: 痴呆
has_MedDRA_id: 10012272
comment: Dementia is a loss of brain function that occurs with certain diseases or pathological processes.
see also: HPO: HP_0000726
see also: SIDER: C0497327

thrombosis AE
type: Class
subclass of: vascular disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001981
definition: A vascular disorder AE that results in the presence of blood clot along the wall of a blood vessel, frequently causing vascular obstruction. Some authorities differentiate thrombus formation from simple coagulation or clot formation.
definition editor: SS, YH, MW
Chinese translation: 血栓症; 血栓生成
has_MedDRA_id: 10043607
see also: HPO: HP_0004419
see also: SIDER: C0040053

cell death AE
type: Class
subclass of: metabolic disorder AE
definition: a metabolic disorder AE that has an outcome of cell death.
definition editor: SS, YH
has_MedDRA_id: 10057248
see also: GO: GO_0008219
see also: SIDER: C0007587

respiratory tract neoplasm AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE which has an outcome of some respiratory tract neoplasm.
definition editor: YH
has_MedDRA_id: 10029107

competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A
type: Class
subclass of: role

biochemical inhibitor role
type: Class
subclass of: role
definition editor: YH, AG, YL

agonist role
type: Class
subclass of: role
definition editor: YH, AG, YL
definition source: WEB: http://en.wikipedia.org/wiki/Agonist

antagonist role
type: Class
subclass of: role
definition editor: YH, AG, YL
definition source: WEB: http://en.wikipedia.org/wiki/Receptor_antagonist
comment: In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors.

phlebitis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001638
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an inflammation AE that shows the result of an inflammation located in a vein, usually in the legs.
definition editor: YH, MW
has_MedDRA_id: 10034879
see also: HPO: HP_0004419
see also: SIDER: C0031542

pancreatitis AE
type: Class
subclass of: hepatobiliary or pancreatic AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001264
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a liver, biliary, and pancreatic AE that has an outcome of pancreatitis.
definition editor: YH, MW
has_MedDRA_id: 10033645
has_MedDRA_id: 10033646
see also: CTCAE: E10930
see also: HPO: HP_0001733
see also: NCIt: C3306
see also: SIDER: C0030305

apoptosis AE
type: Class
subclass of: cell death AE
subclass of: Restriction
  on property: has part
  some values from: OAE_0004522
definition: a cell death AE that has an outcome of apoptosis, a form of programmed cell death that occurs in multicellular organisms.
definition editor: SS, YH
definition source: https://en.wikipedia.org/wiki/Apoptosis
has_MedDRA_id: 10059512

necrosis AE
type: Class
subclass of: cell death AE
subclass of: Restriction
  on property: has participant undergoing
  some values from: necrotic cell death
definition: a cell death AE that has an outcome of necrosis
definition editor: SS, YH
see also: HPO: HP_0003713
see also: SIDER: C0027540

ischemia AE
type: Class
subclass of: cardiovascular AE
definition: A cardiovascular disorder AE that results in Insufficient blood supply for the need of a part of the body, usually as a result of a disease of the blood vessels supplying that part.
definition editor: SS, YH
alternative term: ischaemia AE
has_MedDRA_id: 10061255
comment: Note: also spelt ischemia.
see also: HPO: HP_0002597
see also: SIDER: C0022116

hair, skin or nail AE
type: Class
equivalent class: Class
  union of: hair AE
  union of: nail AE
  union of: skin AE
subclass of: adverse event
definition: an adverse event that occurs in hair, skin, or nail.
alternative term: hair, skin, and nail AE
creator: YH, SS, JX

hair AE
type: Class
subclass of: hair, skin or nail AE
definition: a hair, skin, and nail AE that occurs in hair.
definition editor: YH, SS

nail AE
type: Class
subclass of: hair, skin or nail AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001705
definition: a hair, skin, and nail AE that occurs in nail.
definition editor: YH, SS

endocrine system AE
type: Class
subclass of: metabolism, endocrine or exocrine system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000949
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a metabolism, endocrine, and exocrine system AE that occurs in endocrine system.
has_MedDRA_id: 10014698
creator: YH, SS

exocrine system AE
type: Class
subclass of: metabolism, endocrine or exocrine system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002330
definition: a metabolism, endocrine, and exocrine system AE that occurs in exocrine system
creator: YH, SS

congenital AE
type: Class
subclass of: adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an adverse event that displays a congential and genetic disorder.
alternative term: congenital abnormality AE
has_MedDRA_id: 10010331
creator: YH, SS

paresis AE
type: Class
subclass of: movement disorder AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002385
definition: a muscular weakness AE that shows weakness or inability to move a body part, often used to describe a neurologic condition.
definition source: WEB: https://en.wikipedia.org/wiki/Paresis
Chinese translation: 局部麻痹
has_MedDRA_id: 10033800
comment: Neurologists use the term paresis to describe weakness, and plegia to describe paralysis in which all voluntary movement is lost. (Reference: https://en.wikipedia.org/wiki/Paresis)
see also: HPO: HP_0008153
see also: SIDER: C0030552

cystic fibrosis AE
type: Class
subclass of: syndrome AE
definition: a syndrome AE that has an outcome of cystic fibrosis, an inherited disease that affects the lungs, digestive system, sweat glands, and male fertility.
definition editor: YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cystic+fibrosis
has_MedDRA_id: 10011762
see also: HPO: HP_0006552
see also: SIDER: C0010674

hyperplasia AE
type: Class
subclass of: tumor AE
definition: a tumore AE that results in the outcome of hyperplasia, an abnormal increase in the number of normal cells in normal arrangement in an organ or tissue, which increases its volume.
creator: YH, SS
see also: HPO: HP_0010279
see also: SIDER: C0020507

abdominal AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: Class
    union of: UBERON_0000916
    union of: UBERON_0005172
subclass of: adverse event
definition: an adverse event that displays a disorder in abdomen.
creator: YH, SS

genetic AE
type: Class
subclass of: adverse event
definition: an adverse event that results in genetic disorder.
alternative term: genetic disorder AE
creator: YH, SS

hepatitis AE
type: Class
subclass of: liver inflammation AE
definition: a liver, biliary, and pancreatic AE that has an outcome of hepatitis.
definition editor: YH
see also: HPO: HP_0006562
see also: SIDER: C0019158

ulcer AE
type: Class
subclass of: adverse event
definition: an adverse event that displays an outcome of ulcer.
creator: YH, SS
see also: HPO: HP_0005229
see also: SIDER: C0041582

fistula AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body.
definition source: WEB: http://medical-dictionary.thefreedictionary.com/fistula
has_MedDRA_id: 10067143
creator: YH, SS
see also: HPO: HP_0010294
see also: SIDER: C0016169

extravasation AE
type: Class
subclass of: abnormal fluid regulation AE
definition: an abnormal fluid regulation AE which has an outcome of extravasation, a discharge or escape, as of blood, from a vessel into the tissues.
definition editor: YH, SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/extravasation
has_MedDRA_id: 10015866

sclerosis AE
type: Class
subclass of: adverse event
definition: an adverse event that displays an outcome of an sclerosis, the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue.
creator: YH, SS

inconsolable crying AE
type: Class
subclass of: crying abnormal AE
definition: a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient
definition editor: YH
has_MedDRA_id: 10065283

unusual high-pitched crying AE
type: Class
subclass of: crying abnormal AE
definition: a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient
definition editor: YH

prolonged crying AE
type: Class
subclass of: crying abnormal AE
definition: a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient
definition editor: YH

bradycardia AE
type: Class
subclass of: decreased heart rate AE
definition: a decreased heart rate AE that results in a resting heart rate of under 60 beats per minutes (BPM).
definition source: WEB: http://en.wikipedia.org/wiki/Bradycardia
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bradycardia
has_MedDRA_id: 10006093
see also: HPO: HP_0001662
see also: SIDER: C0428977

prenatal, perinatal or neonatal disorder AE
type: Class
subclass of: adverse event
definition: an adverse event that displays a disorder associated with child birth, newborn infant, or an infant.
alternative term: pregnancy, neonatal and perinatal disorder AE
has_MedDRA_id: 10036585
creator: YH, JX

administration of ineffective drug
type: Class
subclass of: errored drug administration
definition: an errored drug administration where a patient is administered with an ineffective drug
definition editor: YH

administration of drug with decreased effectiveness
type: Class
subclass of: errored drug administration
definition: an errored drug administration where a patient is administered with an ctive drug with decreased effectiveness
definition editor: YH

aplenzin-induced adverse event
type: Class
subclass of: bupropion-induced adverse event
definition: a bupropion-induced adverse event that is induced by aplenzin administration
definition editor: YH

drug overdose administration
type: Class
subclass of: errored drug administration
definition: an errored drug administration where a patient is administered with a drug above the therapeutic level
definition editor: YH

administration of drug with omitted dose
type: Class
subclass of: errored drug administration
definition: an errored drug administration where a patient is administered with an drug without knowing the dose used.
definition editor: YH

drug resistance
type: Class
subclass of: quality
definition: a quality that represents resistance of a patient to a drug.
definition editor: YH

medical intervention site AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: occurs in
    some values from: medical intervention site
subclass of: adverse event
definition: an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site).
definition editor: YH
alternative term: application site reaction
has_MedDRA_id: 10003055

medical intervention site
type: Class
subclass of: site
definition: a site that is used for a medical intervention
definition editor: YH

administration of drug stored in capsule with physical defect
type: Class
subclass of: errored drug administration
definition: an errored drug administration where a patient is administered with an drug stored in capsule with physical defect
definition editor: YH

administration of drug with wrong technique
type: Class
subclass of: errored drug administration
definition: an errored drug administration where a patient is administered with an drug with wrong technique
definition editor: YH
has_MedDRA_id: 10064353

administration of drug with incorrect route
type: Class
subclass of: administration of drug with wrong technique
definition: a drug administration where a patient is administered with an drug with incorrect route
definition editor: YH
has_MedDRA_id: 10064304

neonatal AE
type: Class
subclass of: prenatal, perinatal or neonatal disorder AE
subclass of: Restriction
  on property: happens during
  some values from: UBERON_0007221
definition: A pregnancy, neonatal and perinatal AE that displays a disorder associated with newborn infant or an infant.
creator: YH

perinatal AE
type: Class
subclass of: prenatal, perinatal or neonatal disorder AE
subclass of: Restriction
  on property: happens during
  some values from: UBERON_0012101
definition: A pregnancy, neonatal and perinatal AE that displays a disorder associated with childbirth
creator: YH

errored medication
type: Class
subclass of: medical intervention
definition: a medical intervention that has an errored medication
definition editor: YH
has_MedDRA_id: 10027091

errored drug administration
type: Class
subclass of: errored medication
definition: a medical intervention that has errored drug medication
definition editor: SS, YH
has_MedDRA_id: 10064355

radiotherapy
type: Class
subclass of: therapeutic intervention
definition: a therapeutic intervention that uses radiation
definition editor: YH

arterial disorder AE
type: Class
subclass of: vascular disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: a vascular disorder AE that affects the artery
definition editor: SS
alternative term: arterial disease AE
see also: HPO: HP_0002620
see also: SIDER: C0852949

peripheral arterial disease AE
type: Class
subclass of: arterial disorder AE
definition: an artery disorder AE that is characterized by a narrowing of the blood vessels outside of the heart.
definition editor: SS
alternative term: peripheral artery disease AE
alternative term: peripheral artery disorder AE
definition source: WEB: http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=peripheral+arterial+disease
has_MedDRA_id: 10067825
see also: HPO: HP_0004950
see also: SIDER: C1704436

psoriasis AE
type: Class
subclass of: autoimmune disorder AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002097
definition: an autoimmune disease AE that shows a symptom of dry red patches on the skin.
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/psoriasis
definition source: WEB: https://en.wikipedia.org/wiki/Psoriasis
has_MedDRA_id: 10037153
see also: HPO: HP_0003765
see also: SIDER: C0033860

cumulative distal sensory neuropathy AE
type: Class
subclass of: distal sensory neuropathy AE
definition: a distal sensory neuropathy AE characterized by an increase in degree (cumulative)
definition editor: AG, YH

stress AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of stress in a patient
definition editor: YH

abdominal abscess AE
type: Class
subclass of: abscess AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition: an abscess AE that has an outcome of a pocket of infected fluid and pus located inside the abdominal cavity
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000212.htm
has_MedDRA_id: 10060921

abdominal discomfort AE
type: Class
subclass of: discomfort AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000916
definition: a discomfort AE that has an outcome of a stomach ache
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Abdominal+discomfort
has_MedDRA_id: 10000059
see also: HPO: HP_0002027
see also: SIDER: C0232487

abdominal distension AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sensory capability AE that results in a sensation of elevated abdominal pressure and volume
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0003609/
has_MedDRA_id: 10000060
see also: CTCAE: E10456
see also: HPO: HP_0003270
see also: NCIt: C78161
see also: SIDER: C0000731

abdominal sepsis AE
type: Class
subclass of: sepsis AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition: a sepsis AE that has an outcome of sepsis in the abdominal area
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001687/
has_MedDRA_id: 10058040

abdominal wall abscess AE
type: Class
subclass of: abdominal abscess AE
definition: an abdominal abscess AE that has an outcome of a collection of pus in the abdominal wall, causes inflammation
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002329/
has_MedDRA_id: 10000099

obsolete: behavior AE
type: Class
subclass of: ObsoleteClass
definition: a behavioral AE that results in uncharacteristic behaviors
editor note: 12/19/2015: This term became obsolete since its meaning can be quite confusing. "behavior AE" is now considered as the synonym of 'behavioral and neurological AE'.
definition editor: DJ, SS, YH
alternative term: abnormal behavior AE
alternative term: abnormal behaviour AE
alternative term: behavioral AE
has_MedDRA_id: 10061422
see also: HPO: HP_0000708
see also: SIDER: C0233514

abnormal dreams AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavioral and neurological AE that results in odd dreams
definition editor: DJ, SS, YH
has_MedDRA_id: 10000125

abortion induced AE
type: Class
equivalent class: Class
  intersection of: abortion AE
  intersection of: Restriction
    on property: induced_by
    some values from: medical intervention
subclass of: abortion AE
definition: an abortion AE that has an outcome of expulsion of a fetus from the uterus brought on intentionally by medication or instrumentation
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/induced+abortion
has_MedDRA_id: 10000220

abortion spontaneous AE
type: Class
subclass of: abortion AE
definition: an abortion AE that results in a miscarriage
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002458/
has_MedDRA_id: 10000234
see also: HPO: HP_0005268
see also: SIDER: C0000786

acne AE
type: Class
subclass of: skin AE
definition: a skin AE that is characterized by pimples generally on the face, chest and back, caused by clogging of the pores
definition editor: DJ, SS, YH
alternative term: acne vulgaris AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/acne
has_MedDRA_id: 10000496
see also: HPO: HP_0001061
see also: SIDER: C0702166

acquired immunodeficiency syndrome AE
type: Class
subclass of: immune system AE
definition: a immune system disorder AE that is caused by the HIV virus
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/hivaids.html
has_MedDRA_id: 10000565
see also: HPO: HP_0002721
see also: SIDER: C0001175

activated partial thromboplastin time prolonged AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a hematopoietic system AE that has an outcome of a prolonged time taken for blood to clot. The partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. PTT measures the efficacy of the comon coagulation pathways and helps tell if bleeding or clotting problems exist.
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm
has_MedDRA_id: 10000636
see also: CTCAE: E12073
see also: HPO: HP_0003645
see also: NCIt: C27028
see also: SIDER: C0853223

acute graft versus host disease in intestine AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the intestine attack the transplant recipient's body
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
has_MedDRA_id: 10066264

acute graft versus host disease in skin AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the skin attack the transplant recipient's body
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
has_MedDRA_id: 10066262

acute lymphocytic leukemia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of a type of acute leukemia, characterized by anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, and bone pain
definition editor: DJ, SS, YH
alternative term: acute lymphocytic leukaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Blast+count
has_MedDRA_id: 10000846
see also: HPO: HP_0006721
see also: SIDER: C0023449

acute lymphocytic leukemia recurrent AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of the reoccurance of fast-growing cancer of the white blood cells where abnormal blasts do not fight infections after a period of remission
definition editor: DJ, SS, YH
alternative term: acute lymphocytic leukaemia recurrent AE
definition source: WEB: http://marrow.org/Patient/Disease_and_Treatment/About_Your_Disease/ALL/Acute_Lymphoblastic_Leukemia_(ALL).aspx
has_MedDRA_id: 10063620

acute myeloid leukemia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of cancer in the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells
definition editor: DJ, SS, YH
alternative term: acute myeloid leukaemia AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/
has_MedDRA_id: 10000880
see also: HPO: HP_0004808
see also: SIDER: C0023467

acute myeloid leukemia recurrent AE
type: Class
subclass of: tumor AE
definition: an acute myeloid leukemia AE that shows an recurrence of acute myeloid leukemia
definition editor: DJ, SS, YH
alternative term: acute myeloid leukaemia recurrent AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/
has_MedDRA_id: 10059034

acute pulmonary edema AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has the outcome fluid accumulation in the air spaces and parenchyma of the lungs with rapid onset
definition editor: DJ, SS, YH
alternative term: acute pulmonary oedema AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Acute+pulmonary+edema
has_MedDRA_id: 10001029
see also: HPO: HP_0100598
see also: SIDER: C0155919

acute respiratory distress syndrome AE
type: Class
subclass of: respiratory distress AE
definition: a respiratory distress AE that prevents enough oxygen from getting to the lungs and into the blood
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001164/
has_MedDRA_id: 10001052
see also: HPO: HP_0002093
see also: SIDER: C0035222

acute respiratory failure AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of a condition in which not enough oxygen passes from the lungs into the blood, with rapid onset
definition editor: DJ, SS, YH, MW
definition source: WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/rf/
has_MedDRA_id: 10001053
see also: HPO: HP_0002093
see also: SIDER: C0264490

adams-stokes syndrome AE
type: Class
subclass of: syncope AE
definition: a syncope AE that results in sudden episodes of fainting and sometimes seizures
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518479/
has_MedDRA_id: 10001115

adenomyosis AE
type: Class
subclass of: reproductive system AE
definition: a reproductive system AE that results in the thickening of the walls of the uterus. This ccurs when endometrial tissue, which normally lines the uterus, moves into the outer muscular walls of the uterus.
definition editor: DJ, SS, YH
alternative term: endrometriosis interma AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002481/
has_MedDRA_id: 10056268

adenovirus infection AE
type: Class
subclass of: viral infection AE
definition: a viral infection that occurs in the respiratory system and has an outcome of viral infection by nonenveloped icosahedral viruses causing illness in the respiratory system
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Adenovirus+Infections
has_MedDRA_id: 10060931
see also: HPO: HP_0004429
see also: SIDER: C0001486

adrenal neoplasm AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002113
definition: a tumor AE that results in an abnormal number of cells proliferating on the kidney(s)
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22486993
has_MedDRA_id: 10061588

adrenal suppression AE
type: Class
subclass of: endocrine system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002369
definition: an endocrine system AE that results in the suppression of the functions of the adrenal glands
definition editor: DJ, SS, YH
has_MedDRA_id: 10001382

aggression AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in an increase in hostile behavior
definition editor: DJ, SS, YH
has_MedDRA_id: 10001488
see also: HPO: HP_0000718
see also: SIDER: C0001807

agranulocytosis AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of acute leukopenia, or lowered white blood cell count, most commonly of neutrophils causing neutropenia in circulating blood
definition editor: JX, DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001295.htm
Chinese translation: 粒性白血球缺乏症
has_MedDRA_id: 10001507
see also: HPO: HP_0001913
see also: SIDER: C0001824

air embolism AE
type: Class
subclass of: embolism AE
definition: an embolism AE that is caused by an air bubble in the vessel
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23295634
has_MedDRA_id: 10001526

alanine aminotransferase level abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a liver related investigation result abnormal AE that has an outcome of an abnormal blood level of alanine aminotransferase
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615
has_MedDRA_id: 10001547

alanine aminotransferase level decreased AE
type: Class
subclass of: alanine aminotransferase level abnormal AE
definition: an alanine aminotransferase level abnormal AE that has an outcome of a decrease in alanine aminotransferase level in body
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615
has_MedDRA_id: 10001549

alanine aminotransferase level increased AE
type: Class
subclass of: alanine aminotransferase level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: an alanine aminotransferase level abnormal AE that has an outcome of elevated levels of alanine transaminase, an enzyme most commonly found in the liver
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615
has_MedDRA_id: 10001551
see also: CTCAE: E12077
see also: NCIt: C26948

alcoholic liver disease AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE that is characterized by liver disease caused by the patient's alcoholic activity
definition editor: DJ, SS, YH
has_MedDRA_id: 10001627

altered state of consciousness AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of significantly different waking beta wave state
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/20182997
has_MedDRA_id: 10001854

amenorrhoea AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that is characterized by the absence of menstrual period in a woman of reproductive age
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21942684
has_MedDRA_id: 10001928
see also: HPO: HP_0000141
see also: SIDER: C0002453

amniotic fluid volume decreased AE
type: Class
subclass of: abnormal fluid regulation AE
definition: an abnormal fluid regulation AE that results in a decreased volume of amniotic fluid during pregnancy
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22039031
has_MedDRA_id: 10063356

anal fissure AE
type: Class
subclass of: OAE_0004229
definition: an anus AE that has an outcome of a split or tear in the mucosa lining the lower rectum
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002116/
has_MedDRA_id: 10002153
see also: HPO: HP_0004378
see also: SIDER: C0016167

anal ulcer AE
type: Class
subclass of: ulcer AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001245
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an ulcer AE that has an outcome of an ulcer in the anal cavity
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/17073250
has_MedDRA_id: 10002180
see also: CTCAE: E10496
see also: NCIt: C79536

anastomotic leak AE
type: Class
subclass of: vascular disorder AE
definition: a vascular disorder AE that has an outcome of a leakage at the site of the intersection of two blood vessels
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23122582
has_MedDRA_id: 10050456

angina pectoris AE
type: Class
subclass of: angina AE
subclass of: Restriction
  on property: is evidence of
  some values from: prinzmetal angina AE
definition: a cardiac disorder AE that is stable and shows the symptom of a chest pain due to ischemia of the heart
definition editor: DJ, SS, YH
alternative term: stable angina AE
definition source: WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Angina-Pectoris-Stable-Angina_UCM_437515_Article.jsp#
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723
has_MedDRA_id: 10002383
see also: HPO: HP_0001681
see also: SIDER: C0002962

angina unstable AE
type: Class
subclass of: angina AE
definition: a angina AE that is unstable and has an outcome of a condition in which the heart doesn't get enough blood flow through the blood vessels of the heart muscle, may lead to heart attack.
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001250/
has_MedDRA_id: 10002388
see also: HPO: HP_0001681
see also: SIDER: C0002965

antiphospholipid antibodies positive AE
type: Class
subclass of: immunology and allergy investigation result abnormal AE
definition: an immunology and allergy investigation result abnormal AE that is characterized by antibodies present that are against cell-membrane phospholipids that provoke blood clots
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23231732
has_MedDRA_id: 10048678

anuria AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE that has an outcome of the absence of urine formation
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/anuria
has_MedDRA_id: 10002847
see also: HPO: HP_0100519
see also: SIDER: C0003460

aortic disorder AE
type: Class
subclass of: vascular disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000947
definition: a vascular disorder AE that results in a condition affecting the aorta and aortic valves
definition editor: DJ, SS, YH
definition source: WEB: http://www.rightdiagnosis.com/medical/aorta_disorder.htm
has_MedDRA_id: 10058648
see also: HPO: HP_0001679
see also: SIDER: C0003493

aortic valve incompetence AE
type: Class
subclass of: cardiac valve disease AE
definition: a cardiac valve disease AE that has an outcome of inability of the aortic valve to function effectively
definition editor: DJ, SS, YH
definition source: WEB: http://www.rightdiagnosis.com/a/aortic_valve_incompetence/intro.htm
has_MedDRA_id: 10002915
see also: HPO: HP_0001659
see also: SIDER: C0003504

aplasia AE
type: Class
subclass of: congenital AE
definition: a congenital abnormality AE with an outcome of defective development or congenital absense of an organ or tissue
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/737831
has_MedDRA_id: 10002961
see also: HPO: HP_0010515
see also: SIDER: C0243065

aplastic anaemia AE
type: Class
subclass of: anemia AE
definition: Aplastic anaemia AE is an anemia AE that occurs when the bone marrow, and the blood stem cells that reside there are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia).
definition editor: DJ, SS, JX, YH
alternative term: aplastic anemia
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23292240
Chinese translation: 再生障碍性贫血
has_MedDRA_id: 10002967
see also: HPO: HP_0001915
see also: SIDER: C0002874

allergic brochospasm AE that requires treatment in emergency
type: Class
subclass of: serious adverse event
definition: a serious AE that is due to an allergic brochospasm, which causes a serious problem with breathing and requires treatment in an emergency room.
definition editor: YH, JX
definition source: URL: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: URL: https://en.wikipedia.org/wiki/Bronchospasm

application site hypersensitivity AE
type: Class
subclass of: hypersensitivity AE
definition: a hypersensitivity AE that occurs at the site of an application of a medical intervention (e.g., drug administration or vaccination).
definition editor: DJ, SS, YH
has_MedDRA_id: 10063683

application site infection AE
type: Class
subclass of: infection AE
definition: an infection AE that occurs at the site of drug application
definition editor: DJ, SS, YH
has_MedDRA_id: 10049041

arterial hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: a hemorrhage AE that has an outcome of bleeding in the arteries
definition editor: DJ, SS, YH
alternative term: arterial bleeding AE
alternative term: arterial haemorrhage AE
has_MedDRA_id: 10060964

CSF protein increased AE
type: Class
subclass of: abnormal cerebrospinal fluid production AE
definition: CSF protein increased AE is an abnormal cerebrospinal fluid production that results in and increase in blood level CSF protein
definition editor: SS, YH
has_MedDRA_id: 10011575

CSF test result abnormal AE
type: Class
subclass of: behavioral and neurological test abnormal AE
definition: a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of an abnormal result in the cerebrospinal fluid (CSF) collection test that examines the fluid that surrounds the brain and spinal cord
editor note: This should be inferred as a "AE: lab test abnormal".
definition editor: SS, YH, EB
definition source: WEB: www.nlm.nih.gov/medlineplus/ency/article/003428.htm
has_MedDRA_id: 10059703

Henoch-Schonlein purpura AE
type: Class
subclass of: purpura AE
definition: Henoch-Schonlein purpura AE is a purpura AE, a systemic vasculitis (inflammation of blood vessels) characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney. This results from some allergic response,
definition editor: SS, YH
alternative term: allergic purpura, anaphylactoid purpura, vascular purpura
definition source: WEB: http://en.wikipedia.org/wiki/Henoch-Schonlein_purpura
has_MedDRA_id: 10019617
see also: HPO: HP_0000979
see also: SIDER: C0034152

abasia AE
type: Class
subclass of: movement disorder AE
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Abasia
has_MedDRA_id: 10049460
comment: a movement disorder AE that has an outcome of abasia, a movement disorder that results in and inability to walk due to impaired muscle coordination
see also: HPO: HP_0002540
see also: SIDER: C0877217

abdominal pain upper AE
type: Class
subclass of: OAE_0003346
definition: a stomach pain AE that is observed in upper stomach
definition editor: SS, YH
has_MedDRA_id: 10000087
see also: HPO: HP_0002027
see also: SIDER: C0232492

ageusia AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of loss of taste functions of the tongue, particularly the inability to detect sweetness, sourness, bitterness, saltiness, and umami (the taste of monosodium glutamate).
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Ageusia
has_MedDRA_id: 10001480

chronic sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
definition: a sensory neuropathy AE that has an outcome of chronic sensory neuropathy characterized by being persistent or long-lasting in nature
definition editor: AG, YH

anosmia AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of a lack of functioning olfaction, an inability to perceive odors
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Olfaction
has_MedDRA_id: 10002653
see also: HPO: HP_0010632
see also: SIDER: C0003126

anxiety AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has an outcome of a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Anxiety
has_MedDRA_id: 10002855
see also: CTCAE: E12883
see also: HPO: HP_0000739
see also: NCIt: C26696
see also: SIDER: C0003467

atrial flutter AE
type: Class
subclass of: arrhythmia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an arrhythmia AE that is characterized by rapid regular atrial contractions occurring usually at rates between 250 and 400 per minute and often producing saw-tooth waves in an electrocardiogram.
definition editor: SS
alternative term: AF
alternative term: auricular flutter
definition source: WEB: http://medical-dictionary.thefreedictionary.com/atrial+flutter
has_MedDRA_id: 10003662
see also: CTCAE: E10087
see also: HPO: HP_0004749
see also: NCIt: C51224
see also: SIDER: C0004239

balance disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of a disturbance that causes an individual to feel unsteady, giddy, woozy, or have a sensation of movement, spinning, or floating.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Balance_disorder
has_MedDRA_id: 10049848
see also: HPO: HP_0002141
see also: SIDER: C0575090

blister AE
type: Class
subclass of: skin AE
definition: blister AE is a skin adverse event that results in a small pocket of fluid within the upper layers of the skin
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Blister
has_MedDRA_id: 10005191
see also: HPO: HP_0008066
see also: SIDER: C0005758

cellulitis AE
type: Class
subclass of: inflammation AE
definition: cellulitis AE is an inflammation AE that is a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Cellulitis
has_MedDRA_id: 10007882
see also: HPO: HP_0003553
see also: SIDER: C0007642

cold sweat AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of a type of perspiration usually associated with anxiety or fear
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Cold_sweat

convulsion AE
type: Class
subclass of: muscle AE
definition: convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Convulsion
has_MedDRA_id: 10010904
see also: HPO: HP_0001250
see also: SIDER: C0009951

difficulty in walking AE
type: Class
subclass of: movement disorder AE
definition editor: SS, YH
comment: a movement disorder AE that has an outcome of difficulty in walking properly

dysgeusia AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a behavior and neurological AE that has an outcome of distortion of the sense of taste
definition editor: SS, YH, MW
definition source: WEB: http://en.wikipedia.org/wiki/Dysgeusia
has_MedDRA_id: 10013911
see also: HPO: HP_0000223
see also: SIDER: C0013378

dyskinesia AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of dyskinesia
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Dyskinesia
has_MedDRA_id: 10013916
comment: dyskinesia is a movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements
see also: HPO: HP_0100660
see also: SIDER: C0013384

dyspnea AE
type: Class
subclass of: abnormal respiration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: An abnormal respiration AE that is characterized by a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity.
editor note: MedDRA: 10013968 is for "dyspnoea"; MedDRA: 10013963 is for "dyspnea".
definition editor: SS, YH
alternative term: air hunger
alternative term: dyspnoea
alternative term: shortness of breath
definition source: WEB: http://en.wikipedia.org/wiki/Dyspnoea
definition source: https://en.wikipedia.org/wiki/Shortness_of_breath
definition source: https://www.mayoclinic.org/symptoms/shortness-of-breath/basics/definition/sym-20050890
Chinese translation: 呼吸困难
has_MedDRA_id: 10013963
has_MedDRA_id: 10013968
see also: CTCAE: E13368
see also: HPO: HP_0002094
see also: NCIt: C2998
see also: SIDER: C0013404
see also: UMLS CUI: C0013404

electromyogram result abnormal AE
type: Class
subclass of: behavioral and neurological test abnormal AE
definition editor: SS, YH, EB
definition source: WEB: http://en.wikipedia.org/wiki/Electromyography
has_MedDRA_id: 10014431
comment: a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of abnormal activity in skeletal muscles evaluted and measured by electromyography

eye irritation AE
type: Class
subclass of: eye AE
definition: eye irritation AE is an eye disorder AE that results in mild eye redness, itching, or tearing
definition editor: SS, YH
definition source: WEB: http://www.freemd.com/eye-irritation/
has_MedDRA_id: 10015946
see also: HPO: HP_0000478
see also: SIDER: C0235266

eye pruritus AE
type: Class
subclass of: pruritus AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000970
definition: eye pruritus AE is a pruritus AE (an unpleasant sensation that evokes the desire or reflex to scratch) at the eye area
definition editor: SS, YH
has_MedDRA_id: 10052140
see also: HPO: HP_0000989
see also: SIDER: C0022281

glomerulonephritis AE
type: Class
subclass of: kidney AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000074
definition: glomerulonephritis AE is a kidney disorder AE that results in a renal disease that is characterized by inflammation of the glomeruli, or small blood vessels in the kidneys.
definition editor: SS, YH
alternative term: glomerular nephritis AE
definition source: WEB: http://en.wikipedia.org/wiki/Glomerulonephritis
see also: HPO: HP_0000099
see also: SIDER: C0017658

bundle branch block right AE
type: Class
subclass of: conduction system disorder AE
definition: A conduction system disorder AE that is a condition in which the electrical impulse from the bundle of His to the ventricles is delayed or fails to conduct along the right bundle branch, resulting in right ventricular depolarization by cell-to-cell conduction spreading from the interventricular septum and left ventricle to the right ventricle–ie, slow and uncoordinated Natural history Surgically induced RBBB has few acute hemodynamic consequences and a generally benign course long term; rarely, progression to complete heart block and sudden death occur, especially if accompanied by major His-Purkinje system–eg, left anterior hemiblock, first-degree AV block–injury; tetralogy of Fallot repair with an RBBB and a markedly prolonged QRS duration >180 ms have an ↑ risk for ventricular arrhythmias and sudden death.
definition editor: SS
alternative term: RBBB
alternative term: right bundle branch block
definition source: WEB: http://medical-dictionary.thefreedictionary.com/right+bundle+branch+block
has_MedDRA_id: 10006582
see also: HPO: HP_0011712
see also: SIDER: C0085615

conduction system disorder AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiac disorder AE of the electrical conduction system that controls the heart rate, generates and conducts electrical impulses throughout the muscle of the heart, stimulating the heart to contract and pump blood.
definition editor: SS
alternative term: cardiac conduction disorder AE
alternative term: conduction disorder AE
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=8407
has_MedDRA_id: 10000032
has_MedDRA_id: 10010276
see also: CTCAE: E10114
see also: NCIt: C78245

hypoesthesia AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of hypoaesthesia, meaning that skin loses some of its sensitivity to pain or touch
definition editor: SS, YH
alternative term: disesthesia AE
alternative term: hypoaesthesia AE
definition source: WEB:http://medguides.medicines.org.uk/document.aspx?name=hypoaesthesia
has_MedDRA_id: 10020937
see also: HPO: HP_0010830
see also: SIDER: C0020580

arterial thrombosis AE
type: Class
subclass of: thrombosis AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: a thrombosis AE that has an outcome of a blood clot within an artery
editor note: [SS] Per DRA and KKB's comment, arterial thrombosis may also be characterized as an embolism.
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23236330
has_MedDRA_id: 10003178
see also: HPO: HP_0004420
see also: SIDER: C0151942

influenza AE
type: Class
subclass of: viral infection AE
definition: a viral infection AE that demonstrates an influenza viral infection. Influenza is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Influenza
see also: HPO: HP_0005376
see also: MDR: 10022000
see also: SIDER: C0021400

arteriosclerosis coronary artery AE
type: Class
subclass of: coronary artery disorder AE
definition: a coronary artery disease AE with the outcome hardening of the coronary artery due to a build up of waxy plaque on the inside of blood vessels
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Coronary+Arteriosclerosis
has_MedDRA_id: 10003211
see also: HPO: HP_0004929
see also: SIDER: C0010054

injected limb mobility decreased AE
type: Class
subclass of: mobility decreased AE
definition: injected limb mobility decreased AE is a mobility decreased AE that occurs in the limb in which injection is administered
definition editor: SS, YH

injection-site hematoma AE
type: Class
subclass of: injection-site AE
subclass of: hematoma AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: a haematoma AE that has an outcome of injection-site haematoma, which results in a collection of blood outside the blood vessels at the physical area of injection
definition editor: SS, YH
alternative term: injection-site haematoma AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hematoma
definition source: http://en.wikipedia.org/wiki/Hematoma
has_MedDRA_id: 10022066

injection-site induration AE
type: Class
subclass of: injection-site AE
subclass of: skin AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site
definition editor: SS, YH
definition source: WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration

injection-site pruritus AE
type: Class
subclass of: injection-site AE
subclass of: pruritus AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Itch
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pruritus
has_MedDRA_id: 10022093

injection-site rash AE
type: Class
subclass of: rash AE
subclass of: injection-site AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Rash

injection-site warmth AE
type: Class
subclass of: injection-site AE
subclass of: homeostasis AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site
definition editor: SS, YH

joint swelling AE
type: Class
subclass of: joint disorder AE
definition: A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint
definition editor: SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm
has_MedDRA_id: 10023232
see also: HPO: HP_0005833
see also: SIDER: C0152031

kidney AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002113
subclass of: urinary system AE
definition: an adverse event that occurs in kidney.
definition editor: SS, YH, DA
alternative term: abnormal renal function AE
alternative term: renal disorder AE
definition source: https://medlineplus.gov/ency/article/001265.htm
has_MedDRA_id: 10038428

lacrimation increased AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of an increase in production, secretion, and shedding of tears
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Tears
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=6199
has_MedDRA_id: 10023644
see also: HPO: HP_0009926
see also: SIDER: C0152227

lip swelling AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001833
definition: lip swelling AE is an edema (swelling) AE that results in enlargement or protuberance in the lip
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Swelling_%28medical%29
has_MedDRA_id: 10024570
see also: HPO: HP_0000159
see also: SIDER: C0240211

lymphadenitis AE
type: Class
subclass of: lymphadenopathy AE
definition: A lymphadenopathy AE that results in swollen/enlarged lymph nodes
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Lymphadenopathy
see also: HPO: HP_0002840
see also: SIDER: C0024205

mobility decreased AE
type: Class
subclass of: nervous system AE
definition: mobility decreased AE is a nervous system AE that results in difficulty in movement leading to less ability to move part(s) of body
definition editor: SS, YH
has_MedDRA_id: 10048334
see also: HPO: HP_0006217
see also: SIDER: C0700572

muscular weakness AE
type: Class
subclass of: muscle AE
definition: a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength).
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Muscular_weakness
has_MedDRA_id: 10028372
see also: HPO: HP_0001324
see also: SIDER: C0151786

musculoskeletal stiffness AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton
definition editor: SS, YH
has_MedDRA_id: 10052904
see also: HPO: HP_0003552
see also: SIDER: C0948525

nasal congestion AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Nasal_congestion
has_MedDRA_id: 10028735
see also: CTCAE: E13450
see also: HPO: HP_0001742
see also: NCIt: C78500
see also: SIDER: C0027424

nasopharyngitis AE
type: Class
subclass of: respiratory system inflammation AE
definition: a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system
definition editor: SS, YH
alternative term: common cold AE
definition source: WEB: http://en.wikipedia.org/wiki/Nasopharyngitis
see also: HPO: HP_0002087
see also: SIDER: C0027441

peripheral neuropathy AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0000010
subclass of: neuropathy AE
definition: an neuropathy AE that results in a damage to the peripheral nervous system (PNS, outside the brain and spinal cord), the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body.
definition editor: SS, YH
alternative term: neuropathy peripheral AE
definition source: WEB: http://en.wikipedia.org/wiki/Peripheral_neuropathy
definition source: WEB: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm
has_MedDRA_id: 10029331

ocular hyperemia AE
type: Class
subclass of: eye AE
definition: ocular hyperaemia AE is an eye disorder AE that results in severe redness and irritation of the eyes
definition editor: SS, YH
alternative term: ocular hyperaemia AE
definition source: WEB: http://www.med.miami.edu/news/view.asp?id=259
has_MedDRA_id: 10030041

oropharyngeal pain AE
type: Class
subclass of: pain AE
definition: a pain AE that has an outcome of oropharyngeal pain
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Oropharyngeal_airway
has_MedDRA_id: 10068319
comment: oropharyngeal pain is a pain in oral airway
see also: HPO: HP_0010833
see also: SIDER: C2363731

otitis media AE
type: Class
subclass of: ear AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Otitis_media
has_MedDRA_id: 10033078
see also: CTCAE: E11477
see also: HPO: HP_0008623
see also: NCIt: C34885
see also: SIDER: C0029882

pericarditis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has an outcome of pericaditis, which is a cardiovascular disorder that results in a condition in which the sac-like covering around the heart (pericardium) becomes inflamed
definition editor: SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000182.htm
has_MedDRA_id: 10034484
see also: CTCAE: E10180
see also: HPO: HP_0001701
see also: NCIt: C34915
see also: SIDER: C0031046

pharyngeal edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0006562
definition: pharyngeal edema AE is an edema AE that results in an bbnormal fluid accumulation in TISSUES or body cavities in pharynx (throat swelling).
definition editor: SS, YH
alternative term: pharyngeal oedema AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/mesh/68004487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Mesh.Mesh_ResultsPanel.Mesh_RVDocSum

pharyngitis AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Pharyngitis
has_MedDRA_id: 10034835
see also: CTCAE: E11525
see also: HPO: HP_0100776
see also: NCIt: C26851
see also: SIDER: C0031350

pharyngolaryngeal pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that shows a pain in sinus and throat
definition editor: SS, YH, MW
definition source: WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/
has_MedDRA_id: 10034844
see also: CTCAE: E13482
see also: HPO: HP_0010833
see also: NCIt: C78556
see also: SIDER: C0858635

macular rash AE
type: Class
subclass of: rash AE
definition: rash macular AE is a rash AE that results in a skin eruption in which the lesions are flat and less than 1 cm in diameter
definition editor: SS, YH
alternative term: rash macular AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/macular+rash
see also: HPO: HP_0000988
see also: SIDER: C0221201

papular rash AE
type: Class
subclass of: rash AE
definition: a rash AE that shows clustered papules, i.e., small, round, raised bumps that have clear borders.
definition editor: SS, YH
alternative term: rash papular AE
definition source: WEB: http://en.wikipedia.org/wiki/Rash
definition source: WEB: http://www.healthline.com/symptom/papule
definition source: WEB: http://www.rightdiagnosis.com/sym/papular_rash.htm
has_MedDRA_id: 10037876
see also: HPO: HP_0007432
see also: SIDER: C0221202

respiratory distress AE
type: Class
subclass of: respiratory system AE
definition: A respiratory system AE thta is characterized by inflammation of the lung parenchyma leading to impaired gas exchange with concomitant systemic release of inflammatory mediators causing inflammation, hypoxemia and frequently resulting in multiple organ failure.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Acute_respiratory_distress_syndrome
has_MedDRA_id: 10038687
see also: HPO: HP_0002747
see also: SIDER: C0476273

respiratory tract congestion AE
type: Class
subclass of: respiratory system AE
definition: respiratory tract congestion AE is a respiratory system AE that results in congestion in respiratory tract
definition editor: SS, YH

retching AE
type: Class
subclass of: digestive system AE
definition: retching AE is a digestive system AE that results in a process in the human body where gastric (and sometimes duodenal) contents are forced into the esophagus, but do not enter the pharynx
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Retching
has_MedDRA_id: 10038776

rhinitis AE
type: Class
subclass of: respiratory system inflammation AE
definition: rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose
definition editor: SS, YH
alternative term: runny nose
definition source: WEB: http://en.wikipedia.org/wiki/Rhinitis
definition source: WEB: http://medical-dictionary.thefreedictionary.com/rhinitis
has_MedDRA_id: 10028116
see also: HPO: HP_0002257
see also: SIDER: C0035455

rhinorrhea AE
type: Class
subclass of: respiratory system AE
definition: rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid
definition editor: SS, YH
alternative term: rhinorrhoea AE
definition source: WEB: http://en.wikipedia.org/wiki/Rhinorrhoea

shoulder pain AE
type: Class
subclass of: pain AE
definition: a pain AE that occurs in shoulder
definition: shoulder pain is a pain iin or around the shoulder joint
definition editor: SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003171.htm

sinus congestion AE
type: Class
subclass of: nasal congestion AE
definition: sinus congestion AE is a nasal congestion AE that results in blockage of the air cavities in the cranial bones or nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Sinus_%28anatomy%29, http://en.wikipedia.org/wiki/Nasal_congestion
see also: HPO: HP_0002257
see also: SIDER: C0152029

sneezing AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: sneezing AE is a respiratory system adverse event that results in sternutation, a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa
definition editor: SS, YH, MW
alternative term: sternutation
definition source: WEB: http://en.wikipedia.org/wiki/Sneezing
has_MedDRA_id: 10041232

tachycardia AE
type: Class
subclass of: increased heart rate AE
definition: an increased heart rate AE where the heart rate exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual)
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Tachycardia
has_MedDRA_id: 10043071
see also: HPO: HP_0001649
see also: SIDER: C0039231

tendonitis AE
type: Class
subclass of: tendon disorder AE
definition: a tendon disorder AE that has an outcome of tendonitis
definition editor: SS, YH
alternative term: tendinitis AE
definition source: WEB: http://en.wikipedia.org/wiki/Tendinitis
comment: tendonitis is a tendon disorder that results in an inflammation of a tendon
see also: HPO: HP_0100261
see also: SIDER: C0039503

throat tightness AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000341
definition: a sensory capability AE that has an outcome of a sensation of tightness in the throat
has_MedDRA_id: 10043528

upper respiratory tract infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001557
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx
definition editor: SS, YH
alternative term: URI, URTI
definition source: WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection
has_MedDRA_id: 10046300
see also: CTCAE: E11604
see also: HPO: HP_0002788
see also: NCIt: C35650
see also: SIDER: C0041912

varicella AE
type: Class
subclass of: OAE_0003233
definition: a viral infection AE that results in an acute contagious diseased caused by herpes varicella zoster virus; causes a rash of vesicles on the face and body.
definition editor: SS, YH
alternative term: chicken pox AE
alternative term: varicella zoster virus infection AE
definition source: WEB: http://wordnetweb.princeton.edu/perl/webwn?s=varicella
see also: HPO: HP_0005428
see also: SIDER: C0008049

paresthesia oral AE
type: Class
subclass of: paresthesia AE
definition: a paresthesia AE that occurs in oral area.
definition editor: SS, YH
alternative term: paraesthesia oral AE
definition source: http://www.answers.com/topic/oral-paresthesia
has_MedDRA_id: 10057372
comment: paraesthesia oral is a paresthesia that results in a numbness or tingling that occurs in the mucosa or tissues of the oral cavity.
see also: HPO: HP_0003401
see also: SIDER: C0521591

fever AE
type: Class
subclass of: abnormal body temperature AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal body temperature AE which has an outcome of fever
definition editor: YH, SS, MW
alternative term: body temperature increased AE
alternative term: febrile response
alternative term: pyrexia AE
definition source: Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828.
definition source: WEB: http://en.wikipedia.org/wiki/Pyrexia
has_MedDRA_id: 10005911
has_MedDRA_id: 10016558
has_MedDRA_id: 10037660
comment: Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °F).
see also: CTCAE: E11102
see also: NCIt: C3038

rash AE
type: Class
subclass of: skin AE
definition: a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful.
definition editor: YH
definition source: URL: http://en.wikipedia.org/wiki/Rash
definition source: URL: http://www.webmd.com/skin-problems-and-treatments/guide/common-rashes
definition source: Wick JY. Drug-induced rash: nuisance or threat? Consult Pharm. 2013 Mar;28(3):160-6. PMID: 23462025.
has_MedDRA_id: 10037844
comment: Drug-induced rash is the most commonly reported drug reaction.
see also: HPO: HP_0000988
see also: SIDER: C0015230

infection AE
type: Class
subclass of: adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite.
editor note: change of name from 'infection adverse event' to 'infectious adverse event' on 09/23/13 for a better clinical relevance, move 'infection adverse event' as an alternative term - SS
definition editor: YH, JX
alternative term: infectious adverse event
definition source: WEB: http://medical-dictionary.thefreedictionary.com/infection
adverse event outcome: infection
has_MedDRA_id: 10021789

syndrome AE
type: Class
subclass of: adverse event
definition: An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others.
definition editor: YH

agitation AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has an outcome of emotional state of excitement or restlessness
definition editor: YH, MW
has_MedDRA_id: 10001497
see also: HPO: HP_0000711
see also: SIDER: C0085631

injection-site AE
type: Class
equivalent class: Restriction
  on property: occurs in
  some values from: VO_0000300
equivalent class: Restriction
  on property: AE occurs in
  some values from: VO_0000300
subclass of: medical intervention site AE
subclass of: local AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: injection-site AE is an AE that occurs in an injection site (e.g., during vaccination).
definition editor: YH, JX, SS
alternative term: injection site AE
alternative term: injection-site adverse event
alternative term: injection-site reaction
alternative term: local reaction AE
has_MedDRA_id: 10022095
see also: CTCAE: E11138
see also: NCIt: C3508

injection-site hypersensitivity AE
type: Class
subclass of: injection-site AE
subclass of: hypersensitivity AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: a hypersensitivity AE which has an outcome of injection-site hypersensitivity
definition editor: YH

injection-site edema AE
type: Class
subclass of: injection-site AE
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found.
definition editor: YH, RR
alternative term: injection-site oedema AE
alternative term: injection-site swelling AE
definition source: WEB: http://www.uptodate.com/contents/edema-swelling-beyond-the-basics
has_MedDRA_id: 10053425

injection-site pain AE
type: Class
subclass of: injection-site AE
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: a pain AE that occurs in an injection site of a medical intervention
definition editor: YH
has_MedDRA_id: 10022086

injection-site inflammation AE
type: Class
subclass of: injection-site AE
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: an inflammation AE which has an outcome of injection-site inflammation
definition editor: YH

injection-site hemorrhage AE
type: Class
subclass of: injection-site AE
subclass of: hemorrhage AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: a hemorrhage AE that has an outcome of injection-site hemorrhage
definition editor: YH
has_MedDRA_id: 10022067

injection-site mass AE
type: Class
subclass of: tumor AE
subclass of: injection-site AE
subclass of: Restriction
  on property: AE occurs in
  some values from: VO_0000300
definition: a tumor or mass AE that occurs in an injection-site
definition editor: YH, SS
alternative term: injection site nodule AE
comment: injection-site mass is a mass at physical injection site

pruritus AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin adverse event that has an outcome of pruritus
definition editor: YH, SS, MW
alternative term: itch
alternative term: itching
alternative term: pruritus generalised AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity
has_MedDRA_id: 10037087
comment: Pruritus is an itch (Latin: pruritus), i.e., an unpleasant sensation that evokes the desire or reflex to scratch.
see also: HPO: HP_0000989
see also: SIDER: C0033774

pain AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sensory capability AE that has an outcome of pain in a patient
definition editor: YH, MW
has_MedDRA_id: 10033371
see also: CTCAE: E11167
see also: HPO: HP_0010833
see also: NCIt: C3303
see also: SIDER: C0030193

myalgia AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders.
definition editor: YH, MW
alternative term: muscle pain AE
has_MedDRA_id: 10028411
see also: HPO: HP_0003326
see also: SIDER: C0231528

urticaria AE
type: Class
subclass of: rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Urticaria AE is a rash AE notable for dark red, raised, itchy bumps.
definition editor: YH, MW
alternative term: hives
has_MedDRA_id: 10046735
see also: HPO: HP_0001025
see also: SIDER: C0042109

headache AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of headache
definition editor: YH, MW
has_MedDRA_id: 10019211
see also: CTCAE: E12678
see also: HPO: HP_0002315
see also: NCIt: C34661
see also: SIDER: C0018681

respiratory system AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: occurs in
    some values from: UBERON_0001004
subclass of: adverse event
definition: an AE that occurs in respiratory system.
editor note: I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He
definition editor: YH

leukocyte cell number increased AE
type: Class
subclass of: leukocyte cell number abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a leukocyte cell number abnormal AE that has an outcome of greater than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543).
definition editor: SS, YH, EB
alternative term: increased leukocyte cell number AE
alternative term: leukocytosis AE
alternative term: white blood cell count increased AE
definition source: WEB: http://en.wikipedia.org/wiki/Leukocytosis
has_MedDRA_id: 10024378
has_MedDRA_id: 10047943
see also: CTCAE: E10048
see also: MP: MP_0000218
see also: NCIt: C35524

leukocyte cell number decreased AE
type: Class
subclass of: leukocyte cell number abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a leukocyte cell number abnormal AE that has an outcome of reduction in the number of leukocytes, or of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
alternative term: decreased leukocyte cell number AE
alternative term: white blood cell count decreased AE
has_MedDRA_id: 10047942
see also: CTCAE: E12232
see also: MP: MP_0000221
see also: NCIt: C26816

abnormal blood pressure AE
type: Class
subclass of: cardiovascular AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries
see also: MP: MP_0000230

asthenia AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength.
definition editor: YH
has_MedDRA_id: 10003549
see also: HPO: HP_0001324
see also: SIDER: C0004093

muscle ache AE
type: Class
subclass of: myalgia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002385
definition: a muscle pain AE that has an outcome of muscle ache.
definition editor: YH

maculo-papular rash AE
type: Class
subclass of: rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: A rash AE that shows a flat, red area on the skin overed with small confluent bumps.
definition editor: YH, MW
alternative term: maculopapular rash AE
alternative term: rash maculo-papular AE
alternative term: rash maculopapular AE
definition source: WEB: http://en.wikipedia.org/wiki/Maculopapular_rash
has_MedDRA_id: 10037868
comment: The term "maculopapular" is a compound: macules are small, flat discolored spots on the surface of the skin; and papules are small, raised bumps.

arthralgia AE
type: Class
subclass of: joint disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory.
definition editor: YH, MW
has_MedDRA_id: 10003239
see also: HPO: HP_0002829
see also: SIDER: C0003862

vesiculobullous rash AE
type: Class
subclass of: rash AE
definition: vesiculobullous rash AE is a rash AE characterized by serous-fluid-filled vesicles (blisters)
definition editor: YH
see also: HPO: HP_0000988
see also: SIDER: C0151883

screaming syndrome AE
type: Class
subclass of: syndrome AE
definition: a syndrome AE which has an outcome of screaming syndrome
definition editor: YH

dizziness AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sensory capability AE that has an outcome of dizziness
definition editor: YH, SS, MW
has_MedDRA_id: 10013573
comment: Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs.
see also: HPO: HP_0002321
see also: SIDER: C0012833

edema limbs AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: peripheral edema AE is an edema AE that results in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids
definition editor: YH, SS
alternative term: edema peripheral AE
alternative term: oedema peripheral AE
alternative term: peripheral edema AE
definition source: WEB: http://en.wikipedia.org/wiki/Peripheral_edema
has_MedDRA_id: 10030124
has_MedDRA_id: 10050068
see also: CTCAE: E11086
see also: NCIt: C78262

malaise AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a sensory capability AE that has an outcome of malaise
definition editor: YH
has_MedDRA_id: 10025482
comment: Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise.
see also: CTCAE: E11152
see also: HPO: HP_0002321
see also: NCIt: C3832
see also: SIDER: C0231218

somnolence AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a behavior and neurological AE that has an outcome of somnolence
definition editor: YH, SS, MW
alternative term: drowsiness
has_MedDRA_id: 10041349
comment: Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia).
see also: HPO: HP_0001262
see also: SIDER: C2830004

paresthesia AE
type: Class
subclass of: sensory neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sensory neuropathy AE that shows a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect.
definition editor: YH, MW
alternative term: paraesthesia AE
definition source: WEB: http://en.wikipedia.org/wiki/Paraesthesia
has_MedDRA_id: 10033775
has_MedDRA_id: 10033987
comment: Paresthesia is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic.
see also: CTCAE: E12758
see also: NCIt: C28177

crying abnormal AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of abnormal crying in a patient
definition editor: YH
has_MedDRA_id: 10011469

chills AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sensory capability AE that has an outcome of chills
definition editor: YH
alternative term: feeling cold AE
has_MedDRA_id: 10008531
comment: Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold.
see also: CTCAE: E11074
see also: HPO: HP_0001945
see also: NCIt: C35143
see also: SIDER: C0085593

stupor AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of stupor
definition editor: YH
has_MedDRA_id: 10042264
comment: Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization.
see also: HPO: HP_0004372
see also: SIDER: C0085628

anorexia AE
type: Class
subclass of: gustatory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a gustatory system AE which demonstrates a decreased sensation of appetite.
definition editor: YH, MW
alternative term: anorexia nervosa AE
alternative term: decreased appetite AE
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/anorexia/basics/definition/con-20033002
Chinese translation: 厌食症
has_MedDRA_id: 10002646
has_MedDRA_id: 10002649
has_MedDRA_id: 10061428
see also: CTCAE: E12252
see also: HPO: HP_0002039
see also: NCIt: C2875
see also: SIDER: C0003123

face edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001456
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: face edema AE is an edema AE that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms
definition editor: YH, SS, MW
alternative term: emema face AE
alternative term: face oedema AE
alternative term: oedema face AE
definition source: WEB:http://www.nlm.nih.gov/medlineplus/ency/article/003105.htm
definition source: swelling face
has_MedDRA_id: 10014222
has_MedDRA_id: 10016029
has_MedDRA_id: 10042682
see also: CTCAE: E11082
see also: NCIt: C78289

cough AE
type: Class
subclass of: abnormal respiration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear
definition editor: YH, SS, MW
alternative term: coughing AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cough
definition source: WEB: http://www.nlm.nih.gov/medlineplus/cough.html
adverse event outcome: cough
has_MedDRA_id: 10011224

flu syndrome AE
type: Class
subclass of: acute brain syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention.
definition editor: YH
alternative term: flu-like symptom AE
see also: CTCAE: E11108
see also: NCIt: C78302

syncope AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a sensory capability AE that has an outcome of loss of consciousness, fainting
definition editor: YH, SS, MW
alternative term: Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness.
alternative term: fainting
definition source: WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29
definition source: WEB: http://en.wikipedia.org/wiki/Unconsciousness
has_MedDRA_id: 10024855
has_MedDRA_id: 10042772
see also: CTCAE: E12832
see also: HPO: HP_0001279
see also: NCIt: C35053
see also: SIDER: C0039070

sweating AE
type: Class
subclass of: skin AE
definition: a skin adverse event that has an outcome of sweating
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
see also: HPO: HP_0000975
see also: SIDER: C0038990

abdominal pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, SS
definition source: WEB: http://en.wikipedia.org/wiki/Abdominal_pain
has_MedDRA_id: 10000081
comment: a pain AE that is observed in abdominal cavity
see also: HPO: HP_0002027
see also: SIDER: C0000737

hypertension AE
type: Class
subclass of: abnormal blood pressure AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states
definition editor: YH, SS, MW
alternative term: blood pressure increased
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21722707
has_MedDRA_id: 10005750
has_MedDRA_id: 10020772
see also: CTCAE: E13785
see also: HPO: HP_0000822
see also: MP: MP_0000231
see also: NCIt: C3117
see also: SIDER: C0020538

aortic valve stenosis AE
type: Class
subclass of: cardiac valve disease AE
definition: a cardiac valve disease AE that is characterized by a condition of the heart in which the aortic valve, located between the aorta and left ventricle of the heart, is norrower than normal size
definition editor: SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/aortic+valve+stenosis
has_MedDRA_id: 10002918
see also: HPO: HP_0005173
see also: SIDER: C0003507

myasthenia AE
type: Class
subclass of: muscular weakness AE
definition: a muscular weakness AE that has an outcome of myasthenia. Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability.
definition editor: YH, SS
alternative term: myasthenia gravis
alternative term: myasthenia syndrome AE
alternative term: myasthenic syndrome AE
see also: HPO: HP_0001324
see also: SIDER: C0947912

chest pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0001443
definition: a pain AE that occurs at the chest
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10008479
see also: HPO: HP_0001681
see also: SIDER: C0008031

sensory axonal AE
type: Class
subclass of: sensory neuropathy AE
definition: a sensory neuropathy AE which has an outcome of sensory axonal characterized by damage to axonas of the peripheral nervous system (PNS)
definition editor: AG, YH

central serous retinopathy AE
type: Class
subclass of: abnormal vision AE
definition: an abnormal vision AE characterised by leakage of fluid under the retina causing visual impairment, usually in one eye.
definition editor: SJ, YH
alternative term: central serous chorioretinopathy
definition source: WEB: http://en.wikipedia.org/wiki/Central_serous_retinopathy
has_MedDRA_id: 10063118

twitching AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of twitching, an involuntary sudden movement of part of the body.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH

febrile seizure AE
type: Class
subclass of: seizure AE
definition: a seizure AE that has an outcome of a seizure disorder associated with an elevated temperature
definition editor: YH, BY
definition source: http://emedicine.medscape.com/article/1176205-overview

asthma AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE which has an outcome of asthma
definition editor: YH
Chinese translation: 哮喘
has_MedDRA_id: 10003553
comment: Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation.
see also: HPO: HP_0002099
see also: SIDER: C0004096

neck pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000974
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of neck pain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, MW
has_MedDRA_id: 10028836
see also: CTCAE: E12493
see also: HPO: HP_0003418
see also: NCIt: C50663
see also: SIDER: C0007859

arthritis infective AE
type: Class
subclass of: arthritis AE
definition: an arthritis AE that has an outcome of inflammation of a joint, resulting from infectious agents, such as bacteria and viruses
definition editor: DJ, SS, YH
definition source: WEB: http://www.rightdiagnosis.com/i/infectious_arthritis/intro.htm
has_MedDRA_id: 10060968
see also: HPO: HP_0003095
see also: SIDER: C0003869

back pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of back pain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, MW
has_MedDRA_id: 10003988
see also: HPO: HP_0003418
see also: SIDER: C0004604

alopecia AE
type: Class
subclass of: hair AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a hair AE that has an outcome of alopecia and occurs after a medical intervention.
definition source: VAE, MW
has_MedDRA_id: 10001760
comment: alopecia means the absence of hair or loss of hair. It is not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition.
see also: HPO: HP_0001596
see also: MP: MP_0000414
see also: SIDER: C0002170

gastrointestinal hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001007
definition: a hemorrhage AE that has an outcome of gastrointestinal hemorrhage
alternative term: gastrointestinal haemorrhage AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/gastrointestinal+hemorrhage
has_MedDRA_id: 10017955
comment: bleeding in the stomach and/or the intestines
see also: MP: MP_0000465

eyes gaze upward AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of eyes gaze upward
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH

neuropathy AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that shows a damage to or disease affecting the nerves.
editor note: Neuropathy is often classified according to the types or location of nerves that are affected. Neuropathy can also be classified according to the disease causing it. (For example, neuropathy from the effects of diabetes is called diabetic neuropathy. Ref: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy.
definition editor: YH, RR
definition source: WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm
definition source: WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
definition source: WEB: http://www.medicalnewstoday.com/articles/147963.php
definition source: WEB: http://www.neuropathy.org/
Chinese translation: 神经病变
see also: HPO: HP_0007141
see also: SIDER: C0442874

skin nodule AE
type: Class
subclass of: skin AE
definition: a skin adverse event that has an outcome of skin nodule
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
see also: HPO: HP_0200036
see also: SIDER: C0037287

arthrosis AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of arthrosis.
definition editor: YH
comment: Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage.

hypokinesia AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event which has an outcome of hypokinesia, refering to slow or diminished movement of body musculature.
definition editor: YH
has_MedDRA_id: 10021021
see also: HPO: HP_0002375
see also: SIDER: C0086439

muscle twitch AE
type: Class
subclass of: twitching AE
definition: Muscle twitch AE is a twitching AE that is a small, local, involuntary muscle contraction and relaxation which may be visible under the skin.
definition editor: JX, YH
alternative term: WEB: http://en.wikipedia.org/wiki/Fasciculation
alternative term: fasciculation AE
alternative term: muscle contraction AE
alternative term: myokymia AE
has_MedDRA_id: 10028346

skin discoloration AE
type: Class
subclass of: skin AE
definition: skin discoloration AE is a skin adverse event that results in change in color of skin or mucus membranes
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, SS
alternative term: skin discolouration AE
has_MedDRA_id: 10040829

shingles AE
type: Class
subclass of: varicella AE
definition: a varicella zoster virus infection AE that occurs in adults and rarely in children.
definition editor: YH
alternative term: herpes zoster AE
alternative term: zoster AE
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/shingles/basics/causes/con-20019574
has_MedDRA_id: 10019974
comment: Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles (an illness with very different symptoms) often many years after the initial infection.
see also: HPO: HP_0005353
see also: SIDER: C0019360

laryngismus AE
type: Class
subclass of: movement disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001737
definition: a movement disorder AE that has an outcome of laryngismus
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: laryngospasm
alternative term: sudden laryngeal spasm with crowing inhalation and cyanosis
comment: Laryngismus is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords.

speech disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of disorder in speech
definition editor: YH
has_MedDRA_id: 10041466
see also: HPO: HP_0006977
see also: SIDER: C0037822

hemorrhage AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that has an outcome of hemorrhage
alternative term: bleeding AE
alternative term: haemorrhage AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage
has_MedDRA_id: 10055798
comment: loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels
see also: MP: MP_0001914

neck rigidity AE
type: Class
subclass of: bone AE
definition: a bone disorder AE which has an outcome of neck rigidity
definition editor: YH

Guillain-Barre syndrome AE
type: Class
subclass of: neuropathy AE
definition: a nervous system AE that has the symptom of GBS. Guillain-Barre syndrome (GBS) is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barre occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm.
definition editor: YH, SS
alternative term: GBS AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299621
has_MedDRA_id: 10018767
see also: HPO: HP_0007131
see also: SIDER: C0018378

nausea and vomiting AE
type: Class
subclass of: abnormal digestion AE
definition: an abnormal digestion AE which has an outcome of nausea and vomiting
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543).
editor note: This term will most likely removed since it is just a combination of nausea and vomiting.
definition editor: YH

sudden infant death AE
type: Class
subclass of: sudden death AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0034920
definition: a sudden death AE that occurs to an infant.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH

fever with chills AE
type: Class
subclass of: fever AE
definition: a fever AE that has an outcome of fever with chills, which is successive stages of chills and fever. This is a symptom of malaria.
definition editor: YH
alternative term: chills and fever AE
has_MedDRA_id: 10016559

personality disorder AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that is characterized by enduring maladaptive patterns of behavior, cognition, and inner experience, exhibited across many contexts and deviating markedly from those accepted by the individual's culture.
definition editor: YH, MW
definition source: WEB: https://en.wikipedia.org/wiki/Personality_disorder
has_MedDRA_id: 10034721
see also: HPO: HP_0000751
see also: SIDER: C0031212

lung AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002048
subclass of: respiratory system AE
definition: a respiratory system AE which has an outcome of lung disorder
definition editor: YH
alternative term: lung disorder AE
has_MedDRA_id: 10025082
see also: HPO: HP_0006552
see also: SIDER: C0024115

muscle AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002385
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal system AE that occurs in muscle.
definition editor: YH

hepatobiliary or pancreatic AE
type: Class
subclass of: adverse event
definition: an adverse event that occurs in liver, biliary, and pancreatic areas.
definition editor: YH, JX
alternative term: liver, biliary, and pancreatic disorder AE
definition source: URL: http://www.ijhpd.com/
definition source: WEB: http://www.uchospitals.edu/online-library/content=P00670

enlarged liver AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE which has an outcome of an enlarged liver, or larger than average size of the liver
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly' was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
see also: MP: MP_0000599

meningitis AE
type: Class
subclass of: meninges inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a brain inflammation AE which results in an inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases.
definition editor: YH, JX
definition source: WEB: http://www.cdc.gov/meningitis/index.html
Chinese translation: 脑膜炎
has_MedDRA_id: 10027199
see also: CTCAE: E11458
see also: HPO: HP_0001287
see also: NCIt: C26828
see also: SIDER: C0025289

digestive system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0001007
subclass of: adverse event
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001007
definition: an AE that occurs in digestive system.
definition editor: YH

facial paralysis AE
type: Class
subclass of: paralysis AE
definition: a paralysis AE that has an outcome of paralysis in face
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
see also: HPO: HP_0007209
see also: SIDER: C0015469

confusion AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has an outcome of confusion, which is a mild form of delirium.
definition editor: YH, KM
alternative term: confused state AE
alternative term: mental confusion AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/mental+confusion
has_MedDRA_id: 10010300
has_MedDRA_id: 10010305
see also: CTCAE: E12889
see also: NCIt: C37928

joint disorder AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0000982
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal system AE which has an outcome of joint disorder
definition editor: YH

eye AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0000970
subclass of: adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: an AE that occurs in eye.
definition editor: YH
alternative term: eye disorder AE
has_MedDRA_id: 10015916
see also: HPO: HP_0000496
see also: SIDER: C0015397

autism AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of autism
definition editor: YH
alternative term: Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior.

sedimentation rate increased AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE which has an outcome of sedimentation rate increased
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
editor note: This term should be inferred to lab test abnormal.
definition editor: YH
alternative term: ESR
alternative term: erythrocyte sedimentation rate
alternative term: red blood cell sedimentation rate increased AE
alternative term: sedrate
comment: Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short.
comment: red blood cell sedimentation rate increased AE is an AE: sedimentation rate increased that has an increase in rate at which red blood cells precipitate in a period of 1 hour.

arthritis reactive AE
type: Class
subclass of: arthritis AE
definition: an arthritis AE that has an outcome of arthritis due to an infection in another part of the body
definition editor: DJ, SS, YH, DA
alternative term: reactive arthritis AE
alternative term: reiter's syndrome AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/16822921
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563769/
definition source: https://www.ncbi.nlm.nih.gov/pubmed/18436339
has_MedDRA_id: 10003267
has_MedDRA_id: 10038294

amblyopia AE
type: Class
subclass of: abnormal vision AE
definition: an abnormal vision AE which has an outcome of amblyopia
definition editor: YH
has_MedDRA_id: 10001906
see also: HPO: HP_0000646
see also: SIDER: C0002418

mental retardation AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that has an outcome of mental retardation
definition editor: YH
see also: HPO: HP_0001249
see also: SIDER: C0025362

erythema multiforme AE
type: Class
subclass of: rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a rash AE which shows red, target-shaped or "bulls-eye" patches or sores on the skin.
definition editor: YH, MW
definition source: WEB: http://kidshealth.org/parent/infections/skin/erythema_multiforme.html
definition source: WEB: https://en.wikipedia.org/wiki/Erythema_multiforme
has_MedDRA_id: 10015218
comment: The erythema multiforme rash usually begins on the arms, hands, legs, and feet, but you might also find it on the face, neck, and body. It also can affect the lips and inside the mouth. It usuallys follows an infection or drug exposure.
see also: HPO: HP_0010783
see also: SIDER: C0014742

SGOT increased AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a lab test abnormal AE that has an outcome of SGOT increased
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
comment: SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST).

SGPT increased AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a lab test abnormal AE that has an outcome of SGPT increased
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
comment: SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT).

thinking abnormality AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavioral and neurological AE that has an outcome of thinking abnormality
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, JX
has_MedDRA_id: 10043431

dyspepsia AE
type: Class
subclass of: abnormal digestion AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an abnormal digestion AE which has an outcome of dyspepsia
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10013946
comment: Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating.
see also: CTCAE: E10617
see also: HPO: HP_0002577
see also: NCIt: C26756
see also: SIDER: C0013395

anaphylactoid reaction AE
type: Class
subclass of: allergy AE
definition: an allergy AE which has an outcome of anaphylactoid reaction AE is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22293078
has_MedDRA_id: 10002198
has_MedDRA_id: 10002216
see also: HPO: HP_0100845
see also: SIDER: C0340865

gastrointestinal disorder AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0005409
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE which has an outcome of a gastrointestinal disorder
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
see also: HPO: HP_0011024
see also: SIDER: C0017178

ascites AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an edema AE that has an outcome of accumulation of fluid in the peritoneal cavity
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23296107
has_MedDRA_id: 10003445
see also: CTCAE: E10502
see also: HPO: HP_0001541
see also: NCIt: C2885
see also: SIDER: C0003962

serum sickness AE
type: Class
subclass of: hypersensitivity AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hypersensitivity AE which has an outcome of serum sickness
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, MW
has_MedDRA_id: 10040400
comment: Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III).
see also: CTCAE: E11276
see also: NCIt: C79718

injection-site abscess AE
type: Class
subclass of: injection-site AE
subclass of: abscess AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: an abscess AE which has an outcome of injection-site abscess
definition editor: YH

abnormal electroencephalogram result AE
type: Class
subclass of: behavioral and neurological test abnormal AE
definition: a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of a procedure that uses small, flat metal discs (electrodes) attached to your scalp to detect electrical activity in your brain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, EB
definition source: WEB: http://www.mayoclinic.com/health/eeg/MY00296
has_MedDRA_id: 10000130

vertigo AE
type: Class
subclass of: dizziness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a dizziness AE that has an outcome of vertigo
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10047340
comment: Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking.
see also: CTCAE: E10291
see also: HPO: HP_0002321
see also: NCIt: C38057
see also: SIDER: C0042571

cardiac arrest
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiac disorder AE that has an outcome of heartarrest, the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole.
definition editor: YH
alternative term: cardiopulmonary arrest
alternative term: circulatory arrest
alternative term: heart arrest AE
definition source: WEB: http://en.wikipedia.org/wiki/Myocardial_infarction
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cardiac+arrest
has_MedDRA_id: 10007515
has_MedDRA_id: 10007617
has_MedDRA_id: 10028596
see also: CTCAE: E10101
see also: NCIT: C50479

bronchitis AE
type: Class
subclass of: respiratory system inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002185
definition: a respiratory system inflammation AE which has an outcome of bronchitis
definition editor: YH
comment: Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes.
see also: HPO: HP_0002837
see also: SIDER: C0006277

grand malconvulsion AE
type: Class
subclass of: seizure AE
definition: a seizure AE that has an outcome of grand malconvulsion
definition editor: YH
comment: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process).

liver function test abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a liver related investigation result abnormal AE which shows an abnormal test result in a liver function test, indicating aberrant function of liver.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543).
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hepatic+function
has_MedDRA_id: 10019670
has_MedDRA_id: 10024690
see also: MP: MP_0000609

ear AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0001690
subclass of: adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an AE that occurs in ear.
definition editor: YH
alternative term: ear disorder AE
see also: HPO: HP_0000598
see also: SIDER: C0013447

viral infection AE
type: Class
subclass of: infection AE
definition: an infection AE that results in detrimental colonization of a host organism by virus
definition editor: YH, SS
alternative term: viral infection
definition source: WEB: http://en.wikipedia.org/wiki/Viral_infection
see also: HPO: HP_0005364
see also: SIDER: C0042769

lacrimation disorder AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of lacrimation disorder
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
comment: Lacrimation is the production, secretion, and shedding of tears.

jaundice AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE which has an outcome of jaundice, which is the clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: SS, YH
alternative term: icterus AE
definition source: WEB: http://en.wikipedia.org/wiki/Jaundice
has_MedDRA_id: 10023126
see also: HPO: HP_0000952
see also: MP: MP_0000611
see also: SIDER: C0022346

abscess AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE which shows an enclosed collection of liquefied tissue, known as pus, somewhere in the body. Abscess is the result of the body's defensive reaction to foreign material.
definition editor: YH
alternative term: abscessus
definition source: WEB: http://medical-dictionary.thefreedictionary.com/abscess
has_MedDRA_id: 10000269
comment: An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body.
see also: HPO: HP_0002722
see also: SIDER: C0000833

eye pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000970
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of eye pain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10015958
see also: CTCAE: E10376
see also: HPO: HP_0200025
see also: NCIt: C78287
see also: SIDER: C0151827

palpitation AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of palpitation
definition editor: YH
definition source: WEB: http://en.wikipedia.org/wiki/Palpitations
has_MedDRA_id: 10033557
comment: A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency.

tongue edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001723
definition: an edema AE which has an outcome of tongue edema
definition editor: YH, RR
alternative term: tongue oedema AE
alternative term: tongue swelling AE
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=97582
has_MedDRA_id: 10042727

ear pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001690
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of ear pain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'ear pain' was mentioned in 302 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10014020
see also: CTCAE: E10262
see also: HPO: HP_0010833
see also: NCIt: C37944
see also: SIDER: C0013456

angioedema AE
type: Class
subclass of: edema AE
definition: an edema AE which has an outcome of angioedema
definition editor: YH, SJ
alternative term: angioneurotic edema
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/hives-and-angioedema/basics/definition/con-20014815
has_MedDRA_id: 10002473
comment: Angioedema is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues often around the eyes and lips. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis.

rheumatoid arthritis AE
type: Class
subclass of: arthritis AE
definition: An arthritis AE that has the outcome of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body.
definition editor: YH
see also: HPO: HP_0005681
see also: SIDER: C0003873

immune system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002405
subclass of: adverse event
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002405
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an AE that occurs in immune system.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: immune system disorder AE
see also: HPO: HP_0002715
see also: SIDER: C0021053

antinuclear antibody present AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE which has an outcome of antinuclear antibody present
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'antinuclear antibody present'; is an adverse event that was mentioned in 288 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: anti-nuclear factor present
comment: The presence of anti-nuclear antibodies (ANAs) that are antibodies directed against contents of the cell nucleus. ANAs are present in higher than normal numbers in autoimmune disease. The ANA test measures the pattern and amount of autoantibody which can attack the body's tissues as if they were foreign material. Autoantibodies are present in low titers in the general population, but in about 5% of the population, their concentration is increased, and about half of this 5% have an autoimmune disease.

myelitis AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a nervous system AE which involves inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs.
definition editor: YH, MW
has_MedDRA_id: 10028524
see also: CTCAE: E12732
see also: NCIt: C26832

migraine AE
type: Class
subclass of: headache AE
definition: a headache AE that has an outcome of migraine
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'migraine'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: migraine headache
comment: A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit.
see also: HPO: HP_0002076
see also: SIDER: C0149931

thrombocytopenic purpura AE
type: Class
subclass of: purpura AE
definition: Thrombocytopenic purpura AE are purpura AE associated with a reduction in circulating blood platelets which can result from a variety of causes.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenic purpura'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10043561
see also: HPO: HP_0004829
see also: SIDER: C0857305

multiple sclerosis AE
type: Class
subclass of: immune system AE
definition: multiple sclerosis AE is an immune system disorder AE, or an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination.
definition editor: YH
alternative term: MS
alternative term: disseminated sclerosis
alternative term: encephalomyelitis disseminata
has_MedDRA_id: 10028245

amnesia AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a behavior and neurological AE that has an outcome of amnesia in a patient
definition editor: YH, MW
has_MedDRA_id: 10001949
comment: Amnesia is a short term memory condition in which memory is disturbed. In simple terms it is the loss of memory.
see also: HPO: HP_0002354
see also: SIDER: C0002622

incoordination AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of incoordination
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'incoordination' was mentioned in 261 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
comment: a lack of normal adjustment of muscular action so that the intended movement of the limb or other part is not made smoothly and harmoniously, and does not accurately achieve its objective. If the abnormality is hypermetric, the condition is referred to as ataxia. If it is inclined to weakness, e.g. knuckling at the turn, stumbling, failure to flex limbs properly, or to misdirection as in a proprioceptive deficit, it is called incoordination.

voice alteration AE
type: Class
subclass of: speech disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a speech disorder that has an outcome of voice alteration
definition editor: YH, MW
has_MedDRA_id: 10047681
see also: CTCAE: E13601
see also: NCIt: C61043

abortion AE
type: Class
subclass of: pregnancy AE
definition: a pregnancy AE that is the termination of a pregnancyby the removal or expulsion from the uterus of a fetus or embryo, resulting in or caused by its death.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'abortion'; is an adverse event that was mentioned in 257 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, SS
definition source: WEB: http://en.wikipedia.org/wiki/Abortion
has_MedDRA_id: 10000210

psychological shock AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that has an outcome of shock
definition editor: YH
alternative term: acute stress disorder AE
alternative term: acute stress reaction AE
alternative term: mental shock AE
has_MedDRA_id: 10001084
comment: Mental shock (or shock) is a psychological condition arising in response to a terrifying event. It should not be confused with the unrelated circulatory condition of shock.
comment: There are two types of shocks. Another is circulatory shock which is physiological with MedDRA ID of 10040560.

purpura AE
type: Class
subclass of: skin discoloration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin discoloration AE which has an outcome of purpura
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'purpura'; is an adverse event that was mentioned in 251 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, MW
Chinese translation: 紫癜
has_MedDRA_id: 10037549
comment: Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia. Reference: http://en.wikipedia.org/wiki/Purpura.
see also: HPO: HP_0000979
see also: SIDER: C0034150

bacterial infection AE
type: Class
subclass of: infection AE
definition: an infection AE that results in detrimental colonization of a host organism by bacteria
definition editor: YH, SS
alternative term: bacterial infection AE
definition source: WEB: http://en.wikipedia.org/wiki/Bacterial_infection
has_MedDRA_id: 10060945
see also: HPO: HP_0002718
see also: SIDER: C0004623

skin striae AE
type: Class
subclass of: skin AE
definition: a skin adverse event that has an outcome of skin striae that displays irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'skin striae'; is an adverse event that was mentioned in 247 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: stretch marks
alternative term: striae distensae
see also: HPO: HP_0001065
see also: SIDER: C0152459

acute brain syndrome AE
type: Class
subclass of: syndrome AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
definition: a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention.
definition editor: YH

coma AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of coma
definition editor: YH
has_MedDRA_id: 10010071
comment: Coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions.
see also: HPO: HP_0001259
see also: SIDER: C0009421

hyperkinesia AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event which has an outcome of hyperkinesia, an abnormal increase in muscular activity.
definition editor: YH
has_MedDRA_id: 10020651
see also: HPO: HP_0002487
see also: SIDER: C0424295

cardiovascular AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: occurs in
    some values from: UBERON_0004535
subclass of: adverse event
definition: an AE that occurs in cardiovascular system.
definition editor: YH
alternative term: cardiovascular disorder AE
has_MedDRA_id: 10007649
see also: HPO: HP_0001626
see also: SIDER: C0007222

encephalopathy AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a nervous system AE which has an outcome of encephalopathy, which is disorder or disease of the brain.
definition editor: YH, MW
has_MedDRA_id: 10014625
see also: HPO: HP_0007239
see also: SIDER: C0085584

urine abnormality AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE that has an outcome of urine abnormality AE
definition editor: YH
see also: HPO: HP_0011036
see also: SIDER: C0235639

gastroenteritis AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disorder AE which has an outcome of gastroenteritis, an inflammation occuring in the gastrointestinal tract that involves both the stomach and the small intestine, often results in diarrhea, vomiting and abdominal pain and cramping
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'gastroenteritis' was mentioned in 218 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/gastroenteritis
has_MedDRA_id: 10017888
see also: HPO: HP_0004386
see also: SIDER: C0017160

peripheral vascular disorder AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that has an outcome of peripheral vascular disorder
definition editor: YH
see also: HPO: HP_0005299
see also: SIDER: C0085096

urinary tract infection AE
type: Class
subclass of: OAE_0004456
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a urinary tract disoder AE that has an outcome of urnary tract infection AE
definition editor: YH
has_MedDRA_id: 10046571
see also: CTCAE: E11614
see also: HPO: HP_0000094
see also: NCIt: C50791
see also: SIDER: C0042029

increased salivation AE
type: Class
subclass of: abnormal salivary gland physiology AE
definition: an abnormal salivary gland physiology AE which has an outcome of increased salivation, meaning greater than normal amounts of flowing saliva
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'increased salivation' is an adverse event that was mentioned in 336 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
see also: MP: MP_0000622

depression AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has an outcome of depression. Depression causes a persistent feeling of sadness and loss of interest.
definition editor: YH, MW
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/depression/basics/definition/con-20032977
has_MedDRA_id: 10012378
see also: HPO: HP_0000716
see also: SIDER: C0011570

diabetes mellitus AE
type: Class
subclass of: glucose homeostasis AE
definition: a glucose homeostasis AE which has an outcome of diabetes mellitus
definition editor: YH
alternative term: diabetes AE
has_MedDRA_id: 10012601
comment: Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia).
see also: HPO: HP_0000819
see also: SIDER: C0011849

laryngitis AE
type: Class
subclass of: respiratory system inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001737
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system inflammation AE which has an outcome of laryngitis
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngitis'; is an adverse event that was mentioned in 190 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10023874
comment: Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice because of irritation to the vocal folds (vocal cords).
see also: CTCAE: E11435
see also: HPO: HP_0001600
see also: NCIt: C26811
see also: SIDER: C0023067

generalized spasm AE
type: Class
subclass of: muscle spasm AE
definition: a muscle spasm AE which has an outcome of generalized spasm, which is an involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH).
definition editor: YH

obsolete: reflexes decreased AE
type: Class
subclass of: ObsoleteClass
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'reflexes decreased'; is an adverse event that was mentioned in 178 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: hyporeflexia AE
comment: Obsoleted because of duplication. It's an alternative term of hyporeflexia AE now.
comment: a movement disorder AE that has an outcome of reflexes decreased, an abnormal decrease in an involuntary response to a peripheral stimulus

dry mouth AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a digestive system AE which has an outcome of dry mouth, which is dryness of the mouth resulting from reduced salivary secretion
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'dry mouth'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: xerostomia
has_MedDRA_id: 10013781
see also: CTCAE: E10578
see also: HPO: HP_0000217
see also: NCIt: C26917
see also: SIDER: C0043352

optic neuritis AE
type: Class
subclass of: neuritis AE
definition: a neuritis AE which has an outcome of optic neuritis
definition editor: YH
has_MedDRA_id: 10030942
see also: HPO: HP_0100653
see also: SIDER: C0029134

thrombocythemia AE - OBSOLETE (due to duplication)
type: Class
subclass of: ObsoleteClass
definition: a cardiovascular disorder AE that has an outcome of thrombocythemia
definition editor: YH
comment: Thrombocythemia (primary thrombocythemia) is a disorder in which excess platelets are produced, leading to abnormal blood clotting or bleeding.

epistaxis AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has an outcome of epistaxis
definition editor: YH, MW
alternative term: nosebleed
has_MedDRA_id: 10015090
comment: Epistaxis is the relatively common occurrence of hemorrhage from the nose, usually noticed when the blood drains out through the nostrils.
see also: HPO: HP_0000421
see also: SIDER: C0014591

lupus AE
type: Class
subclass of: autoimmune disorder AE
definition: a syndrome AE that displays a lupus syndrome. Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. This results in symptoms such as inflammation, swelling, and damage to joints, skin, kidneys, blood, the heart, and lungs.
definition editor: YH, JX
alternative term: lupus syndrome AE
alternative term: 狼疮样综合征
definition source: WEB: http://www.medicalnewstoday.com/info/lupus/

photophobia AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an eye disorder AE which has an outcome of photophobia
definition editor: YH
has_MedDRA_id: 10034960
comment: Photophobia is a symptom of excessive sensitivity to light and the aversion to sunlight or well-lit places. In medical terms it is not fear, but an experience of discomfort or pain to the eyes due to light exposure.
see also: CTCAE: E10416
see also: HPO: HP_0000613
see also: NCIt: C28210
see also: SIDER: C0085636

abnormal salivary gland physiology AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE which has an outcome of abnormal salivary gland physiology, which is any functional anomaly of any of the glands in the mouth that secrete saliva
see also: MP: MP_0005310

hallucination AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has an outcome of hallucination
definition editor: YH, MW
alternative term: hallucinations AE
has_MedDRA_id: 10019063
has_MedDRA_id: 10019077
comment: A hallucination, in the broadest sense, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space.
see also: CTCAE: E12919
see also: HPO: HP_0000738
see also: NCIt: C37961
see also: SIDER: C0018524

tongue disorder
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001723
definition: a digestive system AE which has an outcome of tongue disorder
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue disorder'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
see also: HPO: HP_0000157
see also: SIDER: C0040409

neuralgia AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of neuralgia
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'neuralgia'; is an adverse event that was mentioned in 155 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, MW
has_MedDRA_id: 10029223
comment: Neuralgia or neuropathic pain can be defined most simply as non-nociceptive pain. Neuralgia is pain produced by a change in neurological structure or function. Unlike nociceptive pain, Neuralgia exists with no continuous nociceptive input. Neuralgia falls into two categories: central Neuralgia and peripheral Neuralgia.
see also: HPO: HP_0003489
see also: SIDER: C0027796

lung edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002048
definition: an edema AE which has an outcome of lung edema
definition editor: YH

circumoral paresthesia AE
type: Class
subclass of: paresthesia AE
definition: a paresthesia AE that occurs around the mouth.
definition editor: YH
see also: HPO: HP_0003401
see also: SIDER: C0151838

thirst AE
type: Class
subclass of: abnormal fluid regulation AE
definition: an abnormal fluid regulation AE which has an outcome of thirst
definition editor: YH
has_MedDRA_id: 10043458
comment: Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance.
see also: HPO: HP_0001959
see also: SIDER: C0039971

bone AE
type: Class
subclass of: musculoskeletal or connective tissue AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002481
definition: a musculoskeletal system AE that occurs in the bone
definition editor: YH
alternative term: bone disorder
has_MedDRA_id: 10005956
see also: HPO: HP_0000924
see also: SIDER: C0005940

fetal disorder AE
type: Class
subclass of: perinatal AE
definition: a perinatal AE that displays fetal disorder.
definition editor: YH

emotional liability AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of emotional liability
definition editor: YH

muscle spasm AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event which has an outcome of muscle spasm, which is an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Spasm
has_MedDRA_id: 10028334
see also: MP: MP_0000743

tendon disorder AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0000043
subclass of: connective tissue disorder AE
definition: a connective tissue disorder AE that occurs at the location of tendon
editor note: A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'tendon disorder'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
comment: Tendon disorder is a medical condition that results in a tendon not functioning normally.

hostility AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of hostility
definition editor: YH
has_MedDRA_id: 10020400

visual field defect AE
type: Class
subclass of: eye AE
definition: an eye disorder AE which has an outcome of visual field defect
definition editor: SS, YH
alternative term: visual impairment AE
definition source: WEB: http://en.wikipedia.org/wiki/Visual_impairment
has_MedDRA_id: 10047555
has_MedDRA_id: 10047571

myopathy AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event which has an outcome of myopathy AE, an abnormal condition or disease of the skeletal muscle
has_MedDRA_id: 10028641
see also: HPO: HP_0003198
see also: MP: MP_0000751
see also: SIDER: C0026848

apathy AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of apathy state
definition editor: YH
alternative term: impassivity
alternative term: perfunctoriness
has_MedDRA_id: 10002942
comment: Apathy is a state of indifference, or the suppression of emotions such as concern, excitement, motivation and passion. An apathetic individual has an absence of interest or concern to emotional, social, or physical life. They may also exhibit an insensibility or sluggishness.
see also: HPO: HP_0000741
see also: SIDER: C0085632

hemiplegia AE
type: Class
subclass of: paralysis AE
definition: a paralysis AE that has an outcome of hemiplegia
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'hemiplegia'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10019468
comment: Hemiplegia is total paralysis of the arm, leg, and trunk on the same side of the body. Hemiplegia is more severe than hemiparesis, wherein one half of the body is weakened but not paralysed.
see also: HPO: HP_0002301
see also: SIDER: C0018991

pustular rash AE
type: Class
subclass of: rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
definition: a rash AE that is characterized by a circumscribed and elevated skin lesion filled with pus.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'pustular rash'; is an adverse event that was mentioned in 128 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: rash pustular AE
has_MedDRA_id: 10037888
see also: CTCAE: E11545
see also: NCIt: C80119

blood creatine phosphokinase level increased AE
type: Class
subclass of: blood creatine phosphokinase level abnormal AE
definition: a blood creatine phosphokinase level abnormal AE that is characterized by an increased level of creatine phosphokinase (CPK) or phosphocreatine kinase, an enzyme expressed by various tissue types that catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP)
definition editor: YH, EB
alternative term: elevated serum creatine phosphate kinase AE
has_MedDRA_id: 10005470

intracranial hypertension AE
type: Class
subclass of: hypertension AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0003128
definition: a hypertension AE that has an outcome of elevated pressure in the skull.
definition editor: YH, SS
definition source: WEB: http://www.ihrfoundation.org/intracranial/hypertension/info/C16
has_MedDRA_id: 10049977

sensorimotor painful neuropathy AE
type: Class
subclass of: sensory neuropathy AE
definition: a sensory neuropathy AE which shows a painful neuropathy characterized by damage to sensory and motor nerves
definition editor: AG, YH

abnormal stool AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE which has an outcome of abnormal stool
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal stools' was mentioned in 111 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH

bone pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of bone pain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'bone pain' was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, MW
has_MedDRA_id: 10006002
see also: HPO: HP_0002653
see also: SIDER: C0151825

cerebrovascular accident AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that comes with cerebrovascular accident
definition editor: YH
alternative term: stroke
has_MedDRA_id: 10008190
comment: Cerebrovascular accident: The sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A CVA is also referred to as a stroke.
see also: HPO: HP_0001297
see also: SIDER: C0038454

parotid gland enlargement AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE which has an outcome of parotid gland enlargement
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'parotid gland enlargement' was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10034023

flatulence AE
type: Class
subclass of: movement disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a movement disorder AE that has an outcome of flatulence
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'flatulence' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
has_MedDRA_id: 10016766
comment: Flatulence is the production of a mixture of gases in the digestive tract of mammals or other animals that are byproducts of the digestion process. Such a mixture of gases is known as flatus, and is expelled from the rectum in a process colloquially referred to as "passing gas" or "farting".
see also: CTCAE: E10697
see also: HPO: HP_0011024
see also: NCIt: C37954
see also: SIDER: C0016204

liver damage AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE which has an outcome of liver damage
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'liver damage' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH

sore throat AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000341
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a respiratory system AE which has an outcome of sore throat
definition editor: YH, MW
has_MedDRA_id: 10041367
see also: CTCAE: E13575
see also: NCIt: C50747

paralysis AE
type: Class
subclass of: movement disorder AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002385
definition: a movement disorder AE that results in the loss of power of voluntary movement in a muscle through injury or disease of its nerve supply
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'paralysis' is an adverse event that was mentioned in 574 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: SS, YH
definition source: WEB: https://www.nlm.nih.gov/medlineplus/paralysis.html
Chinese translation: 瘫痪
has_MedDRA_id: 10033799
see also: HPO: HP_0010549
see also: MP: MP_0000753
see also: SIDER: C0522224

aseptic necrosis bone AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of cellular death of bone components due to interupption of blood supply
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/avascular+necrosis
has_MedDRA_id: 10003460

weight loss AE
type: Class
subclass of: physical examination result abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a physical examination result abnormal AE that has an outcome of weight loss, which is the progressive reduction of body weight below normal average for age
definition editor: MW, YH
alternative term: weight decreased AE
has_MedDRA_id: 10047895
has_MedDRA_id: 10047900
see also: CTCAE: E12228
see also: MP: MP_0001263
see also: NCIt: C3445

ataxia AE
type: Class
subclass of: movement disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'ataxia' is an adverse event that was mentioned in 555 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, MW
has_MedDRA_id: 10003591
comment: a movement disorder AE that has an outcome of ataxia, inability to coordinate voluntary muscular movements
see also: HPO: HP_0001251
see also: MP: MP_0001393
see also: SIDER: C0004134

skin AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002097
subclass of: hair, skin or nail AE
definition: a hair, skin, and nail AE that occurs in skin.
definition editor: YH
definition source: WEB: http://www.thefreedictionary.com/skin+disorder
has_MedDRA_id: 10040831

abnormal gait AE
type: Class
subclass of: movement disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a movement disorder AE that has an outcome of unusual or distinctive way of walking
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal gait' is an adverse event that was mentioned in 998 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543).
definition editor: SS, YH
alternative term: gait disturbance AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21224774
has_MedDRA_id: 10017577
see also: CTCAE: E11112
see also: MP: MP_0001406
see also: NCIt: C78303

dehydration AE
type: Class
subclass of: abnormal fluid regulation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal fluid regulation AE which has an outcome of dehydration, which is an excessive water loss from the body or from an organ or bodily part
definition editor: YH, SS, MW
alternative term: hypohydration
has_MedDRA_id: 10012174
see also: HPO: HP_0001944
see also: MP: MP_0001429
see also: SIDER: C0011175

abnormal fluid regulation AE
type: Class
subclass of: homeostasis AE
definition: a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid
see also: MP: MP_0001784

hyperglycemia AE
type: Class
subclass of: glucose homeostasis AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood glucose increased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a glucose homeostasis AE which has an outcome of hyperglycemia, which is an abnormally high concentration of glucose in the blood; generally refers to a pathological state
definition editor: YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hyperglycemia
has_MedDRA_id: 10020635
has_MedDRA_id: 10020639
see also: CTCAE: E12276
see also: MP: MP_0001559
see also: NCIt: C26797

abnormal circulating bilirubin level AE
type: Class
subclass of: homeostasis AE
definition: a homeostasis AE which has an outcome of abnormal ciculating bilirubin level, which is aberrant concentration in the blood of this yellow heme breakdown product
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'bilirubinemia'; is an adverse event that was mentioned in 221 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
see also: MP: MP_0001569

cyanosis AE
type: Class
subclass of: skin AE
definition: a skin adverse event that has an outcome of cyanosis, a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'cyanosis' is an adverse event that was mentioned in 1,804 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543).
has_MedDRA_id: 10011703
see also: HPO: HP_0000961
see also: MP: MP_0001575
see also: SIDER: C0010520

anemia AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hematopoietic system AE which has an outcome of anemia, which is less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs
alternative term: anaemia AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001586/
has_MedDRA_id: 10002034
has_MedDRA_id: 10002272
see also: CTCAE: E10010
see also: MP: MP_0001577
see also: NCIt: C2869

hypotension AE
type: Class
subclass of: abnormal blood pressure AE
subclass of: Restriction
  on property: is evidence of
  some values from: vasodilatation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states
definition editor: YH, MW
alternative term: blood pressure decreased, low blood pressure
has_MedDRA_id: 10005734
has_MedDRA_id: 10021097
see also: CTCAE: E13791
see also: HPO: HP_0002615
see also: MP: MP_0001596
see also: NCIt: C3128
see also: SIDER: C0020649

irregular heartbeat AE
type: Class
subclass of: arrhythmia AE
definition: an arrhythmia AE that has an outcome of uneven timing of heart contraction
see also: MP: MP_0001636

electrolyte blood test abnormal AE
type: Class
subclass of: electrolyte lab test abnormal AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000178
definition: an electrolyte lab test abnormal AE that shows an abnormal level of an electrolyte in the blood
definition editor: YH, MW

abnormal digestion AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy
see also: MP: MP_0001664

homeostasis AE
type: Class
subclass of: adverse event
definition: an AE that occurs in the homeostasis system.
comment: anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues
see also: MP: MP_0001764

edema AE
type: Class
subclass of: abnormal fluid regulation AE
definition: an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues
alternative term: oedema, swelling, dropsy
definition source: WEB: http://en.wikipedia.org/wiki/Oedema
definition source: WEB: http://en.wikipedia.org/wiki/Swelling_(medical)
has_MedDRA_id: 10016807
has_MedDRA_id: 10030095
has_MedDRA_id: 10042674
see also: MP: MP_0001785

inflammation AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Inflammation
has_MedDRA_id: 10061218
see also: HPO: HP_0007891
see also: MP: MP_0001846
see also: SIDER: C0021368

brain inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
definition: an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
see also: MP: MP_0001847

increased susceptibility to otitis media AE
type: Class
subclass of: ear AE
definition: an ear disorder AE which has an outcome of increased susceptibility to otitis media, which is greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection
see also: MP: MP_0001850

eye inflammation AE
type: Class
subclass of: eye AE
definition: an eye disorder AE which has an outcome of eye inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the eye
has_MedDRA_id: 10015943
see also: HPO: HP_0100533
see also: MP: MP_0001851
see also: SIDER: C0239429

conjunctivitis AE
type: Class
subclass of: eye inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an eye inflammation AE which has an outcome of conjunctivitis, which is inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball
has_MedDRA_id: 10010741
see also: CTCAE: E10355
see also: HPO: HP_0000509
see also: MP: MP_0001852
see also: NCIt: C34504
see also: SIDER: C0009763

liver inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002107
definition: an inflammation AE that shows a local accumulation of fluid, plasma proteins, and leukocytes in the liver
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatitis' was mentioned in 387 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH, JX
see also: MP: MP_0001860

lung inflammation AE
type: Class
subclass of: respiratory system inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002048
definition: aa inflammation AE which has an outcome of lung inflammation, a local accumulation of fluid, plasma proteins, and leukocytes in the lung
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543).
see also: MP: MP_0001861

respiratory system inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001004
definition: an inflammation AE which occurs in the respiratory system, which is reflected with the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system
see also: MP: MP_0002405

vasculitis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000055
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel
editor note: It's an inflammation.
definition editor: YH, MW
has_MedDRA_id: 10047115
see also: HPO: HP_0002633
see also: MP: MP_0001864
see also: SIDER: C0042384

salivary gland inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001044
definition: an inflammation AE which has an outcome of salivary gland inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland
see also: MP: MP_0001870

sinusitis AE
type: Class
subclass of: respiratory system inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system inflammation AE which has an outcome of sinus inflammation, an inflammation of paranasal sinuses, which may be due to infection, allergy, or autoimmune issues.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'sinusitis'; is an adverse event that was mentioned in 298 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: SS, YH, RR
alternative term: sinus inflammation AE
definition source: WEB: http://en.wikipedia.org/wiki/Sinusitis
has_MedDRA_id: 10040753
see also: CTCAE: E11563
see also: HPO: HP_0000246
see also: MP: MP_0001872
see also: NCIt: C35024
see also: SIDER: C0037199

allergy AE
type: Class
subclass of: hypersensitivity AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hypersensitivity AE which results in an allergic response showing a marked increase in reactivity to an antigen upon subsequent exposure.
definition editor: JX, LW, YH
alternative term: allergic reaction AE
alternative term: allergic response AE
alternative term: anaphylactic reaction AE
definition source: WEB: http://en.wikipedia.org/wiki/Allergy
Chinese translation: 变态反应
Chinese translation: 过敏反应
has_MedDRA_id: 10001718
has_MedDRA_id: 10001738
see also: CTCAE: E11248
see also: MP: MP_0001878
see also: NCIt: C3114

abnormal cerebrospinal fluid production AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE which has an outcome of abnormal cerebrospinal fluid production, an anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord
see also: MP: MP_0001911

nervous system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0001016
subclass of: adverse event
definition: an AE that occurs in nervous system.
definition editor: KY, YH
alternative term: nervous system disorder AE
definition source: URL: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/overview_of_nervous_system_disorders_85,P00799/
has_MedDRA_id: 10029202
see also: MP: MP_0003633

abnormal respiration AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
editor note: Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He
see also: MP: MP_0001943

apnea AE
type: Class
subclass of: abnormal respiration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal respiration AE which has an outcome of apnea, temporary cessation of breathing; sometimes episodic
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'apnea' is an adverse event that was mentioned in 1,618 VAERS reports (1.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: JX, YH, MW
alternative term: MedDRA: 10002974 is for "apnoea"; MedDRA: 10002972 is for "apnea".
alternative term: apnoea AE
alternative term: respiratory arrest AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/apnea
see also: CTCAE: E13306
see also: MP: MP_0001957
see also: NCIt: C26698
see also: UMLS CUI: C0003578

deafness AE
type: Class
subclass of: ear AE
definition: an ear disorder AE which has an outcome of deafness, which is an inability to hear
has_MedDRA_id: 10011878
see also: HPO: HP_0000365
see also: MP: MP_0001967
see also: SIDER: C0011053

gustatory system AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: occurs in
    some values from: UBERON_0001033
subclass of: adverse event
definition: an adverse event that occurs in a gustatory system
definition editor: YH, JX
see also: MP: MP_0001985

taste sensitivity AE
type: Class
subclass of: gustatory system AE
definition: a gustatory system AE which has an outcome of taste sensitivity, or changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system
see also: MP: MP_0001986

polyuria AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE that has an outcome of excessive or abnormally large production or passage of urine.
definition editor: LW, ML, JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Polyuria
Chinese translation: 多尿
has_MedDRA_id: 10036142

blindness AE
type: Class
subclass of: abnormal vision AE
definition: an abnormal vision AE which has an outcome of blindness, which is loss of the sense of sight
has_MedDRA_id: 10005169
see also: HPO: HP_0000618
see also: MP: MP_0002001
see also: SIDER: C0456909

abnormal vision AE
type: Class
subclass of: eye AE
definition: an eye disorder AE which has an outcome of abnormal vision, which is an inability or decreased ability to see
see also: MP: MP_0002090

seizure AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a behavior and neurological AE that shows a sudden surge of electrical activity in the brain.
definition editor: YH, JX, YH
definition source: WEB: http://www.healthline.com/symptom/seizures
Chinese translation: 突然发作
has_MedDRA_id: 10039906
has_MedDRA_id: 10039910
see also: CTCAE: E12804
see also: MP: MP_0002064
see also: NCIt: C2962

behavioral and neurological AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: has participant quality
    some values from: OAE_0003230
subclass of: adverse event
definition: an adverse event that has an outcome of an abnormal behavior and neurological phenotype.
definition editor: YH, JX
alternative term: behavior AE
alternative term: behavioral AE
alternative term: behavioral disorder AE
alternative term: disruptive behavioral disorder AE
definition source: WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/
comment: any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls
see also: MP: MP_0004924

movement disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements
has_MedDRA_id: 10028035
see also: HPO: HP_0100022
see also: MP: MP_0002066
see also: SIDER: C0026650

sensory capability AE
type: Class
subclass of: behavioral and neurological AE
comment: a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus
see also: MP: MP_0002067

glucose homeostasis AE
type: Class
subclass of: homeostasis AE
definition: a homeostasis AE which has an outcome of glucose homeostasis, which is an anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues
see also: MP: MP_0002078

hypersensitivity AE
type: Class
subclass of: immune system AE
definition: Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal.
definition editor: JX, LW, YH
alternative term: hypersensitivity reaction AE
definition source: WEB: http://en.wikipedia.org/wiki/Hypersensitivity
Chinese translation: 超敏反应
has_MedDRA_id: 10020751
see also: HPO: HP_0100326
see also: MP: MP_0002148
see also: SIDER: C0020517

muscular atrophy AE
type: Class
subclass of: muscle AE
definition editor: YH
comment: Muscle atrophy is a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation.
comment: a muscle adverse event AE which has an outcome of muscular atrophy.
see also: MP: MP_0002269

hyperventilation AE
type: Class
subclass of: abnormal respiration AE
definition: an abnormal respiration AE which has an outcome of hyperventilation, i.e., increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'Petechiae' was mentioned in 510 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
has_MedDRA_id: 10020910
see also: HPO: HP_0002883
see also: MP: MP_0002320
see also: SIDER: C0020578

hypoventilation AE
type: Class
subclass of: abnormal respiration AE
definition: an abnormal respiration AE which has an outcome of hypoventilation, i.e., reduced alveolar ventilation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoventilation' is an adverse event that was mentioned in 321 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: QL, YH
alternative term: respiratory depression AE
definition source: WEB: https://en.wikipedia.org/wiki/Hypoventilation
Chinese translation: 呼吸抑制
has_MedDRA_id: 10021133
has_MedDRA_id: 10038678
see also: HPO: HP_0007110
see also: MP: MP_0002321
see also: SIDER: C0398353

hematopoietic system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002390
subclass of: adverse event
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002390
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an adverse event which occurs in a hematopoietic system, which is any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells
see also: MP: MP_0002396

mydriasis AE
type: Class
subclass of: eye AE
definition: an eye disorder AE which has an outcome of mydriasis, which is dilation of one or both pupils regardless of light conditions
has_MedDRA_id: 10028521
see also: HPO: HP_0011499
see also: MP: MP_0002546
see also: SIDER: C0026961

increased heart rate AE
type: Class
subclass of: arrhythmia AE
definition: an arrhythmia AE that has an outcome of greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
alternative term: tachycardia
definition source: WEB: http://en.wikipedia.org/wiki/Tachycardia
has_MedDRA_id: 10019303
see also: MP: MP_0002626

hyperresponsive to tactile stimuli AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of exaggerated reflex action
see also: MP: MP_0002738

opisthotonus AE
type: Class
subclass of: muscle spasm AE
subclass of: movement disorder AE
definition: a muscle spasm AE that has an outcome of opisthotonus
definition editor: YH
has_MedDRA_id: 10030899
comment: opisthotonus is a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward
see also: HPO: HP_0002179
see also: MP: MP_0002880
see also: SIDER: C0151818

joint inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000982
definition: An joint disorder AE that has an outcome of joint inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the joints
definition editor: YH
see also: MP: MP_0002933

increased lactate dehydrogenase level AE
type: Class
subclass of: abnormal enzyme level AE
definition: an abnormal enzyme level AE which has an outcome of incraesed lactate dehydrogenase level, which is greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate
see also: MP: MP_0002944

increased circulating alkaline phosphatase level AE
type: Class
subclass of: abnormal enzyme level AE
definition: an abnormal enzyme level AE which has an outcome of increased circulating alkaline phophatase level, which is an elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood
see also: MP: MP_0002968

arthritis AE
type: Class
subclass of: joint inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: A joint inflammation AE that has an outcome of arthritis, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures
definition editor: YH, MW
Chinese translation: 关节炎
has_MedDRA_id: 10003246
see also: HPO: HP_0001369
see also: MP: MP_0002993
see also: SIDER: C0003864

dysphagia AE
type: Class
subclass of: digestive system AE
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE which has an outcome of dysphagia, which is a behavior and neurological AE that has an outcome of difficulty in swallowing food or liquid
has_MedDRA_id: 10013950
see also: CTCAE: E10621
see also: HPO: HP_0002015
see also: MP: MP_0003158
see also: NCIt: C2980
see also: SIDER: C0011168

decreased lateral semicircular canal size AE
type: Class
subclass of: ear AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001843
definition: an ear disorder AE which has an outcome of decreased lateral semicircular canal size, which is small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance
see also: MP: MP_0003162

platelet count decreased AE
type: Class
subclass of: platelet count abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a hematopoietic system AE which has an outcome of decreased platelet count, which is fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation
definition editor: SS, YH
alternative term: decreased platelet cell number AE
has_MedDRA_id: 10035528
see also: CTCAE: E12207
see also: HPO: HP_0001873
see also: MP: MP_0003179
see also: NCIt: C3408
see also: SIDER: C0392386

nausea AE
type: Class
subclass of: abnormal digestion AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit
has_MedDRA_id: 10028813
see also: CTCAE: E10878
see also: HPO: HP_0002018
see also: MP: MP_0003259; MDR: 10028813
see also: NCIt: C3258
see also: SIDER: C0027497

vomiting AE
type: Class
subclass of: abnormal digestion AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
alternative term: regurgitation AE
has_MedDRA_id: 10047700
comment: an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity
see also: CTCAE: E11068
see also: HPO: HP_0002013
see also: MP: MP_0003260; MDR: 10047700
see also: NCIt: C3442
see also: SIDER: C0042963

constipation AE
type: Class
subclass of: abnormal defecation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal defecation AE that has an outcome of constipation, which is incomplete, infrequent or difficult evacuation of fecal matter
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'constipation'; is an adverse event that was mentioned in 242 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
alternative term: infrequent bowel movements AE
has_MedDRA_id: 10010774
see also: CTCAE: E10562
see also: HPO: HP_0002019
see also: MP: MP_0003267
see also: NCIt: C37930
see also: SIDER: C0009806

abnormal defecation AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces
see also: MP: MP_0003866

urinary incontinence AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a urinary system AE that has an outcome of the symptom of urinary incontinence, which is the inability to control the urinary excretory functions.
definition editor: YH, MW
alternative term: MedDRA: 10046543
definition source: WEB: http://www.nlm.nih.gov/medlineplus/urinaryincontinence.html
see also: CTCAE: E13042
see also: HPO: HP_0000020
see also: MP: MP_0003280
see also: NCIt: C78497
see also: SIDER: C0042024

clonus AE
type: Class
subclass of: muscle AE
definition: clonus AE is a series of involuntary, rhythmic, muscular contractions and relaxations.
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Clonus
has_MedDRA_id: 10009346
comment: clonus AE causes large motions that are usually initiated by a reflex.

pallor AE
type: Class
subclass of: skin discoloration AE
definition: a skin discoloration AE which has an outcome of pallor, an unnatural paleness to the skin, generally attributable to anemia
has_MedDRA_id: 10033546
see also: HPO: HP_0008361
see also: MP: MP_0003717
see also: SIDER: C0030232

tinnitus AE
type: Class
subclass of: hearing disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an hearing disorder AE that shows a persistent sensation of buzzing, ringing, clicking, or other noises in the ear
has_MedDRA_id: 10043882
see also: CTCAE: E10287
see also: HPO: HP_0000360
see also: MP: MP_0003741
see also: NCIt: C50772
see also: SIDER: C0040264

stomatitis AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: a digestive system AE which has an outcome of stomatitis, which is an inflammation of the mucous lining of the mouth
alternative term: This is a type of inflammation.
definition source: WEB: http://medical-dictionary.thefreedictionary.com/stomatitis
has_MedDRA_id: 10042128
see also: HPO: HP_0010280
see also: MP: MP_0003746
see also: SIDER: C0038362

mouth mucosal ulceration AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: a digestive system AE which has an outcome of mouth mucosal ulceration, which is lesions through the mucous membrane of the mouth, usually associated with loss of tissue
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'mouth ulceration' was mentioned in 246 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
see also: MP: MP_0003747

abnormal muscle tone AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event AE that has an outcome of abnormal muscle tone, which is an anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation
definition editor: YH
see also: MP: MP_0004142

hypertonia AE
type: Class
subclass of: abnormal muscle tone AE
definition: an abnormal muscle tone AE which has an outcome of hypertonia, which is increased muscle tension resulting in stiffness of the muscles in the resting state
definition editor: YH
has_MedDRA_id: 10020852
see also: HPO: HP_0001276
see also: MP: MP_0004143
see also: SIDER: C0026826

hypotonia AE
type: Class
subclass of: abnormal muscle tone AE
definition: an abnormal muscle tone AE which has an outcome of hypotonia, which is decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness
definition editor: YH
has_MedDRA_id: 10021118
see also: HPO: HP_0009062
see also: MP: MP_0004144
see also: SIDER: C0026827

myositis AE
type: Class
subclass of: muscle inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscle inflammation AE which has an outcome of myositis, which is an inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle
definition editor: YH, MW
has_MedDRA_id: 10028653
see also: HPO: HP_0009071
see also: MP: MP_0004510
see also: SIDER: C0027121

muscle inflammation AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event which has an outcome of muscle inflammation, which is a local accumulation of fluid, plasma proteins, and leukocytes in muscle
definition editor: YH
see also: MP: MP_0004511

lymphocyte count increased AE
type: Class
subclass of: lymphocyte count abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
definition: a lymphocyte count abnormal AE that has an outcome of greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'lymphocytosis'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
definition editor: EB
alternative term: increased lymphocyte cell number AE
alternative term: lymphocyte cell number increased AE
has_MedDRA_id: 10025258
see also: CTCAE: E12195
see also: MP: MP_0005013
see also: NCIt: C34791

diarrhea AE
type: Class
subclass of: abnormal defecation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel
alternative term: diarrhoea AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/diarrhea
has_MedDRA_id: 10012735
see also: CTCAE: E10572
see also: MP: MP_0005036
see also: NCIt: C2987

hypoxia AE
type: Class
subclass of: homeostasis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a homeostasis AE which has an outcome of hypoxia, which is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases
definition editor: YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypoxia
has_MedDRA_id: 10021143
see also: HPO: HP_0002795
see also: MP: MP_0005039
see also: SIDER: C0242184

sepsis AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: an infectious adverse event which has an outcome of the presence of various pathogenic organisms, or their toxins, in the blood or tissues that results in the infections in blood stream.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'sepsis' was mentioned in 416 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
definition editor: SS
has_MedDRA_id: 10040047
see also: CTCAE: E11560
see also: HPO: HP_0002718
see also: MP: MP_0005044
see also: NCIt: C3364
see also: SIDER: C0243026

hematuria AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a urinary system AE that results in the presence of blood in the urine
definition editor: YH, SJ, MW
alternative term: UMLS CUI: C0018965 (hematuria AND haematuria); UMLS CUI: C0947999 (blood urine presence)
alternative term: blood urine
alternative term: blood urine presence
alternative term: haematuria AE
definition source: WEB: http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/
has_MedDRA_id: 10018867
has_MedDRA_id: 10018870
has_MedDRA_id: 10019450
has_exact_synonym: hematuria
comment: Hematuria AE can be caused by menstruation, vigorous exercise, sexual activity, viral illness, trauma, or infection, such as a urinary tract infection (UTI), along with more serious disorders such as cancer, disease, and clotting.
see also: CTCAE: E13000
see also: MP: MP_0005161
see also: NCIt: C3090

abnormal enzyme level AE
type: Class
subclass of: homeostasis AE
definition: a homeostasis AE which has an outcome of abnormal enzyme level, which is an altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances
see also: MP: MP_0005319

decreased heart rate AE
type: Class
subclass of: arrhythmia AE
definition: an arrhythmia AE that has an outcome of fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
definition editor: YH, JX
alternative term: heart rate decreased AE
has_MedDRA_id: 10019301
see also: MP: MP_0005333

urinary system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0001008
subclass of: adverse event
definition: an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine
definition editor: YH
see also: MP: MP_0005502

hypothermia AE
type: Class
subclass of: abnormal body temperature AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an abnormal body temperature AE which has an outcome of decreased body temperature, which is less than the level of heat natural to a living being
definition editor: YH, SJ
alternative term: decreased body temperature AE
has_MedDRA_id: 10021113
comment: Hypothermia AE is a medical emergency that occurs when your body loses heat faster than it can produce heat, causing a dangerously low body temperature.
see also: CTCAE: E11122
see also: MP: MP_0005534
see also: NCIt: C78351

abnormal body temperature AE
type: Class
subclass of: homeostasis AE
definition: a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being
see also: MP: MP_0005535

neuritis AE
type: Class
subclass of: neuropathy AE
definition: a peripheral neuropathy AE which has an outcome of neuritis, the local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord
has_MedDRA_id: 10029240
see also: MP: MP_0006082

double vision AE
type: Class
subclass of: abnormal vision AE
alternative term: diplopia AE
has_MedDRA_id: 10013036
comment: an abnormal vision AE which has an outcome of double vision, which is two images perceived when only a single object is present
see also: MP: MP_0006150

hypochromic anemia AE
type: Class
subclass of: anemia AE
definition: an anemia AE which has an outcome of hypochromic anemia, which is a hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs
see also: MP: MP_0008387

investigation result abnormal AE
type: Class
subclass of: adverse event
definition: an adverse event that is indicated by an abnormal result of an investigation that uses some laboratory equipment, device, or medical technology.
editor note: This term is used to replace 'lab test abnormal AE'. The reason for this is that some test, like X-ray test, is not considered by many physicians as a lab test. Therefore, we have used this new term to cover a broader scope. All terms asserted under this term represent the investigation results without defined conclusion of disease.
definition editor: EB, SS, YH
alternative term: laboratory test abnormal
has_MedDRA_id: 10061253

nervous AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of nervous
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'nervousness' is an adverse event that was mentioned in 583 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543).
comment: increased, skittish, behavior induced by stimulation such as handling, touching or noise
see also: MP: MP_0008912

ecchymosis AE
type: Class
subclass of: hemorrhage AE
definition: a hemorrhage AE that has an outcome of ecchymosis
has_MedDRA_id: 10014080
comment: an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis
see also: HPO: HP_0000978
see also: MP: MP_0009276
see also: SIDER: C0013491

serious adverse event
type: Class
subclass of: adverse event
definition: serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death.
definition editor: YH, MC
alternative term: serious adverse event
alternative term: severe adverse event
definition source: WEB: http://en.wikipedia.org/wiki/Serious_adverse_event
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA

death AE
type: Class
subclass of: serious adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G5
definition: a serious adverse event that has an outcome of death.
definition editor: YH
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
has_MedDRA_id: 10011906
has_MedDRA_id: 10011914
has_exact_synonym: death
see also: CTCAE: E11080
see also: HPO: HP_0001645
see also: NCIt: C28554
see also: SIDER: C1306577

life-threating AE
type: Class
subclass of: serious adverse event
definition: a serious AE that is suspected to put the patient at substantial risk of dying at the time of the adverse event, or that the use or continued use of the device or other medical product might have resulted in the death of the patient.
definition editor: DJ, SS, YH, JX
alternative term: apparent life threatening event AE
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
has_MedDRA_id: 10065044

hospitalization AE
type: Class
subclass of: serious adverse event
definition: a serious adverse event that leads to hospitalization. Such an adverse event resulted in an admission to the hospital or prolongation of hospitalization.
definition editor: YH, JX
alternative term: adverse event leading to hospitalization
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm

disability or permanent damage AE
type: Class
subclass of: serious adverse event
definition: a serious adverse event that leads to disability or permanent damage. Such an adverse event results in a substantial disruption of a person's ability to conduct normal life functions, i.e., the adverse event resulted in a significant, persistent or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities and/or quality of life.
definition editor: YH, JX
alternative term: adverse event leading to disability
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm

congenital anomaly or birth defect AE
type: Class
subclass of: serious adverse event
definition: a serious adverse event that resulted in congenital anomaly and bith defect, leading to suspicions that an exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child.
definition editor: YH, JX
alternative term: adverse event leading to congenital anomaly
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.thefreedictionary.com/birth+defect
has_MedDRA_id: 10010356

adverse event that requires intervention to prevent permanent impairment or damage
type: Class
subclass of: serious adverse event
definition: a serious adverse event which is an adverse event that requires intervention to prevent permanent impairment or damage leads to suspicions that the use of a medical product may result in a condition which requires a medical or surgical intervention to preclude permanent impairment or damage to a patient.
definition editor: YH, JX
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm

non-serious adverse event
type: Class
subclass of: adverse event
definition: an adverse event that is considered not serious.
definition editor: YH, MC
definition source: WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA

low-grade fever AE
type: Class
subclass of: fever AE
definition: low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C).
definition editor: YH
definition source: WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521
comment: The low-grade level of fever is beneficial. With most microbes/"bugs" that a child will be exposed to, this fever will assist the body in repelling the invader.

moderate-grade fever AE
type: Class
subclass of: fever AE
definition: moderate-grade fever AE is a fever adverse event with a temperature typically between 102.2° F and 104.5° F (39° C and 40° C).
definition editor: YH
definition source: WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521
comment: This moderate-grade fever temperature is still considered beneficial. If a child's body has reached this temperature, it's what's needed to kill whatever bacteria or virus their body is attempting to fight.

high-grade fever AE
type: Class
subclass of: fever AE
definition: high-grade fever AE is a fever adverse event with a fever temperature greater than 104.5° F (40° C).
definition editor: YH
definition source: WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521
comment: This fever may cause the child some discomfort and result in crankiness. Generally indicative of a bacterial infection, this fever means that the body is fighting something more serious than the common cold.

hyperpyrexia AE
type: Class
subclass of: fever AE
definition: hyperpyrexia AE is a fever adverse event that has an outcome of an excessive and unusual elevation of set body temperature greater than or equal to 41 °C. It is an extremely high fever. Such a high temperature is considered a medical emergency as it may indicate a serious underlying condition such as sepsis.
definition editor: YH
alternative term: extreme pyrexia AE
definition source: Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828.
definition source: WEB: http://en.wikipedia.org/wiki/Hyperpyrexia
has_MedDRA_id: 10020741
see also: HPO: HP_0001945
see also: SIDER: C0392676

musculoskeletal pain AE
type: Class
subclass of: pain AE
definition: a pain AE that has an outcome of musculoskeletal pain
definition editor: SS, YH
definition source: WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain
has_MedDRA_id: 10028391
comment: Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones.
see also: HPO: HP_0003326
see also: SIDER: C0026858

injection-site erythema AE
type: Class
subclass of: injection-site AE
subclass of: erythema AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Erythema
definition source: WEB: http://medical-dictionary.thefreedictionary.com/erythema
has_MedDRA_id: 10022061

erythema AE
type: Class
subclass of: skin AE
definition: Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin.
definition editor: SS, YH
alternative term: reddish skin
definition source: WEB: http://en.wikipedia.org/wiki/Erythema
has_MedDRA_id: 10015150
see also: HPO: HP_0010783
see also: SIDER: C0041834

sinus headache AE
type: Class
subclass of: headache AE
definition: a headache AE that has an outcome of sinus headache
definition editor: YH, SS
definition source: WEB: http://american-rhinologic.org/patientinfo.headache.phtml
comment: sinus headache is a headache located over the sinuses, (forehead, corners of the eye, and cheek areas). On occasion, the pain will be felt behind the eyes, in the back of the neck, or may extend into the upper teeth.
see also: HPO: HP_0002315
see also: SIDER: C0037195

pneumonia AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002048
definition: an inflammation AE that occurs in the lung. It is often characterized as including inflammation of the parenchyma of the lung (that is, the alveoli) and abnormal alveolar filling with fluid (consolidation and exudation).
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Pneumonia
has_MedDRA_id: 10035664
see also: HPO: HP_0002090
see also: SIDER: C0032285

lobar pneumonia AE
type: Class
subclass of: pneumonia AE
definition: lobar pneumonia is pneumonia AE that affects a large and continuous area of the lobe of a lung
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Lobar_pneumonia
has_MedDRA_id: 10024738
see also: HPO: HP_0002090
see also: SIDER: C0032300

axillary pain AE
type: Class
subclass of: pain AE
definition: axillary pain AE is a pain AE that occurs in the underarm (the area on the human body directly under the join where the arm connects to the shoulder)
definition editor: SS, YH

hematoma AE
type: Class
subclass of: cardiovascular AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise.
editor note: YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma".
definition editor: SS, YH
alternative term: bruise AE
alternative term: bruising AE
alternative term: ecchymoses AE
alternative term: haematoma AE
definition source: WEB: http://en.wikipedia.org/wiki/Hematoma
has_MedDRA_id: 10006504
has_MedDRA_id: 10018852
has_MedDRA_id: 10019428
see also: CTCAE: E13775 (hematoma); CTCAE: E11666 (brruising)
see also: HPO: HP_0001892
see also: NCIt: C37921 (Bruising); NCIt: C50579 (Hematoma)
see also: SIDER: C0018944

reproductive system AE
type: Class
subclass of: adverse event
definition: reproductive system AE is an AE that occurs in the reproductive system.
definition editor: YH, SS

antinuclear antibody negative AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE which has an outcome of antinuclear antibody negative
definition editor: SS, YH

CSF white blood cell count negative AE
type: Class
subclass of: CSF test result abnormal AE
definition: a CSF test result abnormal AE that has an outcome of CSF white blood cell count negative
definition editor: SS, YH, EB
has_MedDRA_id: 10061099

influenza serology positive AE
type: Class
subclass of: microbiology and serology investigation result abnormal AE
definition: a microbiology and serology investigation result abnormal AE that has an outcome of positive influenza serology test result
definition editor: SS, YH, EB
has_MedDRA_id: 10060078

VIIth nerve paralysis AE
type: Class
subclass of: paralysis AE
definition editor: YH
definition editor: a paralysis AE that has an outcome of VIIth nerve paralysis
has_MedDRA_id: 10050040
see also: HPO: HP_0006824
see also: SIDER: C0919980

aspartate aminotransferase level increased AE
type: Class
subclass of: aspartate aminotransferase level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: an aspartate aminotransferase level abnormal AE that has an outcome of an increased amount of AST, an enzyme normally present in body tissues especially of the heart and liver
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/aspartate+aminotransferase
has_MedDRA_id: 10003481
see also: CTCAE: E12087
see also: NCIt: C26947

accidental overdose in medical intervention
type: Class
subclass of: incorrect dose administration
definition: an incorrect dose administration that accidentally uses overdose
definition editor: SS, YH
has_MedDRA_id: 10000381

acute disseminated encephalomyelitis AE
type: Class
subclass of: autoimmune disorder AE
definition: an immune system disorder AE which has an outcome of acute disseminated encephalomyelitis
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Acute_disseminated_encephalomyelitis
has_MedDRA_id: 10000709
comment: Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually occurs following a viral infection but may appear following vaccination, bacterial or parasitic infection, or even appear spontaneously. As it involves autoimmune demyelination, it is similar to multiple sclerosis, and is considered part of the Multiple sclerosis borderline diseases.

atrial fibrillation AE
type: Class
subclass of: arrhythmia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an arrhythmia AE that involves the two upper chambers (atria) of the heart
definition editor: SS, YH
alternative term: AF
definition source: WEB: http://en.wikipedia.org/wiki/Atrial_fibrillation
definition source: WEB: http://medical-dictionary.thefreedictionary.com/atrial+fibrillation
has_MedDRA_id: 10003658
comment: Atrial fibrillation (AF or A-fib) is the most common cardiac arrhythmia (abnormal heart rhythm), and involves the two upper chambers (atria) of the heart. Its name comes from the fibrillating (i.e., quivering) of the heart muscles of the atria, instead of a coordinated contraction.
see also: CTCAE: E10081
see also: HPO: HP_0005110
see also: NCIt: C50466
see also: SIDER: C0004238

arrhythmia AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE which has an outcome of abnormal heart rhythm
definition editor: SS, YH
alternative term: abnormal heartbeat AE
alternative term: cardiac arrhythmia AE
definition source: WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/arr/
has_MedDRA_id: 10003119
see also: HPO: HP_0011675
see also: MP: MP_0004085
see also: SIDER: C0003811

mitral valve stenosis AE
type: Class
subclass of: cardiac valve disease AE
definition: a cardiac valve disease AE that is characterized by a condition of the heart in which one of the valve openings has become narrow and restricts the flow of blood from the upper left chamber (left atrium) to the lower left chamber (left ventricle).
definition editor: SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/mitral+valve+stenosis
has_MedDRA_id: 10027733

blood creatinine level decreased AE
type: Class
subclass of: blood creatinine level abnormal AE
definition: a blood creatinine level abnormal AE that has an outcome of decreased blood creatine
definition editor: SS, YH, EB
has_MedDRA_id: 10005482

carbon dioxide decreased AE
type: Class
subclass of: carbon dioxide abnormal AE
definition editor: SS, YH, EB
has_MedDRA_id: 10007223
backward compatible with: a carbon dioxide abnormal AE that has an outcome of a decreased level of carbon dioxide in the blood

contraindication to vaccination
type: Class
subclass of: contraindication
definition: A contraindication that is specifically for vaccination.
definition editor: SS, YH

croup infection AE
type: Class
subclass of: infection AE
definition: an infection adverse event that has an outcome of croup infection
definition editor: SS, YH
definition source: WEB: http://www.medicinenet.com/croup/article.htm
comment: Croup is an infectious illness of the respiratory system involving the vocal cords (larynx), the windpipe (trachea), and the upper airways of the lungs (bronchial tubes). The majority of a child's symptoms reflect involvement of the larynx. Croup is usually a viral infection and maybe caused by many different viruses, including those responsible for the common cold and influenza. Rarely, croup is caused by a bacterial infection.

aspiration AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has an outcome of the drawing of a foreign substance into the respiratory tract during inhalation
definition editor: DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/aspiration
has_MedDRA_id: 10003504
see also: HPO: HP_0002835
see also: SIDER: C0700198

aspiration pleural cavity AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of the removal of gas or fluid from the pleural cavity of the lungs
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/aspiration
has_MedDRA_id: 10003522

excoriation AE
type: Class
subclass of: skin AE
definition: a skin adverse event which has an outcome of excoriation AE is an injury to a surface of the body caused by trauma, such as scratching, abrasion, or a chemical or thermal burn.
definition editor: SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/excoriation
has_MedDRA_id: 10049796

facial pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of facial pain
definition editor: SS, YH
definition source: WEB: http://www.bettermedicine.com/article/facial-pain
has_MedDRA_id: 10016059
comment: facial pain is a pain in facial area (eyes, eyebrows, forehead, nose, cheeks, mouth, teeth and chin). Facial pain may include injuries to the nerves or bones that coordinate many of your face’s actions.
see also: CTCAE: E11094
see also: HPO: HP_0100661
see also: NCIt: C79594
see also: SIDER: C0015468

full blood count abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that has an outcome of abnormal full blood count
definition editor: SS, YH, EB
has_MedDRA_id: 10017412
has_MedDRA_id: 10064198

obsolete: hyporeflexia AE
type: Class
subclass of: ObsoleteClass
definition: a reflexes decreased AE that has an outcome of hyporeflexia
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hyporeflexia
has_MedDRA_id: 10021089
comment: Obsoleted because of duplication
comment: hyporeflexia is the condition of below normal or absent reflexes. Hyporeflexia is generally associated with a lower motor neuron deficit (at the alpha motor neurons from the spinal cord to muscle).
see also: HPO: HP_0009072
see also: SIDER: C0151888

astrocytoma AE
type: Class
subclass of: tumor AE
definition: a tumor AE that is characterized by cancer in the brain
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/astrocytoma
has_MedDRA_id: 10003571
see also: HPO: HP_0009592
see also: SIDER: C0004114

incorrect dose administration
type: Class
subclass of: errored medication
definition: a medical intervention that uses incorrect dose
definition editor: SS, YH
has_MedDRA_id: 10064355

atelectasis AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung disorder AE that has an outcome of collapse in part of or all of a lung
definition editor: DJ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001130/
has_MedDRA_id: 10003598
see also: HPO: HP_0001642
see also: SIDER: C0004144

influenza virus test positive AE
type: Class
subclass of: influenza serology positive AE
definition: an influenza serology positive AE that has an outcome of positive result in an influenza virus test
definition editor: SS, YH, EB
has_MedDRA_id: 10070717

joint range of motion decreased AE
type: Class
subclass of: mobility decreased AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: joint range of motion decreased AE is a mobility decreased AE that results in limited or decreased range of joint motion
definition editor: SS, YH, MW
has_MedDRA_id: 10048706
see also: CTCAE: E12435
see also: NCIt: C78403

laryngospasm AE
type: Class
subclass of: muscle spasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a muscle spasm AE which has an outcome of laryngospasm, which is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. The condition typically lasts less than 60 seconds, and causes a partial blocking of breathing in, while breathing out remains easier. It may be triggered when the vocal cords or the area of the trachea below the cords detects the entry of water, mucus, blood, or other substance. It is characterized by stridor and or retractions.
definition editor: SS, YH, MW
definition source: WEB: http://en.wikipedia.org/wiki/Laryngospasm
has_MedDRA_id: 10023891
see also: HPO: HP_0006511
see also: SIDER: C0023066

lymphocyte percentage decreased AE
type: Class
subclass of: lymphocyte percentage abnormal AE
definition: a lymphocyte percentage abnormal AE that has an outcome of decreased lymphocyte percentage
definition editor: SS, YH, EB
has_MedDRA_id: 10052231

monocyte percentage increased AE
type: Class
subclass of: monocyte percentage abnormal AE
definition: a monocyte percentage abnormal AE that has an outcome of increased monocyte percentage
definition editor: SS, YH, EB
has_MedDRA_id: 10052230

nuclear magnetic resonance imaging brain abnormal AE
type: Class
subclass of: nuclear magnetic resonance imaging result abnormal AE
definition: a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the brain
definition editor: SS, YH
has_MedDRA_id: 10029818

periorbital edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000970
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: periorbial edema AE is an edema AE that has an outcome of swelling around the eye.
editor note: MedDRA: 10034545 is for "periorbital edema"; MedDRA: 10054541 is for "periorbital oedema"
definition editor: SS, YH
alternative term: periorbital oedema AE
alternative term: periorbital puffiness
definition source: WEB: http://en.wikipedia.org/wiki/Periorbital_puffiness
comment: Periorbital puffiness, also known as "puffy eyes" or swelling around the eyes, refers to the appearance of swelling in the tissues around the eyes, called the orbits.
see also: CTCAE: E13676
see also: NCIt: C78530
see also: UMLS CUI: C0151205

pregnancy test positive
type: Class
subclass of: PATO_0002062
definition: a physical quality of a process that shows a positive result of a pregnancy test.
definition editor: SS, YH
has_MedDRA_id: 10036556
has_MedDRA_id: 10036575

hypermagnesemia AE
type: Class
subclass of: blood magnesium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood magnesium decreased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood magnesium abnormal AE that has an outcome of an abnormally high concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors.
definition editor: YH, MW
definition source: WEB: http://emedicine.medscape.com/article/246489-overview
has_MedDRA_id: 10020670
see also: CTCAE: E12288
see also: NCIt: C37969
see also: UMLS CUI: C0151714

sensation of foreign body AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of a sensation feeling of foreign body
definition editor: SS, YH
has_MedDRA_id: 10061549

sensation of heaviness AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of a sensation feeling of heaviness
definition editor: SS, YH
alternative term: feeling heavy AE

sensory loss AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of a loss of sensation
definition editor: SS, YH
has_MedDRA_id: 10040030
see also: HPO: HP_0003474
see also: SIDER: C0278134

skin exfoliation AE
type: Class
subclass of: skin AE
definition: a skin adverse event that has an outcome of skin exfoliation
definition editor: SS, YH
has_MedDRA_id: 10040844
see also: HPO: HP_0007549
see also: SIDER: C0237849

stomach discomfort AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000945
definition: a digestive system AE which has an outcome of stomach discomfort
definition editor: SS, YH
alternative term: stomach upset AE
Chinese translation: 胃部不适
has_MedDRA_id: 10042124

autoantibody positive AE
type: Class
subclass of: immunology and allergy investigation result abnormal AE
definition: an immunology and allergy investigation result abnormal AE that has an outcome of autoantibodies present
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/autoantibody
has_MedDRA_id: 10060973

stridor AE
type: Class
subclass of: wheezing AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a wheezing AE which has an outcome of stridor, a high pitched wheezing sound resulting from turbulent air flow in the upper airway. It is primarily inspiratory. It can be indicative of serious airway obstruction from severe conditions such as epiglottitis, a foreign body lodged in the airway, or a laryngeal tumor.
definition editor: SS, YH, MW
definition source: WEB: http://en.wikipedia.org/wiki/Stridor
has_MedDRA_id: 10042241
see also: HPO: HP_0010307
see also: SIDER: C0038450

skin ulceration AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a skin AE that shows a result of skin ulcer, i.e., a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat.
definition editor: SS, YH, MW
alternative term: skin ulcer AE
definition source: WEB: http://en.wikipedia.org/wiki/Ulcer_%28dermatology%29
has_MedDRA_id: 10040943
has_MedDRA_id: 10040947
see also: CTCAE: E13730
see also: HPO: HP_0200042
see also: NCIt: C54247
see also: SIDER: C0037299

underdose adminstration in medical intervention
type: Class
subclass of: incorrect dose administration
definition: an incorrect dose administration that uses underdose
definition editor: SS, YH

upper respiratory tract congestion AE
type: Class
subclass of: respiratory tract congestion AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001557
definition: a respiratory tract congestion AE which has an outcome of upper respiratory tract congestion
definition editor: SS, YH

urine analysis result abnormal AE
type: Class
subclass of: urinary system investigation result abnormal AE
definition: a urinary system investigation result abnormal AE that has an outcome of a urine analysis abnormality
definition editor: SS, YH, EB
has_MedDRA_id: 10062226

urine ketone body present AE
type: Class
subclass of: urine analysis result abnormal AE
definition: a urine analysis result abnomal AE that shows ketone body present in urine
definition editor: SS, YH, EB, QL
has_MedDRA_id: 10057597

autoimmune hepatitis AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE that has an outcome of inflammation of the liver that occurs when immune cells mistake the liver's normal cells for harmful invaders and attack them
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001291/
has_MedDRA_id: 10003827
see also: HPO: HP_0004787
see also: SIDER: C0241910

vaginal hemorrhage AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000996
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has an outcome of vaginal hemorrhage
editor note: MedDRA: 10046910 is for "vaginal haemorrhage"; MedDRA: 10046912 is for "vaginal hemorrhage"
definition editor: SS, YH, MW
alternative term: vaginal haemorrhage AE
definition source: WEB: http://www.brooksidepress.org/Products/Military_OBGYN/Textbook/AbnormalBleeding/Bleeding.htm
comment: vaginal hemorrhage is irregular/heavy bleeding from the vagina. Vaginal hemorrhage is more often associated with pregnancy complications such as miscarriage or placental abruption, but certainly can occur in the absence of pregnancy.
see also: CTCAE: E13264
see also: NCIt: C26945

vasodilatation AE
type: Class
subclass of: cardiovascular AE
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Vasodilation
comment: a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins.
see also: HPO: HP_0004927
see also: SIDER: C0595862

bacteremia AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE that has an outcome of bacteria in the blood
definition editor: DJ, SS, YH
alternative term: bacteraemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bacteremia
has_MedDRA_id: 10003997

bacterial sepsis AE
type: Class
subclass of: sepsis AE
definition: a sepsis AE caused by bacterial infection in the bloodstream or body tissues
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/sepsis
has_MedDRA_id: 10053840

basal cell carcinoma AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a slow-growing nonmelanoma skin cancer
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001827/
has_MedDRA_id: 10004146
see also: HPO: HP_0002671
see also: SIDER: C0007117

basophil count increased AE
type: Class
subclass of: basophil count abnormal AE
definition: a basophil count abnormal AE that is characterized by increase in the number of basophils in the body
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/basophil+granulocyte
has_MedDRA_id: 10004169

behcet's syndrome AE
type: Class
subclass of: ulcer AE
definition: an ulcer AE that is characterized by ulcers in the mouth that may decrease ocular functionality
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/behcet's+disease
has_MedDRA_id: 10004213

benign congenital hypotonia AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal system AE that has an outcome of low muscle tone
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypotonia
has_MedDRA_id: 10051900

benign hydatidiform mole AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that has an outcome of a non-fertilized egg that implants itself in the uterus and turns a normal pregnancy into an abnormal one
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hydatidiform+mole
has_MedDRA_id: 10004272

benign ovarian tumor AE
type: Class
subclass of: benign tumor AE
definition: a benign tumor AE that has an outcome of a benign tumor in their ovaries
definition editor: DJ, SS, YH
alternative term: benign ovarian tumour AE
has_MedDRA_id: 10004433

bile duct obstruction AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of a blockage in the tubes that carry bile from the liber to the gallbladder and small intestine
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000263.htm
has_MedDRA_id: 10056375

biliary dilatation AE
type: Class
subclass of: hepatobiliary or pancreatic AE
definition: a liver/biliary system AE that has an outcome of dilating or stretching of the bile duct
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21843715
has_MedDRA_id: 10057202

binge eating AE
type: Class
subclass of: eating disorder AE
definition: an eating disorder that is characterized by episodes of uncontrollable eating.
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/binge+eating
has_MedDRA_id: 10004716

binocular eye movement disorder AE
type: Class
subclass of: eye AE
definition: an eye disorder AE that has an outcome of binocular eye movement disorder where control and alignment of eyes are compromised
definition editor: DJ, SS, YH
definition source: WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/23201436 Secondary Source: http://brain.oxfordjournals.org/content/119/6/1933.full.pdf
has_MedDRA_id: 10061010

bladder cancer AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0001255
definition: a digestive system AE that has an outcome of cancer that starts in the bladder, the body part that holds and releases urine in the center of the lower belly area
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001517/
has_MedDRA_id: 10005003
see also: HPO: HP_0009725
see also: SIDER: C0005684

blast cell count increased AE
type: Class
subclass of: blast cell count abnormal AE
definition: a blast cell count abnormal AE that has an outcome of an increased amount of immature precursors of either lymphocytes or granulocytes that do not normally appear in peripheral blood. May indicate acute leukemia
definition editor: DJ, SS, YH
definition source: WEB: http://meds.queensu.ca/medicine/deptmed/hemonc/anemia/blast.htm
has_MedDRA_id: 10062274

blast cell crisis AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of a sudden, severe change in the course of chronic granulocytic leukemia with an increase in the proportion of myeloblasts
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/blast+crisis
has_MedDRA_id: 10053747

blast cells present AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of myeloblasts or myeloid blasts. Presence of these abnormal blasts prevent production of adequate platelets, red blood cells and white blood cells, can be associated with leukemia
definition editor: DJ, SS, YH
definition source: WEB: http://lymphoma.about.com/od/glossary/ss/Blast-Cells.htm
has_MedDRA_id: 10057107

blast crisis in myelogenous leukemia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of the last stage of chronic myelogenous leukemia characterized by rapid progression and short survival with an increase of myeloblasts or lymphoblasts in the blood or bone marrow
definition editor: DJ, SS, YH
alternative term: blast crisis in myelogenous leukaemia AE
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/blast+crisis , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23171293
has_MedDRA_id: 10050282

blepharitis AE
type: Class
subclass of: eye inflammation AE
definition: an eye inflammation AE that has an outcome of swelling in the eyelids, usually where eyelash follicles are located
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002586/
has_MedDRA_id: 10005148
see also: HPO: HP_0000498
see also: SIDER: C0005741

blood albumin level decreased AE
type: Class
subclass of: blood albumin level abnormal AE
definition: a blood albumin level abnormal AE with an outcome of a decrease in the amount of albumin, a protein made by the liver
definition editor: DJ, SS, YH, EB
alternative term: hypoalbuminemia AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003480.htm
has_MedDRA_id: 10005287

blood alkaline phosphatase level abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a liver related investigation result abnormal AE that has an outcome of an abnormal level of alkaline phosphatase in the blood
definition editor: DJ, SS, YH, EB
has_MedDRA_id: 10059571

blood alkaline phosphatase decreased AE
type: Class
subclass of: blood alkaline phosphatase level abnormal AE
definition: a blood alkaline phosphatase abnormal AE that has an outcome of a decreased level of alkaline phosphatase in the blood
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase
has_MedDRA_id: 10059569

blood alkaline phosphatase increased AE
type: Class
subclass of: blood alkaline phosphatase level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a blood alkaline phosphatase abnormal AE that has an outcome of elevated levels of alkaline phosphatase, an enzyme responsible for removing phosphate groups. a liver/biliary system AE that has an outcome of an increased amount of ALP, an isoenzyme that removes phosphate groups commonly found in the bile ducts but also found in the bone
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase
has_MedDRA_id: 10001675
has_MedDRA_id: 10059570
see also: CTCAE: E12082
see also: HPO: HP_0003155
see also: NCIt: C35607
see also: SIDER: C0852911

chronic inflammatory demyelinating neuropathy AE
type: Class
subclass of: distal neuropathy AE
definition: a distal neuropathy AE which shows a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. It is caused by the loss of myelin sheath of the peripheral nerves.
definition editor: AG, YH
alternative term: CIDP
alternative term: Chronic Inflammatory Demyelinating Polyneuropathy
definition source: WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm

blood amylase level increased AE
type: Class
subclass of: blood amylase level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a blood amylase level abnormal AE that has an outcome of an increased amount of amylase, an enzyme that helps digest carbohydrates; may indicate disease or inflammation of the pancreas
definition editor: DJ, SS, YH, EB
alternative term: serum amylase increased AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003464.htm
has_MedDRA_id: 10005328
has_MedDRA_id: 10040139
see also: CTCAE: E12212
see also: NCIt: C78608

blood bilirubin level abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a liver related investigation result abnormal AE that has an outcome of an abnormal amount of bilirubin in the blood
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bilirubin
has_MedDRA_id: 10058477

blood bilirubin level increased AE
type: Class
subclass of: blood bilirubin level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a blood bilirubin level abnormal AE with an outcome of a increased amount of bilirubin, or a yellow breakdown product (broken down hemoglobin) of normal heme catabolism, in the blood
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bilirubin
has_MedDRA_id: 10005364
see also: CTCAE: E12096
see also: NCIt: C27088

blood calcium decreased
type: Class
subclass of: PATO_0001018
definition: a physical quality that has a decreased amount of calcium in the bloodstream
definition editor: DJ, SS, YH
has_MedDRA_id: 10005395

blood chloride decreased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an decreased level of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease
definition editor: DJ, SS, YH
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=9940
has_MedDRA_id: 10005419
see also: HPO: HP_0003113
see also: SIDER: C0595902

blood cholesterol increased AE
type: Class
subclass of: blood cholesterol abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a blood cholesterol abnormal AE with the result of an increase in cholesterol level in the blood
definition editor: DJ, SS, YH, EB
has_MedDRA_id: 10005425
see also: CTCAE: E12127
see also: HPO: HP_0003124
see also: NCIt: C37967
see also: SIDER: C0595930

blood creatine phosphokinase level abnormal AE
type: Class
subclass of: enzyme investigation result abnormal AE
definition: an enzyme investigation result abnormal AE that has an outcome of abnormal levels of creatine phosphokinase in the blood
definition editor: DJ, SS, YH, EB
has_MedDRA_id: 10005468

blood creatinine level increased AE
type: Class
subclass of: blood creatinine level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a blood creatinine level abnormal AE that has an outcome of an increased level of creatinine in the blood (due to lack of kidney activity)
definition editor: DJ, SS, YH, EB
alternative term: creatinine increased AE
alternative term: serum creatinine increased
definition source: WEB: http://medical-dictionary.thefreedictionary.com/creatinine
has_MedDRA_id: 10005483
has_MedDRA_id: 10011368
see also: CTCAE: E12137
see also: NCIt: C78249

blood culture positive AE
type: Class
subclass of: infection AE
definition: an infection adverse event that has an outcome of bacteria or yeasts in the blood
definition editor: DJ, SS, YH
definition source: WEB: http://labtestsonline.org/understanding/analytes/blood-culture/tab/test
has_MedDRA_id: 10005488

blood disorder AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000178
definition: a hematopoietic system AE that has an outcome of disease in the blood, a living tissue made up of plasma and red blood cells, white blood cells and platelets. Blood disorders affect one or more parts of the blood and prevent the blood from doing this job.
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/blooddisorders.html
has_MedDRA_id: 10061590

blood folate level decreased AE
type: Class
subclass of: abdomen crushing AE
definition: a blood folate abnormal AE that has an outcome of a decreased level of folate in the blood
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/folate
has_MedDRA_id: 10005527

blood glucose level decreased AE
type: Class
subclass of: blood glucose level abnormal AE
definition: a blood glucose level abnormal AE that has an outcome of a decrease of glucose levels in blood
definition editor: DJ, SS, YH, EB
has_MedDRA_id: 10005555

blood glucose level increased AE
type: Class
subclass of: blood glucose level abnormal AE
definition: a blood glucose level abnormal AE that has an outcome of an increased glucose level in blood
definition editor: DJ, SS, YH, EB
has_MedDRA_id: 10005557

blood homocysteine level increased AE
type: Class
subclass of: blood homocysteine level abnormal AE
definition: a blood homocysteine level abnormal AE that has an outcome of an increased levels of homocysteine in the blood
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/homocysteine
has_MedDRA_id: 10049733

blood immunoglobulin A level increased AE
type: Class
subclass of: OAE_0004254
definition: an immunology and allergy investigation result abnormal AE that results in an increased immunoglobulin a level in the blood
definition editor: DJ, SS, YH, EB
alternative term: IgA level increased
definition source: WEB: http://medical-dictionary.thefreedictionary.com/immunoglobulin+A
has_MedDRA_id: 10005586

blood lactate dehydrogenase level increased AE
type: Class
subclass of: blood lactate dehydrogenase level abnormal AE
definition: a blood lactate dehydrogenase level abnormal AE that has an outcome of an increased amount of LDH, an enzyme that could indicate tissue damage
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm
has_MedDRA_id: 10005630

blood magnesium decreased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an decreased level of magnesium, a mineral involved in nerve signaling and bone health. Deficiency can cause spasms, and muscular cramps.
definition editor: DJ, SS, YH
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=4243
has_MedDRA_id: 10005654
see also: HPO: HP_0002917
see also: SIDER: C0853750

blood parathyroid hormone decreased AE
type: Class
subclass of: blood parathyroid hormone level abnormal AE
definition: a blood parathyroid hormone level abnormal AE that has an outcome of a decrease in the level of parathyroid hormone in the blood
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/parathyroid+hormone
has_MedDRA_id: 10005702

blood phosphorus decreased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an decreased level of decreased phosphorus in the blood
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003478.htm
has_MedDRA_id: 10049471
see also: HPO: HP_0002148
see also: SIDER: C0877517

blood potassium decreased
type: Class
subclass of: PATO_0001018
definition: a physical quality where the blood potassium level is decreased.
definition editor: DJ, SS, YH, LW, MW
Chinese translation: 血钾下降
has_MedDRA_id: 10005724
see also: HPO: HP_0002900

blood pressure diastolic decreased AE
type: Class
subclass of: hypotension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: a hypotension AE that has an outcome of a decrease in the amount of pressure in the arteries when the heart is at rest between beats
definition editor: DJ, SS, YH
definition source: WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes
has_MedDRA_id: 10005737

blood pressure immeasurable AE
type: Class
subclass of: hypotension AE
definition: a hypotension AE that has an outcome of immeasurable blood pressure
definition editor: DJ, SS, YH
has_MedDRA_id: 10005748

blood sodium decreased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an decreased level of sodium concentration in the blood
definition editor: DJ, SS, YH, MW
has_MedDRA_id: 10005802

blood thromboplastin level increased AE
type: Class
subclass of: blood thromboplastin level abnormal AE
definition: a blood thromboplastin level abnormal AE that has an outcome of an increase in the level of thromboplastin in the blood
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/thromboplastin
has_MedDRA_id: 10005827

blood urea level decreased AE
type: Class
subclass of: blood urea level abnormal AE
definition: a blood urea level abnormal AE with an outcome of a decreased amount of urea nitrogen in the blood, below 7 to 21 mg of urea per 100 ml
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/blood+urea+nitrogen
has_MedDRA_id: 10005850

blood urea level increased AE
type: Class
subclass of: blood urea level abnormal AE
definition: a blood urea level abnormal AE that results in an increase in amount of urea in blood
definition editor: DJ, SS, YH, EB
has_MedDRA_id: 10005851

blood uric acid level increased AE
type: Class
subclass of: blood uric acid level abnormal AE
definition: a blood uric acid level abnormal AE that has an outcome of an increase in uric acid in the blood; excess purines may accumulate in tissues and form crystals
definition editor: DJ, SS, YH, EB
definition source: WEB: http://chemocare.com/chemotherapy/side-effects/hyperuricemia-high-uric-acid.aspx
has_MedDRA_id: 10005861

bone cyst AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of a cyst that forms on the bone
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bone+cyst
has_MedDRA_id: 10005952

bone debridement AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of surgery to clean and flush out the infected bone
definition editor: DJ, SS, YH
definition source: WEB: http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Osteomyelitis
has_MedDRA_id: 10057612

bone lesion AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of an anomlay in the growth or structure of a bone
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/20972590
has_MedDRA_id: 10061728

bone marrow depression AE
type: Class
subclass of: bone marrow disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a bone marrow disorder AE that has an outcome of an abnormal condition in which the bone marrow is unable to produce normal amounts of red blood cells, white blood cells and platelets
definition editor: DJ, SS, YH, MW
alternative term: bone marrrow hypocellular
alternative term: hypocellular bone marrow
definition source: WEB: http://en.diagnosispro.com/differential_diagnosis-for/bx-bone-marrow-biopsy-hypocellular/29777-154.html
definition source: WEB: http://www.drugs.com/condition/bone-marrow-depression-low-blood-counts.html
has_MedDRA_id: 10005986
has_MedDRA_id: 10048580
comment: Bone marrow produces three types of blood cells; red blood cells, white blood cells and platelets. Bone marrow depression is characterized by an inability or reduced ability of the bone marrow to produce these cells. A low blood count can involve just one or all three types of blood cells.
see also: CTCAE: E10022
see also: HPO: HP_0012145
see also: NCIt: C35167
see also: SIDER: C0151773
see also: UMLS: C0151773

bone marrow disorder AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002371
definition: a hematopoietic system AE that has an outcome of disease in the bone marrow, the spongy tissue inside of some bones that contain stem cells that can develop into red blood cells, white blood cells or platelets
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html
has_MedDRA_id: 10061729

bone marrow failure AE
type: Class
subclass of: bone marrow disorder AE
definition: a bone marrow disorder AE that has an outcome of an insufficient amount of red blood cells, white blood cells or platelets, associated with fanconii anemia, dyskeratosis congenita, and aplastic anemia
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23271412
has_MedDRA_id: 10065553

bone marrow reticulin fibrosis AE
type: Class
subclass of: bone marrow disorder AE
definition: a bone marrow disorder AE that has an outcome of an excess formation of connective tissue in the bone marrow
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22246040
has_MedDRA_id: 10069678

bone marrow toxicity AE
type: Class
subclass of: bone marrow disorder AE
definition: a bone marrow disorder AE that has an outcome of the decrease in cells responsible for providing immunity, carrying oxygen and blood clotting
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/12806941
has_MedDRA_id: 10051779
see also: HPO: HP_0005561
see also: SIDER: C0948168

bone marrow transplant AE
type: Class
subclass of: bone marrow disorder AE
definition: a bone marrow disorder AE that has an outcome of the replacement of damaged bone marrow with healthy bone marrow stem cells
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003009.htm
has_MedDRA_id: 10061730

bone swelling AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001474
definition: a swelling AE that results in swelling around a bone
definition editor: DJ, SS, YH
has_MedDRA_id: 10053631

bowen's disease AE
type: Class
subclass of: skin AE
definition: a skin adverse event that has an outcome of an early stage of squamous cell carcinoma
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bowen's+disease
has_MedDRA_id: 10006059

bradycardia neonatal AE
type: Class
subclass of: decreased heart rate AE
definition: a bradycardia AE that results in a decreased heart rate in a neonate
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/10822186
has_MedDRA_id: 10056471
see also: HPO: HP_0001662
see also: SIDER: C1112488

brain edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
definition: an edema AE that has an outcome of edema or swelling of the extravascular compartment from uptake of water in the gray and white matter
definition editor: DJ, SS, YH
alternative term: brain oedema AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cerebral+edema
has_MedDRA_id: 10048962
see also: HPO: HP_0002181
see also: SIDER: C1527311

breast cancer AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000310
definition: a tumor AE that has an outcome of cancer in the breast
definition editor: DJ, SS, YH
has_MedDRA_id: 10006187
see also: HPO: HP_0003002
see also: SIDER: C0006142

breast cancer metastatic AE
type: Class
subclass of: breast cancer AE
definition: a breast cancer AE that has an outcome of cancerous cells spreading to the breast
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001911/
has_MedDRA_id: 10055113

breast cancer stage iii AE
type: Class
subclass of: breast cancer AE
definition: a breast cancer AE that has an outcome of breast cancer at the stage III level
definition editor: DJ, SS, YH
has_MedDRA_id: 10006201

breast infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000310
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an infection AE that results in the breast becoming infected
definition editor: DJ, SS, YH
has_MedDRA_id: 10006259
see also: CTCAE: E11318
see also: HPO: HP_0002726
see also: NCIt: C53662
see also: SIDER: C0392317

breast pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that results in pain in the breast
definition editor: DJ, SS, YH, MW
has_MedDRA_id: 10006298
see also: HPO: HP_0000769
see also: SIDER: C0024902

breast tenderness AE
type: Class
subclass of: reproductive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000310
definition: a reproductive system AE that has an outcome of pain or discomfort in the breast, may be caused by small benign tumors
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21979747
has_MedDRA_id: 10006313
see also: HPO: HP_0100749
see also: SIDER: C0262397

bronchopneumonia AE
type: Class
subclass of: pneumonia AE
definition: a pneumonia AE that has an outcome of acute inflammation of the walls of the smaller bronchial tubes, with irregular areas of consolidation due to spread of inflammation into peribronchiolar alveoli and the alveolar ducts of the lungs
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bronchopneumonia
has_MedDRA_id: 10006469
see also: HPO: HP_0006538
see also: SIDER: C0006285

bronchopulmonary aspergillosis AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that has an outcome of an exaggerated response of the immune system to the fungus Aspergillus
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bronchopulmonary+aspergillosis
has_MedDRA_id: 10006473
see also: HPO: HP_0002724
see also: SIDER: C2350530

bronchospasm AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles
definition editor: DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bronchospasm
has_MedDRA_id: 10006482
see also: HPO: HP_0002099
see also: SIDER: C0006266

burning sensation AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that results in a feeling of burning
definition editor: DJ, SS, YH
has_MedDRA_id: 10006784

cachexia AE
type: Class
subclass of: syndrome AE
definition: a syndrom AE that has an outcome of a wasting syndrome characterized by weight loss, muscle atrophy, fatigue, and loss of appetite, often occurs with cancer.
definition editor: DJ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Wasting+Syndrome Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23279159
has_MedDRA_id: 10006895
see also: HPO: HP_0004326
see also: SIDER: C0006625

cecitis AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001153
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE that has an outcome of inflammation of the caecum, part of the large intestine
definition editor: DJ, SS, YH
alternative term: caecitis AE
alternative term: typhlitis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/caecitis
has_MedDRA_id: 10006919
has_MedDRA_id: 10045271
see also: CTCAE: E11058
see also: NCIt: C38043

calcium deficiency AE
type: Class
subclass of: endocrine system AE
definition: an endocrine system AE that has an outcome of deficiency of calcium in the body
definition editor: DJ, SS, YH
has_MedDRA_id: 10006956

capillary leak syndrome AE
type: Class
subclass of: cardiovascular AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001982
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiovascular disorder AE that has an outcome of self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the circulatory system to the interstitial space, resulting in hypotension, hemoconcentration, and hypoalbuminemia
definition editor: DJ, SS, YH, MW
alternative term: Clarkson's Disease AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22873043
has_MedDRA_id: 10007196

carcinoembryonic antigen increased AE
type: Class
subclass of: cytogenetic investigation result abnormal AE
definition: a cytogenetic investigation result abnormal AE that has an outcome of an increase in a type of protein typically associated with tumors and the developing fetus
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.medicinenet.com/carcinoembryonic_antigen/article.htm
has_MedDRA_id: 10007266

carcinoid tumor AE
type: Class
subclass of: tumor AE
definition: a tumor AE that has an outcome of a carcinoid tumor that forms somewhere in the body
definition editor: DJ, SS, YH
alternative term: carcinoid tumour AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307266
has_MedDRA_id: 10007275
see also: HPO: HP_0006723
see also: SIDER: C0007095

hypochloremia AE
type: Class
subclass of: blood chloride abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood chloride decreased
definition: a blood chloride abnormal AE with an outcome of decrease in amount of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease
definition editor: YH, MW
definition source: WEB: https://en.wikipedia.org/wiki/Hypochloremia
has_MedDRA_id: 10020957
see also: HPO: HP_0003113
see also: UMLS CUI: C0085680

cardiac failure AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: hypertension AE
subclass of: Restriction
  on property: is evidence of
  some values from: hypotension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body
definition editor: DJ, SS, YH
alternative term: heart failure
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cardiac+failure
has_MedDRA_id: 10007554
has_MedDRA_id: 10019279
see also: CTCAE: E10124
see also: HPO: HP_0001635
see also: NCIt: C50577
see also: SIDER: C0018801

cardiac failure congestive AE
type: Class
subclass of: cardiac failure AE
definition: a cardiovascular disorder AE that results in an inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body
definition editor: DJ, SS, YH
alternative term: congestive heart failure
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/congestive+heart+failure Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/21676684
has_MedDRA_id: 10007559
see also: HPO: HP_0001635
see also: SIDER: C0018802

cardiac pacemaker insertion
type: Class
subclass of: surgery
definition: a surgery that implants a cardiac pacemaker, a device that supplies electrical impulses to the heart to maintain the heartbeat at a regular rate
definition editor: DJ, SS, YH
definition source: WEB: http://www.mdguidelines.com/cardiac-pacemaker-insertion
has_MedDRA_id: 10007598

cardiac valve disease AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE that has an outcome of disease involving one or more of the valves of the heart
definition editor: DJ, SS, YH
alternative term: valvular disease AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/valvular+heart+disease
has_MedDRA_id: 10061406
see also: HPO: HP_0001654
see also: SIDER: C0018824

cardiac ventricular disorder AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: a cardiac disorder AE that has an outcome of a disorder involving the ventricle(s) in the heart
definition editor: DJ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/ventricular Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/15473469
has_MedDRA_id: 10057455

cardiogenic shock AE
type: Class
subclass of: hypotension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: a hypotension AE that has an outcome of the inability of the heart to supply enough blood to the organs of the body because of heart damage
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001237/
has_MedDRA_id: 10007625

cardiomyopathy AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: hypertension AE
subclass of: Restriction
  on property: is evidence of
  some values from: hypotension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac failure AE
definition: a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy
definition source: WEB: https://en.wikipedia.org/wiki/Cardiomyopathy
has_MedDRA_id: 10007636
see also: HPO: HP_0001638
see also: SIDER: C0878544

cardiotoxicity AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiovascular disorder AE that has an outcome of heart electrophysiology dysfunction and/or muscle damage. Is not efficient at pumping/circulating blood
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy
has_MedDRA_id: 10048610

carotid arteriosclerosis AE
type: Class
subclass of: coronary artery disorder AE
definition: a coronary artery disorder AE that results in lesion in carotid artery
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/8198401
has_MedDRA_id: 10067116

cataplexy AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal system AE that has an outcome of loss of muscle tone due to emotional responses like laughing and crying
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cataplexy
has_MedDRA_id: 10007737
see also: HPO: HP_0002524
see also: SIDER: C0007384

cataract AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a eye disorder AE that results in cloudiness that develops in the eye
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cataract
has_MedDRA_id: 10007739
see also: CTCAE: E10350
see also: HPO: HP_0000518
see also: NCIt: C26713
see also: SIDER: C0086543

catheter related complication AE
type: Class
subclass of: surgery adverse event
definition: a sugery AE that has an adverse outcome related to the use of catheter, a thin tube inserted in the body
definition editor: DJ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23306712
has_MedDRA_id: 10052253

catheter related infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an infection AE that has an outcome of an infection (e.g., bacterial colonisation) at the catheter site
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/8825104
has_MedDRA_id: 10007810
has_MedDRA_id: 10056520
see also: CTCAE: E11328
see also: HPO: HP_0002719
see also: NCIt: C78232
see also: SIDER: C0860239

catheter site infection AE
type: Class
subclass of: infection AE
definition: a bacterial infection AE that is located at the catheter site
definition editor: DJ, SS, YH
has_MedDRA_id: 10056520

catheter site related reaction AE
type: Class
subclass of: surgery adverse event
definition: a sugery AE that has an adverse outcome at the site where a catheter was used
definition editor: DJ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23074085
has_MedDRA_id: 10007811

catheterization cardiac abnormal AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE that has an outcome of a problem after inserting a catheter into the heart
definition editor: DJ, SS, YH
alternative term: catheterisation cardiac abnormal AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cardiac+catheterization
has_MedDRA_id: 10007816

cauda equina syndrome AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of an acute loss of function of the lumbar plexus
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23230403
has_MedDRA_id: 10007821

central line infection AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE that is located at the central-line catheter site
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/7580945
has_MedDRA_id: 10054192
see also: HPO: HP_0002719
see also: SIDER: C1096243

central nervous system infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001017
definition: an infection AE that is located in the central nervous system
definition editor: DJ, SS, YH
has_MedDRA_id: 10061036
see also: HPO: HP_0005381
see also: SIDER: C0007684

central nervous system lymphoma AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001017
definition: a tumor AE that has an outcome of lymphoma in the central nervous system
definition editor: DJ, SS, YH
has_MedDRA_id: 10007953

cerebellar ataxia AE
type: Class
subclass of: ataxia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: an ataxia AE that is located in the cerebellum
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23283615
has_MedDRA_id: 10008025
see also: HPO: HP_0001251
see also: SIDER: C0007758

cerebellar syndrome AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain disorder AE that has an outcome of an inherited brain disorder that affects muscle coordination, may involve the tendency for limb movements to overshoot or undershoot a target, tremors and impaired rhythm
definition editor: DJ, SS, YH
definition source: WEB: http://www.rightdiagnosis.com/medical/cerebellar_syndrome.htm
has_MedDRA_id: 10008072
see also: HPO: HP_0001317
see also: SIDER: C0007760

cerebral hemorrhage AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain disorder AE with the outcome of hemorrhage or blood in the brain
definition editor: DJ, SS, YH
alternative term: cerebral haemorrhage AE
has_MedDRA_id: 10008111
see also: HPO: HP_0001342
see also: SIDER: C2937358

cerebral ischemia AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain disorder AE that results in the sudden death of brain cells in a localized area due to inadequate blood flow
definition editor: DJ, SS, YH
alternative term: cerebral ischaemia AE
alternative term: ischemic stroke AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Cerebral+ischaemia
has_MedDRA_id: 10008120
see also: HPO: HP_0002637
see also: SIDER: C0917798

cervicobrachial syndrome AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that has an outcome of pain or another sensation in the patient's neck and shoulder region
definition editor: DJ, SS, YH
definition source: WEB: http://www.mdguidelines.com/cervicobrachial-syndrome/definition
has_MedDRA_id: 10008334

chapped lips AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of dry lips caused by the evaporation of moisture.
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/9433089
has_MedDRA_id: 10049047

cheilitis AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001833
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an inflammation AE that occurs in the lip
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cheilitis
has_MedDRA_id: 10008417
see also: CTCAE: E10517
see also: HPO: HP_0100825
see also: NCIt: C79545
see also: SIDER: C0007971

chemical burn of skin AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a burn due to chemicals on the skin
definition editor: DJ, SS, YH
has_MedDRA_id: 10057941

chest discomfort AE
type: Class
subclass of: discomfort AE
definition: a discomfort AE that has an outcome of pain in the chest
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/chest+pain
has_MedDRA_id: 10008469
see also: HPO: HP_0001681
see also: SIDER: C0235710

alcohol cardiomyopathy AE
type: Class
subclass of: toxin-induced cardiomyopathy AE

chloroma AE
type: Class
subclass of: tumor AE
definition: a progressive tumor AE that has an outcome of multiple, malignant, localized green masses of abnormal cells, usually myeloblasts, especially beneath the periosteum of the skull, spine and ribs
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/chloroma
has_MedDRA_id: 10008583

cholangitis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of infection in the common bile duct, usually by bacterial infection
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001335/
has_MedDRA_id: 10008604
see also: HPO: HP_0011040
see also: SIDER: NA

cholestasis AE
type: Class
subclass of: hepatobiliary or pancreatic AE
definition: a liver/biliary system AE that has an outcome of a condition in which the flow of bile from the liver is slowed or blocked
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001263/
has_MedDRA_id: 10008635
see also: HPO: HP_0001396
see also: SIDER: C0008370

chondrocalcinosis pyrophosphate AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: an adverse event that has an outcome of calcium crystals of calcium pyrophosphate dihydrate accumulated in the connective tissues of the patient
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/chondrocalcinosis
has_MedDRA_id: 10008690

chromosome analysis abnormal AE
type: Class
subclass of: cytogenetic investigation result abnormal AE
definition: a cytogenetic investigation result abnormal AE that has an outcome of an abnormal chromosome pattern
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.miscarriageclinic.co.uk/causes-and-treatments/chromosome-abnormality/
has_MedDRA_id: 10008817

chemotherapy-induced peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
definition: a peripheral neuropathy AE which has an outcome of a chemotherapy-induced neuropathy that affects nerves of the peripheral nervous system (PNS)
definition editor: AG, YH
alternative term: CIPN
definition source: WEB: http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/chemotherapyeffects/peripheralneuropathy/peripheral-neuropathy-caused-by-chemotherapy-what-is-cipn

chronic myeloid leukemia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by increased and unregulated growth of myeloid cells in the bone marrow
definition editor: DJ, SS, YH
alternative term: chronic myeloid leukaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/chronic+myelogenous+leukemia
has_MedDRA_id: 10009013
see also: HPO: HP_0005506
see also: SIDER: C0023473

chronic myeloid leukemia transformation AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. May transform from chronic myeloid leukaemia to acute myeloid leukaemia
definition editor: DJ, SS, YH
alternative term: chronic myeloid leukaemia transformation AE
definition source: WEB: http://www.jci.org/articles/view/41246
has_MedDRA_id: 10068232

chronic obstructive pulmonary disease AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of breathing difficulty with two main forms: chronic bronchitis and emphysema
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001153/
has_MedDRA_id: 10009033
see also: HPO: HP_0006510
see also: SIDER: C0024117

chronic respiratory failure AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that results in inadequate gas exchange by the respiratory system
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/respiratory+failure
has_MedDRA_id: 10009126

chronic sinusitis AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of inflammation in the cavities around the nasal passages
definition editor: DJ, SS, YH
definition source: WEB: http://www.mayoclinic.com/health/chronic-sinusitis/DS00232
has_MedDRA_id: 10009137

chylothorax AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung disorder AE that has an outcome of lymphatic fluid accumulating in the pleural cavity, the space between two pleura of the lungs
definition editor: DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/chylothorax
has_MedDRA_id: 10051228

circulatory collapse AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that has an outcome of insufficient circulation without congestive heart failure
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/circulatory+collapse
has_MedDRA_id: 10009192

clostridial infection AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE that has an outcome of invasion by anaerobic bacteria of the genus Clostridium, can cause tetanus and botulism
definition editor: DJ, SS, YH
definition source: WEB: http://www.medicinenet.com/clostridium_difficile_colitis/page2.htm
has_MedDRA_id: 10061043
see also: HPO: HP_0004798
see also: SIDER: C0009062

clostridium difficile colitis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of bacterial infection by clostridium difficile colitis, commonly results in diarrhea and colitis
definition editor: DJ, SS, YH
has_MedDRA_id: 10009657
see also: HPO: HP_0002583
see also: SIDER: C0238106

coagulation factor v level decreased AE
type: Class
subclass of: coagulation factor v level abnormal AE
definition: a coagulation factor v level abnormal AE that has an outcome of a decreased level of the factor V protein in the coagulation system of the body
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22781721
has_MedDRA_id: 10009754

colitis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0001007
definition: an inflammation AE that occurs at the large intestine
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002112/
has_MedDRA_id: 10009887
see also: CTCAE: E10521
see also: HPO: HP_0002583
see also: NCIt: C26723
see also: SIDER: C0009319

collapse of lung AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of a collapsed lung, refering to the space between the wall of the chest cavity and the lung filling with air, causing all or a portion of the lung to collapse
definition editor: DJ, SS, YH
alternative term: Pneumothorax
has_MedDRA_id: 10009913

colon cancer AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001155
definition: a tumor AE that has an outcome of cancer that starts in the large intestine or the rectum
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/
has_MedDRA_id: 10009944
see also: HPO: HP_0003003
see also: SIDER: C0007102

colon cancer metastatic AE
type: Class
subclass of: colon cancer AE
definition: a colon AE that has an outcome of cancerous cells spreading to the colon
definition editor: DJ, SS, YH
definition source: WEB: http://www.cancer.gov/cancertopics/factsheet/Sites-Types/metastatic
has_MedDRA_id: 10055114

colon cancer stage iv AE
type: Class
subclass of: colon cancer AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001155
definition: a colon cancer AE that has an outcome of colon cancer at stage IV
definition editor: DJ, SS, YH
has_MedDRA_id: 10009956

colorectal cancer AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of cancer that starts in the large intestine or rectum.
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/
has_MedDRA_id: 10061451
see also: HPO: HP_0003003
see also: SIDER: C1527249

colorectal cancer metastatic AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of cancer in the large intestine and the rectum. When metastatic, the cancer has already spead to distant sites and is considered stage IV.
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22642873
has_MedDRA_id: 10052358
see also: HPO: HP_0003003
see also: SIDER: C0948380

computerized tomography result abnormal AE
type: Class
subclass of: imaging investigation result abnormal AE
definition: an imaging investigation result abnormal AE that has an abnormal result of an imaging method in which a cross-sectional image of the structures in a body plane is reconstructed by a computer program from the x-ray absorption of beams projected through the body in the image plane
definition editor: DJ, SS, YH, EB
alternative term: computerised tomogram abnormal AE
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/computerized+tomography , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23271098
definition source: WEB: http://medical-dictionary.thefreedictionary.com/computed+tomography
has_MedDRA_id: 10010235

concomitant disease progression AE
type: Class
subclass of: systematic AE
definition: an adverse event that has an outcome of progression of underlying conditions that may affect drug distribution or metabolism
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Concomitant+disease
has_MedDRA_id: 10048659

condition aggravated AE
type: Class
subclass of: systematic AE
definition: an adverse event that has an outcome of condition that worsens
definition editor: DJ, SS, YH
has_MedDRA_id: 10010264

congenital cardiovascular anomaly AE
type: Class
subclass of: congenital AE
definition: a congenital abnormality AE that has an outcome of an abnormality in heart which is present at birth
definition editor: DJ, SS, YH
definition source: WEB: http://www.thefreedictionary.com/congenital+heart+defect
has_MedDRA_id: 10061054
see also: HPO: HP_0001626
see also: SIDER: C0243050

congestive cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE
definition: a cardiomyopathy AE that is characterized by the walls of the heart chambers stretching to hold a greater volume of blood than normal
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/congestive+cardiomyopathy
has_MedDRA_id: 10056370
see also: HPO: HP_0001635
see also: SIDER: C0007193

conjunctival disorder AE
type: Class
subclass of: eye AE
definition: an eye disorder AE that has an outcome of a problem involving the insides of the patient's eyelids
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/conjunctiva
has_MedDRA_id: 10061446
see also: HPO: HP_0000502
see also: SIDER: C0009759

conjunctival hemorrhage AE
type: Class
subclass of: hemorrhage AE
definition: a hemorrhage AE that has an outcome of a bright hemorrhagic patch on the bulbar conjunctiva caused by rupture and bleeding of a superficial small capillary due to increased pressure
definition editor: DJ, SS, YH
alternative term: conjunctival haemorrhage AE
has_MedDRA_id: 10010719
see also: HPO: HP_0007902
see also: SIDER: C0009760

connective tissue disorder AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: an adverse event that has an outcome of disease in the biological tissue that supports, binds together and protects organs
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/connective+tissue+disease
has_MedDRA_id: 10061087
see also: HPO: HP_0003549
see also: SIDER: C0009782

contact lens intolerance AE
type: Class
subclass of: eye AE
definition: an eye disorder AE that has a result of the inability to use contact lenses
definition editor: DJ, SS, YH
has_MedDRA_id: 10010804

coombs' test positive AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that has an outcome of a positive coombs test, which is a blood test that identifies the causes of anemia
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Coombs'+Tests
definition source: WEB: http://medical-dictionary.thefreedictionary.com/test
has_MedDRA_id: 10061090

coordination abnormal AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in a loss of coordination
definition editor: DJ, SS, YH
has_MedDRA_id: 10010947
see also: HPO: HP_0011443
see also: SIDER: C0520966

coronary angioplasty AE
type: Class
subclass of: medical intervention
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001621
definition: a cardiac disorder AE that has an outcome of treatment involving the stenotic coronary arteries in the heart
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/coronary+angioplasty
has_MedDRA_id: 10050329

coronary artery embolism AE
type: Class
subclass of: coronary artery disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001621
definition: a coronary artery disorder AE that has an outcome of an blockage in the coronary artery
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22953315
has_MedDRA_id: 10011084

coronary artery insufficiency AE
type: Class
subclass of: coronary artery disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001621
definition: a coronary artery disorder AE that has an outcome of an insufficient amount of blood circulates through the coronary arteries
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/coronary+insufficiency
has_MedDRA_id: 10052895
see also: HPO: HP_0001677
see also: SIDER: C0542052

craniopharyngioma AE
type: Class
subclass of: tumor AE
definition: a tumor AE that has an outcome of a brain tumor derived from the embryonic tissue of the pituitary gland
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/craniopharyngioma
has_MedDRA_id: 10011318

c-reactive protein level increased AE
type: Class
subclass of: c-reactive protein level abnormal AE
definition: a c-reactive protein level abnormal AE that has an outcome of an increased amount of CRP, a protein that measure general levels of inflammation in the body
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.webmd.com/a-to-z-guides/c-reactive-protein-crp
curator note: moved "c-reactive protein increased AE" from "cardiac AE" to "lab test abnormal AE" EB
has_MedDRA_id: 10006825

viral cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE

csf pressure increased AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that has an outcome of increased pressure in the skull
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/intracranial+pressure
has_MedDRA_id: 10011570

culture urine positive AE
type: Class
subclass of: urine analysis result abnormal AE
definition: a urine analysis result abnormal AE that has an outcome of high bacterial colonization counts in the urine
definition editor: DJ, SS, YH, EB
definition source: WEB: http://labtestsonline.org/understanding/analytes/urine-culture/tab/test
has_MedDRA_id: 10011640

cutaneous vasculitis AE
type: Class
subclass of: vasculitis AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002097
definition: an inflammation AE that has an outcome of inflamed blood vessels in the skin
definition editor: DJ, SS, YH
definition source: WEB: http://dermnetnz.org/vascular/vasculitis.html
Chinese translation: 皮肤血管炎
has_MedDRA_id: 10011686
see also: HPO: HP_0200029
see also: SIDER: C0262988

cystitis hemorrhagic AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE that has an outcome of cystitis with severe hemorrhage, a dose-limiting toxic condition with administration of ifosfamide and cyclophosphamide or a complication of bone marrow transplantation
definition editor: DJ, SS, YH
alternative term: cystitis haemorrhagic AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+cystitis
has_MedDRA_id: 10011793

cytogenetic abnormality AE
type: Class
subclass of: genetic AE
definition: a genetic disorder AE that has an outcome of an atypical number of chromosomes or a structural abnormality in one or more chromosomes
definition editor: DJ, SS, YH
has_MedDRA_id: 10067477

cytokine release syndrome AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has an outcome of release of cytokines by T cells that causes inflammation
definition editor: DJ, SS, YH
definition source: WEB: http://encyclopedia.thefreedictionary.com/cytokine+release+syndrome
has_MedDRA_id: 10052015
see also: CTCAE: E11264
see also: NCIt: C78251

cytolytic hepatitis AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE that has an outcome of liver cells carrying excess water, causing inflammation along with hepatitis
definition editor: DJ, SS, YH
definition source: WEB: http://www.thirdage.com/hc/c/q/hepatitis/1550008/what-is-cytolytic-hepatitis
has_MedDRA_id: 10050904
see also: HPO: HP_0004787
see also: SIDER: C0919823

cytomegalovirus colitis AE
type: Class
subclass of: inflammation AE
definition: an inflammation AE that results in the inflammation of the colon
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22874621
has_MedDRA_id: 10048983

cytomegalovirus infection AE
type: Class
subclass of: viral infection AE
definition: a viral infection AE that is caused by cytomegalovirus
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/cytomegalovirusinfections.html
has_MedDRA_id: 10011831
see also: HPO: HP_0004429
see also: SIDER: C0010823

dandruff AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of shedding of the dead skin cells from the scalp
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dandruff
has_MedDRA_id: 10011859
see also: HPO: HP_0001051
see also: SIDER: C0221244

debridement
type: Class
subclass of: surgery
definition: a surgery that performs a medical removal of dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue
definition editor: DJ, SS, YH, SJ
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Debridement
definition source: WEB: http://www.surgeryencyclopedia.com/Ce-Fi/Debridement.html
has_MedDRA_id: 10057612
has_MedDRA_id: 10067806

decubitus ulcer AE
type: Class
subclass of: skin ulceration AE
definition: a skin ulcer AE that has an outcome of localized injuries to the skin and/or underlying tissue usually over a bony prominence as a result of pressure
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pressure+ulcer
has_MedDRA_id: 10011985
see also: HPO: HP_0200042
see also: SIDER: C0011127

deep vein thrombosis AE
type: Class
subclass of: venous thrombosis AE
definition: a venous thrombosis that is characterized by a blood clot that forms in a vein deep in the body. Blood clots occur when blood thickens and clumps together. Most deep vein blood clots occur in the lower leg or thigh. They also can occur in other parts of the body.
definition editor: DJ, SS, YH
alternative term: DVT
definition source: WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/dvt/
curator note: Moved from Cardiac AE to thombosis AE by LB
has_MedDRA_id: 10051055
see also: HPO: HP_0004850
see also: SIDER: C0149871

delirium AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that results in a decline in level of cognitive function
definition editor: DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/delirium
has_MedDRA_id: 10012218

dental caries AE
type: Class
subclass of: tooth disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a tooth disorder AE that has an outcome of bacterial infection that causes demineralization and destruction of the hard tissues, resulting in dental cavities
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dental+caries
has_MedDRA_id: 10012318
see also: CTCAE: E10568
see also: HPO: HP_0000670
see also: NCIt: C52593
see also: SIDER: C0011334

depressed level of consciousness AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a sensory capability AE that results in a lower level of arousal than normal
definition editor: DJ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23167919
has_MedDRA_id: 10012373
see also: HPO: HP_0004372
see also: SIDER: C0549249

dermatitis acneiform AE
type: Class
subclass of: dermatitis AE
definition: a dermatitis ae that is characterized by the eruption of papules and pustules, typically on the face, scalp, upper chest and back.
definition editor: DJ, SS, YH
definition source: WEB: https://www.medify.com/conditions/acneiform-dermatitis
has_MedDRA_id: 10012432
see also: HPO: HP_0001051
see also: SIDER: C0234894

dermatitis exfoliative AE
type: Class
subclass of: dermatitis AE
definition: a dermatitis ae that is characterized by an inflammatory skin disease with erythmea and scaling, that has an outcome of widespread scaling of the skin, often with itching, skin redness and hair loss
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001610.htm
has_MedDRA_id: 10012455
see also: HPO: HP_0011123
see also: SIDER: C0011606

dermatomyositis AE
type: Class
subclass of: muscle AE
definition: a muscle AE that has an outcome of muscle weakness, inflammation, skin rash and difficulty swallowing
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001842/
has_MedDRA_id: 10012503

developmental coordination disorder AE
type: Class
subclass of: motor neuropathy AE
definition: a motor neuropathy AE that has an outcome of poor coordination
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001533.htm
has_MedDRA_id: 10012557

device dislocation AE
type: Class
subclass of: medical device adverse event
definition: an injury and procedural complication AE that results in the dislocation of a device
definition editor: DJ, SS, YH
has_MedDRA_id: 10064684

device expulsion AE
type: Class
subclass of: medical device adverse event
definition: an injury and procedural complication AE that results in the expulsion (vomiting) of medical device from body
definition editor: DJ, SS, YH
has_MedDRA_id: 10012578

device related infection AE
type: Class
subclass of: medical device adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an injury and procedural complication AE that results in an infection related to medical device
definition editor: DJ, SS, YH
has_MedDRA_id: 10064687
see also: CTCAE: E11356
see also: HPO: HP_0002719
see also: NCIt: C79705
see also: SIDER: C1619702

diabetic hyperglycemic coma AE
type: Class
subclass of: coma AE
definition: a coma AE which is induced by the condition that the patient has extremely high levels of sugar in the blood without ketones
definition editor: DJ, SS, YH
alternative term: diabetic hyperglycaemic coma AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000304.htm
has_MedDRA_id: 10012668

diaphragmatic hernia AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of an abnormal hole in the diaphragm
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23288807
has_MedDRA_id: 10012713
see also: HPO: HP_0000776
see also: SIDER: C0019284

diaphragmatic paralysis AE
type: Class
subclass of: paralysis AE
definition: a paralysis AE that has an outcome of a paralyzed diaphragm
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19452391
has_MedDRA_id: 10012725

diarrhea hemorrhagic AE
type: Class
subclass of: diarrhea AE
definition: a diarrhea AE that has an outcome of rectal bleeding and bloody diarrhea
definition editor: DJ, SS, YH
alternative term: diarrhoea haemorrhagic AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19292138
has_MedDRA_id: 10012741
see also: HPO: HP_0002255
see also: SIDER: C0151594

diarrhea infectious AE
type: Class
subclass of: diarrhea AE
definition: a diarrhea AE that has an outcome of diarrhea is caused by infection
definition editor: DJ, SS, YH
alternative term: diarrhoea infectious AE
has_MedDRA_id: 10012742

diastolic dysfunction AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE with an outcome of decline in performance of one or both ventricles of the heart during the time phase of diastole, when heart filling with incoming blood
definition editor: DJ, SS, YH
definition source: WEB: http://encyclopedia.thefreedictionary.com/diastolic+dysfunction
has_MedDRA_id: 10052337

dilatation ventricular AE
type: Class
subclass of: cardiac ventricular disorder AE
definition: a cardiac ventricular disorder AE that has an outcome of enlargement of a heart chamber that pumps blood away from the heart
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721391/
has_MedDRA_id: 10013012

disease progression AE
type: Class
subclass of: systematic AE
definition: an adverse event with an outcome of worsening of the disease
definition editor: DJ, SS, YH
has_MedDRA_id: 10061818
see also: HPO: HP_0004738
see also: SIDER: C0242656

dislocation of vertebra AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of dislocation of vertebra
definition editor: DJ, SS, YH
has_MedDRA_id: 10013183

disorientation AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that results in the senses of time, direction, and recognition of people and places becoming difficult to distinguish
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/disorientation
has_MedDRA_id: 10013395
see also: HPO: HP_0001289
see also: SIDER: C0233407

disseminated intravascular coagulation AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hematopoietic system AE with an outcome of a serious disorder in which proteins that control blood clotting become abnormally active
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000573.htm
has_MedDRA_id: 10013442
see also: CTCAE: E10028
see also: HPO: HP_0005521
see also: NCIt: C2992
see also: SIDER: C0012739

disturbance in attention AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in a loss of attention
definition editor: DJ, SS, YH
has_MedDRA_id: 10013496
see also: HPO: HP_0007018
see also: SIDER: C0233414

diverticular perforation AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE with an outcome of perforation of small sacs or pockets in the wall of the colon
definition editor: DJ, SS, YH
definition source: WEB: http://www.webmd.com/digestive-disorders/diverticular-disease
has_MedDRA_id: 10061820

diverticulitis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of infection and inflammation in the small, bulging sacs or pouches of the inner lining of the intestine
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001303/
has_MedDRA_id: 10013538
see also: HPO: HP_0002253
see also: SIDER: C0012813

diverticulitis intestinal hemorrhagic AE
type: Class
subclass of: digestive system AE
definition: a hemorrhage AE that has an outcome of bleeding in the intestine due to diverticulitis
definition editor: DJ, SS, YH
alternative term: diverticulitis intestinal haemorrhagic AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780263/
has_MedDRA_id: 10013541

drug clearance decreased AE
type: Class
subclass of: adverse drug event
definition: an adverse event that has an outcome of a decreased amount of the drug excreted by the body
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/drug+clearance
has_MedDRA_id: 10049463

drug dependence AE
type: Class
subclass of: adverse drug event
definition: an adverse drug event that results in the development of a dependence on the drug
definition editor: DJ, SS, YH
has_MedDRA_id: 10013663
see also: HPO: HP_0000722
see also: SIDER: C1510472

drug eruption AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a range of adverse drugs reactions of the skin, most commonly rashes resembling measles
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption
has_MedDRA_id: 10013687

drug hypersensitivity AE
type: Class
subclass of: hypersensitivity AE
definition: a hypersensitivity AE that has an outcome of allergic reactions to certain drugs
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23192511
has_MedDRA_id: 10013700
see also: HPO: HP_0100326
see also: SIDER: C0013182

drug intolerance AE
type: Class
subclass of: adverse drug event
definition: a drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/drug+intolerance
has_MedDRA_id: 10061822

drug withdrawal headache AE
type: Class
subclass of: headache AE
definition: a headache AE that has an outcome of headaches due to drug withdrawal
definition editor: DJ, SS, YH
has_MedDRA_id: 10013753

drug withdrawal syndrome AE
type: Class
subclass of: adverse drug event
definition: an adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/withdrawal
has_MedDRA_id: 10013754

dry skin AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin AE that is characterized by epidermis that lacks moisture, has an outcome of fine lines, scaling and itching
definition editor: DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dry+skin
has_MedDRA_id: 10013786
see also: HPO: HP_0000958
see also: SIDER: C0151908

duodenal ulcer AE
type: Class
subclass of: OAE_0004230
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a duodenum AE that has an outcome of a peptic ulcer, or a defect in the lining of the stomach or the first part of the small intestine, located in the duodenum
definition editor: DJ, SS, YH
alternative term: peptic ulcer AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
has_MedDRA_id: 10013836
see also: CTCAE: E10611
see also: HPO: HP_0002588
see also: NCIt: C26755
see also: SIDER: C0013295

duodenal ulcer hemorrhage AE
type: Class
subclass of: duodenal ulcer AE
definition: a duodenal ulcer AE with an outcome of bleeding in an ulcer, or a defect, in the lining of the stomach or first part of the small intestine called the duodenum
definition editor: DJ, SS, YH
alternative term: duodenal ulcer haemorrhage AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
has_MedDRA_id: 10013839
see also: HPO: HP_0002588
see also: SIDER: C0151966

duodenal ulcer perforation AE
type: Class
subclass of: duodenal ulcer AE
definition: a duodenal ulcer AE that has an outcome of perforation, or complete penetration, of an ulcer located in an area of the small intestine called the duodenum
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
has_MedDRA_id: 10013849
see also: HPO: HP_0002588
see also: SIDER: C0740401

dysarthria AE
type: Class
subclass of: speech disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a speech disorder that results in a motor speech disorder
definition editor: DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dysarthria
has_MedDRA_id: 10013887
see also: HPO: HP_0001260
see also: SIDER: C0013362

dyslexia AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavioral and neurological AE that results in difficulty reading (mixing up letters)
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dyslexia
has_MedDRA_id: 10013932
see also: HPO: HP_0010522
see also: SIDER: C0476254

dysphonia AE
type: Class
subclass of: speech disorder AE
definition: a speech disorder AE that results in disorders of voice
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dysphonia
has_MedDRA_id: 10013952
see also: HPO: HP_0001618
see also: SIDER: C1527344

dyspnoea exertional AE
type: Class
subclass of: respiratory system AE
definition: a dyspnoea AE that has an outcome of shortness of breath during exercise, produces a sensation of not being able to get enough air
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22760109
has_MedDRA_id: 10013971
see also: HPO: HP_0002875
see also: SIDER: C0231807

dysuria AE
type: Class
subclass of: urinary system AE
definition: Dysuria AE is an urinary system AE that results in painful urination
definition editor: JX, DJ, SS, YH
alternative term: urination disorders AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dysuria
Chinese translation: 排尿困难
has_MedDRA_id: 10013990
see also: HPO: HP_0100518
see also: SIDER: C0013428

eating disorder AE
type: Class
subclass of: gustatory system AE
definition: a gustatory system AE which has an outcome of abrnormal or disturbed eating habits
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/eating+disorder
has_MedDRA_id: 10014062

ectopic pregnancy with intrauterine device AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that results in an ectopic pregnancy that occurs along with the use of an IUD
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/ectopic+pregnancy
has_MedDRA_id: 10067037

eczema AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a long term skin disorder that involves scaly and itchy rashes
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001856/
has_MedDRA_id: 10014184
see also: HPO: HP_0000964
see also: SIDER: C0013595

effusion AE
type: Class
subclass of: abnormal fluid regulation AE
definition: an abnormal fluid regulation AE that has an outcome of escape of a fluid into a part
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/effusion
has_MedDRA_id: 10063045

ejaculation delayed AE
type: Class
subclass of: male reproductive system AE
definition: a male reproductive system AE that has an outcome of a delay of ejaculation
definition editor: DJ, SS, YH
has_MedDRA_id: 10014325
see also: HPO: HP_0000022
see also: SIDER: NA

ejection fraction decreased AE
type: Class
subclass of: left ventricular dysfunction AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a left ventricular dysfunction AE that has an outcome of decreased percentage of blood leaving the heart each time it contracts
definition editor: DJ, SS, YH
definition source: WEB: http://www.mayoclinic.com/health/ejection-fraction/AN00360
has_MedDRA_id: 10050528
see also: CTCAE: E12142
see also: NCIt: C83492

electrocardiogram result abnormal AE
type: Class
subclass of: cardiac function test abnormal AE
definition: a cardiac function test abnormal AE that has an outcome of abnormal electrical activity in the heart
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003868.htm
has_MedDRA_id: 10014363

electrocardiogram qrs complex abnormal AE
type: Class
subclass of: electrocardiogram result abnormal AE
definition: an electrocardiogram result abnormal AE that has an outcome of an abnormal depolarization of the right and left ventricles of the heart that is detected on an electrocardiogram test
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23238367
has_MedDRA_id: 10014378

electrocardiogram qt prolonged AE
type: Class
subclass of: electrocardiogram result abnormal AE
definition: an electrocardiogram result abnormal AE that has an outcome of a prolonged time between the start of the Q wave and the end of the T wave in the heart's electrical cycle; a biomarker for ventricular tachyarrhythmias
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23275261
has_MedDRA_id: 10014387
see also: HPO: HP_0001657
see also: SIDER: C0151878

electrocardiogram t wave peaked AE
type: Class
subclass of: electrocardiogram result abnormal AE
definition: an electrocardiogram result abnormal AE in which the T wave appears increased in amplitude and cresting at a point
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301064; http://www.medaphile.com/medical-dictionary/t-wave-peaked
has_MedDRA_id: 10014396

electrolyte imbalance AE
type: Class
subclass of: homeostasis AE
definition: a homeostasis AE that has an outcome of abnormalities in electrolytes (sodium, potassium, calcium)
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/electrolyte+imbalance
has_MedDRA_id: 10014418
see also: HPO: HP_0003111
see also: SIDER: C0342579

emotional disorder AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that results in an abnormal expression of emotions
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/emotional+disorder
has_MedDRA_id: 10014551
see also: HPO: HP_0100851
see also: SIDER: C0233459

endocarditis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
definition: an inflammation AE that occurs in the inside lining of the heart chambers and heart valves
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002088/
has_MedDRA_id: 10014665
see also: HPO: HP_0100584
see also: SIDER: C0014118

enteritis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE with an outcome of inflammation in the intestine, especially the small intestine
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/enteritis
has_MedDRA_id: 10014866
see also: HPO: HP_0004387
see also: SIDER: C0014335

enterocolitis AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE that has an outcome of disease in the digestive tract caused by infection
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/enterocolitis
has_MedDRA_id: 10014893
see also: CTCAE: E10627
see also: HPO: HP_0004387
see also: NCIt: C79573
see also: SIDER: C0014356

enterocolitis infectious AE
type: Class
subclass of: infection AE
definition: an digestive system AE that has an outcome of an infection by enteric viruses or enterotoxigenic bacterias, usually in the intestines, that presents with diarrhea, abdominal pain, perianal discomfort, incontinence and hemorrhage.
definition editor: DJ, SS, YH
definition source: WEB: http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0792-2..50022-5--cesec139&isbn=978-1-4377-0792-2&type=bookPage&from=content&uniqId=376758653-2
has_MedDRA_id: 10058838

eosinophil count increased AE
type: Class
subclass of: eosinophil count abnormal AE
definition: an eosinophil count abnormal AE that has an outcome of an increased amount of eosinophils, a type of white blood cell that becomes active with allergic diseases and infections
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003649.htm
has_MedDRA_id: 10014945
see also: HPO: HP_0001880
see also: SIDER: C2240374

eosinophilia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of higher than normal levels of eosinophils, a type of white blood cell
definition editor: DJ, SS, YH
definition source: WEB: http://www.mayoclinic.com/health/eosinophilia/MY00399
has_MedDRA_id: 10014950
see also: HPO: HP_0001880
see also: SIDER: C0014457

erectile dysfunction AE
type: Class
subclass of: male reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a male reproductive system AE that results in the inability to develop/maintain an erection of penis
definition editor: DJ, SS, JX, LW, YH, MW
alternative term: astyphia AE
alternative term: impotence AE
definition source: WEB: http://en.wikipedia.org/wiki/Erectile_dysfunction
Chinese translation: 阳痿/勃起功能障碍
has_MedDRA_id: 10061461
see also: HPO: HP_0008652
see also: SIDER: C0242350

erysipelas AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of an infection caused by a Streptococcus bacteria that causes blisters, fever and skin lesion and sores
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001643/
has_MedDRA_id: 10015145
see also: HPO: HP_0001055
see also: SIDER: C0014733

erythrodermic psoriasis AE
type: Class
subclass of: psoriasis AE
definition: a psoriasis AE that has an outcome of psoriasis that affects all sites on the body
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/psoriatic+erythroderma
has_MedDRA_id: 10015278

escherichia infection AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE with an outcome of invasion by Escherichia coli bacteria, commonly found in the lower intestine and can cause serious food poisoning, but can also be found in various parts of body
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/escherichia+coli
has_MedDRA_id: 10061126

escherichia test positive AE
type: Class
subclass of: microbiology and serology investigation result abnormal AE
definition: a microbiology and serology investigation result abnormal AE that has an outcome of a positive escherichia test
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Escherichia
has_MedDRA_id: 10070090

escherichia urinary tract infection AE
type: Class
subclass of: urinary tract infection AE
definition: an urinary tract infection AE that has an outcome of infection caused by E. coli bacteria
definition editor: DJ, SS, YH
definition source: WEB: http://www.medicinenet.com/urine_infection/article.htm
has_MedDRA_id: 10052238

excessive granulation tissue AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a connective tissue AE that has an outcome of excess perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds.
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19594571
has_MedDRA_id: 10063560

exfoliative rash AE
type: Class
subclass of: rash AE
definition: a rash AE that has an outcome of erythema, desquamation, scaling, itching of the skin and loss of hair
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/exfoliative+dermatitis
has_MedDRA_id: 10064579

exomphalos AE
type: Class
subclass of: congenital AE
definition: a congenital abnormality that results in a weakness of the baby's abdominal wall where the umbilical cord joins it. This weakness allows the abdominal contents to protrude outside the abdominal cavity
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/exomphalos
has_MedDRA_id: 10015677
see also: HPO: HP_0001539
see also: SIDER: C1306503

exposure to contaminated device AE
type: Class
subclass of: medical device adverse event
definition: an injury and procedural complication AE that results in the patient being exposed to a contaminated device
definition editor: DJ, SS, YH
has_MedDRA_id: 10068515

exposure to toxic agent AE
type: Class
subclass of: procedural complication AE
definition: a procedural complication AE that results in the patient being exposed to a toxic agent
definition editor: DJ, SS, YH
has_MedDRA_id: 10053487

extradural abscess AE
type: Class
subclass of: abscess AE
definition: an abscess AE that results in a collection of pus between a person's skull and dura
definition editor: DJ, SS, YH
definition source: WEB: http://www.meb.uni-bonn.de/dtc/primsurg/docbook/html/x1217.html
has_MedDRA_id: 10061846

extraocular muscle paresis AE
type: Class
subclass of: paresis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a paresis AE that results in a partial loss of voluntary movement in their extraocular muscles
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22824489
has_MedDRA_id: 10015829
see also: CTCAE: E10367
see also: NCIt: C78286

coagulopathy AE
type: Class
subclass of: bleeding and coagulation disorders AE
definition: coagulopathy AE results in the impairment of blood to clot causing ecessive or prolonged bleeding.
definition editor: SJ, YH
alternative term: bleeding disorder
alternative term: clotting disorder
definition source: WEB: http://en.wikipedia.org/wiki/Coagulopathy
has_MedDRA_id: 10009802

eye hemorrhage AE
type: Class
subclass of: eye AE
definition: a hemorrhage AE that has an outcome of hemorrhage occuring in the blood vessels in the eye
definition editor: DJ, SS, YH
alternative term: eye haemorrhage AE
alternative term: subconjunctival haemorrhage AE
definition source: WEB: http://www.webmd.com/eye-health/bleeding-in-the-eye
has_MedDRA_id: 10015926
see also: HPO: HP_0011885
see also: SIDER: C0015402

eye swelling AE
type: Class
subclass of: eye AE
definition: a eye disorder AE that has an outcome of swelling in the tissues around the eyes, called the orbits, caused by fluid buildup
definition editor: DJ, SS, YH
alternative term: perioribtal puffiness AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21115963
has_MedDRA_id: 10015967

eyelid edema AE
type: Class
subclass of: OAE_0004244
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0001711
definition: an eye edema AE that has an outcome of swelling in either or both the lower and upper eyelids, due to fluid buildup or inflammation in the delicate tissues surrounding the eye.
definition editor: DJ, SS, YH
alternative term: eyelid oedema AE
definition source: WEB: http://www.localhealth.com/article/eyelid-swelling
has_MedDRA_id: 10015993
see also: HPO: HP_0100539
see also: SIDER: C0162285

failure to thrive AE
type: Class
subclass of: prenatal, perinatal or neonatal disorder AE
definition: A pregnancy, neonatal and perinatal AE that displays the result of failure to thrive (FTT), which refers to a baby or child that is not developing as well as desired.
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000991.htm
definition source: WEB: http://www.stanfordchildrens.org/en/topic/default?id=failure-to-thrive-90-P02297
has_MedDRA_id: 10016165
see also: HPO: HP_0001531
see also: SIDER: C0015544

fall AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a behavior and neurological AE that has an outcome of patient falling
definition editor: DJ, SS, YH
has_MedDRA_id: 10016173
see also: CTCAE: E11687
see also: HPO: HP_0002359
see also: NCIt: C50558
see also: SIDER: C0085639

fear of needles AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in the extreme fear of needles
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23225704
has_MedDRA_id: 10068298

febrile bone marrow aplasia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of inadequate blood cell formation by bone marrow accompanied by a fever
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Bone+marrow+aplasia
has_MedDRA_id: 10053213

febrile infection AE
type: Class
subclass of: infection AE
definition: a fever AE that has an outcome of an infection along/because of a fever
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/febrile
has_MedDRA_id: 10051998

febrile neutropenia AE
type: Class
equivalent class: Class
  intersection of: fever AE
  intersection of: neutropenia AE
subclass of: neutropenia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a neutropenia AE, generally a complication of chemotherapy, that has an outcome of an abnormally low neutrophil granulocyte count, accompanied by fever
definition editor: DJ, SS, YH
alternative term: neutropenic sepsis AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23303687
has_MedDRA_id: 10016288
see also: CTCAE: E10033
see also: HPO: HP_0001875
see also: NCIt: C35665
see also: SIDER: C0746883

feeding tube complication AE
type: Class
subclass of: medical device adverse event
definition: an injury and procedural complication AE that has an outcome of an complication due to the use of enteral feeding tube
definition editor: DJ, SS, YH
alternative term: enteral feeding AE
definition source: WEB: http://www.thirdage.com/hc/p/197842/what-is-tube-feeding
has_MedDRA_id: 10056661

feeling abnormal AE
type: Class
subclass of: sensory capability AE
definition: a sensory capabilty AE that results in the patient feeling different than normal after a medical intervention such as taking drug
definition editor: DJ, SS, YH
has_MedDRA_id: 10016322
see also: HPO: HP_0010870
see also: SIDER: C1443060

feeling hot AE
type: Class
subclass of: feeling abnormal AE
definition: Feeling hot AE is a feeling abnormal AE that a patient feels hot.
definition editor: DJ, SS, YH
has_MedDRA_id: 10016334

hypoesthesia oral AE
type: Class
subclass of: hypoesthesia AE
definition: a hypoaesthesia AE that has an outcome of a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli in the oral area
definition editor: SS, YH
alternative term: hypoaesthesia oral AE
definition source: WEB: http://en.wikipedia.org/wiki/Hypoesthesia
has_MedDRA_id: 10057371
see also: HPO: HP_0010830
see also: SIDER: C0521592

fistula discharge AE
type: Class
subclass of: fistula AE
definition: a fistula AE that has an outcome of discharge that occurs as the result of the connection between two body cavities
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed?term=fistula%20discharge%20%5BTI%5D
has_MedDRA_id: 10067143

fluid intake reduced AE
type: Class
subclass of: abnormal fluid regulation AE
definition: an abnormal fluid regulation AE with an outcome of decrease in ingestion of water or other fluids
definition editor: DJ, SS, YH
has_MedDRA_id: 10056291

fluid overload AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of too much fluid in the blood, can occur due to increase in total body sodium
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22827112
has_MedDRA_id: 10016803

focal nodular hyperplasia AE
type: Class
subclass of: hyperplasia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002107
definition: a hyperplasia AE that has an outcome of a benign tumor in the liver
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/focal+nodular+hyperplasia
has_MedDRA_id: 10052285

fetal heart rate deceleration AE
type: Class
subclass of: congenital AE
definition: a congenital abnormality disorder AE that has an outcome of a decreased heart rate in a fetus
definition editor: DJ, SS, YH
alternative term: foetal heart rate deceleration AE
has_MedDRA_id: 10058322

folliculitis AE
type: Class
subclass of: skin AE
definition: a skin AE with the outcome disease involving of one more more hair follicles, commonly displays rash, itching and pustules near the hair follicles
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001826/
has_MedDRA_id: 10016936

forced expiratory volume decreased AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a respiratory system AE that has an outcome of a decreased volume of air expired from the lungs
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/forced+expiratory+volume
has_MedDRA_id: 10016987
see also: CTCAE: E12156
see also: NCIt: C50524

forearm fracture AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of fracture located in the arm
definition editor: DJ, SS, YH
has_MedDRA_id: 10016997

fracture AE
type: Class
subclass of: bone AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a bone disorder AE that has an outcome of complete or incomplete break in a bone resulting from the application of excessive force
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Fractures
has_MedDRA_id: 10017076
see also: CTCAE: E11703
see also: NCIt: C3046

full blood count decreased AE
type: Class
subclass of: full blood count abnormal AE
definition: a full blood count abnormal AE that has an outcome of a decrease in full blood cell count
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/full+blood+count
has_MedDRA_id: 10017413

fungal esophagitis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of inflammation in the esophagus due to fungus
definition editor: DJ, SS, YH
alternative term: fungal oesophagitis AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/
has_MedDRA_id: 10049656

gallbladder enlargement AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002110
definition: a digestive system AE that has an outcome of an abnormal enlargement in the size of the gallbladder
definition editor: DJ, SS, YH
has_MedDRA_id: 10062693

gallbladder perforation AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002110
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE that has an outcome of an abnormal hole in the patient's gallbladder
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/gallbladder+perforation
has_MedDRA_id: 10017639
see also: CTCAE: E11208
see also: NCIt: C78309

gallbladder polyp AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002110
definition: a digestive system AE that has an outcome of an abnormal growth (accumulation of mucous membrane tissue) in the gallbladder
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19556839
has_MedDRA_id: 10049704

gallop rhythm present AE
type: Class
subclass of: arrhythmia AE
definition: an arrhythmia AE that results in an abnormal heart sound
definition editor: DJ, SS, YH
definition source: WEB: http://circ.ahajournals.org/content/20/6/1053.full.pdf
has_MedDRA_id: 10017648

gamma-glutamyltransferase level abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a liver related investigation result abnormal AE that has an outcome of an abnormal level of gamma-glutamyltransferase (GGT); GGT is involved in the transfer of amino acids across the cellular membrane
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003458.htm
has_MedDRA_id: 10017688

gamma-glutamyltransferase level increased AE
type: Class
subclass of: gamma-glutamyltransferase level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a gamma-glutamyltransferase level abnormal AE that has an outcome of an increase in gamma-glutamyltransferase enzyme presence in the liver
definition editor: DJ, SS, YH, EB
alternative term: GGT increased
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23258530
has_MedDRA_id: 10017693
has_MedDRA_id: 10056910
see also: CTCAE: E12161
see also: NCIt: C26943

gastric cancer AE
type: Class
subclass of: gastric disorder AE
definition: a gastric disorder AE that has an outcome of cancer that starts in the stomach
definition editor: DJ, SS, YH
has_MedDRA_id: 10017758
see also: HPO: HP_0006753
see also: SIDER: C0024623

gastric neoplasm AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000945
definition: a tumor AE that has an outcome of cancer in the stomach
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/stomach+cancer
has_MedDRA_id: 10061968

gastric ulcer AE
type: Class
subclass of: gastric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a gastric disorder AE that has an outcome of a defect in the lining of the stomach
definition editor: DJ, SS, YH
alternative term: 胃溃疡
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
has_MedDRA_id: 10017822
see also: CTCAE: E10727
see also: HPO: HP_0002592
see also: NCIt: C3388
see also: SIDER: C0038358

gastritis AE
type: Class
subclass of: gastric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a gastric disorder AE that has an outcome of inflammation in the lining of the stomach
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002135/
has_MedDRA_id: 10017853
see also: CTCAE: E10733
see also: HPO: HP_0005263
see also: NCIt: C26780
see also: SIDER: C0017152

gastritis atrophic AE
type: Class
subclass of: gastritis AE
definition: a gastritis AE that has an outcome of inflammation in the stomach mucosa
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/2789800
has_MedDRA_id: 10017860

gastritis erosive AE
type: Class
subclass of: gastritis AE
definition: a gastritis AE that has an outcome of gastric mucosal erosion caused by damage to mucosal defences
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/gastritis
has_MedDRA_id: 10017865
see also: HPO: HP_0005263
see also: SIDER: C2243088

ischemic colitis AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000059
definition: ischemic colitis AE is a gastrointestinal disorder AE that results in injury and inflammation of the large intestine due to inadequate blood supply.
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Ischemic_colitis
has_MedDRA_id: 10009896

gastroenteritis norovirus AE
type: Class
subclass of: gastroenteritis AE
definition: a gastroenteritis AE that has an outcome of disease caused by the norovirus
definition editor: DJ, SS, YH
definition source: WEB: http://www.cdc.gov/ncidod/dvrd/revb/gastro/faq.htm
has_MedDRA_id: 10068189

gastroenteritis radiation AE
type: Class
subclass of: gastroenteritis AE
definition: a gastroenteritis AE that has an outcome of disease due to radiation
definition editor: DJ, SS, YH
has_MedDRA_id: 10017912

gastroesophageal reflux disease AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a digestive system AE that results in mucosal damage caused by acid from stomach coming up to the esophagus
definition editor: DJ, SS, YH
alternative term: GERD AE
alternative term: esophageal reflux AE
alternative term: gastrooesophageal reflux disease AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301861
has_MedDRA_id: 10017885
has_MedDRA_id: 10066874
see also: CTCAE: E10739
see also: NCIt: C26781

gastrointestinal infection AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disorder AE with an outcome of infection in the digestive tract caused by bacteria, viruses or parasites
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Gastrointestinal+infection
has_MedDRA_id: 10017964
see also: HPO: HP_0004798
see also: SIDER: C1264613

gastrointestinal injury AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disoder AE that has an outcome of an injury in the gastrointestinal area
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23207874
has_MedDRA_id: 10061172

gastrointestinal necrosis AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disoder AE that has an outcome of premature death in cells of living tissue in the stomach and intestines
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/necrosis
has_MedDRA_id: 10017982

bupropion-induced adverse event
type: Class
subclass of: causal adverse drug event
definition: an adverse event induced by administration of a bupropion drug
definition editor: YH

gastrointestinal perforation AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disorder AE that results in a hole in the wall of the esophagus, stomch, small intestine, large bowel, rectum or gallbladder
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/
has_MedDRA_id: 10018001
see also: HPO: HP_0011024
see also: SIDER: C0151664

gastrointestinal stromal tumor AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0005409
definition: a tumor AE that has an outcome of a tumor in the gastrointestinal tract, thought to grow from specialized cells found in the tract called interstitial cells of Cajal
definition editor: DJ, SS, YH
alternative term: gastrointestinal stromal tumour AE
definition source: WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor
has_MedDRA_id: 10051066
see also: HPO: HP_0007378
see also: SIDER: C0238198

gastrointestinal toxicity AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disorder AE that has an outcome of poison affecting the stomach and/or intestinal tracts, often accompanied by abdominal pain, diarrhea and vomiting
definition editor: DJ, SS, YH
definition source: WEB: http://www.theodora.com/drugs/valcyte_tablets_roche_laboratories.html
has_MedDRA_id: 10059024
see also: HPO: HP_0011024
see also: SIDER: C1142499

gene mutation identification test positive AE
type: Class
subclass of: cytogenetic investigation result abnormal AE
definition: a cytogenetic investigation result abnormal AE that has an outcome of a positive test for gene mutation, deletions and duplications that could indicate large disease risk
definition editor: DJ, SS, YH, EB
definition source: WEB: https://www.duchenneconnect.org/index.php?option=com_content&view=article&id=346&Itemid=392&lang=en
has_MedDRA_id: 10063478

general physical health deterioration AE
type: Class
subclass of: systematic AE
definition: a systematic adverse event that has an outcome of worsening of physical health
definition editor: DJ, SS, YH
has_MedDRA_id: 10049438

generalized edema AE
type: Class
subclass of: edema AE
definition: an edema AE that has an outcome of edema where causes of edema are generalized to the whole body, can cause edema in multiple organs and peripherally
definition editor: DJ, SS, YH
alternative term: generalised oedema AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/16491771
has_MedDRA_id: 10018092
see also: HPO: HP_0007430
see also: SIDER: C0151603

genital ulceration AE
type: Class
subclass of: skin ulceration AE
definition: a skin ulcer AE that results in an ulcer in the genital area usually resulting from an STD
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23064541
has_MedDRA_id: 10018180
see also: HPO: HP_0003249
see also: SIDER: C0151281

gingival abscess AE
type: Class
subclass of: abscess AE
definition: an abscess AE that has an outcome of a gum-line of the teeth due to pus-filled sacs
definition editor: DJ, SS, YH
definition source: WEB: http://www.mdguidelines.com/gingival-abscess
has_MedDRA_id: 10052359

gingival swelling AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of abnormally enlarged, bulging or protruding gums
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003066.htm
has_MedDRA_id: 10018291

glomerular filtration rate decreased AE
type: Class
subclass of: kidney AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000074
definition: a kidney disorder AE that has an outcome of a decreased rate per minute at which the blood passes through the glomeruli or the filters in the kidneys
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007305.htm
has_MedDRA_id: 10018358
see also: HPO: HP_0000083
see also: SIDER: C0853068

glossodynia AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of a burning or tingling sensation on the lips, tongue or entire mouth
definition editor: DJ, SS, YH
alternative term: burning tongue AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/glossodynia
has_MedDRA_id: 10018388
see also: HPO: HP_0000157
see also: SIDER: C0017672

glycosylated hemoglobin level decreased AE
type: Class
subclass of: glycosylated hemoglobin level abnormal AE
definition: a glycosylated hemoglobin level abnormal AE that has an outcome of decreased levels of glycosylated hemoglobin in the blood
definition editor: DJ, SS, YH, EB
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23015148
has_MedDRA_id: 10018482

belief in likelihood of causal connection between two processes
type: Class
subclass of: hypothesis textual entity
definition: a hypothesis textual entity that represents a belief in likelihood of causal connection between process 1 and process 2.
definition editor: Barry Smith, Yu Lin, Oliver He

graft infection AE
type: Class
subclass of: infection AE
definition: an infection AE that results in a graft infection
definition editor: DJ, SS, YH
has_MedDRA_id: 10056559

distal sensorimotor painful neuropathy
type: Class
subclass of: sensorimotor painful neuropathy AE
definition: a sensorimotor painful neuropathy AE which has an outcome of distal sensory neuropathy characterized by damage to sensory and motor nerves

gram stain positive AE
type: Class
subclass of: microbiology and serology investigation result abnormal AE
definition: a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-positive bacteria
definition editor: DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/gram+stain
has_MedDRA_id: 10018656

grand mal convulsion AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that results in a generalized seizure that affects the entire brain
definition editor: DJ, SS, YH, SJ
alternative term: tonic seizure
definition source: WEB: http://www.mayoclinic.com/health/grand-mal-seizure/DS00222
has_MedDRA_id: 10018659
see also: HPO: HP_0002197
see also: SIDER: C0014549

granulocyte count decreased AE
type: Class
subclass of: granulocyte count abnormal AE
definition: a granulocyte count abnormal AE that has an outcome of compromise to the immune system where the number of neutrophil granulocytes, a type of white blood cell, is lower than the normal range of ~1700 per microliter.
definition editor: DJ, SS, YH, EB
alternative term: neutropenia AE
has_MedDRA_id: 10018681

belief in likelihood of causal connection between medical intervention and adverse event
type: Class
subclass of: belief in likelihood of causal connection between two processes
definition: a belief in likelihood of causal connection between two processes that represents a belief in likelihood of causal connection between medical intervention m and adverse event e.
definition editor: Barry Smith, Yu Lin, Oliver He

granulocytopenia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of a marked decrease in number of granulocytes, a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms
definition editor: DJ, SS, YH
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=8817
has_MedDRA_id: 10018687

guttate psoriasis AE
type: Class
subclass of: psoriasis AE
definition: a psorisis AE that has an outcome of psoriasis that appears on the back and extremities of the patients
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/20860740
has_MedDRA_id: 10018797

adverse effect
type: Class
subclass of: disposition
definition: a disposition that represents the likelihood of the occurrence of an adverse event after a medical intervention.
definition editor: YH
alternative term: adverse side effect

gynaecomastia AE
type: Class
subclass of: male reproductive system AE
definition: a male reproductive system AE that has an outcome of abnormal development of large mammary glands in males resulting in breast enlargement
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/gynecomastia
has_MedDRA_id: 10018800
see also: HPO: HP_0000771
see also: SIDER: C0018418

adverse event causality evidence
type: Class
subclass of: information content entity
definition: an information content entity that represents evidence for indicating the causal association between an adverse event and a medical intervention.
definition editor: YH
alternative term: evidence bearing on adverse event causality

hematemesis AE
type: Class
subclass of: vomiting AE
definition: a vomiting AE that results in the vomiting of blood
definition editor: DJ, SS, YH
alternative term: haematemesis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hematemesis
has_MedDRA_id: 10018830
see also: HPO: HP_0002248
see also: SIDER: C0018926

hematochezia AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of the passage of bloody stools
definition editor: DJ, SS, YH
alternative term: haematochezia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hematochezia
has_MedDRA_id: 10018836
see also: HPO: HP_0002573
see also: SIDER: C0018932

hematocrit decreased AE
type: Class
subclass of: hematocrit abnormal AE
definition: a hematocrit abnormal AE with an outcome of decreased volume percentage of red blood cells in blood
definition editor: DJ, SS, YH, EB
alternative term: haematocrit decreased AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hematocrit
has_MedDRA_id: 10018838

hematoma infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000178
definition: an infection AE that has an outcome of infection in a hematoma
definition editor: DJ, SS, YH
alternative term: haematoma infection AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hematoma
has_MedDRA_id: 10051564

hematotoxicity AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of toxins that destroy red blood cells, disrupt blood clotting, and/or cause organ degeneration and generalized tissue damage
definition editor: DJ, SS, YH
alternative term: haematotoxicity AE
has_MedDRA_id: 10061188

bundle branch block left AE
type: Class
subclass of: conduction system disorder AE
definition: A conduction system disorder AE that is a condition in which ventricular contraction is not completely synchronized due to a block in conduction of an electrical impulse to the ventricles; in LBBB, right ventricular endocardial activation begins before, and is often completed before, initiation of left ventricular endocardial activation; benign LBBB is rare; preexisting LBBB in absence of clinical evidence of heart disease is rare; newly acquired LBBB has a 10-fold ↑ in mortality Clinical Generally asymptomatic, or absent or diminished 1st heart sound–HS and reversed splitting of 2nd HS EKG Lead V1–QS or rS; lead V6–late intrinsicoid deflection, monophasic R; lead I–monophasic R Management Pacemaker, if syncope or significant arrhythmias Followup Telemetry PRN.
definition editor: YH, SS
alternative term: LBBB
alternative term: left bundle branch block
definition source: WEB: http://medical-dictionary.thefreedictionary.com/left+bundle+branch+block
has_MedDRA_id: 10006580
see also: HPO: HP_0011713
see also: SIDER: C0023211

hemoglobin level abnormal AE
type: Class
subclass of: red blood cell profile abnormal AE
definition: a red blood cell profile abnormal AE that has an outcome of an abnormal count of hemoglobin, or iron-containing oxygen-transport metalloprotein in red blood cells
definition editor: DJ, SS, YH, EB
alternative term: haemoglobin abnormal AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin
has_MedDRA_id: 10018879

influenza vaccine administration
type: Class
subclass of: VO_0000002
definition: a vaccination that uses an influenza vaccine
definition editor: YH

adverse drug effect
type: Class
subclass of: adverse effect
definition: an adverse effect that occurs after a drug administration: an appreciably harmful or unpleasant reaction resulting from an intervention related to the use of a medicinal product
definition editor: YH, SJ
definition source: http://www.ncbi.nlm.nih.gov/pubmed/11072960
has_MedDRA_id: 10061623

hemolytic uremic syndrome AE
type: Class
subclass of: syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002390
definition: a hematopoietic system AE that has an outcome of hemolytic anemia, acute kidney failure and a low platelet count
definition editor: DJ, SS, YH
alternative term: haemolytic uraemic syndrome AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307876
has_MedDRA_id: 10018932
has_MedDRA_id: 10019515
see also: CTCAE: E10043
see also: HPO: HP_0005575
see also: NCIt: C75545
see also: SIDER: C0019061

hemoptysis AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of expectoration of blood or blood-stained sputum from the bronchi, larynx, trachea or lungs
definition editor: DJ, SS, YH
alternative term: haemoptysis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemoptysis
has_MedDRA_id: 10018964
see also: HPO: HP_0002105
see also: SIDER: C0019079

hemorrhage intracranial AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that has an outcome of accumulation of blood within the cranial vault
definition editor: DJ, SS, YH
alternative term: haemorrhage intracranial AE
definition source: WEB: http://emedicine.medscape.com/article/1163977-overview
has_MedDRA_id: 10018985
see also: HPO: HP_0002170
see also: SIDER: C0151699

hemorrhagic ovarian cyst AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that results in a 'blood cyst' where the walls of ovarian cysts are lined with blood vessels, which when rupture fill the cyst with blood.
definition editor: DJ, SS, YH
alternative term: haemorrhagic ovarian cyst AE
has_MedDRA_id: 10060781

haemorrhoid operation
type: Class
subclass of: surgery
definition: a surgery that removes hemorroids
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid
has_MedDRA_id: 10059624

outcome of adverse event causality evidence
type: Class
subclass of: information content entity
definition: an information content entity that represents the outcome of the evidences used for seeking the causal association between an adverse event and a medical intervention.
definition editor: YH

hemorrhoidal hemorrhage AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE that has an outcome of bleeding in hemorrhoids, vascular structures in the anal canal which help with stool control
definition editor: DJ, SS, YH
alternative term: haemorrhoidal haemorrhage AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid
has_MedDRA_id: 10054787
has_MedDRA_id: 10060640
see also: CTCAE: E10767
see also: NCIt: C78337

hemorrhoids AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a digestive system AE that has an outcome of painful, swollen veins in the lower portion of the rectum or anus
definition editor: DJ, SS, YH
alternative term: haemorrhoids AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001337/
has_MedDRA_id: 10019022
has_MedDRA_id: 10019611
see also: CTCAE: E10773
see also: HPO: HP_0004296
see also: NCIt: C26792

hemothorax AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of a collection of blood in the space between the chest wall and the lung
definition editor: DJ, SS, YH
alternative term: haemothorax AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001183/
has_MedDRA_id: 10019027

hair growth abnormal AE
type: Class
subclass of: hair AE
definition: a hair AE that has an outcome of abnormal growth of facial or body hair
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Hair+growth
has_MedDRA_id: 10019044
see also: HPO: HP_0010720
see also: SIDER: C0232409

adverse event causality score
type: Class
subclass of: data item
definition: an information content entity that represents a score or probability that an adverse event is likely caused (induced) by a medical intervention.
definition editor: YH
alternative term: adverse event causal association score
comment: adverse event causality assessment score

hemoglobin level decreased AE
type: Class
subclass of: hemoglobin level abnormal AE
definition: a hemoglobin level abnormal AE with an outcome of decrease in amount of iron-containing oxygen-transport metalloprotein in the red blood cells
definition editor: DJ, SS, YH, EB
alternative term: haemoglobin decreased AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin
has_MedDRA_id: 10018884

hepatic cirrhosis AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE that has an outcome of a chronic degenerative disease in which normal liver cells are damaged and then replaced by scar tissue
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Hepatic+cirrhosis
has_MedDRA_id: 10019641
see also: HPO: HP_0001394
see also: SIDER: C0023890

hepatic enzyme increased AE
type: Class
subclass of: hepatic enzyme abnormal AE
definition: a lab test abnormal AE that has an outcome of an increase in amount of hepatic enzyme in body, a liver/biliary system AE that has an outcome of elevated levels of liver enzymes, commonly ALT and AST, may indicate inflammation or damage to liver cells
definition editor: DJ, SS, YH
alternative term: elevated liver enzyme AE
definition source: WEB: http://www.mayoclinic.com/health/elevated-liver-enzymes/MY00508
has_MedDRA_id: 10060795
see also: HPO: HP_0002910
see also: SIDER: C0235996

hepatic failure AE
type: Class
subclass of: liver AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a liver/biliary system AE that has an outcome of the inability of the liver to perform its normal synthetic and metabolic function
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/liver+failure
has_MedDRA_id: 10019663
see also: CTCAE: E11211
see also: HPO: HP_0001399
see also: NCIt: C26922
see also: SIDER: C0085605

hepatic infarction AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE that results in incorrect blood flow to liver
definition editor: DJ, SS, YH
definition source: WEB: http://archinte.jamanetwork.com/article.aspx?articleid=571358
has_MedDRA_id: 10019680

adverse vaccine effect
type: Class
subclass of: adverse effect
definition: an adverse effect that occurs after administration of a vaccine.
definition editor: YH

hepatic lesion AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE with an outcome of a lesion, an abnormality in the tissue caused by disease or trauma, located in the liver
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21275132
has_MedDRA_id: 10061998

hepatic necrosis AE
type: Class
subclass of: liver AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: a liver/biliary system AE that has an outcome of death of hepatic parenchyma which may be single cell, or multicell in piecemeal, focal, periacinar, midzonal, periportal or paracentral locations
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hepatic+necrosis
has_MedDRA_id: 10019692
see also: CTCAE: E11221
see also: HPO: HP_0002605
see also: NCIt: C78340
see also: SIDER: C0151798

hepatic neoplasm AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002107
definition: a tumor AE that has an outcome of a malignant tumor in the liver
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23302476
has_MedDRA_id: 10019695
see also: HPO: HP_0002896
see also: SIDER: C0023903

acanthosis nigricans AE
type: Class
subclass of: skin AE
definition: Acanthosis nigricans AE is a skin AE that is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead, and other areas.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Acanthosis_nigricans
Chinese translation: 黑棘皮病
has_MedDRA_id: 10000350

hepatitis B AE
type: Class
subclass of: hepatitis viral AE
definition: a hepatitis AE that has an outcome of irritation and swelling of the liver due to infection with the heptitis B virus
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001324/
has_MedDRA_id: 10019731
see also: HPO: HP_0006562
see also: SIDER: C0019163

hepatitis viral AE
type: Class
subclass of: hepatitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hepatitis AE that has an outcome of liver inflammation due to a hepatitis viral infection
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis
has_MedDRA_id: 10019799
see also: CTCAE: E11410
see also: HPO: HP_0006562
see also: NCIt: C35124
see also: SIDER: C0042721

hepatomegaly AE
type: Class
subclass of: liver AE
definition: a liver/biliary system AE that has an outcome of swelling of the liver
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003275.htm
has_MedDRA_id: 10019842
see also: HPO: HP_0002240
see also: SIDER: C0019209

hepatotoxicity AE
type: Class
subclass of: liver damage AE
definition: a liver damage AE that has an outcome of chemically driven liver damage
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hepatotoxicity
has_MedDRA_id: 10019851

Afluria administration
type: Class
subclass of: influenza vaccine administration
definition: an influenza vaccine administration that uses Afluria
definition editor: YH

hidradenitis AE
type: Class
subclass of: inflammation AE
definition: an inflammation AE that has an outcome of an inflammatory infiltrate around the eccrine sweat gland
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hidradenitis
has_MedDRA_id: 10020040

histiocytosis hematophagic AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that has an outcome of abnormal proliferation of histiocytes, a type of immune cell that eats foreign substances
definition editor: DJ, SS, YH
alternative term: histiocytosis haematophagic AE
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=11478
has_MedDRA_id: 10048595

histoplasmosis disseminated AE
type: Class
subclass of: fungal infection AE
definition: a fungal infection AE that results in an infection that occurs from breathing in the spores of the fungus Histoplasma Capsulatum
definition editor: DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001082.htm
has_MedDRA_id: 10020144

caesarean section
type: Class
subclass of: surgery
definition: A surgery where incisions are made through a woman's abdomen and uterus to deliver her baby.
definition editor: YH, SS
alternative term: cesarean section
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cesarean+section
has_MedDRA_id: 10006924

hydronephrosis AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE that has an outcome of distension and dilation of the renal pelvis and calyces, usually caused by the osbtruction of urine flow from the kidney
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hydronephrosis
has_MedDRA_id: 10020524
see also: HPO: HP_0000126
see also: SIDER: C0020295

hyperbilirubinemia neonatal AE
type: Class
subclass of: congenital AE
definition: a congenital abnormality AE that results in the yellowing of the skin of infants
definition editor: DJ, SS, YH
alternative term: hyperbilirubinaemia neonatal AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/neonatal+jaundice
has_MedDRA_id: 10020580

hypercalcemia AE
type: Class
subclass of: blood calcium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood calcium increased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood calcium abnormal AE that has an outcome of an elevated calcium level in the blood, above normal range of 9-10.5 mg/dL
definition editor: YH, MW
alternative term: hypercalcaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypercalcemia
has_MedDRA_id: 10020583
has_MedDRA_id: 10020587
see also: CTCAE: E12270
see also: HPO: HP_0003072
see also: NCIt: C3112
see also: SIDER: C0020437

hyperhidrosis AE
type: Class
subclass of: sweating AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin AE that results in excess perspiration
definition editor: DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hyperhidrosis
has_MedDRA_id: 10020642
see also: HPO: HP_0000975
see also: SIDER: C0020458

hyperkalemia AE
type: Class
subclass of: blood potassium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood potassium increased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood potassium abnormal AE that has a lab test outcome of an abnormally increased concentration of potassium in blood
definition editor: YH, MW
alternative term: hyperkalaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia
has_MedDRA_id: 10020646
has_MedDRA_id: 10020647
see also: CTCAE: E12282
see also: HPO: HP_0002153
see also: NCIt: C37968
see also: SIDER: C0020461

toxin-induced cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE

cocaine-induced cardiomyopathy AE
type: Class
subclass of: toxin-induced cardiomyopathy AE

hyperparathyroidism secondary AE
type: Class
subclass of: abnormal fluid regulation AE
definition: an abnormal fluid regulation AE that has an outcome of an excessive secretion of the parathyroid hormone by the parathyroid gland
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23267748
has_MedDRA_id: 10020708
see also: HPO: HP_0003106
see also: SIDER: C0020503

paraparesis AE
type: Class
subclass of: paresis AE
definition: a paresis AE that shows muscle weakness affecting the lower limbs.
definition editor: JX, YH
definition source: WEB: http://www.merriam-webster.com/medical/paraparesis
Chinese translation: 下肢轻瘫
has_MedDRA_id: 10033885

hypertensive crisis AE
type: Class
subclass of: systemic hypertension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: a systemic hypertension AE that has an outcome of hypertension with systolic blood pressure >180 mm Hg or a diastolic pressure >120 mm, can be further classified as hypertensive urgency or hypertensive emergency depending on end-organ involvement
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/20160537
has_MedDRA_id: 10020802
see also: HPO: HP_0000875
see also: SIDER: C0020546

hypertriglyceridemia AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hematopoietic system AE that has an outcome of high blood levels of triglycerides, abundant fatty molecules
definition editor: DJ, SS, YH, MW
alternative term: hypertriglyceridaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypertriglyceridemia
has_MedDRA_id: 10020869
has_MedDRA_id: 10020870
see also: CTCAE: E12299
see also: HPO: HP_0002155
see also: NCIt: C37971
see also: SIDER: C0020557

hyperuricemia AE
type: Class
subclass of: arthritis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an arthritis AE that has an outcome of uric acid building up in blood and causes joint inflammation
definition editor: DJ, SS, YH, MW
alternative term: gout AE
alternative term: hyperuricaemia AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/
has_MedDRA_id: 10020903
has_MedDRA_id: 10020907
see also: CTCAE: E12305
see also: HPO: HP_0002149
see also: NCIt: C3961
see also: SIDER: C0740394

hypoalbuminemia AE
type: Class
subclass of: blood albumin abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood albumin abnormal AE that shows an abnormally low level of albumin protein in the blood.
definition editor: DJ, SS, YH
alternative term: hypoalbuminaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypoalbuminemia
has_MedDRA_id: 10020942
has_MedDRA_id: 10020943
see also: CTCAE: E12310
see also: HPO: HP_0003073
see also: NCIt: C37972
see also: SIDER: C0239981

hypocalcemia AE
type: Class
subclass of: blood calcium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood calcium decreased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood calcium abnormal AE that has an outcome of abnormally low calcium levels, can present with convulsions, arrythmias, tetany and numbness
definition editor: YH, MW
alternative term: hypocalcaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypocalcemia
Chinese translation: 低血钙
has_MedDRA_id: 10020947
has_MedDRA_id: 10020949
see also: CTCAE: E12316
see also: HPO: HP_0002901
see also: NCIt: C37973
see also: SIDER: C0020598

hypocapnia AE
type: Class
subclass of: blood carbon dioxide abnormal AE'
definition: a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally low.
definition editor: DJ, SS, YH, MW
definition source: WEB: https://en.wikipedia.org/wiki/Hypocapnia
has_MedDRA_id: 10020952
see also: UMLS CUI: C0085383

hypoglycemia AE
type: Class
subclass of: glucose homeostasis AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood glucose decreased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a glucose homeostasis AE that results in a abnormally diminished content of glucose in the blood
definition editor: DJ, SS, YH, MW
alternative term: hypoglycaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypoglycemia
has_MedDRA_id: 10020993
has_MedDRA_id: 10021005
see also: CTCAE: E12322
see also: HPO: HP_0005969
see also: NCIt: C3126
see also: SIDER: C0020615

Glascow coma scale abnormal AE
type: Class
subclass of: behavioral and neurological test abnormal AE
definition: a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of the recording of the level of consciousness in a person after a brain injuiry.
definition editor: YH, SJ
definition source: WEB: http://www.brainline.org/content/2010/10/what-is-the-glasgow-coma-scale.html
has_MedDRA_id: 10069709
comment: Clinicians use the Galscow coma scale to rate the best eye opening response, the best verbal response, and the best motor response an individual makes. The final GCS score or grade is the sum of these numbers.

hypomagnesemia AE
type: Class
subclass of: blood magnesium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood magnesium decreased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood magnesium abnormal AE that has an outcome of an abnormal concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors.
definition editor: YH, MW
alternative term: hypomagnesaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Hypomagnesaemia
has_MedDRA_id: 10021027
has_MedDRA_id: 10021028
see also: CTCAE: E12333
see also: HPO: HP_0002917
see also: NCIt: C37975
see also: SIDER: C0151723
see also: UMLS CUI: C0151723

intraventricular conduction delay AE
type: Class
subclass of: conduction system disorder AE
definition: a conduction system disorder AE that refers to the slow conduction of electricity through ventricular walls of the heart.
definition editor: SS
alternative term: IVCD
definition source: BOOK: Taber's Cyclopedic Medical Dictionary;2005, p1134 WEB: http://connection.ebscohost.com/c/reference-entries/21232773/intraventricular-conduction-delay

hypophagia AE
type: Class
subclass of: gustatory system AE
definition: a gustatory system AE with an outcome of reduced food intake
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypophagia
has_MedDRA_id: 10063743

hypophosphatemia AE
type: Class
subclass of: blood phosphate abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hematopoietic system AE that has an outcome of abnormally low phosphate levels, can present with muscle dysfunction, white cell dysfunction, pulp chambers and mental status changes
definition editor: DJ, SS, YH, MW
alternative term: hypophosphataemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypophosphatemia
has_MedDRA_id: 10021058
has_MedDRA_id: 10021059
see also: CTCAE: E12344
see also: HPO: HP_0008285
see also: NCIt: C37977
see also: SIDER: C0085682
see also: UMLS CUI: C0085682

hypothyroidism AE
type: Class
subclass of: endocrine system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002046
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an endocrine system AE with the outcome of the thyroid gland does not make enough thyroid hormone
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001393/
has_MedDRA_id: 10021114
see also: CTCAE: E10334
see also: HPO: HP_0008245
see also: NCIt: C26800
see also: SIDER: C0020676

hypovolemia AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that is characterized by decreased blood plasma volume
definition editor: DJ, SS, YH
alternative term: hypovolaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypovolemia
has_MedDRA_id: 10021137
see also: HPO: HP_0011106
see also: SIDER: C0546884

Flumist administration
type: Class
subclass of: influenza vaccine administration
definition: an influenza vaccine administration that uses Flumist
definition editor: YH

hypovolemic shock AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that has the outcome of severe blood and fluid loss that makes the heart unable to pump enough blood to the body, often leads to organ failure
definition editor: DJ, SS, YH
alternative term: hypovolaemic shock AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000167.htm
has_MedDRA_id: 10021138
see also: HPO: HP_0011106
see also: SIDER: C0020683

ileal perforation AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE that has an outcome of holes in the ileum of the small intestine
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/ileum
has_MedDRA_id: 10021305
see also: CTCAE: E10795
see also: NCIt: C78355

ileus AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE that has an outcome of a partially or completely blocked bowel
definition editor: DJ, SS, YH
alternative term: intestinal obstruction AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/
has_MedDRA_id: 10021328
see also: CTCAE: E10812
see also: HPO: HP_0002595
see also: NCIt: C37979
see also: SIDER: C1258215

ileus paralytic AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of intestinal blockage in the absence of an actual physical obstruction, can be caused by a malfunction in nerves and muscles in the intestine
definition editor: DJ, SS, YH
definition source: WEB: http://www.localhealth.com/article/paralytic-ileus
has_MedDRA_id: 10021333
see also: HPO: HP_0002590
see also: SIDER: C0030446

cardiomegaly AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: hypertension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac failure congestive AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac valve disease AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: A cardiac disorder AE that has an outcome of an abnormal enlargement of the heart
definition editor: YH, SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cardiomegaly
curator note: added MedDRA term LB
has_MedDRA_id: 10007632
see also: HPO: HP_0001640
see also: SIDER: C0018800

immunosuppressant drug level decreased AE
type: Class
subclass of: adverse drug event
definition: a drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Immunosuppresant
has_MedDRA_id: 10062014

immunosuppression AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that has an outcome of reduced or absent immune response
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001821/
has_MedDRA_id: 10062016

impaired healing AE
type: Class
subclass of: injury AE
definition: an injury AE that has an outcome of impairment to the process of restoring a state of soundness to any interupption in the continuity of external surfaces of the body
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/wound+healing
has_MedDRA_id: 10021519
see also: HPO: HP_0001058
see also: SIDER: C0151692

implant site pain AE
type: Class
subclass of: pain AE
definition: a pain AE that has an outcome of pain at the site of an implant
definition editor: DJ, SS, YH
has_MedDRA_id: 10063782

no evidence bearing on an adverse event causal relation
type: Class
subclass of: outcome of adverse event causality evidence
definition: an outcome of adverse event causality evidence that has an outcome of no evidence bearing on a AE causal relation.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.

increased viscosity of bronchial secretion AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of increased thickness of the secretions of the bronchi
definition editor: DJ, SS, YH
has_MedDRA_id: 10054761

infection parasitic AE
type: Class
subclass of: infection AE
definition: an infection AE that results in infection by a parasite
definition editor: DJ, SS, YH
has_MedDRA_id: 10021857
see also: HPO: HP_0002719
see also: SIDER: C0747256

infection susceptibility increased AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that has an outcome of increased susceptibility to infection
definition editor: DJ, SS, YH
has_MedDRA_id: 10021866
see also: HPO: HP_0002719
see also: SIDER: C0236171

infective pulmonary exacerbation of cystic fibrosis AE
type: Class
subclass of: infection AE
definition: an infection AE that has an outcome of an increase in severity of cystic fibrosis in the patient
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10070608

preventive intervention
type: Class
subclass of: medical intervention
definition: a medical intervention that is used for preventive purpose
definition editor: YH

infusion related reaction AE
type: Class
subclass of: immune system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a immune system AE that results in an allergic reaction to foreign protein, but can also be caused by cytokine release.
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ons.org/Publications/VJC/media/ons/docs/publications/VJC/vjc-apr10cjon.pdf
has_MedDRA_id: 10051792
has_MedDRA_id: 10053483
see also: CTCAE: E11127
see also: NCIt: C78361

infusion site extravasation AE
type: Class
subclass of: abnormal fluid regulation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an extravasation AE that has an outcome of leaking of pharmacologic or biological substance from infusion site into surrounding tissue. Symptoms include induration, erythema, swelling, burning sensation and pain
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/extravasation
has_MedDRA_id: 10064774
see also: CTCAE: E11133
see also: NCIt: C78362

infusion site infection AE
type: Class
subclass of: infection AE
definition: Infection AE that results in the patient gets infected at the sight of an infusion
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10054997

infusion site rash AE
type: Class
subclass of: rash AE
definition: Rash AE that results in patient has a rash at the site of infusion
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10059830

infusion site reaction AE
type: Class
subclass of: allergy AE
definition: an allergy AE that has an outcome of infusion site allergic reaction
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10054996

ingrowing nail AE
type: Class
subclass of: nail AE
definition: a nail disorder AE that results in a nail growing into the sides of the paronychium
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/ingrowing+nail
has_MedDRA_id: 10022013

injection-site macule AE
type: Class
subclass of: skin discoloration AE
definition: a skin discoloration AE that results in a discoloration of the skin at the site of injection of the drug
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/macule
has_MedDRA_id: 10067255

injection-site phlebitis AE
type: Class
subclass of: inflammation AE
definition: Inflammation AE that results in swelling of the veins at the site of drug injection
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/phlebitis
has_MedDRA_id: 10022090

cataract operation
type: Class
subclass of: surgery
definition: A surgery that is a procedure to remove the lens of your eye and, in most cases, replace it with an artificial lens. Cataract surgery is used to treat a cataract
definition editor: YH, SS
alternative term: cataract surgery
has_MedDRA_id: 10063797

injection-site scab AE
type: Class
subclass of: injection-site AE
subclass of: skin AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: an adverse event that results in the patient developing a scab at the site of drug injection
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10066210

instillation site pain AE
type: Class
subclass of: pain AE
definition: a pain AE that results in pain at the site of instillation
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/instillation
has_MedDRA_id: 10022459

intention tremor AE
type: Class
subclass of: tremor AE
definition: a tremor AE that results in the patient undergoing a broad, coarse, low frequency muscle tremor
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23094990
has_MedDRA_id: 10022520
see also: HPO: HP_0002345
see also: SIDER: C0234376

intentional drug misuse AE
type: Class
subclass of: adverse drug event
definition: an adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc)
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10065679

intentional overdose AE
type: Class
subclass of: incorrect drug dose administration
definition: an incorrect dose administration AE that results in overdosing on the drug on purpose
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10022523

interstitial lung disease AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000114
definition: a lung disorder AE that has an outcome of a disease affecting the interstitium, the tissue and space around the air sacs of the lungs
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23289473
has_MedDRA_id: 10022611
see also: HPO: HP_0006530
see also: SIDER: C0206062

intervertebral disc protrusion AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of the protrusion of the nucleus pulposus or anulus fibrosus of the intervertebral disk, which may impinge on nerve roots
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/herniation+of+intervertebral+disk
has_MedDRA_id: 10050296

intestinal ischemia AE
type: Class
subclass of: ischemia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000160
definition: an ischaemia AE that has an outcome of blocked or narrowed blood vessels to the small or large intestines, can cause pain and permanent damage to the intestines
definition editor: SZ, DJ, SS, YH
alternative term: intestinal ischaemia AE
has_MedDRA_id: 10022680

intestinal obstruction AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000160
definition: a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/
has_MedDRA_id: 10022687
see also: HPO: HP_0005250
see also: SIDER: C0021843

intestinal perforation AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000160
definition: a gastrointestinal disorder AE that has an outcome of perforation, or complete penetration, of the wall of the intestines
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/
has_MedDRA_id: 10022694

intracardiac thrombus AE
type: Class
subclass of: OAE_0004574
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
definition: a thrombosis AE that has an outcome of thrombi in the ventricles
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.cvimaging.northwestern.edu/for-physicians/cardiovascular-mri/indications/intracardiac-thrombus/
has_MedDRA_id: 10048620

intracranial pressure increased AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that has an outcome of a rise in the pressure inside the skull that can result from or cause brain injury
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000793.htm
has_MedDRA_id: 10022773
see also: HPO: HP_0002516
see also: SIDER: C0151740

intraocular pressure test result abnormal AE
type: Class
subclass of: behavioral and neurological test abnormal AE
definition: a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal intraocular pressure in the eye
definition editor: SZ, DJ, SS, YH, EB
has_MedDRA_id: 10060951

intussusception AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disorder AE that results in part of the intestine invaginating itself into another part of the intestine
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000958.htm
has_MedDRA_id: 10022863
comment: According to the Vaccine Adverse Event Reporting System (VAERS), 'intussusception'; is an adverse event that was mentioned in 143 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
see also: HPO: HP_0002576
see also: MP: MP_0003294
see also: SIDER: C0021933

iron deficiency anemia AE
type: Class
subclass of: anemia AE
definition: an anemia AE that has an outcome of fewer healthy red blood cells because the body does not have enough iron
definition editor: SZ, DJ, SS, YH
alternative term: iron deficiency anaemia AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000584.htm
has_MedDRA_id: 10022972
see also: HPO: HP_0001891
see also: SIDER: C0162316

irritability AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Behavior and Neurological AE that results in the patient being easily annoyed/irritated
definition editor: SZ, DJ, SS, YH
alternative term: feverish (subjective) AE
has_MedDRA_id: 10022998
see also: CTCAE: E11144
see also: HPO: HP_0000737
see also: NCIt: C50623
see also: SIDER: C0022107

jaundice cholestatic AE
type: Class
subclass of: jaundice AE
definition: a jaundice AE that results in an abnormal bile flow in the liver
definition editor: SZ, DJ, SS, YH
alternative term: cholestasis jaundice AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cholestatic+jaundice
has_MedDRA_id: 10023129
see also: HPO: HP_0006575
see also: SIDER: C0022354

jaw disorder AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of disease in the set of bones that hold the teeth
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/jawinjuriesanddisorders.html
has_MedDRA_id: 10061257

jaw fracture AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of break in the jaw bone
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000019.htm
has_MedDRA_id: 10023149

jugular vein thrombosis AE
type: Class
subclass of: venous thrombosis AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0004711
definition: a thrombosis AE with an outcome of formation of a blood clot located in the internal jugular vein
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10023237

klebsiella infection AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE with an outcome of invasion by Klebsiella pneumonia, a form of bacterial pneumonia
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/17307769
has_MedDRA_id: 10061259
see also: HPO: HP_0002742
see also: SIDER: C0022729

knee deformity AE
type: Class
subclass of: bone AE
definition: a bone disorder a that results in the knee becoming deformed
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10062061

lack of spontaneous speech AE
type: Class
subclass of: speech disorder AE
definition: a speech disorder AE that results in the inability of a patient to speak properly
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10023615

large for dates baby AE
type: Class
subclass of: congenital AE
definition: a congetical abnormality AE that results in the patient's baby being larger than it should be at the time in their pregnancy
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10023789

large granular lymphocytosis AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that has an outcome of an increase in the number or proportion of natural killer cells, or cytotoxic lymphocytes critical to the innate immune system
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/10761014
has_MedDRA_id: 10023791

large intestinal ulcer AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000059
definition: a gastrointestinal disorder AE that has an outcome of an ulcer in the large intestine
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Intestinal+ulcer
has_MedDRA_id: 10023799

large intestine perforation AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of perforation, or complete penetration, of the walls of the large intestine
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000235.htm
has_MedDRA_id: 10023804
see also: HPO: HP_0002250
see also: SIDER: NA

le cells present AE
type: Class
subclass of: immunology and allergy investigation result abnormal AE
definition: an immunology and allergy investigation result abnormal that results in LE cells (neutrophil or macrophage that has phagocytized the denatured nuclear material of another cell) being detected
definition editor: SZ, DJ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/LE+cell
has_MedDRA_id: 10024062

left atrial dilatation AE
type: Class
subclass of: dilatation atrial AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002079
definition: a dilatation atrial AE that results in the left atrium of the heart becoming enlarged
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096293/
has_MedDRA_id: 10067286

left ventricular dysfunction AE
type: Class
subclass of: cardiac ventricular disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002084
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiac ventricular disorder AE that has an outcome of inability of the left ventricle to pump blood, may lead to heart failure
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766527/
has_MedDRA_id: 10049694
see also: CTCAE: E10130
see also: NCIt: C64251

left ventricular failure AE
type: Class
subclass of: left ventricular dysfunction AE
definition: a left ventricular dysfunction AE that has an outcome of congestive heart failure marked by pulmonary congestion and edema, the left ventricle fals to contract forcefully enough to maintain normal cardiac output and peripheral perfusion
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/left+ventricular+failure
has_MedDRA_id: 10024119
see also: HPO: HP_0001635
see also: SIDER: C0023212

left ventricular hypertrophy AE
type: Class
subclass of: left ventricular dysfunction AE
definition: a left ventricular dysfunction disorder AE that has an outcome of the thickening of the myocardium of the left ventricle of the heart
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/18030317
has_MedDRA_id: 10049773

leukemia recurrent AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by return of symptoms after remission
definition editor: SZ, DJ, SS, YH
alternative term: leukaemia recurrent AE
definition source: WEB: http://www.yourcancertoday.com/Cancers/Leukemia-Acute-Myeloid-Adult/53
has_MedDRA_id: 10062489

leukemic infiltration brain AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that has an outcome of cancerous white blood cells infiltrating the brain
definition editor: SZ, DJ, SS, YH
alternative term: leukaemic infiltration brain AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/1454121
has_MedDRA_id: 10064987

leukemoid reaction AE
type: Class
subclass of: immune system AE
definition: Immune system disorder AE that results in an increase in white blood cell count as a result of stress or infection
definition editor: SZ, DJ, SS, YH
alternative term: leukaemoid reaction AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000575.htm
has_MedDRA_id: 10024328
see also: HPO: HP_0001909
see also: SIDER: C0023501

evidence inadequate to accept or reject an adverse event causal relation
type: Class
subclass of: outcome of adverse event causality evidence
definition: an outcome of adverse event causality evidence that has an outcome of evidence is inadequate to accept or reject an adverse event causal relation
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.

leukocytoclastic vasculitis AE
type: Class
subclass of: vasculitis AE
definition: an vasculitis AE that has an outcome of fragmented cells, and debris in the blood vessels. May develop skin lesions, accompanied by arthralgia and fever
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/leukocytoclastic+vasculitis
Chinese translation: 白细胞破碎性血管炎
has_MedDRA_id: 10024377
see also: HPO: HP_0011944
see also: SIDER: C2973529

leukocyturia AE
type: Class
subclass of: urinary system AE
definition: Urinary system AE that results in white blood cells in the urine
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/leukocyturia
has_MedDRA_id: 10050791

leukoencephalopathy AE
type: Class
subclass of: encephalopathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an encephalopathy AE that has an outcome of brain white matter disease
definition editor: SZ, DJ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/leukoencephalopathy
has_MedDRA_id: 10024382
see also: HPO: HP_0002352
see also: SIDER: C0270612

leukopenia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of a lower than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154209/
has_MedDRA_id: 10024384
see also: HPO: HP_0001882
see also: SIDER: C0023530

libido disorder AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that results in a disorder in the patient's desire for sexual interaction
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695750/
has_MedDRA_id: 10061221

lichen planus AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of an itchy rash on the skin or in the mouth
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001870/
has_MedDRA_id: 10024429

lip erosion AE
type: Class
subclass of: OAE_0004299
definition: a skin erosion AE that results in the deterioration of the lip skin
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10051992

lipase increased AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a digestive system AE that has an outcome of an excess of lipase, a pancreatic enzyme, may indicate a problem related to pancreas
definition editor: SZ, DJ, SS, YH
alternative term: hyperlipasemia AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/15653991
has_MedDRA_id: 10024574
see also: CTCAE: E12185
see also: NCIt: C78435

central venous catheterisation
type: Class
subclass of: medical intervention
definition: A medical intervention that is a tube going into a vein in your chest. It will help carry nutrients and medicine into your body. It will also be used to take blood when you need to have blood tests.
definition editor: YH, SS
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/patientinstructions/000157.htm
has_MedDRA_id: 10053377

liver AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002107
subclass of: hepatobiliary or pancreatic AE
definition: Liver/biliary system AE that results in the disease of the liver
definition editor: SZ, DJ, SS, YH
alternative term: liver disorder
definition source: WEB: http://www.nlm.nih.gov/medlineplus/liverdiseases.html
has_MedDRA_id: 10024670
see also: HPO: HP_0006706
see also: SIDER: C0023895

local swelling AE
type: Class
subclass of: edema AE
definition: a localized edema AE that shows the outcome of swelling.
definition editor: SZ, DJ, SS, YH
has_MedDRA_id: 10024770

localized infection AE
type: Class
subclass of: infection AE
definition: an infection AE located in a certain area
definition editor: SZ, DJ, SS, YH
alternative term: localised infection AE
has_MedDRA_id: 10024774
see also: HPO: HP_0002719
see also: SIDER: C0016397

localised intraabdominal fluid collection AE
type: Class
subclass of: abnormal fluid regulation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition: Abnormal fluid regulation AE that results in a collection of fluid in the intraabdominal area
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/intra-abdominal
has_MedDRA_id: 10066768

localized edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an edema AE occuring in a specific region
definition editor: SZ, DJ, SS, YH
alternative term: localised edema AE
alternative term: localised oedema AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115975/
has_MedDRA_id: 10048961
has_MedDRA_id: 10062466
see also: CTCAE: E11148
see also: HPO: HP_0000969
see also: NCIt: C78437
see also: SIDER: C0013609

loss of proprioception AE
type: Class
subclass of: movement disorder AE
definition: a movement disorder AE that has an outcome of loss of the sense of the relative position of neighbouring parts of the body and strength of effort being employed in movement
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/8294975
has_MedDRA_id: 10057332

lower gastrointestinal hemorrhage AE
type: Class
subclass of: gastrointestinal hemorrhage AE
definition: a gastrointestinal hemorrhage AE that has an outcome of bleeding in the lower gastrointestinal tract
definition editor: SZ, DJ, SS, YH
alternative term: lower gastrointestinal haemorrhage AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003133.htm
has_MedDRA_id: 10050953
see also: HPO: HP_0002239
see also: SIDER: C0024050

lower respiratory tract infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001558
definition: an infection AE that has an outcome of infection in the lower respiratory tract, includes pneumonea as well as lung abscess and acute bronchitis
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/books/NBK8142/
has_MedDRA_id: 10024968
see also: HPO: HP_0002783
see also: SIDER: C0149725

lung consolidation AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of liquid filling a region of lung tissue, marked by induration of a normally aerated lung
definition editor: SZ, DJ, SS, YH
alternative term: pulmonary consolidation AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/consolidation
has_MedDRA_id: 10025080

lung infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002048
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an infection AE that has an outcome of infection in the lungs
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.livestrong.com/lung-infection/
has_MedDRA_id: 10061229
see also: CTCAE: E11444
see also: HPO: HP_0002783
see also: NCIt: C26873
see also: SIDER: C0876973

lung infiltration AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of an abnormal presence of granulomas, fluid, inflammatory exudates or cells in the lung tissue
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.blurtit.com/q840550.html
has_MedDRA_id: 10025102
see also: HPO: HP_0005828
see also: SIDER: C0235896

lung neoplasm AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002048
definition: a tumor AE that has an outcome of a malignant tumor in the lung
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Lung+neoplasm
has_MedDRA_id: 10062042
see also: HPO: HP_0100526
see also: SIDER: C0024121

lymphadenopathy AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that has an outcome of lymphadenopathy, which is a term meaning "disease of the lymph nodes" . It is generally a disease or inflammation of the lymph nodes, could be due to infection, auto-immune disease or malignancy
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/lymphadenopathy
has_MedDRA_id: 10025197
see also: HPO: HP_0002716
see also: SIDER: C0497156

lymphangiosis carcinomatosa AE
type: Class
subclass of: inflammation AE
definition: an inflammation AE occuring in the lymph vessels secondary to a malignancy
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/8930034
has_MedDRA_id: 10053132

lymphocyte count decreased AE
type: Class
subclass of: lymphocyte count abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a lymphocyte count abnormal AE that has an outcome of a decreased amount of lymphocytes in the blood, a type of white blood cell in the immune system
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm
has_MedDRA_id: 10025256
see also: CTCAE: E12190
see also: NCIt: C26823

lymphocyte percentage increased AE
type: Class
subclass of: lymphocyte percentage abnormal AE
definition: a lymphocyte percentage abnormal AE that results in an increase in the levels of lymphocytes in the blood
definition editor: SZ, SS, YH, EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm
has_MedDRA_id: 10052232

lymphocytic infiltration AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that results in lymphocytes being infiltrated by harmful substances
definition editor: SZ, SS, YH
definition source: WEB: http://emedicine.medscape.com/article/1098654-overview
has_MedDRA_id: 10062049

lymphocytosis AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that has an outcome of an increase in the number or proportion of lymphocytes in the blood
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/lymphocytosis
has_MedDRA_id: 10025280
see also: HPO: HP_0012141
see also: SIDER: C0024282

lymphoedema AE
type: Class
subclass of: edema AE
definition: an edema AE that has an outcome of localized fluid retention and tissue swelling caused by a compromised lymphatic system
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://emedicine.medscape.com/article/1087313-overview Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23073712
has_MedDRA_id: 10025282
see also: HPO: HP_0001004
see also: SIDER: C0024236

lymphopenia AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of reduction in the number of lymphocytes in the blood
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/lymphopenia
has_MedDRA_id: 10025327
see also: HPO: HP_0001888
see also: SIDER: C0024312

macular degeneration AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000054
definition: a eye disorder AE that has an outcome of cell death in the macula of the eye, destroying central vision
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/maculardegeneration.html
has_MedDRA_id: 10025409
see also: HPO: HP_0007673
see also: SIDER: C0024437

male orgasmic disorder AE
type: Class
subclass of: male reproductive system AE
definition: a male reproductive system disorder AE that results in the inability of the male to achieve an orgasm despite lengthy sexual contact
definition editor: SZ, SS, YH
definition source: WEB: http://www.minddisorders.com/Kau-Nu/Male-orgasmic-disorder.html#b
has_MedDRA_id: 10025513

malignant neoplasm progression AE
type: Class
subclass of: tumor AE
definition: a tumor AE that has an outcome of growth or proliferation of an abnormal mass of tissue
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19824467
has_MedDRA_id: 10061309

malignant pleural effusion AE
type: Class
subclass of: respiratory system AE
definition: an respiratory system AE that has an outcome of abnormal amount of fluid collecting between the layers of tissue lining the outside of the lung and wall of chest cavity, caused by cancer
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/11529302
has_MedDRA_id: 10026673

colectomy
type: Class
subclass of: surgery
definition: A surgery that is a surgical procedure to remove all or part of your colon.
definition editor: YH, SS
definition source: WEB: http://www.mayoclinic.com/health/colectomy/MY00141/METHOD=print
has_MedDRA_id: 10061778

mammoplasty
type: Class
subclass of: surgery
definition: a surgery that is performed to change the size of breasts
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/mammoplasty
has_MedDRA_id: 10068647

coronary artery disorder AE
type: Class
subclass of: arterial disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001621
definition: an arterial disorder AE that resuts in arteries that supply blood to heart muscle become hardened and narrowed.
definition editor: YH, SS
alternative term: coronary artery disese AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/coronaryarterydisease.html
has_MedDRA_id: 10011078
has_MedDRA_id: 10011082

marrow hyperplasia AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002371
definition: a hematopoietic system AE that has an outcome of bone marrow that contains an excess of blood cells
definition editor: SZ, SS, YH
definition source: WEB: http://www.mayoclinic.com/health/aplastic-anemia/DS00322/DSECTION=causes
has_MedDRA_id: 10026851

maternal drugs affecting fetus AE
type: Class
subclass of: perinatal AE
definition: a perinatal AE that results in the drugs being taken by the mother affecting unborn fetus in mother
definition editor: SZ, SS, YH
alternative term: maternal drugs affecting foetus AE
has_MedDRA_id: 10026923

mediastinal disorder AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: an adverse event that results in a problem in the mediastinum of the patient (undelineated group of structures in the thorax surrounded by loose connective tissue)
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Mediastinal+diseases
has_MedDRA_id: 10061280
see also: HPO: HP_0000765
see also: SIDER: C0025061

megacolon AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001155
definition: a digestive system AE that has an outcome of abnormal dilation of the colon, often accompanied by paralysis of the peristaltic movements of the bowel
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/megacolon
has_MedDRA_id: 10027110
see also: HPO: HP_0002251
see also: SIDER: C0025160

melena AE
type: Class
subclass of: abnormal defecation AE
definition: Abnormal defecation AE that results in black feces associated with gastrointestinal hemorrhage
definition editor: SZ, SS, YH
alternative term: melaena AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003130.htm
has_MedDRA_id: 10027141
see also: HPO: HP_0002249
see also: SIDER: C0025222

memory impairment AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Behavior and Neurological AE that results in the loss of memory
definition editor: SZ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/impaired+memory
has_MedDRA_id: 10027175
see also: HPO: HP_0002354
see also: SIDER: C0233794

meningitis aseptic AE
type: Class
subclass of: brain inflammation AE
definition: a brain inflammation AE that results in the layers lining the brain becoming inflamed, not due to pygonenic bacteria
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/aseptic+meningitis
has_MedDRA_id: 10027201
see also: HPO: HP_0001287
see also: SIDER: C0025290

menometrorrhagia AE
type: Class
subclass of: hematuria AE
definition: Hematuria AE that results in excessive uterine bleeding occurs irregularly and more frequently than normal
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/menometrorrhagia
has_MedDRA_id: 10027295
see also: HPO: HP_0100608
see also: SIDER: C0232943

menorrhagia AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Female Reproductive System AE that results in abnormally heavy and prolonged menstrual period
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0014910/
has_MedDRA_id: 10027313
see also: HPO: HP_0000132
see also: SIDER: C0025323

mental status changes AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that has an outcome of changes in mental status
definition editor: SZ, SS, YH, Izabela Birsanescu
definition source: WEB: http://www.medicinenet.com/altered_mental_status/symptoms.htm
has_MedDRA_id: 10048294
comment: A mental status change does not have to be a disorder or even an adverse event. It can be a good change, from a disorder status to a normal recovered status.

metabolic disorder AE
type: Class
subclass of: metabolism, endocrine or exocrine system AE
definition: a metabolism, endocrine, and exocrine system AE that has an outcome of abnormal chemical reactions in the body that disrupts a metabolic process
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/metabolicdisorders.html
has_MedDRA_id: 10058097

dilatation atrial AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac valve disease AE
definition: A cardiac disorder AE that has an outcome of enlargement of the heart
definition editor: YH, SS
alternative term: atrial dilatation, atrial enlargement
has_MedDRA_id: 10013002

metastasis to abdominal cavity AE
type: Class
subclass of: tumor AE
definition: an abdominal AE that shows the spreading of the cancer cells to the abdominal cavity of the patient
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/19373966
has_MedDRA_id: 10027450

metastasis to bone AE
type: Class
subclass of: tumor AE
definition: a tumor AE that has an outcome of cancerous cells spreading to the bone from elsewhere
definition editor: SZ, SS, YH
has_MedDRA_id: 10027452

metastasis to central nervous system AE
type: Class
subclass of: tumor AE
editor preferred label: a tumor AE that results in cancerous cells spreading from a primary tumor to the central nervous system
definition editor: SZ, SS, YH
definition source: WEB: http://theoncologist.alphamedpress.org/content/8/5/398.long, http://www.ncbi.nlm.nih.gov/pubmed/19373966
has_MedDRA_id: 10059282

metastasis to liver AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002107
definition: a tumor AE that results in cancerous cells spreading to the liver organ
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000277.htm
has_MedDRA_id: 10027457

metastasis to lung AE
type: Class
subclass of: tumor AE
definition: a tumor AE that results in cancerous cells spreading to the lung
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000097.htm
has_MedDRA_id: 10027458

metastasis to meninges AE
type: Class
subclass of: tumor AE
definition: a tumor AE that has an outcome cancerous cells spreaing from primary tumor to the thin layers of tissue that protect the brain and spinal cord, may experience increased intracranial pressure
definition editor: SZ, SS, YH
alternative term: meningeal metastasis AE
definition source: WEB: 1. http://theoncologist.alphamedpress.org/content/1/1/56.full 2. http://www.cancer.gov/dictionary?cdrid=45782
has_MedDRA_id: 10051696

metastasis to peritoneum AE
type: Class
subclass of: tumor AE
definition: a tumor AE that results in cancerous cells spreading from primary tumor to the lining of the abdominal cavity or the coelom.
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/peritoneum Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed?term=metastasis%20to%20peritoneum%20%5BTI%5D
has_MedDRA_id: 10051676

metastasis to pleura AE
type: Class
subclass of: tumor AE
definition: a tumor AE that results in a disease spreading to the pleural cavity due to cancerous activities
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/pleuraldisorders.html
has_MedDRA_id: 10027463

evidence favoring rejection of an adverse event causal relation
type: Class
subclass of: outcome of adverse event causality evidence
definition: an outcome of adverse event causality evidence that has an outcome of evidence favors rejection of an adverse event causal relation
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.

metastasis to spine AE
type: Class
subclass of: tumor AE
definition: a tumor AE that results in cancerous cells spreading to the spine
definition editor: SZ, SS, YH
definition source: WEB: http://emedicine.medscape.com/article/1157987-overview
has_MedDRA_id: 10027468

metastasis AE
type: Class
subclass of: tumor AE
definition: a tumor AE with an outcome of spreading of disease from one organ to another non-adjacent organ or part
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm
has_MedDRA_id: 10062194

metastatic neoplasm AE
type: Class
subclass of: tumor AE
definition: a tumor AE with an outcome of spreading of cancerous cells from abnormal mass of tissue
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/20121607
has_MedDRA_id: 10061289

metrorrhagia AE
type: Class
subclass of: urinary system AE
definition: Urinary System AE that is characterized by uterine bleeding at irregular intervals
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/metrorrhagia
has_MedDRA_id: 10027514
see also: HPO: HP_0100608
see also: SIDER: C0025874

microangiopathic hemolytic anemia AE
type: Class
subclass of: cardiovascular AE
definition: Cardiovascular disorder AE that results in a fragmentation of red blood cells resulting from the narrowing of small blood vessels
definition editor: SZ, SS, YH
alternative term: microangiopathic haemolytic anaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/microangiopathic+hemolytic+anemia
has_MedDRA_id: 10027527
see also: HPO: HP_0001937
see also: SIDER: C0221021

mitral valve incompetence AE
type: Class
subclass of: cardiac valve disease AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002135
definition: a cardiac valve disease AE that is characterized by the inability of the heart's mitral valve to close tightly, allowing blood to flow backward in the heart
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Mitral+Valve+Insufficiency
has_MedDRA_id: 10027727
see also: HPO: HP_0001653
see also: SIDER: C0026266

mouth hemorrhage AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: a digestive system AE that has an outcome of bleeding from blood vessels located in the mouth
definition editor: SZ, SS, YH
alternative term: mouth haemorrhage AE
definition source: WEB: http://sideeffects.embl.de/se/C0029163/
has_MedDRA_id: 10028024
see also: HPO: HP_0000167
see also: SIDER: C0029163

mouth ulceration AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: a digestive system AE that has an outcome of sores or open lesions in the mouth
definition editor: SZ, SS, YH
alternative term: aphthous stomatitis AE
alternative term: canker sore AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001448.htm
has_MedDRA_id: 10028034
see also: HPO: HP_0000155
see also: SIDER: C0149745

multiple sclerosis relapse AE
type: Class
subclass of: multiple sclerosis AE
definition: Multiple Sclerosis AE that is characterized by a relapse of Multiple Sclerosis
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001747/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22980532
has_MedDRA_id: 10048393

muscle cramp AE
type: Class
subclass of: muscle twitch AE
definition: a muscle contraction AE that has an outcome of painful sensations, associated with muscle fatigue and low sodium/potassium
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/musclecramps.html
has_MedDRA_id: 10028294

muscle enzyme level increased AE
type: Class
subclass of: muscle enzyme level abnormal AE
definition: a muscle enzyme level abnormal AE that results in an increased level of muscle enzyme
definition editor: SZ, SS, YH
has_MedDRA_id: 10057945

muscular dystrophy AE
type: Class
subclass of: muscle AE
definition: a muscle AE that results in the musculoskeletal system being weakened at locomotion is hampered
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002172/
has_MedDRA_id: 10028356

musculoskeletal chest pain AE
type: Class
subclass of: pain AE
definition: a pain AE located in musculoskeletal structures of the chest wall, atypical or noncardiac chest pain
definition editor: SZ, SS, YH
definition source: WEB: http://www.uptodate.com/contents/major-causes-of-musculoskeletal-chest-pain?source=see_link
has_MedDRA_id: 10050819
see also: HPO: HP_0006649
see also: SIDER: C0476280

mycoplasma infection AE
type: Class
subclass of: bacterial infection AE
definition: Bacterial infection AE that results in the patient being infected with the Mycoplasma bacteria
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/15142464
has_MedDRA_id: 10061300

evidence favoring acceptance of an adverse event causal relation
type: Class
subclass of: outcome of adverse event causality evidence
definition: an outcome of adverse event causality evidence that has an outcome of evidence favors acceptance of an adverse event causal relation
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.

myelodysplastic syndrome AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: a hematopoietic system AE that has an outcome of ineffective production of the myeloid class of blood cells
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.nlm.nih.gov/medlineplus/myelodysplasticsyndromes.html
has_MedDRA_id: 10028533
see also: HPO: HP_0006730
see also: SIDER: C0026986

myelofibrosis AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of bone marrow being replaced by scar tissue
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001558/
has_MedDRA_id: 10028537
see also: HPO: HP_0011974
see also: SIDER: C0026987

myocardial ischemia AE
type: Class
subclass of: ischemia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
definition: a cardiac disorder AE that has an outcome of an imbalance between myocardial oxygen supply and demand
definition editor: SZ, SS, YH
alternative term: myocardial ischaemia AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768241/
has_MedDRA_id: 10028600
see also: HPO: HP_0001637
see also: SIDER: C0151744

myocarditis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has an outcome of inflammation of the heart muscle
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001204/
has_MedDRA_id: 10028606
see also: CTCAE: E10157
see also: NCIt: C34831

nail disorder AE
type: Class
subclass of: bone AE
definition: a bone disorder AE, most commonly fungal infection, that is characterized by discoloration, painful swelling, pits, lesions and brown bands
definition editor: SZ, SS, YH
definition source: WEB: http://www.umm.edu/altmed/articles/nail-disorders-000116.htm
has_MedDRA_id: 10028694
see also: HPO: HP_0001597
see also: SIDER: C0027339

nail infection AE
type: Class
subclass of: nail AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a nail AE around the nail area, tends to be fungal
definition editor: SZ, SS, YH
definition source: WEB: http://www.emedicinehealth.com/paronychia_nail_infection/article_em.htm
has_MedDRA_id: 10061304
see also: HPO: HP_0008396
see also: SIDER: C0343026

necrosis ischemic AE
type: Class
subclass of: cell death AE
definition: Cell death AE that results in necrosis occurring due to a local deprivation of blood
definition editor: SZ, SS, YH
alternative term: necrosis ischaemic AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/ischemic+necrosis
has_MedDRA_id: 10028862

neoplasm malignant AE
type: Class
subclass of: tumor AE
definition: a progressive tumor AE that has an outcome of an abnormal mass of cells that metastasizes
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/malignant+neoplasm
has_MedDRA_id: 10028997
see also: HPO: HP_0002664
see also: SIDER: C0006826

neoplasm progression AE
type: Class
subclass of: tumor AE
definition: an tumor AE that has an outcome of growth of the neoplasm, an abnormal mass of tissue in the body
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/neoplasm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23263846
has_MedDRA_id: 10061309

neoplasm recurrence AE
type: Class
subclass of: tumor AE
definition: a tumor AE that has an outcome of microscopic cells of the original neoplasm escaping therapeutic intervention and later becoming clinically visible at the original site
definition editor: SZ, SS, YH
has_MedDRA_id: 10061864

nephrocalcinosis AE
type: Class
subclass of: kidney AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0008987
definition: Kidney disorder AE that results in an increased amount of calcium deposits in the renal parenchyma
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001522/
has_MedDRA_id: 10029146
see also: HPO: HP_0000121
see also: SIDER: C0027709

nephrotic syndrome AE
type: Class
subclass of: kidney AE
definition: a kidney disorder AE that has an outcome of a group of symptoms that include protein in the urine, low blood protein levels, high cholesterol levels, high triglyceride levels and swelling
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001520/
has_MedDRA_id: 10029164
see also: HPO: HP_0000100
see also: SIDER: C0027726

nerve compression AE
type: Class
subclass of: neuropathy AE
definition: a neuropathy AE that has an outcome of direct pressure on a single nerve, can cause pain, tingling and muscle weakness
definition editor: SZ, SS, YH
definition source: WEB: http://nerve.wustl.edu/nd_compression.php
has_MedDRA_id: 10029174

nerve root compression AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002211
definition: Nervous System AE that results in pressure on a root nerve
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/6719259
has_MedDRA_id: 10061866

nerve root lesion AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002211
definition: Nervous system AE that results in a lesion occurring on a nerve root
definition editor: SZ, SS, YH
has_MedDRA_id: 10029188

neurological decompensation AE
type: Class
subclass of: nervous system AE
definition: A nervous system AE that has an outcome of inability of maintaining neurological functions.
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/decompensation
has_MedDRA_id: 10068357

neuroma AE
type: Class
subclass of: tumor AE
definition: Tumor AE that results in a tumor growing on nerve tissue
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/neuroma
has_MedDRA_id: 10029308
see also: HPO: HP_0009588
see also: SIDER: C0027858

neurotoxicity AE
type: Class
subclass of: neuropathy AE
definition: a nervous system AE that alters the normal activity of the nervous system due to exposure to neurotoxins (which can be natural or artificial toxic substances), and causes damage to nervous tissue
definition editor: SZ, SS, YH, QL
alternative term: toxic neuropathy AE
definition source: WEB: http://en.wikipedia.org/wiki/Neurotoxicity
has_MedDRA_id: 10029350
has_MedDRA_id: 10067722

neutralizing antibodies positive AE
type: Class
subclass of: immunology and allergy investigation result abnormal AE
definition: an immunolgy and allergy investigation result abnormal AE that is chracterized by neutralising antibodies detected in the blood
definition editor: SZ, SS, YH, EB
alternative term: neutralising antibodies positive AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/neutralizing+antibody
has_MedDRA_id: 10064980

neutropenia AE
type: Class
subclass of: leukopenia AE
definition: a neutropenia AE that compromises the immune system where the number of neutrophil granulocytes, a type of white blood cell, is abnormally low. A neutropenia makes body vulnerable to bacterial and fungal infections.
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/neutropenia
has_MedDRA_id: 10029354
see also: HPO: HP_0001875
see also: SIDER: C0027947

neutropenia neonatal AE
type: Class
subclass of: neonatal AE
definition: a neutropenia AE that results in an abnormal number of neutrophils in a newborn infant
definition editor: SZ, SS, YH
definition source: WEB: http://www.thefreedictionary.com/neonatal, http://medical-dictionary.thefreedictionary.com/neonatal+neutropenia,+alloimmune
has_MedDRA_id: 10029358

neutropenic colitis AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000059
definition: a gastrointestinal Inflammation AE that results in the cecum, part of the large intestine, being inflamed
definition editor: SZ, SS, YH
definition source: WEB: http://emedicine.medscape.com/article/183791-overview
has_MedDRA_id: 10062959
see also: HPO: HP_0002583
see also: SIDER: C0400823

neutropenic sepsis AE
type: Class
subclass of: sepsis AE
definition: a sepsis AE caused by neutropenia or an abnormally low neutrophil count
definition editor: SZ, SS, YH
definition source: WEB: http://guidance.nice.org.uk/CG151
has_MedDRA_id: 10049151

neutrophil count abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that results in an abnormal number of neutrophil granulocytes, a type of white blood cell (outside the normal range of ~1700 per microliter)
definition editor: SZ, SS, YH, EB
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=20030
has_MedDRA_id: 10061313

neutrophil count decreased AE
type: Class
subclass of: neutrophil count abnormal AE
subclass of: Restriction
  on property: is evidence of
  some values from: neutropenia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a neutrophil count abnormal AE that has an outcome of decreased neutrophil count
definition editor: SZ, SS, YH, EB
alternative term: neutropenia AE
definition source: WEB: http://www.mayoclinic.com/health/neutropenia/MY00110
has_MedDRA_id: 10029366
see also: CTCAE: E12198
see also: HPO: HP_0011991
see also: NCIt: C80520
see also: SIDER: NA

neutrophil percentage increased AE
type: Class
subclass of: neutrophil percentage abnormal AE
definition: a neutrophil percentage abnormal AE that has an outcome of increase in percentage of neutrophils, a type of white blood cell
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/neutrophil
has_MedDRA_id: 10052224

nodular regenerative hyperplasia AE
type: Class
subclass of: hyperplasia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002107
definition: a hyperplasia AE that has an outcome of liver/biliary system cell overproduction, associated with portal hypertension
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070012/
has_MedDRA_id: 10051081

non-small cell lung cancer AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of adenocarcinomas in an outer area of the lung, squamous cell carcinomas in the center of the lung or large cell carcinomas in any part of the lung
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004462/
has_MedDRA_id: 10061873

non-small cell lung cancer stage iv AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that results in the patient suffering from lung cancer at state IV
definition editor: SZ, SS, YH
has_MedDRA_id: 10029522

normochromic normocytic anemia AE
type: Class
subclass of: anemia AE
definition: an anemia AE that has an outcome of insufficient numbers of red blood cells despite a normal concentration of hemoglobin in the cells
definition editor: SZ, SS, YH
alternative term: normochromic normocytic anaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/normocytic+normochromic+anemia
has_MedDRA_id: 10029783
see also: HPO: HP_0001897
see also: SIDER: C0271899

obesity surgery
type: Class
subclass of: surgery
definition: a surgery that aims to control obesity
definition editor: SZ, SS, YH
has_MedDRA_id: 10059610

obstructive airways disorder AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of chronic bronchitis or emphysema which causes the airways to narrow over time
definition editor: SZ, SS, YH
definition source: WEB: http://www.medicinenet.com/chronic_obstructive_pulmonary_disease_copd/article.htm
has_MedDRA_id: 10061877
see also: HPO: HP_0006536
see also: SIDER: C0600260

occult blood AE
type: Class
subclass of: gastrointestinal investigation result abnormal AE
definition: a gastrointestinal investigation result abnormal AE that results in blood that is present in amounts too small to be seen and can be detected only by chemical analysis or microscopic examination
definition editor: SZ, SS, YH, EB
definition source: WEB: http://dictionary.reference.com/browse/occult+blood
definition source: WEB: http://medical-dictionary.thefreedictionary.com/occult+blood\
has_MedDRA_id: 10061878

odynophagia AE
type: Class
subclass of: digestive system AE
definition: a gustatory system AE that has an outcome of painful swallowing in the mouth or esophagus. Can lead to weight loss.
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/odynophagia
has_MedDRA_id: 10030094

esophageal pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001043
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE located in the esophagus
definition editor: SZ, SS, YH
alternative term: oesophageal pain AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/oesophageal
has_MedDRA_id: 10015388
has_MedDRA_id: 10030180
see also: CTCAE: E10661
see also: HPO: HP_0010833
see also: NCIt: C78280
see also: SIDER: C0221727

esophageal stenosis AE
type: Class
subclass of: OAE_0004228
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001043
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an esophagus AE that results in a narrowing in the esophagus caused by buildup of scar tissue or by a congenital defect
definition editor: SZ, SS, YH
alternative term: oesophageal stenosis AE
definition source: WEB: http://esophagealstenosis.org/
has_MedDRA_id: 10015448
has_MedDRA_id: 10030194
see also: CTCAE: E10670
see also: HPO: HP_0010450
see also: NCIt: C34595
see also: SIDER: C0014866

esophagitis AE
type: Class
subclass of: OAE_0004228
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an esophagus AE located in the esophagus, can present with heartburn, and nausea
definition editor: SZ, SS, YH
alternative term: oesophagitis AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/
has_MedDRA_id: 10015461
has_MedDRA_id: 10030216
see also: CTCAE: E10687
see also: HPO: HP_0100633
see also: NCIt: C9224
see also: SIDER: C0014868

oligohydramnios AE
type: Class
subclass of: reproductive system AE
definition: a reproductive system AE that has an outcome of insufficient placenta, the baby may get less oxygen and nutrients
definition editor: SZ, SS, YH
alternative term: placental dysfunction AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002455/
has_MedDRA_id: 10030289
see also: HPO: HP_0001562
see also: SIDER: C0079924

onychalgia AE
type: Class
subclass of: nail AE
definition: a nail disorder AE that has an outcome of pain in the fingernails or toenails
definition editor: SZ, SS, YH
definition source: WEB: http://dictionary.reference.com/browse/onychalgia
has_MedDRA_id: 10064251

onychoclasis AE
type: Class
subclass of: nail AE
definition: a nail disorder AE that results in the breaking of the fingernails or toenails
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/onychoclasis
has_MedDRA_id: 10048886
see also: HPO: HP_0001808
see also: SIDER: C0546956

onycholysis AE
type: Class
subclass of: nail AE
definition: a nail disorder AE that results in the nail separating from the nail bed starting at distal or lateral attachment
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/16422468
has_MedDRA_id: 10030337
see also: HPO: HP_0008400
see also: SIDER: C0085661

evidence establishing an adverse event causal relation
type: Class
subclass of: outcome of adverse event causality evidence
definition: an outcome of adverse event causality evidence that has an outcome of evidence establishes an adverse event causal relation
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 33.

onychomadesis AE
type: Class
subclass of: nail AE
definition: a nail disorder AE that results in nails spontaneously shedding starting from the proximal end
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/onychomadesis
has_MedDRA_id: 10049274

open angle glaucoma AE
type: Class
subclass of: eye AE
definition: Eye disorder AE that results in chronic glaucoma progressing slowly
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002587/
has_MedDRA_id: 10030348
see also: HPO: HP_0000501
see also: SIDER: C0017612

opiates positive AE
type: Class
subclass of: toxicology drug screen result abnormal AE
definition: a toxicology drug screen result abnormal AE that results in the patient testing positive for opiates
definition editor: SZ, SS, YH, EB
has_MedDRA_id: 10063232

oral candidiasis AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: a digestive system AE that has an outcome of a fungal infection located in the mouth caused by the candida fungus
definition editor: SZ, SS, YH
alternative term: thrush AE
definition source: WEB: http://www.medicinenet.com/thrush/article.htm
has_MedDRA_id: 10030963
see also: HPO: HP_0009098
see also: SIDER: C0006849

oral cavity fistula AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a digestive system AE that has an outcome of fistula, or an abnormal connection between two epithelium-lined organs or vessels, located in the oral cavity
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/fistula
has_MedDRA_id: 10065720
see also: CTCAE: E10888
see also: NCIt: C78506

oral herpes AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: a digestive system AE that has an outcome of a viral infection located in the mouth caused by herpes simplex virus, causes painful sores
definition editor: SZ, SS, YH
definition source: WEB: http://www.emedicinehealth.com/oral_herpes/article_em.htm
has_MedDRA_id: 10067152

oral intake reduced AE
type: Class
subclass of: gustatory system AE
definition: a gustatory system AE that has an outcome of a decreased amount of substance in food or drinking water ingested
definition editor: SZ, SS, YH

oral mucosa erosion AE
type: Class
subclass of: digestive system AE
definition: Digestive System AE that results in oral lesions
definition editor: SZ, SS, YH
has_MedDRA_id: 10064594

oral mucosal erythema AE
type: Class
subclass of: erythema AE
definition: an erythema AE that results in redness of the oral mucosa area
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/17767983
has_MedDRA_id: 10067418

oral pain AE
type: Class
subclass of: pain AE
definition: a pain AE located in the oral cavity, pertaining to the mouth
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/oral
has_MedDRA_id: 10031009
see also: CTCAE: E10904
see also: HPO: HP_0010833
see also: NCIt: C78509
see also: SIDER: C0221776

oral soft tissue disorder AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: a digestive system AE that has an outcome of disease in the soft tissue of the mouth or systemic diseases involving the mouth
definition editor: SZ, SS, YH
definition source: WEB: http://clinicaltrials.gov/show/NCT00001601
has_MedDRA_id: 10031015

oral surgery
type: Class
subclass of: surgery
definition: a surgery that treats injuries and defects involving both the functional and esthetic aspects of the hard/soft tissue of the head, mouth, teeth, gums, jaws, and neck
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/oral+surgery Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22530364
has_MedDRA_id: 10051059

orbital edema AE
type: Class
subclass of: edema AE
definition: an edema that results in swelling around the eyes
definition editor: SZ, SS, YH
alternative term: orbital oedema AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/7654583
has_MedDRA_id: 10031051
see also: HPO: HP_0100539
see also: SIDER: C0424813

organizing pneumonia AE
type: Class
subclass of: pneumonia AE
definition: a pneumonia AE that results in the healing process being characterized by organization and cicatrizaion of the exudate rather than resolution
definition editor: SZ, SS, YH
alternative term: organising pneumonia AE
definition source: WEB: Primary Source: http://thorax.bmj.com/content/55/4/318.full Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745738/
has_MedDRA_id: 10067472
see also: HPO: HP_0002090
see also: SIDER: C0264383

oropharyngeal candidiasis AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001007
definition: Digestive System AE that is characterized by fungus (mainly Candida albicans, but can be other Candida species - C.glabrata, C. tropicalis, C. krusei) in throat or mouth (Thrush)
definition editor: SZ, SS, YH
definition source: WEB: http://www.cdc.gov/fungal/candidiasis/thrush/
has_MedDRA_id: 10050346
see also: HPO: HP_0009098
see also: SIDER: C0919659

oropharyngeal spasm AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of muscle spasm in the oropharynx area
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Oropharyngeal+airway
has_MedDRA_id: 10031111
see also: HPO: HP_0003739
see also: SIDER: C0234952

osteomyelitis AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of bacterial infection in the bone
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001473/
has_MedDRA_id: 10031252
see also: HPO: HP_0007626
see also: SIDER: C0029443

osteomyelitis chronic AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of chronic infection of the bone or bone marrow
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://www.posna.org/education/StudyGuide/chronicOsteomyelitis.asp Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/20471296
has_MedDRA_id: 10031256

adverse event relative risk
type: Class
subclass of: data item
definition: a data item that represents the ratio of the rate of occurence of the adverse event in persons having the medical intervention (e.g., vaccination) to the rate in otherwise comparable persons without the medical intervention.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20-21.

osteonecrosis AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of bone death due to the loss of blood supply, leading to pain and arthritis
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/osteonecrosis.html
has_MedDRA_id: 10031264
see also: HPO: HP_0010885
see also: SIDER: C0029445

osteonecrosis of jaw AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of disease that affects the maxilla and the mandible, characterized through exposure of the bone through lesions in the gingiva that do not heal
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/16702591
has_MedDRA_id: 10064658
see also: HPO: HP_0010885
see also: SIDER: C1401381

osteoradionecrosis AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of necrosis or death of bone as a result of exposure to radiation
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/osteoradionecrosis
has_MedDRA_id: 10067352

osteosclerosis AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of elevation in bone density
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/osteosclerosis
has_MedDRA_id: 10031298
see also: HPO: HP_0011001
see also: SIDER: C0029464

ovarian cancer AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that has an outcome of cancer that starts in the ovaries, female reproductive organs that produce eggs
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001891/
has_MedDRA_id: 10033128
see also: HPO: HP_0100615
see also: SIDER: C1140680

ovarian enlargement AE
type: Class
subclass of: female reproductive system AE
definition: Female reproductive system AE that results in an enlargement of the patient's ovaries
definition editor: SZ, SS, YH
has_MedDRA_id: 10033157

ovarian mass AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that has an outcome of an abnormal mass appearing in the patient's ovaries
definition editor: SZ, SS, YH
has_MedDRA_id: 10058823

overdose AE
type: Class
subclass of: incorrect dose administration
definition: Incorrect dose administration AE that results in the ingestion or application of a drug in greater quantities than recommended
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007287.htm
has_MedDRA_id: 10033295

oxygen saturation decreased AE
type: Class
subclass of: oxygen saturation abnormal AE
definition: an oxygen saturation abnormal AE that has an outcome of a decreased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen
definition editor: SZ, SS, YH, EB
definition source: WEB: Primary Source: http://www.mayoclinic.com/health/hypoxemia/MY00219\ Secondary Source: http://medical-dictionary.thefreedictionary.com/oxygen+saturation
has_MedDRA_id: 10033318

pain in jaw AE
type: Class
subclass of: pain AE
definition: a pain AE that has an outcome of pain in the set of bones that hold the teeth
definition editor: SZ, SS, YH
has_MedDRA_id: 10033433
see also: HPO: HP_0200023
see also: SIDER: C0236000

pain of skin AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002097
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE located in the skin
definition editor: SZ, SS, YH, MW
has_MedDRA_id: 10033474
see also: HPO: HP_0010833
see also: SIDER: C0241136

palmar erythema AE
type: Class
subclass of: erythema AE
definition: a erythema AE that is characterized by the reddening of the palms at the thenar and hypothenar eminences
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/18039017
has_MedDRA_id: 10033551
see also: HPO: HP_0007548
see also: SIDER: C0014745

palmar-plantar erythrodysesthesia syndrome AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin AE generally caused by chemotherapy that is characterized by the palms and soles becoming red, swollen, numb and the skin peeling.
editor note: YH: MedDRA: 10033553 is for "palmar-plantar erythrodysaesthesia syndrome"; MedDRA: 10054524 is for "palmar-plantar erythrodysesthesia syndrome".
definition editor: SZ, SS, YH, MW
alternative term: Hand Food Syndrome AE
alternative term: palmar-plantar erythrodysaesthesia syndrome AE
definition source: WEB: http://news.cancerconnect.com/hand-foot-syndrome-palmar-plantar-erythrodysesthesia/
see also: CTCAE: E13672
see also: NCIt: C27177
see also: UMLS CUI: C0549410

pancreatic mass AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001264
definition: Tumor AE that results in an undifferentiated growth in the patient's pancreas
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://stanfordhospital.org/digestivehealth/pancreas/conditions/pancreatic-cysts-symptoms-diagnosis.html Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22855657
has_MedDRA_id: 10049082

pancreatitis acute AE
type: Class
subclass of: pancreatitis AE
definition: a pancreatitis AE that has an outcome of sudden inflammation of the pancreas
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000287.htm
has_MedDRA_id: 10033647
see also: HPO: HP_0001735
see also: SIDER: C0001339

pancreatitis relapsing AE
type: Class
subclass of: pancreatitis AE
definition: a pancreatitis AE that results in pancreatitis reoccurring in the patient
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002129/
has_MedDRA_id: 10033657

pancytopenia AE
type: Class
subclass of: hematopoietic system AE
definition: Hematopoietic System AE that results in a reduction in the amount of red and white blood cells and platelets in blood
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pancytopenia
has_MedDRA_id: 10033661
see also: HPO: HP_0001876
see also: SIDER: C0030312

papilloedema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: an edema AE that has an outcome of optic disc swelling that is caused by increased intracranial pressure
definition editor: SZ, SS, YH
alternative term: papilledema AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Papilloedema
has_MedDRA_id: 10033703
has_MedDRA_id: 10033712
see also: CTCAE: E10411
see also: HPO: HP_0001085
see also: NCIt: C3307
see also: SIDER: C0030353

adverse event risk difference
type: Class
subclass of: data item
definition: a data item that represents the incidence of the adverse event among recipients of a medical intervention (e.g., vaccinatoin) minus the incidence of the adverse event among otherwise similar nonrecipients.
editor note: The AE risk difference depends on both the background incidence of the adverse event (i.e., among nonrecipients) and the relative risk of its occurence in medical intervention recipients versus nonrecipients. Even when the AE rlative risk is high, the AE risk difference will be low if the event is extremely rare.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 27.

parathyroid tumor benign AE
type: Class
subclass of: benign tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001132
definition: Tumor AE that results in a benign tumor in the parathyroid region
definition editor: SZ, SS, YH
alternative term: parathyroid tumour benign AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001188.htm
has_MedDRA_id: 10033964

paronychia AE
type: Class
subclass of: skin infection AE
definition: a skin infection AE thar occurs around the fingernails and toenailsnail. Bacteria or a type of yeast called Candida cause this infection. Bacteria and yeast can even combine into one infection.
definition editor: SZ, SS, YH, MW
alternative term: nail infection AE
definition source: WEB: http://www.healthline.com/health/paronychia
definition source: WEB: https://en.wikipedia.org/wiki/Paronychia
has_MedDRA_id: 10034016
see also: HPO: HP_0001818
see also: SIDER: C0030578

pathological fracture AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of a broken bone caused by disease leading to weakenss of the bone, commonly osteoporosis
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pathological+fracture
has_MedDRA_id: 10034156
see also: HPO: HP_0005744
see also: SIDER: C0016663

pericardial effusion AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: myocardial infarction AE
subclass of: Restriction
  on property: is evidence of
  some values from: viral cardiomyopathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiac disorder AE that has an outcome of abnormal accumulation of fluid in the pericardial cavity
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110902/
has_MedDRA_id: 10034474
see also: CTCAE: E10172
see also: HPO: HP_0001698
see also: NCIt: C3319
see also: SIDER: C0031039

perineal pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that results in soreness around the vaginal opening after giving birth
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/20002420
has_MedDRA_id: 10061339

periodontal disease AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a digestive system AE that has an outcome of inflammation and infection that destroys the tissues that support the teeth, including the gums, the periodontal ligaments and the tooth sockets
definition editor: SZ, SS, YH
alternative term: gingivitis AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002051/
Chinese translation: 牙龈炎
has_MedDRA_id: 10034536
see also: CTCAE: E10935
see also: HPO: HP_0000704
see also: NCIt: C63743
see also: SIDER: C0031090

periodontitis AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of inflammation and infection of the ligaments and bones that support the teeth
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002054/
has_MedDRA_id: 10034539
see also: HPO: HP_0000704
see also: SIDER: C0031099

peripheral ischemia AE
type: Class
subclass of: ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an ischaemia AE that has an outcome of restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism
editor note: YH: MedDRA: 10034576 is for "peripheral ischaemia"; MedDRA: 10034578 is for "peripheral ischemia".
definition editor: SZ, SS, YH
alternative term: peripheral ischaemia AE
definition source: WEB: Primary Source: http://www.medterms.com/script/main/art.asp?articlekey=4052 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/6430442
Chinese translation: 外周缺血
has_MedDRA_id: 10034576
has_MedDRA_id: 10034578
see also: HPO: HP_0002597
see also: NCIt: C78535
see also: SIDER: C0235490

peripheral motor neuropathy AE
type: Class
subclass of: motor neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a motor neuropathy AE that results in damage to the nerves outside of the brain and spinal cord
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001619/
has_MedDRA_id: 10034580
see also: HPO: HP_0007178
see also: SIDER: C0235025

peripheral sensorimotor neuropathy AE
type: Class
subclass of: peripheral sensory neuropathy AE
definition: a peripheral sensory neuropathy AE that results in the patient losing the ability to move or feel.
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000750.htm
has_MedDRA_id: 10056673
comment: Neuropathy can affect nerves that provide feeling (sensory neuropathy) or cause movement (motor neuropathy). It can also affect both, in which case it is called a sensorimotor neuropathy.

peripheral sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000010
definition: a sensory neuropathy AE that has an outcome of damaged nerves outside the brain and spinal cord
definition editor: SZ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Peripheral+sensory+neuropathy
has_MedDRA_id: 10034620
see also: HPO: HP_0000763
see also: SIDER: C0151313

peritonsillar abscess AE
type: Class
subclass of: abscess AE
definition: an abscess AE that results in a collection of infected material around the tonsils
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001981/
has_MedDRA_id: 10034686
see also: HPO: HP_0001739
see also: SIDER: C0031157

pertussis AE
type: Class
subclass of: respiratory system AE
definition: Respiratory system AE characterized by the whooping cough
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002528/
has_MedDRA_id: 10034738

petechiae AE
type: Class
subclass of: hemorrhage AE
definition: a hemorrhage AE that has an outcome of tiny pinpoint red dots that form due to broken blood vessels under the skin
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm
has_MedDRA_id: 10034754
see also: HPO: HP_0000967
see also: MP: MP_0008816
see also: SIDER: C0031256

pharyngeal inflammation AE
type: Class
subclass of: inflammation AE
definition: Inflammation AE that results in an inflammation of the pharyngeal region
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/11172144
has_MedDRA_id: 10065716

phlebitis superficial AE
type: Class
subclass of: phlebitis AE
definition: a phlebitis that is characterized by blood clots that occur in different locations
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Thrombophlebitis Secondary Source: http://emedicine.medscape.com/article/463256-overview
has_MedDRA_id: 10034902

photodermatosis AE
type: Class
subclass of: skin AE
definition: a skin AE that results in the patient's skin becoming diseased due to exposure to sunlight
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/photodermatosis Secondary Source http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063367/
has_MedDRA_id: 10051246
see also: HPO: HP_0000992
see also: SIDER: C0920193

photosensitivity reaction AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a skin AE that shows a cutaneous disease as a result of sun allergy and may be induced by different triggers such as a chemical.
editor note: MedDRA: 10034972 and UMLS CUI: C0162830 are for "photosensitivity reaction"; MedDRA: 10034966 and UMLS CUI: C0349506 are for "photosensitivity".
definition editor: SZ, SS, YH, MW
alternative term: photosensitivity AE
definition source: WEB: http://emedicine.medscape.com/article/1049648-overview
definition source: WEB: http://www.merckmanuals.com/home/skin-disorders/sunlight-and-skin-damage/photosensitivity-reactions
has_MedDRA_id: 10034966
has_MedDRA_id: 10034972
see also: CTCAE: E13680
see also: HPO: HP_0000992
see also: NCIt: C38004
see also: SIDER: C0162830
see also: UMLS CUI: C0349506; UMLS CUI: C0162830

pigmentation disorder AE
type: Class
subclass of: skin discoloration AE
definition: a skin AE that has an outcome of loss or reduction in human skin color, may be related to loss of melanocytes or inability of melanocytes to produce melanin
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/skinpigmentationdisorders.html
has_MedDRA_id: 10062080
see also: HPO: HP_0001000
see also: SIDER: C0549567

atrioventricular block AE
type: Class
subclass of: conduction system disorder AE
definition: a conduction system disorder AE that refers to partial or complete block of electrical impulses originating in the atrium or sinus node, preventing them from reaching the AV node and ventricles
definition editor: SS
alternative term: AV block
alternative term: heart block
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751
has_MedDRA_id: 10003671
see also: HPO: HP_0001678
see also: SIDER: C0004245

pleural effusion AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has an outcome of fluid buildup between the layers of tissue that line the lungs and chest cavity
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001150/
has_MedDRA_id: 10035598
see also: HPO: HP_0002202
see also: SIDER: C0032227

pleural hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has an outcome of bleeding in the pleural cavity, the potential space between the two pleura of the lungs
editor note: MedDRA: 10035601 is for "pleural haemorrhage"; MedDRA: 10055319 is for "pleural hemorrhage".
definition editor: SZ, SS, YH
alternative term: pleural haemorrhage AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemothorax
has_MedDRA_id: 10035601
has_MedDRA_id: 10055319
see also: CTCAE: E13492
see also: NCIt: C50582
see also: UMLS CUI: C0019123

pleurisy AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of inflammation of the lining of the lungs and chest that leads to chest pain
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002347/
has_MedDRA_id: 10035618
see also: HPO: HP_0002102
see also: SIDER: C0032231

pleuritic pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE induced by inflammation in the lungs that is characterized by sharp or stabbing pain in the chest
definition editor: SZ, SS, YH, MW
definition source: WEB: http://pleuriticchestpain.net/, http://medical-dictionary.thefreedictionary.com/Pleuritic+chest+pain
has_MedDRA_id: 10035623

pneumatosis intestinalis AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disorder AE that results in gas cysts developing within the walls of the small or large intestine
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/9530294
has_MedDRA_id: 10057030

pneumocystis jiroveci pneumonia AE
type: Class
subclass of: pneumonia AE
definition: a pneumonia AE that has an outcome of a fungal infection of the lungs by Pneumocystis jiroveci
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001692/
has_MedDRA_id: 10064108
see also: HPO: HP_0002096
see also: SIDER: C1535939

pneumomediastinum AE
type: Class
subclass of: respiratory system AE
definition: Respiratory System AE that results in air being present in the mediastinum
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001148/
has_MedDRA_id: 10050184

pneumonia aspiration AE
type: Class
subclass of: pneumonia AE
definition: a pneumonia AE that has an outcome of inflammation in the lungs and airways to the lungs from breathing in foreign material
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000121.htm
has_MedDRA_id: 10035669
see also: HPO: HP_0002100
see also: SIDER: C0032290

pneumonia primary atypical AE
type: Class
subclass of: pneumonia AE
definition: a pneumonia AE that has an outcome of an acute systemic disease with involvement of the lungs, caused by Mycoplasma pneumoniAE and marked by high fever and cough
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/primary+atypical+pneumonia
has_MedDRA_id: 10035730

pneumonitis AE
type: Class
subclass of: lung inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung inflammation AE located in the lung tissue
definition editor: SZ, SS, YH, MW
alternative term: pulmonitis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pneumonitis
has_MedDRA_id: 10035742

pneumothorax AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung disorder AE that has an outcome of a collapsed lung due to collection of air in the space around the lungs.
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001151/
has_MedDRA_id: 10035759
see also: HPO: HP_0006522
see also: SIDER: C0032326

pollakiuria AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE that results in abnormally frequent urination
definition editor: SZ, SS, YH
alternative term: frequent micturition AE
alternative term: polyuria AE
definition source: WEB: http://www.merriam-webster.com/medical/pollakiuria
has_MedDRA_id: 10036018
see also: HPO: HP_0000103
see also: SIDER: C0042023

polycythemia vera AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic disorder AE that results in the bone marrow producing too many red blood cells
definition editor: SZ, SS, YH
alternative term: polycythaemia vera AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Polycythaemia+vera
has_MedDRA_id: 10036057

portal hypertension AE
type: Class
subclass of: hypertension AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002107
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hypertension AE located in the heptatic portal system caused by obstruction or occlusion that produces splenomegaly and ascites in its later stages
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21129318
definition source: http://www.merriam-webster.com/medlineplus/portal%20hypertension
has_MedDRA_id: 10036200
see also: CTCAE: E11238
see also: HPO: HP_0001409
see also: NCIt: C3119
see also: SIDER: C0020541

portal vein thrombosis AE
type: Class
subclass of: thrombosis AE
subclass of: venous thrombosis AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002017
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a thrombosis AE that has an outcome of formation of a blood clot affecting the hepatic portal vein, can lead to hypertension or reduction of blood supply to the liver
definition editor: SZ, SS, YH
alternative term: PVT
definition source: WEB: http://medical-dictionary.thefreedictionary.com/portal+vein+thrombosis
has_MedDRA_id: 10036206
see also: CTCAE: E11243
see also: NCIt: C78565

post lumbar puncture syndrome AE
type: Class
subclass of: syndrome AE
definition: a syndrome that results in the patient suffering a set of problems after having a spinal tap procedure
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19921503
has_MedDRA_id: 10060854

postoperative fever AE
type: Class
subclass of: fever AE
definition: Fever AE that results in a fever occurring after an operation
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22774619
has_MedDRA_id: 10050087

postoperative thrombosis AE
type: Class
subclass of: thrombosis AE
definition: A thrombosis AE that occurs after an operation that results in a blood clot in a blood vessel disrupting blood flow throughout the body
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19756494
has_MedDRA_id: 10050902

pregnancy on contraceptive AE
type: Class
subclass of: female reproductive system AE
definition: Female reproductive system AE that results in the patient getting pregnant even when using a contraceptive
definition editor: SZ, SS, YH
has_MedDRA_id: 10067667

premature baby AE
type: Class
subclass of: perinatal AE
definition: a perinatal AE that has an outcome of premature baby
definition editor: SZ, SS, YH
has_MedDRA_id: 10036590

premature labor AE
type: Class
subclass of: pregnancy AE
definition: a pregnancy AE that has an outcome of labor beginning prior to the 37th week of gestation
definition editor: SZ, SS, YH
alternative term: premature labour AE
alternative term: preterm labor AE
definition source: WEB: http://wordnetweb.princeton.edu/perl/webwn?s=premature%20labor
has_MedDRA_id: 10036600

presyncope AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a sensory capability AE that has an outcome of a near-fainting episode which may include lightheadedness, dizziness, severe weakness, blurred vision, which may precede syncopal episode
definition editor: SZ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/presyncope
has_MedDRA_id: 10036653
see also: HPO: HP_0002321
see also: SIDER: C0700200

primary sequestrum AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of a piece of dead bone that completely separates from sound bone during the process of necrosis
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/primary+sequestrum
has_MedDRA_id: 10052460

prinzmetal angina AE
type: Class
subclass of: coronary artery disorder AE
definition: a coronary artery disorder AE that results in cardiac pain at rest that occurs in cycles
definition editor: SZ, SS, YH
alternative term: Prinzmetal's angina AE
alternative term: coronary vessel spasm AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/prinzmetal+angina
has_MedDRA_id: 10036759
see also: HPO: HP_0001681
see also: SIDER: C0002963

proctalgia AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that results in the pain located at the anus or in the rectum
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/proctalgia
has_MedDRA_id: 10036772
see also: HPO: HP_0004378
see also: SIDER: C0034886

endodontic procedure
type: Class
subclass of: dental caries AE
definition: A medical intervention that is a procedure occuring in the inside structures of the tooth, including the dental pulp and tooth root, and the periapical tissue surrounding the root.
definition editor: YH, SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/endodontic
has_MedDRA_id: 10051085

endotracheal intubation
type: Class
subclass of: medical intervention
definition: A medical intervention that creates a passage of a tube through the nose or mouth into the trachea for maintenance of the airway, as during the administration of anesthesia.
definition editor: YH, SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Endotracheal+intubation
has_MedDRA_id: 10067450

gastrectomy
type: Class
subclass of: surgery
definition: A surgery that has an outcome of the removal of part or all of the stomach.
definition editor: YH, SS
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002945.htm
has_MedDRA_id: 10061965

productive cough AE
type: Class
subclass of: cough AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cough AE that has an outcome of secretions that could be mucous or blood
definition editor: SZ, SS, YH, MW
definition source: WEB: http://coldflu.about.com/od/glossary/g/productivecough.htm
has_MedDRA_id: 10036790

prostate cancer AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002367
definition: a tumor AE that has an outcome of cancer that starts in the prostate gland, the small structure that wraps around the urethra carrying urine out of the body
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/
has_MedDRA_id: 10060862
see also: HPO: HP_0012125
see also: SIDER: C0376358

prostate examination abnormal AE
type: Class
subclass of: physical examination result abnormal AE
definition: a physical examination result abnormal AE that results in a prostate exam being different than expected
definition editor: SZ, SS, EB
has_MedDRA_id: 10055025

prostatic specific antigen increased AE
type: Class
subclass of: male reproductive system AE
definition: a male reproductive system AE that has an outcome of an increased amount of prostatic specific antigen, a glycoprotein enzyme present in small quantities in the serum of men with healthy prostates. May indicate prostate cancer or prostate disorders
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23277770
has_MedDRA_id: 10036975

protein total abnormal AE
type: Class
subclass of: protein and chemistry analysis result abnormal AE
definition: a protein and chemistry analysis result abnormal AE that is characterized by the protein level in the body being abnormal
definition editor: SZ, SS, YH, EB
has_MedDRA_id: 10037012

prothrombin level decreased AE
type: Class
subclass of: prothrombin level abnormal AE
definition: a prothrombin level abnormal AE that is characterized by a decrease in level of prothrombin in body
definition editor: SZ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/prothrombin
has_MedDRA_id: 10037050

prothrombin time prolonged AE
type: Class
subclass of: prothrombin time abnormal AE
definition: a prothrombin time abnormal AE that has an outcome of prolonged time for plasma in the blood to clot
definition editor: SZ, SS, YH, EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003652.htm
has_MedDRA_id: 10037063

pseudomembranous colitis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of infection in the large intestine with an overgrowth of Clostridium difficile bacteria
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001305/
has_MedDRA_id: 10037128
see also: HPO: HP_0002583
see also: SIDER: C1257843

pseudomonas infection AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE that has an outcome of infection by genus Pseudomonas, typically targets respiratory tract
definition editor: SZ, SS, YH
definition source: WEB: http://emedicine.medscape.com/article/970904-overview
has_MedDRA_id: 10061471
see also: HPO: HP_0005429
see also: SIDER: C0033817

psychosomatic disease AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that results in physical pain being caused by the patient's life stresses
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/psychosomatic+disease
has_MedDRA_id: 10049587

psychotic disorder AE
type: Class
subclass of: psychiatric disorder AE
definition: A mental disorder AE that results in abnormal condition of the mind
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/psychotic+disorder
has_MedDRA_id: 10061920
see also: HPO: HP_0000709
see also: SIDER: C0033975

evidence of biological plausity of adverse event causality
type: Class
subclass of: adverse event causality evidence
definition: an adverse event causality evidence that has an outcome of biological plausity.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.

pulmonary arterial hypertension AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of hypertension or abnormally high blood pressure in the arteries of the lungs
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/
has_MedDRA_id: 10064911
see also: HPO: HP_0002092
see also: SIDER: C2973725

pulmonary congestion AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of engorgement of pulmonary vessels with transudation of fluid into the alveolar and interstitial spaces, seen in cardiac disease, infections, and certain injuries
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pulmonary+congestion
has_MedDRA_id: 10037368
see also: HPO: HP_0004930
see also: SIDER: C0242073

pulmonary embolism AE
type: Class
subclass of: arterial embolism AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002048
definition: an arterial embolism AE that results in the blockage of the main artery of a lung or one of its branches by a substance that has travelled from elsewhere in the body through the bloodstream
editor note: [SS] moved by relation 'SubclassOf' from lung disorder AE to arterial embolism on 01/07/14
definition editor: SZ, SS, YH
alternative term: pulmonary artery thrombosis AE
alternative term: pulmonary thrombosis AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299609
has_MedDRA_id: 10037377
has_MedDRA_id: 10037437
see also: HPO: HP_0002204
see also: SIDER: C0034065

pulmonary fibrosis AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung disorder AE wih the outcome of damaged or scarred lung tissue. Thickened tissue impairs lung function
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.mayoclinic.com/health/pulmonary-fibrosis/DS00927
has_MedDRA_id: 10037383
see also: HPO: HP_0002206
see also: SIDER: C0034069

pulmonary hemorrhage AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of acute bleeding from the lung, especially in the upper respiratory tract and the endotracheal tube
definition editor: SZ, SS, YH
alternative term: pulmonary haemorrhage AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23217914
has_MedDRA_id: 10037394

pulmonary hypertension AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung disorder AE that has an outcome of abnormally high blood pressure in the arteris of the lungs
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/
has_MedDRA_id: 10037400
see also: HPO: HP_0002092
see also: SIDER: C0020542

pulmonary mass AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that has an outcome of an abnormal spot in the lungs that is more than 3 cm in size
definition editor: SZ, SS, YH
definition source: WEB: http://lungcancer.about.com/od/whatislungcancer/a/Lung-Mass.htm
has_MedDRA_id: 10056342

pulmonary edema AE
type: Class
subclass of: lung AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung disorder AE that has an outcome of edema or abnormal buildup of fluid in the air sacs of the lungs, leads to shortness of breath
editor note: MedDRA: 10037423 is for "pulmonary oedema"; MedDRA: 10037375 is for "pulmonary edema"
definition editor: SZ, SS, YH, MW
alternative term: pulmonary oedema AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001195/
see also: CTCAE: E13521
see also: HPO: HP_0100598
see also: NCIt: C26868
see also: SIDER: C0034063
see also: UMLS CUI: C0034063

pulse absent AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that has an outcome of an inability to detect pulse
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003078.htm
has_MedDRA_id: 10037469

pulse pressure decreased AE
type: Class
subclass of: pulse absent AE
definition: a cardiovascular disorder AE that has an outcome of abnormally low pulse pressure, less than 25% of systolic value. Can indicate blood loss or low stroke volume
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pulse+pressure
has_MedDRA_id: 10037480

purulent discharge AE
type: Class
subclass of: adverse event
definition: an adverse event with an outcome of the release or secretion of pus
definition editor: SZ, SS, YH
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=21858
has_MedDRA_id: 10037569

pyelocaliectasis AE
type: Class
subclass of: kidney AE
definition: a kidney disorder AE that is characterized by the dilation of calices, usually due to obstruction or infection
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/calicectasis
has_MedDRA_id: 10061927

radiation injury AE
type: Class
subclass of: injury AE
definition: an injury AE caused by ionizing radiation
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Radiation+Injuries
has_MedDRA_id: 10037760

radiation mucositis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that results in the inflammation of mucous membranes lining the digestive tract. Caused by radiation, can lead to mouth sores
definition editor: SZ, SS, YH
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=19881
has_MedDRA_id: 10037763

radiation esophagitis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of inflammation that radiation causes swelling of the esophagus
definition editor: SZ, SS, YH
alternative term: radiation oesophagitis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/esophagitis
has_MedDRA_id: 10048899

radiation pneumonitis AE
type: Class
subclass of: lung inflammation AE
definition: a lung inflammation AE due to radiation therapy
definition editor: SZ, SS, YH
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=8091
has_MedDRA_id: 10037765

radiation skin injury AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation
definition editor: SZ, SS, YH
definition source: WEB: http://www.bt.cdc.gov/radiation/criphysicianfactsheet.asp
has_MedDRA_id: 10063562
see also: NCIt: C3349

rales AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of clicking, rattling or crackling noises made by one or both lungs during inhalation
definition editor: SZ, SS, YH
alternative term: Crackles
definition source: WEB: http://medical-dictionary.thefreedictionary.com/crackles
has_MedDRA_id: 10037833

erythematous rash AE
type: Class
subclass of: rash AE
definition: a rash ae adverse event that results in redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin
definition editor: SZ, SS, YH
alternative term: rash erythematous AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23145421
has_MedDRA_id: 10037855
see also: HPO: HP_0007432
see also: SIDER: C0234913

generalized rash AE
type: Class
subclass of: rash AE
definition: a rash AE occuring in several areas of the body
definition editor: SZ, SS, YH
alternative term: rash (generalized) AE
alternative term: rash generalised AE
definition source: WEB: http://www.freemd.com/rash-generalized/overview.htm
has_MedDRA_id: 10037858
see also: HPO: HP_0000988
see also: SIDER: C0497365

rash pruritic AE
type: Class
subclass of: rash AE
definition: a rash AE that has an outcome of an unpleasant sensation of the skin that provokes the uge to scratch
definition editor: SZ, SS, YH
definition source: WEB: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/pruritus-itch/
has_MedDRA_id: 10037884

recall phenomenon AE
type: Class
subclass of: inflammation AE
definition: an inflammation AE that has an outcome of an inflammatory reaction limited to a previously X-irradiated field when the patient is treated months/years later with certain drugs
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/7577597
has_MedDRA_id: 10060856

rectal hemorrhage AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Digestive System AE that results in bleeding in the rectal area
definition editor: SZ, SS, YH
alternative term: rectal haemorrhage AE
has_MedDRA_id: 10038063
has_MedDRA_id: 10038064
see also: CTCAE: E10955
see also: HPO: HP_0002573
see also: NCIt: C27054
see also: SIDER: C0267596

red blood cell count decreased AE
type: Class
subclass of: red blood cell count abnormal AE
definition: a red blood cell count abnormal AE that has an outcome of a decrease in red blood cells
definition editor: SZ, SS, YH, EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003644.htm
has_MedDRA_id: 10038153
see also: HPO: HP_0001903
see also: SIDER: C0427457

reflux gastritis AE
type: Class
subclass of: digestive system AE
definition: a digestive system disorder AE that results in the inflammation of the stomach lining due to reflux
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/gastritis
has_MedDRA_id: 10057969

reflux esophagitis AE
type: Class
subclass of: digestive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001043
definition: a digestive system AE located in the esophagus, can present with heartburn, and nausea, caused by gastroesophageal reflux disease
definition editor: SZ, SS, YH
alternative term: reflux oesophagitis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/esophagitis
has_MedDRA_id: 10038263
see also: HPO: HP_0100633
see also: SIDER: C0014869

renal failure AE
type: Class
subclass of: kidney AE
definition: a kidney disorder AE that results in kidneys failing to adequately filter toxins and waste from the blood
definition editor: SZ, SS, YH
alternative term: kidney failure AE
alternative term: renal insufficiency AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/renal+failure
has_MedDRA_id: 10038435
see also: HPO: HP_0000083
see also: SIDER: C0035078

acute kidney injury AE
type: Class
subclass of: kidney AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a kidney disorder AE that results in the rapid loss or decline of kidney function
editor note: As shown on the renal.org website (http://www.renal.org/guidelines/modules/acute-kidney-injury), Acute kidney injury (AKI) has now replaced the term acute renal failure.
definition editor: SZ, SS, YH, Izabela Birsanescu, MW
alternative term: AKI
alternative term: renal failure acute AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/acute+renal+failure
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/kidney-failure/basics/definition/con-20024029
has_MedDRA_id: 10038436
has_MedDRA_id: 10069339
comment: Acute kidney failure occurs when kidneys become unable to filter waste products from blood.
see also: HPO: HP_0001919
see also: SIDER: C0022660

renal impairment AE
type: Class
subclass of: kidney AE
definition: a kidney disorder AE that results in the kidneys failing to adequately filter toxins and waste from the blood
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23263712
has_MedDRA_id: 10062237
see also: HPO: HP_0000082
see also: SIDER: C0341697

renal tubular atrophy AE
type: Class
subclass of: OAE_0004452
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0009773
definition: kidney disorder AE that results in the renal tubule wasting away and losing strength/functional abilities
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/nephron
has_MedDRA_id: 10038536

renal vessel disorder AE
type: Class
subclass of: kidney AE
definition: a kidney disorder AE that results in the renal artery narrowing
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/renal+artery+stenosis
has_MedDRA_id: 10038553

respiratory disorder AE
type: Class
subclass of: respiratory system AE
definition: Respiratory system AE that is characterized by conditions that affect organs and systems that deal with gas exchange
definition editor: SZ, SS, YH
definition source: WEB: http://www.thefreedictionary.com/respiratory+disorder
has_MedDRA_id: 10038683
see also: HPO: HP_0002086
see also: SIDER: C0035204

respiratory acidosis AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has an outcome of a condition where lungs cannot remove all the carbon dioxide the body produces, makes body fluid too acidic
definition editor: SZ, SS, YH
alternative term: respiratory failure AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001154/
has_MedDRA_id: 10038695
see also: HPO: HP_0004877
see also: SIDER: C1145670

respiratory rate increased AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of a ventilory rate greater than 20 breaths per minute
definition editor: SZ, SS, YH
definition source: WEB: http://www.thefreedictionary.com/tachypnea
has_MedDRA_id: 10038712

respiratory tract hemorrhage AE
type: Class
subclass of: respiratory system AE
definition: Respiratory System AE that results in bleeding somewhere in the respiratory system
definition editor: SZ, SS, YH
alternative term: respiratory tract haemorrhage AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/8692086
has_MedDRA_id: 10038727

respiratory tract infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000065
definition: an infection AE that has an outcome of infection in the respiratory tract, includes pneumonia as well as lung abscess and acute bronchitis
definition editor: SZ, SS, YH
definition source: WEB: http://www.thefreedictionary.com/respiratory+tract+infection
has_MedDRA_id: 10062352
see also: HPO: HP_0002873
see also: SIDER: C0035243

retinal hemorrhage AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000966
definition: an eye disorder AE that has an outcome of bleeding in the eye
definition editor: SZ, SS, YH
alternative term: retinal haemorrhage AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/retinal+hemorrhage
has_MedDRA_id: 10038867
see also: HPO: HP_0000573
see also: SIDER: C0035317

retinal pigment epithelial tear AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000966
definition: Eye Disorder AE that results in a tearing of retinal pigment epithelial tissue
definition editor: SZ, SS, YH
has_MedDRA_id: 10062971

retrograde amnesia AE
type: Class
subclass of: amnesia AE
definition: Amnesia AE that results in the patient forgeting things that happened before the onset of an injury or disease
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/retrograde+amnesia
has_MedDRA_id: 10038965
see also: HPO: HP_0002354
see also: SIDER: C0002624

reversible posterior leukoencephalopathy syndrome AE
type: Class
subclass of: encephalopathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an encephalopathy AE that is characterized by headache, confusion, seizures and visual loss, tends to resolve over time
definition editor: SZ, SS, YH, MW
has_MedDRA_id: 10063761

rhabdomyolysis AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event that results in damaged skeletal muscle tissue breaks down rapidly
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/rhabdomyolysis
has_MedDRA_id: 10039020
see also: HPO: HP_0009045
see also: SIDER: C0035410

right ventricular failure AE
type: Class
subclass of: right ventricular dysfunction AE
definition: a right ventricular dysfunction AE that has an outcome of congestive heart failure manifested by distention of the neck veins, enlargement of the liver, and dependent edema
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/right+ventricular+failure
has_MedDRA_id: 10039163
see also: HPO: HP_0001708
see also: SIDER: C2939447

ruptured ectopic pregnancy AE
type: Class
subclass of: pregnancy AE
definition: A pregnancy AE that results in the growing pregnancy in a woman's fallopian tube becoming larger than the tube and causing it to rupture
definition editor: SZ, SS, YH
definition source: WEB: http://www.freemd.com/ruptured-ectopic-pregnancy/overview.htm
has_MedDRA_id: 10048407

salivary gland disorder AE
type: Class
subclass of: abnormal salivary gland physiology AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001044
definition: an abnormal salivary gland physiology AE that results in the salivary glands becoming irritated and/or swollen
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/salivaryglanddisorders.html
has_MedDRA_id: 10061935
see also: HPO: HP_0010286
see also: SIDER: C0036093

scab AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a hard coating formed during the wound healing reconstruction phase
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/scab
has_MedDRA_id: 10039509
see also: HPO: HP_0007564
see also: SIDER: C0205204

sciatic nerve injury AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001322
definition: a nervous system AE that results in the sciatic nerve losing its sensory capabilities
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21995439
has_MedDRA_id: 10039670

scleral hyperemia AE
type: Class
subclass of: eye AE
definition: an eye disorder AE that is characterized by an excessive accumulation of blood in the eye
definition editor: SZ, SS, YH
alternative term: scleral hyperaemia AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hyperaemia
has_MedDRA_id: 10052130

senile dementia AE
type: Class
subclass of: behavioral and neurological AE
definition: a dementia AE that results in an elderly patient suffering from dementia
definition editor: SZ, SS, YH
has_MedDRA_id: 10039966

sensation of blood flow AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that results in the patient feeling their blood flow
definition editor: SZ, SS, YH
has_MedDRA_id: 10039996

septic shock AE
type: Class
subclass of: circulatory shock AE
definition: a shock AE that has an outcome of life-threatening low blood pressure
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001689/
has_MedDRA_id: 10040070
see also: HPO: HP_0002718
see also: SIDER: C0036983

sequestrectomy
type: Class
subclass of: surgery
definition: a surgery that leads to the excision of a sequestrum, or a piece of dead bone that has become separated during the process of necrosis
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/sequestrectomy
has_MedDRA_id: 10053437

shift to the left AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: Blood cell lab test abnormal AE showing an increase in the number of immature leukocytes in peripheral blood. (in hematology) a predominance of immature leukocytes noted in a differential white blood cell count. It is usually indicative of an infection or inflammation. The term derives from a graph of blood components in which immature cell frequencies appear on the left side of the graph.
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/shift
has_MedDRA_id: 10056383

shock hemorrhagic AE
type: Class
subclass of: circulatory shock AE
definition: a physiological shock AE that has an outcome of hypovolemic shock resulting from acute hemorrhage and characterized by hypotension, tachycardia, oliguria, and by pale, cold and clammy skin
definition editor: SZ, SS, YH
alternative term: shock haemorrhagic AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+shock
has_MedDRA_id: 10049771

sigmoiditis AE
type: Class
subclass of: gastrointestinal disorder AE
definition: a gastrointestinal disorder AE that results in the sigmoid colon being inflamed
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/sigmoiditis
has_MedDRA_id: 10052058

sinus disorder AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has an outcome of disease in the air-filled spaces that surround the nasal cavity, above the eyes and behind the ethmoids
definition editor: SZ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/paranasal+sinuses
has_MedDRA_id: 10062244

sinus tachycardia AE
type: Class
subclass of: tachycardia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002351
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a tachycardia AE that has an outcome of elevated impulses originating from the sinoatrial node, greater than 100 bpm
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/sinus+tachycardia
has_MedDRA_id: 10040752
see also: CTCAE: E10214
see also: HPO: HP_0001649
see also: NCIt: C26889
see also: SIDER: C0039239

skin chapped AE
type: Class
subclass of: skin AE
definition: a skin AE that is characterized by sore, cracked, or rough skin, usually on the hands, face and lips.
definition editor: SZ, SS, YH
definition source: WEB: http://wellbeing.doctissimo.com/wellbeing-a-z/chapped-skin.html
has_MedDRA_id: 10040813

skin fissures AE
type: Class
subclass of: skin AE
definition: a skin AE that results in linear-like cleavages in the skin
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/fissure
has_MedDRA_id: 10040849

skin hemorrhage AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of bleeding at the skin
definition editor: SZ, SS, YH
alternative term: skin haemorrhage AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm
has_MedDRA_id: 10064265
see also: HPO: HP_0000967
see also: SIDER: C0852361

skin hyperpigmentation AE
type: Class
subclass of: skin discoloration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a skin AE that has an outcome of darkening in an area of skin or nails caused by increased melanin
definition editor: SZ, SS, YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hyperpigmentation
has_MedDRA_id: 10040865
see also: HPO: HP_0010284
see also: SIDER: C0162834

skin infection AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a skin AE that has an outcome of infection. Can be bacterial, fungal, parasitic or viral
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/skin+infection
has_MedDRA_id: 10040872
see also: CTCAE: E11568
see also: HPO: HP_0001581
see also: NCIt: C35025
see also: SIDER: C0037278

skin laceration AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a jagged wound, can be shallow cuts or deep gahes that penetrate through muscle to internal organs and bone
definition editor: SZ, SS, YH
definition source: WEB: http://www.mdguidelines.com/lacerations
has_MedDRA_id: 10058818

skin lesion AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a superficial growth or patch of the skin that does not resemble the area surrounding it
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Skin+Lesions
has_MedDRA_id: 10040882
see also: HPO: HP_0011355
see also: SIDER: C0037284

skin reaction AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of exposure of skin to nonspecific irritants or from the action of specific allergens
definition editor: SZ, SS, YH
definition source: WEB: http://encyclopedia2.thefreedictionary.com/Skin+Reactions
has_MedDRA_id: 10040914

skin toxicity AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of irritation, sensitization and phototoxicity
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dermal+toxicity
has_MedDRA_id: 10059516

sleep disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in irregular sleep patterns
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/sleep+disorder
has_MedDRA_id: 10040984
see also: HPO: HP_0002360
see also: SIDER: C0851578

sleep-related eating disorder AE
type: Class
subclass of: eating disorder AE
definition: an eating disorder AE that is characterized by patient searching for food while asleep
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23205019
has_MedDRA_id: 10067315

small intestinal obstruction AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002108
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the small intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors
definition editor: SZ, SS, YH
definition source: WEB: http://www.mayoclinic.com/health/intestinal-obstruction/DS00823
has_MedDRA_id: 10041101
see also: CTCAE: E11021
see also: HPO: HP_0005214
see also: NCIt: C78615
see also: SIDER: C0235329

small intestinal resection
type: Class
subclass of: surgery
definition: a surgery that is characterized by all of or part of the small intestine needing to be removed
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002943.htm
has_MedDRA_id: 10041105

small intestinal stenosis AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002108
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a gastrointestinal disorder AE in which the blood vessels in the small intestine narrow
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/stenosis
has_MedDRA_id: 10062263
see also: CTCAE: E11032
see also: NCIt: C78617

small intestine carcinoma AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002108
definition: a tumor AE that results in cancer in the small intestine
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/small+intestine+cancer
has_MedDRA_id: 10054184

small intestine ulcer AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002108
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a gastrointestinal disorder AE that results in an ulcer in the patient's small intestine
definition editor: SZ, SS, YH
has_MedDRA_id: 10041133
see also: CTCAE: E11038
see also: NCIt: C78619

soft tissue infection AE
type: Class
subclass of: connective tissue disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a connective tissue disorder AE that occurs in the non-skeletal tissue, usually subcutaneous and muscle tissue
definition editor: SZ, SS, YH
definition source: WEB: http://www.reference.md/files/D018/mD018461.html
has_MedDRA_id: 10062255
has_exact_synonym: soft tissue infection
see also: CTCAE: E11579
see also: HPO: HP_0002719
see also: NCIt: C79745
see also: SIDER: C0149778

soft tissue injury AE
type: Class
subclass of: connective tissue disorder AE
definition: a connective tissue disorder AE that results in damage to muscles, ligaments, and tendons throughout the body
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22964676
has_MedDRA_id: 10041291

soft tissue necrosis AE
type: Class
subclass of: necrosis AE
definition: a necrosis AE that results in necrosis occurring in soft tissue
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/necrosis
has_MedDRA_id: 10065769

somatoform disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in the patient hvings a mental disorder with symptoms that may suggest physical illness or injury
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/somatoform+disorder
has_MedDRA_id: 10054153

spinal compression fracture AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of vertebra collapse caused by small hairline fractures
definition editor: SZ, SS, YH
definition source: WEB: http://www.webmd.com/osteoporosis/guide/spinal-compression-fractures-causes
has_MedDRA_id: 10041541

spinal cord compression AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002240
definition: a nervious system AE that has an outcome of spinal cord compressed by bone fragments from a vertebral fracture, a tumor, abscess, ruptured intervertebral disc or other lesion
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/spinal+cord+compression
has_MedDRA_id: 10041549
see also: HPO: HP_0002176
see also: SIDER: C0037926

spinal cord neoplasm AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002240
definition: Tumor AE that results in a tumor in the patient's spinal cord
definition editor: SZ, SS, YH
has_MedDRA_id: 10062261

spinal osteoarthritis AE
type: Class
subclass of: osteoarthritis AE
definition: Spinal osteoarthritis AE is a osteoarthritis AE that has an outcome of degeneration of the protective cartilage that cushions the tops of bones, causes swelling and pain and may cause development of osteophytes.
definition editor: SZ, SS, YH
definition source: WEB: http://www.webmd.com/osteoarthritis/guide/spinal-osteoarthritis-degenerative-arthritis-of-the-spine
has_MedDRA_id: 10041591
see also: HPO: HP_0002758
see also: SIDER: C0949690

splenomegaly AE
type: Class
subclass of: hematopoietic system AE
definition: an immune system disorder AE that has an outcome of a larger-than-normal spleen, affects blood filtration
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003276.htm
has_MedDRA_id: 10041660
see also: HPO: HP_0001744
see also: SIDER: C0038002

sputum culture positive AE
type: Class
subclass of: microbiology and serology investigation result abnormal AE
definition: a microbiology and serology investigation result abnormal AE that has an outcome of bacterial infection in the lungs or breathing passages
definition editor: SZ, SS, YH, EB
definition source: WEB: http://www.webmd.com/lung/sputum-culture
has_MedDRA_id: 10051612

sputum increased AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that shows increased sputum, which results in mucous material coughed up from the lungs by the patient.
definition editor: SZ, SS, YH
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=5539
has_MedDRA_id: 10041812
see also: HPO: HP_0002105
see also: SIDER: C0235567

squamous cell carcinoma AE
type: Class
subclass of: skin AE
definition: a skin AE that has an outcome of a type of nonmelanoma skin cancer
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001832/
has_MedDRA_id: 10041823
see also: HPO: HP_0006739
see also: SIDER: C0007137

staphylococcal infection AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE that has an outcome of invasion by Staphylococcus, can present with pus, fever, chills and low blood pressure
definition editor: SZ, SS, YH
definition source: WEB: http://www.medicinenet.com/staph_infection/page2.htm
has_MedDRA_id: 10058080
see also: HPO: HP_0007499
see also: SIDER: C0038160

stasis dermatitis AE
type: Class
subclass of: skin AE
definition: a skin AE that results in the skin in the leg undergoing discoloration due to blood pooling as a result of insufficient venous return
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000834.htm
has_MedDRA_id: 10041955

stent occlusion AE
type: Class
subclass of: device occlusion AE
definition: a device occlusion AE that has an outcome of blockage of the stent, or a tube inserted into body to prevent or counteract a disease-induced, localized flow constriction
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002303.htm
has_MedDRA_id: 10049936

stevens-johnson syndrome AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a skin adverse event that is characterized by cell death causing the epidermis to separate from the dermis
definition editor: SZ, SS, YH, MW
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001854/
has_MedDRA_id: 10042033
see also: HPO: HP_0000951
see also: SIDER: C0038325

stress at work AE
type: Class
subclass of: stress AE
definition: a stress AE that results in patient experiencing stress at work
definition editor: SZ, SS, YH
has_MedDRA_id: 10042210

adverse event causality evidence from case report
type: Class
subclass of: adverse event causality evidence
definition: an adverse event causality evidence that comes from a case report.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.

subarachnoid hemorrhage AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that has an outcome of bleeding in the area between the brain and the thin tissues that cover the brain
definition editor: SZ, SS, YH
alternative term: subarachnoid haemorrhage AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001720/
has_MedDRA_id: 10042316
see also: HPO: HP_0002138
see also: SIDER: C0038525

subdural hematoma AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that has an outcome of a collection of blood on the surface of the brain
definition editor: SZ, SS, YH
alternative term: subdural haematoma AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001732/
has_MedDRA_id: 10042361
see also: HPO: HP_0100309
see also: SIDER: C0018946

gastric hemorrhage AE
type: Class
subclass of: gastrointestinal hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: A gastrointestinal hemorrhage AE that has an outcome of the bleeding in the stomach
definition editor: YH, SS
alternative term: gastric haemorrhage AE
has_MedDRA_id: 10017788
has_MedDRA_id: 10017789
see also: CTCAE: E10706
see also: NCIt: C54582

sudden death AE
type: Class
subclass of: death AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G5
definition: a death AE that has an outcome of unexpected death, 1 to 24 hours after the onset of symptoms
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/sudden+death
has_MedDRA_id: 10042434
has_MedDRA_id: 10042435
see also: CTCAE: E11171
see also: HPO: HP_0001645
see also: NCIt: C50911
see also: SIDER: C0011071

suicidal ideation AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a psychiatric disorder AE that results in thoughts about suicide
definition editor: SZ, SS, YH, MW
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Suicidal+ideation Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/10193592
has_MedDRA_id: 10042458

suicide attempt AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that results in attempted suicide
definition editor: SZ, SS, YH, MW
has_MedDRA_id: 10042464
see also: HPO: HP_0000708
see also: SIDER: C0038663

superinfection AE
type: Class
subclass of: viral infection AE
definition: a viral infection AE that has an outcome of a cell that was previously infected being coinfected with a different strain of the virus
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/superinfection
has_MedDRA_id: 10042566
see also: HPO: HP_0005364
see also: SIDER: C0038826

superior sagittal sinus thrombosis AE
type: Class
subclass of: venous thrombosis AE
definition: a venous thrombosis AE in which a stroke occurs as a result of thrombosis. uncommon cerebrovascular accident that is frequently associated with diseases that may contribute to the development of thrombosis through hypercoagulability, stasis of the local blood stream, and abnormalities of the vessel wall.
definition editor: SZ, SS, YH
alternative term: SSST
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1026412
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/1455986
has_MedDRA_id: 10042567

supraventricular extrasystoles AE
type: Class
subclass of: extrasystoles AE
definition: an arrhythmia AE that has an outcome of premature atrial contractions or beats caused by signals originating from ectopic atrial sites
definition editor: SZ, SS, YH
definition source: WEB: http://sideeffects.embl.de/se/C0033036/
has_MedDRA_id: 10042602
see also: HPO: HP_0005115
see also: SIDER: C0033036

supraventricular tachycardia AE
type: Class
subclass of: tachycardia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a tachycardia AE that has an outcome of rapid heart rhythm originating at or above the atrioventricular node
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001235/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23233691
has_MedDRA_id: 10042604
see also: CTCAE: E10218
see also: HPO: HP_0004765
see also: NCIt: C35061
see also: SIDER: C0039240

suspiciousness AE
type: Class
subclass of: adverse event
definition: Adverse event that is characterized by the patient becoming increasingly suspicious
definition editor: SZ, SS, YH
has_MedDRA_id: 10042635

suture related complication AE
type: Class
subclass of: surgery adverse event
definition: an injury and procedural complication AE that results in a complication resulting from a suture
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/17276274
has_MedDRA_id: 10059059

suture rupture AE
type: Class
subclass of: surgery adverse event
definition: a surgery AE that results in a suture being used to hold body tissues together, ruptures
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21266279
has_MedDRA_id: 10048547

tachyarrhythmia AE
type: Class
subclass of: increased heart rate AE
definition: an increased heartbeat AE that is characterized by a distburance of the heart rhythm in which heart rate is abnormally increased
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/tachyarrhythmia
has_MedDRA_id: 10049447
see also: HPO: HP_0001649
see also: SIDER: C0080203

tachycardia paroxysmal AE
type: Class
subclass of: tachycardia AE
definition: a tachycardia AE that results in tachycardia beginings and ending in an acute manner
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/11208235 Secondary Source: http://www.nlm.nih.gov/medlineplus/ency/article/000183.htm
has_MedDRA_id: 10043079

tachypnea AE
type: Class
subclass of: abnormal respiration AE
definition: an abnormal repiration AE that shows an outcome of tachypnoea (i.e., abnormally rapid breathing or respiration)
definition editor: SZ, SS, YH
alternative term: tachypnoea AE
has_MedDRA_id: 10043089
see also: HPO: HP_0004346
see also: SIDER: C0231835

adverse event causality evidence from case series
type: Class
subclass of: adverse event causality evidence
definition: an adverse event causality evidence that comes from the study of a case report series.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.

temporal lobe epilepsy AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001871
definition: Behavior and neurological AE that results in the patient having recurring seizures
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001714/
has_MedDRA_id: 10043209

graft versus host disease AE
type: Class
subclass of: immune system AE
definition: An immune system disorder AE that is a complication that can occur after a stem or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body
definition editor: YH, SS
alternative term: GVHD
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
has_MedDRA_id: 10018651

thrombocythemia AE
type: Class
subclass of: vascular disorder AE
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of too many blood platelets or thrombocytes, can result in headache, lightheadedness, vision changes and limb numbness
definition editor: SZ, SS, YH
alternative term: thrombocythaemia AE
definition source: WEB: http://www.mayoclinic.com/health/thrombocythemia/DS01087
has_MedDRA_id: 10015493

thrombocytopenia AE
type: Class
subclass of: vascular disorder AE
subclass of: hematopoietic system AE
definition: a hematopoietic system AE that has an outcome of decrease in platelets in the blood
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000586.htm
has_MedDRA_id: 10043554
see also: HPO: HP_0001873
see also: SIDER: C0040034

thrombophlebitis AE
type: Class
subclass of: phlebitis AE
definition: a phlebitis AE located in the vein, caused by a blood clot
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002098/
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001108.htm
has_MedDRA_id: 10043570
see also: HPO: HP_0004418
see also: SIDER: C0040046

thrombotic microangiopathy AE
type: Class
subclass of: thrombosis AE
definition: a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583 WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/18215115 Secondary Source: http://www.nejm.org/doi/full/10.1056/NEJMra020528
has_MedDRA_id: 10043645
see also: HPO: HP_0002597
see also: SIDER: C2717961

thyroid adenoma AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002046
definition: a tumor AE that results in a benign tumor in the thyroid
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004524/
has_MedDRA_id: 10043688
see also: HPO: HP_0000854
see also: SIDER: C0151468

thyroid mass AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002046
definition: a tumor AE that results in the patient hvings a mass growing in their thyroid
definition editor: SZ, SS, YH
has_MedDRA_id: 10058900

heart rate irregular AE
type: Class
subclass of: arrhythmia AE
definition: an arrhythmia AE that has an outcome of an irregular rate of the heartbeat
definition editor: YH, SS
has_MedDRA_id: 10019304
see also: HPO: HP_0011675
see also: SIDER: C0237314

tobacco withdrawal symptoms AE
type: Class
subclass of: syndrome AE
definition: a syndrome AE that results in the patient suffering from withdrawal from not using tobacco
definition editor: SZ, SS, YH
has_MedDRA_id: 10059612

tongue ulceration AE
type: Class
subclass of: tongue disorder
definition: a tongue AE that has an outcome of open sores or cuts on the tongue
definition editor: SZ, SS, YH
definition source: WEB: http://www.localhealth.com/article/tongue-ulcers
has_MedDRA_id: 10043991
see also: HPO: HP_0000155
see also: SIDER: C0235351

tonsil cancer AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002372
definition: Tumor AE that results in cancer in the patient's tonsils
definition editor: SZ, SS, YH
has_MedDRA_id: 10044002

tooth abscess AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of an abscess located in the tooth or a bacterial infection in the center of a tooth
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002055/
has_MedDRA_id: 10044016
see also: HPO: HP_0000164
see also: SIDER: C0518988

tooth disorder AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of disease in the teeth
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/toothdisorders.html
has_MedDRA_id: 10044034
see also: HPO: HP_0000164
see also: SIDER: C0040435

tooth fracture AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of a break or rupture in a bone
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/tooth+fracture
has_MedDRA_id: 10062544

tooth loss AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of one or more teeth coming loose and falling out
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23253824
has_MedDRA_id: 10044044
see also: HPO: HP_0006349
see also: SIDER: C0080233

toothache AE
type: Class
subclass of: bone AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a bone disorder AE that has an outcome of an aching pain in or around a tooth
definition editor: SZ, SS, YH
alternative term: odontalgia AE
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/toothache Seconday Source: http://www.ncbi.nlm.nih.gov/pubmed/22157099
has_MedDRA_id: 10044055
see also: CTCAE: E11054
see also: HPO: HP_0000164
see also: NCIt: C78640
see also: SIDER: C0040460

toxic nodular goitre AE
type: Class
subclass of: endocrine system AE
definition: a endocrine system AE that has an outcome of an excess production of thryoid hormone, characterized by functionally autonomous nodules
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000317.htm
has_MedDRA_id: 10044242

hepatic function abnormal AE
type: Class
subclass of: liver AE
definition: A liver AE that has an outcome of an abnormal functionality of the liver
definition editor: YH, SS
see also: HPO: HP_0001410
see also: SIDER: C0086565

tracheitis AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0003126
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that results in the trachea being infected by a bacteria
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001983/
has_MedDRA_id: 10044302
has_MedDRA_id: 10066798
see also: CTCAE: E11599
see also: NCIt: C78647

tracheobronchitis AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0007196
definition: a respiratory system AE that is characterized by the inflammation of the muscous membranes of the trachea and bronchi
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/tracheobronchitis
has_MedDRA_id: 10044314
see also: HPO: HP_0002837
see also: SIDER: C0040586

trance AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AEthat results in the patient being in a state of trance
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/trance
has_MedDRA_id: 10044334

transaminase level increased AE
type: Class
subclass of: transaminase level abnormal AE
definition: a transaminase level abnormal AE that has an outcome of elevated levels of alanine transaminase and aspartate transaminase
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Transaminases
has_MedDRA_id: 10054889

hypertrophic cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE
definition: A cardiomyopathy AE that has an outcome of a condition in which the heart muscle becomes thick. Often, only one part of the heart is thicker than the other parts. The thickening can make it harder for blood to leave the heart, forcing the heart to work harder to pump blood. It also can make it harder for the heart to relax and fill with blood.
definition editor: YH, SS
alternative term: HCM
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001243/
has_MedDRA_id: 10020871
see also: HPO: HP_0001639
see also: SIDER: C0007194

transposition of the great vessels AE
type: Class
subclass of: vascular disorder AE
definition: a vascular disorder AE that results in an abnormal spatial arrangement of any of the primary blood vessels
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002535/
has_MedDRA_id: 10044443

hyperchloremia AE
type: Class
subclass of: blood chloride abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood chloride increased
definition: a blood chloride abnormal AE that is characterized by an abnormally high level of chloride in the blood
definition editor: YH, MW
has_MedDRA_id: 10020599
see also: UMLS CUI: C0085679

tricuspid valve incompetence AE
type: Class
subclass of: cardiac valve disease AE
definition: a cardiac valve disease AE that is characterized by a tricuspid valve that does not close tightly enough to prevent leakage
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Tricuspid+Valve+Insufficiency
has_MedDRA_id: 10044640

tri-iodothyronine decreased AE
type: Class
subclass of: tri-iodothyronine level abnormal AE
definition: a tri-iodothyronine level abnormal AE that results in a decreased level of tri-iodothyronine
definition editor: SZ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Tri-iodothyronine
has_MedDRA_id: 10044594

troponin level increased AE
type: Class
subclass of: troponin level abnormal AE
definition: a troponin level abnormal AE that has an outcome of an increased amount of troponin, a protein released when the heart muscle is damaged
definition editor: SZ, SS, YH, EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007452.htm
has_MedDRA_id: 10058267

tuberculosis AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE that is caused by M. tuberculosis.
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001141/
has_MedDRA_id: 10044755

tumour excision
type: Class
subclass of: surgery
definition: a surgery that removes a tumour
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Tumor+Removal
has_MedDRA_id: 10061392

tumor flare AE
type: Class
subclass of: tumor AE
definition: Tumor AE that results in a tumor reoccurring
definition editor: SZ, SS, YH
alternative term: tumour flare AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21523725
has_MedDRA_id: 10045169

tumour hemorrhage AE
type: Class
subclass of: hemorrhage AE
definition: an hemorrhage AE that has an outcome of bleeding in the tumour
definition editor: SZ, SS, YH
alternative term: tumour haemorrhage AE
definition source: WEB: http://calder.med.miami.edu/pointis/tbifam/cause3.html
has_MedDRA_id: 10049750

tumor lysis syndrome AE
type: Class
subclass of: syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a syndrome AE that has an outcome of a group of metabolic complications that can occur after treatment of cancer
definition editor: SZ, SS, YH
alternative term: tumour lysis syndrome AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/15384972
has_MedDRA_id: 10045152
has_MedDRA_id: 10045170
see also: CTCAE: E12365
see also: NCIt: C3425

tumor marker increased AE
type: Class
subclass of: cytogenetic investigation result abnormal AE
definition: a cytogenetic investigation result abnormal AE that has an outcome of an increase in a substance found in the blood, urine, or body tissues that can be elevated in cancer, among other tissue types
definition editor: SZ, SS, YH, EB
alternative term: tumour marker increased AE
definition source: WEB: http://www.cancer.gov/cancertopics/factsheet/detection/tumor-markers
has_MedDRA_id: 10048621

tumor necrosis AE
type: Class
subclass of: necrosis AE
definition: a necrosis AE that has an outcome of death of tumor tissue, tumor rapidly outgrows its blood supply
definition editor: SZ, SS, YH
alternative term: tumour necrosis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/tumor+necrosis
has_MedDRA_id: 10054094

ulcerative keratitis AE
type: Class
subclass of: OAE_0003239
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a keratitis AE that has an outcome of disrupted epithelial layer and stroma of the cornea, may become blind
definition editor: SZ, SS, YH
alternative term: corneal ulcer AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Ulcerative+keratitis
has_MedDRA_id: 10064996
see also: HPO: HP_0007812
see also: SIDER: C0010043

ultrafiltration failure AE
type: Class
subclass of: homeostasis AE
definition: Homeostasis AE that results in an inability to achieve adequate fluid balance
definition editor: SZ, SS, YH
has_MedDRA_id: 10069568

upper airway obstruction AE
type: Class
subclass of: respiratory system AE
definition: Respiratory system AE that is characterized by the patient having an obstruction in their upper airway
definition editor: SZ, SS, YH
has_MedDRA_id: 10067775
see also: HPO: HP_0002781
see also: SIDER: C0740852

upper gastrointestinal hemorrhage AE
type: Class
subclass of: gastrointestinal hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a gastrointestinal hemorrhage AE that has an outcome of bleeding in the upper gastrointestinal tract
definition editor: SZ, SS, YH
alternative term: upper gastrointestinal haemorrhage AE
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/gastrointestinal+bleeding Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1237869/
has_MedDRA_id: 10046274
has_MedDRA_id: 10055356
see also: CTCAE: E11062
see also: HPO: HP_0002239
see also: NCIt: C78660
see also: SIDER: C0041909

ureteric obstruction AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE that has an outcome of a blockage in the urinary tract, can result in pain, fever, infection, loss of kidney function, sepsis or death if severe
definition editor: SZ, SS, YH
definition source: WEB: http://www.mayoclinic.org/ureteral-obstruction/
has_MedDRA_id: 10046406
see also: HPO: HP_0006000
see also: SIDER: C0041956

urethral obstruction AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000057
definition: Urinary system AE that results in the urethra becoming obstructed
definition editor: SZ, SS, YH
has_MedDRA_id: 10046459
see also: HPO: HP_0000796
see also: SIDER: C0041972

urethral stenosis AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000057
definition: Urinary System AE that results in the urethra becoming narrowed at the external meatus
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urethral+meatal+stenosis Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22710090
has_MedDRA_id: 10065584

urge incontinence AE
type: Class
subclass of: urinary incontinence AE
definition: a urinary incontinence AE that results in the patient feeling a sudden urgency or need to urinate.
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002250/
has_MedDRA_id: 10046494
see also: HPO: HP_0000012
see also: SIDER: C0150045

urinary retention AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Urinary system AE that results in an inability to urinate
definition editor: SZ, SS, YH, MW
definition source: WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urinary+retention Secondary Source: http://www.medtronic.com/patients/urinary-retention/index.htm
has_MedDRA_id: 10046555
see also: HPO: HP_0000016
see also: SIDER: C0080274

urinary tract infection pseudomonal AE
type: Class
subclass of: urinary tract infection AE
definition: a urinary tract infection AE that results in the infection of the urinary tract by the Pseudomonas Aeruginosa organism
definition editor: SZ, SS, YH
definition source: WEB: http://www.jiph.org/article/S1876-0341(09)00058-6/abstract
has_MedDRA_id: 10062279

urinary tract infection staphylococcal AE
type: Class
subclass of: urinary tract infection AE
definition: a urinary tract infection AE that results in the urinary tract being infected with the staphylococcal bacteria
definition editor: SZ, SS, YH
has_MedDRA_id: 10062280

urine amphetamine positive AE
type: Class
subclass of: toxicology drug screen result abnormal AE
definition: a toxicology drug screen result abnormal AE that results in a positive result for amphetamines in the urine
definition editor: SZ, SS, YH, EB
has_MedDRA_id: 10051400

urine output decreased AE
type: Class
subclass of: urine abnormality AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
definition: a urine abnormality AE that has an outcome of decreased urine output, less than 500 milliliters of urine in 24 hours
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003147.htm
has_MedDRA_id: 10059895
see also: CTCAE: E12217
see also: NCIt: C80522

urosepsis AE
type: Class
subclass of: urinary system AE
definition: a urinary system AE caused by an infection in the urinary tract that has an outcome of accumulation of pus-forming bacteria or toxins in the blood of the urinary tract.
definition editor: SZ, SS, YH
definition source: WEB: http://www.primehealthchannel.com/urosepsis-definition-symptoms-causes-diagnosis-and-treatment.html
has_MedDRA_id: 10048709

urticaria papular AE
type: Class
subclass of: urticaria AE
definition: an urticaria AE that results in the appearance of "wheals" on skin
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/papular+urticaria
has_MedDRA_id: 10046750

uterine contractions during pregnancy AE
type: Class
subclass of: OAE_0004304
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000995
definition: a uterine AE that results in uterine contractions during pregnancy
definition editor: SZ, SS, YH
has_MedDRA_id: 10049975

uterine hemorrhage AE
type: Class
subclass of: OAE_0004304
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000995
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a uterine AE that has an outcome of bleeding from the uterus
editor note: MedDRA: 10046788 is for "uterine haemorrhage"; MedDRA: 10046789 is for "uterine hemorrhage"
definition editor: SZ, SS, YH, MW
alternative term: uterine haemorrhage AE
has_MedDRA_id: 10046788
has_MedDRA_id: 10046789
see also: CTCAE: E13237
see also: HPO: HP_0000130
see also: NCIt: C78686
see also: SIDER: C0042134

uterine hypertonus AE
type: Class
subclass of: OAE_0004304
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000995
definition: a uterine AE that results in the patient undergoing a single uterine contraction for over two minutes during pregnancy
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488
has_MedDRA_id: 10046790
see also: HPO: HP_0000130
see also: SIDER: C0269842

vaginal infection AE
type: Class
subclass of: infection AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000996
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an infection AE that results in infection of the vagina
definition editor: SZ, SS, YH
has_MedDRA_id: 10046914
see also: CTCAE: E11624
see also: HPO: HP_0000142
see also: NCIt: C26911
see also: SIDER: C0404521

varices esophageal AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that has an outcome of dilated sub-mucosal veins in the lower third of the esophagus
definition editor: SZ, SS, YH
alternative term: varices oesophageal AE
definition source: WEB: http://www.mayoclinic.com/health/esophageal-varices/DS00820
has_MedDRA_id: 10056091
see also: HPO: HP_0002040
see also: SIDER: C0014867

vascular dementia AE
type: Class
subclass of: dementia AE
definition: a dementia AE that results in problems with reasoning, judgement, and memory resulting from brain damage from impaired blood flow to the brain
definition editor: SZ, SS, YH
definition source: WEB: http://www.mayoclinic.com/health/vascular-dementia/DS00934
has_MedDRA_id: 10057678

vein discoloration AE
type: Class
subclass of: dementia AE
definition: a vascular disorder AE that results in the veins becoming discoloured
definition editor: SZ, SS, YH
alternative term: vein discolouration AE
has_MedDRA_id: 10047183

vena cava thrombosis AE
type: Class
subclass of: thrombosis AE
definition: a thrombosis AE that has an outcome of a blood clot in the inferior vena cava
definition editor: SZ, SS, YH
alternative term: vena cava embolism AE
definition source: WEB: http://emedicine.medscape.com/article/1933035-overview, http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm
has_MedDRA_id: 10047193
has_MedDRA_id: 10047195

venous injury AE
type: Class
subclass of: dementia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a vascular disorder AE that results in an injury to the vein(s)
definition editor: SZ, SS, YH
has_MedDRA_id: 10047228
see also: CTCAE: E12051
see also: NCIt: C78711

venous thrombosis AE
type: Class
subclass of: thrombosis AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001638
definition: a thrombosis AE that has an outcome of a blood clot that forms within a vein
definition editor: SZ, SS, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm
has_MedDRA_id: 10047249
see also: HPO: HP_0004850
see also: SIDER: C0042487

ventricular dysfunction AE
type: Class
subclass of: cardiac ventricular disorder AE
definition: a cardiac ventricular disorder AE that has an outcome of an abnormality in the contraction of the ventricles or the motion of the cells
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/ventricular+dysfunction
has_MedDRA_id: 10059056

adverse event causality evidence from uncontrolled observational study
type: Class
subclass of: adverse event causality evidence
definition: an adverse event causality evidence that comes from an uncontrolled observational study
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.

vestibular neuronitis AE
type: Class
subclass of: ear AE
definition: an ear disorder that results in irritation and swelling (inflammation) of the inner ear
definition editor: SZ, SS, YH
alternative term: lybyrinthitis AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002049/
has_MedDRA_id: 10047393

vision blurred AE
type: Class
subclass of: abnormal vision AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an abnormal vision AE that results in unclear vision
definition editor: SZ, SS, YH
alternative term: blurred vision AE
definition source: WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003029.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23111613
has_MedDRA_id: 10005886
has_MedDRA_id: 10047513
see also: CTCAE: E10346
see also: HPO: HP_0000622
see also: NCIt: C27123
see also: SIDER: C0344232

visual acuity reduced AE
type: Class
subclass of: abnormal vision AE
definition: an abnormal vision AE that results in a decrease in clearness of vision
definition editor: SZ, SS, YH
definition source: WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003396.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23329671
has_MedDRA_id: 10047531
see also: HPO: HP_0000572
see also: SIDER: C0234632

visual brightness AE
type: Class
subclass of: abnormal vision AE
definition: an abnormal vision AE that results in the patient suffering from an enhanced brightness in their vision
definition editor: SZ, SS, YH
has_MedDRA_id: 10049155

vitamin d deficiency AE
type: Class
subclass of: gustatory system AE
definition: a gustatory system AE that has an outcome of a shortage of vitamin D which is essential for strong bones
definition editor: SZ, SS, YH
definition source: WEB: http://www.webmd.com/diet/vitamin-d-deficiency
has_MedDRA_id: 10047626
see also: HPO: HP_0100513
see also: SIDER: C0042870

adverse event causality evidence from controlled observational study
type: Class
subclass of: adverse event causality evidence
definition: an adverse event causality evidence that comes from controlled observational studies.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 29.

vitritis AE
type: Class
subclass of: inflammation AE
definition: Inflammation AE that is characterized by an inflammatory reaction of the vitreous or hyaloid membrane as a result of disease in adjacent structures
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/vitritis
has_MedDRA_id: 10047663

weight increased AE
type: Class
subclass of: physical examination result abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a physical examination result abnormal AE that shows an increase (gain) in weight of a patient
definition editor: SZ, SS, YH
alternative term: weight gain AE
has_MedDRA_id: 10047896
has_MedDRA_id: 10047899
see also: CTCAE: E12224
see also: HPO: HP_0004324
see also: NCIt: C62754
see also: SIDER: C0043094

wolff-parkinson-white syndrome AE
type: Class
subclass of: conduction system disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a conduction system disorder AE that results in an abnormal accessory electrical conduction pathway between the atria and ventricles
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001206/
has_MedDRA_id: 10048015
see also: CTCAE: E10244
see also: NCIt: C35132

wound complication AE
type: Class
subclass of: wound AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a wound AE that has an outcome of complication to the wound
definition editor: SZ, SS, YH
definition source: WEB: https://en.wikipedia.org/wiki/Wound
has_MedDRA_id: 10053692
see also: CTCAE: E12057
see also: NCIt: C78719

wound dehiscence AE
type: Class
subclass of: wound AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a wound AE that has an outcome of a wound breaking open along the surgical sutures
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/wound+dehiscence
has_MedDRA_id: 10048031
see also: CTCAE: E12063
see also: NCIt: C50863

wound secretion AE
type: Class
subclass of: wound AE
definition: A wound AE that has an outcome of secretions or pus produced by damaged tissue particles and repairing mechanisms intitiated by the body
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/2815962
has_MedDRA_id: 10048629

xanthopsia AE
type: Class
subclass of: abnormal vision AE
definition: an abnormal vision AEthat results in the patient seeing a predominance of yellow in their vision
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/xanthopsia
has_MedDRA_id: 10048216
see also: HPO: HP_0000551
see also: SIDER: C0221185

zygomycosis AE
type: Class
subclass of: immune system AE
definition: an immune system disorder AE that results in a fungal infection of the sinuses, brain, or lungs that occurs in some people with a weakened immune system
definition editor: SZ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001672/
has_MedDRA_id: 10061418

ischemic cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE
definition: A cardiomyopathy AE that has an outcome of a heart failure with left ventricular dilatation resulting from ischemic heart disease.
definition editor: YH, SS
alternative term: ischaemic cardiomyopathy AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/ischemic+cardiomyopathy
has_MedDRA_id: 10048858

jaw operation
type: Class
subclass of: surgery
definition: A surgery that is a procedure performed on the jaw
definition editor: YH, SS
has_MedDRA_id: 10059242

narcolepsy AE
type: Class
subclass of: nervous system AE
definition: An adverse event that is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally.
definition editor: YL
definition source: http://en.wikipedia.org/wiki/Narcolepsy
creator: YL

mechanical ventilation
type: Class
subclass of: medical intervention
definition: A medical intervention that is a life-support system designed to replace or support normal ventilatory lung function
definition editor: YH, SS
definition source: WEB: www.medscape.com/resource/mechanical-ventilation
has_MedDRA_id: 10067221

mucosal inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: An inflammation AE that has an outcome of tissue swelling and other inflammatory response in the mouth
definition editor: YH, SS
alternative term: oral mucositis
has_MedDRA_id: 10028116
has_MedDRA_id: 10028130
see also: CTCAE: E10872
see also: NCIt: C26887

multi-organ failure AE
type: Class
subclass of: systematic AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: A systematic adverse event that has an outcome of failure in mulitple organs
definition editor: YH, SS
has_MedDRA_id: 10028154
see also: CTCAE: E11155
see also: NCIt: C75568

pleomorphic rash AE
type: Class
subclass of: rash AE
definition: Pleomorphic rash AE is rash AE that is a rash characterized by many-formed.
definition editor: JX, LW, YH
Chinese translation: 多形性皮疹

osteoporosis AE
type: Class
subclass of: bone AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: A bone disorder AE that has an outcome of the weakening or brittle bone
definition editor: YH, SS, MW
definition source: WEB: http://www.mayoclinic.com/health/osteoporosis/DS00128
has_MedDRA_id: 10031282
see also: HPO: HP_0000939
see also: SIDER: C0029456

Mendelian susceptibility to mycobacterial disease
type: Class
subclass of: bacterial infection AE
definition: A groupd of disroders where the genetic susceptibility plays an important role to the seletctive susceptibility to poorly pathogenic mycobacterial species such as bacille Calmette-Guérin and environmental mycobacteria.
alternative term: MSMD
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20718793
creator: YL

restrictive cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: A cardiomyopathy AE that has an outcome of a condition that the heart cannot relax normally during the time between heartbeats when the blood returns from the body (diastole).
definition editor: YH, SS
alternative term: infiltrative cardiomyopathy
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000189.htm
has_MedDRA_id: 10038748
see also: CTCAE: E10192
see also: NCIt: C62798

stem cell transplant
type: Class
subclass of: medical intervention
definition: A medical intervention that has an outcome of the transplant of stem cells into the body
definition editor: YH, SS
has_MedDRA_id: 10063581

adverse event causality evidence from controlled clinical trial
type: Class
subclass of: adverse event causality evidence
definition: an adverse event causality evidence that comes from a controlled clincal trial
editor note: In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30.

stent placement
type: Class
subclass of: medical intervention
definition: A medical intervention that has an outcome of an intersion of a tube into the body
definition editor: YH, SS
has_MedDRA_id: 10048561

stress cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE
definition: A cardiomyopathy AE that is a temporary heart condition brought on by stressful situations, such as the death of a loved one. People with broken heart syndrome may have sudden chest pain or think they're having a heart attack. These broken heart syndrome symptoms may be brought on by the heart's reaction to a surge of stress hormones. In broken heart syndrome, a part of your heart temporarily enlarges and doesn't pump well, while the remainder of the heart functions normally or with even more forceful contractions.
definition editor: YH, SS
alternative term: takotsubo cardiomyopathy, broken heart syndrome, stress-induced cardiomyopathy, apical ballooning syndrome
definition source: WEB: http://www.mayoclinic.com/health/broken-heart-syndrome/DS01135/METHOD=print
has_MedDRA_id: 10066286

tooth extraction
type: Class
subclass of: medical intervention
definition: A medical intervention that has an outcome of an extraction of the tooth
definition editor: YH, SS
has_MedDRA_id: 10062132

toxic skin eruption AE
type: Class
subclass of: skin AE
definition: A skin adverse event that has an outcome of an eruption caused by ingestion, injection, inhalation, or insertion of a drug, often a result of allergic sensitization. Also called dermatitis medicamentosa, dermatosis medicamentosa, drug rash
definition editor: YH, SS
alternative term: dermatitis medicamentosa, dermatosis medicamentosa, drug rash
definition source: WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption
has_MedDRA_id: 10057970

ventricular fibrillation AE
type: Class
subclass of: arrhythmia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: An arrythmia AE that has an outcome of a severely abnormal heart rhythm (arrhythmia) that can be life-threatening.
definition editor: YH, SS
alternative term: VF
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004467/
has_MedDRA_id: 10047290
see also: CTCAE: E10236
see also: HPO: HP_0001663
see also: NCIt: C50799
see also: SIDER: C0042510

first degree atrioventricular block AE
type: Class
subclass of: atrioventricular block AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: an atrioventricular block AE that there is some prolongation of AV conduction time (PR interval). The heart's electrical signals are slowed as they move from the atria to the ventricles (the heart's upper and lower chambers, respectively). This results in a longer, flatter line between the P and the R waves on the EKG (electrocardiogram).
definition editor: SS
alternative term: atrioventricular block first degree
alternative term: first degree heart block
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
has_MedDRA_id: 10003674
see also: CTCAE: E10098
see also: NCIt: C62015

wound debridement
type: Class
subclass of: medical intervention
definition: A medical intervention that has an outcome of the removal of dead, damaged, dying or infected tissue. The human body is capable of (autolytic) debridement for small wounds, but for large wounds, medical procedures are necessary.
definition editor: YH, SS
alternative term: surgical debridement, enzymatic debridement, autolytic debridement, mechanical debridement
definition source: WEB: http://surgery.about.com/od/glossaryofsurgicalterms/g/Debridement.htm
has_MedDRA_id: 10048030

subacute thyroiditis AE
type: Class
subclass of: thyroiditis AE
definition: A thyroiditis AE that shows a self-limited thyroid condition associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function.
definition editor: YL, YH
alternative term: SAT
alternative term: painless thyroiditis AE
alternative term: silent thyroiditis AE
definition source: http://emedicine.medscape.com/article/125648-overview
definition source: https://en.wikipedia.org/wiki/Subacute_lymphocytic_thyroiditis

macrophagic myofasciitis AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: Macrophagic myofasciitis (MMF) is a rare inflammatory muscle disorder characterized by a characteristic infiltration of muscle tissue by PAS-positive macrophages, which is caused by pathological persistence of vaccine-derived aluminium hydroxide. The diagnosis can only be established by an open muscle biopsy from the muscle that was used for intramuscular vaccination.
definition editor: YL
alternative term: MMF
definition source: http://www.ncbi.nlm.nih.gov/pubmed/14593574
creator: YL

disseminated BCG infection AE
type: Class
subclass of: bacterial infection AE
definition: BCG infection following BCG injection. It is often related with the vaccinee's immunodeficiency.
definition editor: YL
creator: YL

autism AE
type: Class
subclass of: nervous system AE
definition: An adverse event that is a disorder of neural development characterized by impaired social interaction and communication, and by restricted and repetitive behavior.
definition editor: YL
definition source: http://en.wikipedia.org/wiki/Autism
see also: HPO: HP_0000717
see also: SIDER: C0004352

autoimmune encephalitis AE
type: Class
subclass of: autoimmune disorder AE
definition: an adverse event that is a type of encephalitis triggered by vaccination.
elucidation: Autoimmune Encephalitis may be triggered by infection in which case the term "Post-infectious Encephalitis" is used. ADEM( Acute Disseminated Encephalomyelitis ) is a Post-infectious Encephalitis. The illness usually follows in the wake of a mild viral infection (such as those that cause rashes in childhood) or immunisations. Typically there is a delay of days to two to three weeks between the triggering infection and development of the encephalitis. It has recently been recognised that there are other types of Autoimmune Encephalitis resulting from an attack of the brain by the body's immune system. Some of these types of autoimmune encephalitis are identified by finding a specific antibody in blood. These conditions include Potassium channel complex antibody associated encephalitis, NMDAR and Hashimoto's encephalitis. http://www.encephalitis.info/information/the-illness/types-of-autoimmune-encephalitis/
creator: YL

injection-site redness AE
type: Class
subclass of: injection-site AE
definition: an injection-site AE that display an redness in the injection-site
definition editor: YH

injection-site tenderness AE
type: Class
subclass of: injection-site AE
subclass of: sensory capability AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: a sensory capability AE that shows up skin tenderness and occurs in an injection site of a medical intervention
definition editor: YH
has_MedDRA_id: 10043224

arm motion limitation AE
type: Class
subclass of: movement disorder AE
definition editor: YH
comment: a movement disorder AE that has an outcome of arm motion limitation

injection-site muscular soreness AE
type: Class
subclass of: injection-site AE
subclass of: sensory capability AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: a sensory capability AE that shows up muscular soreness at the injection site of a medical intervention
definition editor: YH
has_MedDRA_id: 10028332

sleepiness AE
type: Class
subclass of: sleep disorder AE
definition: a sleep disorder AE that shows up sleepiness (Sluggish from sleep, inactive, quiet).
definition editor: YH
has_MedDRA_id: 10041014

brain AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: occurs in
    some values from: UBERON_0000955
subclass of: adverse event
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
definition: an adverse event that occurs in brain.
definition editor: YH
alternative term: brain disorder AE

mild hypersensitivity AE
type: Class
subclass of: hypersensitivity AE
definition: a hypersensitivity AE that is mild.
definition editor: YH

injection-site arm edema AE
type: Class
subclass of: injection-site edema AE
definition editor: YH
definition editor: an injection-site edema AE that occurs in the arm.

restlessness AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a psychiatric disorder AE that shows restlessness
definition editor: YH, MW
definition source: WEB: http://dictionary.reference.com/browse/restlessness
has_MedDRA_id: 10038743
see also: UMLS_CUI: C0085631

induration with tenderness AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that results in a sensation of induration with tenderness.
definition editor: YH

fussiness AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that results in a sensation of fussiness
definition editor: YH

decreased sleep AE
type: Class
subclass of: sleep disorder AE
definition: a sleep disorder AE that shows decreased sleep
definition editor: YH

increased sleep AE
type: Class
subclass of: sleep disorder AE
definition: a sleep disorder AE that shows increased sleep
definition editor: YH

joint pain AE
type: Class
subclass of: pain AE
definition: a pain AE that occurs at a joint
definition editor: YH

tiredness AE
type: Class
subclass of: sensory capability AE
definition: Tiredness AE is a sensory capability AE that results in a sensation of tiredness.
editor note: This term appears to be a synonym to the 'fatigue AE'.
definition editor: JX, LW, YH
alternative term: hypodynamia AE
Chinese translation: 疲劳/乏力
has_MedDRA_id: 10043890

nasal discomfort AE
type: Class
subclass of: respiratory system AE
definition: nasal discomfort AE is a respiratory system AE that shows a discomfort from the nose
definition editor: YH
see also: HPO: HP_0010640
see also: SIDER: C0858259

adverse event causality P-value
type: Class
subclass of: adverse event causality score
definition: an adverse event causal associate score that represents a statatical P-value to address the causal adverse event hypothesis.
definition editor: YH

proportional reporting ratio
type: Class
subclass of: data item
definition: a data item that represents a statistic to summarize the extent to which a particular adverse event is observed for individuals taking a specific medical intervention (e.g., a drug), compared to the frequency at which the same adverse event occurs for patients taking some other intervention (e.g., other drug or any drug in a specified class of drugs).
editor note: The PRR will typically be calculated using a surveillance database in which reports of adverse events from a variety of drugs are recorded.
definition editor: YH
alternative term: PRR
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/11828828

P-value of adverse event causality Chi-square test
type: Class
subclass of: adverse event causality P-value
definition: an adverse event causality P-value that is calculated out of a specific Chi-square test.
definition editor: YH

adverse event filtering cutoff
type: Class
subclass of: data item
definition: a data item that represents a threshold cutoff for filtering out those adverse event case reports that are unlikely important for a specific AE study. This is applied to the analysis of AE case resport data in an AE case reporting system such as FAERS or VAERS.
definition editor: YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23209624

AE prevalence rate
type: Class
subclass of: data item
definition: A data item that is defined as the number of patients realized with an adverse event beginning in an interval or continuing from a previous interval divided by the number of patients taking the same medical intervention within that interval. The prevalence thus indicates the number of events that began and persisted over time.
definition editor: AG, YH
definition source: WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf

nuclear magnetic resonance imaging result abnormal AE
type: Class
subclass of: imaging investigation result abnormal AE
definition: an imaging investigation result abnormal AE that is indicated by an abnormal result of a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body
definition editor: EB
has_MedDRA_id: 10029816

computerized tomogram with contrast abnormal AE
type: Class
subclass of: computerized tomography result abnormal AE
definition: a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body using a dye, called oral contrast, that shows up on the CT images to help better define internal organs
definition editor: EB
alternative term: computerised tomogram with contrast abnormal AE

computerized tomogram without contrast abnormal AE
type: Class
subclass of: computerized tomography result abnormal AE
definition: a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body
definition editor: EB
alternative term: computerised tomogram without contrast abnormal AE

cardiovascular investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0004535
definition: an investigation result abnormal AE that involves an abnormal result of an investigation involving the cardiovascular system
definition editor: EB, YH
has_MedDRA_id: 10007512

second degree atrioventricular block AE
type: Class
subclass of: atrioventricular block AE
definition: an atrioventricular block AE that some but not all atrial impulses fail to reach the ventricles, thus some ventricular beats are dropped. Electrical signals between the atria and ventricles are slowed to a large degree. Some signals don't reach the ventricles. On an EKG, the pattern of QRS waves doesn't follow each P wave as it normally would.
definition editor: SS
alternative term: atrioventricular block second degree
alternative term: second degree heart block
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
has_MedDRA_id: 10003677

echocardiogram result abnormal AE
type: Class
subclass of: cardiovascular investigation result abnormal AE
definition: a cardiac and vascular investigation result abnormal AE that is an abnormal result of a test that uses sound waves to create a moving picture of the heart
definition editor: EB
has_MedDRA_id: 10061593

electrolyte lab test abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal electrolyte value
definition editor: EB
has_MedDRA_id: 10047843

blood phosphorus abnormal AE
type: Class
subclass of: electrolyte blood test abnormal AE
definition: an electrolyte lab test abnormal AE that shows an abnormal blood phosphorus level
definition editor: EB
has_MedDRA_id: 10054823

blood phosphorus increased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an increased level of phosphate in the blood
definition editor: EB, YH, MW
has_MedDRA_id: 10050196
see also: HPO: HP_0002905
see also: SIDER: C0919625

complete atrioventricular block AE
type: Class
subclass of: atrioventricular block AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an atrioventricular block AE that complete atrioventricular dissociation occurs; atria and ventricles beat independently. None of the electrical signals reach the ventricles. This type also is called complete heart block or complete AV block. When complete heart block occurs, special areas in the ventricles may create electrical signals to cause the ventricles to contract. This natural backup system is slower than the normal heart rate and isn't coordinated with the contraction of the atria. On an EKG, the normal pattern is disrupted. The P waves occur at a faster rate that isn't coordinated with the QRS waves.
definition editor: SS
alternative term: atrioventricular block complete
alternative term: complete heart block
alternative term: third degree atrioventricular block
alternative term: third degree heart block
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
has_MedDRA_id: 10003673
see also: CTCAE: E10093
see also: NCIt: C50501

blood potassium abnormal AE
type: Class
subclass of: electrolyte blood test abnormal AE
definition: an electrolyte lab test abnormal AE that results in an abnormal level of potassium in the blood
definition editor: EB
has_MedDRA_id: 10005722
see also: HPO: HP_0011042
see also: SIDER: C0853759

blood potassium increased
type: Class
subclass of: PATO_0001018
definition: a physical quality where the blood potassium level is increased.
definition editor: EB, YH, MW
alternative term: hyperkalemia AE
has_MedDRA_id: 10005725
see also: HPO: HP_0002513
see also: SIDER: C0853760

blood sodium abnormal AE
type: Class
subclass of: electrolyte blood test abnormal AE
definition: an electrolyte lab test abnormal AE that results in an abnormal level of sodium in the blood
definition editor: EB
has_MedDRA_id: 10005800

blood sodium increased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an increased level of sodium in the blood
definition editor: EB, YH, MW
has_MedDRA_id: 10005803
see also: HPO: HP_0003228
see also: SIDER: C0595878

blood magnesium abnormal AE
type: Class
subclass of: electrolyte blood test abnormal AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002390
definition: an electrolyte lab test abnormal AE that results in an abnormal level of magnesium in the blood
definition editor: EB
has_MedDRA_id: 10005652

blood magnesium increased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an increased level of magnesium in the blood
definition editor: EB, YH, MW
has_MedDRA_id: 10005655

blood chloride abnormal AE
type: Class
subclass of: electrolyte blood test abnormal AE
definition: an electrolyte lab test abnormal AE that results in an abnormal level of chloride in the blood
definition editor: EB
has_MedDRA_id: 10005417

blood chloride increased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an increased level of chloride in the blood
definition editor: EB
has_MedDRA_id: 10005420

blood calcium abnormal AE
type: Class
subclass of: electrolyte blood test abnormal AE
definition: an electrolyte lab test abnormal AE that results in an abnormal level of calcium in the blood
definition editor: EB
has_MedDRA_id: 10005393

blood calcium increased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an increased level of calcium in the blood
definition editor: EB, YH, MW
has_MedDRA_id: 10005396

urinary system investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0001008
definition: an investigation result abnormal AE that involves the renal and urinary tract and urinalyses
definition editor: EB, YH
alternative term: renal and urinary tract investigation and urinalysis result abnormal AE
alternative term: renal system investigation result abnormal AE
has_MedDRA_id: 10038362

blood creatinine level abnormal AE
type: Class
subclass of: urinary system investigation result abnormal AE
definition: a urinary system investigation result abnormal AE that is characterized by an abnormal level of creatinine in the blood
definition editor: EB
has_MedDRA_id: 10005481

blood urea level abnormal AE
type: Class
subclass of: urinary system investigation result abnormal AE
definition: a urinary system investigation result abnormal AE that is characterized by an abnormal level of urea in the blood
definition editor: EB
has_MedDRA_id: 10005846

lipid analysis result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal result of a lipid analyses
definition editor: EB
has_MedDRA_id: 10024580

blood cholesterol abnormal AE
type: Class
subclass of: lipid analysis result abnormal AE
definition: a lipid analysis result abnormal AE that results in an abnormal blood cholesterol level
definition editor: EB
has_MedDRA_id: 10005423

blood cholesterol decreased AE
type: Class
subclass of: blood cholesterol abnormal AE
definition: a blood cholesterol abnormal AE that results in a decreased amount of cholesterol in the blood
definition editor: EB
has_MedDRA_id: 10005424

high density lipoprotein abnormal AE
type: Class
subclass of: lipid analysis result abnormal AE
definition: a lipid analysis result abnormal AE that is characterized by an abnormal amount of high density lipoprotein
definition editor: EB
has_MedDRA_id: 10020051

high density lipoprotein increased AE
type: Class
subclass of: high density lipoprotein abnormal AE
definition: a high density lipoprotein abnormal AE that is characterized by an increased amount of high density lipoprotein
definition editor: EB
has_MedDRA_id: 10020061

high density lipoprotein decreased AE
type: Class
subclass of: high density lipoprotein abnormal AE
definition: a high density lipoprotein abnormal AE that is characterized by a decreased amount of high density lipoprotein
definition editor: EB
has_MedDRA_id: 10020060
see also: HPO: HP_0003233
see also: SIDER: C0151691

low density lipoprotein abnormal AE
type: Class
subclass of: lipid analysis result abnormal AE
definition: a lipid analysis result abnormal AE that is characterized by an abnormal amount of low density lipoprotein
definition editor: EB
has_MedDRA_id: 10024901

low density lipoprotein increased AE
type: Class
subclass of: low density lipoprotein abnormal AE
definition: a low density lipoprotein abnormal AE that is characterized by an increased amount of low density lipoprotein
definition editor: EB
has_MedDRA_id: 10024910
see also: HPO: HP_0003141
see also: SIDER: C0549399

low density lipoprotein decreased AE
type: Class
subclass of: low density lipoprotein abnormal AE
definition: a low density lipoprotein abnormal AE that is characterized by a decreased amount of low density lipoprotein
definition editor: EB
has_MedDRA_id: 10024909

blood triglycerides abnormal AE
type: Class
subclass of: lipid analysis result abnormal AE
definition: a lipid analysis result abnormal AE that is characterized by an abnormal amount of triglycerides in the blood
definition editor: EB
has_MedDRA_id: 10005837

blood triglycerides increased AE
type: Class
subclass of: blood triglycerides abnormal AE
definition: a blood triglycerides abnormal AE that is characterized by an increased amount of triglycerides in the blood
definition editor: EB
has_MedDRA_id: 10005839
see also: HPO: HP_0002155
see also: SIDER: C0853692

blood triglycerides decreased AE
type: Class
subclass of: blood triglycerides abnormal AE
definition: a blood triglycerides abnormal AE that is characterized by a decreased amount of triglycerides in the blood
definition editor: EB
has_MedDRA_id: 10005838

immunology and allergy investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal result for an immunology and allergy investigation
definition editor: EB
has_MedDRA_id: 10021505

Mobitz type I block AE
type: Class
subclass of: second degree atrioventricular block AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a second degree atrioventricular block AE that the electrical signals are delayed more and more with each heartbeat, until the heart skips a beat. On the EKG, the delay is shown as a line (called the PR interval) between the P and QRS waves. The line gets longer and longer until the QRS waves don't follow the next P wave.
editor note: MedDRA: 10050797 is a LLT for type I second degree atrioventricular block MedDRA (LLT): 10047909 exists for Wenckebach phenomeono MedDRA (LLT): 10047908 exists for Wenchebach MedDRA (LLT): 10027787 for Mobit type I
definition editor: SS, MW, YH
alternative term: Mobitz type 1 block
alternative term: Wenckebach Phenomenon
alternative term: Wenckebach's block
alternative term: type 1 second degree atrioventricular block
alternative term: type I second degree atrioventricular block
definition source: WEB: https://www.nhlbi.nih.gov/health/health-topics/topics/hb/types
has_MedDRA_id: 10027787
has_MedDRA_id: 10047908
has_MedDRA_id: 10047909
has_MedDRA_id: 10050797
see also: CTCAE: E10146
see also: NCIt: C62017

Epstein-Barr virus antibody positive AE
type: Class
subclass of: immunology and allergy investigation result abnormal AE
definition: an immunology and allergy investigation result abnormal AE that is characterized by antibodies for epstein barr virus being detected
definition editor: EB
has_MedDRA_id: 10056906

microbiology and serology investigation result abnormal AE
type: Class
subclass of: immunology and allergy investigation result abnormal AE
definition: an immunology and allergy investigations result abnormal AE that is characterized by an abnormal microbiology and serology investigation
definition editor: EB
has_MedDRA_id: 10027529

CSF culture positive AE
type: Class
subclass of: microbiology and serology investigation result abnormal AE
definition: a microbiology and serology investigation result abnormal AE that is characterized by a positive CSF culture
definition editor: EB
has_MedDRA_id: 10011529

metabolic and nutritional investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal result of a metabolic and nutritional investigation
definition editor: EB
has_MedDRA_id: 10027432

glycosylated hemoglobin level abnormal AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
definition: a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal glycosylated hemoglobin level
definition editor: EB
has_MedDRA_id: 10055587

glycosylated hemoglobin level increased AE
type: Class
subclass of: glycosylated hemoglobin level abnormal AE
definition: a glycosylated hemoglobin level abnormal AE that is charaterized by an increased glycosylated hemoglobin level
definition editor: EB
has_MedDRA_id: 10055587

abdomen crushing AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
subclass of: accidental injury AE
definition: This is an AE which is a symptom associated with both non-serious and serious medical issues.
definition: a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood folate level
definition editor: EB
definition editor: QY, JX, HY
definition source: http://en.volupedia.org/wiki/Abdominal_pain
Chinese translation: 腹挤压伤
has_MedDRA_id: 10000044
has_MedDRA_id: 10005525
label: blood folate level abnormal AE

blood folate level increased AE
type: Class
subclass of: abdomen crushing AE
definition: a blood folate abnormal AE that is charaterized by an increased blood folate level
definition editor: EB
has_MedDRA_id: 10005528

blood glucose level abnormal AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
definition: a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood glucose level
definition editor: EB
has_MedDRA_id: 10005554

blood homocysteine level abnormal AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
definition: a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood homocysteine
definition editor: EB
has_MedDRA_id: 10049735

blood homocysteine level decreased AE
type: Class
subclass of: blood homocysteine level abnormal AE
definition: a blood homocysteine level abnormal AE that is charaterized by a decreased blood homocysteine
definition editor: EB
has_MedDRA_id: 10049734

blood uric acid level abnormal AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
definition: a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood uric acid level
definition editor: EB
has_MedDRA_id: 10061727

blood uric acid level decreased AE
type: Class
subclass of: blood uric acid level abnormal AE
definition: a blood uric acid level abnormal AE that is characterized by a decreased blood uric acid
definition editor: EB
has_MedDRA_id: 10005860

vitamin B12 level abnormal AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
definition: a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal vitamin B12 level
definition editor: EB
has_MedDRA_id: 10062187

vitamin B12 level increased AE
type: Class
subclass of: vitamin B12 level abnormal AE
definition: a vitamin B12 level abnormal AE that is characterized by an increased vitamin B12 level
definition editor: EB
has_MedDRA_id: 10047610

vitamin B12 level decreased AE
type: Class
subclass of: vitamin B12 level abnormal AE
definition: a vitamin B12 level abnormal AE that is characterized by a decreased vitamin B12 level
definition editor: EB
has_MedDRA_id: 10047608

brain natriuretic peptide level abnormal AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
definition: a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal brain natriuretic peptide level
definition editor: EB
has_MedDRA_id: 10053408

brain natriuretic peptide level increased AE
type: Class
subclass of: brain natriuretic peptide level abnormal AE
definition: a brain natriuretic peptide level abnormal AE that is characterized by an increased brain natriuretic peptide level
definition editor: EB
has_MedDRA_id: 10053405

brain natriuretic peptide level decreased AE
type: Class
subclass of: brain natriuretic peptide level abnormal AE
definition: a brain natriuretic peptide level abnormal AE that is characterized by a decreased brain natriuretic peptide level
definition editor: EB
has_MedDRA_id: 10053407

blood gas investigation result abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that involves an abnormal result of the oxygen and carbon dioxide content of arterial blood, measured by various methods to assess the adequacy of ventilation and oxygenation and the acid-base status of the body
definition editor: EB, SJ
definition source: WEB: http://medical-dictionary.thefreedictionary.com/arterial+blood+gas
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003855.htm
has_MedDRA_id: 10005539
has_MedDRA_id: 10027432
comment: blood gases abnormal AE may be a result of lung, kidney, or metablolic diseases or the result of abnormal breathing after a head or neck injur

carbon dioxide abnormal AE
type: Class
subclass of: blood gas investigation result abnormal AE
definition: a blood gas investigation result abnormal AE that is characterized by an abnormal amount of carbon dioxide in the blood
definition editor: EB
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003469.htm
has_MedDRA_id: 10064156

carbon dioxide increased AE
type: Class
subclass of: carbon dioxide abnormal AE
definition: a carbon dioxide abnormal AE that is characterized by an increased carbon dioxide level in the blood
definition editor: EB
has_MedDRA_id: 10007225
see also: HPO: HP_0005972
see also: SIDER: C0860713

blood pH abnormal AE
type: Class
subclass of: blood gas investigation result abnormal AE
definition: a blood gas investigation result abnormal AE that is characterized by an abnormal acidity or alkalinity of blood
definition editor: EB
definition source: WEB: http://www.medterms.com/script/main/art.asp?articlekey=10001
has_MedDRA_id: 10005705

blood pH increased AE
type: Class
subclass of: blood pH abnormal AE
definition: a blood pH abnormal AE that is characterized by an increased blood pH
definition editor: EB
has_MedDRA_id: 10005708

hernial eventration AE
type: Class
subclass of: abdominal AE
subclass of: blood pH abnormal AE
definition: This is an AE which is the protrusion of contents of the abdomen through a defect or weakness in the abdominal wall.
definition: a blood pH abnormal AE that is characterized by a decreased blood pH
definition editor: EB
definition editor: QY, JX, HY
definition source: http://en.volupedia.org/wiki/Eventration
Chinese translation: 疝腹脏突出
has_MedDRA_id: 10005706
has_MedDRA_id: 10057391
label: blood pH decreased AE

adverse event causality evidence from combined sources
type: Class
subclass of: adverse event causality evidence
definition: an adverse event causality evidence that comes from the combined evidence sources
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.

oxygen saturation abnormal AE
type: Class
subclass of: blood gas investigation result abnormal AE
definition: a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen saturation in the blood
definition editor: EB
has_MedDRA_id: 10033317

oxygen saturation increased AE
type: Class
subclass of: oxygen saturation abnormal AE
definition: an oxygen saturation abnormal AE that is characterized by an increased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen
definition editor: EB
has_MedDRA_id: 10033320

PCO2 abnormal AE
type: Class
subclass of: blood gas investigation result abnormal AE
definition: a blood gas investigation result abnormal AE that is characterized by an abnormal carbon dioxide partial pressure or tension in the blood
definition editor: EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/PCO2
has_MedDRA_id: 10058982

PCO2 increased AE
type: Class
subclass of: PCO2 abnormal AE
definition: a PCO2 abnormal AE that is characterized by an increased carbon dioxide partial pressure or tension in the blood
definition editor: EB
has_MedDRA_id: 10034183

PCO2 decreased AE
type: Class
subclass of: PCO2 abnormal AE
definition: a pPCO2 abnormal AE that is characterized by a decreased carbon dioxide partial pressure or tension in the blood
definition editor: EB
has_MedDRA_id: 10034181

abdominal adhesions AE
type: Class
subclass of: blood gas investigation result abnormal AE
subclass of: adhesion AE
definition: This is an AE which is most commonly caused by abdominal surgical procedures and the adhesions start to form within hours of surgery and may cause internal organs to attach to other organs in the abdominal cavity.
definition: a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen partial pressure in the blood
definition editor: EB
definition editor: QY, JX, HY
definition source: WEB: http://medical-dictionary.thefreedictionary.com/PO2
definition source: http://en.volupedia.org/wiki/Adhesion_(medicine)#Abdominal_adhesions
Chinese translation: 腹部粘连
has_MedDRA_id: 10000050
has_MedDRA_id: 10062087
label: PO2 abnormal AE

PO2 increased AE
type: Class
subclass of: abdominal adhesions AE
definition: a PO2 abnormal AE that is characterized by an increased oxygen partial pressure in the blood
definition editor: EB
has_MedDRA_id: 10035769

PO2 decreased AE
type: Class
subclass of: abdominal adhesions AE
definition: a PO2 abnormal AE that is characterized by a decreased oxygen partial pressure in the blood
definition editor: EB
has_MedDRA_id: 10035768

toxicology drug screen result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that results from an abnormal toxicology screen
definition editor: EB
has_MedDRA_id: 10044260

barbiturates positive AE
type: Class
subclass of: toxicology drug screen result abnormal AE
definition: a toxicology drug screen result abnormal AE that is characterized by positive barbiturates
definition editor: EB
has_MedDRA_id: 10063230

cocaine positive AE
type: Class
subclass of: toxicology drug screen result abnormal AE
definition: a toxicology drug screen result abnormal AE that is characterized by positive cocaine
definition editor: EB
has_MedDRA_id: 10063230

Mobitz type II block AE
type: Class
subclass of: second degree atrioventricular block AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a second degree atrioventricular block AE that some of the electrical signals don't reach the ventricles. However, the pattern is less regular than it is in Mobitz type I. Some signals move between the atria and ventricles normally, while others are blocked. On an EKG, the QRS wave follows the P wave at a normal speed. Sometimes, though, the QRS wave is missing (when a signal is blocked).
definition editor: SS, YH, MW
alternative term: Mobitz (type) II atrioventricular block AE
alternative term: Mobitz type 2 block
alternative term: type 2 second degree atrioventricular block
alternative term: type II second degree atrioventricular block
definition source: WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
has_MedDRA_id: 10027786
has_MedDRA_id: 10050798
see also: CTCAE: E10140
see also: NCIt: C62018

urine cannabinoids increased AE
type: Class
subclass of: toxicology drug screen result abnormal AE
definition: a toxicology drug screen result abnormal AE that is characterized by increased urine cannabinoids
definition editor: EB
has_MedDRA_id: 10062228

behavioral and neurological test abnormal AE
type: Class
subclass of: investigation result abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: OAE_0003230
definition: an investigation result abnormal AE that involves an abnormal result of a neurological, special senses and psychiatric investigation
definition editor: EB
alternative term: neurological, special senses and psychiatric investigation result abnormal AE
has_MedDRA_id: 10029295

physical examination result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE resulting from an abnormal physical examination finding
definition editor: EB
has_MedDRA_id: 10062078
has_MedDRA_id: 10071940

cytogenetic investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal result of an investigation related to chromosomal abnormalities and pathologic conditions
definition editor: EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Cytogenetic+analysis
has_MedDRA_id: 10011822

respiratory and pulmonary investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal respiratory and pulmonary investigation
definition editor: EB
has_MedDRA_id: 10038668

endocrine investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal result of an endocrine investigation
definition editor: EB
has_MedDRA_id: 10014706

adverse event causality evidence from randomized clinical trial
type: Class
subclass of: adverse event causality evidence from controlled clinical trial
definition: an adverse event causality evidence that comes from a randomized controlled clincal trial where a medical intervention is conducted in a random fashion
editor note: In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention.
definition editor: YH
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30.

blood parathyroid hormone level abnormal AE
type: Class
subclass of: endocrine investigation result abnormal AE
definition: an endocrine investigation result abnormal AE that is characterized by an abnormal blood parathyroid hormone level
definition editor: EB
has_MedDRA_id: 10005700

blood parathyroid hormone increased AE
type: Class
subclass of: blood parathyroid hormone level abnormal AE
definition: a blood parathyroid hormone level abnormal AE that is characterized by an increased blood parathyroid hormone level
definition editor: EB
has_MedDRA_id: 10005703

tri-iodothyronine level abnormal AE
type: Class
subclass of: endocrine investigation result abnormal AE
definition: an endocrine investigation result abnormal AE that is characterized by an abnormal tri-iodothyronine level
definition editor: EB
has_MedDRA_id: 10044592

tri-iodothyronine increased AE
type: Class
subclass of: tri-iodothyronine level abnormal AE
definition: a tri-iodothyronine level abnormal AE that is characterized by an increased tri-iodothyronine level
definition editor: EB
has_MedDRA_id: 10044596

protein and chemistry analysis result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that involves an abnormal protein and chemistry analysis result
definition editor: EB
has_MedDRA_id: 10037000

blood albumin level abnormal AE
type: Class
subclass of: protein and chemistry analysis result abnormal AE
definition: a protein and chemistry analysis result abnormal AE that is characterized by an abnormal blood albumin level
definition editor: EB
has_MedDRA_id: 10005286

blood albumin level increased AE
type: Class
subclass of: blood albumin level abnormal AE
definition: a blood albumin level abnormal AE that is characterized by an increased blood albumin level
definition editor: EB
has_MedDRA_id: 10005288

c-reactive protein level abnormal AE
type: Class
subclass of: protein and chemistry analysis result abnormal AE
definition: a protein and chemistry analysis result abnormal AE that is characterized by an abnormal c-reactive protein level
definition editor: EB
has_MedDRA_id: 10068559

c-reactive protein level decreased AE
type: Class
subclass of: c-reactive protein level abnormal AE
definition: a c-reactive protein level abnormal AE that is characterized by a decreased c-reactive protein level
definition editor: EB
has_MedDRA_id: 10049220

abdominal compartment syndrome AE
type: Class
subclass of: protein total abnormal AE
subclass of: compartment syndrome AE
definition: This is an AE which occurs when the abdomen becomes subject to increased pressure reaching past the point of intra-abdominal hypertension (IAH).
definition: a protein total abnormal AE that is characterized by an increased protein total
definition editor: EB
definition editor: QY, JX, HY
definition source: http://en.volupedia.org/wiki/Abdominal_compartment_syndrome
Chinese translation: 腹腔间室综合征
has_MedDRA_id: 10037016
has_MedDRA_id: 10058808
label: protein total increased AE

protein total decreased AE
type: Class
subclass of: protein total abnormal AE
definition: a protein total abnormal AE that is characterized by a decreased protein total
definition editor: EB
has_MedDRA_id: 10037014

MUGA scan result abnormal AE
type: Class
subclass of: cardiovascular investigation result abnormal AE
definition: a cardiac and vascular investigation result abnormal AE that involves an abnormal result from a test using a radioactive tracer (called a radionuclide) and a special camera to take pictures of your heart as it pumps blood
definition editor: EB
definition source: WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Radionuclide-Ventriculography-or-Radionuclide-Angiography-MUGA-Scan_UCM_446354_Article.jsp
has_MedDRA_id: 10028146

cardiac stress test result abnormal AE
type: Class
subclass of: cardiac function test abnormal AE
definition: a cardiac function test abnormal AE that shows an abnormal result on a cardiac stress test.
definition editor: EB, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Stress+Test
definition source: WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures
has_MedDRA_id: 10055014

enzyme investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that is characterized by an abnormal result of an enzyme investigation
definition editor: EB
has_MedDRA_id: 10014938

blood creatine phosphokinase level decreased AE
type: Class
subclass of: blood creatine phosphokinase level abnormal AE
definition: a blood creatine phosphokinase level abnormal AE that is characterized by a decreased blood creatine phosphokinase
definition editor: EB
has_MedDRA_id: 10067760

hematology investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002390
definition: an investigation result abnormal AE that is characterized by an abnormal result of a hematology investigation
definition editor: EB
alternative term: MedDRA: 10057755
alternative term: haematology investigation abnormal AE
has_MedDRA_id: 10018851

red blood cell profile abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that results in an abnormal red blood cell profile
definition editor: EB
has_MedDRA_id: 20000029

white blood cell profile abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that is characterized by an abnormal white blood cell profile
definition editor: EB
has_MedDRA_id: 20000030

neutrophil percentage abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal percentage of neutrophils
definition editor: EB
has_MedDRA_id: 10058134

neutrophil percentage decreased AE
type: Class
subclass of: neutrophil percentage abnormal AE
definition: a neutrophil percentage abnormal AE that is characterized by a decreased percentage of neutrophils
definition editor: EB
has_MedDRA_id: 10052223

basophil count abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal basophil count
definition editor: EB
has_MedDRA_id: 10060978

basophil count decreased AE
type: Class
subclass of: basophil count abnormal AE
definition: a basophil count abnormal AE that is characterized by a decreased basophil count
definition editor: EB
has_MedDRA_id: 10004167

eosinophil percentage abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil percentage
definition editor: EB
has_MedDRA_id: 10058133

eosinophil percentage decreased AE
type: Class
subclass of: eosinophil percentage abnormal AE
definition: an eosinophil percentage abnormal AE that is characterized by a decreased eosinophil percentage
definition editor: EB
has_MedDRA_id: 10052221

leukocyte cell number abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal leukocyte cell number
definition editor: EB

granulocyte count abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal granulocyte count
definition editor: EB
has_MedDRA_id: 10018678

granulocyte count increased AE
type: Class
subclass of: granulocyte count abnormal AE
definition: a granulocyte count abnormal AE that is characterized by an increased granulocyte count
definition editor: EB
has_MedDRA_id: 10018683

lymphocyte count abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte cell number
definition editor: EB
has_MedDRA_id: 10025252

lymphocyte percentage abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte percentage
definition editor: EB

monocyte percentage abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal monocyte percentage
definition editor: EB
has_MedDRA_id: 10067238

abdominal hernia AE
type: Class
subclass of: monocyte percentage abnormal AE
subclass of: OAE_0004352
definition: This is an AE which is the abnormal exit of tissue or an organ, such as the bowel, through the wall of the cavity in which it normally resides.
definition: a monoctyte percentage abnormal AE that is characterized by a decreased monocyte percentage
definition editor: EB
definition editor: QY, JX, HY
definition source: http://en.volupedia.org/wiki/Hernia#Individual_hernias
Chinese translation: 腹疝
has_MedDRA_id: 10052229
has_MedDRA_id: 10060954
label: monocyte percentage decreased AE

blood lactate dehydrogenase level abnormal AE
type: Class
subclass of: enzyme investigation result abnormal AE
definition: an enzyme investigation result abnormal AE that is characterized by an abnormal blood lactate dehydrogenase level
definition editor: EB
has_MedDRA_id: 10005627

blood lactate dehydrogenase level decreased AE
type: Class
subclass of: blood lactate dehydrogenase level abnormal AE
definition: a blood lactate dehydrogenase level abnormal AE that is characterized by a decreased blood lactate dehydrogenase
definition editor: EB
has_MedDRA_id: 10005629

troponin level abnormal AE
type: Class
subclass of: enzyme investigation result abnormal AE
definition: an enzyme investigation result abnormal AE that is characterized by an abnormal troponin level
definition editor: EB

muscle enzyme level abnormal AE
type: Class
subclass of: enzyme investigation result abnormal AE
definition: an enzyme investigation result abnormal AE that is characterized by an abnormal muscle enzyme level
definition editor: EB

muscle enzyme level decreased AE
type: Class
subclass of: muscle enzyme level abnormal AE
definition: a muscle enzyme level abnormal AE that is characterized by a decreased muscle enzyme level
definition editor: EB
has_MedDRA_id: 10057952

myoglobin blood abnormal AE
type: Class
subclass of: enzyme investigation result abnormal AE
definition: an enzyme investigation result abnormal AE that is characterized by an abnormal myoglobin level in the blood
definition editor: EB

myoglobin blood increased AE
type: Class
subclass of: myoglobin blood abnormal AE
definition: a myoglobin blood abnormal AE that is characterized by an increased myoglobin level in the blood
definition editor: EB
has_MedDRA_id: 10028625

myoglobin blood decreased AE
type: Class
subclass of: myoglobin blood abnormal AE
definition: a myoglobin blood abnormal AE that is characterized by a decreased myoglobin level in the blood
has_MedDRA_id: 10059940

gastrointestinal investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that is characterized by an abnormal result of a gastrointestinal investigation
definition editor: EB
has_MedDRA_id: 10017971

blood amylase level abnormal AE
type: Class
subclass of: gastrointestinal investigation result abnormal AE
definition: a gastrointestinal investigation result abnormal AE that is characterized by an abnormal blood amylase level
definition editor: EB
has_MedDRA_id: 10054822

blood amylase level decreased AE
type: Class
subclass of: blood amylase level abnormal AE
definition: a blood amylase level abnormal AE that is characterized by a decreased blood amylase level
definition editor: EB
has_MedDRA_id: 10005327

lipase level abnormal AE
type: Class
subclass of: gastrointestinal investigation result abnormal AE
definition: a gastrointestinal investigation result abnormal AE that is characterized by an abnormal lipase level
definition editor: EB
has_MedDRA_id: 10054821

lipase level increased AE
type: Class
subclass of: lipase level abnormal AE
definition: a lipase level abnormal AE that is characterized by an increased lipase level
definition editor: EB
has_MedDRA_id: 10024574

lipase level decreased AE
type: Class
subclass of: lipase level abnormal AE
definition: a lipase level abnormal AE that is characterized by a decreased lipase level
definition editor: EB
has_MedDRA_id: 10024573

liver related investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0002107
definition: an investigation result abnormal AE that is characterized by an abnormal liver related investigation result
definition editor: EB
has_MedDRA_id: 20000008

transaminase level abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a liver related investigation result abnormal AE that is characterized by an abnormal level of transaminases
definition editor: EB
has_MedDRA_id: 10062688

transaminase level decreased AE
type: Class
subclass of: transaminase level abnormal AE
definition: a transaminase level abnormal AE that is characterized by a decreased level of transaminases
definition editor: EB
has_MedDRA_id: 10054795

aspartate aminotransferase level abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: a liver related investigation result abnormal AE that is characterized by an abnormal aspartate aminotransferase level
definition editor: EB
has_MedDRA_id: 10003477

aspartate aminotransferase level decreased AE
type: Class
subclass of: aspartate aminotransferase level abnormal AE
definition: an aspartate aminotransferase level abnormal AE that is characterized by a decreased aspartate aminotransferase level
definition editor: EB
has_MedDRA_id: 10003479

gamma-glutamyltransferase level decreased AE
type: Class
subclass of: gamma-glutamyltransferase level abnormal AE
definition: a gamma-glutamyltransferase level abnormal AE that is characterized by a decreased gamma-glutamyltransferase level
definition editor: EB
has_MedDRA_id: 10017690

blood bilirubin level decreased AE
type: Class
subclass of: blood bilirubin level abnormal AE
definition: a blood bilirubin level abnormal AE that is characterized by a decreased blood bilirubin level
definition editor: EB
has_MedDRA_id: 10049869

imaging investigation result abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that is characterized by an abnormal result of an imaging investigation
definition editor: EB
has_MedDRA_id: 10022893

blood thromboplastin level abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that is characterized by an abnormal blood thromboplastin level
definition editor: EB
has_MedDRA_id: 10005824

blood thromboplastin level decreased AE
type: Class
subclass of: blood thromboplastin level abnormal AE
definition: a blood thromboplastin level abnormal AE that is characterized by a decreased blood thromboplastin level
definition editor: EB
has_MedDRA_id: 10005826

coagulation factor v level abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigations result abnormal AE that is characterized by an abnormal coagulation factor v level
definition editor: EB
has_MedDRA_id: 10061771

coagulation factor v level increased AE
type: Class
subclass of: coagulation factor v level abnormal AE
definition: a coagulation factor v level abnormal AE that is characterized by an increased coagulation factor v level
definition editor: EB
has_MedDRA_id: 10009756

prothrombin level abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin level
definition editor: EB
has_MedDRA_id: 10037048

prothrombin level increased AE
type: Class
subclass of: prothrombin level abnormal AE
definition: a prothrombin level abnormal AE that is characterized by an increased prothrombin level
definition editor: EB
has_MedDRA_id: 10037051
see also: HPO: HP_0003645
see also: SIDER: C0151872

prothrombin time abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin time
definition editor: EB
has_MedDRA_id: 10037057

prothrombin time shortened AE
type: Class
subclass of: prothrombin time abnormal AE
definition: a prothrombin time abnormal AE that is characterized by a shortened prothrombin time
definition editor: EB
has_MedDRA_id: 10037070

full blood count increased AE
type: Class
subclass of: full blood count abnormal AE
definition: a full blood count abnormal AE that is characterized by an increased full blood count
definition editor: EB
has_MedDRA_id: 10052239

red blood cell count abnormal AE
type: Class
subclass of: red blood cell profile abnormal AE
definition: a red blood cell profile abnormal AE that is characterized by an abnormal red blood cell count
definition editor: EB
has_MedDRA_id: 10038151

red blood cell count increased AE
type: Class
subclass of: red blood cell count abnormal AE
definition: a red blood cell count abnormal AE that is characterized by an increased red blood cell count
definition editor: EB
has_MedDRA_id: 10038155

hematocrit abnormal AE
type: Class
subclass of: red blood cell profile abnormal AE
definition: a red blood cell profile abnormal AE that is characterized by an abnormal hematocrit
definition editor: EB
has_MedDRA_id: 10057763

hematocrit increased AE
type: Class
subclass of: hematocrit abnormal AE
definition: a hematocrit abnormal AE that is characterized by an increased hematocrit
definition editor: EB
has_MedDRA_id: 10019424

hemoglobin level increased AE
type: Class
subclass of: hemoglobin level abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a hemoglobin level abnormal AE that is characterized by an increased hemoglobin level
definition editor: EB
has_MedDRA_id: 10055599
see also: CTCAE: E12171
see also: NCIt: C78333

mean corpuscular volume abnormal AE
type: Class
subclass of: red blood cell profile abnormal AE
definition: a red blood cell profile abnormal AE that is characterized by an abnormal mean corpuscular volume
definition editor: EB
has_MedDRA_id: 10027009

mean corpuscular volume increased AE
type: Class
subclass of: mean corpuscular volume abnormal AE
definition: a mean corpuscular volume abnormal AE that is characterized by an increased mean corpuscular volume
definition editor: EB
has_MedDRA_id: 10051859

mean corpuscular volume decreased AE
type: Class
subclass of: mean corpuscular volume abnormal AE
definition: a mean corpuscular volume abnormal AE that is characterized by a decreased mean corpuscular volume
definition editor: EB
has_MedDRA_id: 10051858

mean cell hemoglobin level abnormal AE
type: Class
subclass of: red blood cell profile abnormal AE
definition: a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin level
definition editor: EB

mean cell hemoglobin level increased AE
type: Class
subclass of: mean cell hemoglobin level abnormal AE
definition: a mean cell hemoglobin level abnormal AE that is characterized by an increased mean cell hemoglobin level
definition editor: EB
has_MedDRA_id: 10055622

mean cell hemoglobin level decreased AE
type: Class
subclass of: mean cell hemoglobin level abnormal AE
definition: a mean cell hemoglobin level abnormal AE that is characterized by a decreased mean cell hemoglobin level
definition editor: EB
has_MedDRA_id: 10055621

mean cell hemoglobin concentration abnormal AE
type: Class
subclass of: red blood cell profile abnormal AE
definition: a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin concentration
definition editor: EB
has_MedDRA_id: 10067730

mean cell hemoglobin concentration increased AE
type: Class
subclass of: mean cell hemoglobin concentration abnormal AE
definition: a mean cell hemoglobin concentration abnormal AE that is characterized by an increased mean cell hemoglobin concentration
definition editor: EB
has_MedDRA_id: 10026992

mean cell hemoglobin concentration decreased AE
type: Class
subclass of: mean cell hemoglobin concentration abnormal AE
definition: a mean cell hemoglobin concentration abnormal AE that is characterized by a decreased mean cell hemoglobin concentration
definition editor: EB
has_MedDRA_id: 10026991

sinoatrial node dysfunction AE
type: Class
subclass of: conduction system disorder AE
definition: a conduction system disorder that refers to abnormalities in SN impulse formation and propagation and includes sinus bradycardia, sinus pause/arrest, chronotropic incompetence, and sinoatrial exit block.
definition editor: SS
alternative term: SND
alternative term: sinus node dysfunction
definition source: WEB: http://emedicine.medscape.com/article/158064-overview

coronary disorder AE
type: Class
subclass of: coronary artery disorder AE
definition: a coronary artery disorder AE that takes place in or is related to the coronary inside the heart
editor note: Even though 'coronary disorder AE' seems to be a more general term of 'coronary artery disorder AE' that should place 'coronary disorder AE' as a parent of 'coronary artery disorder AE', KB's comment from clinical perspective is that these two terms are synonymous in practice, and coronary disorder almost always means coronary artery disorder. If 'coronary disorder AE' gets picked up from reports, it is a generalized term of 'coronary artery disorder AE'; and thereofore, we created a place holder for this term under 'coronary artery disorder AE'
definition editor: SS

inferior wall myocardial infarction AE
type: Class
subclass of: myocardial infarction AE
definition: a myocardial infarction AE in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery.
definition editor: SS
alternative term: myocardial infarction, inferior wall AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=inferior+wall+myocardial+infarction

anterior wall myocardial infarction AE
type: Class
subclass of: myocardial infarction AE
definition: a myocardial infarction AE in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction.
definition editor: SS
alternative term: myocardial infarction, anterior wall AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=anterior+wall+myocardial+infarction

blast cell count abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that is characterized by an abnormal blast cell count
definition editor: EB

blast cell count decreased AE
type: Class
subclass of: blast cell count abnormal AE
definition: a blast cell count abnormal AE that is characterized by a decreased blast cell count
definition editor: EB
has_MedDRA_id: 10062275

platelet count abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that is characterized by an abnormal platelet count
definition editor: EB
has_MedDRA_id: 10035526
see also: HPO: HP_0011873
see also: SIDER: C0580317

platelet count increased AE
type: Class
subclass of: platelet count abnormal AE
definition: a platelet count abnormal AE that is characterized by an increased platelet count
definition editor: SZ, SS, YH, EB
definition source: WEB: http://medical-dictionary.thefreedictionary.com/thrombocytosis
has_MedDRA_id: 10051608

eosinophil count abnormal AE
type: Class
subclass of: white blood cell profile abnormal AE
definition: a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil count
definition editor: EB
has_MedDRA_id: 10061125

eosinophil count decreased AE
type: Class
subclass of: eosinophil count abnormal AE
definition: an eosinophil count abnormal AE that is characterized by a decreased eosinophil count
definition editor: EB
has_MedDRA_id: 10014943

systemic hypertension AE
type: Class
subclass of: hypertension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: a hypertension AE that is characterized by high blood pressure in the systemic arteries - the vessels that carry blood from the heart to the body's tissues (other than the lungs).
definition editor: SS
definition source: WEB: http://www.pted.org/?id=syshypertension1

blood pressure systolic decreased AE
type: Class
subclass of: hypotension AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiomyopathy AE
definition: a hypotension AE that has an outcome of a decrease in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body
definition editor: SS
definition source: WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes
has_MedDRA_id: 10005758
see also: HPO: HP_0006673
see also: SIDER: C0277885

papillary muscle disorder AE
type: Class
subclass of: cardiac valve disease AE
definition: a cardiac valve disease AE that is characterized by an impaired function of a papillary muscle, usually due to ischemia or infarction, with resulting incompetence of the mitral (rarely tricuspid) valve.
definition editor: SS
alternative term: papillary muscle dysfunction
alternative term: papillary muscle syndrome
definition source: WEB: http://medical-dictionary.thefreedictionary.com/papillary+muscle+dysfunction
has_MedDRA_id: 10061330

blood pressure diastolic increased AE
type: Class
subclass of: hypertension AE
definition: a hypertension AE that has an outcome of an increase in the amount of pressure in the arteries when the heart is at rest between beats
definition editor: SS
definition source: WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers
has_MedDRA_id: 10005739
see also: HPO: HP_0005117
see also: SIDER: C0277889

blood pressure systolic increased AE
type: Class
subclass of: hypertension AE
definition: a hypertension AE that has an outcome of an increase in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body
definition editor: SS
definition source: WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers
has_MedDRA_id: 10005760
see also: HPO: HP_0004421
see also: SIDER: C0277884

right ventricular dysfunction AE
type: Class
subclass of: cardiac ventricular disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiac ventricular disorder AE that is a condition in nwhich the right ventricle of the heart was functionally impaired. This condition usually leads to heart failure or myocardial infarction, and other cardiovascular complicationns.
definition editor: SS
definition source: WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=right%20ventricular%20dysfunction
has_MedDRA_id: 10058597
see also: CTCAE: E10196
see also: NCIt: C50733

ventricular extrasystoles AE
type: Class
subclass of: extrasystoles AE
definition: an arrhythmia AE that is characterized by a premature contraction of the ventricle
definition editor: SS
alternative term: infranodal extrasystoles AE
definition source: WEB: http://dictionary.reference.com/browse/ventricular+extrasystole
has_MedDRA_id: 10047289
see also: HPO: HP_0006696
see also: SIDER: C0151636

cardiac embolism AE
type: Class
subclass of: embolism AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
definition: an embolism disorder AE that is a result of an obstruction in a cardiac vessel due to a blood clot or other foreign matters
definition editor: SS
alternative term: heart embolism AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Heart+embolism

embolism AE
type: Class
subclass of: vascular disorder AE
definition: a vascular disorder AE that is characterized by an obstruction in a blood vessel due to a blood clot or other foreign matter that gets stuck while traveling through the bloodstream.
definition editor: SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/embolism
Chinese translation: 栓塞
has_MedDRA_id: 10014523
see also: HPO: HP_0001907
see also: SIDER: C0013922

retrodictive AE causality
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition: an adverse event causity that represents a retrodictrive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: given an individual who has received a medical intervention and developed the adverse event, was the event caused by the medical intervention?
definition editor: YH
alternative term: retrodictive causality of adverse event
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20.

premature ventricular contractions AE
type: Class
subclass of: ventricular extrasystoles AE
definition: an arrhythmia AE that results in extra, abnormal heartbeats that begin in one of the heart's two lower pumping chambers (ventricles). These extra beats disrupt the regular heart rhythm, sometimes causing the patient to feel a flip-flop or skipped beat in the chest.
definition editor: SS
alternative term: PVCs
definition source: WEB: http://www.mayoclinic.com/health/premature-ventricular-contractions/DS00949
has_MedDRA_id: 10036614

pulmonary valve incompetence AE
type: Class
subclass of: cardiac valve disease AE
definition: a cardiac valve disease AE that is charaterized by the backflow of blood from the pulmonary artery into the right ventricle, owing to imperfect functioning of the pulmonary valve
definition editor: SS
alternative term: pulmonic incompetence AE
definition source: WEB: http://www.rightdiagnosis.com/medical/pulmonary_valve_incompetence.htm
has_MedDRA_id: 10037448
see also: HPO: HP_0010444
see also: SIDER: C0034088

pulmonary valve stenosis AE
type: Class
subclass of: cardiac valve disease AE
definition: a cardiac vavle disease AE that is characterized by a congenital heart defect in which blood flow from the heart to the pulmonary artery is blocked
definition editor: SS
alternative term: pulmonic stenosis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Pulmonary+Valve+Stenosis
has_MedDRA_id: 10037450

arteritis AE
type: Class
subclass of: vasculitis AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: a vasculitis AE that is an inflammation specific to an artery or arteries
definition editor: SS
definition source: WEB: http://medical-dictionary.thefreedictionary.com/arteritis
has_MedDRA_id: 10003230
see also: HPO: HP_0005291
see also: SIDER: C0003860

severity of adverse event
type: Class
subclass of: PATO_0001236
definition: a process quality that represents the level of severity of an adverse event.
definition editor: YH, SS
alternative term: AE severity

aneurysm AE
type: Class
subclass of: vascular disorder AE
definition: a vascular disorder AE that results in an abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel
definition editor: SS
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001122.htm
has_MedDRA_id: 10002329
see also: HPO: HP_0002617
see also: SIDER: C0002940

venous disorder AE
type: Class
subclass of: vascular disorder AE
definition: a vascular disorder that affects the veins or blood circulation of the veins
definition editor: SS

aneurysm ruptured AE
type: Class
subclass of: aneurysm AE
definition: an aneurysm AE that results in the weakening of the balloon-like bulge that the blood pressure causes the artery wall to leak or burst
definition editor: SS
alternative term: SAH
alternative term: ruptured aneurysm AE
alternative term: subarachnoid hemorrhage AE
definition source: WEB: http://www.mayfieldclinic.com/PE-AneurRupt.htm#.Uor4tI3QHh0
has_MedDRA_id: 10048380
see also: HPO: HP_0002617
see also: SIDER: C0162869

cardiac aneurysm AE
type: Class
subclass of: aneurysm AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
definition: an aneurysm AE that refers to an aneurysm involving cardiac tissue. This most often occurs as a ventricular aneurysm following a myocardial infarction
definition editor: SS
alternative term: aneurysm of heart AE
alternative term: heart aneurysm AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/19239694
has_MedDRA_id: 10007513

aortic aneurysm AE
type: Class
subclass of: aneurysm AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000947
definition: an aneurysm AE that occurs in the aorta
definition editor: SS
definition source: WEB: http://www.webmd.com/heart-disease/tc/aortic-aneurysm-overview
has_MedDRA_id: 10002882
see also: HPO: HP_0004942
see also: SIDER: C0003486

aortic aneurysm rupture AE
type: Class
subclass of: aneurysm ruptured AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000947
definition: an aneurysm ruptured AE that occurs in the aorta
definition editor: SS
alternative term: ruptured aortic aneurysm AE
has_MedDRA_id: 10002886
see also: HPO: HP_0002622
see also: SIDER: C0741160

aortic dissection AE
type: Class
subclass of: aortic disorder AE
definition: an aortic disorder AE in which there is a separation of the aorta walls. The small tear can become larger. It can lead to bleeding into and along the wall of the aorta, the major artery carrying blood out of the heart.
definition editor: SS
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000181.htm
has_MedDRA_id: 10002895
see also: HPO: HP_0004933
see also: SIDER: C0340643

ruptured cerebral aneurysm AE
type: Class
subclass of: aneurysm ruptured AE
definition: an aneurysm ruptured AE that occurs in the brain where blood spurts into the subarachnoid space under arterial pressure, continuing until increased local or generalized intracranial pressure stops the bleeding.
definition editor: SS
definition source: WEB: http://ether.stanford.edu/library/neuroanesthesia/Journal%20Articles/Ruptured%20cerebral%20aneurysms.pdf
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/15647574
has_MedDRA_id: 10039330

intracranial aneurysm AE
type: Class
subclass of: aneurysm AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
definition: an aneurysm AE that occurs in the brain
definition editor: SS
alternative term: brain aneurysm AE
alternative term: cerebral aneurysm AE
alternative term: intracerebral aneurysm AE
definition source: WEB: http://www.ninds.nih.gov/disorders/cerebral_aneurysm/detail_cerebral_aneurysms.htm
has_MedDRA_id: 10022758
see also: HPO: HP_0004944
see also: SIDER: C0007766

aortic thrombosis AE
type: Class
subclass of: OAE_0004574
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000947
definition: a thrombosis AE that is a rare lesion and may be defined as a thrombosis of a vessel without any obvious underlying cause that occurs in the aorta
definition editor: SS
definition source: WEB: http://circ.ahajournals.org/content/17/5/941.full.pdf
has_MedDRA_id: 10002910

carotid artery thrombosis AE
type: Class
subclass of: arterial thrombosis AE
definition: an arterial thrombosis AE that is characterized by the occurrence of a thrombus in the carotid arteries (two large blood vessels that supply oxygenated blood to the large, front part of the brain)
definition editor: SS
definition source: WEB: http://www.webmd.com/heart-disease/carotid-artery-disease-causes-symptoms-tests-and-treatment
has_MedDRA_id: 10007688

cerebral artery embolism AE
type: Class
subclass of: arterial embolism AE
definition: an arterial embolism AE that occurs in the cerebral artery
definition editor: SS
alternative term: cerebral embolism AE
alternative term: embolic stroke AE
alternative term: thrombotic stroke AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cerebral+embolism
has_MedDRA_id: 10008088
has_MedDRA_id: 10014498
has_MedDRA_id: 10043647

cerebral artery thrombosis AE
type: Class
subclass of: OAE_0004573
definition: an arterial thrombosis AE that occurs in the cerebral artery, also referred to as an embolism AE
editor note: [SS] Per DRA and KKB's comment, this term may also be characterized as a type of embolism even though labeled thrombosis.
alternative term: cerebral thrombosis AE
has_MedDRA_id: 10008092
has_MedDRA_id: 10008132

cerebral venous thrombosis AE
type: Class
subclass of: venous thrombosis AE
subclass of: OAE_0004573
definition: a venous thrombosis AE that is characterized by thrombosis of the venous channels in the brain. It is an uncommon cause of cerebral infarction relative to arterial disease, but it is an important consideration because of its potential morbidity.
editor note: [SS] From http://medical-dictionary.thefreedictionary.com/cerebral+venous+thrombosis, Merwarth syndrome - progressive hemiplegia due to venous occlusion. Synonym(s): cerebral venous thrombosis
definition editor: SS
definition source: WEB: http://emedicine.medscape.com/article/1162804-overview
has_MedDRA_id: 10008138

intracranial venous sinus thrombosis AE
type: Class
subclass of: venous thrombosis AE
subclass of: OAE_0004573
definition: a venous thrombosis AE that occurs when a blood clot forms in the brain’s venous sinuses that prevents blood from draining out of the brain. As a result, blood cells may break and leak blood into the brain tissues, forming a hemorrhage.
definition editor: SS
alternative term: CVST
definition source: WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/cerebral_venous_sinus_thrombosis_134,69/
has_MedDRA_id: 10061251

gas embolilsm AE
type: Class
subclass of: embolism AE
definition: an embolism AE that is caused by a gas bubble that enters the vein
editor note: [SS] The term 'gas embolism' is listed as a unique term, and not a superset or a synonym of 'air embolism' due to the different pathology reconized by physicians that air embolism is mostly recognized when an air bubble caused by IV or other injection device enters the vein, while a gas embolism is mostly caused by a gas bubble released as a product of an infection, or other devices such as nitrogen tank.
definition editor: SS

mesenteric vein thrombosis AE
type: Class
subclass of: venous thrombosis AE
subclass of: OAE_0004583
definition: a thrombosis that is characterized by a clot that blocks blood flow a mesenteric vein, one of two veins through which blood leaves the intestine. The condition interrupts the blood supply to the intestine and can result in damage to the intestines.
editor note: [SS] http://emedicine.medscape.com/article/193921-overview, Mesenteric venous thrombosis (also known as visceral venous thrombosis) is a rare but lethal form of mesenteric ischemia (see the image below). Antonio Hodgson first described mesenteric ischemia in the latter part of the 15th century. In 1895, Elliot first described mesenteric venous thrombosis as a cause of mesenteric ischemia. By the turn of the 19th century, many review articles and texts were describing the recent advances in the characterization and treatment of mesenteric ischemia, particularly venous thrombosis. In 1935, Warren and Eberhard reported that intestinal infarction resulted from ischemia due to venous thrombosis, and they reported a mortality rate of 34% in patients with venous thrombosis after resection. Unfortunately, despite improvements in therapy, this mortality rate still holds.
definition editor: SS
alternative term: mesenteric venous thrombosis AE
alternative term: visceral venous thrombosis AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001157.htm
has_MedDRA_id: 10027402

Budd-Chiari syndrome AE
type: Class
subclass of: thrombosis AE
definition: a thrombosis AE that is an uncommon condition induced by thrombotic or nonthrombotic obstruction of hepatic venous outflow and characterized by hepatomegaly, ascites, and abdominal pain.
definition editor: SS
definition source: WEB: http://emedicine.medscape.com/article/184430-overview
has_MedDRA_id: 10006537

retinal vein thrombosis AE
type: Class
subclass of: venous thrombosis AE
subclass of: OAE_0004545
definition: a thrombosis AE that occurs in the vein carrying the blood away from the retina
editor note: [SS] The term 'retinal vein thrombosis' is listed as a different class from 'retinal vein occlusion' for the difference in the pathological process of how the blockage occurs in the vein.
definition editor: SS
has_MedDRA_id: 10038908

predictive AE causality
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition: an adverse event causity that represents a predictive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: will the next person who received a medical intervention will develop the adverse event? Or: how frequently will vaccine recipients experience the adverse event as a result of a medical intervention?
definition editor: YH
alternative term: predictive causality of adverse event
definition source: Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20.

arterial embolism AE
type: Class
subclass of: embolism AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: an embolism AE that occurs in the artery. It is a sudden interruption of blood flow to an organ or body part due to a clot (embolus).
definition editor: SS
alternative term: embolism arterial AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001102.htm
has_MedDRA_id: 10014513

venous embolism AE
type: Class
subclass of: embolism AE
definition: a thrombosis AE* that is a result of when a blood vessel is obstructed by a blood clot (embolus) that has been carried in the bloodstream from the site of its formation. Thromboembolic disease includes both venous thromboembolism (VTE) and arterial thrombosis. VTE is an general term which refers to mainly two conditions: deep vein thrombosis (DVT) and its potentially fatal acute complication, pulmonary embolism (PE). Arterial embolism is a frequent complication in patients with atrial fibrillation (AF) and can lead to stroke or systemic embolism. * see editor note
editor note: [SS] Per DRA and KKB's comment, this term is synonymous to venous thrombosis even though labeled embolism. Cross-reference is made via seeAlso.
definition editor: SS
alternative term: VTE
alternative term: embolism venous AE
alternative term: venous thromboembolism AE
definition source: WEB: http://www.boehringer-ingelheim.com/products/prescription_medicines/thromboembolic_diseases.html
has_MedDRA_id: 10014522
see also: OAE: 0001505

fat embolism AE
type: Class
subclass of: embolism AE
definition: an embolism AE that is characterized by the obstruction of blood vessel by fat droplets
definition editor: SS
definition source: WEB: http://emedicine.medscape.com/article/460524-overview#showall
has_MedDRA_id: 10016246

septic embolus AE
type: Class
subclass of: embolism AE
definition: a embolism AE that is infected with bacteria containing pus
definition editor: SS
alternative term: septic embolism AE
definition source: WEB: http://www.medicalnewstoday.com/articles/153704.php
has_MedDRA_id: 10040067

thrombosis in device AE
type: Class
subclass of: thrombosis AE
definition: a thrombosis AE that occurs in or may be caused by an implanted device in the body
definition editor: SS
has_MedDRA_id: 10062546

obsolete: thrombotic microangiopathy AE
type: Class
subclass of: ObsoleteClass
definition: a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion
definition editor: SS
alternative term: TMA
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583
has_MedDRA_id: 10043645
comment: This term is obsolete since there is another term with the same name already. Oliver

arterial thrombosis limb AE
type: Class
subclass of: thrombosis AE
subclass of: arterial thrombosis AE
definition: an arterial thrombosis AE that occurs in the limb(s) of the body
definition editor: SS
has_MedDRA_id: 10003180

eye inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000970
definition: an inflammation AE that occurs in eye.
definition editor: YH, JX

injection site thrombosis AE
type: Class
subclass of: thrombosis AE
definition editor: SS
has_MedDRA_id: 10022104

pelvic venous thrombosis AE
type: Class
subclass of: deep vein thrombosis AE
definition: a deep vein thrombosis AE that occurs in the pelvis. Ovarian vein thrombosis arises out of the coincident conditions of venous stasis and hypercoagulability, which are commonly present in the recently postpartum patient.
definition editor: SS
alternative term: ovarian vein thrombosis AE
definition source: WEB: http://emedicine.medscape.com/article/404364-overview
has_MedDRA_id: 10034272

peripheral embolism AE
type: Class
subclass of: embolism AE
definition: an embolism AE that is charaterized by a sudden blockage in a lung artery. The blockage usually is caused by a blood clot that travels to the lung from a vein in the leg.
definition editor: SS
alternative term: PE
definition source: WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/pe/
has_MedDRA_id: 10061340

subclavian vein thrombosis AE
type: Class
subclass of: venous thrombosis AE
subclass of: OAE_0004582
definition: a thrombosis AE that occurs in subclavian vein. Among patients with effort-induced thrombosis with subclavian vein stenosis, the thrombosis occurs in the dominant arm in 80% of cases.
definition editor: SS
definition source: WEB: http://emedicine.medscape.com/article/424777-overview#showall
has_MedDRA_id: 10049446

superficial thrombophlebitis AE
type: Class
subclass of: thrombophlebitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a thrombophlebitis AE that is characterized by an inflammation of a vein due to a blood clot in a vein located just below the skin's surface.
editor note: YH: MedDRA: 10043595 is for "thrombophlebitis superficial"; MedDRA: 10042554 is for "superficial thrombophlebitis"
definition editor: SS, YH, MW
alternative term: thrombophlebitis superficial AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000199.htm
Chinese translation: 表在性血栓性静脈炎
see also: CTCAE: E13817
see also: NCIt: C78634
see also: UMLS CUI: C1510431

venous thrombosis limb AE
type: Class
subclass of: venous thrombosis AE
definition editor: SS
has_MedDRA_id: 10061408

retinal vein occlusion AE
type: Class
subclass of: vascular disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000966
definition: a thrombosis that is characterized by a blockage of the small veins that carry blood away from the retina. The retina is the layer of tissue at the back of the inner eye that converts light images to nerve signals and sends them to the brain.
definition editor: SS
alternative term: RVO
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007330.htm
has_MedDRA_id: 10038907

atrial thrombosis AE
type: Class
subclass of: OAE_0004574
definition: a thrombosis AE that occurs in the atrium (left or right)
definition editor: SS
definition source: WEB: http://ehjcimaging.oxfordjournals.org/content/9/1/204.full
has_MedDRA_id: 10048632

coronary artery thrombosis AE
type: Class
subclass of: arterial thrombosis AE
definition: an arterial thrombosis AE that occurs in the coronary artery
definition editor: SS
alternative term: coronary embolism AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Coronary+embolism
has_MedDRA_id: 10011084
has_MedDRA_id: 10011091

sleep apnea AE
type: Class
equivalent class: Class
  intersection of: apnea AE
  intersection of: sleep disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a sleep apnea AE is a sleep disorder AE in which breathing repeatedly stops and starts. Basically, it is a crossproduct of sleep disorder AE and apnea AE.
definition editor: MW, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/sleep-apnea/basics/definition/con-20020286
has_MedDRA_id: 10040975
see also: CTCAE: E13566
see also: NCIt: C26884

stroke AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a brain AE that occurs when flow of oxygen-rich blood to a portion of the brain is blocked
definition editor: JX, LW, YH
alternative term: cardiovascular accident AE
definition source: WEB: http://en.wikipedia.org/wiki/Stroke
definition source: WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/stroke/
Chinese translation: 中风
has_MedDRA_id: 10042244
see also: CTCAE: E12826
see also: NCIt: C3390

ischemic stroke AE
type: Class
subclass of: stroke AE
definition: a stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain.
definition editor: SS
alternative term: ischaemic stroke AE
definition source: WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
has_MedDRA_id: 10061256

hemorrhagic stroke AE
type: Class
subclass of: stroke AE
definition: a stroke AE that occurs when a blood vessel that supplies the brain ruptures and bleeds causing the deficiency of oxygen and nutrients to brain cells and tissues
definition editor: SS
alternative term: haemorrhagic stroke AE
definition source: WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
has_MedDRA_id: 10019016

intracerebral hemorrhagic stroke AE
type: Class
subclass of: hemorrhagic stroke AE
definition: a haemorrhagic stroke AE that is cuased by hypertension (high blood pressure), and bleeding occurs suddenly and rapidly.
definition editor: SS
alternative term: intracerebral haemorrhagic stroke AE
definition source: WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/

subarachnoid hemorrhagic stroke AE
type: Class
subclass of: hemorrhagic stroke AE
definition: a haemorrhagic stroke AE that is cuased by the bleeding (haemorrhage) between the brain and the meninges (the membrane that covers the brain) in the subarachnoid space.
definition editor: SS
alternative term: subarachnoid haemorrhagic stroke AE
definition source: WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/

thrombotic stroke AE
type: Class
subclass of: ischemic stroke AE
definition: an ischaemic stroke AE that is caused by a thrombus (blood clot) that develops in the arteries supplying blood to the brain
definition editor: SS
definition source: WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
has_MedDRA_id: 10043647

embolic stroke AE
type: Class
subclass of: ischemic stroke AE
definition: an ischaemic stroke AE that is caused by an embolus (a blood clot that formms elsewhere in the body and travels through the bloodstream to the brain).
definition editor: SS
definition source: WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
has_MedDRA_id: 10014498

psychiatric disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative.
definition editor: YH, Izabela Birsanescu
alternative term: mental disorder AE
definition source: WEB: http://en.wikipedia.org/wiki/Mental_disorder
has_MedDRA_id: 10037175

adjustment disorder AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that has an outcome of a adjustment disorder. An adjustment disorder is an unexpectedly strong emotional or behavioral reaction that occurs in response to an identifiable stressful life event or life change that occurred within the previous three months.
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://www.healthline.com/health/adjustment-disorder
has_MedDRA_id: 10001301
has_MedDRA_id: 10001302

adjustment disorder with depressed mood AE
type: Class
subclass of: adjustment disorder AE
definition: an adjustment disorder AE that has an additional depressed mood. The person is more depressed than would be expected after a stressful event.
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://www.summitmedicalgroup.com/library/adult_health/bha_adjustment_disorder_with_depressed_mood/
has_MedDRA_id: 10001297

anastomotic bleeding AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: a hemorrhage AE that has an outcome of bleeding from anastomosis site. Anastomosis: pathological formation of an opening between two normally distinct spaces or organs.
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://medical-dictionary.thefreedictionary.com/anastomosis
has_MedDRA_id: 10071781

Clostridium difficile infection AE
type: Class
subclass of: clostridial infection AE
definition: a clostridial infection AE that is caused by C. difficule.
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/c-difficile/basics/definition/CON-20029664?p=1
has_MedDRA_id: 10054236

Gram-negative bacteremia AE
type: Class
subclass of: bacteremia AE
definition editor: Yongqun He, Izabela Birsanescu
definition editor: a bacteraemia AE that is more specifically associated with a Gram-negative bacterium.
has_MedDRA_id: 10054228

drug level increase
type: Class
subclass of: PATO_0001018
definition: a physical quality that a drug level inside a host increases
definition editor: Yongqun He, Izabela Birsanescu

drug toxicity
type: Class
subclass of: quality
definition: a quality that represents the level of critical or lethal reaction to an erroneous dosage of a drug medication.
definition editor: Yognqun He, Izabela Birsanescu
definition source: WEB: http://medical-dictionary.thefreedictionary.com/drug+toxicity
comment: Drug toxicity may occur due to human error or intentional overdose in the case of suicide or homicide.

Intraoperative hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has an outcome of massive amounts of blood loss. A typical Intraoperative hemorrhage has a blood loss exceeding 1000 mL or requires a blood transfusion
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://www.uptodate.com/contents/management-of-hemorrhage-in-gynecologic-surgery
has_MedDRA_id: 10055298
see also: CTCAE: E11810
see also: NCIt: C35135

pancreatic abscess AE
type: Class
subclass of: abscess AE
definition: an abscess AE that shows a cavity of pus within the pancreas
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000270.htm
has_MedDRA_id: 10048984

pancreas transplant rejection AE
type: Class
subclass of: surgery adverse event
definition: a sugery AE that has an adverse outcome where the recipient’s body rejects the pancreas transplantation.
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://www.medscape.com/viewarticle/436542_13
has_MedDRA_id: 10049169

pyogenic infection AE
type: Class
subclass of: infection AE
definition: an infection AE that has an outcome of a severe local inflammation, usually with pus formation, generally caused by one of the pyogenic bacteria.
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=44396
has_MedDRA_id: 10021861

fever of unknown origin AE
type: Class
subclass of: fever AE
definition: a fever AE that has unknown origin.
definition editor: Yongqun He, Izabela Birsanescu
definition source: WEB: http://medicine.academic.ru/123590/fever_of_unknown_origin
has_MedDRA_id: 10016563

time interval for initial process after medical intervention
type: Class
subclass of: one-dimensional temporal region
definition: a temporal interval that starts at the time a medical intervention occurs and ends at the time when the initial bodily process occurs.
definition editor: Yongqun He

time interval for intermediate causal AE process
type: Class
subclass of: one-dimensional temporal region
definition: a temporal interval that starts at the time in the end of the initial process and ends at the time when the final process leading to an adverse event clinical outcome occurs.
definition editor: Yongqun He

time interval for AE process showing clinical outcome
type: Class
subclass of: one-dimensional temporal region
definition: a temporal interval that covers the time period of the final process leading to the display of clinical outcome.
definition editor: Yongqun He

initial stage causal AE sub-process
type: Class
subclass of: OGMS_0000061
definition: a pathological bodily process that starts to occur after a medical intervention.
definition editor: Yongqun He

intermediate stage causal AE sub-process
type: Class
subclass of: OGMS_0000061
definition: a pathological bodily process that occurs in the middle of the causal adverse event process, i.e., after the initial causal AE process and before the last AE process that results in the adverse outcome.
definition editor: Yongqun He

late stage AE formation sub-process
type: Class
subclass of: OGMS_0000061
definition: a pathological bodily process that occurs in the last stage of adverse event and results in the adverse clinical outcome. This clinical outcome may come as a result of causal adverse event (caused by the medical intervention), or result from an unrelevant cause (i.e., not the designated medical intervention).
definition editor: Yongqun He
alternative term: AE process showing pathological clinical outcome

adverse event time period
type: Class
subclass of: one-dimensional temporal region
definition: a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event ends. The adverse event ends when the patient recovers from the adverse event or dies due to the severity of the adverse event.
definition editor: Yongqun He

patient
type: Class
equivalent class: Class
  intersection of: OBI_0100026
  intersection of: Restriction
    on property: has role
    some values from: OBI_0000093
subclass of: OBI_0100026
definition: an organism that has the role of 'patient role'.
definition editor: Yongqun He

time interval for causal AE
type: Class
subclass of: adverse event time period
definition: an adverse event tme period whent the adverse event is causal adverse event.
definition editor: Yongqun He

causality based on Naranjo ADR probability scale
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition: a causality of AE based on the Naranjo ADR probability scale method.
editor note: SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
definition editor: Yongqun He
definition source: Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
definition source: WEB: http://livertox.nih.gov/Narajo.html

Definite Naranjo ADR probability
type: Class
subclass of: causality based on Naranjo ADR probability scale
definition: a Naranjo ADR probability scale that shows definite causality result. It happens when the score is >=9.
editor note: SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
definition editor: Yongqun He
definition source: Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
definition source: WEB: http://livertox.nih.gov/Narajo.html

Probably Naranjo ADR probability
type: Class
subclass of: causality based on Naranjo ADR probability scale
definition: a Naranjo ADR probability scale that shows probable causality result. It happens when the score is 5-8.
editor note: SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
definition editor: Yongqun He
definition source: Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
definition source: WEB: http://livertox.nih.gov/Narajo.html

Possible Naranjo ADR probability
type: Class
subclass of: causality based on Naranjo ADR probability scale
definition: a Naranjo ADR probability scale that shows possible causality result. It happens when the score is 1-4.
editor note: SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
definition editor: Yongqun He
definition source: Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
definition source: WEB: http://livertox.nih.gov/Narajo.html

Doubtful Naranjo ADR probability
type: Class
subclass of: causality based on Naranjo ADR probability scale
definition: a Naranjo ADR probability scale that shows doubtful causality result. It happens when the score is <=0.
editor note: SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
definition editor: Yongqun He
definition source: Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
definition source: WEB: http://livertox.nih.gov/Narajo.html

AE causality based on CDISC system
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition: a causality of AE that is based on the Clinical Data Interchange Consortium (CDISC) system
definition editor: Yongqun He
alternative term: causality based on the Clinical Data Interchange Consortium (CDISC) system
definition source: Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
definition source: WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf

Not Related AE causality based on CDISC system
type: Class
subclass of: AE causality based on CDISC system
definition: an AE causality based on CDISC system that has the scale "Not Related".
definition editor: Yongqun He
definition source: Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
definition source: WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf

Possibly Related AE causality based on CDISC system
type: Class
subclass of: AE causality based on CDISC system
definition: an AE causality based on CDISC system that has the scale "Possibly Related".
definition editor: Yongqun He
definition source: Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
definition source: WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf

Unlikely Related AE causality based on CDISC system
type: Class
subclass of: AE causality based on CDISC system
definition: an AE causality based on CDISC system that has the scale "Unlikely Related".
definition editor: Yongqun He
definition source: Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
definition source: WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf

Definitely Related AE causality based on CDISC system
type: Class
subclass of: AE causality based on CDISC system
definition: an AE causality based on CDISC system that has the scale "Definitely Related".
definition editor: Yongqun He
definition source: Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
definition source: WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf

Probably Related AE causality based on CDISC system
type: Class
subclass of: AE causality based on CDISC system
definition: an AE causality based on CDISC system that has the scale "Probably Related".
definition editor: Yongqun He
definition source: Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
definition source: WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf

causality based on DIPS score
type: Class
subclass of: a quality that represents the level of causality between a medical intervention and an adverse event outcome.
definition: an AE causality that is based on the Drug Interaction Probability Scale (DIPS).
editor note: Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2
definition editor: Yongqun He
definition source: Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.

Highly Probable causality based on DIPS score
type: Class
subclass of: causality based on DIPS score
definition: a causality based on DIPS score that is "Highly Probable". It occurs when the sore is >8.
editor note: Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2
definition editor: Yongqun He
definition source: Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.

Probable causality based on DIPS score
type: Class
subclass of: causality based on DIPS score
definition: a causality based on DIPS score that is "Probable". It occurs when the sore is 5-8.
editor note: Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2
definition editor: Yongqun He
definition source: Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.

Possible causality based on DIPS score
type: Class
subclass of: causality based on DIPS score
definition: a causality based on DIPS score that is "Possible". It occurs when the sore is 2-4.
editor note: Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2
definition editor: Yongqun He
definition source: Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.

Doubtful causality based on DIPS score
type: Class
subclass of: causality based on DIPS score
definition: a causality based on DIPS score that is "Doubtful". It occurs when the sore is <2.
editor note: Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2
definition editor: Yongqun He
definition source: Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.

AE severity G0
type: Class
subclass of: severity of adverse event
definition: a severity of AE that shows sign and symptom within normal limits.
definition editor: YH, SS
alternative term: AE severity Grade 0
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_0_Adverse_Event
comment: Note the AE severity Grade 0 equals to CTCAE G0 AE severity.
see also: CTCAE4: E10004 (Grade 0 Adverse Event)

AE severity G1
type: Class
subclass of: severity of adverse event
definition: a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated.
definition editor: YH, SS
alternative term: AE severity Grade 1
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event
comment: Note the AE severity Grade 1 equals to CTCAE G1 AE severity.
see also: CTCAE4: E10005 (Grade 1 Adverse Event)

AE severity G2
type: Class
subclass of: severity of adverse event
definition: a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).
definition editor: YH, SS
alternative term: AE severity Grade 2
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event
comment: Note the AE severity Grade 2 equals to CTCAE G2 AE severity.
see also: CTCAE4: E10006 (Grade 2 Adverse Event)

AE severity G3
type: Class
subclass of: severity of adverse event
definition: a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet).
definition editor: YH, SS
alternative term: AE severity Grade 3
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event
comment: Note the AE severity Grade 3 equals to CTCAE G3 AE severity.
see also: CTCAE4: E10007 (Grade 3 Adverse Event)

AE severity G4
type: Class
subclass of: severity of adverse event
definition: a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral).
definition editor: YH, SS
alternative term: AE severity Grade 4
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event
comment: Note the AE severity Grade 4 equals to CTCAE G4 AE severity.
see also: CTCAE4: E10008 (Grade 4 Adverse Event)

AE severity G5
type: Class
subclass of: severity of adverse event
definition: a severity of AE that results in death.
definition editor: YH, SS
alternative term: AE severity Grade 5
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event
comment: Note the AE severity Grade 5 equals to CTCAE G5 AE severity.
see also: CTCAE4: E10009 (Grade 5 Adverse Event)

hyperphosphatemia AE
type: Class
subclass of: blood phosphate abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood phosphorus increased
definition: a blood phosphate abnormal AE that has an abnormally increased amount of phosphate in the blood
definition editor: EB, YH, MW
definition source: WEB: https://en.wikipedia.org/wiki/Hyperphosphatemia
has_MedDRA_id: 10020712
see also: HPO: HP_0002905

X-ray clinical test
type: Class
subclass of: clinical laboratory test
definition: a clincal laboratory test that performs a medical examination using X-ray, a type of electromagnetic radiation.
definition editor: Rebecca Racz, Yongqun He
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003337.htm

cardio-respiratory distress AE
type: Class
subclass of: respiratory distress AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac failure AE
definition: a respiratory distress AE that is characterized by insufficient oxygen flow in the heart and respiratory system.
definition editor: SS, YH
definition source: WEB: http://medicalcenter.osu.edu/patientcare/healthcare_services/lung_diseases/about/signs/Pages/index.aspx, http://www.merriam-webster.com/dictionary/cardiorespiratory
has_MedDRA_id: 10049874

joint effusion AE
type: Class
subclass of: joint disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: A joint disorder AE that has the presence of increased intra-articular fluid. It can be caused by trauma, arthritis, or gout and often affects the knee.
definition editor: RR, YH, MW
definition source: PMID: 19915432
definition source: WEB: http://en.wikipedia.org/wiki/Joint_effusion
has_MedDRA_id: 10023215

gastric disorder AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0000945
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000945
definition: a gastrointestinal disorder AE that shows a problem with the stomach, ranging from indigestion and heartburn to peptic ulcers and GERD.
definition editor: RR, YH
alternative term: stomach disorder AE
definition source: WEB: http://www.nlm.nih.gov/medlineplus/stomachdisorders.html
has_MedDRA_id: 10056819

fluid replacement
type: Class
subclass of: medical intervention
definition: A medical intervention that involves the replacement of bodily fluids excessively lost. Fluids may be replaced orally or intravenously.
definition editor: RR, YH
alternative term: fluid resuscitation
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/dehydration/basics/treatment/con-20030056
has_MedDRA_id: 10061858

thyroiditis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002046
definition: An inflammation AE that displays an inflammation (not an infection) of the thyroid gland.
definition source: http://www.endocrineweb.com/conditions/thyroid/thyroiditis
creator: yongqun he, liwei wang

glucosuria AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001088
definition: a urinary system AE that has an outcome of the excretion of glucose into the urine.
definition source: web: http://en.wikipedia.org/wiki/glycosuria
comment: LW, YH

granuloma AE
type: Class
subclass of: inflammation AE
definition: an inflammation AE that shows localized nodular inflammation found in tissues.
definition editor: KM, JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Granuloma
definition source: WEB: http://www.mayoclinic.org/granuloma/expert-answers/faq-20057838
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3629
has_MedDRA_id: 10018691

skin burning sensation AE
type: Class
subclass of: burning sensation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002097
definition: a burning sensation AE that occurs at the skin.
definition editor: KM, JX, YH
has_MedDRA_id: 10054786

numbness AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of numbness, a loss of sensation of feeling in a part of the body.
definition editor: YH, JS
definition source: WEB: http://www.mayoclinic.org/symptoms/numbness/basics/definition/sym-20050938
has_MedDRA_id: 10029829

interstitial pneumonia AE
type: Class
subclass of: pneumonia AE
definition: a pneumonia AE that occurs at the interstitial lung. Interstitial pneumonia is often caused by an infection of bacteria, viruses, or fungii. A bacterium called Mycoplasma pneumonia is the most common cause.
definition editor: JX, YH
definition source: WEB: http://www.webmd.com/lung/interstitial-lung-disease
has_MedDRA_id: 10022617

circumoral numbness AE
type: Class
subclass of: numbness AE
definition: a numbness AE that occurs around the mouth.
editor note: The terms 'circumoral numbness AE' and 'circumoral paresthesia AE' appear to be synonyms.
definition editor: YH, JS
definition source: WEB: http://link.springer.com/referenceworkentry/10.1007%2F3-540-29623-9_6515
has_MedDRA_id: 10049339

skin necrosis AE
type: Class
subclass of: necrosis AE
definition: Skin necrosis AE is a necrosis AE that results in the death of the skin tissue. Skin necrosis often occurs when not enough blood and oxygen are supplied to a given skin region.
definition editor: JX, LW, YH
Chinese translation: 皮肤坏死
has_MedDRA_id: 10040893
see also: UMLS ID: C0151799

systemic lupus erythematosus AE
type: Class
subclass of: lupus AE
definition: Systemic lupus erythematosus (SLE) syndrome AE is a lupus syndrome AE that is systemic and disseminated. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. Although “lupus” actually includes a number of different diseases, SLE is the most common type of lupus, and when people say “lupus,” they are often referring to SLE.
definition editor: JX, LW, YH
alternative term: SLE
alternative term: systemic lupus erythematosus syndrome AE
alternative term: 系统性红斑狼疮
definition source: WEB: http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus
definition source: WEB: http://www.healthline.com/health/systemic-lupus-erythematosus#Overview1
Chinese translation: 系统性红斑狼疮综合征

urgent urination AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: Urgent urination AE is a urinary system AE that has an outcome of a sudden, compelling urge to urinate, along with discomfort in the bladder.
definition editor: JX, LW, YH
alternative term: micturition urgency
alternative term: urinary urgency
definition source: WEB: http://sideeffects.embl.de/se/C0085606/
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003140.htm
Chinese translation: 尿急
has_MedDRA_id: 10046593
see also: CTCAE: E13062
see also: NCIt: C50792
see also: UMLS CUI: C0439609

precordialgia AE
type: Class
subclass of: pain AE
definition: Precordialgia AE is a pain AE that pain located in the precordial region.
definition editor: JX, LW, YH
definition source: WEB: http://www.drugs.com/dict/precordialgia.html
Chinese translation: 心前痛

dyshidrosis AE
type: Class
subclass of: skin AE
definition: Dyshidrosis AE is a skin AE that shows a disorder of eccrine sweat glands, characterized by small blisters on the hands or feet.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Dyshidrosis
Chinese translation: 汗疱疹
has_MedDRA_id: 10013912

ankle swelling AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001474
definition: Ankle swelling AE is an edema AE that shows abnormal buildup of fluid in the ankles. Ankle swelling is a sign of fluid buildup or inflammation of the joint and tissues of the ankle. Mild ankle swelling is a common occurrence after standing for a long period.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthgrades.com/symptoms/ankle-swelling
Chinese translation: 踝部水肿
has_MedDRA_id: 10002554
see also: UMLS ID: C0235439

renal dysfunction AE
type: Class
subclass of: kidney AE
definition: Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia.
editor note: This term appears to be a synonym to the 'renal failure AE'.
definition editor: JX, LW, YH
alternative term: hepatic and renal function disorder AE
Chinese translation: 肾功能障碍
see also: UMLS ID: C0859242

epiphora AE
type: Class
subclass of: eye AE
definition: Epiphora AE is a eye AE that shows an overflow of tears onto the face. In this case, there is insufficient tear film drainage from the eyes, and the tears will drain down the face rather than through the nasolacrimal system.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Epiphora_(medicine)
Chinese translation: 泪溢
has_MedDRA_id: 10015068
see also: UMLS ID: C0152227

hemolytic anemia AE
type: Class
subclass of: anemia AE
definition: Hemolytic anemia AE is an anemia AE associated with hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). Such an AE can be relatively harmless or life-threatening.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hemolytic_anemia
Chinese translation: 溶血性贫血
has_MedDRA_id: 10019493

somniloquy AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavioral and neurological AE where somniloquy also is called sleep-talking, a parasomnia that refers to talking aloud while asleep. Somniloquy can be quite loud, ranging from simple mumbling sounds to loud shouts and long frequently inarticulate speeches, and can occur many times during a sleep cycle. As with sleepwalking and night terrors, sleeptalking usually occurs during the less-deep delta-wave NREM sleep stages or during temporary arousals therefrom.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Somniloquy
Chinese translation: 梦呓

cholelithiasis AE
type: Class
subclass of: hepatobiliary or pancreatic AE
definition: Cholelithiasis AE is a liver, biliary, and pancreatic AE that shows hard deposits forming inside the gallbladder. Gallstones may be as small as a grain of sand or as large as a golf ball.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Gallstone
has_MedDRA_id: 10008629
see also: UMLS ID: C1328486

blepharoptosis AE
type: Class
subclass of: eye AE
definition: Blepharoptosis AE is an eye AE that shows droopy upper eyelid or ptosis that presents with substantial blockage upper part of field of vision, risk of amblyopia among young children, and dramatic change in the facial appearance.
definition editor: JX, LW, YH
definition source: WEB: http://eyewiki.aao.org/Blepharoptosis
Chinese translation: 眼睑下垂
has_MedDRA_id: 10005157

AE associated dose range
type: Class
subclass of: quality
definition: A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to, at which point AE symptoms begin to arise. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses.
definition editor: AG, YH
definition source: OBI

adverse event recovery
type: Class
subclass of: process
definition editor: A healing process that leads to an outcome with improved relative health from an adverse event
definition editor: AG, YH
alternative term: AE recovery

AE recovery rate
type: Class
subclass of: extent of AE recovery
definition: an AE recovery rate that represents a rate of adverse event recovery
definition editor: AG, YH

chemotherapy drug AE recovery
type: Class
subclass of: adverse event recovery
definition: An AE recovery that is sepcifically for recovery from a chemotherapy drug adverse event.
definition editor: AG, YH

complete AE recovery
type: Class
subclass of: extent of AE recovery
definition editor: AG, YH

extent of AE recovery
type: Class
subclass of: information content entity
definition: an information content entity that represents an extent of recovery from an adverse event
definition editor: AG, YH

incomplete AE recovery
type: Class
subclass of: extent of AE recovery
definition: an extent of AE recovery that has an outcome of incomplete recovery
definition editor: AG, YH

grand mal AE
type: Class
subclass of: epileptic seizure AE
definition: an epileptic seizure AE that is characterized by tonic-clonic seizures, involving two phases -- the tonic phase in which the body becomes rigid, and clonic phase in which there is uncontrolled jerking.
definition editor: JX, LW, YH
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32957
Chinese translation: 癫痫大发作
has_MedDRA_id: 10018658

erythema simplex AE
type: Class
subclass of: erythema AE
definition: Erythema simplex AE is an erythema AE that accompany with blushing or redness of the skin caused by a toxic reaction or a neurovascular phenomenon.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/erythema+simplex
Chinese translation: 单纯性红斑

pelvic pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0010709
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Pelvic pain AE is a pain AE that occurs in the lower abdomen area. The pain might be steady, or it might come and go. If the pain is severe, it might get in the way of people's daily activities.
definition editor: JX, LW, YH, MW
definition source: WEB: http://www.nlm.nih.gov/medlineplus/pelvicpain.html
Chinese translation: 骨盆痛
has_MedDRA_id: 10034263

extrasystoles AE
type: Class
subclass of: arrhythmia AE
definition: Extrasystoles AE is an arrhythmia AE that shows a premature contraction of the heart that is independent of the normal rhythm of the heart and arises in response to an impulse in some part of the heart other than the normal impulse from the sinoatrial node. The extrasystole is followed by a pause, as the heart electrical system "resets" itself and the contraction following the pause is usually more forceful than normal.
definition editor: JX, LW, YH
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32159
Chinese translation: 早搏（额外收缩）
has_MedDRA_id: 10015856

increased upper airway secretion AE
type: Class
subclass of: respiratory system AE
definition: An increased upper airway secretion AE is a respiratory system AE characterized by an increased secretion at the upper airway location.
definition editor: RR, YH
has_MedDRA_id: 10062717

feeling of body temperature change AE
type: Class
subclass of: feeling abnormal AE
definition: Feeling of body temperature change AE is a feeling abnormal AE that a patient feels a change in body temperature.
definition editor: RR, YH
has_MedDRA_id: 10061458

heartburn AE
type: Class
subclass of: gastric disorder AE
definition: Heartburn AE is a gastric disorder AE that also known as pyrosis, cardialgia, or acid indigestion. It's a burning sensation in the chest, just behind the breastbone or in the epigastrium, the upper central abdomen. The pain often rises in the chest and may radiate to the neck, throat, or angle of the jaw.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Heartburn
Chinese translation: 胃灼热（烧心）
has_MedDRA_id: 10019326

tonsillitis AE
type: Class
subclass of: inflammation AE
definition: Tonsillitis AE is an inflammation AE that is inflammation of the tonsils most commonly caused by viral or bacterial infection. Symptoms may include sore throat and fever.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Tonsillitis
Chinese translation: 扁桃体炎
has_MedDRA_id: 10044008

non-insulin-dependent diabetes mellitus AE
type: Class
subclass of: diabetes mellitus AE
definition: Non-insulin-dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 2, it's characterized by hyperglycemia (high blood sugar) in the context of insulin resistance and relative lack of insulin.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2
Chinese translation: 非胰岛素依赖型糖尿病
has_MedDRA_id: 10029505

insulin dependent diabetes mellitus AE
type: Class
subclass of: diabetes mellitus AE
definition: Insulin dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 1. It results from the autoimmune destruction of the insulin-producing beta cells in the pancreas.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1
Chinese translation: 胰岛素依赖型糖尿病
has_MedDRA_id: 10022497

areflexia AE
type: Class
subclass of: OAE_0003236
definition: a hyporeflexia AE where the patient shows no sign of reflexes.
definition editor: JX, LW, YH
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423
Chinese translation: 反射消失
has_MedDRA_id: 10003084

mastauxe AE
type: Class
subclass of: reproductive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000310
definition: Mastauxea AE is a reproductive system AE that shows enlargement of the breast.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/mastauxe
Chinese translation: 乳房增大

uveitis AE
type: Class
subclass of: eye inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: Uveitis AE is an inflammation AE that is inflammation of the uvea, which lines the inside of the eye behind the cornea.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Uveitis
Chinese translation: 色素层炎
has_MedDRA_id: 10046851
see also: CTCAE: E10442
see also: NCIt: C26909

sexual dysfunctions AE
type: Class
subclass of: reproductive system AE
definition: Sexual dysfunctions AE is a reproductive system AE that is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.
definition editor: JX, LW, YH
alternative term: sexual malfunction AE
definition source: WEB: http://en.wikipedia.org/wiki/Sexual_dysfunction
Chinese translation: 性功能障碍
has_MedDRA_id: 10040477

hypomnesia AE
type: Class
subclass of: behavioral and neurological AE
definition: Hypomnesia AE is a behavior and neurological AE that is an archaic term applied to poor memory, the impaired ability to recall information previously memorized.
definition editor: JX, LW, YH
definition source: WEB: http://psychology.wikia.com/wiki/Hypomnesia
Chinese translation: 记忆减退
has_MedDRA_id: 10021035

phobia AE
type: Class
subclass of: behavioral and neurological AE
definition: Phobia AE is a behavior and neurological AE that is a type of anxiety disorder, usually defined as a persistent fear of an object or situation in which the sufferer commits to great lengths in avoiding, typically disproportional to the actual danger posed, often being recognized as irrational.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Phobia
Chinese translation: 恐惧症
has_MedDRA_id: 10034912

lymphadenectasis AE
type: Class
subclass of: edema AE
definition: Lymphadenectasis AE is an edema AE that shows enlargement of the lymph node.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/lymphadenectasis
Chinese translation: 淋巴结肿大
has_MedDRA_id: 10025282

asterixis AE
type: Class
subclass of: tremor AE
definition: Asterixis AE is a tremor AE that also called the flapping tremor, or liver flap, which is a tremor of the hand when the wrist is extended, sometimes said to resemble a bird flapping its wings. This motor disorder is characterized by an inability to actively maintain a position, which is demonstrated by jerking movements of the outstretched hands when bent upward at the wrist. The tremor is caused by abnormal function of the diencephalic motor centers in the brain, which regulate the muscles involved in maintaining position.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Asterixis
Chinese translation: 扑翼样震颤
has_MedDRA_id: 10003547

parageusia AE
type: Class
subclass of: gustatory system AE
definition: Parageusia AE is a gustatory system AE which is the medical term for a bad taste in the mouth. One common form of parageusia is a metallic taste of food. This can be a side effect of several medications, such as acetazolamide, eszopiclone, zopiclone, metronidazole, or etoposide. Metallic taste is also a type of dysgeusia which is frequently associated with infections in the mouth or upper airways.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Parageusia
Chinese translation: 味觉颠倒
has_MedDRA_id: 10033793

brain damage AE
type: Class
subclass of: brain AE
definition: Brain damage AE is a brain AE that also called brain injury is the destruction or degeneration of brain cells. In general, brain damage refers to significant, undiscriminating trauma-induced damage.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Brain_damage
Chinese translation: 脑损伤
has_MedDRA_id: 10056389

frequent bowel movements AE
type: Class
subclass of: abnormal stool AE
definition: Frequent bowel movements AE is a abnormal stool AE that people are having more bowel movements than is normal for them. Often, frequent bowel movements are accompanied by diarrhea, the passage of loosely formed stool.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthgrades.com/symptoms/frequent-bowel-movements
Chinese translation: 大便频繁
has_MedDRA_id: 10017367

hyperprolactinemia AE
type: Class
subclass of: endocrine investigation result abnormal AE
definition: Hyperprolactinemia AE is an endocrine investigation result abnormal AE that is the presence of abnormally high levels of prolactin in the blood. Normal levels are less than 500 mIU/L [20 ng/mL or µg/L] for women, and less than 450 mIU/L for men.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hyperprolactinaemia
Chinese translation: 高泌乳素血症
has_MedDRA_id: 10020739

galactorrhea AE
type: Class
subclass of: reproductive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000310
definition: Galactorrhea AE is a reproductive system AE that is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Galactorrhea
Chinese translation: 乳溢
has_MedDRA_id: 10017592

sitophobia AE
type: Class
subclass of: behavioral and neurological AE
definition: Sitophobia AE is a behavior and neurological AE that shows a morbid or insane dread of eating.
definition editor: JX, LW, YH
definition source: WEB: http://en.wiktionary.org/wiki/sitophobia
Chinese translation: 畏食

ejection murmur AE
type: Class
subclass of: cardiac disorder AE
definition: Ejection murmur AE is a cardiac disorder AE which is due to turbulent forward flow across the right and left ventricular outflow tract, aortic or pulmonary valve, or through the aorta or pulmonary artery.
definition editor: JX, LW, YH
definition source: WEB: http://www.cardiologysite.com/auscultation/html/ejection_murmurs.html
Chinese translation: 收缩期喷射性杂音

hypoactive sexual desire disorder AE
type: Class
subclass of: libido disorder AE
definition: Hypoactive sexual desire disorder AE is a libido disorder AE that is considered a sexual dysfunction and is characterized as a lack or absence of sexual fantasies and desire for sexual activity, as judged by a clinician.
definition editor: JX, LW, YH
alternative term: hyposexuality AE
definition source: WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder
Chinese translation: 性欲减退
has_MedDRA_id: 10020933

bigotry AE
type: Class
subclass of: behavioral and neurological AE
definition: Bigotry AE is a behavior and neurological AE that is a state of mind where a person strongly and unfairly dislikes other people, ideas, etc.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Bigotry
Chinese translation: 偏执

somnambulism AE
type: Class
subclass of: behavioral and neurological AE
definition: Somnambulisma AE is a behavior and neurological AE that also known as sleepwalking or noctambulism, which is a sleep disorder belonging to the parasomnia family. It arise from the slow wave sleep stage in a state of low consciousness and perform activities that are usually performed during a state of full consciousness. These activities can be as benign as sitting up in bed, walking to the bathroom, and cleaning, or as hazardous as cooking, driving, violent gestures, grabbing at hallucinated objects, or even homicide.
definition editor: JX, LW, YH
alternative term: noctambulism AE
alternative term: sleepwalking AE
definition source: WEB: http://en.wikipedia.org/wiki/Sleepwalking
Chinese translation: 梦游症
has_MedDRA_id: 10041347

hyperphagia AE
type: Class
subclass of: eating disorder AE
definition: Hyperphagia AE is an eating disorder AE that also called polyphagia. It's a medical sign meaning excessive hunger and abnormally large intake of solids by mouth. It can be caused by disorders such as diabetes, Kleine–Levin syndrome (a malfunction in the hypothalamus), the genetic disorders Prader–Willi syndrome, and Bardet–Biedl syndrome.
definition editor: JX, LW, YH
alternative term: polyphagia AE
alternative term: 食欲过盛
definition source: WEB: http://en.wikipedia.org/wiki/Polyphagia
has_MedDRA_id: 10020710

corneal pigmentation AE
type: Class
subclass of: eye AE
definition: Corneal pigmentation is a eye AE shows that the melanin is in the superficial stroma and the basal layer of the corneal epithelium.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/corneal+pigmentation
Chinese translation: 角膜色素沉着
has_MedDRA_id: 10011040

chromatosis AE
type: Class
subclass of: skin AE
definition: Chromatos AE is a skin AE shows that deposit of pigment in a normally unpigmented area or excessive pigmentation in a normally pigmented site.
definition editor: JX, LW, YH
definition source: WEB: http://www.merriam-webster.com/medical/chromatosis
Chinese translation: 色素沉着

subclavian steal syndrome AE
type: Class
subclass of: ischemia AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000160
definition: Subclavian steal syndrome AE is an ischaemia AE that is a constellation of signs and symptoms that arise from retrograde (reversed) flow of blood in the vertebral artery or the internal thoracic artery, due to a proximal stenosis (narrowing) and/or occlusion of the subclavian artery. The arm may be supplied by blood flowing in a retrograde direction down the vertebral artery at the expense of the vertebrobasilar circulation. This is called the subclavian steal.
definition editor: JX, LW, YH
alternative term: subclavian steal phenomenon AE
alternative term: subclavian steal steno-occlusive disease AE
Chinese translation: 锁骨下动脉盗血综合征
has_MedDRA_id: 10042335

allergic rhinitis AE
type: Class
subclass of: rhinitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: Allergic rhinitis AE is a rhinitis AE that is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system.
definition editor: JX, LW, YH, MW
definition source: WEB: http://en.wikipedia.org/wiki/Allergic_rhinitis
Chinese translation: 过敏性鼻炎
has_MedDRA_id: 10001723

ventricular ectopic beats AE
type: Class
subclass of: cardiac ventricular disorder AE
definition: Ventricular ectopic beats AE is a cardiac ventricular disorder AE that is a disturbance of the cardiac rhythm frequently related to the electrical conduction system of the heart, in which beats arise from fiber or group of fibers outside the region in the heart muscle ordinarily responsible for impulse formation.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Ectopic_beat
Chinese translation: 心室异位搏动
has_MedDRA_id: 10058291

sjogren syndrome AE
type: Class
subclass of: eye AE
definition: Sjogren syndrome AE is a eye AE that is a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands, that produce saliva and tears, respectively.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Sj%C3%B6gren's_syndrome
Chinese translation: 干燥综合症
has_MedDRA_id: 10040767

nocturia AE
type: Class
subclass of: urine abnormality AE
definition: Nocturia AE is a urine abnormality AE that is defined by the International Continence Society as “the complaint that the individual has to wake at night one or more times for voiding”.
definition editor: JX, LW, YH
alternative term: nycturia AE
definition source: WEB: http://en.wikipedia.org/wiki/Nocturia
Chinese translation: 夜尿症
has_MedDRA_id: 10029446

night sweat AE
type: Class
subclass of: sweating AE
definition: Night sweat is a sweating AE that is the occurrence of excessive sweating (hyperhidrosis and focal hyperhidrosis) during sleep. The sufferer may or may not also suffer from excessive perspiration while awake.
definition editor: JX, LW, YH
alternative term: sleep hyperhidrosis AE
definition source: WEB: http://en.wikipedia.org/wiki/Night_sweats
Chinese translation: 夜汗
has_MedDRA_id: 10029409

increased appetite AE
type: Class
subclass of: gustatory system AE
definition: Increased appetite AE is a gustatory system AE that is when people want to eat much more often or in larger quantities than their body requires.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthline.com/symptom/increased-appetite
Chinese translation: 食欲增加
has_MedDRA_id: 10021654

vascular dilatation headache AE
type: Class
subclass of: headache AE
definition: Vascular dilatation headache AE is a headache AE that shows headache which caused by vascular dilatation.
definition editor: JX, LW, YH
definition source: WEB: http://www.headaches.org/education/Headache_Topic_Sheets/Vascular_Headaches
Chinese translation: 血管扩张性头痛

bundle-branch block AE
type: Class
subclass of: conduction system disorder AE
definition: Bundle-branch block AE is a conduction system disorder AE that refers to a defect of the heart's electrical conduction system.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Bundle_branch_block
Chinese translation: 束支传导阻滞
has_MedDRA_id: 10006578

unstable diabetes AE
type: Class
subclass of: diabetes mellitus AE
definition: Unstable diabetes AE is a diabetes mellitus AE that is a type of diabetes when a person's blood glucose level often swings quickly from high to low and from low to high.
definition editor: JX, LW, YH
alternative term: brittle diabetes AE
alternative term: labile diabetes AE
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=7271
Chinese translation: 不稳定型糖尿病
has_MedDRA_id: 10006372

tendon rupture AE
type: Class
subclass of: tendon disorder AE
definition: Tendon rupture AE is a tendon disorder AE shows a tearing of the tendon that occurs when the forces placed upon the tendon exceed its tensile strength.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Tendon+rupture
Chinese translation: 肌腱断裂
has_MedDRA_id: 10043248

tendovaginitis AE
type: Class
subclass of: inflammation AE
definition: Tendovaginitis AE is an inflammation AE that is an acute or chronic inflammation of the tendon sheath, occurring in the region of the hand, the wrist joint, the forearm (radial and ulnar tenobursitis), the foot, the ankle joint, and the Achilles tendon (achillobursitis).
definition editor: JX, LW, YH
alternative term: tenovaginitis AE
definition source: WEB: http://encyclopedia2.thefreedictionary.com/Tendovaginitis
Chinese translation: 腱鞘炎
has_MedDRA_id: 10067216

loose stools AE
type: Class
subclass of: abnormal stool AE
definition: Loose stools AE is a abnormal stool AE that is usually a form of diarrhea and many conditions causing loose stool will be listed under diarrhea. It may also be related to watery stool (also within the spectrum of diarrhea).
definition editor: JX, LW, YH
definition source: WEB: http://www.rightdiagnosis.com/sym/loose_stool.htm
Chinese translation: 稀便
has_MedDRA_id: 10024840

cystitis AE
type: Class
subclass of: inflammation AE
definition: Cystitis AE is an inflammation AE that is the medical term for inflammation of the bladder. Most of the time, the inflammation is caused by a bacterial infection, and it's called a urinary tract infection.
definition editor: JX, LW, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/cystitis/basics/definition/con-20024076
Chinese translation: 膀胱炎
has_MedDRA_id: 10011781

eructation AE
type: Class
subclass of: digestive system AE
definition: Eructation AE is a digestive system AE that is the release of gas from the digestive tract (mainly esophagus and stomach) through the mouth. It is usually accompanied with a typical sound and, at times, an odor.
definition editor: JX, LW, YH
alternative term: belching AE
alternative term: burping AE
alternative term: ructus AE
definition source: WEB: http://en.wikipedia.org/wiki/Burping
Chinese translation: 嗳气
has_MedDRA_id: 10015137

glossolalia AE
type: Class
subclass of: speech disorder AE
definition: Glossolalia AE is a speech disorder AE that is the fluid vocalizing of speech-like syllables that lack any readily comprehended meaning.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Glossolalia
Chinese translation: 语言不清

leg pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000978
definition: Leg pain AE is a pain AE that is a common problem in leg, it can be due to a cramp, injury, or other cause.
definition editor: JX, LW, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003182.htm
Chinese translation: 腿痛
has_MedDRA_id: 10024130

stomach ache AE
type: Class
subclass of: abdominal pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000945
definition: Stomachache AE is a pain AE that the pain in or near your stomach. It is a common symptom associated with transient disorders or serious disease.
definition editor: JX, LW, YH
alternative term: abdominal pain AE
alternative term: stomach pain AE
alternative term: stomachache AE
definition source: WEB: http://en.wikipedia.org/wiki/Abdominal_pain http://www.nhs.uk/conditions/stomach-ache-abdominal-pain/Pages/Introduction.aspx
Chinese translation: 胃痛
has_MedDRA_id: 10042126
see also: CTCAE: E10460
see also: NCIt: C26682

conduction block AE
type: Class
subclass of: conduction system disorder AE
definition: Conduction block AE is a conduction system disorder AE that shows failure of impulse transmission at some point along a nerve fiber, although conduction along the segments proximal and distal to it are unaffected.
definition editor: JX, LW, YH
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=10757
Chinese translation: 传导阻滞

photodermatitis AE
type: Class
subclass of: dermatitis AE
definition: Photodermatitis AE is a dermatitis AE that referred to as sun poisoning or photoallergy, is a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Photodermatitis
Chinese translation: 光敏性皮炎

pygalgia AE
type: Class
subclass of: pain AE
definition: Pygalgia AE is a pain AE that is a rarely used term meaning pain in the buttocks.
definition editor: JX, LW, YH
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=74312
Chinese translation: 臀痛

throat irritation AE
type: Class
subclass of: discomfort AE
definition: Throat irritation AE is a discomfort AE that refers to a dry cough, a scratchy feeling at the back of the throat, or a sensation of a lumpy feeling or something stuck at the back of the throat.
definition editor: JX, LW, YH
alternative term: throat discomfort AE
definition source: WEB: http://en.wikipedia.org/wiki/Throat_irritation
Chinese translation: 咽喉不适
has_MedDRA_id: 10043521

interstitial nephritis AE
type: Class
subclass of: inflammation AE
definition: Interstitial nephritis AE is an inflammation AE that is a form of nephritis affecting the interstitium of the kidneys surrounding the tubules. This disease can be either acute, meaning it occurs suddenly, or chronic, meaning it is ongoing and eventually ends in kidney failure.
definition editor: JX, LW, YH
alternative term: tubulointerstitial nephritis AE
definition source: WEB: http://en.wikipedia.org/wiki/Interstitial_nephritis
Chinese translation: 间质肾炎
has_MedDRA_id: 10048302

hoarseness AE
type: Class
subclass of: voice alteration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Hoarseness AE is a hoarseness AE that refers to a difficulty making sounds when trying to speak. Vocal sounds may be weak, breathy, scratchy, or husky, and the pitch or quality of the voice may change.
definition editor: JX, LW, YH, MW
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003054.htm
Chinese translation: 声音嘶哑
has_MedDRA_id: 10020201

photosensitization AE
type: Class
subclass of: hypersensitivity AE
definition: Photosensitization AE is a hypersensitivity AE that refers to development of abnormally heightened reactivity of the skin or eyes to sunlight.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/photosensitization
Chinese translation: 光敏

fanconi syndrome AE
type: Class
subclass of: kidney AE
definition: Fanconi syndrome AE is a kidney AE that is a disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine, instead of being reabsorbed.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Fanconi_syndrome
Chinese translation: 范可尼综合征
has_MedDRA_id: 10016219

keratoconjunctivitis AE
type: Class
subclass of: inflammation AE
definition: Keratoconjunctivitis AE is an inflammation AE that is inflammation of the cornea and conjunctiva. When only the cornea is inflamed, it is called keratitis; when only the conjunctiva is inflamed, it is called conjunctivitis.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Keratoconjunctivitis
Chinese translation: 角膜结膜炎
has_MedDRA_id: 10023348

hepatic insufficiency AE
type: Class
subclass of: liver AE
definition: Hepatic insufficiency AE is a liver disorder AE that shows a failure or partial failure of normal liver function.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hepatic+insufficiency
Chinese translation: 肝功能不全
has_MedDRA_id: 10056542

hypoxemia AE
type: Class
subclass of: blood gas investigation result abnormal AE
definition: Hypoxemia AE is a blood gas investigation result abnormal AE that is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hypoxemia
Chinese translation: 低血氧症
has_MedDRA_id: 10021142

irritant contact dermatitis AE
type: Class
subclass of: dermatitis AE
definition: Irritant contact dermatitis AE is a dermatitis AE that is a form of contact dermatitis that can be divided into forms caused by chemical irritants and those caused by physical irritants.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Irritant_contact_dermatitis
Chinese translation: 刺激性接触性皮炎

pitting edema AE
type: Class
subclass of: edema AE
definition: Pitting edema AE is an edema AE that shows observable swelling of body tissues due to fluid accumulation that may be demonstrated by applying pressure to the swollen area (such as by depressing the skin with a finger).
definition editor: JX, LW, YH
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=88528
Chinese translation: 指压性水肿
has_MedDRA_id: 10054547

acute bronchitis AE
type: Class
subclass of: bronchitis AE
definition: Acute bronchitis AE is a bronchitis AE that is an inflammation of the large bronchi (medium-size airways) in the lungs that is usually caused by viruses or bacteria and may last several days or weeks. Characteristic symptoms include cough, sputum (phlegm) production, and shortness of breath and wheezing related to the obstruction of the inflamed airways.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Acute_bronchitis
Chinese translation: 急性支气管炎
has_MedDRA_id: 10000687

renal calculus AE
type: Class
subclass of: kidney AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Renal calculus AE is a kidney AE that is a solid concretion or crystal aggregation formed in the kidneys from minerals in the urine. Kidney stones typically leave the body by passage in the urine stream, and many stones are formed and passed without causing symptoms. If stones grow to sufficient size (usually at least 3 millimeters (0.12 in)) they can cause blockage of the ureter. This leads to pain, most commonly beginning in the flank or lower back and often radiating to the groin or genitals.
definition editor: JX, LW, YH
alternative term: CTCAE: E13018
alternative term: NCIt: C26807
alternative term: kidney stone AE
alternative term: nephrolithiasis AE
alternative term: renal calculi AE
definition source: WEB: http://en.wikipedia.org/wiki/Kidney_stone
Chinese translation: 肾结石
has_MedDRA_id: 10038385
has_MedDRA_id: 10038386

clouding of consciousness AE
type: Class
subclass of: sensory capability AE
definition: Clouding of consciousness AE is a sensory capability AE that is a term used in conventional medicine denoting an abnormality in the "regulation" of the "overall level" of consciousness that is mild and less severe than a delirium. The sufferer experiences a subjective sensation of mental clouding described as feeling "foggy".
definition editor: JX, LW, YH
alternative term: brain fog AE
alternative term: mental fog AE
definition source: WEB: http://en.wikipedia.org/wiki/Clouding_of_consciousness
Chinese translation: 意识模糊

reflex tachycardia AE
type: Class
subclass of: tachycardia AE
definition: Reflex tachycardia AE is a tachycardia AE that shows increased heart rate in response to some stimulus conveyed through the cardiac nerves.
definition editor: JX, LW, YH
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=89526
Chinese translation: 反射性心动过速
has_MedDRA_id: 10063096

joint sprain AE
type: Class
subclass of: joint disorder AE
definition: Joint sprain AE is a joint disorder AE that is damage to one or more ligaments in a joint, often caused by trauma or the joint being taken beyond its functional range of motion.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Sprain
Chinese translation: 关节扭伤
has_MedDRA_id: 10023229

epicondylitis AE
type: Class
subclass of: inflammation AE
definition: Epicondylitis AE is an inflammation AE that is a type of musculoskeletal disorder that refers to an inflammation of an epicondyle.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Epicondylitis
Chinese translation: 上髁炎
has_MedDRA_id: 10014971

melanoglosia AE
type: Class
subclass of: tongue disorder
definition: Melanoglosia AE is a tongue AE that shows tongue turn black. Any blackening of the tongue associated with certain disorders and diseases in animals and humans.
definition editor: JX, LW, YH
definition source: WEB: http://encyclopedia2.thefreedictionary.com/melanoglosia
Chinese translation: 舌黑
has_MedDRA_id: 10014971

ventricular tachycardia AE
type: Class
subclass of: tachycardia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Ventricular tachycardia AE is a tachycardia AE that is a type of tachycardia, or a rapid heart beat that arises from improper electrical activity of the heart presenting as a rapid heart rhythm, that starts in the bottom chambers of the heart, called the ventricles.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Ventricular_tachycardia
Chinese translation: 心室性心搏过速
has_MedDRA_id: 10047302
see also: CTCAE: E10239
see also: NCIt: C50802

granulomatous hepatitis AE
type: Class
subclass of: hepatitis AE
definition: Granulomatous hepatitis AE is a hepatitis AE that refers to an inflammatory liver disease associated with granuloma formation in the liver.
definition editor: JX, LW, YH
definition source: WEB: http://radiopaedia.org/articles/granulomatous-hepatitis
Chinese translation: 肉芽肿性肝炎

hypogeusia AE
type: Class
subclass of: gustatory system AE
definition: Hypogeusia AE is a gustatory system AE that is a reduced ability to taste things (to taste sweet, sour, bitter, or salty substances).
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hypogeusia
Chinese translation: 味觉减弱
has_MedDRA_id: 10020989

dysphoria AE
type: Class
subclass of: behavioral and neurological AE
definition: Dysphoria AE is a behavior and neurological AE that is a profound state of unease or dissatisfaction. In a psychiatric context, dysphoria may accompany depression, anxiety, or agitation. Common reactions to dysphoria include emotional distress or indifference.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Dysphoria
Chinese translation: 烦躁不安
has_MedDRA_id: 10013954

oneirism AE
type: Class
subclass of: behavioral and neurological AE
definition: Oneirism AE is a behavior and neurological AE that is a state of abnormal consciousness in which dream-like experiences and hallucinations happen while awake.
definition editor: JX, LW, YH
definition source: WEB: http://en.wiktionary.org/wiki/oneirism
Chinese translation: 梦幻症
has_MedDRA_id: 10030332

podalgia AE
type: Class
subclass of: pain AE
definition: Podalgia AE is a pain AE that shows pain in the foot.
definition editor: JX, LW, YH
definition source: WEB: http://en.wiktionary.org/wiki/podalgia
Chinese translation: 足痛

brachialgia AE
type: Class
subclass of: pain AE
definition: Brachialgia AE is a pain AE that shows pain in the arm.
definition editor: JX, LW, YH
definition source: WEB: http://en.wiktionary.org/wiki/brachialgia
Chinese translation: 臂痛
has_MedDRA_id: 10068901

coxalgia AE
type: Class
subclass of: pain AE
definition: Coxalgia AE is a pain AE that shows pain in the hip.
definition editor: JX, LW, YH
definition source: WEB: http://en.wiktionary.org/wiki/coxalgia
Chinese translation: 髋痛
has_MedDRA_id: 10011249

limb injury AE
type: Class
subclass of: injury AE
definition: Limb injury AE is an injury AE which involve damage to bones, joints, ligament, musles, the major blood vessels and nerves of the limb.
definition editor: JX, LW, YH
Chinese translation: 肢体伤
has_MedDRA_id: 10061225

polymyalgia rheumatica AE
type: Class
subclass of: myalgia AE
definition: Polymyalgia rheumatica AE is a muscle pain AE that is a syndrome with pain or stiffness, usually in the neck, shoulders, and hips. The pain can be very sudden, or can occur gradually over a period. It may be caused by an inflammatory condition of blood vessels such as temporal arteritis.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Polymyalgia_rheumatica
Chinese translation: 风湿性多发性肌痛
has_MedDRA_id: 10036099

fibromyalgia AE
type: Class
subclass of: myalgia AE
definition: Fibromyalgia AE is a muscle pain AE that is characterised by chronic widespread pain and allodynia (a heightened and painful response to pressure). Fibromyalgia symptoms are not restricted to pain, leading to the use of the alternative term fibromyalgia syndrome for the condition. Other symptoms include debilitating fatigue, sleep disturbance, and joint stiffness.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Fibromyalgia
Chinese translation: 纤维肌痛
has_MedDRA_id: 10048439

hepatic encephalopathy AE
type: Class
subclass of: encephalopathy AE
definition: Hepatic encephalopathy AE is an encephalopathy AE that is the occurrence of confusion, altered level of consciousness, and coma as a result of liver failure. In the advanced stages it is called hepatic coma or coma hepaticum.
definition editor: JX, LW, YH
alternative term: portosystemic encephalopathy AE
definition source: WEB: http://en.wikipedia.org/wiki/Hepatic_encephalopathy
has_MedDRA_id: 10019660

chorea AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE AE that is an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias.
definition editor: JX, LW, YH
alternative term: choreia AE
definition source: WEB: http://en.wikipedia.org/wiki/Chorea
Chinese translation: 舞蹈症
has_MedDRA_id: 10008748

nightmare AE
type: Class
subclass of: sleep disorder AE
definition: Nightmare AE is a sleep disorder AE that is an unpleasant dream that can cause a strong emotional response from the mind, typically fear or horror but also despair, anxiety and great sadness.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Nightmare
Chinese translation: 梦魇
has_MedDRA_id: 10029412

depersonalization AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that is an anomaly of self-awareness. It consists of a feeling of watching oneself act, while having no control over a situation. Subjects feel they have changed, and the world has become vague, dreamlike, less real, or lacking in significance. It can be a disturbing experience, since many feel that, indeed, they are living in a "dream".
definition editor: JX, LW, YH
alternative term: depersonalisation AE
definition source: WEB: http://en.wikipedia.org/wiki/Depersonalization
Chinese translation: 人格解体
has_MedDRA_id: 10012359

apatheia AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that refers to a state of mind where one is not disturbed by the passions.
definition editor: JX, LW, YH
alternative term: apathia AE
definition source: WEB: http://en.wikipedia.org/wiki/Apatheia
Chinese translation: 情感冷漠

parosmia AE
type: Class
subclass of: sensory capability AE
definition: Parosmia AE is a sensory capability AE that is an olfactory dysfunction which is characterized by the inability of the brain to properly identify an odor’s “natural” smell.
definition editor: JX, LW, YH
alternative term: cacosmia AE
alternative term: troposmia AE
alternative term: 味觉倒错
definition source: WEB: http://en.wikipedia.org/wiki/Parosmia
has_MedDRA_id: 10034018

xerophthalmia AE
type: Class
subclass of: eye AE
definition: Xerophthalmia AE is an eye AE that is a medical condition in which the eye fails to produce tears.
definition editor: JX, LW, YH
alternative term: xerophthalmus AE
definition source: WEB: http://en.wikipedia.org/wiki/Xerophthalmia
Chinese translation: 干眼病
has_MedDRA_id: 10048221

chondropathy AE
type: Class
subclass of: bone AE
definition: Chondropathy AE is a bone disorder AE that refers to a disease of the cartilage. It is frequently divided into 5 grades, with 0-2 defined as normal, and 3-4 defined as diseased.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Chondropathy
Chinese translation: 软骨病
has_MedDRA_id: 10061762

teratogenesis AE
type: Class
subclass of: female reproductive system AE
definition: Teratogenesis AE is a female reproductive system AE that is a prenatal toxicity characterized by structural or functional defects in the developing embryo or fetus. It also includes intrauterine growth retardation, death of the embryo or fetus, and transplacental carcinogenesis.
definition editor: JX, LW, YH
definition source: WEB: http://www.britannica.com/EBchecked/topic/587782/teratogenesis
Chinese translation: 畸胎

premature atrial contraction AE
type: Class
subclass of: arrhythmia AE
definition: Premature atrial contraction AE is an arrhythmia AE that is a common cardiac dysrhythmia characterized by premature heartbeats originating in the atria.
definition editor: JX, LW, YH
alternative term: atrial premature beats AE
alternative term: atrial premature complexes AE
definition source: WEB: http://en.wikipedia.org/wiki/Premature_atrial_contraction
Chinese translation: 早搏
has_MedDRA_id: 10056964

parotitis AE
type: Class
subclass of: inflammation AE
definition: An inflammation AE that courrs in one or both parotid glands, the major salivary glands located on either side of the face, in humans. The parotid gland is the salivary gland most commonly affected by inflammation.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Parotitis
Chinese translation: 腮腺炎
has_MedDRA_id: 10034038

glossitis AE
type: Class
subclass of: inflammation AE
definition: Glossitis AE is an inflammation AE that can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal surface of the tongue, leaving a smooth and erythematous surface.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Glossitis
Chinese translation: 舌炎
has_MedDRA_id: 10018386

genital edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Genital edema AE is an edema AE that can be the result of interruption to the lymphatic drainage of this area caused by tumor, surgical removal of lymph nodes, radiotherapy or infection. Congenital disorders causing inadequate lymphatics can sometimes lead to the development of this condition.
definition editor: JX, LW, YH, MW
definition source: WEB: http://www.lymphoedemanz.org.nz/About+Lymphoedema/Genital+Oedema.html
Chinese translation: 生殖器水肿
has_MedDRA_id: 10018146

orgasm incapacity AE
type: Class
subclass of: reproductive system AE
definition: Orgasm incapacity AE is a reproductive system AE that the disorder characterized by an inability to achieve orgasm.
definition editor: JX, LW, YH
Chinese translation: 缺乏性高潮

sedation AE
type: Class
subclass of: behavioral and neurological AE
definition: Sedation AE is a behavior and neurological AE that is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Sedation
Chinese translation: 镇静
has_MedDRA_id: 10039897

sinus bradycardia AE
type: Class
subclass of: bradycardia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Sinus bradycardia AE is a bradycardia AE that is a heart rhythm that originates from the sinus node and has a rate that is lower than normal. In humans, bradycardia is generally defined to be a rate of under 60 beats per minute.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Sinus_bradycardia
Chinese translation: 窦性心动过缓
has_MedDRA_id: 10040741
see also: CTCAE: E10208
see also: NCIt: C26923

cardiac output decreased AE
type: Class
subclass of: cardiac disorder AE
definition: Cardiac output decreased AE is a cardiac disorder AE that shows a state in which the blood pumped by an individual's heart is sufficiently reduced that it is inadequate to meet the needs of the body's tissues. Cardiac output is the volume of blood being pumped by the heart, in particular by a left or right ventricle in the time interval of one minute.
definition editor: JX, LW, YH
definition source: WEB: http://www1.us.elsevierhealth.com/MERLIN/Gulanick/archive/Constructor/gulanick10.html http://en.wikipedia.org/wiki/Cardiac_output
Chinese translation: 心输出量减少
has_MedDRA_id: 10007595

steatorrhea AE
type: Class
subclass of: digestive system AE
definition: Steatorrhea AE is a digestive system AE that is the presence of excess fat in feces. Stools may also float due to excess lipid, have an oily appearance and can be especially foul-smelling.
definition editor: JX, LW, YH
alternative term: steatorrhoea AE
definition source: WEB: http://en.wikipedia.org/wiki/Steatorrhea
Chinese translation: 脂溢
has_MedDRA_id: 10041968

malabsorption syndrome AE
type: Class
subclass of: digestive system AE
definition: Malabsorption syndrome AE is a digestive system AE that refers to a number of disorders in which the intestine’s ability to absorb certain nutrients, such as vitamin B12 and iron, into the bloodstream is negatively affected.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthline.com/health/malabsorption#Overview1
Chinese translation: 吸收不良综合症
has_MedDRA_id: 10025479

sialadenitis AE
type: Class
subclass of: inflammation AE
definition: Sialadenitis AE is an inflammation AE that is inflammation of a salivary gland. It may be subdivided temporally into acute, chronic and recurrent forms.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Sialadenitis
Chinese translation: 唾液腺炎
has_MedDRA_id: 10040627

parkinson's disease AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that shows a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain, the cause of this cell death is unknown.
definition editor: JX, LW, YH
alternative term: choreia AE
alternative term: hypokinetic rigid syndrome AE
alternative term: idiopathic/primary parkinsonism AE
alternative term: paralysis agitans AE
definition source: WEB: http://en.wikipedia.org/wiki/Parkinson's_disease
Chinese translation: 帕金森综合症
has_MedDRA_id: 10061536

urinary calculus AE
type: Class
subclass of: urinary system AE
definition: Urinary calculus AE a urinary system AE that is solid particles in the urinary system. They may cause pain, nausea, vomiting, hematuria, and, possibly, chills and fever due to secondary infection.
definition editor: JX, LW, YH
alternative term: urinary calculi AE
definition source: WEB: http://www.merckmanuals.com/professional/genitourinary_disorders/urinary_calculi/urinary_calculi.html
Chinese translation: 尿结石
has_MedDRA_id: 10046531

sinoatrial block AE
type: Class
subclass of: conduction system disorder AE
definition: Sinoatrial block AE is a conduction system disorder AE that shows the electrical impulse is delayed or blocked on the way to the atria, thus delaying atrial depolarization.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Sinoatrial_block
Chinese translation: 窦房阻滞
has_MedDRA_id: 10040736

hyperthyroidism AE
type: Class
subclass of: endocrine system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Hyperthyroidism AE is an endocrine system AE that is a condition in which the thyroid gland produces and secretes excessive amounts of the free (not protein bound circulating in the blood) thyroid hormones -triiodothyronine (T3) and/or thyroxine (T4).
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hyperthyroidism
Chinese translation: 甲状腺机能亢进
has_MedDRA_id: 10020850
see also: CTCAE: E10322
see also: NCIt: C3123

akathisia AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Akathisia AE is a behavior and neurological AE that is a movement disorder characterized by a feeling of inner restlessness and a compelling need to be in constant motion, as well as by actions such as rocking while standing or sitting, lifting the feet as if marching on the spot, and crossing and uncrossing the legs while sitting. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace.
definition editor: JX, LW, YH, MW
alternative term: acathisia AE
definition source: WEB: http://en.wikipedia.org/wiki/Akathisia
Chinese translation: 静坐困难
has_MedDRA_id: 10001540

retinopathy AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: Retinopathy AE is an eye AE that is due to persistent or acute damage to the retina of the eye. Ongoing inflammation and vascular remodeling may occur over periods of time where the patient is not fully aware of the extent of the disease. Frequently, retinopathy is an ocular manifestation of systemic disease as seen in diabetes or hypertension.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Retinopathy
Chinese translation: 视网膜病变
has_MedDRA_id: 10038923
see also: CTCAE: E10432
see also: NCIt: C62601

sinus arrest AE
type: Class
subclass of: arrhythmia AE
definition: Sinus arrest AE is an arrhythmia AE that is a medical condition wherein the sinoatrial node of the heart transiently ceases to generate the electrical impulses that normally stimulate the myocardial tissues to contract and thus the heart to beat. It is defined as lasting from 2.0 seconds to several minutes.
definition editor: JX, LW, YH
alternative term: sinoatrial arrest AE
alternative term: sinus pause AE
definition source: WEB: http://en.wikipedia.org/wiki/Sinoatrial_arrest
Chinese translation: 窦性停搏
has_MedDRA_id: 10040738

ST segment depression AE
type: Class
subclass of: electrocardiogram result abnormal AE
definition: ST segment depression AE is an electrocardiogram result abnormal AE that refers to a finding on an electrocardiogram. It may be determined by measuring the vertical distance between the patient's trace and the isoelectric line at a location 2-3 millimeters from the QRS complex. It is significant if it is more than 1 mm in V5-V6, or 1.5 mm in AVF or III.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/ST_depression
Chinese translation: ST段下降
has_MedDRA_id: 10041892

T-wave inversion AE
type: Class
subclass of: electrocardiogram result abnormal AE
definition: T-wave inversion AE is an electrocardiogram result abnormal AE that can be a sign of coronary ischemia, Wellens' syndrome, left ventricular hypertrophy, or CNS disorder. In electrocardiography, the T wave represents the repolarization (or recovery) of the ventricles.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/T_wave
Chinese translation: T波倒置
has_MedDRA_id: 10042966

hyperthermia AE
type: Class
subclass of: abnormal body temperature AE
definition: Hyperthermia AE is an abnormal body temperature AE that is elevated body temperature due to failed thermoregulation that occurs when a body produces or absorbs more heat than it dissipates. Extreme temperature elevation then becomes a medical emergency requiring immediate treatment to prevent disability or death.
definition editor: JX, LW, YH, SJ
definition source: WEB: http://en.wikipedia.org/wiki/Hyperthermia
Chinese translation: 体温过高
has_MedDRA_id: 10020843

priapism AE
type: Class
subclass of: male reproductive system AE
definition: Priapism AE a male reproductive system AE that is a potentially painful medical condition in which the erect penis does not return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Priapism
Chinese translation: 阴茎持续勃起
has_MedDRA_id: 10036661

gingival bleeding AE
type: Class
subclass of: hemorrhage AE
definition: Gingival bleeding AE is a hemorrhage AE that is a term used by dentists and dental hygienists when referring to bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus, or interface between the gingiva and a tooth. Bleeding on probing, often abbreviated BOP, is a sign of inflammation and indicates some sort of destruction and erosion to the lining of the sulcus or the ulceration of sulcular epithelium. The blood comes from lamina propria after the ulceration of the lining.
definition editor: JX, LW, YH
alternative term: bleeding gums AE
alternative term: bleeding on probing AE
definition source: WEB: http://en.wikipedia.org/wiki/Bleeding_on_probing
Chinese translation: 牙龈出血
has_MedDRA_id: 10018276

hearing loss AE
type: Class
subclass of: hearing disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a hearing disorder AE that is a partial or total inability to hear. In children it may affect the development of language and can cause work related difficulties for adults.
definition editor: JX, LW, YH
alternative term: anacusis AE
alternative term: deafness AE
alternative term: hard of hearing AE
alternative term: hearing impaired AE
alternative term: hearing impairment AE
definition source: WEB: http://en.wikipedia.org/wiki/Hearing_loss
Chinese translation: 听力下降
has_MedDRA_id: 10019245
has_MedDRA_id: 10019246
see also: CTCAE: E10276
see also: NCIt: C50576

muscle fatigue AE
type: Class
subclass of: muscle AE
definition: Muscle fatigue AE is a muscle adverse event that is the decline in ability of a muscle to generate force. It can be a result of vigorous exercise but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction.
definition editor: JX, LW, YH
alternative term: physical fatigue AE
definition source: WEB: http://en.wikipedia.org/wiki/Muscle_fatigue
Chinese translation: 肌肉疲劳
has_MedDRA_id: 10049565

regurgitation AE
type: Class
subclass of: digestive system AE
definition: Regurgitation AE is a digestive system AE that is the expulsion of material from the pharynx, or esophagus, usually characterized by the presence of undigested food or blood.
definition editor: JX, LW, YH
definition source: http://en.wikipedia.org/wiki/Regurgitation_%28digestion%29
Chinese translation: 反胃
has_MedDRA_id: 10067171

skin irritation AE
type: Class
subclass of: skin AE
definition: Skin irritation AE is a skin AE that is a mild inflammatory dermal tissue reaction, it can be caused by physical contact with an irritant or can be a local response to a systemic trigger.
definition editor: JX, LW, YH
Chinese translation: 皮肤刺激
has_MedDRA_id: 10040880

herpes simplex AE
type: Class
subclass of: OAE_0003233
definition: a herpes viral infection AE tha is caused by both Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2).
definition editor: JX, LW, YH
alternative term: herpes catarrhalis AE
definition source: WEB: http://en.wikipedia.org/wiki/Herpes_simplex
Chinese translation: 单纯疱疹
has_MedDRA_id: 10019948

measles AE
type: Class
subclass of: viral infection AE
definition: Measles AE is a viral infection AE is an infection of the respiratory system, immune system and skin caused by a virus, specifically a paramyxovirus of the genus Morbillivirus.
definition editor: JX, LW, YH
alternative term: English measles AE
alternative term: morbilli AE
alternative term: rubeola AE
definition source: WEB: http://en.wikipedia.org/wiki/Measles
Chinese translation: 麻疹
has_MedDRA_id: 10027011

hypercholesteremia AE
type: Class
subclass of: blood cholesterol abnormal AE
definition: Hypercholesteremia AE is a blood cholesterol abnormal AE that is the presence of high levels of cholesterol in the blood.
definition editor: JX, LW, YH
alternative term: cholesterol high AE
alternative term: dyslipidemia
alternative term: hypercholesterolemia AE
definition source: WEB: http://en.wikipedia.org/wiki/Hypercholesterolemia
Chinese translation: 高胆固醇血症
has_MedDRA_id: 10005425
has_MedDRA_id: 10008661
has_MedDRA_id: 10020604

toxic epidermal necrolysis AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: Toxic epidermal necrolysis AE is a skin AE that is a rare, life-threatening skin condition which is usually caused by a reaction to drugs.
definition editor: JX, LW, YH, MW
alternative term: Lyell's syndrome AE
definition source: WEB: http://en.wikipedia.org/wiki/Toxic_epidermal_necrolysis
Chinese translation: 中毒性表皮坏死溶解症
has_MedDRA_id: 10044223

atrioventricular junctional rhythm AE
type: Class
subclass of: arrhythmia AE
definition: Atrioventricular junctional rhythm AE is an arrhythmia AE that is an electrocardiographic finding in which the pacer of the heart is located in the AV junction, presenting with a narrow QRS complex and a rate of 40-60 beats per minute.
definition editor: JX, LW, YH
Chinese translation: 房室交界性心律

unconsciousness AE
type: Class
subclass of: sensory capability AE
definition: Unconsciousness AE is a sensory capability AE that is a state which occurs when the ability to maintain a awareness of self and environment is lost, it involves a complete or near-complete lack of responsiveness to people and other environmental stimuli.
definition editor: JX, LW, YH
alternative term: loss of consciousness AE
definition source: WEB: http://en.wikipedia.org/wiki/Unconsciousness
Chinese translation: 意识丧失
has_MedDRA_id: 10045481

pemphigus AE
type: Class
subclass of: skin AE
definition: Pemphigus AE is a skin AE that is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Pemphigus
Chinese translation: 天疱疮
has_MedDRA_id: 10034280

onychomycosis AE
type: Class
subclass of: nail infection AE
definition: Onychomycosis AE is a nail infection AE that is a fungal infection of the nail. It is the most common disease of the nails and constitutes about half of all nail abnormalities.
definition editor: JX, LW, YH
alternative term: dermatophytic onychomycosis AE
alternative term: tinea unguium AE
definition source: WEB: http://en.wikipedia.org/wiki/Onychomycosis
Chinese translation: 甲癣

miosis AE
type: Class
subclass of: eye AE
definition: Miosis AE is an eye AE that is a term with various definitions, which generally include constriction of the pupil.
definition editor: JX, LW, YH
alternative term: myosis AE
definition source: WEB: http://en.wikipedia.org/wiki/Miosis
Chinese translation: 瞳孔缩小
has_MedDRA_id: 10027646

optic atrophy AE
type: Class
subclass of: optic neuropathy AE
definition: an optic neuropathy AE that shows the loss of some or most of the nerve fibers in the optic nerve. The effects range from visual change to severe visual loss.
definition editor: JX, LW, YH
definition source: WEB: http://www.kellogg.umich.edu/patientcare/conditions/optic.atrophy.html
Chinese translation: 视神经萎缩
has_MedDRA_id: 10030910

albuminuria AE
type: Class
subclass of: urine abnormality AE
definition: Albuminuria AE is a urine abnormality AE that is a pathological condition wherein albumin is present in the urine. It is a type of proteinuria.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Albuminuria
Chinese translation: 蛋白尿
has_MedDRA_id: 10001580

enuresis AE
type: Class
subclass of: urine abnormality AE
definition: Enuresis AE is a urine abnormality AE that refers to a repeated inability to control urination. Use of the term is usually limited to describing individuals old enough to be expected to exercise such control.
editor note: This term appears to be a synonym to the 'urinary incontinence AE'.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Enuresis
Chinese translation: 遗尿
has_MedDRA_id: 10014928

gum hypertrophy AE
type: Class
subclass of: digestive system AE
definition: Gum hypertrophy AE is a digestive system AE that is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications.
definition editor: JX, LW, YH
alternative term: gingival enlargement AE
alternative term: gingival hyperplasia AE
alternative term: gingival hypertrophy AE
alternative term: gingival over-growth AE
alternative term: hypertrophic gingivitis AE
definition source: WEB: http://en.wikipedia.org/wiki/Gingival_enlargement
Chinese translation: 牙龈增生
has_MedDRA_id: 10018781

contact dermatitis AE
type: Class
subclass of: dermatitis AE
definition: Contact dermatitis AE is a dermatitis AE that is a type of skin inflammation.It results from exposure to allergens (allergic contact dermatitis) or irritants (irritant contact dermatitis). Phototoxic dermatitis occurs when the allergen or irritant is activated by sunlight.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Contact_dermatitis
Chinese translation: 接触性皮炎
has_MedDRA_id: 10010790

necrotizing vasculitis AE
type: Class
subclass of: vasculitis AE
definition: Necrotizing vasculitis AE is a vasculitis AE that is a rare condition which involves inflammation of the blood vessel walls.
definition editor: JX, LW, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000432.htm
Chinese translation: 坏死性血管炎
has_MedDRA_id: 10028892

carpal tunnel syndrome AE
type: Class
subclass of: peripheral neuropathy AE
definition: Carpal tunnel syndrome AE is a peripheral neuropathy AE that is a median entrapment neuropathy that causes paresthesia, pain, numbness, and other symptoms in the distribution of the median nerve due to its compression at the wrist in the carpal tunnel.
definition editor: JX, LW, YH
alternative term: median nerve neuropathy AE
definition source: WEB: http://emedicine.medscape.com/article/1141168-clinical#showall
definition source: WEB: http://en.wikipedia.org/wiki/Carpal_tunnel_syndrome
Chinese translation: 腕管综合征
has_MedDRA_id: 10007697

erythromelalgia AE
type: Class
subclass of: peripheral arterial disease AE
definition: Erythromelalgia AE is a peripheral arterial disease AE that is a rare neurovascular peripheral pain disorder in which blood vessels, usually in the lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and inflamed.
definition editor: JX, LW, YH
alternative term: Mitchell's disease AE
alternative term: acromelalgia AE
alternative term: erythermalgia AE
alternative term: red neuralgia AE
definition source: WEB: http://en.wikipedia.org/wiki/Erythromelalgia
Chinese translation: 红斑性肢痛症
has_MedDRA_id: 10015284

Raynaud's syndrome AE
type: Class
subclass of: syndrome AE
definition: a syndrome AE which results in the Raynaud's syndrome, a rare disease causes some areas of your body — such as your fingers and toes — to feel numb and cold in response to cold temperatures or stress. In Raynaud's disease, smaller arteries that supply blood to your skin narrow, limiting blood circulation to affected areas (vasospasm).
definition editor: JX, LW, YH
alternative term: Raynaud's disease AE
alternative term: Raynaud's phenomenon AE
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/raynauds-disease/basics/definition/con-20022916
Chinese translation: 雷诺综合症
has_MedDRA_id: 10037914

extrapyramidal syndrome AE
type: Class
subclass of: nervous system AE
definition: Extrapyramidal syndrome AE is a nervous system AE that is drug induced movement disorders which include acute and tardive symptoms.
definition editor: JX, LW, YH
alternative term: extrapyramidal side effects AE
alternative term: vertebral body outside the beam syndrome AE
definition source: WEB: http://en.wikipedia.org/wiki/Extrapyramidal_symptoms
Chinese translation: 椎体外系综合征
has_MedDRA_id: 10015836

sodium retention AE
type: Class
subclass of: electrolyte lab test abnormal AE
definition: an electrolyte lab test abnormal AE that is when the kidneys hold on to more sodium and do not excrete it with the kidneys. This tends to expand the blood volume, which can elevate the blood pressure.
definition editor: JX, LW, YH
definition source: WEB: https://answers.yahoo.com/question/index?qid=20100823074826AAcg7WV
Chinese translation: 钠潴留
has_MedDRA_id: 10041277

complex regional pain syndrome AE
type: Class
subclass of: pain AE
definition: complex regional pain syndrome AE is a pain AE that results in an uncommon form of chronic pain that usually affects an extremity.
definition editor: SJ, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/complex-regional-pain-syndrome/basics/definition/con-20022844
has_MedDRA_id: 10064332
comment: Complex regional pain syndrome typically develops after an injury, surgery, stroke or heart attack, but the pain is out of proportion to the severity of the initial injury.

sciatica AE
type: Class
subclass of: pain AE
definition: Sciatica AE is a pain AE that is a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve or by compression or irritation of the left or right or both sciatic nerves.
definition editor: JX, LW, YH
alternative term: lumbar radiculopathy AE
alternative term: sciatic neuralgia AE
alternative term: sciatic neuritis AE
definition source: WEB: http://en.wikipedia.org/wiki/Sciatica
Chinese translation: 坐骨神经痛
has_MedDRA_id: 10039674

joint stiffness AE
type: Class
subclass of: joint disorder AE
definition: Joint stiffness AE is a joint disorder AE that may be either the symptom of pain on moving a joint, the symptom of loss of range of motion or the physical sign of reduced range of motion.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Joint_stiffness
Chinese translation: 关节僵硬
has_MedDRA_id: 10023230

breast engorgement AE
type: Class
subclass of: reproductive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000310
definition: Breast engorgement AE is a reproductive system AE that occurs in the mammary glands due to expansion and pressure exerted by the synthesis and storage of breast milk.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Breast_engorgement
Chinese translation: 乳房充盈
has_MedDRA_id: 10006240

nervous tension AE
type: Class
subclass of: behavioral and neurological AE
definition: Nervous tension AE is a behavior and neurological AE that might be said to be a physical expression of how people deal with negatively experienced emotion.
definition editor: JX, LW, YH
definition source: WEB: http://helpmetosleep.org/featured-articles/how-to-relieve-nervous-tension/
Chinese translation: 神经紧张
has_MedDRA_id: 10029214

nervousness AE
type: Class
subclass of: behavioral and neurological AE
definition: Nervousness AE is a behavior and neurological AE that shows an uneasy psychological state which including anxiety, neurosis, neuroticism, and worry, etc.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Nervousness
Chinese translation: 神经过敏
has_MedDRA_id: 10029216

osteoarthritis AE
type: Class
subclass of: arthritis AE
definition: Osteoarthritis AE is an arthritis AE that is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Osteoarthritis is not an inflammatory disease even-though the name suggest one. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion.
definition editor: JX, LW, YH
alternative term: degenerative arthritis AE
alternative term: degenerative joint disease AE
alternative term: osteoarthrosis AE
definition source: WEB: http://en.wikipedia.org/wiki/Osteoarthritis
Chinese translation: 骨关节炎
has_MedDRA_id: 10031161

methemoglobinemia AE
type: Class
subclass of: red blood cell profile abnormal AE
definition: Methemoglobinemia AE is a red blood cell profile abnormal AE that is a disorder characterized by the presence of a higher than normal level of methemoglobin (metHb, i.e., ferric [Fe3+] rather than ferrous [Fe2+] haemoglobin) in the blood. It's a form of hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to bind oxygen.
definition editor: JX, LW, YH
alternative term: methaemoglobinaemia AE
definition source: WEB: http://en.wikipedia.org/wiki/Methemoglobinemia
Chinese translation: 高铁血红蛋白症
has_MedDRA_id: 10027506

hemiageusia AE
type: Class
subclass of: ageusia AE
definition: Hemiageusia AE is a ageusia AE that shows loss of taste from one side of the tongue.
definition editor: JX, LW, YH
alternative term: hemiageustia AE
alternative term: hemigeusia AE
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=39885
Chinese translation: 偏侧味觉缺失

skin swelling AE
type: Class
subclass of: edema AE
definition: Skin swelling AE is an edema AE that has an outcome of the occurrence of swelling which is located on the skin.
definition editor: JX, LW, YH
definition source: WEB: http://www.rightdiagnosis.com/sym/skin_swelling.htm
Chinese translation: 胕肿
has_MedDRA_id: 10053262

fibrosing alveolitis AE
type: Class
subclass of: lung inflammation AE
definition: Fibrosing alveolitis AE is a lung inflammation AE that is a disease of unknown cause mainly involving the gas-exchanging portions of the lungs. It may occur in isolation and be called cryptogenic or idiopathic, in which case the clinical manifestations are mainly respiratory, or it may be associated with other disorders, such as rheumatoid arthritis.
definition editor: JX, LW, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1818528/
Chinese translation: 纤维化肺泡炎
has_MedDRA_id: 10016640

hypochloremic alkalosis AE
type: Class
subclass of: electrolyte lab test abnormal AE
definition: an electrolyte chloride abnormal AE where the patient's body has abnormally low levels of chloride. This condition usually results from an extremely high loss of chloride, rather than a low intake of it.
definition editor: JX, LW, YH
definition source: WEB: http://www.wisegeek.com/what-is-hypochloremic-alkalosis.htm
Chinese translation: 低氯性碱中毒
has_MedDRA_id: 10020958

erythema annulare centrifugum AE
type: Class
subclass of: erythema AE
definition: Erythema annulare centrifugum AE is an erythema AE that is a descriptive term for a skin lesion. The lesions form consists of redness (erythema) in a ring form (anulare) that spreads from the center (centrifugum).
definition editor: JX, LW, YH
alternative term: MedDRA: 10015154
alternative term: deep gyrate erythema AE
alternative term: erythema perstans AE
alternative term: palpable migrating erythema AE
alternative term: superficial gyrate erythema AE
definition source: WEB: http://en.wikipedia.org/wiki/Erythema_annulare_centrifugum
Chinese translation: 离心性环形红斑

irritation AE
type: Class
subclass of: behavioral and neurological AE
definition: Irritation is a behavior and neurological AE that is a state of inflammation or painful reaction to allergy or cell-lining damage.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Irritation
Chinese translation: 刺激
has_MedDRA_id: 10029216

neuroticism AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that is a fundamental personality trait in the study of psychology characterized by anxiety, fear, moodiness, worry, envy, frustration, jealousy, and loneliness.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Neuroticism
Chinese translation: 神经质

hyperirritability AE
type: Class
subclass of: behavioral and neurological AE
definition: Hyperirritability AE is a behavior and neurological AE that shows abnormally great or uninhibited response to stimuli.
editor note: This term appears to be a synonym to the 'irritability AE'.
definition editor: JX, LW, YH
definition source: WEB: http://www.merriam-webster.com/medical/hyperirritability; http://en.wikipedia.org/wiki/Irritability
Chinese translation: 过激

rhinostenosis AE
type: Class
subclass of: respiratory system AE
definition: Rhinostenosis AE is a respiratory system AE that shows narrowing or obliteration of the nasal airway by scar formation
definition editor: JX, LW, YH
definition source: WEB: http://www.drugs.com/dict/rhinostenosis.html
comment: 鼻道狭窄

sino-auricular heart-block AE
type: Class
subclass of: conduction system disorder AE
definition: Sino-auricular heart-block AE is a conduction system disorder AE that refers to a rare heart condition caused by abnormalities in the heart's electrical system rather than arterial disease.
definition editor: JX, LW, YH
definition source: WEB: http://www.rightdiagnosis.com/s/sino_auricular_heart_block/intro.htm
Chinese translation: 窦房传导阻滞

anisosphygmia AE
type: Class
subclass of: cardiovascular AE
definition: Anisosphygmia AE is a cardiovascular disorder AE that shows difference in volume, force, or time of the pulse in the corresponding arteries on two sides of the body, the two radials, or femorals.
definition editor: JX, LW, YH
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=4352
Chinese translation: 脉搏不规则

rubefaction AE
type: Class
subclass of: skin AE
definition: Rubefaction AE is a skin AE that refers to erythema of the skin caused by local application of a counterirritant.
definition editor: JX, LW, YH
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=79112
Chinese translation: 发红

myodystony AE
type: Class
subclass of: abnormal muscle tone AE
definition: Myodystony AE is an abnormal muscle tone AE that refers to a condition of slow relaxation, interrupted by a succession of slight contractions, following electrical stimulation of a muscle.
definition editor: JX, LW, YH
definition source: WEB: http://www.drugs.com/dict/myodystony.html
Chinese translation: 肌张力不全

allotriosmia AE
type: Class
subclass of: behavioral and neurological AE
definition: Allotriosmia is a behavior and neurological AE that shows incorrect recognition of odors.
definition editor: JX, LW, YH
alternative term: heterosmia AE
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=2401
Chinese translation: 嗅觉异常
has_MedDRA_id: 10029216

pharyngotonsillitis AE
type: Class
subclass of: inflammation AE
definition: Pharyngotonsillitis is an inflammation AE that is a medical condition characterized by an inflammation of both the tonsils and the pharynx (located at the back of the throat). It occurs due to viral or bacterial infections.
definition editor: JX, LW, YH
definition source: WEB: http://www.persify.com/en/perspectives/medical-conditions-diseases/pharyngotonsillitis-_-951000101807
Chinese translation: 咽扁桃体炎
has_MedDRA_id: 10049140

hypersensitivity pneumonitis AE
type: Class
subclass of: pneumonia AE
definition: Hypersensitivity pneumonitis AE is a pneumonia AE that is an inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. Sufferers are commonly exposed to the dust by their occupation or hobbies.
definition editor: JX, LW, YH
alternative term: extrinsic allergic alveolitis AE
definition source: WEB: http://en.wikipedia.org/wiki/Hypersensitivity_pneumonitis
Chinese translation: 过敏性肺炎
has_MedDRA_id: 10015887

stagger AE
type: Class
subclass of: movement disorder AE
definition: Stagger AE is a movement disorder AE that shows an unsteady movement of the body in walking or standing, as if one were about to fall.
definition editor: JX, LW, YH
definition source: WEB: http://en.wiktionary.org/wiki/stagger
Chinese translation: 蹒跚

myocardial anoxia AE
type: Class
subclass of: hypoxia AE
definition: Myocardial anoxia AE is a hypoxia AE that shows a reduced concentration of O2 in the myocardium.
definition editor: JX, LW, YH
Chinese translation: 心肌缺氧

biliary colic AE
type: Class
subclass of: pain AE
definition: Biliary colic AE is a pain AE that is the term used to describe a type of pain related to the gallbladder that occurs when a gallstone transiently obstructs the cystic duct and the gallbladder contracts.
definition editor: JX, LW, YH
alternative term: cholecystalgia AE
definition source: WEB: http://en.wikipedia.org/wiki/Biliary_colic
Chinese translation: 胆绞痛
has_MedDRA_id: 10004663

hyperemia AE
type: Class
subclass of: cardiovascular AE
definition: Hyperemia AE is a cardiovascular disorder AE that is the increase of blood flow to different tissues in the body. It can have medical implications, but is also a regulatory response, allowing change in blood supply to different tissues through vasodilation.
definition editor: JX, LW, YH
alternative term: hyperaemia AE
definition source: WEB: http://en.wikipedia.org/wiki/Hyperaemia
Chinese translation: 充血

tenderness AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome increased sensitivity to pain in a patient
definition editor: RR
definition source: WEB: http://www.oxforddictionaries.com/us/definition/american_english/tenderness
has_MedDRA_id: 10043224

induration AE
type: Class
subclass of: skin AE
definition: a skin AE with the outcome of induration, which is an increase in the fibrous elements in tissue commonly associated with inflammation and marked by loss of elasticity and pliability or a hardened mass or formation
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/medical/induration
has_MedDRA_id: 10060708

foreign body sensation in eyes AE
type: Class
subclass of: eye AE
definition: an eye AE which has an outcome of a foreign body sensation in the eye, or the sensation that something is in or scratching the eye
definition editor: RR
definition source: WEB: http://www.richmondeye.com/eyehealth_foreignbody/
has_MedDRA_id: 10051116

injection site cellulitis AE
type: Class
subclass of: cellulitis AE
subclass of: injection-site AE
subclass of: Restriction
  on property: AE occurs in
  some values from: VO_0000300
definition: a cellulititis AE that occurs at an injection-site.
definition editor: RR
definition source: WEB: http://www.nhs.uk/Conditions/Cellulitis/Pages/Symptoms.aspx
has_MedDRA_id: 10050057

peripheral coldness AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of peripheral coldness, or coldness of extremeties
definition editor: RR
definition source: WEB: http://www.patient.co.uk/leaflets/peripheral_coldness.htm
has_MedDRA_id: 10034568

hypoesthesia facial AE
type: Class
subclass of: hypoesthesia AE
definition: a hypoaesthesia AE that has an outcome of a decrease in facial sensitivity
definition editor: RR
alternative term: hypoaesthesia facial AE
alternative term: hypoesthesia facial AE
definition source: WEB: http://www.webster-dictionary.org/definition/hypoesthesia
has_MedDRA_id: 10065312

poor quality sleep AE
type: Class
subclass of: sleep disorder AE
definition: a sleep disorder AE that shows poor quality sleep
definition editor: RR
has_MedDRA_id: 10062519

vesicular rash AE
type: Class
subclass of: rash AE
definition: a rash AE characterized by the formation of vesicles
definition editor: RR
alternative term: rash vesicular AE
definition source: WEB: http://www.merriam-webster.com/medical/vesicular
has_MedDRA_id: 10037898

limb discomfort AE
type: Class
subclass of: discomfort AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002101
definition: a discomfort AE that occurs at a limb
definition editor: RR
has_MedDRA_id: 10061224

scleral discoloration AE
type: Class
subclass of: eye AE
definition: an eye disorder AE which has an outcome of discoloration of the sclera, or the whites of the eyes
definition editor: RR
alternative term: scleral discolouration AE
has_MedDRA_id: 10039696

injection site urticaria AE
type: Class
subclass of: injection-site AE
subclass of: urticaria AE
subclass of: Restriction
  on property: AE occurs in
  some values from: VO_0000300
definition: an urticaria AE that occurs in an injection site
definition editor: RR
definition source: WEB: http://www.uptodate.com/contents/hives-urticaria-beyond-the-basics
has_MedDRA_id: 10022107

dysstasia AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in dysstasia, or difficulty standing
definition editor: RR
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=27458
has_MedDRA_id: 10050256

hyperesthesia AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of hyperaesthesia, meaning unusual or pathological sensitivity of the skin or of a particular sense
definition editor: RR
alternative term: hyperaesthesia AE
definition source: WEB: http://www.merriam-webster.com/dictionary/hyperesthesia
Chinese translation: 神经过敏
has_MedDRA_id: 10020568

nuclear magnetic resonance imaging spinal cord abnormal AE
type: Class
subclass of: nuclear magnetic resonance imaging result abnormal AE
definition: a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the spinal cord
definition editor: RR
has_MedDRA_id: 10069585

ocular icterus AE
type: Class
subclass of: eye AE
definition: an eye disorder AE which has an outcome of ocular icterus, or jaundice of the eye
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/dictionary/icterus
has_MedDRA_id: 10058117

edema mouth AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000165
definition: An edema AE that occurs in the mouth
definition editor: RR
alternative term: oedema mouth AE
has_MedDRA_id: 10030110

painful respiration AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE which has an outcome of painful respiration, an unpleasant sensation ranging from mild discomfort to unbearable agony while breathing
definition editor: RR
definition source: WEB: http://www.healthline.com/health/painful-respiration
has_MedDRA_id: 10033517

ophthalmological examination abnormal AE
type: Class
subclass of: behavioral and neurological test abnormal AE
definition: a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal ophthalmological examination
definition editor: RR
has_MedDRA_id: 10056836

ischemic optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
definition: an optic neuropahty AE which shows an infarction of the optic disk which presents as painless vision loss
definition editor: RR
alternative term: optic ischemic neuropathy AE
definition source: WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/
definition source: WEB: http://www.merckmanuals.com/professional/eye_disorders/optic_nerve_disorders/ischemic_optic_neuropathy.html
has_MedDRA_id: 10030924

lyme disease AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE with an outcome of Lyme disease, a tick-bourne illness cause by the bacterium B. burgdorferi that causes dermatologic, rheumatologic, neurologic, and cardiac abnormalities
definition editor: RR
definition source: WEB: http://wwwn.cdc.gov/nndss/script/casedef.aspx?CondYrID=752&DatePub=1/1/2011
has_MedDRA_id: 10025169

lymph node pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of lymph node pain
definition editor: RR
has_MedDRA_id: 10025182
see also: CTCAE: E10052
see also: NCIt: C78440

loss of control of legs AE
type: Class
subclass of: movement disorder AE
definition editor: RR
has_MedDRA_id: 10024860
comment: a movement disorder AE that has an outcome of loss of control of patient's legs

livedo reticularis AE
type: Class
subclass of: vascular disorder AE
definition: a vascular disorder AE that has an outcome of levedo reticularis, a condition of the peripheral blood vessels characterized by reddish blue mottling of the skin especially of the extremeties usually upon exposure to cold
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/medical/livedo%20reticularis
has_MedDRA_id: 10024648

muscle strain AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event AE that has an outcome of muscle strain, which happens when a muscle is stretched too much and tears
definition editor: RR
alternative term: pulled muscle AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001109/
has_MedDRA_id: 10050031

muscle tightness AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event AE that has an outcome of muscle tightness, which is a tense feeling in muscles
definition editor: RR
definition source: WEB: http://www.chirocommunity.com/muscletightness.htm
has_MedDRA_id: 10049816

muscle rigidity AE
type: Class
subclass of: muscle AE
definition: a muscle adverse event AE that has an outcome of muscle rigidity, a state of continuous firm, tense muscles with marked resistance to passive movement
definition editor: RR
definition source: WEB: http://www.healthline.com/symptom/muscle-rigidity
Chinese translation: 肌肉僵硬
has_MedDRA_id: 10028330

Miller Fisher syndrome AE
type: Class
subclass of: Guillain-Barre syndrome AE
definition: Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barre syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes
definition editor: RR
definition source: WEB: http://www.ninds.nih.gov/disorders/miller_fisher/miller_fisher.htm
has_MedDRA_id: 10049567

type III immune complex mediated reaction AE
type: Class
subclass of: injection-site AE
subclass of: hypersensitivity AE
subclass of: Restriction
  on property: occurs in
  some values from: VO_0000300
definition: a hypersensitivity AE which has an outcome of type III immune complex mediated reaction, a type of hypersensitivity reaction in which circulating antigen-antibody immune complexes are deposited in post-capillary venules, with subsequent complement fixation
definition editor: RR
definition source: WEB: http://emedicine.medscape.com/article/136217-overview
has_MedDRA_id: 10053614

tonsilar hypertrophy AE
type: Class
subclass of: tonsillitis AE
definition: a tonsilitis AE with the outcome of tonsilar hypertrophy, or enlargement of the tonsils
definition editor: RR
definition source: WEB: http://www.cchi.com.hk/symposia/s3_ear_1.htm
has_MedDRA_id: 10044003

temperature intolerance AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition: a sensory capability AE that results in temperature intolerance
definition editor: RR
has_MedDRA_id: 10057040

unresponsive to stimuli AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition: a sensory capability AE that results in the patient being unresponsive to stimuli
definition editor: RR
has_MedDRA_id: 10045555

sputum discolored AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that shows discolored sputum
definition editor: RR
has_MedDRA_id: 10041806

spinal column stenosis AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal system AE that has an outcome of spinal column stenosis, or narrowing of spaces in the spine that results in pressure on the spinal cord and/or nerve roots
definition editor: RR
definition source: WEB: http://www.niams.nih.gov/Health_Info/Spinal_Stenosis/
has_MedDRA_id: 10041540

skin tightness AE
type: Class
subclass of: skin AE
definition: a skin AE with the outcome of skin tightness
definition editor: RR
has_MedDRA_id: 10050637

ligament pain AE
type: Class
subclass of: pain AE
definition: a pain AE with the outcome of ligament pain
definition editor: RR
has_MedDRA_id: 10068790

idiopathic thrombocytopenic purpura AE
type: Class
subclass of: thrombocytopenic purpura AE
definition: a thrombocytopenic purpura AE with no known cause (idiopathic). Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necesssary for normal blood clotting. Persons with this disorder have too few platelets in the blood.
definition editor: RR
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000535.htm
Chinese translation: 特发性血小板减少性紫癜
has_MedDRA_id: 10021245

cerebral palsy AE
type: Class
subclass of: OAE_0004344
definition: A palsy AE that shows cerebral palsy, a disorder of movement, muscle tone, or posture that is caused by an insult to the immature, developing brain, most often before birth
definition editor: RR
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/cerebral-palsy/basics/definition/con-20030502
has_MedDRA_id: 10008129

chronic inflammatory demyelinating polyradiculoneuropathy AE
type: Class
subclass of: neuropathy AE
definition: a neurological AE with the outcome of chronic inflammatory demyelinating polyradiculoneuropathy, a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms caused by damage to the myelin sheath of the peripheral nerves
definition editor: RR
definition source: WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm
has_MedDRA_id: 10057645

allergic dermatitis AE
type: Class
subclass of: allergy AE
definition: an allergy AE which displays an allergic skin response following contact of an allergen, with the skin typically marked by an itchy red rash often accompanied by swelling and watery blisters.
definition editor: RR, JX, YH
alternative term: dermatitis allergic AE
definition source: WEB: http://www.merriam-webster.com/dictionary/allergic%20contact%20dermatitis
has_MedDRA_id: 10012434

diet refusal AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE with an outcome of the patient refusing to eat
definition editor: RR
has_MedDRA_id: 10012775

blood pressure fluctuation AE
type: Class
subclass of: abnormal blood pressure AE
definition: an abnormal blood pressure AE that has an outcome of blood pressure fluctuations
definition editor: RR
has_MedDRA_id: 10005746

aphagia AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE which has an outcome of aphagia, which is the loss of the ability to swallow
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/medical/aphagia
has_MedDRA_id: 10049866

aphonia AE
type: Class
subclass of: speech disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a speech disorder AE with an outcome of aphonia, or loss of voice and of all but whispered speech
definition editor: RR, MW
definition source: WEB: http://www.merriam-webster.com/dictionary/aphonia
has_MedDRA_id: 10002953

abdominal pain lower AE
type: Class
subclass of: OAE_0003346
definition: a stomach pain AE that is observed in lower stomach
definition editor: RR
definition source: WEB: http://www.mayoclinic.org/symptoms/abdominal-pain/basics/definition/sym-20050728
has_MedDRA_id: 10000084

abnormal sensation in eye AE
type: Class
subclass of: eye AE
definition: an eye AE with an outcome of an abnormal sensation in the eye
definition editor: RR
has_MedDRA_id: 10000173

impaired driving ability AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE which has an outcome of impaired driving ability
definition editor: RR
has_MedDRA_id: 10049564

increased bronchial secretion AE
type: Class
subclass of: respiratory system AE
definition: a respiratory system AE that has an outcome of increased bronchial secretion, or an increase in the substance produced in the bronchial tree, which includes mucus, protein salts, plasma fluid, and proteins
definition editor: RR
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bronchial+secretion
has_MedDRA_id: 10062530

injection site streaking AE
type: Class
subclass of: injection-site AE
definition: an injection-site AE that displays injection site streaking, a red pattern on the skin localized to the injection site
definition editor: RR
definition source: WEB: http://www.bannerhealth.com/incfiles/housecalls/peds/FeverInfectionsCrying/ImmunizationReactions.htm
has_MedDRA_id: 10066778

injection site vesicles AE
type: Class
subclass of: injection-site AE
definition: an injection-site AE that displays injection site streaking, which are small, fluid-filled blisters localized to the injection site
definition editor: RR
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003939.htm
has_MedDRA_id: 10022111

international normalized ratio increased AE
type: Class
subclass of: hematology investigation result abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a lab test abnormal AE that has an outcome of an increased international normalized ratio, indicating an individual is more prone to bleeding
definition editor: RR, MW, YH
alternative term: INR increased AE
definition source: WEB: http://circ.ahajournals.org/content/126/5/e52.full
has_MedDRA_id: 10022402
has_MedDRA_id: 10022595
see also: CTCAE: E12175
see also: NCIt: C78366

irregular sleep phase AE
type: Class
subclass of: sleep disorder AE
definition: a sleep disorder AE with the outcome of irregular sleep phase, which is an abnormality in the timing of sleep
definition editor: RR
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/delayed-sleep-phase/basics/definition/con-20035242
has_MedDRA_id: 10022995

injection site anesthesia AE
type: Class
subclass of: injection-site AE
definition: an injection-site AE that displays injection site anesthesia, or numbness at the injection site
definition editor: RR
has_MedDRA_id: 10022047

injection site infection AE
type: Class
subclass of: infection AE
subclass of: injection-site AE
subclass of: Restriction
  on property: AE occurs in
  some values from: VO_0000300
definition: an infection AE that occurs at an injection-site
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/dictionary/infection
has_MedDRA_id: 10022076

grip strength decreased AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE which has an outcome of decreased grip strength, or a reduction in the force applied by the hand to pull on or suspend from objects
definition editor: RR
definition source: WEB: http://www.krepublishers.com/02-Journals/JLS/JLS-01-0-000-09-Web/JLS-01-1-000-09-Abst-PDF/JLS-01-01-057-09-020-Koley-S/JLS-01-01-057-09-020-Koley-S-Tt.pdf
has_MedDRA_id: 10062556

eyelid margin crusting AE
type: Class
subclass of: eyelid disorder AE
definition: an eye AE with the outcome of eyelid margin crusting
definition editor: RR
has_MedDRA_id: 10052132

ear discomfort AE
type: Class
subclass of: ear AE
definition: an ear AE with the outcome of ear discomfort, an uncomfortable or painful feeling in the ear
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/dictionary/discomfort
has_MedDRA_id: 10052137

fecal incontinence AE
type: Class
subclass of: abnormal defecation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an abnormal defecation AE that has an outcome of fecal incontinence, the accidental passing of solid or liquid stool or mucus from the rectum
definition editor: RR, MW, YH
alternative term: faecal incontinence AE
definition source: WEB: http://digestive.niddk.nih.gov/ddiseases/pubs/fecalincontinence/#what
has_MedDRA_id: 10016092
has_MedDRA_id: 10016296
see also: CTCAE: E10693
see also: NCIt: C78498

fear AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that has an outcome of fear, which is to be afraid and/or worried
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/dictionary/fear
has_MedDRA_id: 10016275

gingival pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has an outcome of pain in gums
definition editor: RR
definition source: WEB: http://www.merriam-webster.com/dictionary/gingival
has_MedDRA_id: 10018286
see also: CTCAE: E10763
see also: NCIt: C78325

glossitis AE
type: Class
subclass of: tongue disorder
definition: a tongue disorder with the outcome of glossitis, a condition in which the tongue is swollen and changes color, which may make the tongue appear smooth
definition editor: RR
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001053.htm
has_MedDRA_id: 10018386

muscle injury AE
type: Class
subclass of: injury AE
definition: an injury AE which has an outcome of muscle injury
definition editor: RR
has_MedDRA_id: 10028314

sensory disturbance AE
type: Class
subclass of: sensory capability AE
definition: a sensory capability AE that has an outcome of sensory disturbance
definition editor: RR
has_MedDRA_id: 10040026

tracheal edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0003126
definition: an edema AE with an outcome of tracheal edema, which is the swelling of the airway between the throat and the lungs
definition editor: RR
definition source: WEB: http://firstaidcalgary.ca/causes-of-tracheal-edema/
has_MedDRA_id: 10044296

allergic eruption AE
type: Class
subclass of: skin AE
definition: Allergic eruption AE is a skin AE that is most drug-induced cutaneous reactions, especially found in younger adults. Sometimes also be diagnosed with eczema.
editor note: This term appears to be a synonym to the 'eczema AE'.
definition editor: JX, LW, YH
Chinese translation: 过敏性皮疹

erythrodermia AE
type: Class
subclass of: skin AE
definition: Erythrodermia AE is a skin AE that is an inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface.
definition editor: JX, LW, YH
alternative term: dermatitis exfoliativa AE
alternative term: exfoliative dermatitis AE
alternative term: red man syndrome AE
definition source: WEB: http://en.wikipedia.org/wiki/Erythroderma
Chinese translation: 红皮病
has_MedDRA_id: 10037165

mycotic dermatitis AE
type: Class
subclass of: dermatitis AE
definition: Mycotic dermatitis is a dermatitis AE that is a inflammation of skin which induced by mycetes.
definition editor: JX, LW, YH
Chinese translation: 真菌性皮炎

peritendinitis symptom AE
type: Class
subclass of: inflammation AE
definition: Peritendinitis symptom AE is an inflammation AE that has an outcome of inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
definition editor: JX, LW, YH
Chinese translation: 腱鞘炎样症状

orthostatic hypotension AE
type: Class
subclass of: hypotension AE
definition: Orthostatic hypotension AE is a hypotension AE that is a form of hypotension in which a person's blood pressure falls when suddenly standing up or stretching. In medical terms, it is defined as a fall in systolic blood pressure of at least 20 mm Hg or diastolic blood pressure of at least 10 mm Hg when a person assumes a standing position.
definition editor: JX, LW, YH
alternative term: orthostasis AE
alternative term: postural hypotension AE
definition source: WEB: http://en.wikipedia.org/wiki/Orthostatic_hypotension
Chinese translation: 直立性低血压
has_MedDRA_id: 10031127

color vision deficiency AE
type: Class
subclass of: abnormal vision AE
definition editor: JX, LW, YH
alternative term: chromatopsia AE
definition source: WEB: http://ghr.nlm.nih.gov/condition/color-vision-deficiency
Chinese translation: 色视力缺乏
comment: Color vision deficiency AE is an abnormal vision AE that is a group of conditions that affect the perception of color. They cause a range of changes in color vision, from mild difficulty with distinguishing shades to a total inability to detect color. These conditions are divided into three major categories: red-green color vision defects, blue-yellow color vision defects, and a complete absence of color vision.

carcinogenesis AE
type: Class
subclass of: tumor AE
definition: Carcinogenesis AE is a tumor AE that is literally the 'creation' of cancer. It is a process by which normal cells are transformed into cancer cells.
definition editor: JX, LW, YH
alternative term: oncogenesis AE
alternative term: tumorigenesis AE
definition source: WEB: http://en.wikipedia.org/wiki/Carcinogenesis
Chinese translation: 致癌

anaphylactic shock AE
type: Class
equivalent class: Class
  intersection of: circulatory shock AE
  intersection of: anaphylaxis AE
subclass of: circulatory shock AE
definition: a circulatory AE that is a serious allergic reaction associated with systemic vasodilation that causes low blood pressure which is by definition 30% lower than the person's baseline or below standard values.
definition editor: JX, LW, YH, RR
definition source: WEB: http://en.wikipedia.org/wiki/Anaphylaxis
definition source: WEB: http://smschile.cl/documentos/cursos2010/MedicalClinicsNorthAmerica/Acute%20Symptoms%20of%20Drug%20Hypersensitivity%20%28Urticaria,%20Angioedema,%20Anaphylaxis,%20Anaphylactic%20Shock%29.pdf
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=10092
Chinese translation: 过敏性休克
has_MedDRA_id: 10002199

pituitary adenomas AE
type: Class
subclass of: tumor AE
definition: Pituitary adenomas AE is a tumor AE that is a tumor which occur in the pituitary gland. Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas, with carcinomas accounting for 0.1% to 0.2%, approximately 35% being invasive adenomas and most being benign adenomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Pituitary_adenoma

fatty infiltration AE
type: Class
subclass of: embolism AE
definition: Fatty infiltration AE is an embolism AE that shows the abnormal accumulation of fat droplets in the cytoplasm of cells.
definition editor: JX, LW, YH
definition source: WEB: http://dictionary.reference.com/browse/fatty+infiltration
Chinese translation: 脂肪侵润

epigastric discomfort AE
type: Class
subclass of: discomfort AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition: Epigastric discomfort is a discomfort AE that shows discomfort in the upper central region of the abdomen.
definition editor: JX, LW, YH
alternative term: upper Abdominal discomfort AE
definition source: WEB: http://www.rightdiagnosis.com/sym/epigastric_discomfort.htm
Chinese translation: 上腹部不适
has_MedDRA_id: 10053155

acute intravascular hemolysis AE
type: Class
subclass of: cardiovascular AE
definition: Acute intravascular hemolysis AE is a cardiovascular AE that has an outcome of disruption of red blood cells occurs while they are within blood vessels.
definition editor: JX, LW, YH
Chinese translation: 急性血管内溶血

allergic hepatitis AE
type: Class
subclass of: hepatitis AE
definition: Allergic hepatitis AE is a hepatitis AE that is a tissue-specific inflammatory diease caused by hepersensitivity to a particular drug, accomopanied by a systemic allergic reaction such as eosinophilia.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis
Chinese translation: 过敏性肝炎
has_MedDRA_id: 10071198

paranoid anxietas AE
type: Class
subclass of: anxiety AE
definition: Paranoid anxiety AE is a anxiety AE that is a term used in object relations theory, particularity in discussions about the Paranoid-schizoid and depressive positions. The term was frequently used by Melanie Klein, especially to refer to a pre-depressive and persecutory sense of anxiety characterised by the psychological splitting of objects.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Paranoid_anxiety
Chinese translation: 偏执性焦虑

thrombotic thrombocytopenic purpura AE
type: Class
subclass of: thrombocytopenic purpura AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Thrombotic thrombocytopenic purpura AE is a thrombocytopenic purpura AE that is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body.
definition editor: JX, LW, YH
alternative term: moschcowitz syndrome AE
definition source: WEB: http://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura
Chinese translation: 血栓性血小板减少性紫癜
has_MedDRA_id: 10043648
see also: CTCAE: E10061
see also: NCIt: C78797

glaucoma AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: Glaucoma AE is an eye AE that is a term describing a group of ocular (eye) disorders resulting in optic nerve damage or loss to the field of vision, in many patients caused by a clinically characterized pressure buildup in regards to the fluid of the eye (intraocular pressure-associated optic neuropathy).
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Glaucoma
Chinese translation: 青光眼
has_MedDRA_id: 10018304
see also: CTCAE: E10392
see also: NCIt: C26782

anaphylaxis AE
type: Class
subclass of: allergy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an allergy AE that shows a serious allergic reaction that is rapid in onset and may cause death. It typically causes a number of symptoms including an itchy rash, throat swelling, and low blood pressure. Common causes include insect bites and stings, foods, and medications.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Anaphylaxis
Chinese translation: 过敏症
has_MedDRA_id: 10002218
see also: CTCAE: E11254
see also: NCIt: C50460

seasonal allergy AE
type: Class
subclass of: allergy AE
definition: an allergy AE which occur during certain times of the year, usually when outdoor molds release their spores, and trees, grasses, and weeds release tiny pollen particles into the air to fertilize other plants.
definition editor: JX, LW, YH
definition source: WEB: http://kidshealth.org/parent/medical/allergies/seasonal_allergies.html
Chinese translation: 季节性变态反应
has_MedDRA_id: 10048908

hyponatremia AE
type: Class
subclass of: blood sodium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood sodium decreased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood sodium abnormal AE with an abnormally decreased sodium concentration in the blood
definition editor: YH, MW
alternative term: hyponatraemia AE
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/hyponatremia/basics/definition/con-20031445
has_MedDRA_id: 10021036
has_MedDRA_id: 10021038
see also: CTCAE: E12339
see also: NCIt: C37976

skin redness AE
type: Class
subclass of: erythema AE
definition: Skin redness AE is an erythema AE that is abnormal redness of the skin, often signaling a pathological condition, such as inflammation, infection, or sunburn.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthline.com/health/skin-redness
Chinese translation: 皮肤发红

angina AE
type: Class
subclass of: chest pain AE
subclass of: Restriction
  on property: is evidence of
  some values from: prinzmetal angina AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000948
definition: a chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood.
definition editor: DJ, SS, YH
alternative term: chest pain - cardiac AE
alternative term: tight chest AE
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723
has_MedDRA_id: 10002383
has_MedDRA_id: 10008481
see also: CTCAE: E10110
see also: HPO: HP_0001681
see also: NCIt: C51221
see also: SIDER: C0002962

aggravating angina AE
type: Class
subclass of: angina AE
subclass of: Restriction
  on property: is evidence of
  some values from: prinzmetal angina AE
definition: an angina AE that is aggravating.
definition editor: JX, YH

severe hypotension caused angina symptom aggravating AE
type: Class
subclass of: aggravating angina AE
subclass of: Restriction
  on property: is evidence of
  some values from: prinzmetal angina AE
definition: an aggravating angina AE that is caused by severe hypotension
definition editor: JX, YH
Chinese translation: 严重低血压导致心绞痛症状加重现象

blink reflex abnormal AE
type: Class
subclass of: eye AE
definition: an eye AE that shows abnormal involuntary blinking of the eyelids
definition editor: JX, LW, YH
alternative term: corneal reflex abnormal AE
definition source: URL: https://en.wikipedia.org/wiki/Corneal_reflex
Chinese translation: 睑闭反射反常
has_MedDRA_id: 10058960

dazzling AE
type: Class
subclass of: eye AE
definition: Dazzling AE is a eye disorder AE that has an outcome of the consequence of illumination too intense for adaptation by the eye. In contrast to glare, dazzling is alleviated by appropriate tinted glasses.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/dazzling
Chinese translation: 目眩

ventricular rhythm AE
type: Class
subclass of: arrhythmia AE
definition: Ventricular rhythm AE is an arrhythmia AE that shows the electrocardiographic finding of an ectopic ventricular rhythm with three or more consecutive ventricular premature beats with a rate less than 100 beats per minute.
definition editor: JX, LW, YH
Chinese translation: 室性心律
has_MedDRA_id: 10047297

extrapyramidal signs AE
type: Class
subclass of: nervous system AE
definition: Extrapyramidal signs AE is a nervous system AE that shows defects in basal ganglia function. It characterized by changes in muscle tone, poverty of voluntary movements (akinesia), or abnormal involuntary movements (dyskinesia).
definition editor: JX, LW, YH
Chinese translation: 锥体外体征

hearing disorder AE
type: Class
subclass of: ear AE
definition: Hearing disorder AE is an ear disorder that shows impairment of the sense of hearing.
definition editor: JX, LW, YH
Chinese translation: 听觉障碍
has_MedDRA_id: 10019243

yellow urine AE
type: Class
subclass of: urine abnormality AE
definition: Yellow urine AE is a urine abnormality AE that may be due to excretion of picric acid, dinitrophenol, phenacetin or chrysarobin or in alkaline pH, to increased secretion of anthocyanin, or associated with ingestion of beets or blackberries. Pure yellow urine is associated with increased acriflavine and has a green fluorescence; yellow-orange urine may be highly concentrated or contain increased bilirubin and biliverdin.
definition editor: JX, LW, YH
Chinese translation: 尿液呈黄色

epidermal necrosis AE
type: Class
subclass of: necrosis AE
definition: Epidermal necrosis AE is a necrosis AE that shows widespread keratinocyte cell death via apoptosis results in the tissue damage.
definition editor: JX, LW, YH
Chinese translation: 表皮坏死
has_MedDRA_id: 10059284

arthromeningitis AE
type: Class
subclass of: inflammation AE
definition: Arthromeningitis AE is an inflammation AE that shows inflammation of a synovial membrane, usually painful, particularly on motion, and characterized by fluctuating swelling, due to effusion in a synovial sac.
definition editor: JX, LW, YH
Chinese translation: 滑膜炎

pulmonary tuberculosis AE
type: Class
subclass of: lung AE
definition: Pulmonary tuberculosis AE is a lung disorder AE that is a contagious bacterial infection that involves the lungs. It may spread to other organs.
definition editor: JX, LW, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000077.htm
has_MedDRA_id: 10037440

coronary heart disease AE
type: Class
subclass of: cardiovascular AE
definition: Coronary heart disease AE is a cardiovascular disorder AE that is a disease in which a waxy substance called plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle.
definition editor: JX, LW, YH
definition source: WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/cad/
Chinese translation: 冠心病
has_MedDRA_id: 10068617

increased defecation frequency AE
type: Class
subclass of: abnormal stool AE
definition: Increased defecation frequency AE is a abnormal stool AE that shows defecation number increased.
definition editor: JX, LW, YH
Chinese translation: 大便次数增加

symptomatic hypotension AE
type: Class
subclass of: hypotension AE
definition: Symptomatic hypotension AE is a hypotension AE that shows blood pressure that less than 90/60 mm Hg with dizziness, vertigo etc.
definition editor: JX, LW, YH
Chinese translation: 症状性低血压

non-specific gastrointestinal dysfunction AE
type: Class
subclass of: gastrointestinal disorder AE
definition: Non-specific gastrointestinal dysfunction AE is a gastrointestinal disorder AE that shows non-specific gastrointestinal dysfunction.
definition editor: JX, LW, YH
alternative term: 非特异性胃肠功能紊乱

abnormal sclerotin AE
type: Class
subclass of: bone AE
definition: Abnormal sclerotin AE is a bone disorder AE that shows abnormal sclerotin.
definition editor: JX, LW, YH
Chinese translation: 骨质异常

fast and weak heart beat AE
type: Class
subclass of: cardiac disorder AE
definition: Fast and weak heart beat AE is a cardiac disorder AE that shows fast and weak heart beat.
definition editor: JX, LW, YH
Chinese translation: 心跳快而弱

pain over the liver AE
type: Class
subclass of: pain AE
definition: Pain over the liver AE is a pain AE that shows pain over the liver.
definition editor: JX, LW, YH
Chinese translation: 肝区痛

increased biliary calculus AE
type: Class
subclass of: hepatobiliary or pancreatic AE
definition: Increased biliary calculus AE is a liver, biliary, and pancreatic AE that shows increased biliary calculus.
definition editor: JX, LW, YH
Chinese translation: 胆石增加

muscle function disorder AE
type: Class
subclass of: muscle AE
definition: Muscle function disorder AE is a muscle AE that shows muscle function disorder.
definition editor: JX, LW, YH
Chinese translation: 肌肉功能失调

accidental fall AE
type: Class
subclass of: fall AE
definition: Accidental injury AE is a fall AE that shows accidental falls.
definition editor: JX, LW, YH
Chinese translation: 意外跌倒

accidental injury AE
type: Class
subclass of: injury AE
definition: Accidental injury AE is an injury AE that shows accidedntal injury.
definition editor: JX, LW, YH
Chinese translation: 意外损伤
has_MedDRA_id: 10000380

abnormal ejaculation AE
type: Class
subclass of: male reproductive system AE
definition: Abnormal ejaculation AE is a male reproductive system AE that shows abnormal ejaculation.
definition editor: JX, LW, YH
Chinese translation: 异常射精
has_MedDRA_id: 10000128

distention of head AE
type: Class
subclass of: cardiovascular AE
definition: Distention of head AE is a cardiovascular AE that shows distention of head.
definition editor: JX, LW, YH
Chinese translation: 头胀

water-sodium retention AE
type: Class
subclass of: abnormal fluid regulation AE
definition: Water-sodium retention AE is an abnormal fluid regulation AE that shows water-sodium retention.
definition editor: JX, LW, YH
definition source: WEB: http://www.livestrong.com/article/485782-sodium-retention-weight-gain/
Chinese translation: 水钠潴留

dizziness when standing up AE
type: Class
subclass of: dizziness AE
definition: Dizziness when standing up AE is a dizziness AE that shows dizziness when standing up.
definition editor: JX, LW, YH
Chinese translation: 站起时头晕

change of gustation AE
type: Class
subclass of: gustatory system AE
definition: Change of gustation AE is a gustatory system AE that shows the change of gustation.
definition editor: JX, LW, YH
Chinese translation: 味觉改变

vascular stimulation of pain AE
type: Class
subclass of: pain AE
definition: Vascular stimulation of pain AE is a pain AE that shows pain which due to vascular stimulation.
definition editor: JX, LW, YH
Chinese translation: 血管刺激性疼痛

vascular pain AE
type: Class
subclass of: pain AE
definition: Vascular pain AE is a pain AE that shows vascular pain.
definition editor: JX, LW, YH
Chinese translation: 血管疼痛

heaviness sense of arm AE
type: Class
subclass of: sensation of heaviness AE
definition: Heaviness sense of arm AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the arm.
definition editor: JX, LW, YH
Chinese translation: 手臂沉重感

breast swelling AE
type: Class
subclass of: edema AE
definition: Breast swelling AE is an edema AE that is common for almost all women in the second half of their menstrual cycle. It in the premenstrual portion of the cycle can be mild to severe.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthgrades.com/symptoms/breast-swelling
Chinese translation: 乳房肿胀
has_MedDRA_id: 10006312

gastrointestinal cramp AE
type: Class
subclass of: muscle spasm AE
definition: Gastrointestinal cramp AE is a muscle spasm AE that shows abnormal contractions of the gastrointestinal muscles.
definition editor: JX, LW, YH
Chinese translation: 肠胃痉挛
has_MedDRA_id: 10049136

heart discomfort AE
type: Class
subclass of: discomfort AE
definition: Heart discomfort AE is a discomfort AE that shows an uncomfortable feeling in the heart.
definition editor: JX, LW, YH
Chinese translation: 心脏不适

angiectopia of skin AE
type: Class
subclass of: vascular disorder AE
definition: Angiectopia of skin AE a vascular disorder AE that shows abnormal position or course of a vessel in the skin.
definition editor: JX, LW, YH
Chinese translation: 皮肤血管异位

joint discomfort AE
type: Class
subclass of: discomfort AE
definition: Joint discomfort AE is a discomfort AE that shows an uncomfortable feeling in the joint.
definition editor: JX, LW, YH
Chinese translation: 关节不适

eye discomfort AE
type: Class
subclass of: discomfort AE
definition: Eye discomfort AE is a discomfort AE that shows an uncomfortable feeling in the eye.
definition editor: JX, LW, YH
Chinese translation: 眼部不适

instability of gait AE
type: Class
subclass of: abnormal gait AE
definition: Instability of gait AE is a abnormal gait AE that shows instability of gait.
definition editor: JX, LW, YH
Chinese translation: 步态不稳

pemphigoid injury AE
type: Class
subclass of: injury AE
definition: Pemphigoid injury AE is an injury AE that shows a skin disorder where one has large blisters on the skin.
definition editor: JX, LW, YH
Chinese translation: 类天疱疮样损伤

pulse frequency change AE
type: Class
subclass of: cardiovascular AE
definition: Pulse frequency change AE is a cardiovascular AE that shows dpulse frequency change.
definition editor: JX, LW, YH
alternative term: pulse abnormal AE
Chinese translation: 脉搏频率变化

inhibition of myocardial contraction force AE
type: Class
subclass of: cardiac disorder AE
definition: Inhibition of myocardial contraction force AE is a cardiac disorder AE that shows inhibition of myocardial contraction force.
definition editor: JX, LW, YH
Chinese translation: 抑制心肌收缩力

decreased of atrial conduction velocity AE
type: Class
subclass of: conduction system disorder AE
definition: Decreased of atrial conduction velocity AE is a conduction system disorder AE that shows decreased of atrial conduction velocity.
definition editor: JX, LW, YH
Chinese translation: 心房传导速度减慢

spasm of lower limbs AE
type: Class
subclass of: muscle spasm AE
definition: Spasm of lower limbs AE is a muscle spasm AE that shows tightening and spasms of the muscles in the legs.
definition editor: JX, LW, YH
Chinese translation: 下肢痉挛

electrocardiogram prolonged PR interval AE
type: Class
subclass of: electrocardiogram result abnormal AE
definition: Electrocardiogram prolonged PR interval AE is an electrocardiogram result abnormal AE that shows a prolonged time between the onset of atrial depolarization (P wave) to the beginning of ventricular depolarization (QRS complex).
definition editor: JX, LW, YH
Chinese translation: 心电图出现PR间期延长

qrs wave broadening AE
type: Class
subclass of: electrocardiogram qrs complex abnormal AE
definition: Qrs wave broadening AE is a electrocardiogram qrs complex abnormal AE that shows broadening qrs complex in the electrocardiogram.
definition editor: JX, LW, YH
Chinese translation: QRS波增宽

edema of lower limbs AE
type: Class
subclass of: edema AE
definition: Edema of lower limbs AE is an edema AE that shows enlargement of the leg, due to the accumulation of fluids.
definition editor: JX, LW, YH
Chinese translation: 下肢浮肿

accelerated pulse AE
type: Class
subclass of: cardiovascular AE
definition: Accelerated pulse AE is a cardiovascular AE that shows increased of the number of pulsations per minute palpable in an artery.
definition editor: JX, LW, YH
Chinese translation: 脉搏加快

bitter taste of mouth AE
type: Class
subclass of: digestive system AE
definition: Bitter taste of mouth AE is a digestive system AE that is not from a bitter substance is a distorted sense of taste. A persistent bad taste in the mouth, whether bitter, metallic or foul, is called dysgeusia.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthgrades.com/symptoms/bitter-taste-in-mouth
Chinese translation: 口苦

skin irritant reaction AE
type: Class
subclass of: skin AE
definition: Skin irritant reaction AE is a skin AE that shows rash, inflammation, swelling, scaling, or abnormal tissue which growth in the affected area.
definition editor: JX, LW, YH
Chinese translation: 皮肤刺激反应

vitreous suspended substance AE
type: Class
subclass of: eye AE
definition: Vitreous suspended substance AE is an eye AE shows vitreous suspended substance in the eyes.
definition editor: JX, LW, YH
Chinese translation: 玻璃体悬浮物

dreaminess AE
type: Class
subclass of: sleep disorder AE
definition: Dreaminess AE is a sleep disorder AE that shows dreaminess in the sleeping.
definition editor: JX, LW, YH
Chinese translation: 多梦

abdominal spasm AE
type: Class
subclass of: muscle spasm AE
definition: Abdominal spasm AE is a muscle spasm AE that is typically a feeling of cramping in the abdomen caused by a rigid expansion of muscles. It can vary from mild discomfort to moderate or severe pain.
definition editor: JX, LW, YH
definition source: WEB: http://www.wisegeekhealth.com/what-are-abdominal-spasms.htm
Chinese translation: 腹部痉挛
has_MedDRA_id: 10051889

coronary contraction AE
type: Class
subclass of: coronary artery disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001621
definition: Coronary contraction AE is a coronary artery disorder AE that shows coronary contraction.
definition editor: JX, LW, YH
Chinese translation: 冠状动脉收缩

lower extremity edema caused by blood vessels AE
type: Class
subclass of: edema AE
definition: Lower extremity edema caused by blood vessels AE is an edema AE that shows excess fluid accumalated in the leg dut to blood vessels.
definition editor: JX, LW, YH
Chinese translation: 因血管扩张引起的下肢水肿

asthenia of lower limbs AE
type: Class
subclass of: asthenia AE
definition: Asthenia of lower limbs AE is a asthenia AE that occurs in the lower limbs. It is a condition typified by a weakness of voluntary movement.
definition editor: JX, LW, YH
Chinese translation: 下肢无力

small bronchial lumen occlusion AE
type: Class
subclass of: lung AE
definition: Small bronchial lumen occlusion AE is a lung disorder AE that shows small bronchial lumen occlusion.
definition editor: JX, LW, YH
Chinese translation: 小支气管腔闭塞

prolonged orthostatic hypotension AE
type: Class
subclass of: orthostatic hypotension AE
definition: Prolonged orthostatic hypotension AE is a orthostatic hypotension AE that shows prolonged orthostatic hypotension.
definition editor: JX, LW, YH
Chinese translation: 延长体位性低血压时间

cross allergic reaction AE
type: Class
subclass of: allergy AE
definition: an allergy AE that shows produce cross or incomplete cross allergic reaction to similar medicinal chemistry structure.
definition editor: JX, LW, YH
Chinese translation: 交叉过敏反应

deep venous thrombophlebitis AE
type: Class
subclass of: thrombophlebitis AE
definition: Deep venous thrombophlebitis AE is a thrombophlebitis AE that is causes by a blood clot blocking in the deep vein.
definition editor: JX, LW, YH
Chinese translation: 深静脉血栓静脉炎

change of hematology AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: Change of hematology AE is a hematology investigation result abnormal AE that shows the change of hematology.
definition editor: JX, LW, YH
Chinese translation: 血液学改变

cardiac depression AE
type: Class
subclass of: cardiac disorder AE
definition: Cardiac depression AE is a cardiac disorder AE that shows cardiac depression.
definition editor: JX, LW, YH
Chinese translation: 抑制心脏

side limb numbness AE
type: Class
subclass of: numbness AE
definition: Side limb numbness AE is a numbness AE that shows reduced or loss of sensation on the skin of an arm and leg on the same side of the body.
definition editor: JX, LW, YH
Chinese translation: 侧肢的麻木感

numbness of tongue AE
type: Class
subclass of: numbness AE
definition: Numbness of tongue AE is a numbness AE that shows abnormal feeling or loss of sensation in the tongue.
definition editor: JX, LW, YH
Chinese translation: 舌部麻木

numbness of the limbs AE
type: Class
subclass of: numbness AE
definition: Numbness of the limbs AE is a numbness AE that shows reduced or loss of sensation on the skin of the arm and leg.
definition editor: JX, LW, YH
Chinese translation: 肢体麻木

lip numbness AE
type: Class
subclass of: numbness AE
definition: Lip numbness AE is a numbness AE that shows abnormal feeling in the lips, including numbness and tingling.
definition editor: JX, LW, YH
Chinese translation: 嘴唇发麻

reflex Increased pulse rate AE
type: Class
subclass of: cardiovascular AE
definition: Reflex Increased pulse rate AE is a cardiovascular AE that shows increased pulse rate.
definition editor: JX, LW, YH
Chinese translation: 反射性脉率增加

irritation of the digestive tract AE
type: Class
subclass of: digestive system AE
definition: Irritation of the digestive tract AE is a digestive system AE that shows irritation of the digestive tract.
definition editor: JX, LW, YH
Chinese translation: 消化道刺激

unconscious chorea AE
type: Class
subclass of: chorea AE
definition: Unconscious chorea AE is a chorea AE that is characterized by brief, non-repetitive irregular muscle contractions.
definition editor: JX, LW, YH
Chinese translation: 不自觉舞蹈症

phlebectasia of limbs AE
type: Class
subclass of: vasodilatation AE
definition: Phlebectasia of limbs AE is a vasodilatation AE that shows dilation of the veins in the extremity.
definition editor: JX, LW, YH
Chinese translation: 肢端静脉扩张

heart beat skip AE
type: Class
subclass of: irregular heartbeat AE
definition: Heart beat skip AE is a irregular heartbeat AE which is sometimes called as either heart palpitation, or premature atrial or ventricular contraction are very common occurrences. They may or may not be accompanied by heart conditions or heart problems.
definition editor: JX, LW, YH
definition source: WEB: http://ehealthwall.com/heart-skips-a-beat-causes-symptoms-treatment/
Chinese translation: 漏跳

fatal liver cell necrosis AE
type: Class
subclass of: hepatic necrosis AE
definition: Fatal liver cell necrosis AE is a hepatic necrosis AE that has an outcome of fatal liver cell necrosis.
definition editor: JX, LW, YH
Chinese translation: 致命性肝细胞坏死

warm and hot feeling in the neck AE
type: Class
subclass of: skin warm AE
definition: Warm and hot feeling in the neck AE is a skini warm AE that shows warm and hot feeling in the neck.
definition editor: JX, LW, YH
Chinese translation: 颈感觉温热

facial warm feeling AE
type: Class
subclass of: skin warm AE
definition: Facial warm feeling AE is a skin warm AE that shows a warm feeling in the face.
definition editor: JX, LW, YH
Chinese translation: 面部感觉温热

increased peripheral vascular resistance AE
type: Class
subclass of: vascular disorder AE
definition: Increased peripheral vascular resistance AE is a vascular disorder AE that shows increased peripheral vascular resistance, the degree to which the blood vessels impede the flow of blood. High resistance causes an increase in blood pressure, which increases the workload of the heart.
definition editor: JX, LW, YH
Chinese translation: 外周血管阻力升高

venous ischemia AE
type: Class
subclass of: ischemia AE
definition: Venous ischemia AE is an ischaemia AE that shows in insufficient blood supply in the vein.
definition editor: JX, LW, YH
Chinese translation: 静脉供血不足

increased blood creatine AE
type: Class
subclass of: metabolic and nutritional investigation result abnormal AE
definition: Increased blood creatine AE is a metabolic and nutritional investigation result abnormal AE that shows an increased creatine level in blood.
definition editor: JX, LW, YH
Chinese translation: 血肌酸增加

increased nonprotein nitrogen AE
type: Class
subclass of: investigation result abnormal AE
definition: Increased nonprotein nitrogen AE is an investigation result abnormal AE that shows increased nonprotein nitrogen, the nitrogenous constituents of the blood exclusive of the protein bodies, consisting of the nitrogen of urea, uric acid, creatine, creatinine, amino acids, polypeptides, and an undetermined part known as rest nitrogen.
definition editor: JX, LW, YH
Chinese translation: 非蛋白氮增加

soft feces AE
type: Class
subclass of: abnormal stool AE
definition: Soft feces AE is a abnormal stool AE that shows soft and shapeless of the feces.
definition editor: JX, LW, YH
Chinese translation: 软便

increased hepatic function AE
type: Class
subclass of: hepatic function abnormal AE
definition: Increased hepatic function AE is a hepatic function abnormal AE that shows the values of liver function tests (LFTs) high than the normal.
definition editor: JX, LW, YH
definition source: WEB: http://www.webmd.com/a-to-z-guides/liver-function-test-lft
Chinese translation: 肝功能升高

knee pain AE
type: Class
subclass of: pain AE
definition: Knee pain AE is a pain AE that shows discomfort in the structures of both knees. Keen pain may be due to injury, inflammation or infection.
definition editor: JX, LW, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/knee-pain/basics/definition/CON-20029534
Chinese translation: 膝痛
has_MedDRA_id: 10023477

loss of libido AE
type: Class
subclass of: libido disorder AE
definition: Loss of libido AE is a libido disorder AE that shows loss of the desire for sexual interaction.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder
Chinese translation: 性欲丧失
has_MedDRA_id: 10024870

over sedation AE
type: Class
subclass of: behavioral and neurological AE
definition: Over sedation AE is a behavior and neurological AE that shows the over reduction of irritability or agitation.
definition editor: JX, LW, YH
Chinese translation: 过度镇静

finger tremor AE
type: Class
subclass of: tremor AE
definition: Finger tremor AE is a tremor AE that shows involuntary muscle contraction and relaxation in the finger.
definition editor: JX, LW, YH
Chinese translation: 手指强硬颤动

leg cramp AE
type: Class
subclass of: muscle cramp AE
definition: Leg cramp AE is a muscle cramp AE that shows tightening, or spasms, of the muscles in the legs.
definition editor: JX, LW, YH
Chinese translation: 腿部痉挛

insomnia AE
type: Class
subclass of: sleep disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sleep disorder AE in which there is an inability to fall asleep or to stay asleep as long as desired.
definition editor: YH, MW
definition source: WEB: https://en.wikipedia.org/wiki/Insomnia
has_MedDRA_id: 10022437
comment: Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease.
see also: CTCAE: E12925
see also: HPO: HP_0002360
see also: SIDER: C0917801

terminal insomnia AE
type: Class
subclass of: insomnia AE
definition: Terminal insomnia AE is a insomnia AE that is a medical condition affecting sleep patterns. Typically, people who suffer from terminal insomnia wake up after only four to five hours of sleep. For those afflicted, getting back to sleep can be difficult, resulting in fatigue, irritability, and lack of concentration.
definition editor: JX, LW, YH
alternative term: matutinal insomnia AE
definition source: WEB: http://www.wisegeek.com/what-is-terminal-insomnia.htm
definition source: 早醒
has_MedDRA_id: 10068932

bone marrow granuloma AE
type: Class
subclass of: bone marrow disorder AE
definition: Bone marrow granuloma AE is a bone marrow disorder AE that shows an organized collection of macrophages in the bone marrow.
definition editor: JX, LW, YH
Chinese translation: 骨髓肉芽肿
has_MedDRA_id: 10066816

cholestatic liver injury AE
type: Class
subclass of: liver damage AE
definition: Cholestatic liver injury AE is a liver damage AE that shows buildup of bile acids in hepatocytes, then causes hepatocellular injury.
definition editor: JX, LW ,YH
Chinese translation: 胆汁郁积性肝损伤
has_MedDRA_id: 10067969

distant heart sounds AE
type: Class
subclass of: cardiac disorder AE
definition: Distant heart sounds AE is a cardiac disorder AE that shows distant heart sounds.
definition editor: JX, LW, YH
Chinese translation: 心音遥远

pink skin AE
type: Class
subclass of: skin AE
definition: Pink skin AE is a skin AE that shows pink skin.
definition editor: JX, LW, YH
Chinese translation: 皮肤粉红

acute laryngeal edema AE
type: Class
subclass of: edema AE
definition: Acute laryngeal edema AE is an edema AE that shows acute laryngeal edema, abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions.
definition editor: JX, LW, YH
Chinese translation: 急性喉头水肿
has_MedDRA_id: 10066705

hypoplastic bone marrow AE
type: Class
subclass of: bone marrow disorder AE
definition: Hypoplastic bone marrow AE is a bone marrow disorder AE that shows insufficient blood stem cells in the marrow.
definition editor: JX, LW, YH
Chinese translation: 骨髓发育不全

bleeding and coagulation disorders AE
type: Class
subclass of: hematopoietic system AE
definition: Bleeding and coagulation disorders AE is a hematopoietic system AE that shows bleeding and coagulation disorders.
definition editor: JX, LW, YH
Chinese translation: 出凝血功能障碍

polymorphic ventricular tachycardia AE
type: Class
subclass of: ventricular tachycardia AE
definition: Polymorphic ventricular tachycardia AE is a ventricular tachycardia AE that is an abnormally fast heart rhythm starting in the ventricles, the lower chambers of the heart.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthguideinfo.com/arrhythmias-heart-palpitations/p110132/
Chinese translation: 多行性室性心动过速
has_MedDRA_id: 10036095

monomorphic ventricular tachycardia AE
type: Class
subclass of: ventricular tachycardia AE
definition: Monomorphic ventricular tachycardia AE is a ventricular tachycardia AE that is a type of tachycardia which has a uniform beat-to-beat QRS morphology.
definition editor: JX, LW, YH
Chinese translation: 单行性室性心动过速
has_MedDRA_id: 10058185

respiratory tract symptoms AE
type: Class
subclass of: respiratory system AE
definition: Respiratory tract symptoms AE is a respiratory system AE that is a series of discomforts which occurs in respiratory tract.
definition editor: JX, LW, YH
Chinese translation: 呼吸道症状

clammy skin AE
type: Class
subclass of: skin AE
definition: Clammy skin AE is a skin AE that occurs when the skin turns cooler than normal and is moist, despite a cooler surface temperature. Clammy skin is often pale.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthgrades.com/symptoms/clammy-skin
Chinese translation: 皮肤湿冷

abnormal visual accommodation AE
type: Class
subclass of: abnormal vision AE
definition: Abnormal visual accommodation AE is an abnormal vision AE that shows abnormal visual accommodation. Accommodation is the process by which the vertebrate eye changes optical power to maintain a clear image or focus on an object as its distance varies.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Accommodation_%28eye%29
Chinese translation: 视调节异常

skin allergy AE
type: Class
subclass of: allergy AE
definition: an allergy AE that shows swelling and irritation of the skin, caused by an allergy to a substance in the environment.
definition editor: JX, LW, YH
Chinese translation: 皮肤过敏

heaviness of the head AE
type: Class
subclass of: sensation of heaviness AE
definition: Heaviness of the head AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the head.
definition editor: JX, LW, YH
Chinese translation: 头重感
has_MedDRA_id: 10049121

rheumatoid factor positive AE
type: Class
subclass of: immunology and allergy investigation result abnormal AE
definition: Rheumatoid factor positive AE is an immunology and allergy investigation result abnormal AE that shows positive of the rheumatoid factor. Rheumatoid factor is a blood test that measures the amount of the RF antibody in the blood.
definition editor: JX, LW, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003548.htm
Chinese translation: 类风湿因子阳性
has_MedDRA_id: 10039080

retinal detachment AE
type: Class
subclass of: eye AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: Retinal detachment AE is an eye AE that is a separation of the retina from its attachments to the underlying tissue within the eye.
definition editor: JX, LW, YH
definition source: WEB: http://www.medicinenet.com/retinal_detachment/article.htm
Chinese translation: 视网膜脱离
has_MedDRA_id: 10038848
see also: CTCAE: E10420
see also: NCIT: C26874
see also: NCIt: C26874

arm pain AE
type: Class
subclass of: pain AE
definition: Arm pain AE is a pain AE that shows discomfort in the structures of the arm. It can be caused by a wide variety of problems, ranging from joint injuries to compressed nerves.
definition editor: JX, LW, YH
definition source: WEB: http://www.mayoclinic.org/symptoms/arm-pain/basics/definition/SYM-20050870
Chinese translation: 手臂疼痛

peripheric paresthesia AE
type: Class
subclass of: paresthesia AE
definition: Peripheric paresthesia AE is a paresthesia AE that shows paresthesia in the peripheric area.
definition editor: JX, LW, YH
Chinese translation: 外周感觉异常

edema of glottis AE
type: Class
subclass of: edema AE
definition: Edema of glottis AE is an edema AE that is a swelling caused by fluid accumulation in the soft tissues of the larynx. The condition, usually inflammatory, may result from an infection, injury, allergy, or inhalation of toxic substances.
definition editor: JX, LW, YH
Chinese translation: 声门肿胀

prolonged qrs complex AE
type: Class
subclass of: electrocardiogram qrs complex abnormal AE
definition: Prolonged qrs complex AE is a electrocardiogram qrs complex abnormal AE that shows qrs complex prolonged. The QRS complex is a name for the combination of three of the graphical deflections seen on a typical electrocardiogram.
definition editor: JX, LW, YH
Chinese translation: QRS时间延长

prolonged bleeding time AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: Prolonged bleeding time AE is a hematology investigation result abnormal AE that shows prolonged time for small blood vessels in the skin close to stop from bleeding.
definition editor: JX, LW, YH
Chinese translation: 出血时间延长

acute generalized exanthematous pustulosis AE
type: Class
subclass of: skin AE
definition: Acute generalized exanthematous pustulosis AE is a skin AE that is a not uncommon cutaneous reaction pattern that in 90% of cases is related to medication administration, characterized by a sudden eruption that appears on average five days after the medication is started.
definition editor: JX, LW, YH
alternative term: pustular drug eruption AE
alternative term: toxic pustuloderma AE
definition source: WEB: http://en.wikipedia.org/wiki/Acute_generalized_exanthematous_pustulosis
Chinese translation: 急性全身性浓疱病
has_MedDRA_id: 10062372

upper and lower limbs flare AE
type: Class
subclass of: edema AE
definition: Upper and lower limbs flare AE is an edema AE that shows edema in the upper and lower limbs, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
definition editor: JX, LW, YH
Chinese translation: 上下肢红肿

abnormal blood sugar with empty stomach AE
type: Class
subclass of: blood glucose level abnormal AE
definition: Abnormal blood sugar with empty stomach AE is a blood glucose level abnormal AE that shows abnormal blood glucose level with empty stomach.
definition editor: JX, LW, YH
Chinese translation: 空腹时血糖异常

increased blood sugar with empty stomach AE
type: Class
subclass of: blood glucose level decreased AE
definition: Increased blood sugar with empty stomach AE is blood glucose level decreased AE that shows an increased glucose level in blood with empty stomach.
definition editor: JX, LW, YH
Chinese translation: 空腹时血糖升高

hydrochloric acid in gastric juice secretion increased AE
type: Class
subclass of: gastric disorder AE
definition: Hydrochloric acid in gastric juice secretion increased AE is a gastric disorder AE that shows increased gastric acid.
definition editor: JX, LW, YH
Chinese translation: 胃酸分泌增多

torsades de pointes AE
type: Class
subclass of: ventricular tachycardia AE
definition: Torsades de pointes AE is a ventricular tachycardia AE that is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Torsades_de_pointes
Chinese translation: 扭转性室速
has_MedDRA_id: 10044067

proximal myasthenia AE
type: Class
subclass of: myasthenia AE
definition: Proximal myasthenia AE is a myasthenia AE that shows proximal myasthenia. Myasthenia represents myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatigability.
definition editor: JX, LW, YH
Chinese translation: 近端肌无力

dilated skin vessels AE
type: Class
subclass of: vasodilatation AE
definition: Dilated skin vessels AE is a vasodilatation AE that shows vasodilatation in the skin, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins.
definition editor: JX, LW, YH
Chinese translation: 皮肤血管扩张

numbness of oral mucosa AE
type: Class
subclass of: numbness AE
definition: Numbness of oral mucosa AE is a numbness AE that shows an abnormal feeling or loss of sensation in the oral mucosa.
definition editor: JX, LW, YH
Chinese translation: 口腔黏膜发麻

orthostatic dizziness AE
type: Class
subclass of: dizziness AE
definition: Orthostatic dizziness AE is a dizziness AE that shows dizziness provocation by sudden postural change.
definition editor: JX, LW, YH
Chinese translation: 体位性头晕
has_MedDRA_id: 10031125

acid reflux AE
type: Class
subclass of: digestive system AE
definition: Acid reflux AE is a digestive system AE that shows the acid and pepsin secreted in the stomach back up in to the esophagus.
definition editor: JX, LW, YH
Chinese translation: 反酸
has_MedDRA_id: 10066872

jugular phlebectasia AE
type: Class
subclass of: vasodilatation AE
definition: Jugular phlebectasia AE is a vasodilatation AE that is an isolated saccular or fusiform dilation of a vein without tortuosity.
definition editor: JX, LW, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708235/
Chinese translation: 颈静脉扩张

laryngeal edema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Laryngeal edema AE is an edema AE that shows abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions.
definition editor: JX, LW, YH, MW
alternative term: laryngeal oedema AE
Chinese translation: 喉肿胀
has_MedDRA_id: 10023838

flatus AE
type: Class
subclass of: digestive system AE
definition: Flatus AE is a digestive system AE that shows gas or air expelled through the anus.
definition editor: JX, LW, YH
Chinese translation: 排气
has_MedDRA_id: 10016769

continuous polymorphic ventricular tachycardia AE
type: Class
subclass of: polymorphic ventricular tachycardia AE
definition: Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is constantly.
definition editor: JX, LW, YH
Chinese translation: 连续性多形性室性心动过速

intermittent polymorphic ventricular tachycardia AE
type: Class
subclass of: polymorphic ventricular tachycardia AE
definition: Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is intermittent.
definition editor: JX, LW, YH
Chinese translation: 间歇性多形性室性心动过速

aggravated ulcer AE
type: Class
subclass of: ulcer AE
definition: Aggravated ulcer AE is a ulcer AE that shows aggravated ulcer.
definition editor: JX, LW, YH
Chinese translation: 溃疡加重

heart failure increased AE
type: Class
subclass of: cardiac failure AE
definition: Heart failure increased AE is a cardiovascular disorder AE that shows aggravated heart failure.
definition editor: JX, LW, YH
Chinese translation: 心脏衰竭加重

aggravated angina symptoms AE
type: Class
subclass of: angina pectoris AE
definition: Aggravated angina symptoms AE is a angina pectoris AE that shows aggravated angina symptoms.
definition editor: JX, LW, YH
Chinese translation: 心绞痛症状加剧

aggravated renal injury AE
type: Class
subclass of: renal impairment AE
definition: Aggravated renal injury AE is a renal impairment AE that shows aggravated renal injury.
definition editor: JX, LW, YH
Chinese translation: 肾损害加剧

aggravated fatigue AE
type: Class
subclass of: fatigue AE
definition: Aggravated fatigue AE is a fatigue AE that shows aggravated fatigue.
definition editor: JX, LW, YH
Chinese translation: 脱力感加重

persistent nausea AE
type: Class
subclass of: nausea AE
definition: Persistent nausea AE is a nausea AE that shows constant nausea. Nausea is considered "persistent" if it continues for more than 2 days, or keeps recurring even after treatment.
definition editor: JX, LW, YH
definition source: WEB: http://www.all4naturalhealth.com/persistent-nausea.html
Chinese translation: 持续恶心

aggravated Raynaud's syndrome AE
type: Class
subclass of: Raynaud's syndrome AE
definition: Aggravated Raynaud's syndrome AE is a Raynaud's syndrome AE that shows aggravated Raynaud's syndrome.
definition editor: JX, LW, YH
Chinese translation: Raynaud综合征加重

increased gastric acid secretion with high dose AE
type: Class
subclass of: gastric disorder AE
definition: Increased gastric acid secretion with high dose AE is a gastric disorder AE that shows increased gastric acid secretion with high dose.
definition editor: JX, LW, YH
Chinese translation: 高剂量时胃酸分泌增加

persistent vomiting AE
type: Class
subclass of: vomiting AE
definition: Persistent vomiting AE is a vomiting AE that occurs frequently throughout the day and is often triggered by even small meals.
definition editor: JX, LW, YH
definition source: WEB: http://www.healthhype.com/persistent-and-recurrent-vomiting-emesis-in-adults-and-children.html
Chinese translation: 持续呕吐
has_MedDRA_id: 10034716

hypoacusis AE
type: Class
subclass of: hearing disorder AE
definition: Hypoacusis AE is a hearing disorder AE that shows partial or complete loss of the ability to detect or understand sounds resulting from damage to the outer, middle, or inner ear structures. Causes include exposure to loud noise, ear infections, injuries to the ear, genetic, and congenital disorders.
definition editor: JX, LW, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hypoacusis
Chinese translation: 突发听力减退
has_MedDRA_id: 10048865

lip cyanosis AE
type: Class
subclass of: cyanosis AE
definition: Lip cyanosis AE is a cyanosis AE that is a condition in which the lips have a bluish discoloration due to a lack of oxygen in the tissues.
definition editor: JX, LW, YH
definition source: WEB: http://www.rightdiagnosis.com/sym/lip_cyanosis.htm
Chinese translation: 嘴唇发紫

nail cyanosis AE
type: Class
subclass of: cyanosis AE
definition: Nail cyanosis AE is a cyanosis AE that shows a dark bluish or purple nail resulting from deficient oxygenation of the blood.
definition editor: JX, LW, YH
Chinese translation: 指甲青紫

renal insufficiency AE
type: Class
subclass of: kidney AE
definition: Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia.
editor note: This term appears to be a synonym to the 'renal failure AE'.
definition editor: JX, LW, YH
alternative term: hepatic and renal function disorder AE
Chinese translation: 肾功能障碍
see also: UMLS ID: C0859242

hemolysis AE
type: Class
subclass of: hematopoietic system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition editor: JX, LW, YH
alternative term: Hemolysis AE is a hematopoietic system AE that is the rupturing of erythrocytes (red blood cells) and the release of their contents (cytoplasm) into surrounding fluid.
definition source: WEB: http://en.wikipedia.org/wiki/Hemolysis
Chinese translation: 溶血
has_MedDRA_id: 10019491
see also: CTCAE: E10037
see also: NCIt: C37965

lip angioedema AE
type: Class
subclass of: angioedema AE
definition: Lip angioedema AE is a angioedema AE that shows lip angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues.
definition editor: JX, LW, YH
Chinese translation: 唇血管神经性水肿

tongue angioedema AE
type: Class
subclass of: angioedema AE
definition: Tongue angioedema AE is a angioedema AE that shows tongue angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues.
definition editor: JX, LW, YH
Chinese translation: 舌血管神经性水肿

acousma AE
type: Class
subclass of: sensory capability AE
definition: Acousma AE is a sensory capability AE that shows a hallucinatory impression of strange sounds.
definition editor: JX, LW, YH
Chinese translation: 幻听

eye burning AE
type: Class
subclass of: eye AE
definition: Eye burning AE is a eye AE that shows a feeling of burning in the eye.
definition editor: JX, LW, YH
Chinese translation: 眼睛灼烧感

worsening renal function AE
type: Class
subclass of: kidney AE
definition: Worsening renal function AE is a kidney AE that shows worsening renal function.
definition editor: JX, LW, YH
Chinese translation: 肾功能恶化

mild change of hematology AE
type: Class
subclass of: change of hematology AE
definition: Mild change of hematology AE is a change of hematology AE that shows mild change of hematology.
definition editor: JX, LW, YH
Chinese translation: 轻度的血液学改变

moderate change of hematology AE
type: Class
subclass of: change of hematology AE
definition: Moderate change of hematology AE is a change of hematology AE that shows moderate change of hematology.
definition editor: JX, LW, YH
Chinese translation: 中度的血液学改变

severe lower blood pressure AE
type: Class
subclass of: hypotension AE
definition: Severe lower blood pressure AE is a hypotension AE that shows severe sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
alternative term: significantly decreased blood pressure AE
Chinese translation: 严重的血压降低

elevated blood transaminase reversibility AE
type: Class
subclass of: transaminase level increased AE
definition: Elevated blood transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly.
definition editor: JX, LW, YH
Chinese translation: 血氨基转移酶可逆性升高

mild gastrointestinal tract reaction AE
type: Class
subclass of: gastrointestinal disorder AE
definition: Mild gastrointestinal tract reaction AE is a gastrointestinal disorder AE that shows a mild gastrointestinal disorder.
definition editor: JX, LW, YH
Chinese translation: 轻度胃肠道反应

temporary abdominal distention AE
type: Class
subclass of: abdominal distension AE
definition: Temporary abdominal distention AE is a abdominal distension AE that shows a temporary sensation of elevated abdominal pressure and volume.
definition editor: JX, LW, YH
Chinese translation: 暂时性腹胀

transient nausea AE
type: Class
subclass of: nausea AE
definition: Transient nausea AE is a nausea AE that is a gastric discomfort associated with the inclination to vomit.
definition editor: JX, LW, YH
Chinese translation: 暂时性恶心

persistent tachycardia AE
type: Class
subclass of: tachycardia AE
definition: Persistent tachycardia AE is a tachycardia AE that is an increased heart rate that exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual). It's a constant process.
definition editor: JX, LW, YH
Chinese translation: 持续心动过速

mild headache AE
type: Class
subclass of: headache AE
definition: Mild headache AE is a headache AE that shows mild headache.
definition editor: JX, LW, YH
Chinese translation: 轻度头痛

transient hypoxemia AE
type: Class
subclass of: hypoxia AE
definition: Transient hypoxemia AE is a hypoxia AE that is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases.
definition editor: JX, LW, YH
Chinese translation: 瞬态低氧血症

transient neuroticism AE
type: Class
subclass of: neuroticism AE
definition: Transient neuroticism AE is a neuroticism AE that is a type of personality trait that contrasts adjustment or emotional stability with maladjustment. Experience of anxiety, anger, disgust, sadness, embarrassment, and a variety of other negative emotions.
definition editor: JX, LW, YH
Chinese translation: 瞬态神经质

constant irritability AE
type: Class
subclass of: irritability AE
definition: Constant irritability AE is a irritability AE that shows in the patient being easily annoyed/irritated constantly.
definition editor: JX, LW, YH
Chinese translation: 持续烦躁

abnormal atony AE
type: Class
subclass of: asthenia AE
definition: Abnormal atony AE is a asthenia AE that is a medical term denoting symptoms of physical weakness and loss of strength.
definition editor: JX, LW, YH
Chinese translation: 异常无力

secondary hypotension AE
type: Class
subclass of: hypotension AE
definition: Secondary hypotension AE is a hypotension AE that is a type of hypertension which by definition is caused by an identifiable underlying secondary cause.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Secondary_hypertension
Chinese translation: 继发性高血压

transient elevated serum transaminase AE
type: Class
subclass of: transaminase level increased AE
definition: Transient elevated serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase transiently.
definition editor: JX, LW, YH
Chinese translation: 瞬时血清转氨酶升高

transient elevated blood urea nitrogen AE
type: Class
subclass of: blood urea level increased AE
definition: Transient elevated blood urea nitrogen AE is a blood urea level increased AE that shows a transient increase in amount of urea in blood.
definition editor: JX, LW, YH
Chinese translation: 瞬时血尿素氮升高

apparent increased blood creatine phosphokinase AE
type: Class
subclass of: blood creatine phosphokinase level increased AE
definition: Apparent increased blood creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an apparent increased level of creatine phosphokinase or phosphocreatine kinase.
definition editor: JX, LW, YH
Chinese translation: 明显的血肌酸磷酸激酶增高

severe rhabdomyolysis AE
type: Class
subclass of: rhabdomyolysis AE
definition: Severe rhabdomyolysis AE is a rhabdomyolysis AE that shows in severe damaged skeletal muscle tissue breaks down rapidly.
definition editor: JX, LW, YH
Chinese translation: 严重的横纹肌溶解症

mild gastrointestinal bleeding AE
type: Class
subclass of: gastrointestinal hemorrhage AE
definition: Mild gastrointestinal bleeding AE is a gastrointestinal hemorrhage AE that shows mild gastrointestinal hemorrhage.
definition editor: JX, LW, YH
Chinese translation: 胃肠道轻微出血

occult gastrointestinal tract bleeding AE
type: Class
subclass of: gastrointestinal hemorrhage AE
definition: Occult gastrointestinal tract bleeding AE is a gastrointestinal hemorrhage AE that shows occult gastrointestinal hemorrhage.
definition editor: JX, LW, YH
Chinese translation: 胃肠道隐匿性出血

nitrate headache AE
type: Class
subclass of: headache AE
definition: Nitrate headache AE is a headache AE that that is a special headache induced by nitrate.
definition editor: JX, LW, YH
Chinese translation: 硝酸盐性头痛

pantomorphia erythema exudativum AE
type: Class
subclass of: skin AE
definition: Pantomorphia erythema exudativum AE is a skin AE that is a skin condition of unknown cause, possibly mediated by deposition of immune complex (mostly IgM) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. It is an uncommon disorder, with peak incidence in the second and third decades of life.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Erythema_multiforme
Chinese translation: 多形性渗出性红斑

high hypodynamia AE
type: Class
subclass of: fatigue AE
definition: High hypodynamia AE is a fatigue AE that is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities.
definition editor: JX, LW, YH
Chinese translation: 高度乏力

short-time nausea AE
type: Class
subclass of: nausea AE
definition: Short-time nausea AE is a nausea AE that shows a gastric discomfort associated with the inclination to vomit.
definition editor: JX, LW, YH
Chinese translation: 短暂的恶心

slightly increased aspartic transaminase AE
type: Class
subclass of: aspartate aminotransferase level increased AE
definition: Slightly increased aspartic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of AST which is an enzyme normally present in body tissues especially of the heart and liver,
definition editor: JX, LW, YH
Chinese translation: 门冬氨酸氨基转移酶轻度升高

slightly increased alanine aminotransferase AE
type: Class
subclass of: alanine aminotransferase level increased AE
definition: Slightly increased alanine aminotransferase AE is a alanine aminotransferase level increased AE that shows elevated levels of alanine transaminase slightly.
definition editor: JX, LW, YH
Chinese translation: 丙氨酸氨基转移酶轻度升高

slightly increased lactic dehydrogenase AE
type: Class
subclass of: blood lactate dehydrogenase level increased AE
definition: Slightly increased lactic dehydrogenase AE is a blood lactate dehydrogenase level increased AE that shows a slightly increased amount of LDH which is an enzyme that could indicate tissue damage.
definition editor: JX, LW, YH
Chinese translation: 乳酸脱氢酶轻度升高

slightly increased alkaline phosphatase AE
type: Class
subclass of: blood alkaline phosphatase increased AE
definition: Slightly increased alkaline phosphatase AE is a blood alkaline phosphatase increased AE that shows elevated levels of alkaline phosphatase slightly.
definition editor: JX, LW, YH
Chinese translation: 碱性磷酸酶轻度升高

slightly increased glutamic-oxalacetic transaminase AE
type: Class
subclass of: aspartate aminotransferase level increased AE
definition: Slightly increased glutamic-oxalacetic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of glutamic-oxalacetic transaminase in the heart and liver.
definition editor: JX, LW, YH
Chinese translation: 谷草转氨酶轻度升高

slightly increased glutamic pyruvic transaminase AE
type: Class
subclass of: alanine aminotransferase level increased AE
definition: Slightly increased glutamic pyruvic transaminase AE is a alanine aminotransferase level increased AE that shows eelevated levels of glutamic pyruvic transaminase in the liver.
definition editor: JX, LW, YH
Chinese translation: 谷丙转氨酶轻度升高

transient ischemic stroke AE
type: Class
subclass of: ischemic stroke AE
definition: Transient ischemic stroke AE is a ischemic stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain.
definition editor: JX, LW, YH
Chinese translation: 暂时性缺血性中风

evidently increased hepatic lipase AE
type: Class
subclass of: hepatic enzyme increased AE
definition: Evidently increased hepatic lipase AE is a hepatic enzyme increased AE that shows an evidently increase in amount of hepatic enzyme in body, commonly includes ALT and AST. It may indicate inflammation or damage to liver cells.
definition editor: JX, LW, YH
Chinese translation: 肝酶显著增加

mild decline in blood pressure AE
type: Class
subclass of: hypotension AE
definition: Mild decline in blood pressure AE is a hypotension AE that shows mild sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
Chinese translation: 血压轻度下降

transient cerebral ischemic attacks AE
type: Class
subclass of: cerebral ischemia AE
definition: Transient cerebral ischemic attacks AE is a cerebral ischemia AE that shows the sudden death of brain cells in a localized area due to inadequate blood flow.
definition editor: JX, LW, YH
Chinese translation: 短暂脑缺血发作

transient hypotension AE
type: Class
subclass of: hypotension AE
definition: Transient hypotension AE is a hypotension AE that shows transient sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
Chinese translation: 瞬时低血压

obviously decreased blood pressure AE
type: Class
subclass of: hypotension AE
definition: Obviously decreased blood pressure AE is a hypotension AE that shows obviously sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
alternative term: significantly decreased blood pressure AE
Chinese translation: 血压明显下降

transient dizzy AE
type: Class
subclass of: dizziness AE
definition: Transient dizzy AE is a dizziness AE that shows transient dizziness.
definition editor: JX, LW, YH
Chinese translation: 瞬时头晕

short-time hepatic function disorder AE
type: Class
subclass of: hepatic function abnormal AE
definition: Short-time hepatic function disorder AE is a hepatic function abnormal AE that shows a short-time abnormal functionality of the liver.
definition editor: JX, LW, YH
Chinese translation: 短暂肝功能异常

a slightly elevated plasma creatinine level AE
type: Class
subclass of: blood creatinine level increased AE
definition: A slightly elevated plasma creatinine level AE is a blood creatinine level increased AE that shows an slightly increased level of creatinine in the blood (due to lack of kidney activity).
definition editor: JX, LW, YH
Chinese translation: 血浆肌酐水平的轻微升高

sudden fall of blood pressure AE
type: Class
subclass of: hypotension AE
definition: Sudden fall of blood pressure AE is a hypotension AE that shows sudden sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
Chinese translation: 血压突然降低

severe hypertension AE
type: Class
subclass of: hypotension AE
definition: Severe hypertension AE is a hypotension AE that shows severe sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
Chinese translation: 严重高血压

severe arrhythmia AE
type: Class
subclass of: arrhythmia AE
definition: Severe arrhythmia AE is an arrhythmia AE that shows severe abnormal heart rhythm.
definition editor: JX, LW, YH
Chinese translation: 严重心律失常

clinically significant rise of serum transaminase AE
type: Class
subclass of: transaminase level increased AE
definition: Clinically significant rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly.
definition editor: JX, LW, YH
Chinese translation: 血清转氨酶有临床显著升高

instantaneous sand-blind AE
type: Class
subclass of: vision blurred AE
definition: Instantaneous sand-blind AE is a vision blurred AE that shows in instantaneous unclear vision.
definition editor: JX, LW, YH
Chinese translation: 瞬时视觉模糊

moderately increased urinary nitrogen AE
type: Class
subclass of: blood urea level increased AE
definition: Moderately increased urinary nitrogen AE is a blood urea level increased AE that shows a moderately increase in amount of urea in blood.
definition editor: JX, LW, YH
Chinese translation: 尿素中度升高

slightly increased urinary nitrogen AE
type: Class
subclass of: blood urea level increased AE
definition: Slightly increased urinary nitrogen AE is a blood urea level increased AE that shows a slightly increase in amount of urea in blood.
definition editor: JX, LW, YH
Chinese translation: 尿素水平轻微升高

moderately elevated serum creatinine AE
type: Class
subclass of: blood creatinine level increased AE
definition: Moderately elevated serum creatinine AE is a blood creatinine level increased AE that shows an moderately increased level of creatinine in the blood (due to lack of kidney activity).
definition editor: JX, LW, YH
Chinese translation: 血肌酐中度升高

slightly increased aminotransferase AE
type: Class
subclass of: transaminase level increased AE
definition: Slightly increased aminotransferase AE is a transaminase level increased AE that shows slightly elevated levels of alanine transaminase and aspartate transaminase.
definition editor: JX, LW, YH
Chinese translation: 轻度氨基转氨酶升高

severe dizziness AE
type: Class
subclass of: dizziness AE
definition: Severe dizziness AE is a dizziness AE that shows severe dizziness.
definition editor: JX, LW, YH
Chinese translation: 严重眩晕

mild abdominal discomfort AE
type: Class
subclass of: abdominal discomfort AE
definition: Mild abdominal discomfort AE is a abdominal discomfort AE that shows a mild stomach ache.
definition editor: JX, LW, YH
Chinese translation: 轻微腹部不适

serum potassium concentration of moderately reduced
type: Class
subclass of: blood potassium decreased
definition: A blood potassium decreased quality where the amount of potassium in the blood is moderately decreased.
definition editor: JX, LW, YH, MW
Chinese translation: 血清钾浓度的轻度降低

rebound Increased blood pressure AE
type: Class
subclass of: hypertension AE
definition: Rebound Increased blood pressure AE is a hypertension AE that shows rebound sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
Chinese translation: 反跳性血压升高

excessive lowering of blood pressure AE
type: Class
subclass of: hypotension AE
definition: Excessive lowering of blood pressure AE is a hypotension AE that shows excessive sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
Chinese translation: 血压过度降低

short-time increased blood sugar AE
type: Class
subclass of: blood glucose level increased AE
definition: Short-time increased blood sugar AE is a blood glucose level increased AE that shows a short-time increased glucose level in blood.
definition editor: JX, LW, YH
Chinese translation: 短暂血糖升高

mild nausea AE
type: Class
subclass of: nausea AE
definition: Mild nausea AE is a nausea AE that shows mild nausea.
definition editor: JX, LW, YH
Chinese translation: 轻度恶心

significant and persistent rise of serum transaminase AE
type: Class
subclass of: transaminase level increased AE
definition: Significant and persistent rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently.
definition editor: JX, LW, YH
Chinese translation: 血清氨基转移酶显著和持续性升高

elevated serum transaminase reversibility AE
type: Class
subclass of: transaminase level increased AE
definition: Elevated serum transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly.
definition editor: JX, LW, YH
Chinese translation: 血清氨基转移酶可逆性升高

reversible increased creatine phosphokinase AE
type: Class
subclass of: blood creatine phosphokinase level increased AE
definition: Reversible increased creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an reversible increased level of creatine phosphokinase or phosphocreatine kinase.
definition editor: JX, LW, YH
Chinese translation: 肌酸磷酸激酶可逆性升高

persistent and significant increase of serum transaminase AE
type: Class
subclass of: transaminase level increased AE
definition: Persistent and significant increase of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently.
definition editor: JX, LW, YH
Chinese translation: 血清转氨酶显著和持续性升高

severe bradycardia AE
type: Class
subclass of: bradycardia AE
definition: Severe bradycardia AE is a bradycardia AE that shows in a resting heart rate of under 60 beats per minutes (BPM).
definition editor: JX, LW, YH
Chinese translation: 严重心动过缓

apparent hypotensive reaction AE
type: Class
subclass of: hypotension AE
definition: Apparent hypotensive reaction AE is a hypotension AE that shows apparent sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
definition editor: JX, LW, YH
Chinese translation: 显著的低血压反应

severe skin flush AE
type: Class
subclass of: hot flushes AE
definition: Severe skin flush AE is a hot flush AE that shows severe hot flush.
definition editor: JX, LW, YH
Chinese translation: 显著皮肤潮红

transient sinus cardiac arrest AE
type: Class
subclass of: sinus arrest AE
definition: Transient sinus cardiac arrest AE is a sinus arrest AE that shows an electrocardiographic finding of transient impulse formation failure in the sinus node.
definition editor: JX, LW, YH
Chinese translation: 瞬时窦性停搏

low-grade gastralgia AE
type: Class
subclass of: stomach ache AE
definition: Low-grade gastralgia AE is a stomacheache AE that shows a low-grade painful sensation in the stomach.
definition editor: JX, LW, YH
Chinese translation: 轻度胃痛

severe headache AE
type: Class
subclass of: headache AE
definition: Severe headache AE is a headache AE that shows severe headache.
definition editor: JX, LW, YH
Chinese translation: 严重头痛

persistent headache AE
type: Class
subclass of: headache AE
definition: Persistent headache AE is a headache AE that shows persistent headache.
definition editor: JX, LW, YH
Chinese translation: 持续头痛

proarrhythmic effect AE
type: Class
subclass of: arrhythmia AE
definition: Proarrhythmic effect AE is an arrhythmia AE that is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias.
definition editor: JX, LW, YH
alternative term: arhythmia auxo-action AE
definition source: WEB: http://en.wikipedia.org/wiki/Proarrhythmia
Chinese translation: 致心律失常
has_MedDRA_id: 10036766

acidosis AE
type: Class
subclass of: metabolism, endocrine or exocrine system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000949
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a metabolism, endocrine, and exocrine system AE that has an outcome of acidosis, i.e., too much acid in the body fluids.
alternative term: Blood pH Decreased
definition source: URL: http://www.nlm.nih.gov/medlineplus/ency/article/001181.htm
has_MedDRA_id: 10000486
has_MedDRA_id: 10005706
creator: YH, SJ, MW

increased tendency of biliary calculus AE
type: Class
subclass of: hepatobiliary or pancreatic AE
definition: Increased tendency of biliary calculus AE is a liver, biliary, and pancreatic AE that shows an increased tendency of biliary calculus.
definition editor: JX, LW, YH
Chinese translation: 胆石增加的趋势

temporarily lose consciousness AE
type: Class
subclass of: sensory capability AE
definition: Temporarily lose consciousness AE is a sensory capability AE that shows temporarily lose consciousness.
definition editor: JX, LW, YH
Chinese translation: 暂时失去知觉

increase breast cancer occurrence AE
type: Class
subclass of: breast cancer AE
definition: Increase breast cancer occurrence AE is a breast cancer AE that shows increase breast cancer occurrence.
definition editor: JX, LW, YH
Chinese translation: 乳腺癌发生增加

anticholinergic effect AE
type: Class
subclass of: conduction system disorder AE
definition: Anticholinergic effect AE is a conduction system disorder AE that is physical symptoms resulting from agents that counter the action of acetylcholine, a neurotransmitter (chemical within the nervous system) that is involved in many major bodily functions. These anticholinergic effects typically include constipation, dry mouth, blurred vision, dizziness, and slowing of urination.
definition editor: JX, LW, YH
definition source: WEB: http://ibs.about.com/od/glossary/g/Anticholeffect.htm
Chinese translation: 经讯号传导阻断效应

acquired diaphragmatic eventration AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal system AE that has an outcome of diaphragmatic muscle replaced by fibroelestic tissue. The diaphragm retains its continuity and attachments to the costal margin. However, the weakened hemidiaphragm is displaced into the thorax, which can compromise breathing.
definition editor: SJ, YH
definition source: URL: http://www.uptodate.com/contents/eventration-of-the-diaphragm-in-infants
has_MedDRA_id: 10000486

neutrophilopenia AE
type: Class
subclass of: neutrophil count decreased AE
definition: Neutrophilopenia AE is a neutrophil count decreased AE that shows the number of neutrophil is decreased.
definition editor: JX, LW, YH
Chinese translation: 中性白细胞减少

abnormal leucocyte neutrophil AE
type: Class
subclass of: neutrophil percentage abnormal AE
definition: Abnormal leucocyte neutrophil AE is a neutrophil percentage abnormal AE that shows abnormal leucocyte neutrophil.
definition editor: JX, LW, YH
Chinese translation: 嗜中性白细胞异常

abnormal eosinocyte AE
type: Class
subclass of: eosinophil count abnormal AE
definition: Abnormal eosinocyte AE is an eosinophil count abnormal AE that shows abnormal eosinocyte.
definition editor: JX, LW, YH
Chinese translation: 嗜酸性粒细胞异常

eosinopenia AE
type: Class
subclass of: eosinophil count abnormal AE
definition: Eosinopenia AE is an eosinophil count abnormal AE that is a form of agranulocytosis where the number of eosinophil granulocytes is lower than expected.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Eosinopenia
Chinese translation: 嗜酸细胞减少症
has_MedDRA_id: 10014940

aggravated peptic ulcer AE
type: Class
subclass of: duodenal ulcer AE
definition: Aggravated peptic ulcer AE is a duodenal ulcer AE that shows aggravated peptic ulcer.
definition editor: JX, LW, YH
Chinese translation: 消化性溃疡加重

local tissue necrosis AE
type: Class
subclass of: necrosis AE
definition: Local tissue necrosis AE is a necrosis AE that shows local tissue necrosis.
definition editor: JX, LW, YH
Chinese translation: 局部组织坏死

acute myocardial infarction AE
type: Class
subclass of: cardiac disorder AE
subclass of: Restriction
  on property: is evidence of
  some values from: arteriosclerosis coronary artery AE
subclass of: Restriction
  on property: is evidence of
  some values from: toxin-induced cardiomyopathy AE
subclass of: Restriction
  on property: is evidence of
  some values from: cardiac embolism AE
definition: a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by diminished blood supply to the heart
definition editor: SJ, YH
definition source: URL: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/acute-myocardial-infarction/
has_MedDRA_id: 10000891

acute adrenal crisis AE
type: Class
subclass of: endocrine system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002369
definition: an endocrine system AE that results in a life threatening condition due to a lack of cortisol produced by the adrenal glands
definition editor: SJ, YH
definition source: URL: http://www.nlm.nih.gov/medlineplus/ency/article/000357.htm
has_MedDRA_id: 10001389

allodynia AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition editor: YH, SJ
definition source: URL http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2814%2970102-4/abstract
has_MedDRA_id: 10053552
comment: a pain AE that results in pain from a stimulus that does not usually provoke pain

amniotic fluid embolism AE
type: Class
subclass of: embolism AE
definition: an embolism AE in which amniotic fluid, fetal cells, hair or other debris enter the maternal circulation resulting in cardiorespiratory collapse
definition editor: SJ, YH
alternative term: Anaphylactoid Syndrome of Pregnancy
definition source: WEB: http://emedicine.medscape.com/article/253068-overview
has_MedDRA_id: 10001977

diabetic amyotrophy AE
type: Class
subclass of: muscular weakness AE
definition: a muscular weakness AE that has an outcome of weakness followed by wasting of muscles, and excruciating pain in the muscles of the thigh, hip, and buttocks
definition editor: YH, SJ
alternative term: diabetic lumbosacral radiculoplexus neuropathy
alternative term: diabetic polyradiculoneuropathy
alternative term: proximal diabetic neuropathy
has_MedDRA_id: 10002027

anesthetic complication AE
type: Class
subclass of: adverse drug event
definition: an adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment
definition editor: SJ, YH
definition source: WEB: https://www.dha.gov.ae/EN/Facilities/Hospitals/RashidHospital/SpecializedMedicalService/ClinicalServices/Anesthesiologyandinterventionalpain/pages/sideeffects.aspx
has_MedDRA_id: 10060938

anal fistula AE
type: Class
subclass of: OAE_0004229
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an anus AE that results in the development of a small channel between the end of the bowel and the skin near the anus
definition editor: SJ, YH
definition source: WEB: http://www.webmd.boots.com/digestive-disorders/anal-fistula
has_MedDRA_id: 10002156
see also: CTCAE: E10464
see also: NCIt: C60785

postoperative anemia AE
type: Class
subclass of: anemia AE
subclass of: Restriction
  on property: preceded by
  some values from: surgery
definition: postoperative anemia AE is an anemia AE that occurs when a patient with acute bleeding loses enough blood to become anemic
definition editor: SJ, YH
alternative term: bleeding and acute blood loss anemia
definition source: WEB: http://www.acphospitalist.org/archives/2012/02/coding.htm
has_MedDRA_id: 10054312

anger AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in antagonism toward someone or something you feel has deliberately done you wrong: excessive anger can cause problems including increased blood pressure and other physical changes that make it difficult to think straight and can harm your physical and mental health.
definition editor: SJ, YH
definition source: WEB: http://apa.org/topics/anger/index.aspx
has_MedDRA_id: 10002368

adhesion AE
type: Class
subclass of: musculoskeletal or connective tissue AE
subclass of: surgery adverse event
definition: a musculoskeletal system AE that results in the formation of fibrous band between tissues and organs, often as a result of injury during surgery
definition editor: SJ, YH
definition source: URL: http://en.wikipedia.org/wiki/Adhesion_%28medicine%29
has_MedDRA_id: 10059837

pseudobulbar affect AE
type: Class
subclass of: crying abnormal AE
definition: a crying abnormal AE that refers to a neurologic disorder characterized by involuntary crying or uncontrollable episodes of crying and/or laughing, or other emotional displays
definition editor: YH, SJ
alternative term: emotional incontinence
alternative term: emotional lability
alternative term: labile affect
definition source: WEB: http://en.wikipedia.org/wiki/Pseudobulbar_affect
has_MedDRA_id: 10054196

angiopathy AE
type: Class
subclass of: vascular disorder AE
definition: cardiovascular AE that results in disease of the arteries, veins, and capillaries
definition editor: SJ, YH
alternative term: macroangiopathy
alternative term: microangiopathy
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853
has_MedDRA_id: 10059245

microangiopathy AE
type: Class
subclass of: angiopathy AE
definition: a cardiovascular AE that results in the walls of small blood vessels becoming so thick and weak that they bleed, leak protein, and slow the flow of blood
definition editor: SJ, YH
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853
has_MedDRA_id: 10062198

macroangiopathy AE
type: Class
subclass of: angiopathy AE
definition: a cardiovascualr AE that results in the build up of fat and blood clots in the large blood vessels, stick to the vessel walls, and block the flow of blood
definition editor: SJ, YH
alternative term: cerebrovascular disease
alternative term: coronary artery disease
alternative term: peripheral vascular disease
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853
has_MedDRA_id: 10054805

ankyloglossia AE
type: Class
subclass of: muscle AE
definition: a muscle AE that results in a congenital anomaly in which a short, lingual frenulum or a highly-attached genioglossus muscle restricts tongue movement
definition editor: SJ, YH
alternative term: tongue-tie
definition source: WEB: http://www.uptodate.com/contents/ankyloglossia-tongue-tie-in-infants-and-children
has_MedDRA_id: 10049244

anorectal disorder AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE that results in a group of medical disorders that occur at the junction of the anal canal and the rectum
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Anorectal+Disorders
has_MedDRA_id: 10002644

antepartum hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: a hemorrhage AE that has an outcome of bleeding from or in to the genital tract, occurring from 24 weeks of pregnancy and prior to the birth of the baby.
definition editor: YH, SJ
definition source: WEB: https://www.rcog.org.uk/globalassets/documents/guidelines/gtg63_05122011aph.pdf
has_MedDRA_id: 10055228

apallic syndrome AE
type: Class
subclass of: brain damage AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
definition: Brain damage AE that results in a persistent vegetative state
definition editor: SJ, YH
definition source: WEB: http://www.rightdiagnosis.com/a/apallic_syndrome/intro.htm
has_MedDRA_id: 10002941

APGAR score low AE
type: Class
subclass of: investigation result abnormal AE
definition: APGAR is a quick test performed on a neonate at 1 and 5 minutes after birth. The 1-minute score determines how well the baby tolerated the birthing process. The 5-minute score tells the doctor how well the baby is doing outside the mother's womb. Any score lower than 7 is a sign that the baby needs medical attention. The lower the score, the more help the baby needs to adjusting outside the mother's womb
definition editor: YH, SJ
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003402.htm
has_MedDRA_id: 10002944
has_MedDRA_id: 10062552

aphasia AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain disorder AE that causes a person to lose the ability to communicate. Aphasia can affect the ability to express and understand language, both verbal and written. Aphasia typically occurs suddenly after a stroke or a head injury, but it can also come on gradually from a slowly growing brain tumor or a degenerative disease
definition editor: SJ, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/aphasia/basics/definition/con-20027061
has_MedDRA_id: 10002948

arachnoid cyst AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000955
definition: a tumor AE that results in pouches of cerebrospinal fluid covered by arachnoidal cells and collagen that may develop between the surface of the brain and the cranial base or on the arachnoid membrane
definition editor: SJ, YH
definition source: WEB:http://en.wikipedia.org/wiki/Arachnoid_cyst
has_MedDRA_id: 10049005

arachnoiditis AE
type: Class
subclass of: brain inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a brain disorder AE that causes inflammation of the arachnoid, one of the membranes known as meninges that surround and protect the nerves of the central nervous system, including the brain and spinal cord.
definition editor: SJ, YH, MW
definition source: WEB: http://en.wikipedia.org/wiki/Arachnoiditis
has_MedDRA_id: 10003074

arrested labor AE
type: Class
subclass of: pregnancy AE
definition: A pregnancy AE that results in an interruption in the labor process that is associated with uterine contractions.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/arrested+labor
has_MedDRA_id: 10003118

supraventricular arrhythmia AE
type: Class
subclass of: arrhythmia AE
definition: an arrhythmia AE that is characterized by shortness of breath, heart palpitations, chest tightness, and a very fast pulse. Supraventricular arrhythmias begin in the areas above the heart’s lower chambers, such as the upper chambers (the atria) or the atrial conduction pathways.
definition editor: SJ, YH
alternative term: atrial arrhythmia
definition source: WEB: http://www.texasheart.org/HIC/Topics/cond/arrhycat.cfm
has_MedDRA_id: 10003130

coronary arteriospasm AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE which causes a spasm of the large- or medium-sized coronary arteries
definition editor: SJ, YH
alternative term: coronary artery spasm
alternative term: coronary artery vasospasm
alternative term: coronary vasospasm
definition source: WEB: http://sideeffects.embl.de/se/C0010073/pt
has_MedDRA_id: 10003225

arthrofibrosis AE
type: Class
subclass of: joint range of motion decreased AE
definition: joint range of motion decreased AE caused by an excessive amount of scar tissue forming within the joint and surrounding soft tissue spaces
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Arthrofibrosis
has_MedDRA_id: 10058029

arteriosclerosis AE
type: Class
subclass of: cardiovascular AE
definition: arteriosclerosis AE is a cardiovascular AE that results in blood vessels and arteries becoming thick and stiff which can restrict blood flow to organs and tissues.
definition editor: SJ, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972
has_MedDRA_id: 10003210

atherosclerosis AE
type: Class
subclass of: arteriosclerosis AE
definition: atheroslcerosis AE is a specific arteriosclerosis AE that refers to the buildup of fats, cholesterol and other substances in and on artery walls which can restrict blood flow.
definition editor: SJ, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972
has_MedDRA_id: 10003601

atrial tachycardia AE
type: Class
subclass of: tachycardia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: atrial tachycardia AE is a tachycardia AE that results in a fast heart rate beginning in the upper chambers of the heart
definition editor: SJ, YH
alternative term: paroxysmal atrial tachycardia
alternative term: paroxysmal supraventricular tachycardia
alternative term: supraventricular tachycardia
definition source: WEB: http://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/Tachycardia-Fast-Heart-Rate_UCM_302018_Article.jsp#
has_MedDRA_id: 10003668
has_MedDRA_id: 10034040
see also: CTCAE: E10166
see also: NCIt: C34900

blood cortisol increased AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that results in high blood cortisol levels
definition editor: SJ, YH
definition source: URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm
has_MedDRA_id: 10005458
comment: blood cortisol decreased AE may indicate that the patient has cushing disease, ectopic cushing syndrome, or a tumor of the adrenal gland that is producing too much cortisol.

idiopathic thrombocytopenic purpura AE
type: Class
subclass of: cardiovascular AE
definition: a cardiovascular disorder AE that results in easy or excessive bruising and bleeding. The bleeding results from unusually low levels of platelets.
definition editor: SJ, YH
alternative term: immune thrombocytopenic purpura
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/basics/definition/con-20034239
has_MedDRA_id: 10050245

bladder pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000916
definition editor: YH, SJ
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2477
has_MedDRA_id: 10005063
comment: a pain AE that is observed in the bladder, usually a symptom of bladder infection.

blepharospasm AE
type: Class
subclass of: eye AE
definition: an eye AE that results in involuntary, forcible closure of the eyelids.The spasms may leave the eyelids completely closed, causing functional blindness even though the eyes and vision are normal.
definition editor: SJ, YH
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2481
has_MedDRA_id: 10005159

amaurosis fugax AE
type: Class
subclass of: abnormal vision AE
definition: an abnormal vision AE which has an outcome of loss of vision in one eye that is not permanent.
definition editor: SJ, YH
alternative term: blindness unilateral
definition source: WEB: http://en.wikipedia.org/wiki/Amaurosis_fugax
has_MedDRA_id: 10005186

blood cortisol decreased AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that results in low blood cortisol levels
definition editor: SJ, YH
definition source: URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm
has_MedDRA_id: 10005457
comment: blood cortisol decreased AE may indicate that the patient has addison disease, hypopituitarism, suppression of normal pituitary or adrenal function.

blood creatine increased AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that results in high blood creatine levels
definition editor: SJ, YH
definition source: URL: http://www.mayoclinic.org/tests-procedures/creatinine/basics/definition/prc-20014534
has_MedDRA_id: 10005464
comment: blood creatine increased AE may indicate that the kidneys are not fucntioning properly

bone graft procedure
type: Class
subclass of: surgery
definition: a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly
definition editor: YH, SJ
has_MedDRA_id: 10005971

blood immunoglobin E increased AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that signifies that a patient is allergic to a particular substance
definition editor: SJ, YH
definition source: WEB: http://kidshealth.org/parent/system/medical/test_ige.html
has_MedDRA_id: 10005591

blood testosterone decreased AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that results in low levels of testosterone which can lead to infertility and a low sex drive
definition editor: SJ, YH
definition source: WEB: http://www.webmd.com/men/testosterone-15738
has_MedDRA_id: 10005814

macrocytic anemia AE
type: Class
subclass of: anemia AE
definition: A macrocytic anemia AE is an anemia AE that has an outcome of a macrocytic anemia, which is an anemia (defined as blood with an insufficient concentration of hemoglobin) in which the red blood cells (erythrocytes) are larger than their normal volume.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Macrocytic_anemia
has_MedDRA_id: 10002064

low bone density AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that has an outcome of low bone densityl, but not low enough to be considered osteoporosis
definition editor: SJ, YH
definition source: WEB: http://nof.org/articles/9
has_MedDRA_id: 10049470

bone graft AE
type: Class
subclass of: surgery adverse event
subclass of: Restriction
  on property: preceded by
  some values from: bone graft procedure
definition: a surgical AE that occurs after a bone graftr procedure, which replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly.
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Bone_grafting

bone marrow edema AE
type: Class
subclass of: edema AE
definition: bone marrow edema AE is an edema AE that occurs when excess fluids in the bone marrow buildup and cause swelling. This condition is often caused by a protective reaction of the body in response to an injury or inflammation
definition editor: SJ, YH
definition source: WEB: http://www.wisegeek.com/what-is-bone-marrow-edema.htm
has_MedDRA_id: 10051763

bone scan abnormal AE
type: Class
subclass of: investigation result abnormal AE
definition: an investigation result abnormal AE that detects areas of increased or decreased bone activity. These may indicate bone injury or disease.
definition editor: SJ, YH
definition source: WEB: http://www.mountsinai.org/patient-care/health-library/treatments-and-procedures/bone-scan
has_MedDRA_id: 10061941

brachial plexus injury AE
type: Class
subclass of: nervous system AE
definition: Nervous system AE that covers a variety of conditions that may impair function of the brachial plexus nerve network, most of which are caused by trauma.
definition editor: SJ, YH
definition source: WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/peripheral_nerve_surgery/conditions/brachial_plexus_injury_bpi.html
has_MedDRA_id: 10006074

bradyarrhythmia AE
type: Class
subclass of: decreased heart rate AE
definition: a bradycardia AE that results in a disturbance in the heart rhythm in which the heart rate is abnormally slowed.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/bradyarrhythmia
has_MedDRA_id: 10049765

bradycardia fetal AE
type: Class
subclass of: decreased heart rate AE
definition: a bradycardia AE that results in a fetal heart rate of less than 120 beats per minute, generally associatedwith hypoxia
definition editor: SJ, YH
definition source: WEB:http://medical-dictionary.thefreedictionary.com/fetal+bradycardia
has_MedDRA_id: 10006094

brain death AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain disorder AE that results in the complete and irreversible loss of brain function
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Brain_death
has_MedDRA_id: 10049054

brain herniation AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain disorder AE that results in brain tissue, cerebrospinal fluid, and blood vessels being moved or pressed away from their usual position inside the skull.
definition editor: SJ, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001421.htm
has_MedDRA_id: 10006126

brain injury AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain injury AE, injury to the brain caused by an external force, that results in a brain AE
definition editor: SJ, YH
alternative term: Traumatic Brain Injury
definition source: WEB: http://www.biausa.org/FAQRetrieve.aspx?ID=43913
has_MedDRA_id: 10067967

brain mass AE
type: Class
subclass of: tumor AE
definition: a brain mass AE is a mass or growth of abnormal cells in your brain or close to your brain
definition editor: SJ, YH
alternative term: Brain Neoplasm
alternative term: Brain Tumor
alternative term: Intercranial Neosplasm
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/brain-tumor/home/ovc-20117132
has_MedDRA_id: 10052334
has_MedDRA_id: 10061019

brain scan abnormal AE
type: Class
subclass of: imaging investigation result abnormal AE
definition: an imaging investigation result abnormal AE shows how the brain and its tissues are working. Abnormal results may be due to: Alzheimer’s disease or dementia, brain tumors, epilepsy, and movement disorders.
definition editor: SJ, YH
alternative term: PET scan
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007341.htm
has_MedDRA_id: 10061943

eyelid disorder AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0001711
subclass of: eye AE
definition: Eyelid disorder AE is a eye AE that is a condition specifically affects the eyelid. It can include drooping, twitching, inflammation, paralysis, and growths. Occasional fluttering of one eyelid is normal.
definition editor: JX, LW
definition source: WEB: http://www.healthline.com/health/eyelid-disorders#Overview1
has_MedDRA_id: 10061130

hepatic steatosis AE
type: Class
subclass of: liver AE
definition: Hepatic steatosis AE is a liver disorder AE than popularly called as ‘fatty liver’ is a pathological aspect of liver, whose specific cells (hepatocytes) are filled with lipids (fats). It is a reversible liver disease: ‘is not still very ill, but cries for help’.
definition editor: JX, LW
definition source: WEB: http://www.bendomd.com/272-hepatic-steatosis-causes-symptoms-treatment.html
has_MedDRA_id: 10019708

abdominal injury AE
type: Class
subclass of: abdominal pain AE
subclass of: joint disorder AE
definition: An arthropathy AE is a joint pain AE that has an outcome of arthropahty, which is any disorder of the joints.
definition: This is an AE which is an injury to the abdomen and its signs and symptoms include abdominal pain, tenderness, rigidity, and bruising of the external abdomen.
definition editor: KM, YH
definition editor: QY, JX, HY
definition source: WEB: http://en.wikipedia.org/wiki/Arthropathy, http://medical-dictionary.thefreedictionary.com/arthropathy
definition source: http://en.volupedia.org/wiki/Abdominal_trauma
Chinese translation: 腹部损伤
has_MedDRA_id: 10003285
has_MedDRA_id: 10060924
label: arthropathy AE
see also: NCIT: C35760

balanitis AE
type: Class
subclass of: reproductive system AE
definition: A balantis AE is a reproductive system AE that has an outcome of a balantis, which is an infectious or non-infectious inflammatory process that affects the glans penis. Symptoms include redness and pain of the glans penis and foreskin and discharge.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000862.htm, http://en.wikipedia.org/wiki/Balanitis
has_MedDRA_id: 10004073

pruritus genital AE
type: Class
subclass of: pruritus AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0004122
definition: Pruritus genital AE is a pruritus AE that also called genital itching, Itching in the genital region can result from irritation, allergy, inflammation, infection or cancer. Irritation can occur as a result of exposure to chemicals in soaps, feminine hygiene products, perfumes, lubricants, douches, and creams.
definition editor: JX, LW
alternative term: genital itching AE
definition source: WEB: http://www.healthgrades.com/symptoms/genital-itching
has_MedDRA_id: 10037093

cholecystitis AE
type: Class
subclass of: gallbladder enlargement AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002110
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: cholecystitis AE is an gallbladder enlargement AE that has an outcome of cholecystitis, which is an acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Cholecystitis, http://www.mayoclinic.org/diseases-conditions/cholecystitis/basics/definition/con-20034277
has_MedDRA_id: 10008612
see also: CTCAE: E11184
see also: NCIT: C34465
see also: NCIt: C34465

chromaturia AE
type: Class
subclass of: urine abnormality AE
definition: Chromaturia AE is an urine abnormality AE that has an outcome of chromaturia, which is an abnormal coloration of the urine.
definition editor: KM, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/chromaturia
has_MedDRA_id: 10008796

chromosome abnormality AE
type: Class
subclass of: genetic AE
definition: Chromosome abnormality AE is a genetic AE that has an outcome of chromsome abnormality which is a missing, extra, or irregular protion of chromosomal DNA.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Chromosome_abnormality
has_MedDRA_id: 10008815

coagulopathy AE
type: Class
subclass of: blood disorder AE
definition: A coagulopathy AE is a blood disorder AE that has an outcome of coagulopathy, which is a condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Coagulopathy
has_MedDRA_id: 10009802

combined immunodeficiency AE
type: Class
subclass of: immune system AE
definition: Combined immunodeficiency AE is an immune system AE that has an outcome of combined immunodeficiency, which represents a group of rare, sometimes fatal, congenital disorders characterized by little or no immune response.
definition editor: KM, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/books/NBK22254/
has_MedDRA_id: 10010099

hepatic enzyme abnormal AE
type: Class
subclass of: liver related investigation result abnormal AE
definition: Hepatic enzyme abnormal AE is a liver related investigation result abnormal AE that the lab test result of hepatic enzyme deviates from its normal value.
definition editor: JX, YH
has_MedDRA_id: 10062685

coronary artery aneurysm AE
type: Class
subclass of: coronary artery disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001621
definition: A coronary artery aneurysm AE is a coronary artery disorder AE that has an outcome of coronary artery aneurysm, which is a coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Coronary_artery_aneurysm
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/9247557
has_MedDRA_id: 10011071

injection site atrophy AE
type: Class
subclass of: injection-site AE
definition: Injection site atrophy AE is an injection-site AE that muscle atrophy occur in the injection site.
definition editor: JX, YH
has_MedDRA_id: 10022048

cutaneous tuberculosis AE
type: Class
subclass of: tuberculosis AE
definition: A cutaneous tuberculosis AE is a tuberculosis AE that has an outcome of cutaneous tuberculosis, which is an invasion of the skin by Mycobacterium tuberculosis.
definition editor: KM, YH
definition source: WEB: http://www.dermnetnz.org/bacterial/tuberculosis.html
has_MedDRA_id: 10011684

breath sounds abnormal AE
type: Class
subclass of: respiratory system AE
definition: Breath sounds abnormal AE is a respiratory system AE that is characterized by abnormal breath sound, it can indicate fluid in the lungs or asthma.
definition editor: JX, LW
definition source: WEB: http://www.healthline.com/health/breath-sounds#Overview1
has_MedDRA_id: 10064780

skin abrasion AE
type: Class
subclass of: skin AE
definition: Skin abrasion AE is a skin AE that is a wound caused by superficial damage to the skin, no deeper than the epidermis.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Abrasion_%28medical%29
has_MedDRA_id: 10064990

trigeminal neuralgia AE
type: Class
subclass of: neuralgia AE
definition: Trigeminal neuralgia AE is a neuralgia AE that is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. The clinical association between TN and hemifacial spasm is the so-called tic douloureux.
definition editor: JX, YH
alternative term: Fothergill's disease AE
alternative term: prosopalgia AE
definition source: WEB: http://en.wikipedia.org/wiki/Trigeminal_neuralgia
has_MedDRA_id: 10044652

face injury AE
type: Class
subclass of: injury AE
definition: Face injury AE is an injury AE that injury occurs in the face.
definition editor: JX, YH
has_MedDRA_id: 10050392

muscle contrature AE
type: Class
subclass of: muscle AE
definition: Muscle contrature AE is a muscle AE that can occur for many reasons, such as paralysis, muscular atrophy, and forms of muscular dystrophy. Fundamentally, the muscle and its tendons shorten, resulting in reduced flexibility.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Muscle_contracture
has_MedDRA_id: 10062575

gaze palsy AE
type: Class
subclass of: OAE_0004344
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0000970
definition: A palsy AE that has a symmetric limitation of the movements of both eyes in the same direction.
definition editor: JX, YH
definition source: WEB: http://one.aao.org/bcscsnippetdetail.aspx?id=f5a77965-de2a-4fb0-82fb-5f4089671ad6
has_MedDRA_id: 10056696

conjugate gaze palsy AE
type: Class
subclass of: gaze palsy AE
definition: Conjugate gaze palsy AE is a gaze palsy AE that is a disorder affecting the ability to move both eyes in the same direction. These palsies can affect gaze in a horizontal, upward, or downward direction.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Conjugate_gaze_palsy

horizontal gaze palsy AE
type: Class
subclass of: gaze palsy AE
definition: Horizontal gaze palsy AE is a gaze palsy AE that is the paresis of conjugate eye movements.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Horizontal_gaze_palsy

posture abnormal AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavioral and neurological AE that refers to rigid body movements and chronic abnormal positions of the body. This symptom is not the same as showing poor posture or slumping over. Rather, it is often the result of a serious spinal cord or brain injury.
definition editor: JX, YH
definition source: WEB: http://www.healthline.com/symptom/posture-abnormal
has_MedDRA_id: 10036436

tonic clonic movements AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavioral and neurological AE that shows the body becomes entire rigid and uncontrolled jerking. They may last mere seconds, or continue for several minutes.
definition editor: JX, YH
has_MedDRA_id: 10051171

eyelid ptosis AE
type: Class
subclass of: eyelid disorder AE
definition: Eyelid ptosis AE is an eye disorder AE that is a drooping or falling of the upper or lower eyelid.
definition editor: JX, LW
definition source: WEB: http://en.wikipedia.org/wiki/Ptosis_%28eyelid%29
has_MedDRA_id: 10015995

facial paresis AE
type: Class
subclass of: paresis AE
definition: Facial paresis AE is a paresis AE that is a common problem that involves the paralysis of any structures innervated by the facial nerve.
definition editor: JX, YH
alternative term: facial nerve paralysis AE
definition source: WEB: http://en.wikipedia.org/wiki/Facial_nerve_paralysis
has_MedDRA_id: 10051267

menstrual disorder AE
type: Class
subclass of: female reproductive system AE
definition: Menstrual disorder AE is an abnormal condition in a woman's menstrual cycle.
definition source: WEB: http://en.wikipedia.org/wiki/Menstrual_disorder
has_MedDRA_id: 10027327
creator: JX, YH

fluid retention AE
type: Class
subclass of: abnormal fluid regulation AE
definition: Fluid retention AE is an abnormal fluid regulation AE that is excess fluid that collects in the tissues in your body. Most commonly, fluid retention is marked by swelling of your feet and lower legs, but swelling could also occur in your arms, hands, face, or other areas of the body.
definition editor: JX, YH
definition source: WEB: http://www.healthgrades.com/symptoms/fluid-retention
has_MedDRA_id: 10016807

emotional distress AE
type: Class
subclass of: emotional disorder AE
definition: Emotional distress AE is a emotional disorder AE that is a Mental distress or anxiety suffered as a response to a sudden, severe, and saddening experience.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Emotional_distress
has_MedDRA_id: 10049119

encephalitis AE
type: Class
subclass of: brain inflammation AE
definition: Encephalitis AE is a nervous system AE that is an acute inflammation of the brain.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Encephalitis
has_MedDRA_id: 10014581

cognitive disorder AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that is a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Cognitive_disorder
has_MedDRA_id: 10057668

incoherent AE
type: Class
subclass of: speech disorder AE
definition: Incoherent AE is a speech disorder AE that shows unable to express one's thoughts or ideas in an orderly, intelligible manner.
definition editor: JX, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/incoherent
has_MedDRA_id: 10021630

exercise tolerance decreased AE
type: Class
subclass of: systematic AE
definition: Exercise tolerance decreased AE is a systematic AE that shows exercise tolerance decreased. The exercise tolerance refers to the exercise capacity of an individual as measured by their ability to endure exercise and/or the maximum work load achieved during the exercise period.
definition editor: JX, YH
definition source: WEB: http://copd.about.com/od/glossaryofcopdterms/g/activitytoleran.htm
has_MedDRA_id: 10051301

thermal burn AE
type: Class
subclass of: burn AE
definition: a burn AE that is a type of burn resulted from making contact with heated objects, such as boiling water, steam, hot cooking oil, fire, and hot objects.
definition editor: JX, LW
definition source: WEB: http://en.wikipedia.org/wiki/Thermal_burn
has_MedDRA_id: 10053615

dissociation AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that describes a wide array of experiences from mild detachment from immediate surroundings to more severe detachment from physical and emotional experience.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Dissociation_%28psychology%29
has_MedDRA_id: 10013457

acupuncture
type: Class
subclass of: medical intervention
definition: Acupuncture is the stimulation of specific acupuncture points along the skin of the body using thin needles. It can be associated with the application of heat, pressure, or laser light to these same points.
definition editor: JX, LW
definition source: WEB: http://en.wikipedia.org/wiki/Acupuncture
has_MedDRA_id: 10000646

mucous membrane disorder AE
type: Class
subclass of: systematic AE
definition: Mucous membrane disorder AE is a systematic AE that the diseases occur in mucous membrane, which is a lining of mostly endodermal origin.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Mucous_membrane
has_MedDRA_id: 10028133

demyelinating polyneuropathy AE
type: Class
subclass of: polyneuropathy AE
definition: a polyneuropathy AE that arises when the myelin sheaths around nerve cells are damaged. Myelin, the insulating layer of tissue that surrounds nerve cells, helps ensure that signals from the brain are rapidly transmitted to the proper places in the body. When myelin is damaged or destroyed, it can lead to problems with communication between the brain and the body.
definition editor: JX, YH
definition source: WEB: http://www.healthgrades.com/conditions/chronic-inflammatory-demyelinating-polyneuropathy
has_MedDRA_id: 10061811

compartment syndrome AE
type: Class
subclass of: syndrome AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002385
definition: a syndrome AE that results in increased pressure in a muscle compartment which can lead to nerve damage and impaired blood flow.
definition editor: SJ, YH
definition source: URL: http://www.nlm.nih.gov/medlineplus/ency/article/001224.htm
has_MedDRA_id: 10010121
comment: Thick layers of tissue, called fascia, separate groups of muscles in the arms and legs from each other. Inside each layer of fascia is a confined space, called a compartment. The compartment includes the muscle tissue, nerves, and blood vessels.

therapeutic response decreased
type: Class
subclass of: therapy adverse event
definition: Therapeutic response decreased is found among people who take Cialis, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Aspirin, and have Erection problems.
definition editor: JX, LW
definition source: WEB: http://www.ehealthme.com/ds/cialis/therapeutic+response+decreased
has_MedDRA_id: 10043414

bed rest
type: Class
subclass of: medical intervention
definition: Bed rest is a medical treatment in which a person lies in bed for most of some period of time to gain health benefits.
definition editor: JX, LW
definition source: WEB: http://en.wikipedia.org/wiki/Bed_rest
has_MedDRA_id: 10050118

complex partial seizure AE
type: Class
subclass of: seizure AE
definition: a seizure AE that resutls in impariment of awareness and involuntary but coordinated and repeated movements.
definition editor: YH, SJ
definition source: WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2
has_MedDRA_id: 10010145

autoimmune disorder AE
type: Class
subclass of: immune system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: Autoimmune disorder AE is an immune system AE that arises from an abnormal immune response of the body against substances and tissues normally present in the body (autoimmunity).
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Autoimmune_disease
has_MedDRA_id: 10061664
see also: CTCAE: E11258
see also: NCIt: C2889

brainstem hemorrhage AE
type: Class
subclass of: hemorrhage AE
definition: a hemorrhage AE that has an outcome of bleeding into the pons or mesencephalon.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/brainstem+hemorrhage
has_MedDRA_id: 10006146
comment: brain stem hemorrhage AE is often secondary to brainstem distortion due to rapidly expanding intracranail lessions.

menstruation irregular AE
type: Class
subclass of: menstrual disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Menstruation irregular AE is a endocrine system AE that is an abnormal variation in length of menstrual cycles in a female.
definition editor: JX, YH, MW
alternative term: irregular menstruation AE
definition source: WEB: http://en.wikipedia.org/wiki/Irregular_menstruation
has_MedDRA_id: 10022992
has_MedDRA_id: 10027339
see also: CTCAE: E13125
see also: NCIt: C35219

generalised tonic-clonic seizure AE
type: Class
subclass of: seizure AE
definition: Generalised tonic-clonic seizure AE is a seizure AE that is a type of generalized seizure that affects the entire brain. Tonic–clonic seizures are the seizure type most commonly associated with epilepsy and seizures in general, though it is a misconception that they are the only type.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Tonic%E2%80%93clonic_seizure
has_MedDRA_id: 10018100

posturing AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that an involuntary flexion or extension of the arms and legs, indicating severe brain injury.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Abnormal_posturing
has_MedDRA_id: 10036437

off label drug use
type: Class
subclass of: drug administration
definition: Off label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, unapproved dosage, or unapproved form of administration.
definition editor: JX, LW
alternative term: off label use
definition source: WEB: http://en.wikipedia.org/wiki/Off-label_use
has_MedDRA_id: 10053762

demyelination AE
type: Class
subclass of: nervous system AE
definition: Demyelination AE is a nervous system AE that is any disease of the nervous system in which the myelin sheath of neurons is damaged.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Demyelinating_disease
has_MedDRA_id: 10012305

gram stain negative AE
type: Class
subclass of: microbiology and serology investigation result abnormal AE
definition: Gram stain negative AE is a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-negative bacteria.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Gram-negative_bacteria
has_MedDRA_id: 10018656

red blood cells CSF positive AE
type: Class
subclass of: CSF test result abnormal AE
definition: Red blood cells CSF positive AE is a CSF test result abnormal AE that has an outcome of CSF red blood cells count positive.
definition editor: JX, YH
has_MedDRA_id: 10038173

CSF white blood cell count increased AE
type: Class
subclass of: CSF test result abnormal AE
definition: CSF white blood cell count increased AE is a CSF test result abnormal AE that has an outcome of CSF white blood cell count increased.
definition editor: JX, YH
has_MedDRA_id: 10053805

influenza A virus test positive AE
type: Class
subclass of: influenza virus test positive AE
definition: Influenza A virus test positive AE is a influenza virus test positive AE that has an outcome of positive result in an influenza A virus test.
definition editor: JX, YH
has_MedDRA_id: 10070215

nerve conduction study abnormal AE
type: Class
subclass of: behavioral and neurological test abnormal AE
definition: a behavior and neurological test abnormal AE that shows a abnormal result of nerve conduction study (NCS). NCS is a medical diagnostic test commonly used to evaluate the function, especially the ability of electrical conduction, of the motor and sensory nerves of the human body.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Nerve_conduction_study
has_MedDRA_id: 10029175

myocardial necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
definition: Myocardial necrosis AE is a cardiac disorder AE that shows death of the cells of an area of the heart muscle (myocardium) as a result of oxygen deprivation, which in turn is caused by obstruction of the blood supply.
definition editor: JX, YH
definition source: URL: http://medical-dictionary.thefreedictionary.com/myocardial+necrosis
has_MedDRA_id: 10028602

brainstem infarction AE
type: Class
subclass of: stroke AE
definition: a brainstem infarction AE is a stroke AE that occurs when blood cannot flow to the brainstem, when oxygen cannot get to an area of the brain, tissue in that area may be damaged.
definition editor: SJ, YH
alternative term: brainstem stroke
definition source: WEB: http://en.wikipedia.org/wiki/Brain_stem_stroke_syndrome
definition source: WEB: http://www.drugs.com/cg/brain-stem-infarction.html
has_MedDRA_id: 10006147
comment: A person may have vertigo, dizziness and severe imbalance without the hallmark of most strokes – weakness on one side of the body. But dizziness alone is not a sign of stroke. Brain stem stroke can also cause diplopia, slurred speech and decreased level of consciousness.

breath sounds decreased AE
type: Class
subclass of: lung AE
definition: a lung disorder AE that occurs when the noises produced by the structures of the lungs during breathing are decreased or absent.
definition editor: SJ, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007535.htm
has_MedDRA_id: 10006333
comment: Absent or decreased breath sounds can indicate air or fluid around the lungs, increased thickness of chest wall, over-inflation of part of the lungs, or reduced airflow to part of the lungs.

Brugada syndrome AE
type: Class
subclass of: syndrome AE
definition: a syndrome AE that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death.
definition editor: SJ, YH
alternative term: sudden adult death syndrome (SADS)
definition source: WEB: http://en.wikipedia.org/wiki/Brugada_syndrome
has_MedDRA_id: 10059027

buttock pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000978
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: Buttock pain AE is a pain AE that is a common problem in the butt, it can be due to bursitis, bruising, piriformis syndrome, and shingles,or due to more serious diseases with long-term consequences, such as cancer, arthritis of the sacroiliac joints, and herniated disc with sciatica.
definition editor: SJ, YH, MW
alternative term: Butt Pain
definition source: WEB:http://www.medicinenet.com/buttock_pain/symptoms.htm
has_MedDRA_id: 10048677

calcinosis AE
type: Class
subclass of: digestive system AE
definition: a digestive system AE with an outcome of small white calcium lumps forming under the skin that may leak a chalky white fluid. These lumps are formed becuase of too much calcium in the diet.
definition editor: SJ, YH
definition source: WEB: http://www.sclero.org/medical/symptoms/skin/calcinosis.html
has_MedDRA_id: 10006938
comment: These most commonly occur on the hands, or near joints such as elbows or knees, although they may appear anywhere. Calcinosis may range from one very tiny deposit, to large (and often painful) clusters.

candidiasis AE
type: Class
subclass of: infection AE
definition: an infection adverse event that caused by a species of the yeast Candida.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/candidiasis
has_MedDRA_id: 10007152
comment: This is a common cause of vaginal infections in women. Also, Candida may cause mouth infections in people with reduced immune function, or in patients taking certain antibiotics. Candida can be found in virtually all normal people but causes problems in only a fraction.

cardiac enzymes increased AE
type: Class
subclass of: hematology investigation result abnormal AE
definition: a hematology investigation result abnormal AE that occurs when the cardaic enzymes and proteins leak out of damaged heart muscle cells, and their levels in the bloodstream rise.
definition editor: SJ, YH
definition source: URL: http://www.webmd.com/heart-disease/cardiac-enzyme-studies
has_MedDRA_id: 10007548
comment: cardiac enzymes increased AE may indicate that the heart muscle is injured, such as from a heart attack.

acute decompensated heart failure AE
type: Class
subclass of: cardiac failure AE
definition: Acute decompensated heart failure AE is a cardiovascular disorder AE that shows a worsening of the symptoms, typically shortness of breath (dyspnea), edema, and fatigue, in a patient with existing heart disease.
definition editor: SJ, YH
alternative term: Cardiac Failure Acute
definition source: WEB: http://en.wikipedia.org/wiki/Acute_decompensated_heart_failure
has_MedDRA_id: 10007556
has_MedDRA_id: 10064653

cardiac massage
type: Class
subclass of: medical intervention
definition: Cardiac massage is a resuscitative procedure that employs the rhythmic compression of the chest and heart in an effort to restore and maintain the circulation after cardiac arrest or ventricular fibrillation
definition editor: SJ, YH
alternative term: Heart Massage
definition source: WEB: http://www.thefreedictionary.com/cardiac+massage
has_MedDRA_id: 10059163

cardiac murmur AE
type: Class
subclass of: cardiac disorder AE
definition: Cardiac murmur AE is a cardiac disorder AE that is characterised by abnormal sounds during the heartbeat cycle — such as whooshing or swishing — made by turbulent blood in or near the heart.
definition editor: SJ, YH
alternative term: Heart Murmur
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/heart-murmurs/basics/definition/con-20028706
has_MedDRA_id: 10007586

catatonia AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that is seen most frequently in schizophrenia, characterized by muscular rigidity and mental stupor, sometimes alternating with great excitement and confusion.
definition editor: YH, SJ
definition source: WEB: http://dictionary.reference.com/browse/catatonia
has_MedDRA_id: 10007776

carotid artery stenosis AE
type: Class
subclass of: coronary artery disorder AE
definition: a coronary artery disorder AE that results in narrowing of the inner surface of the carotid atery.
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Carotid_artery_stenosis
has_MedDRA_id: 10007687

orbital cellulitis AE
type: Class
subclass of: eye AE
definition: orbital cellulitis AE is a sudden infection of the tissues around the eye, affecting the eyelid, eyebrow, and cheek.
definition editor: SJ, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001012.htm
has_MedDRA_id: 10007918

chronic cholecystitis AE
type: Class
subclass of: coronary artery aneurysm AE
definition: Chronic cholecystitis AE the inflammation of the gallbladder persisting for a prolonged period of time or having repeated attacks.
definition editor: SJ, YH
definition source: WEB: http://www.healthline.com/health/chronic-cholecystitis#Overview1
has_MedDRA_id: 10008617

brain lesion AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain lesion AE is an area of injury or disease within the brain.
definition editor: SJ, YH
definition source: WEB: http://www.webmd.com/brain/brain-lesions-causes-symptoms-treatments
has_MedDRA_id: 10051290

central venous pressure increased AE
type: Class
subclass of: investigation result abnormal AE
definition: Central venous pressure increased AE is a mesaurement of the pressure of the blood within the superior and inferior vena cava and large veins of the body. Increased pressure can be the result of cardiac failure and congestion of circulation.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/central+venous+pressure
has_MedDRA_id: 10007980

brain disorder AE
type: Class
subclass of: brain AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002037
definition: a brain disorder AE occurs when the brain is damaged by injury, disease, or health conditions.
definition editor: SJ, YH
definition source: WEB: http://www.healthline.com/health/brain-disorders#Overview1
has_MedDRA_id: 10054938
comment: Brain disorders may affect the main areas of your brain that control how you move, think, and behave. Some tumors can constrict the blood vessels in your brain.

cerebral infarction AE
type: Class
subclass of: ischemic stroke AE
definition: a cerebral infarction is a type of ischaemic stroke AE that is caused by a blockage in the blood vessels supplying blood to the brain.
definition editor: SJ
definition source: WEB: http://en.wikipedia.org/wiki/Cerebral_infarction
has_MedDRA_id: 10008118

cerebrospinal fluid leak AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a nervous system AE that occurs when the cerebrospinal fluid leaks through a defect in the dura or the skull and out through the nose or ear resulting from a tear in the dura.
definition editor: SJ, YH, MW
alternative term: cerebrospinal fluid leakage AE
definition source: WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/brain_tumor/center/skull-base/types/csf-leak.html
has_MedDRA_id: 10008164
see also: CTCAE: E12611
see also: NCIt: C50487

cervical dysplasia AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that refers to abnormal changes in the cells on the surface of the cervix. The changes are not cancer. But they can lead to cancer of the cervix if not treated.
definition editor: SJ, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001491.htm
has_MedDRA_id: 10008263

cervical radiculopathy AE
type: Class
subclass of: bone AE
definition: a bone disorder AE that results in pain and neurological symptoms resulting from any type of condition that irritates a nerve in the cervical spine.
definition editor: SJ, YH
definition source: WEB: http://www.spine-health.com/conditions/neck-pain/what-cervical-radiculopathy
has_MedDRA_id: 10008303

cervical spinal stenosis AE
type: Class
subclass of: nervous system AE
definition: Cervical spinal stenosis AE is a nervous system AE that occurs when the spinal canal in the neck narrows.
definition editor: SJ, YH
definition source: WEB: http://www.webmd.com/back-pain/tc/cervical-spinal-stenosis-topic-overview
has_MedDRA_id: 10008313

choking AE
type: Class
subclass of: respiratory system AE
definition: a respiratory AE that results in the inability to breath because something gets stuck in the throat or because the air is not good for breathing
definition editor: SJ, YH
definition source: WEB: http://www.merriam-webster.com/dictionary/choke
has_MedDRA_id: 10008589

chondrolysis AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal and connective tissue AE that results in tlhe disappearance of articular cartilage as the result of disintegration or dissolution of the cartilage matrix and cells.
definition editor: SJ, YH
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=17184
has_MedDRA_id: 10058112

chondromalacia AE
type: Class
subclass of: joint disorder AE
definition: A joint disorder AE in which the cartilage on the undersurface of the patella deteriorates and softens.
definition editor: SJ, YH
definition source: WEB: http://www.healthline.com/health/chondromalacia-patella#Overview1
has_MedDRA_id: 10008729

therapy adverse event
type: Class
subclass of: adverse event
subclass of: Restriction
  on property: preceded by
  some values from: therapeutic intervention
definition: an adverse event that occurs after a therapeutic intervention
definition editor: YH, JX

physiotherapy
type: Class
subclass of: therapeutic intervention
definition: a therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention
definition editor: YH, JX
alternative term: physical therapy
definition source: WEB: http://en.wikipedia.org/wiki/Physical_therapy

simple partial seizure AE
type: Class
subclass of: seizure AE
definition: a seizure AE that resutls in jerking and muscle rigidity, unusual sensations affecting vision, hearing, smell, taste or touch, and memory or emothional disturbances.
definition editor: YH, SJ
definition source: WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2
has_MedDRA_id: 10040703

chemosis AE
type: Class
subclass of: conjunctival disorder AE
definition: chemosis AE is a conjunctival disorder AE that results in swelling of the conjunctiva die to exudation of abnormaly permeable capillaries.
definition editor: SJ, YH
alternative term: conjunctival edema
definition source: WEB: http://en.wikipedia.org/wiki/Chemosis
has_MedDRA_id: 10053163

continuous venovenous hemodiafiltration
type: Class
subclass of: therapeutic intervention
definition: a therapeutic intervention that is used in critically ill patients who have experienced multisystem organ failure and in whom acute renal failure has developed.
definition editor: YH, SJ
definition source: WEB: http://www.medilexicon.com/medicaldictionary.php?t=40071
has_MedDRA_id: 10066348

conversion disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in the expression of psychlogical stress in physical ways or a mental or emotional crises that begins to have a physical affect.
definition editor: YH, SJ
alternative term: functional neurological symptom disorder
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/conversion-disorder/basics/definition/con-20029533
has_MedDRA_id: 10010893

coronary arteriosclerosis AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE which causes a thickening and loss of elasticity of the coronary arteries, leading to progressive insufficiency of the arteries.
definition editor: SJ, YH
alternative term: arteriosclerotic coronary artery disease
alternative term: coronary artery atherosclerosis
definition source: WEB: http://ghr.nlm.nih.gov/glossary=coronaryarteriosclerosis
has_MedDRA_id: 10011076

coronary occlusion AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE which causes a partial or complete blockage of the coronary artery which can lead to heart attack.
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Coronary_occlusion
has_MedDRA_id: 10011086

coronary artery disease AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE which results in inflammation and the buildup of plaque which narrow the coronary arteries.
definition editor: SJ, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/coronary-artery-disease/basics/definition/con-20032038
has_MedDRA_id: 10011089

crepitation AE
type: Class
subclass of: joint disorder AE
definition: An joint disorder AE that results in the noise produced by the rubbing together of bone or irregular cartilage surfaces.
definition editor: YH, SJ
definition source: WEB: http://medical-dictionary.thefreedictionary.com/crepitation
has_MedDRA_id: 10011376

cryptorchidism AE
type: Class
subclass of: male reproductive system AE
definition: cryptorchidism AE is a male reproductive system AE which results in the absence of one or both testes from the scrotum.
definition editor: YH, SJ
alternative term: undescended testis
definition source: WEB: http://en.wikipedia.org/wiki/Cryptorchidism
has_MedDRA_id: 10011498

decreased CSF glucose AE
type: Class
subclass of: CSF test result abnormal AE
definition: CSF glucose is proportional to blood glucose levels which correspond to 60-70% of the concentration in blood.
definition editor: SJ, YH
alternative term: hypoglycorrhachia
has_MedDRA_id: 10011537
comment: decreased CSF glucose AE can be caused by CNS infections, inflammatory conditions, subarachnoid hemorrhage, hypoglycemia, impaired glucose transport, increased CNS glycolytic activity and metastatic carcinoma.

wound culture positive AE
type: Class
subclass of: investigation result abnormal AE
definition: wound culture positive AE is a a test to find and identify germs that may be growing on the skin or in a wound. If something that can cause infection grows, the culture is positive. The type of organisms may be identified with a microscope, chemical tests, or both.
definition editor: SJ, YH
definition source: WEB: http://www.webmd.com/a-to-z-guides/skin-and-wound-cultures
has_MedDRA_id: 10011643

skin cyst AE
type: Class
subclass of: skin AE
definition: skin cyst AE is a skin AE that occurs when a cluster of cells that have grouped together to form a sac which may contain air, fluids, or semi-solid material.
definition editor: YH, SJ
alternative term: cyst
definition source: WEB: http://en.wikipedia.org/wiki/Cyst
has_MedDRA_id: 10011732

conductive hearing loss AE
type: Class
subclass of: hearing loss AE
definition: conductive hearing loss AE is a hearing loss AE that results from probelms with the ear canal, ear drum, or middle ear and its little bones.
definition editor: SJ, YH
alternative term: sensorineural hearing loss (SNHL)
definition source: WEB: http://www.hearingloss.org/content/types-causes-and-treatment
has_MedDRA_id: 10010282

transient hearing loss AE
type: Class
subclass of: hearing loss AE
definition: transient hearing loss AE is a hearing loss AE that results from poor ventilation of the middle ear in children.
definition editor: SJ, YH
alternative term: deafness transitory
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139416/
has_MedDRA_id: 10011900

delusion AE
type: Class
subclass of: psychiatric disorder AE
definition: a psychiatric disorder AE that results in a persistent false psychotic belief regarding the self or objects outside the self that is maintained despite indisputable evidence to the contrary.
definition editor: SJ, YH
definition source: WEB: http://www.merriam-webster.com/dictionary/delusion
has_MedDRA_id: 10012239

dependent personality disorder AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavioral and neurological AE that results in long-standing need for the person to be taken care of and a fear of being abandoned or separated from important individuals.
definition editor: SJ, YH
definition source: WEB: http://psychcentral.com/disorders/dependent-personality-disorder-symptoms/
has_MedDRA_id: 10012355
comment: Individuals with Dependent Personality Disorder are often characterized by pessimism and self-doubt, and tend to belittle their abilities and assets. This leads the person to engage in dependent and submissive behaviors that are designed to elicit care-giving behaviors in others.

developmental delay AE
type: Class
subclass of: behavioral and neurological AE
definition: Nervous system AE that results in failure to meet certain developmental milestones, such as sitting, walking, and talking, at the average age. Developmental delay may indicate a problem in development of the central nervous system.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/developmental+delay
has_MedDRA_id: 10012559

diabetic ketoacidosis AE
type: Class
subclass of: cardiovascular AE
definition: diabetic ketoacidosis AE is a cardiovascular AE that develops when your body is unable to produce enough insulin and begins to break down fat as an alternate fuel, this process produces a buildup of toxic acids in the bloodstream called ketones.
definition editor: SJ, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/basics/definition/con-20026470
has_MedDRA_id: 10012671

dialysis
type: Class
subclass of: medical intervention
definition: Dialysis is the process of removing waste products and excess fluid from the body when the kidneys are not able to adequately filter the blood.
definition editor: YH, SJ
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2980
has_MedDRA_id: 10061105

congenital diaphragmatic hernia AE
type: Class
subclass of: congenital AE
definition: congenital diaphragmatic hernia AE is a congential disorder in which an absent or partially formed diaphragm results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. This crowding can lead to underdevelopment of the lungs, potentially resulting in life-threatening breathing difficulties that are apparent from birth.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/aspiration
has_MedDRA_id: 10061106

diplegia AE
type: Class
subclass of: paralysis AE
definition: a paralysis AE that has an outcome of paralysis affecting symmetrical parts of the body.
definition editor: SJ, YH
definition source: WEB: http://en.wikipedia.org/wiki/Diplegia
has_MedDRA_id: 10013033

cystitis interstitial AE
type: Class
subclass of: cystitis AE
definition: cystitis interstitial AE is a cystitis AE that has an outcome of cystitis interstitial, which is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/interstitialcystitis.html
has_MedDRA_id: 10011796

disseminated tuberculosis AE
type: Class
subclass of: tuberculosis AE
definition: A disseminated tuberculosis AE is a tuberculosis AE that has an outcome of disseminated tuberculosis, which is a contagious bacterial infection in which TB bacteria has spread from the lungs to other parts of the body through the blood or lymph system.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000624.htm
has_MedDRA_id: 10013453

exotosis AE
type: Class
subclass of: bone pain AE
definition: Exotosis AE is a bone pain AE that has resulted in a non-neoplastic overgrowth of bone.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Exostosis
has_MedDRA_id: 10015688

exudative retinopathy AE
type: Class
subclass of: eye AE
definition: An exudative retinopathy AE is an eye AE that shows an outcome of exudative retinopathy marked by masses of white or yellowish exudate in the posterior part of the fundus oculi, with deposits of cholesterol and blood debris from retinal hemorrhage, that leads to destruction of the macula and blindness.
definition editor: KM, YH
alternative term: Coats' disease, Coats' retinitis
definition source: WEB: http://medical-dictionary.thefreedictionary.com/exudative+retinopathy
has_MedDRA_id: 10015901

tendinous AE
type: Class
subclass of: tendon disorder AE
definition: A tendon disorder AE that has an outcome of tendinous which is damage to a tendon at a cellular level. It is thought to be caused by microtears in the connective tissue in and around the tendon, leading to an increase in tendon repair cells.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Tendinosis
has_MedDRA_id: 10016662

monocytosis AE
type: Class
subclass of: monocyte percentage abnormal AE
definition: A monocyte percentage abnormal AE that results in abnormally high levels of monocytes in the blood.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Monocytosis
has_MedDRA_id: 10027906
see also: NCIT: C35147

genital candidiasis AE
type: Class
subclass of: reproductive system AE
definition: A male reproductive system AE that has an outcome of genital candidiasis, which is a fungal infection due to any types of Candida (types of yeasts). This is a fungal infection of the genital region.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Candidiasis
definition source: WEB: http://www.cdc.gov/fungal/diseases/candidiasis/genital/
has_MedDRA_id: 10018143

groin pain AE
type: Class
subclass of: pain AE
definition editor: KM, YH
definition source: WEB: http://www.webmd.com/pain-management/tc/groin-problems-and-injuries-topic-overview
has_MedDRA_id: 10018735
comment: A groin pain AE is a pain AE that shows a pain in the groin area.

haemolysis AE
type: Class
subclass of: blood disorder AE
definition: A blood disorder AE that has an outcome of the breakdown of red blood cells.
definition editor: KM, YH
alternative term: hemolysis
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002372.htm
has_MedDRA_id: 10018910

hepatosplenomegaly AE
type: Class
subclass of: liver inflammation AE
definition: A hepatosplenomegaly AE is a liver inflammation AE that has an outcome of an abnormal enlargement of the liver and spleen.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/imagepages/17215.htm
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3716
has_MedDRA_id: 10019847

hiatus hernia AE
type: Class
subclass of: gastric disorder AE
definition: A gastric disorder AE that occurs when part of your stomach pushes upward through your diaphragm.
definition editor: KM, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/hiatal-hernia/basics/definition/con-20030640
has_MedDRA_id: 10020028

HIV infection AE
type: Class
subclass of: viral infection AE
definition: A viral infection AE that is caused by the human immunodeficiency virus.
definition editor: KM, YH
has_MedDRA_id: 10020161
see also: NCIT: C3108

hypertonic bladder AE
type: Class
subclass of: digestive system AE
definition: A hypertonic bladder AE is a digestive system AE that where the bladder-storage function that causes a sudden urge to urinate.
definition editor: SJ, YH
alternative term: irritable bladder
alternative term: overactive bladder
definition source: WEB: http://healbladder.info/healbladder/hypertonic-bladder
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/overactive-bladder/basics/definition/con-20027632
has_MedDRA_id: 10020853

hypovitaminosis AE
type: Class
subclass of: gustatory system AE
definition: A hypovitaminosis AE is a gustatory system AE which shows an insufficiency of one or more essential vitamins.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Hypovitaminosis
has_MedDRA_id: 10021135

ileitis AE
type: Class
subclass of: gastrointestinal disorder AE
definition: A gastrointestinal disorder AE that shows the inflammation of the ileum.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Ileitis
has_MedDRA_id: 10021312
see also: NCIT: C84782

joint dislocation AE
type: Class
subclass of: joint disorder AE
definition: A joint pain AE that occurs when there is an abnormal separation in the joint, where two or more bones meet.
definition editor: KM, YH
alternative term: dislocated joint, luxation
definition source: WEB: http://en.wikipedia.org/wiki/Joint_dislocation
has_MedDRA_id: 10023204

kawasaki disease AE
type: Class
subclass of: syndrome AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001637
definition: A syndrome AE that shows Kawasaki's disease, a vasculitis characterized by inflammation of the arteries, particularly the coronary arteries. The vasculitis may lead to aneurysm formation and possibly, heart attacks. It affects young children who usually present with persistent high fever, redness of the mucous membranes of the mouth, redness of the palms and soles, skin rashes, lymphadenitis, and joint pain and swelling.
definition editor: KM, YH
alternative term: Mucocutaneous Lymph Node Syndrome
definition source: WEB: http://en.wikipedia.org/wiki/Kawasaki_disease
has_MedDRA_id: 10023320
see also: NCIT: C34825

liver abscess AE
type: Class
subclass of: abscess AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002107
definition: An abscess AE where a bacterial, parasitic, or fungal abscess that develops in the liver. It is usually the result of an abdominal infection, trauma, or surgery in the right upper quadrant. Signs and symptoms include abdominal pain, nausea, vomiting, and fever.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Liver_abscess
has_MedDRA_id: 10024652
see also: NCIT: C99089

lividity AE
type: Class
subclass of: blood disorder AE
definition: A blood disorder AE that the body's blood supply will stop moving after the heart has stopped pumping it around the inside of the deceased.
definition editor: KM, YH
definition source: WEB: http://www.exploreforensics.co.uk/rigor-mortis-and-lividity.html
has_MedDRA_id: 10024728

lymphangitis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001473
definition: A lymphangitis AE is an inflammation AE that has an infection of the lymph vessels (channels).
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007296.htm
has_MedDRA_id: 10025226

malaria AE
type: Class
subclass of: infection AE
example of usage: An infection adverse event that results in malaria, a protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Malaria
has_MedDRA_id: 10025487
see also: NCIT: C34797

metabolic acidosis AE
type: Class
subclass of: metabolic disorder AE
definition: A metabolic disoder AE where there is increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock.
definition editor: KM, YH
alternative term: Acidosis
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000335.htm
has_MedDRA_id: 10027417
see also: NCIT: C28228

mucous stool AE
type: Class
subclass of: abnormal stool AE
definition: An abnormal stool AE that has an outcome of a significant amount of mucus in the stool. The mucus is accompanied by diarrhea, pain or blood may signify an intestinal condition such as infection or inflammation. Increased amounts of mucus in the stool can also occur with cancers of the colon or rectum or with bowel obstruction.
definition editor: KM, YH
definition source: WEB: http://www.healthgrades.com/symptoms/mucus-in-stool
has_MedDRA_id: 10028140

muscle spasticity AE
type: Class
subclass of: muscle spasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: A muscle spasm AE that has an outcome of tight or stiff muscles and an inability to control those muscles.
definition editor: KM, YH, MW, MW
alternative term: spasticity AE
definition source: WEB: http://www.webmd.com/pain-management/pain-management-spasticity
has_MedDRA_id: 10028335
has_MedDRA_id: 10041416
see also: CTCAE: E12820
see also: NCIt: C79750

neonatal respiratory distress AE
type: Class
subclass of: respiratory distress AE
definition: A respiratory distress AE that has an outcome of a newborn dyspnea (i.e., impaired breathing) with cyanosis, most frequently occurring in premature infants, children of diabetic mothers and infants delivered by cesarean section, and sometimes with no predisposing cause.
definition editor: KM, YH
alternative term: Newborn Respiratory Distress Syndrome
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001563.htm
has_MedDRA_id: 10001052
see also: NCIT: C27560

neutrophilia AE
type: Class
subclass of: neutrophil count increased AE
definition: A neutrophil count increased AE that has an outcome of an abnormally high level of neutrophils in the blood.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Neutrophilia
has_MedDRA_id: 10029379
see also: NCIT: C35164

orchitis AE
type: Class
subclass of: male reproductive system AE
definition: A male reproductive system AE that results in an inflammation of one or both testes due to viral or bacterial infections. Signs and symptoms include enlargement or tenderness of the affected testis, inguinal lymphadenopathy, blood in the semen, and pain during urination, intercourse, or ejaculation.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001280.htm
has_MedDRA_id: 10031064
see also: NCIT: C97145

osteitis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002481
definition: an inflammation AE that occurs in a bone.
definition editor: KM, YH
alternative term: Osteitis fibrosa
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001252.htm
has_MedDRA_id: 10031149

osteolysis AE
type: Class
subclass of: bone AE
definition: A bone disorder AE that has an dissolution of bone, especially the removal or loss of the calcium of bone.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Osteolysis
has_MedDRA_id: 10031248
see also: NCIT: C50681

palpitations AE
type: Class
subclass of: arrhythmia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: An arrhythmia AE that has an outcome of palpitations, an abnormality of heartbeat characterized by simultaneous awareness of one’s pulse and discomfort.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Palpitations
has_MedDRA_id: 10033557
see also: CTCAE: E10163
see also: NCIt: C37999

papule AE
type: Class
subclass of: skin AE
definition: A skin AE that shows a solid, raised spot on the skin that is up to 0.5 centimeter wide, which is a type of skin lesion.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003233.htm
has_MedDRA_id: 10033733

parotitis AE
type: Class
subclass of: parotid gland enlargement AE
definition: A parotid gladn enlargement AE that has an outcome of parotitis, the inflammation of one or more of the parotid glands.
definition editor: KM, YH
definition source: WEB: http://emedicine.medscape.com/article/882461-overview
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001041.htm
has_MedDRA_id: 10034038

penis disorder AE
type: Class
subclass of: male reproductive system AE
definition: A male reproductive system AE that has an disorder in a penis, including priapism, Peyronie's disease, balanitis, phimosis, paraphimosis, and penile cancer.
definition editor: KM, YH
definition source: WEB: http://www.medicinenet.com/penis_disorders/article.htm
has_MedDRA_id: 10034336

peritonitis AE
type: Class
subclass of: abdominal AE
definition: An abdominal AE that shows an inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Peritonitis
has_MedDRA_id: 10034674
see also: NCIT: C26849

plasmapheresis AE
type: Class
subclass of: medical intervention
definition: A medical intervention that collects plasma from the peripheral blood while returning the rest to the donor.
definition editor: KM, YH
alternative term: plasma exchange
alternative term: therapeutic plasma exchange
definition source: WEB: http://en.wikipedia.org/wiki/Plasmapheresis
has_MedDRA_id: 10035486
see also: NCIT: C15304

polyarthritis AE
type: Class
subclass of: arthritis AE
definition: An arthritis AE that has an outcome of polyarthritis, which includes any type of arthritis that involves 5 or more joints simultaneously.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Polyarthritis
has_MedDRA_id: 10036030

prostatic disorder AE
type: Class
subclass of: male reproductive system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002367
definition: A male reproductive system AE that affects prostatic gland in the male reproductive system.
definition editor: KM, YH
definition source: WEB: http://www.britannica.com/EBchecked/topic/479519/prostatic-disorder
has_MedDRA_id: 10036956

pseudo lymphoma AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002113
definition: A tumor AE that shows a benign disorder of lymphoid cells or histiocytes that produces clinical features of a malignant lymphoma.
definition editor: KM, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pseudolymphoma
has_MedDRA_id: 10037108

pyoderma AE
type: Class
subclass of: skin AE
definition: A skin AE that shows a pyogenic skin disease. These include superficial bacterial infections such as impetigo, impetigo contagiosa, ecthyma, folliculitis, Bockhart's impetigo, furuncle, carbuncle, tropical ulcer, etc.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Pyoderma
has_MedDRA_id: 10037632

pyuria AE
type: Class
subclass of: urine abnormality AE
definition: A urine abnormality AE that shows the presence of white blood cells or pus in the urine, usually a sign of urinary tract infection.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Pyuria
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pyuria
has_MedDRA_id: 10037686

hypernatremia AE
type: Class
subclass of: blood sodium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood sodium increased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood sodium abnormal AE that is characterized by an abnormally high level of sodium in the blood
definition editor: YH, MW
alternative term: hypernaetremia
definition source: WEB: http://emedicine.medscape.com/article/241094-overview
has_MedDRA_id: 10020679
has_MedDRA_id: 10020680
see also: CTCAE: E12293
see also: HPO: HP_0003228
see also: NCIt: C37970
see also: SIDER: C0595878

morbilliform rash AE
type: Class
subclass of: rash AE
definition: A rash AE that shows a rash like measles. The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places.
definition editor: KM, YH
alternative term: measles-like maculopapular rash AE
definition source: WEB: http://en.wikipedia.org/wiki/Morbilliform
definition source: WEB: http://www.wisegeek.com/what-is-a-morbilliform-rash.htm
has_MedDRA_id: 10037870

vesicular rash AE
type: Class
subclass of: rash AE
definition: A rash AE that shows a raised, blistery rash.
definition editor: KM, YH
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=11955
has_MedDRA_id: 10037898

reticulocyte count increased AE
type: Class
subclass of: red blood cell count increased AE
definition: A red blood cell count increased AE that has an increased count of reticulocytes in the blood. Reticulocytes are slightly immature red blood cells.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003637.htm
has_MedDRA_id: 10038792

acute psychosis AE
type: Class
subclass of: behavioral and neurological AE
definition: a behavior and neurological AE that results in impaired or inhibited ego functioning in which the ability to process reality-based information is diminished and disordered.
definition editor: SJ, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/acute+psychosis
has_MedDRA_id: 10001022

retinopathy of prematurity AE
type: Class
subclass of: eye AE
definition: An eye AE that shows an abnormal blood vessel development in the retina of the eye and it occurs in infants that are born too early.
definition editor: KM, YH
alternative term: Terry syndrome
alternative term: retrolental fibroplasia
alternative term: retrolental fibroplasia (RLF)
definition source: WEB: http://en.wikipedia.org/wiki/Retinopathy_of_prematurity
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001618.htm
has_MedDRA_id: 10038933

scar AE
type: Class
subclass of: skin AE
definition: A skin AE that results in a scar, a mark left on the skin.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Scar
has_MedDRA_id: 10039580
see also: NCIT: C34483

scleroderma AE
type: Class
subclass of: autoimmune disorder AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002097
definition: A skin AE that has an outcome of a localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Scleroderma
has_MedDRA_id: 10039710
comment: Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys.
see also: NCIT: C26746

scrotal oedema AE
type: Class
subclass of: edema AE
definition: A male reproductive system AE that has an outcome of an abnormal enlargement of the scrotum, the sac surrounding the testicles.
definition editor: KM, YH
alternative term: scrotal edema
alternative term: scrotal swelling
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003161.htm
has_MedDRA_id: 10039755

skin atrophy AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: A skin AE that results in the degeneration and thinning of the epidermis and dermis.
definition editor: KM, YH, MW
alternative term: atrophy of the skin
definition source: WEB: http://www.wisegeek.com/what-is-skin-atrophy.htm
has_MedDRA_id: 10040799
see also: NCIT: C35163

skin depigmentation AE
type: Class
subclass of: skin discoloration AE
definition: A skin discoloration AE that shows the lightening of the skin, or loss of pigment.
definition editor: KM, YH
alternative term: Depigmentation
definition source: WEB: http://en.wikipedia.org/wiki/Depigmentation
Chinese translation: 皮肤脱色
has_MedDRA_id: 10040825

skin hypopigmentation AE
type: Class
subclass of: skin discoloration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: A skin discoloration AE that shows abnormal lightening of skin due to decreased melanin production or deposition.
definition editor: KM, YH, MW
alternative term: Hypopigmentation, Pigment Dilution
definition source: WEB: http://en.wikipedia.org/wiki/Hypopigmentation
has_MedDRA_id: 10040868
comment: Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation.

spleen disorder AE
type: Class
subclass of: immune system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G4
    union of: AE severity G5
definition: An immune system disorder AE that has an disorder in spleen, the largest organ in the lymphatic system.
definition editor: KM, YH
alternative term: splenic diseases
definition source: WEB: http://en.wikipedia.org/wiki/Splenic_disease
definition source: WEB: http://www.livescience.com/44725-spleen.html
has_MedDRA_id: 10041633
see also: CTCAE: E10056
see also: NCIt: C35823

akinesia AE
type: Class
subclass of: muscle AE
definition: a muscle AE that shows the absence or loss of control of voluntary muscle movements.
definition editor: SJ, YH
definition source: URL: http://medical-dictionary.thefreedictionary.com/akinesia
has_MedDRA_id: 10001541

epileptic seizure AE
type: Class
subclass of: seizure AE
definition: a seizure AE that shows a brief episode of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.
definition editor: JX, YH
alternative term: epilepsy
definition source: WEB: http://en.wikipedia.org/wiki/Epileptic_seizure
Chinese translation: 癫痫

optic neuropathy AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000970
definition: a cranial neuropathy AE which shows an damage or abnormality to the nerves in the eyes.
definition editor: RR, YH
definition source: WEB: http://www.allaboutvision.com/conditions/optic-neuritis.htm
has_MedDRA_id: 10061323

neuroretinitis AE
type: Class
subclass of: optic neuropathy AE
definition: an optic neuropathy AE characterized by optic disc swelling, peripapillary and macular hard exudates, and vitreous cells.
definition editor: RR, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/6466175
has_MedDRA_id: 10060701

anterior ischemic optic neuropathy AE
type: Class
subclass of: ischemic optic neuropathy AE
definition: an optic neuropathy AE characterized by vision loss, optic disc swelling, flame hemorrhages, and cotton-wool exudates. It occurs when blood flow is interrupted to the front (anterior) part of the optic nerve (also called optic nerve head).
definition editor: RR, YH
alternative term: AION
definition source: WEB: http://emedicine.medscape.com/article/1216891-overview
definition source: WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/
has_MedDRA_id: 10068250

non-arteritic anterior ischemic optic neuropathy AE
type: Class
subclass of: anterior ischemic optic neuropathy AE
definition: a type of anterior ischemic optic neuropathy AE that presents primarily with vision loss, especially upon wakening, and sectorial disc edema.
definition editor: RR, YH
definition source: WEB: http://emedicine.medscape.com/article/1216891-clinical#a0217
has_MedDRA_id: 10068249

mixed neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
definition: a peripheral neuropathy AE that shows a combination of axonal and demyelinating neuropathy.
definition editor: RR, YH
definition source: WEB: http://www.aafp.org/afp/2010/0401/p887.html

sensory peripheral polyneuropathy AE
type: Class
subclass of: peripheral sensory neuropathy AE
definition: a peripheral sensory neuropathy AE that shows neuropathy in many sensory nerves at one time
definition editor: RR, YH
definition source: WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html

peripheral demyelinating polyneuropathy AE
type: Class
subclass of: peripheral neuropathy AE
definition: a peripheral neuropathy AE that results from the loss of the myelin sheath on peripheral nerves roughly evenly distributed on both sides of the body
definition editor: RR, YH

diabetic neuropathy AE
type: Class
subclass of: neuropathy AE
definition: a neuropathy AE that shows nerve damage and occurs in a patient with diabetes
definition editor: RR, YH
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/basics/definition/con-20033336
has_MedDRA_id: 10012680

neurological deficit AE
type: Class
subclass of: nervous system AE
definition: a nervous system AE that is an umbrella term referring to conditions relating to the nervous system, including loss of sensation and paralysis
definition editor: RR, YH
definition source: WEB: http://en.wikipedia.org/wiki/Functional_neurological_deficit

staphylococcal abscess AE
type: Class
subclass of: abscess AE
definition: An abscess AE that is caused by an Staphylococcus aureus infection.
definition editor: KM, YH
alternative term: abscess
definition source: http://medical-dictionary.thefreedictionary.com/staphylococcal+abscess
has_MedDRA_id: 10041917

strabismus AE
type: Class
subclass of: eye AE
definition: An eye AE that results in an intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes.
definition editor: KM, YH
alternative term: cross-eyed
alternative term: heterotropia
alternative term: wall-eyed
definition source: WEB: http://en.wikipedia.org/wiki/Strabismus
has_MedDRA_id: 10042159

telangiectasia AE
type: Class
subclass of: vein discoloration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: A vein discoloration AE that has an outcome of local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.
definition editor: KM, YH, MW
definition source: http://en.wikipedia.org/wiki/Telangiectasia
has_MedDRA_id: 10043189
see also: NCIT: C28194

trismus AE
type: Class
subclass of: muscle spasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: A muscle spasm AE that results in the lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication.
definition editor: KM, YH, MW
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=40739
has_MedDRA_id: 10044684
comment: Trismus is a symptom of tetanus.
see also: NCIt: C78651

typhoid fever AE
type: Class
subclass of: bacterial infection AE
definition: A bacterial infection AE with an outcome of thypoid fever, a bacterial infectious disorder caused by the Salmonella typhi bacteria.
definition editor: KM, YH
alternative term: tyhpoid
definition source: WEB: http://www.webmd.com/a-to-z-guides/typhoid-fever
has_MedDRA_id: 10045275
comment: Typhoid fever is often contracted by consumption of food or drink contaminated with Salmonella typhi.
see also: NCIT: C35089

urethritis AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0001088
definition: a urinary system AE that results in the inflammation (swelling and irritation) of the urethra.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000439.htm
has_MedDRA_id: 10046480

vitiligo AE
type: Class
subclass of: skin discoloration AE
definition: a skin discoloration AE which shows a chronic skin disease characterized by portions of the skin losing their pigment.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Vitiligo
Chinese translation: 白癫风；白驳风；白斑
has_MedDRA_id: 10047642
see also: NCIT: C26915

burn AE
type: Class
subclass of: injury AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an injury AE that displays a type of injury to flesh or skin caused by heat, electricity, chemicals, friction, or radiation.
definition editor: YH
definition source: WEB: http://en.wikipedia.org/wiki/Burn
has_MedDRA_id: 10006634
see also: CTCAE: E11669
see also: NCIt: C34441

sedimentation rate decreased AE
type: Class
subclass of: hematopoietic system AE
definition: a hematopoietic system AE which has a decreased erythrocyte sedimentation rate (ESR). EST is the rate at which red blood cells sediment in a period of one hour.
definition editor: KM, YH
alternative term: ESR
alternative term: erythrocyte sedimentation rate
alternative term: red blood cell sedimentation rate decreased AE
definition source: Westergren ESR decreased AE
definition source: http://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate
has_MedDRA_id: 10049188

skin turgor decreased AE
type: Class
subclass of: skin AE
definition: a skin AE that has decreased skin turgor which is the skin's ability to change shape and return to normal (elasticity).
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003281.htm
has_MedDRA_id: 10049428

gastrointestinal stromal tumour AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0005409
definition: A tumor AE that shows a tumor occuring in the gastrointestinal tract.
definition editor: KM, YH
definition source: WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor
has_MedDRA_id: 10051066

fluctuance AE
type: Class
subclass of: bacterial infection AE
definition: A bacterial infection AE that has the presence of pus in a bacterial infection.
definition editor: KM, YH
definition source: WEB: http://dermatology.about.com/library/bldeffluctuance.htm
has_MedDRA_id: 10051723

acinetobacter infection AE
type: Class
subclass of: bacterial infection AE
definition: A bacterial infection AE which is caused by Acinetobacter.
definition editor: KM, YH
definition source: WEB: http://www.cdc.gov/HAI/organisms/acinetobacter.html
has_MedDRA_id: 10051894
comment: Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. Acinetobacter infections rarely occur outside of healthcare settings.

wound AE
type: Class
subclass of: injury AE
definition: an injury AE that breaks the skin or other body tissues.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/woundsandinjuries.html
has_MedDRA_id: 10052428

peritoneal tuberculosis AE
type: Class
subclass of: tuberculosis AE
definition: a tuberculosis AE which is an invasion of the peritoneum by Mycobacterium tuberculosis.
definition editor: KM, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/21215540
has_MedDRA_id: 10053583

haemangioma AE
type: Class
subclass of: tumor AE
definition: a tumor AE that shows a benigh tumor of vascular origin usually seen in early childhood.
definition editor: YH
definition source: WEB: http://radiopaedia.org/articles/haemangioma

vascular occlusion AE
type: Class
subclass of: vascular disorder AE
definition: a vascular disorder AE that has an outcome of the blockage of a blood vessel, usually with a clot.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Vascular_occlusion
has_MedDRA_id: 10053648

joint tuberculosis AE
type: Class
subclass of: tuberculosis AE
definition: a tuberculosis AE that shows an tuberculosis of the joints.
definition editor: KM, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577591/
has_MedDRA_id: 10056367

ventricular arrhythmia AE
type: Class
subclass of: arrhythmia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an arrhythmia AE that shows abnormal heart rhythms that originate in the bottom chambers of the heart called the ventricles.
definition editor: LW, YH
definition source: WEB: http://my.clevelandclinic.org/services/heart/departments-centers/ventricular-arrhythmia-center
Chinese translation: 室性心律失常
has_MedDRA_id: 10047281
see also: CTCAE: E10230
see also: NCIt: C26924

Salmonella AE
type: Class
subclass of: bacterial infection AE
definition: A bacterial infection AE that is caused by Salmonella.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Salmonella
has_MedDRA_id: 10058878

hypokalaemia AE
type: Class
subclass of: blood potassium abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: blood potassium decreased
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a blood potassium abnormal AE that has a lab test outcome of abnormally lower than normal amount of potassium in the blood
definition editor: YH, MW
alternative term: hypokalemia AE
alternative term: hypopotassaemia AE
alternative term: hypopotassemia AE
alternative term: potassium depletion AE
definition source: WEB: http://en.wikipedia.org/wiki/Hypokalemia
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia
definition source: WEB: http://www.emedicinehealth.com/low_potassium/article_em.htm
Chinese translation: 血钾过少
has_MedDRA_id: 10021015
has_MedDRA_id: 10021018
see also: CTCAE: E12327
see also: NCIt: C37974

alpha tumour necrosis factor AE
type: Class
subclass of: necrosis AE
definition: a necrosis AE, tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (adipokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha
has_MedDRA_id: 10059981

oral neoplasm AE
type: Class
subclass of: tumor AE
definition: a tumor AE that that is a benign or malignant neoplasm involving the oral cavity and/or the lips.
definition editor: KM, YH
definition source: WEB: http://www.nlm.nih.gov/medlineplus/oralcancer.html
has_MedDRA_id: 10061325
see also: NCIT: C8989

pericardial disease AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE that can present clinically as acute pericarditis, pericardial effusion, cardiac tamponade, and constrictive pericarditis.
definition editor: KM, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878263/
has_MedDRA_id: 10061338

peritoneal neoplasm AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002113
definition: a tumor AE that shows a benign or malignant neoplasm that affects the peritoneal cavity.
definition editor: KM, YH
definition source: WEB: http://www.webmd.com/cancer/peritoneal-cancer-prognosis-symptoms-treatments
has_MedDRA_id: 10061344
comment: Representative examples of benign neoplasms include adenomatoid tumor and disseminated peritoneal leiomyomatosis. Representative examples of malignant neoplasms include primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma.
see also: NCIT: C3322

purulence AE
type: Class
subclass of: inflammation AE
definition: an inflammation AE that shows the formation or presence of pus.
definition editor: KM, YH
definition source: MedDRA: 10061926
definition source: WEB: http://medical-dictionary.thefreedictionary.com/purulence

mycobacterial infection AE
type: Class
subclass of: bacterial infection AE
definition: a bacterial infection AE with bacteria of the genus Mycobacterium.
definition editor: KM, YH
alternative term: Mycobacterium Infection
definition source: WEB: http://www.nlm.nih.gov/medlineplus/mycobacterialinfections.html
has_MedDRA_id: 10062207
see also: NCIT: C26831

spinal haemangioma AE
type: Class
subclass of: haemangioma AE
definition: a tumor AE that shows the most common benign spinal neoplasm, often located in the thoracic and lumbar spine, with a peak incidence of occurrence in the fourth to sixth decades.
definition editor: KM, YH
definition source: WEB: http://radiopaedia.org/articles/vertebral-haemangioma
has_MedDRA_id: 10065275

Omenn syndrome AE
type: Class
subclass of: syndrome AE
example of usage: a syndrome AE that reuslts in an autosomal recessive combined immunodeficiency syndrome caused by mutations in the RAG-1 and RAG-2 genes. It is characterized by the presence of alopecia, erythroderma, desquamation, lymphadenopathy, and chronic diarrhea.
editor note: YH: This is also a genetic AE. We will later find a way to link to there.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Omenn_syndrome
has_MedDRA_id: 10069097
see also: NCIT: C61240

immunodeficiency AE
type: Class
subclass of: immune system AE
definition: a immune system AE that results in a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.
definition editor: KM, YH
definition source: WEB: http://en.wikipedia.org/wiki/Immunodeficiency

hepatitis C AE
type: Class
subclass of: hepatitis viral AE
definition: a hepatitis AE that resutls in a hepatitis C viral infection.
definition editor: KM, YH
alternative term: HCV
definition source: WEB: http://en.wikipedia.org/wiki/Hepatitis_C_virus
see also: NCIT: C14312

blood phosphate abnormal AE
type: Class
subclass of: blood phosphorus abnormal AE
definition: a blood phosphorus abnormal AE that shows an abnormal blood phosphate level
definition editor: EB
has_MedDRA_id: 10054823

blood albumin abnormal AE
type: Class
subclass of: hematology investigation result abnormal AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000178
definition: a hematology investigation result abnormal AE that results in an abnormal level of albumin in the blood
definition editor: EB
has_MedDRA_id: 10005800

blood carbon dioxide abnormal AE'
type: Class
subclass of: electrolyte blood test abnormal AE
definition: an electrolyte blood lab test abnormal AE that results in an abnormal level of sodium in the blood
definition editor: YH, MW

hypercapnia AE
type: Class
subclass of: blood carbon dioxide abnormal AE'
definition: a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally high
definition editor: DJ, SS, YH, MW
alternative term: CO2 retention AE
alternative term: hypercapnea AE
alternative term: hypercarbia AE
definition source: WEB: https://en.wikipedia.org/wiki/Hypercapnia
has_MedDRA_id: 10020591
see also: UMLS CUI: C0020440

blood glucose decreased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an decreased level of glucose in the blood
definition editor: EB, YH, MW
has_MedDRA_id: 10005555
see also: UMLS CUI: C0595883

blood glucose increased
type: Class
subclass of: PATO_0001018
definition: A physical quality that has an increased level of glucose in the blood
definition editor: EB, YH, MW
has_MedDRA_id: 10005557
see also: UMLS CUI: C0595877

acneiform rash AE
type: Class
subclass of: rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a rash AE that shows follicular eruptions characterized by papules and pustules resembling acne.
definition editor: YH, MW
alternative term: acneiform eruption AE
alternative term: rash acneiform AE
definition source: WEB: http://en.wikipedia.org/wiki/Acne_vulgaris
definition source: WEB: http://en.wikipedia.org/wiki/Acneiform_eruption
has_MedDRA_id: 10037847
comment: The term "acneiform", literally, refers to an appearance similar to acne. Acne vulgaris (or simply acne) is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring.
see also: CTCAE: E13694
see also: NCIt: C35277

papulopustular rash AE
type: Class
subclass of: rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: A rash AE that is characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back.
definition editor: YH
definition source: WEB: http://www.medaphile.com/medical-dictionary/papulopustular-rash
has_MedDRA_id: 10069138
comment: Unlike acne, papulopustular rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.
see also: CTCAE: E11491
see also: NCIt: C80119

cranial neuropathy AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0001785
subclass of: neuropathy AE
definition: an neuropathy AE that occurs when any of the twelve cranial nerves (nerves that exit from the brain directly) are damaged.
definition editor: MW, YH
definition source: WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
has_MedDRA_id: 10061096

auditory neuropathy AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000970
definition: a cranial neuropathy AE which shows an damage or abnormality to the nerve that carries signals from the inner ear to the brain and is responsible for hearing.
definition editor: MW, YH
definition source: WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy

cognitive disturbance AE
type: Class
subclass of: cognitive disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cognitive disorder AE that shows conspicuous changes in cognitive functions.
definition editor: MW, YH
has_MedDRA_id: 10009845
see also: CTCAE: E12617
see also: NCIt: C27101

focal neuropathy AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0002410
subclass of: neuropathy AE
definition: an neuropathy AE that is restricted to one nerve or group of nerves, or one area of the body
definition editor: MW, YH
definition source: WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy

thromboembolism AE
type: Class
subclass of: vascular disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a vascular disorder AE that form in a blood vessel a clot (thrombus) that breaks loose and is carried by the blood stream to plug another vessel.
definition editor: MW, YH
alternative term: thromboembolic event AE
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=25032
has_MedDRA_id: 10043565
see also: CTCAE: E13825

cardiovascular injury AE
type: Class
subclass of: injury AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0004535
definition: an injury AE that occurs in the cardiovascular system
definition editor: YH
has_MedDRA_id: 10007654
see also: UMLS CUI: C0560570

heart injury AE
type: Class
subclass of: cardiovascular injury AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0000948
definition: a cardiovascular injury AE that occurs in a heart.
definition editor: YH
has_MedDRA_id: 10061200
see also: UMLS CUI: C0018805

myocardial rupture AE
type: Class
subclass of: heart injury AE
subclass of: Restriction
  on property: occurs in
  some values from: UBERON_0002349
definition: a heart injury AE that shows a laceration or tearing of the myoardium, which is the muscular tissue of the heart.
definition editor: YH
definition source: WEB: https://en.wikipedia.org/wiki/Myocardial_rupture
has_MedDRA_id: 10028604
see also: UMLS CUI: C0018813

hypertensive cardiomyopathy AE
type: Class
subclass of: cardiomyopathy AE
definition: a cardiomyopathy AE that is characterized by a weekened heart caused by the effects of high blood pressure.
definition editor: YH
definition source: WEB: http://www.freemd.com/hypertensive-cardiomyopathy/overview.htm
has_MedDRA_id: 10058222
see also: UMLS CUI: C1144799

hypertrophic obstructive cardiomyopathy AE
type: Class
subclass of: hypertrophic cardiomyopathy AE
definition: A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy causes an obstruction of the outflow of blood from the left ventricle of the heart
definition editor: YH
alternative term: ASH
alternative term: HOCM
alternative term: IHSS
alternative term: asymmetric septal hypertrophy
alternative term: idiopathic hypertrophic subaortic stenosis
definition source: WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive
has_MedDRA_id: 10020204
see also: UMLS CUI: C0007194

hypertrophic non-obstructive cardiomyopathy AE
type: Class
subclass of: hypertrophic cardiomyopathy AE
definition: A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy does not cause an obstruction of the outflow of blood from the left ventricle of the heart
definition editor: YH
alternative term: Yamaguchi Hypertrophy
alternative term: Yamaguchi Syndrome
alternative term: apical hypertrophic cardiomyopathy
alternative term: idiopathic hypertrophic subaortic stenosis
alternative term: non-obstructive cardiomyopathy
definition source: WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy
definition source: WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive

cardiac function test abnormal AE
type: Class
subclass of: cardiovascular investigation result abnormal AE
definition: a cardiovascular investigation result abnormal AE that results in an abnormal result on a test used to evaluate heart function
definition editor: YH
definition source: WEB: http://www.drsinatra.com/heart-function-tests-to-assess-heart-disease-risk/
definition source: WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures
has_MedDRA_id: 10058479
see also: UMLS CUI: C0438177

multiple cardiac defects AE
type: Class
subclass of: cardiac disorder AE
definition: a cardiac disorder AE that results in multiple cardiac defects.
definition editor: YH
definition source: WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures
has_MedDRA_id: 10058479
see also: UMLS CUI: C0438177

device occlusion AE
type: Class
subclass of: medical device adverse event
definition: an injury and procedural complication AE that results in a blockage of a device.
definition editor: YH
has_MedDRA_id: 10064685
see also: UMLS CUI: C1608397

medical device adverse event
type: Class
subclass of: procedural complication AE
definition: a procedural complication AE that occurs after the usage of a medical device.
definition editor: YH
alternative term: device AE
alternative term: device adverse event

Grade 1 skin ulceration AE
type: Class
subclass of: skin ulceration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a skin ulceration AE that has a combined area of ulcers <1 cm and nonblanchable erythema of intact skin with associated warmth or edema
definition editor: MW, YH
definition source: WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
see also: CTCAE: E13731

Grade 2 skin ulceration AE
type: Class
subclass of: skin ulceration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
subclass of: Restriction
  on property: results in formation of
  some values from: Class
    intersection of: OAE_0004372
    intersection of: Restriction
      on property: has diameter in cm
      some values from: Datatype
        on datatype: decimal
definition: a skin ulceration AE that has a combined area of ulcers 1 - 2 cm and partial thickness skin loss involving skin or subcutaneous fat
definition editor: MW, YH
definition source: WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
see also: CTCAE: E13732

Grade 3 skin ulceration AE
type: Class
subclass of: skin ulceration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a skin ulceration AE that has a combined area of ulcers >2 cm and full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia
definition editor: MW, YH
definition source: WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
see also: CTCAE: E13733

Grade 4 skin ulceration AE
type: Class
subclass of: skin ulceration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a skin ulceration AE that has any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss
definition editor: MW, YH
definition source: WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
see also: CTCAE: E13734

Laryngopharyngeal dysesthesia AE
type: Class
subclass of: dysesthesia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: A dysesthesia AE that shows an uncomfortable persistent sensation in the area of the laryngopharynx.
definition editor: MW, YH
has_MedDRA_id: 10062667
see also: CTCAE: E13433
see also: NCIt: C78414

initial hospitalization AE
type: Class
subclass of: hospitalization AE
definition: a hospitalization AE that leads to an intial hospitalization.
definition editor: YH, JX
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm

prolonged hospitalization AE
type: Class
subclass of: hospitalization AE
definition: a hospitalization AE that leads to a prolonged hospitalization.
definition editor: YH, JX
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm

local AE
type: Class
subclass of: adverse event
definition: an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation.
definition editor: YH, JX
definition source: URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction

obsolete: injury or procedural complication AE
type: Class
subclass of: ObsoleteClass
definition: an adverse event that shows a result of injury or procedural complication.
definition editor: JX, YH
alternative term: injury and procedural complication AE
comment: 3/11/2019: This term became obsolete since the "or" structure is confusing, and injury AE and procedure complication AE are two different categories.

central nervous system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0001017
subclass of: nervous system AE
definition: a nervous system AE that occurs in the central nervous system
definition editor: JX, YH

meninges AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: UBERON_0010743
subclass of: central nervous system AE
definition: a nervous system AE that occurs in the area of meninges
definition editor: JX, YH
definition source: WEB: https://en.wikipedia.org/wiki/Meninges

meninges inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: AE occurs in
  some values from: UBERON_0010743
definition: an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
see also: MP: MP_0001847

delusions AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a mental disorder that has false personal beliefs held contrary to reality, despite contradictory evidence and common sense.
definition editor: MW, YH
has_MedDRA_id: 10012260
see also: CTCAE: E12904
see also: NCIt: C26741

laryngeal inflammation AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an inflammation AE that has an inflammation involving the larynx.
definition editor: MW, YH
has_MedDRA_id: 10065735
see also: CTCAE: E13411
see also: NCIt: C26811

testicular disorder AE
type: Class
subclass of: male reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a male reproductive system AE that has involvement of the testis.
definition editor: MW, YH
has_MedDRA_id: 10043306
see also: CTCAE: E13215
see also: NCIt: C26890

urinary frequency AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: an urinary system AE that has urination at short intervals.
definition editor: MW, YH
has_MedDRA_id: 10046539
see also: CTCAE: E13039
see also: NCIt: C26906

vaginal inflammation AE
type: Class
subclass of: OAE_0004306
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a reproduction system inflammation AE that has inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge.
definition editor: MW, YH
has_MedDRA_id: 10046916
see also: CTCAE: E13270
see also: NCIt: C26911

trigeminal nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cranial neuropathy AE that has involvement of the trigeminal nerve (fifth cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10060890
see also: CTCAE: E12841
see also: NCIt: C26952

accessory nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: cranial neuropathy AE that has involvement of the accessory nerve (eleventh cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10060929
see also: CTCAE: E12573
see also: NCIt: C26953

hypoglossal nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cranial neuropathy AE that has involvement of the hypoglossal nerve (twelfth cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10061212
see also: CTCAE: E12692
see also: NCIt: C26954

pharyngeal hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the pharynx.
definition editor: MW, YH
has_MedDRA_id: 10055315
see also: CTCAE: E13460
see also: NCIt: C26986

brachial plexopathy AE
type: Class
subclass of: distal neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a distal neuropathy AE that has regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.
definition editor: MW, YH
has_MedDRA_id: 10065417
see also: CTCAE: E12601
see also: NCIt: C27194

acoustic nerve disorder NOS AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cranial neuropathy AE that has involvement of the acoustic nerve (eighth cranial nerve)
definition editor: MW, YH
has_MedDRA_id: 10000521
see also: CTCAE: E12577
see also: NCIt: C27207

olfactory nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
definition: a cranial neuropathy AE that has involvement of the olfactory nerve (first cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10056388
see also: CTCAE: E12755
see also: NCIt: C27210

glossopharyngeal nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cranial neuropathy AE that has involvement of the glossopharyngeal nerve (ninth cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10061185
see also: CTCAE: E12672
see also: NCIt: C27211

vagus nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cranial neuropathy AE that has involvement of the vagus nerve (tenth cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10061403
see also: CTCAE: E12845
see also: NCIt: C27591

abducens nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cranial neuropathy AE that has involvement of the abducens nerve (sixth cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10053662
see also: CTCAE: E12569
see also: NCIt: C27593

facial nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cranial neuropathy AE that has involvement of the facial nerve (seventh cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10061457
see also: CTCAE: E12668
see also: NCIt: C27594

oculomotor nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cranial neuropathy AE that has involvement of the oculomotor nerve (third cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10053661
see also: CTCAE: E12751
see also: NCIt: C27598

dysesthesia AE
type: Class
subclass of: sensory neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sensory neuropathy AE that has distortion of sensory perception, resulting in an abnormal and unpleasant sensation.
definition editor: MW, YH
has_MedDRA_id: 10062872
see also: CTCAE: E12639
see also: NCIt: C28246

dyspareunia AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has painful or difficult coitus.
definition editor: MW, YH
has_MedDRA_id: 10013941
see also: CTCAE: E13081
see also: NCIt: C2997

exostosis AE
type: Class
subclass of: bone AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a bone disorder AE that has non-neoplastic overgrowth of bone.
definition editor: MW, YH
has_MedDRA_id: 10015688
see also: CTCAE: E12404
see also: NCIt: C3029

gynecomastia AE
type: Class
subclass of: endocrine system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an endocrine system AE that has excessive development of the breasts in males.
definition editor: MW, YH
has_MedDRA_id: 10018801
see also: CTCAE: E13115
see also: NCIt: C3073

hydrocephalus AE
type: Class
subclass of: brain edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a brain edema AE that has an abnormal increase of cerebrospinal fluid in the ventricles of the brain.
definition editor: MW, YH
has_MedDRA_id: 10020508
see also: CTCAE: E12682
see also: NCIt: C3111

lymphedema AE
type: Class
subclass of: edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an edema AE that has excessive fluid collection in tissues that causes swelling.
definition editor: MW, YH
has_MedDRA_id: 10025233
see also: CTCAE: E13802
see also: NCIt: C3207

menopause AE
type: Class
subclass of: menstrual disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a menstrual disorder AE that has the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age.
definition editor: MW, YH
has_MedDRA_id: 10027308
see also: CTCAE: E13750
see also: NCIt: C3231

obesity AE
type: Class
subclass of: physical examination result abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a physical examination result abnormal AE that is having a high amount of body fat.
definition editor: MW, YH
has_MedDRA_id: 10029883
see also: CTCAE: E12361
see also: NCIt: C3283

adult respiratory distress syndrome AE
type: Class
subclass of: lung inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a lung inflammation AE that has progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery.
definition editor: MW, YH
has_MedDRA_id: 10001409
see also: CTCAE: E13299
see also: NCIt: C3353

Superior vena cava syndrome AE
type: Class
subclass of: cardiovascular AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cardiovascular AE that has obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.
definition editor: MW, YH
see also: CTCAE: E13819
see also: NCIt: C3396

dysmenorrhea AE
type: Class
subclass of: menstrual disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a menstrual disorder AE that has abnormally painful abdominal cramps during menses.
definition editor: MW, YH
has_MedDRA_id: 10013934
see also: CTCAE: E13077
see also: NCIt: C34559

euphoria AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a behavior and neurological AE that has an exaggerated feeling of well-being which is disproportionate to events and stimuli.
definition editor: MW, YH
has_MedDRA_id: 10015533
see also: CTCAE: E12915
see also: NCIt: C34598

flank pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip.
definition editor: MW, YH
has_MedDRA_id: 10016750
has_exact_synonym: flank pain
see also: CTCAE: E12414
see also: NCIt: C34615

glucose intolerance AE
type: Class
subclass of: metabolic disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a metabolic disorder AE that has an inability to properly metabolize glucose.
definition editor: MW, YH
has_MedDRA_id: 10052426
see also: CTCAE: E12264
see also: NCIt: C34646

hemoglobinuria AE
type: Class
subclass of: urine abnormality AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a urine abnormality AE that has laboratory test results that indicate the presence of free hemoglobin in the urine.
definition editor: MW, YH
alternative term: haemoglobinuria AE
has_MedDRA_id: 10018906
has_MedDRA_id: 10019489
see also: CTCAE: E13006
see also: NCIt: C34677

hypohidrosis AE
type: Class
subclass of: sweating AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a sweating AE that has reduced sweating.
definition editor: MW, YH
has_MedDRA_id: 10021013
see also: CTCAE: E13652
see also: NCIt: C34718

kyphosis AE
type: Class
subclass of: bone AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a bone disorder AE that has an abnormal increase in the curvature of the thoracic portion of the spine.
definition editor: MW, YH
has_MedDRA_id: 10023509
see also: CTCAE: E12447
see also: NCIt: C34754

lordosis AE
type: Class
subclass of: bone AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a bone disorder AE that has an abnormal increase in the curvature of the lumbar portion of the spine.
definition editor: MW, YH
has_MedDRA_id: 10024842
see also: CTCAE: E12451
see also: NCIt: C34787

oligospermia AE
type: Class
subclass of: male reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a male reproductive system AE that has a decrease in the number of spermatozoa in the semen.
definition editor: MW, YH
has_MedDRA_id: 10030300
see also: CTCAE: E13141
see also: NCIt: C34860

avascular necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.
definition editor: MW, YH
has_MedDRA_id: 10066480
see also: CTCAE: E12382
see also: NCIt: C34880

bullous dermatitis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has inflammation of the skin characterized by the presence of bullae which are filled with fluid.
definition editor: MW, YH
has_MedDRA_id: 10006556
see also: CTCAE: E13617
see also: NCIt: C35149

dysphasia AE
type: Class
subclass of: speech disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a speech disorder AE that has impairment of verbal communication skills, often resulting from brain damage.
definition editor: MW, YH
has_MedDRA_id: 10013951
see also: CTCAE: E12646
see also: NCIt: C35546

vaginal stricture AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G5
definition: a female reproductive system AE that has a narrowing of the vaginal canal.
definition editor: MW, YH
has_MedDRA_id: 10053496
see also: CTCAE: E13290
see also: NCIt: C36064

alkalosis AE
type: Class
subclass of: metabolism, endocrine or exocrine system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a metabolism, endocrine, and exocrine system AE that has abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.
definition editor: MW, YH
has_MedDRA_id: 10001680
see also: CTCAE: E12247
see also: NCIt: C37909

Hiccups AE
type: Class
subclass of: gastrointestinal disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a gastrointestinal disorder AE that has repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.
definition editor: MW, YH
has_MedDRA_id: 10020039
see also: CTCAE: E13380
see also: NCIt: C37966

proteinuria AE
type: Class
subclass of: urine abnormality AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an urine abnormality AE that has laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.
definition editor: MW, YH
has_MedDRA_id: 10037032
see also: CTCAE: E13008
see also: NCIt: C38012

erythroderma AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.
definition editor: MW, YH
has_MedDRA_id: 10015277
see also: CTCAE: E13633
see also: NCIt: C39646

pyramidal tract syndrome AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a syndrome AE that has dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination.
definition editor: MW, YH
has_MedDRA_id: 10063636
see also: CTCAE: E12780
see also: NCIt: C43245

edema cerebral AE
type: Class
subclass of: brain edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a brain edema AE that has swelling due to an excessive accumulation of fluid in the brain.
definition editor: MW, YH
has_MedDRA_id: 10014217
see also: CTCAE: E12650
see also: NCIt: C4909

treatment related secondary malignancy AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a tumor AE that has development of a malignancy most probably as a result of treatment for a previously existing malignancy.
definition editor: MW, YH
has_MedDRA_id: 10049737
see also: CTCAE: E12561
see also: NCIt: C4969

intracranial hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the cranium.
definition editor: MW, YH
has_MedDRA_id: 10022763
see also: CTCAE: E12696
see also: NCIt: C50438

fetal death AE
type: Class
subclass of: death AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G5
definition: a death AE that has death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation.
definition editor: MW, YH
has_MedDRA_id: 10016479
see also: CTCAE: E12855
see also: NCIt: C50620

transient ischemic attacks AE
type: Class
subclass of: ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a ischemia AEE that has a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.
definition editor: MW, YH
has_MedDRA_id: 10044391
see also: CTCAE: E12834
see also: NCIt: C50781

vaginal discharge AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: afemale reproductive system AE that has vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years.
definition editor: MW, YH
has_MedDRA_id: 10046901
see also: CTCAE: E13251
see also: NCIt: C50795

vasovagal reaction AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a sensory capability AE that has a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve.
definition editor: MW, YH
has_MedDRA_id: 10047166
see also: CTCAE: E12851
see also: NCIt: C50798

premature delivery AE
type: Class
subclass of: pregnancy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: apregnancy AE that has delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.
definition editor: MW, YH
Chinese translation: 早产
has_MedDRA_id: 10036595
see also: CTCAE: E12867
see also: NCIt: C50917

mania AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood.
definition editor: MW, YH
has_MedDRA_id: 10026749
see also: CTCAE: E12936
see also: NCIt: C61374

hirsutism AE
type: Class
subclass of: hair growth abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a hair growth abnormal AE that has the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen)
definition editor: MW, YH
has_MedDRA_id: 10020112
see also: CTCAE: E13642
see also: NCIt: C61444

osteonecrosis of jaw AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the bone of the mandible.
definition editor: MW, YH
has_MedDRA_id: 10064658
see also: CTCAE: E12502
see also: NCIt: C63924

abdominal soft tissue necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the soft tissues of the abdominal wall.
definition editor: MW, YH
has_MedDRA_id: 10065775
see also: CTCAE: E12369
see also: NCIt: C78165

alcohol intolerance AE
type: Class
subclass of: metabolic disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a metabolic disorder AE that has an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches.
definition editor: MW, YH
has_MedDRA_id: 10001598
see also: CTCAE: E12242
see also: NCIt: C78167

anorgasmia AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a psychiatric disorder AE that has an inability to achieve orgasm.
definition editor: MW, YH
has_MedDRA_id: 10002652
see also: CTCAE: E12880
see also: NCIt: C78177

bladder perforation AE
type: Class
subclass of: OAE_0004457
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an urinary system AE that has a rupture in the bladder wall.
definition editor: MW, YH
has_MedDRA_id: 10063575
see also: CTCAE: E12979
see also: NCIt: C78208

bladder spasm AE
type: Class
subclass of: OAE_0004457
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an urinary system AE that has a sudden and involuntary contraction of the bladder wall.
definition editor: MW, YH
has_MedDRA_id: 10048994
see also: CTCAE: E12984
see also: NCIt: C78210

bronchopulmonary hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that is bleeding from the bronchial wall and/or lung parenchyma.
definition editor: MW, YH
has_MedDRA_id: 10065746
see also: CTCAE: E13346
see also: NCIt: C78224

bronchial obstruction AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has blockage of a bronchus passage, most often by bronchial secretions and exudates.
definition editor: MW, YH
has_MedDRA_id: 10006440
see also: CTCAE: E13328
see also: NCIt: C78225

bronchial stricture AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has a narrowing of the bronchial tube.
definition editor: MW, YH
has_MedDRA_id: 10063524
see also: CTCAE: E13334
see also: NCIt: C78226

central nervous system necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the brain and/or spinal cord.
definition editor: MW, YH
has_MedDRA_id: 10065784
see also: CTCAE: E12605
see also: NCIt: C78236

chest wall pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort sensation in the chest wall region.
definition editor: MW, YH
has_MedDRA_id: 10008496
see also: CTCAE: E12400
see also: NCIt: C78238

cystitis noninfective AE
type: Class
subclass of: cystitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a cystitis AE that has inflammation of the bladder which is not caused by an infection of the urinary tract.
definition editor: MW, YH
has_MedDRA_id: 10063057
see also: CTCAE: E12994
see also: NCIt: C78250

delayed orgasm AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a psychiatric disorder AE that has sexual dysfunction characterized by a delay in climax.
definition editor: MW, YH
has_MedDRA_id: 10057066
see also: CTCAE: E12895
see also: NCIt: C78252

ejaculation disorder AE
type: Class
subclass of: male reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a male reproductive system AE that has problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.
definition editor: MW, YH
has_MedDRA_id: 10014326
see also: CTCAE: E13085
see also: NCIt: C78264

facial muscle weakness AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscular weakness AE that has a reduction in the strength of the facial muscles.
definition editor: MW, YH
has_MedDRA_id: 10051272
see also: CTCAE: E12664
see also: NCIt: C78290

fallopian tube obstruction AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a female reproductive system AE that has blockage of the normal flow of the contents in the fallopian tube.
definition editor: MW, YH
has_MedDRA_id: 10065789
see also: CTCAE: E13092
see also: NCIt: C78293

fallopian tube stenosis AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a female reproductive system AE that has a narrowing of the fallopian tube lumen.
definition editor: MW, YH
has_MedDRA_id: 10065791
see also: CTCAE: E13096
see also: NCIt: C78295

fat atrophy AE
type: Class
subclass of: connective tissue disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a connective tissue disorder AE that has shrinking of adipose tissue.
definition editor: MW, YH
has_MedDRA_id: 10016241
see also: CTCAE: E13638
see also: NCIt: C78297

female genital tract fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between a female reproductive system organ and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10061149
see also: CTCAE: E13102
see also: NCIt: C78298

feminization acquired AE
type: Class
subclass of: endocrine system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: an endocrine system AE that has the development of secondary female sex characteristics in males due to extrinsic factors.
definition editor: MW, YH
has_MedDRA_id: 10054382
see also: CTCAE: E13108
see also: NCIt: C78299

fibrosis deep connective tissue AE
type: Class
subclass of: connective tissue disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a connective tissue disorder AE that has fibrotic degeneration of the deep connective tissues.
definition editor: MW, YH
has_MedDRA_id: 10065799
see also: CTCAE: E12408
see also: NCIt: C78301

generalized muscle weakness AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscular weakness AE that has a reduction in the strength of muscles in multiple anatomic sites.
definition editor: MW, YH
has_MedDRA_id: 10062572
see also: CTCAE: E12418
see also: NCIt: C78323

growth suppression AE
type: Class
subclass of: musculoskeletal or connective tissue AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a musculoskeletal and connective tissue AE that has stature that is smaller than normal as expected for age.
definition editor: MW, YH
has_MedDRA_id: 10018761
see also: CTCAE: E12422
see also: NCIt: C78328

head soft tissue necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the soft tissues of the head.
definition editor: MW, YH
has_MedDRA_id: 10065779
see also: CTCAE: E12426
see also: NCIt: C78331

hematosalpinx AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a female reproductive system AE that has the presence of blood in a fallopian tube.
definition editor: MW, YH
has_MedDRA_id: 10060602
see also: CTCAE: E13119
see also: NCIt: C78332

hypersomnia AE
type: Class
subclass of: sleep disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sleep disorder AE that has characterized by excessive sleepiness during the daytime.
definition editor: MW, YH
has_MedDRA_id: 10020765
see also: CTCAE: E12688
see also: NCIt: C78346

iron overload AE
type: Class
subclass of: homeostasis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a homeostasis AE that has accumulation of iron in the tissues.
definition editor: MW, YH
has_MedDRA_id: 10065973
see also: CTCAE: E12350
see also: NCIt: C78393

ischemia cerebrovascular AE
type: Class
subclass of: ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: an ischemia AE that has a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.
definition editor: MW, YH
has_MedDRA_id: 10023030
see also: CTCAE: E12702
see also: NCIt: C78394

IVth nerve disorder AE
type: Class
subclass of: cranial neuropathy AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a cranial neuropathy AE that has involvement of the trochlear nerve (fourth cranial nerve).
definition editor: MW, YH
has_MedDRA_id: 10065836
see also: CTCAE: E12705
see also: NCIt: C78395

joint range of motion decreased cervical spine AE
type: Class
subclass of: joint disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a joint disorder AE that has a decrease in flexibility of a cervical spine joint.
definition editor: MW, YH
has_MedDRA_id: 10065796
see also: CTCAE: E12439
see also: NCIt: C78404

joint range of motion decreased lumbar spine AE
type: Class
subclass of: joint disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a joint disorder AE that has a decrease in flexibility of a lumbar spine joint.
definition editor: MW, YH
has_MedDRA_id: 10065800
see also: CTCAE: E12443
see also: NCIt: C78405

laryngeal fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between the larynx and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10065786
see also: CTCAE: E13399
see also: NCIt: C78410

laryngeal hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the larynx.
definition editor: MW, YH
has_MedDRA_id: 10065759
see also: CTCAE: E13405
see also: NCIt: C78411

laryngeal mucositis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has an inflammation involving the mucous membrane of the larynx.
definition editor: MW, YH
has_MedDRA_id: 10065880
see also: CTCAE: E13415
see also: NCIt: C78412

laryngeal obstruction AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has blockage of the laryngeal airway.
definition editor: MW, YH
has_MedDRA_id: 10059639
see also: CTCAE: E13421
see also: NCIt: C78413

libido decreased AE
type: Class
subclass of: libido disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a libido disorder AE that has a decrease in sexual desire.
definition editor: MW, YH
has_MedDRA_id: 10024419
see also: CTCAE: E12929
see also: NCIt: C78432

libido increased AE
type: Class
subclass of: libido disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a libido disorder AE that has an increase in sexual desire.
definition editor: MW, YH
has_MedDRA_id: 10024421
see also: CTCAE: E12932
see also: NCIt: C78433

lipohypertrophy AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a skin AE that has hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.
definition editor: MW, YH
has_MedDRA_id: 10062315
see also: CTCAE: E13657
see also: NCIt: C78436

lymph leakage AE
type: Class
subclass of: immune system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an immune system AE that has the loss of lymph fluid into the surrounding tissue or body cavity.
definition editor: MW, YH
has_MedDRA_id: 10065773
see also: CTCAE: E13797
see also: NCIt: C78439

lymphocele AE
type: Class
subclass of: immune system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an immune system AE that has a cystic lesion containing lymph.
definition editor: MW, YH
has_MedDRA_id: 10048642
see also: CTCAE: E13806
see also: NCIt: C78442

mediastinal hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the mediastinum.
definition editor: MW, YH
has_MedDRA_id: 10056356
see also: CTCAE: E13444
see also: NCIt: C78443

movements involuntary AE
type: Class
subclass of: movement disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a movement disorder AE that has uncontrolled and purposeless movements.
definition editor: MW, YH
has_MedDRA_id: 10028041
see also: CTCAE: E12728
see also: NCIt: C78453

muscle weakness left-sided AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscular weakness AE that has a reduction in the strength of the muscles on the left side of the body.
definition editor: MW, YH
has_MedDRA_id: 10065780
see also: CTCAE: E12455
see also: NCIt: C78455

muscle weakness lower limb AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscular weakness AE that has a reduction in the strength of the lower limb muscles.
definition editor: MW, YH
has_MedDRA_id: 10065776
see also: CTCAE: E12459
see also: NCIt: C78456

muscle weakness right-sided AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscular weakness AE that has a reduction in the strength of the muscles on the right side of the body.
definition editor: MW, YH
has_MedDRA_id: 10065794
see also: CTCAE: E12463
see also: NCIt: C78457

muscle weakness trunk AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscular weakness AE that has a reduction in the strength of the trunk muscles.
definition editor: MW, YH
has_MedDRA_id: 10065795
see also: CTCAE: E12467
see also: NCIt: C78458

muscle weakness upper limb AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a muscular weakness AE that has a reduction in the strength of the upper limb muscles.
definition editor: MW, YH
has_MedDRA_id: 10065895
see also: CTCAE: E12471
see also: NCIt: C78459

musculoskeletal deformity AE
type: Class
subclass of: musculoskeletal or connective tissue AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a musculoskeletal and connective tissue AE that has a malformation of the musculoskeletal system.
definition editor: MW, YH
has_MedDRA_id: 10065783
see also: CTCAE: E12481
see also: NCIt: C78488

nail discoloration AE
type: Class
subclass of: nail AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a nail AE that has a change in the color of the nail plate.
definition editor: MW, YH
has_MedDRA_id: 10028691
see also: CTCAE: E13661
see also: NCIt: C78492

nail loss AE
type: Class
subclass of: nail AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a nail AE that has loss of all or a portion of the nail.
definition editor: MW, YH
has_MedDRA_id: 10049281
see also: CTCAE: E13663
see also: NCIt: C78494

nail ridging AE
type: Class
subclass of: nail AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a nail AE that has vertical or horizontal ridges on the nails.
definition editor: MW, YH
has_MedDRA_id: 10062283
see also: CTCAE: E13666
see also: NCIt: C78499

neck soft tissue necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the soft tissues of the neck.
definition editor: MW, YH
has_MedDRA_id: 10065781
see also: CTCAE: E12497
see also: NCIt: C78502

nipple deformity AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a female reproductive system AE that has a malformation of the nipple.
definition editor: MW, YH
has_MedDRA_id: 10065823
see also: CTCAE: E13138
see also: NCIt: C78503

ovarian hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the ovary.
definition editor: MW, YH
has_MedDRA_id: 10065763
see also: CTCAE: E13145
see also: NCIt: C78511

ovarian rupture AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a female reproductive system AE that is tearing or disruption of the ovarian tissue.
definition editor: MW, YH
has_MedDRA_id: 10033279
see also: CTCAE: E13151
see also: NCIt: C78513

ovulation pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.
definition editor: MW, YH
has_MedDRA_id: 10033314
see also: CTCAE: E13157
see also: NCIt: C78514

pelvic floor muscle weakness AE
type: Class
subclass of: muscular weakness AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a muscular weakness AE that has a reduction in the strength of the muscles of the pelvic floor.
definition editor: MW, YH
has_MedDRA_id: 10064026
see also: CTCAE: E13161
see also: NCIt: C78524

pelvic soft tissue necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the soft tissues of the pelvis.
definition editor: MW, YH
has_MedDRA_id: 10065793
see also: CTCAE: E12516
see also: NCIt: C78525

penile pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort sensation in the penis.
definition editor: MW, YH
has_MedDRA_id: 10034310
see also: CTCAE: E13171
see also: NCIt: C78527

personality change AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has a conspicuous change in a person's behavior and thinking.
definition editor: MW, YH
has_MedDRA_id: 10034719
see also: CTCAE: E12942
see also: NCIt: C78548

pharyngeal fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between the pharynx and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10034825
see also: CTCAE: E13454
see also: NCIt: C78551

pharyngeal mucositis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has an inflammation involving the mucous membrane of the pharynx.
definition editor: MW, YH
has_MedDRA_id: 10065881
see also: CTCAE: E13466
see also: NCIt: C78553

pharyngeal necrosis AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the pharynx.
definition editor: MW, YH
has_MedDRA_id: 10065706
see also: CTCAE: E13472
see also: NCIt: C78554

pharyngeal stenosis AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has a narrowing of the pharyngeal airway.
definition editor: MW, YH
has_MedDRA_id: 10050028
see also: CTCAE: E13476
see also: NCIt: C78555

prostatic hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the prostate gland.
definition editor: MW, YH
has_MedDRA_id: 10055325
see also: CTCAE: E13181
see also: NCIt: C78572

prostatic obstruction AE
type: Class
subclass of: prostatic disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a prostatic disorder AE that has compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder).
definition editor: MW, YH
has_MedDRA_id: 10055026
see also: CTCAE: E13187
see also: NCIt: C78573

prostatic pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has a sensation of marked discomfort in the prostate gland.
definition editor: MW, YH
has_MedDRA_id: 10036968
see also: CTCAE: E13191
see also: NCIt: C78574

psychosis AE
type: Class
subclass of: psychiatric disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a psychiatric disorder AE that has personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor.
definition editor: MW, YH
has_MedDRA_id: 10037234
see also: CTCAE: E12954
see also: NCIt: C78576

pulmonary fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between the lung and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10065873
see also: CTCAE: E13533
see also: NCIt: C78577

radiculitis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root.
definition editor: MW, YH
has_MedDRA_id: 10061928
see also: CTCAE: E12786
see also: NCIt: C78581

recurrent laryngeal nerve palsy AE
type: Class
subclass of: OAE_0004344
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a recurrent alsy AE that occurs at the laryngeal nerve.
definition editor: MW, YH
has_MedDRA_id: 10038130
see also: CTCAE: E12792
see also: NCIt: C78592

renal colic AE
type: Class
subclass of: renal calculus AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a renal calculus AE that has paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones.
definition editor: MW, YH
has_MedDRA_id: 10038419
see also: CTCAE: E13024
see also: NCIt: C78593

renal hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the kidney.
definition editor: MW, YH
has_MedDRA_id: 10038463
see also: CTCAE: E13028
see also: NCIt: C78594

retinoic acid syndrome AE
type: Class
subclass of: syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a syndrome AE that has weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid.
definition editor: MW, YH
has_MedDRA_id: 10038921
see also: CTCAE: E13554
see also: NCIt: C78597

scoliosis AE
type: Class
subclass of: bone AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a bone disorder AE that has a malformed, lateral curvature of the spine.
definition editor: MW, YH
has_MedDRA_id: 10039722
see also: CTCAE: E12521
see also: NCIt: C78603

scrotal pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort sensation in the scrotal area.
definition editor: MW, YH
has_MedDRA_id: 10039757
see also: CTCAE: E13201
see also: NCIt: C78607

sinus pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.
definition editor: MW, YH
has_MedDRA_id: 10040747
see also: CTCAE: E12810
see also: NCIt: C78609

skin induration AE
type: Class
subclass of: induration AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an induration AE that has an area of hardness in the skin.
definition editor: MW, YH
has_MedDRA_id: 10051837
see also: CTCAE: E13724
see also: NCIt: C78611

soft tissue necrosis lower limb AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the soft tissues of the lower extremity.
definition editor: MW, YH
has_MedDRA_id: 10065777
see also: CTCAE: E12525
see also: NCIt: C78620

soft tissue necrosis upper limb AE
type: Class
subclass of: necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a necrosis AE that has a necrotic process occurring in the soft tissues of the upper extremity.
definition editor: MW, YH
has_MedDRA_id: 10065778
see also: CTCAE: E12530
see also: NCIt: C78621

spermatic cord hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the spermatic cord.
definition editor: MW, YH
has_MedDRA_id: 10065762
see also: CTCAE: E13205
see also: NCIt: C78623

spermatic cord obstruction AE
type: Class
subclass of: male reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a male reproductive system AE that has blockage of the normal flow of the contents of the spermatic cord.
definition editor: MW, YH
has_MedDRA_id: 10065805
see also: CTCAE: E13211
see also: NCIt: C78624

superficial soft tissue fibrosis AE
type: Class
subclass of: connective tissue disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a connective tissue disorder AE that has fibrotic degeneration of the superficial soft tissues.
definition editor: MW, YH
has_MedDRA_id: 10065798
see also: CTCAE: E12535
see also: NCIt: C78633

testicular hemorrhage AE
type: Class
subclass of: hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a hemorrhage AE that has bleeding from the testis.
definition editor: MW, YH
has_MedDRA_id: 10055347
see also: CTCAE: E13221
see also: NCIt: C78635

testicular pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has a sensation of marked discomfort in the testis.
definition editor: MW, YH
has_MedDRA_id: 10043345
see also: CTCAE: E13227
see also: NCIt: C78636

tracheal fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that hasan abnormal communication between the trachea and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10065787
see also: CTCAE: E13583
see also: NCIt: C78641

tracheal mucositis AE
type: Class
subclass of: inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an inflammation AE that has an inflammation involving the mucous membrane of the trachea.
definition editor: MW, YH
has_MedDRA_id: 10065900
see also: CTCAE: E13589
see also: NCIt: C78644

tracheal stenosis AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has a narrowing of the trachea.
definition editor: MW, YH
has_MedDRA_id: 10050816
see also: CTCAE: E13595
see also: NCIt: C78646

tumor pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis.
definition editor: MW, YH
has_MedDRA_id: 10045158
see also: CTCAE: E12565
see also: NCIt: C78656

unequal limb length AE
type: Class
subclass of: musculoskeletal or connective tissue AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a musculoskeletal and connective tissue AE that hasa discrepancy between the lengths of the lower or upper extremities.
definition editor: MW, YH
has_MedDRA_id: 10065738
see also: CTCAE: E12545
see also: NCIt: C78657

urine discoloration AE
type: Class
subclass of: urine abnormality AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: an urine abnormality AE that has a change in the color of the urine.
definition editor: MW, YH
has_MedDRA_id: 10046628
see also: CTCAE: E13065
see also: NCIt: C78678

uterine fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between the uterus and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10065811
see also: CTCAE: E13231
see also: NCIt: C78685

uterine obstruction AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: an urinary system AE that has blockage of the uterine outlet.
definition editor: MW, YH
has_MedDRA_id: 10065928
see also: CTCAE: E13243
see also: NCIt: C78693

uterine pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has a sensation of marked discomfort in the uterus.
definition editor: MW, YH
has_MedDRA_id: 10046809
see also: CTCAE: E13247
see also: NCIt: C78694

vaginal dryness AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a female reproductive system AE that has an uncomfortable feeling of itching and burning in the vagina.
definition editor: MW, YH
has_MedDRA_id: 10046904
see also: CTCAE: E13254
see also: NCIt: C78699

vaginal obstruction AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a female reproductive system AE that has blockage of vaginal canal.
definition editor: MW, YH
has_MedDRA_id: 10065817
see also: CTCAE: E13276
see also: NCIt: C78700

vaginal pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has a sensation of marked discomfort in the vagina.
definition editor: MW, YH
has_MedDRA_id: 10046937
see also: CTCAE: E13280
see also: NCIt: C78701

vaginal perforation AE
type: Class
subclass of: female reproductive system AE
definition: a female reproductive system AE that has a rupture in the vaginal wall.
definition editor: MW, YH
has_MedDRA_id: 10065818
see also: CTCAE: E13284
see also: NCIt: C78702

vaginismus AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a female reproductive system AE that hasinvoluntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse.
definition editor: MW, YH
has_MedDRA_id: 10046947
see also: CTCAE: E13295
see also: NCIt: C78703

visceral arterial ischemia AE
type: Class
subclass of: ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an ischemia AE that has a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery.
definition editor: MW, YH
has_MedDRA_id: 10054692
see also: CTCAE: E13843
see also: NCIt: C78712

body odor AE
type: Class
subclass of: skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a skin AE that has an abnormal body smell resulting from the growth of bacteria on the body.
definition editor: MW, YH
has_MedDRA_id: 10005901
see also: CTCAE: E13614
see also: NCIt: C79542

bronchial fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between the bronchus and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10006437
see also: CTCAE: E13322
see also: NCIt: C79543

extrapyramidal disorder AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a nervous system AE that has an abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness.
definition editor: MW, YH
has_MedDRA_id: 10015832
see also: CTCAE: E12658
see also: NCIt: C79593

hypertrichosis AE
type: Class
subclass of: hair growth abnormal AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a hair growth abnormal AE that has hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race.
definition editor: MW, YH
has_MedDRA_id: 10020864
see also: CTCAE: E13649
see also: NCIt: C79597

lactation disorder AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
definition: a female reproductive system AE that has disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males.
definition editor: MW, YH
has_MedDRA_id: 10061261
see also: CTCAE: E13129
see also: NCIt: C79606

laryngeal stenosis AE
type: Class
subclass of: respiratory system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a respiratory system AE that has a narrowing of the laryngeal airway.
definition editor: MW, YH
has_MedDRA_id: 10023862
see also: CTCAE: E13427
see also: NCIt: C79608

meningismus AE
type: Class
subclass of: nervous system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a nervous system AE that has neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges.
definition editor: MW, YH
has_MedDRA_id: 10027198
see also: CTCAE: E12722
see also: NCIt: C79694

phantom pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.
definition editor: MW, YH
has_MedDRA_id: 10056238
see also: CTCAE: E12774
see also: NCIt: C79703

scalp pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort sensation in the skin covering the top and the back of the head.
definition editor: MW, YH
has_MedDRA_id: 10049120
see also: CTCAE: E13704
see also: NCIt: C79716

unintended pregnancy AE
type: Class
subclass of: pregnancy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a pregnancy AE that has an unexpected pregnancy at the time of conception.
definition editor: MW, YH
has_MedDRA_id: 10045542
see also: CTCAE: E12872
see also: NCIt: C79801

urinary tract obstruction AE
type: Class
subclass of: OAE_0004456
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a urinary tract disoder AE that has blockage of the normal flow of contents of the urinary tract.
definition editor: MW, YH
has_MedDRA_id: 10061574
see also: CTCAE: E13052
see also: NCIt: C79805

vaginal fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between the vagina and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10065813
see also: CTCAE: E13258
see also: NCIt: C79847

urinary fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between any part of the urinary system and another organ or anatomic site.
definition editor: MW, YH
has_MedDRA_id: 10065368
see also: CTCAE: E13034
see also: NCIt: C79850

azoospermia AE
type: Class
subclass of: male reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a male reproductive system AE that has laboratory test results that indicate complete absence of spermatozoa in the semen.
definition editor: MW, YH
has_MedDRA_id: 10003883
see also: CTCAE: E13067
see also: NCIt: C80076

chronic kidney disease AE
type: Class
subclass of: renal failure AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a renal failure AE that has gradual and usually permanent loss of kidney function resulting in renal failure.
definition editor: MW, YH
has_MedDRA_id: 10064848
see also: CTCAE: E12988
see also: NCIt: C80078

concentration impairment AE
type: Class
subclass of: behavioral and neurological AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a behavior and neurological AE that has a deterioration in the ability to concentrate.
definition editor: MW, YH
has_MedDRA_id: 10010250
see also: CTCAE: E12621
see also: NCIt: C80081

fetal growth retardation AE
type: Class
subclass of: fetal disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
definition: a fetal disorder AE that has inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight.
definition editor: MW, YH
has_MedDRA_id: 10054746
see also: CTCAE: E12857
see also: NCIt: C80083

premature menopause AE
type: Class
subclass of: menstrual disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a menstrual disorder AE that has ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive.
definition editor: MW, YH
has_MedDRA_id: 10036601
see also: CTCAE: E13179
see also: NCIt: C80099

leukemia secondary to oncology chemotherapy AE
type: Class
subclass of: tumor AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G4
    union of: AE severity G5
definition: a tumor AE that has leukemia arising as a result of the mutagenic effect of chemotherapy agents.
definition editor: MW, YH
has_MedDRA_id: 10048293
see also: CTCAE: E12549
see also: NCIt: C80691

bronchopleural fistula AE
type: Class
subclass of: fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a fistula AE that has an abnormal communication between a bronchus and the pleural cavity.
definition editor: MW, YH
has_MedDRA_id: 10053481
see also: CTCAE: E13340
see also: NCIt: C80694

urinary tract pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has a sensation of marked discomfort in the urinary tract.
definition editor: MW, YH
has_MedDRA_id: 10062225
see also: CTCAE: E13058
see also: NCIt: C83493

breast atrophy AE
type: Class
subclass of: female reproductive system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a female reproductive system AE that has underdevelopment of the breast.
definition editor: MW, YH
has_MedDRA_id: 10006179
see also: CTCAE: E13069
see also: NCIt: C83494

medical procedure
type: Class
subclass of: medical intervention
definition: a medical intervention that refers to any series of pre-defined steps that should be followed to achieve a desired result.
definition editor: YH, SS
definition source: WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm

incision site AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: incision site
subclass of: medical intervention site AE
subclass of: local AE
definition: an AE that occurs in an incision site.
definition editor: YH, SS

incision site
type: Class
subclass of: medical intervention site
definition: a medical intervention site that is used for incision for a surgery.
definition editor: YH, SS

Grade 1 lymphedema AE
type: Class
subclass of: lymphedema AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hymphedema AE that has trace thickening or faint discoloration
definition editor: YH, MW
see also: CTCAE: E13803

Grade 2 lymphedema AE
type: Class
subclass of: lymphedema AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a hymphedema AE that has marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13804

Grade 1 superior vena cava syndrome AE
type: Class
subclass of: Superior vena cava syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a superior vena cava syndrome AE that has asymptomatic; incidental finding of SVC thrombosis
definition editor: YH, MW
see also: CTCAE: E13820

Grade 2 superior vena cava syndrome AE
type: Class
subclass of: Superior vena cava syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a superior vena cava syndrome AEthat has symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy)
definition editor: YH, MW
see also: CTCAE: E13821

Grade 3 superior vena cava syndrome AE
type: Class
subclass of: Superior vena cava syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a superior vena cava syndrome AE that has severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting)
definition editor: YH, MW
see also: CTCAE: E13822

Grade 4 superior vena cava syndrome AE
type: Class
subclass of: Superior vena cava syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a superior vena cava syndrome AE that has life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery)
definition editor: YH, MW
see also: CTCAE: E13823

Grade 1 thromboembolic event AE
type: Class
subclass of: thromboembolism AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a thromboembolic event AE that has venous thrombosis (e.g., superficial thrombosis)
definition editor: YH, MW
see also: CTCAE: E13826

Grade 2 thromboembolic event AE
type: Class
subclass of: thromboembolism AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a thromboembolic event AE that has venous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated
definition editor: YH, MW
see also: CTCAE: E13827

Grade 3 thromboembolic event AE
type: Class
subclass of: thromboembolism AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a thromboembolic event AE that has thrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus), medical intervention indicated
definition editor: YH, MW
see also: CTCAE: E13828

Grade 4 thromboembolic event AE
type: Class
subclass of: thromboembolism AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a thromboembolic event AE that has life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated
definition editor: YH, MW
see also: CTCAE: E13829

Grade 2 visceral arterial ischemia AE
type: Class
subclass of: visceral arterial ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a visceral arterial ischemia AE that has brief (<24 hrs) episode of ischemia managed medically and without permanent deficit
definition editor: YH, MW
see also: CTCAE: E13844

Grade 3 visceral arterial ischemia AE
type: Class
subclass of: visceral arterial ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a visceral arterial ischemia AE that has prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated
definition editor: YH, MW
see also: CTCAE: E13845

Grade 1 menopause AE
type: Class
subclass of: menopause AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a menopause AE that the menopause occurres at age 46 - 53 years of age
definition editor: YH, MW
see also: CTCAE: E13751

Grade 2 menopause AE
type: Class
subclass of: menopause AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a menopause AE that the menopause occurres at age 40 - 45 years of age
definition editor: YH, MW
see also: CTCAE: E13752

Grade 3 menopause AE
type: Class
subclass of: menopause AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a menopause AE that the menopause occurres before age 40 years of age
definition editor: YH, MW
see also: CTCAE: E13753

Grade 1 body odor AE
type: Class
subclass of: body odor AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a body odor AE that has mild odor; physician intervention not indicated; self care interventions
definition editor: YH, MW
see also: CTCAE: E13615

Grade 2 body odor AE
type: Class
subclass of: body odor AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a body odor AE that has pronounced odor; psychosocial impact; patient seeks medical intervention
definition editor: YH, MW
see also: CTCAE: E13616

Grade 1 bullous dermatitis AE
type: Class
subclass of: bullous dermatitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a bullous AE that has asymptomatic; blisters covering <10% BSA
definition editor: YH, MW
see also: CTCAE: E13618

Grade 2 bullous dermatitis AE
type: Class
subclass of: bullous dermatitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a bullous AE that has blisters covering 10 - 30% BSA; painful blisters; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13619

Grade 3 bullous dermatitis AE
type: Class
subclass of: bullous dermatitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a bullous AE that has blisters covering >30% BSA; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13620

Grade 4 bullous dermatitis AE
type: Class
subclass of: bullous dermatitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a bullous AE that has blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated
definition editor: YH, MW
see also: CTCAE: E13621

Grade 2 erythroderma AE
type: Class
subclass of: erythroderma AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an erythroderma AE that has erythema covering >90% BSA without associated symptoms; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13634

Grade 3 erythroderma AE
type: Class
subclass of: erythroderma AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an erythroderma AE that has erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13635

Grade 4 erythroderma AE
type: Class
subclass of: erythroderma AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: an erythroderma AE that has erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated
definition editor: YH, MW
see also: CTCAE: E13636

Grade 1 fat atrophy AE
type: Class
subclass of: fat atrophy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a fat atrophy AE that is covering <10% BSA and asymptomatic
definition editor: YH, MW
see also: CTCAE: E13639

Grade 2 fat atrophy AE
type: Class
subclass of: fat atrophy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a fat atrophy AE that is covering 10 - 30% BSA and associated with erythema or tenderness; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13640

Grade 3 fat atrophy AE
type: Class
subclass of: fat atrophy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a fat atrophy AE that is covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL
definition editor: YH, MW
see also: CTCAE: E13641

Grade 1 hirsutism AE
type: Class
subclass of: hirsutism AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hirsutism AE that is In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair
definition editor: YH, MW
see also: CTCAE: E13643

Grade 2 hirsutism AE
type: Class
subclass of: hirsutism AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a hirsutism AE that In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact
definition editor: YH, MW
see also: CTCAE: E13644

Grade 1 hypertrichosis AE
type: Class
subclass of: hypertrichosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hypertrichosis AE that has increased in length, thickness or density of hair. The patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal
definition editor: YH, MW
see also: CTCAE: E13650

Grade 2 hypertrichosis AE
type: Class
subclass of: hypertrichosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a hypertrichosis AE that has increased in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact
definition editor: YH, MW
see also: CTCAE: E13651

Grade 3 hypohidrosis AE
type: Class
subclass of: hypohidrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a hypertrichosis AE that has increased in body temperature; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13654

Grade 4 hypohidrosis AE
type: Class
subclass of: hypohidrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a hypertrichosis AE that has heat stroke
definition editor: YH, MW
see also: CTCAE: E13655

Grade 1 lipohypertrophy AE
type: Class
subclass of: lipohypertrophy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a lipohypertrophy AE that has asymptomatic and covering <10% BSA
definition editor: YH, MW
see also: CTCAE: E13658

Grade 2 lipohypertrophy AE
type: Class
subclass of: lipohypertrophy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a lipohypertrophy AE that covers 10 - 30% BSA and associated tenderness; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13659

Grade 3 lipohypertrophy AE
type: Class
subclass of: lipohypertrophy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a lipohypertrophy AE that covers >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13660

Grade 1 nail loss AE
type: Class
subclass of: nail loss AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a nail loss AE that has asymptomatic separation of the nail bed from the nail plate or nail loss
definition editor: YH, MW
see also: CTCAE: E13664

Grade 2 nail loss AE
type: Class
subclass of: nail loss AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a nail loss AE that has symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13665

Grade 1 rash acneiform AE
type: Class
subclass of: acneiform rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a rash acneiform AE that has papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness
definition editor: YH, MW
see also: CTCAE: E13695

Grade 2 rash acneiform AE
type: Class
subclass of: acneiform rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a rash acneiform AE that has papules and/or pustules covering 10 - 30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13696

Grade 3 rash acneiform AE
type: Class
subclass of: acneiform rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a rash acneiform AE that has papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self care ADL; associated with local superinfection with oral antibiotics indicated
definition editor: YH, MW
see also: CTCAE: E13697

Grade 4 rash acneiform AE
type: Class
subclass of: acneiform rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a rash acneiform AE that has papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences
definition editor: YH, MW
see also: CTCAE: E13698

Grade 1 rash maculo-papular AE
type: Class
subclass of: maculo-papular rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a rash maculopapular AE that has macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness)
definition editor: YH, MW
see also: CTCAE: E13701

Grade 2 rash maculo-papular AE
type: Class
subclass of: maculo-papular rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a rash maculopapular AE that has macules/papules covering 10 - 30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13702

Grade 3 rash maculo-papular AE
type: Class
subclass of: maculo-papular rash AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a rash maculopapular AE that has macules/papules covering >30% BSA with or without associated symptoms; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13703

Grade 1 skin induration AE
type: Class
subclass of: skin induration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a skin induration AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
definition editor: YH, MW
see also: CTCAE: E13725

Grade 2 skin induration AE
type: Class
subclass of: skin induration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a skin induration AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13726

Grade 3 skin induration AE
type: Class
subclass of: skin induration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a skin induration AE that has severe induration, unable to slide or pinch skin; limiting joint movement or orifice (e.g., mouth, anus); limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13727

Grade 4 skin induration AE
type: Class
subclass of: skin induration AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a skin induration AE that has generalized; associated with signs or symptoms of impaired breathing or feeding
definition editor: YH, MW
see also: CTCAE: E13728

Grade 2 bronchial fistula AE
type: Class
subclass of: bronchial fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a bronchial fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13324

Grade 3 bronchial fistula AE
type: Class
subclass of: bronchial fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a bronchial fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
definition editor: YH, MW
see also: CTCAE: E13325

Grade 4 bronchial fistula AE
type: Class
subclass of: bronchial fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a bronchial fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated
definition editor: YH, MW
see also: CTCAE: E13326

Grade 2 bronchial obstruction AE
type: Class
subclass of: bronchial obstruction AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a bronchial obstruction AE that has symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators)
definition editor: YH, MW
see also: CTCAE: E13330

Grade 3 bronchial obstruction AE
type: Class
subclass of: bronchial obstruction AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a bronchial obstruction AE that has shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)
definition editor: YH, MW
see also: CTCAE: E13331

Grade 2 bronchial stricture AE
type: Class
subclass of: bronchial stricture AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a bronchial stricture AE that AE symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators)
definition editor: YH, MW
see also: CTCAE: E13336

Grade 3 bronchial stricture AE
type: Class
subclass of: bronchial stricture AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a bronchial stricture AE that AE shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)
definition editor: YH, MW
see also: CTCAE: E13337

Grade 3 bronchopleural fistula AE
type: Class
subclass of: bronchopleural fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a bronchopleural fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
definition editor: YH, MW
see also: CTCAE: E13343

Grade 4 bronchopleural fistula AE
type: Class
subclass of: bronchopleural fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a bronchopleural fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated
definition editor: YH, MW
see also: CTCAE: E13344

Grade 2 laryngeal fistula AE
type: Class
subclass of: laryngeal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a laryngeal fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13401

Grade 3 laryngeal fistula AE
type: Class
subclass of: laryngeal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a laryngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
definition editor: YH, MW
see also: CTCAE: E13402

Grade 4 laryngeal fistula AE
type: Class
subclass of: laryngeal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a laryngeal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies)
definition editor: YH, MW
see also: CTCAE: E13403

Grade 1 laryngeal hemorrhage AE
type: Class
subclass of: laryngeal hemorrhage AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a laryngeal hemorrhage AE that has mild cough or trace hemoptysis; laryngoscopic findings
definition editor: YH, MW
see also: CTCAE: E13406

Grade 1 laryngeal inflammation AE
type: Class
subclass of: laryngeal inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a laryngeal inflammation AE that has mild sore throat; raspy voice
definition editor: YH, MW
see also: CTCAE: E13412

Grade 2 laryngeal inflammation AE
type: Class
subclass of: laryngeal inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a laryngeal inflammation AE that has moderate sore throat; analgesics indicated
definition editor: YH, MW
see also: CTCAE: E13413

Grade 3 laryngeal inflammation AE
type: Class
subclass of: laryngeal inflammation AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a laryngeal inflammation AE that has severe throat pain; endoscopic intervention indicated
definition editor: YH, MW
see also: CTCAE: E13414

Grade 1 laryngeal mucositis AE
type: Class
subclass of: laryngeal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a laryngeal mucositis AE that has endoscopic findings only; mild discomfort with normal intake
definition editor: YH, MW
see also: CTCAE: E13416

Grade 2 laryngeal mucositis AE
type: Class
subclass of: laryngeal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a laryngeal mucositis AE that has moderate discomfort; altered oral intake
definition editor: YH, MW
see also: CTCAE: E13417

Grade 3 laryngeal mucositis AE
type: Class
subclass of: laryngeal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a laryngeal mucositis AE that has severe pain; severely altered eating/swallowing; medical intervention indicated
definition editor: YH, MW
see also: CTCAE: E13418

Grade 4 laryngeal mucositis AE
type: Class
subclass of: laryngeal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a laryngeal mucositis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
definition editor: YH, MW
see also: CTCAE: E13419

Grade 2 laryngeal obstruction AE
type: Class
subclass of: laryngeal obstruction AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a laryngeal obstruction AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13423

Grade 3 laryngeal obstruction AE
type: Class
subclass of: laryngeal obstruction AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a laryngeal obstruction AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)
definition editor: YH, MW
see also: CTCAE: E13424

Grade 2 laryngeal stenosis AE
type: Class
subclass of: laryngeal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a laryngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids)
definition editor: YH, MW
see also: CTCAE: E13429

Grade 3 laryngeal stenosis AE
type: Class
subclass of: laryngeal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a laryngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)
definition editor: YH, MW
see also: CTCAE: E13430

Grade 2 laryngopharyngeal dysesthesia AE
type: Class
subclass of: Laryngopharyngeal dysesthesia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a laryngopharyngeal dysesthesia AE that has moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and or anxiolytic indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13435

Grade 3 laryngopharyngeal dysesthesia AE
type: Class
subclass of: Laryngopharyngeal dysesthesia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a laryngopharyngeal dysesthesia AE that has severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13436

Grade 2 laryngospasm AE
type: Class
subclass of: laryngospasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a laryngospasm AE that has transient episode; intervention not indicated
definition editor: YH, MW
see also: CTCAE: E13440

Grade 3 laryngospasm AE
type: Class
subclass of: laryngospasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a laryngospasm AE that has recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage)
definition editor: YH, MW
see also: CTCAE: E13441

Grade 4 laryngospasm AE
type: Class
subclass of: laryngospasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a laryngospasm AE that has persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection)
definition editor: YH, MW
see also: CTCAE: E13442

Grade 2 pharyngeal fistula AE
type: Class
subclass of: pharyngeal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a pharyngeal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13456

Grade 3 pharyngeal fistula AE
type: Class
subclass of: pharyngeal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a pharyngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
definition editor: YH, MW
see also: CTCAE: E13457

Grade 1 pharyngeal mucositis AE
type: Class
subclass of: pharyngeal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a pharyngeal mucositis AE that has endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated
definition editor: YH, MW
see also: CTCAE: E13467

Grade 2 pharyngeal mucositis AE
type: Class
subclass of: pharyngeal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a pharyngeal mucositis AE that has moderate pain and analgesics indicated; altered oral intake; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13468

Grade 3 pharyngeal mucositis AE
type: Class
subclass of: pharyngeal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a pharyngeal mucositis AE that has severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13469

Grade 3 pharyngeal necrosis AE
type: Class
subclass of: pharyngeal necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a pharyngeal necrosis AE that has inability to aliment adequately by GI tract; tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated
definition editor: YH, MW
see also: CTCAE: E13473

Grade 2 pharyngeal stenosis AE
type: Class
subclass of: pharyngeal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a pharyngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13478

Grade 3 pharyngeal stenosis AE
type: Class
subclass of: pharyngeal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a pharyngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)
definition editor: YH, MW
see also: CTCAE: E13479

Grade 4 pharyngeal stenosis AE
type: Class
subclass of: pharyngeal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a pharyngeal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
definition editor: YH, MW
see also: CTCAE: E13480

Grade 2 pulmonary fistula AE
type: Class
subclass of: pulmonary fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a pulmonary fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13535

Grade 3 pulmonary fistula AE
type: Class
subclass of: pulmonary fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a pulmonary fistula AE that has limiting self care ADL; endoscopic stenting or operative intervention indicated
definition editor: YH, MW
see also: CTCAE: E13536

Grade 1 retinoic acid syndrome AE
type: Class
subclass of: retinoic acid syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a retinoic acid syndrome AE that has fluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated
definition editor: YH, MW
see also: CTCAE: E13555

Grade 1 sleep apnea AE
type: Class
subclass of: sleep apnea AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a sleep apnea AE that has snoring and nocturnal sleep arousal without apneic periods
definition editor: YH, MW
see also: CTCAE: E13567

Grade 2 sleep apnea AE
type: Class
subclass of: sleep apnea AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a sleep apnea AE that has moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13568

Grade 3 sleep apnea AE
type: Class
subclass of: sleep apnea AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a sleep apnea AE that has oxygen desaturation; associated with hypertension; medical intervention indicated; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13569

Grade 4 sleep apnea AE
type: Class
subclass of: sleep apnea AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a sleep apnea AE that has cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated
definition editor: YH, MW
see also: CTCAE: E13570

Grade 2 tracheal fistula AE
type: Class
subclass of: tracheal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a tracheal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13585

Grade 3 tracheal fistula AE
type: Class
subclass of: tracheal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a tracheal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
definition editor: YH, MW
see also: CTCAE: E13586

Grade 4 tracheal fistula AE
type: Class
subclass of: tracheal fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a tracheal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies)
definition editor: YH, MW
see also: CTCAE: E13587

Grade 1 tracheal mucositis AE
type: Class
subclass of: tracheal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a tracheal mucositis AE that has endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms
definition editor: YH, MW
see also: CTCAE: E13590

Grade 3 tracheal mucositis AE
type: Class
subclass of: tracheal mucositis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a tracheal mucositis AE that has severe pain; hemorrhage or respiratory symptoms; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13592

Grade 2 tracheal stenosis AE
type: Class
subclass of: tracheal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a tracheal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids)
definition editor: YH, MW
see also: CTCAE: E13597

Grade 3 tracheal stenosis AE
type: Class
subclass of: tracheal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a tracheal stenosis AE that has stridor or respiratory distress limiting self care ADL; endoscopic intervention indicated (e.g., stent, laser)
definition editor: YH, MW
see also: CTCAE: E13598

Grade 4 tracheal stenosis AE
type: Class
subclass of: tracheal stenosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a tracheal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
definition editor: YH, MW
see also: CTCAE: E13599

Grade 3 azoospermia AE
type: Class
subclass of: azoospermia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an azoospermia AE that has absence of sperm in ejaculate
definition editor: YH, MW
see also: CTCAE: E13068

Grade 3 breast atrophy AE
type: Class
subclass of: breast atrophy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: A breast atrophy AE that has asymmetry >1/3 of breast volume; severe atrophy
definition editor: YH, MW
see also: CTCAE: E13072

Grade 1 ejaculation disorder AE
type: Class
subclass of: ejaculation disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: an ejaculation disorder AE that has diminished ejaculation
definition editor: YH, MW
see also: CTCAE: E13086

Grade 2 ejaculation disorder AE
type: Class
subclass of: ejaculation disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an ejaculation disorder AE that has anejaculation or retrograde ejaculation
definition editor: YH, MW
see also: CTCAE: E13087

Grade 1 genital edema AE
type: Class
subclass of: genital edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a genital edema AE that has mild swelling or obscuration of anatomic architecture on close inspection
definition editor: YH, MW
see also: CTCAE: E13112

Grade 2 genital edema AE
type: Class
subclass of: genital edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a genital edema AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour
definition editor: YH, MW
see also: CTCAE: E13113

Grade 3 genital edema AE
type: Class
subclass of: genital edema AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a genital edema AE that has lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13114

Grade 1 gynecomastia AE
type: Class
subclass of: gynecomastia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a gynecomastia AE that has asymptomatic breast enlargement
definition editor: YH, MW
see also: CTCAE: E13116

Grade 2 gynecomastia AE
type: Class
subclass of: gynecomastia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a gynecomastia AE that has symptomatic (e.g., pain or psychosocial impact)
definition editor: YH, MW
see also: CTCAE: E13117

Grade 1 hematosalpinx AE
type: Class
subclass of: hematosalpinx AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hematosalpinx AE that has minimal bleeding identified on imaging study or laparoscopy; intervention not indicated
definition editor: YH, MW
see also: CTCAE: E13120

Grade 1 irregular menstruation AE
type: Class
subclass of: menstruation irregular AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: an irregular menstruation AE that has intermittent menses with skipped menses for no more than 1 to 3 months
definition editor: YH, MW
see also: CTCAE: E13126

Grade 2 irregular menstruation AE
type: Class
subclass of: menstruation irregular AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an irregular menstruation AE that has intermittent menses with skipped menses for more than 4 to 6 months
definition editor: YH, MW
see also: CTCAE: E13127

Grade 3 irregular menstruation AE
type: Class
subclass of: menstruation irregular AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an irregular menstruation AE that has persistent amenorrhea for more than 6 months
definition editor: YH, MW
see also: CTCAE: E13128

Grade 1 lactation disorder AE
type: Class
subclass of: lactation disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a lactation disorder AE that has mild changes in lactation, not significantly affecting production or expression of breast milk
definition editor: YH, MW
see also: CTCAE: E13130

Grade 2 lactation disorder AE
type: Class
subclass of: lactation disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a lactation disorder AE that has changes in lactation, significantly affecting breast production or expression of breast milk
definition editor: YH, MW
see also: CTCAE: E13131

Grade 1 nipple deformity AE
type: Class
subclass of: nipple deformity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a nipple deformity AE that has asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex
definition editor: YH, MW
see also: CTCAE: E13139

Grade 2 nipple deformity AE
type: Class
subclass of: nipple deformity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a nipple deformity AE that has symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex
definition editor: YH, MW
see also: CTCAE: E13140

Grade 1 oligospermia AE
type: Class
subclass of: oligospermia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: an oligospermia AE requires sperm concentration >48 million/mL or motility >68%
definition editor: YH, MW
see also: CTCAE: E13142

Grade 2 oligospermia AE
type: Class
subclass of: oligospermia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an oligospermia AE requires sperm concentration 13 - 48 million/mL or motility 32 - 68%
definition editor: YH, MW
see also: CTCAE: E13143

Grade 3 oligospermia AE
type: Class
subclass of: oligospermia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an oligospermia AE requires sperm concentration <13 million/mL or motility <32%
definition editor: YH, MW
see also: CTCAE: E13144

Grade 2 testicular disorder AE
type: Class
subclass of: testicular disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a testicular disorder AE that has symptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13217

Grade 3 testicular disorder AE
type: Class
subclass of: testicular disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a testicular disorder AE that has severe symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated
definition editor: YH, MW
see also: CTCAE: E13218

Grade 1 vaginal discharge AE
type: Class
subclass of: vaginal discharge AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a vaginal discharge AE that has mild vaginal discharge (greater than baseline for patient)
definition editor: YH, MW
see also: CTCAE: E13252

Grade 2 vaginal discharge AE
type: Class
subclass of: vaginal discharge AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a vaginal discharge AE that has moderate to heavy vaginal discharge; use of perineal pad or tampon indicated
definition editor: YH, MW
see also: CTCAE: E13253

Grade 2 bladder spasm AE
type: Class
subclass of: bladder spasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a bladder spasm AE that has antispasmodics indicated
definition editor: YH, MW
see also: CTCAE: E12986

Grade 3 bladder spasm AE
type: Class
subclass of: bladder spasm AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a bladder spasm AE that has hospitalization indicated
definition editor: YH, MW
see also: CTCAE: E12987

Grade 1 chronic kidney disease AE
type: Class
subclass of: chronic kidney disease AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a chronic kidney disease AE that requires eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN - 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5
definition editor: YH, MW
see also: CTCAE: E12989

Grade 2 chronic kidney disease AE
type: Class
subclass of: chronic kidney disease AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a chronic kidney disease AE that requires eGFR or CrCl 59 - 30 ml/min/1.73 m2
definition editor: YH, MW
see also: CTCAE: E12990

Grade 3 chronic kidney disease AE
type: Class
subclass of: chronic kidney disease AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a chronic kidney disease AE that requires eGFR or CrCl 29 - 15 ml/min/1.73 m2
definition editor: YH, MW
see also: CTCAE: E12991

Grade 4 chronic kidney disease AE
type: Class
subclass of: chronic kidney disease AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a chronic kidney disease AE that requires eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated
definition editor: YH, MW
see also: CTCAE: E12992

Grade 1 cystitis noninfective AE
type: Class
subclass of: cystitis noninfective AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a cystitis noninfective AE that has microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence
definition editor: YH, MW
see also: CTCAE: E12995

Grade 2 cystitis noninfective AE
type: Class
subclass of: cystitis noninfective AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a cystitis noninfective AE that has moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E12996

Grade 3 cystitis noninfective AE
type: Class
subclass of: cystitis noninfective AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a cystitis noninfective AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated
definition editor: YH, MW
see also: CTCAE: E12997

Grade 1 proteinuria AE
type: Class
subclass of: proteinuria AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a proteinuria AE that requires 1+ proteinuria; urinary protein <1.0 g/24 hrs
definition editor: YH, MW
see also: CTCAE: E13009

Grade 2 proteinuria AE
type: Class
subclass of: proteinuria AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a proteinuria AE that requires
definition editor: YH, MW
see also: CTCAE: E13010

Grade 3 proteinuria AE
type: Class
subclass of: proteinuria AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a proteinuria AE that requires
definition editor: YH, MW
see also: CTCAE: E13011

Grade 1 renal calculi AE
type: Class
subclass of: renal calculus AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a renal calculi AE that has asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated
definition editor: YH, MW
see also: CTCAE: E13019

Grade 2 renal calculi AE
type: Class
subclass of: renal calculus AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a renal calculi AE that has symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated
definition editor: YH, MW
see also: CTCAE: E13020

Grade 3 renal calculi AE
type: Class
subclass of: renal calculus AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a renal calculi AE that has hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated
definition editor: YH, MW
see also: CTCAE: E13021

Grade 2 urinary fistula AE
type: Class
subclass of: urinary fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an urinary fistula AE that has noninvasive intervention indicated; urinary or suprapubic catheter placement indicated
definition editor: YH, MW
see also: CTCAE: E13035

Grade 3 urinary fistula AE
type: Class
subclass of: urinary fistula AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an urinary fistula AE that has limiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated
definition editor: YH, MW
see also: CTCAE: E13036

Grade 2 urinary tract obstruction AE
type: Class
subclass of: urinary tract obstruction AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an urinary tract obstruction AE that has symptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated
definition editor: YH, MW
see also: CTCAE: E13054

Grade 3 urinary tract obstruction AE
type: Class
subclass of: urinary tract obstruction AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an urinary tract obstruction AE that has symptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic or operative intervention indicated
definition editor: YH, MW
see also: CTCAE: E13055

Grade 1 mania AE
type: Class
subclass of: mania AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a mania AE that has mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep)
definition editor: YH, MW
see also: CTCAE: E12937

Grade 2 mania AE
type: Class
subclass of: mania AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a mania AE that has moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene)
definition editor: YH, MW
see also: CTCAE: E12938

Grade 3 mania AE
type: Class
subclass of: mania AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a mania AE that has severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated
definition editor: YH, MW
see also: CTCAE: E12939

Grade 2 fetal growth retardation AE
type: Class
subclass of: fetal growth retardation AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a fetal growth retardation AE that has <10% percentile of weight for gestational age
definition editor: YH, MW
see also: CTCAE: E12858

Grade 3 fetal growth retardation AE
type: Class
subclass of: fetal growth retardation AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a fetal growth retardation AE that has <5% percentile of weight for gestational age
definition editor: YH, MW
see also: CTCAE: E12859

Grade 4 fetal growth retardation AE
type: Class
subclass of: fetal growth retardation AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a fetal growth retardation AE that has <1% percentile of weight for gestational age
definition editor: YH, MW
see also: CTCAE: E12860

Grade 1 premature delivery AE
type: Class
subclass of: premature delivery AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a premature delivery AE that has delivery of a liveborn infant at >34 to 37 weeks gestation
definition editor: YH, MW
see also: CTCAE: E12868

Grade 2 premature delivery AE
type: Class
subclass of: premature delivery AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a premature delivery AE that has delivery of a liveborn infant at >28 to 34 weeks gestation
definition editor: YH, MW
see also: CTCAE: E12869

Grade 3 premature delivery AE
type: Class
subclass of: premature delivery AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a premature delivery AE that has delivery of a liveborn infant at 24 to 28 weeks gestation
definition editor: YH, MW
see also: CTCAE: E12870

Grade 4 premature delivery AE
type: Class
subclass of: premature delivery AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a premature delivery AE that has delivery of a liveborn infant at 24 weeks of gestation or less
definition editor: YH, MW
see also: CTCAE: E12871

Grade 1 spasticity AE
type: Class
subclass of: muscle spasticity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a spasticity AE that has mild or slight increase in muscle tone
definition editor: YH, MW
see also: CTCAE: E12821

Grade 2 spasticity AE
type: Class
subclass of: muscle spasticity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a spasticity AE that has moderate increase in muscle tone and increase in resistance through range of motion
definition editor: YH, MW
see also: CTCAE: E12822

Grade 3 spasticity AE
type: Class
subclass of: muscle spasticity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a spasticity AE that has severe increase in muscle tone and increase in resistance through range of motion
definition editor: YH, MW
see also: CTCAE: E12823

Grade 4 spasticity AE
type: Class
subclass of: muscle spasticity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a spasticity AE that has life-threatening; unable to move active or passive range of motion
definition editor: YH, MW
see also: CTCAE: E12824

Grade 3 treatment related secondary malignancy AE
type: Class
subclass of: treatment related secondary malignancy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a treatment related secondary malignancy AE that has non life-threatening secondary malignancy
definition editor: YH, MW
see also: CTCAE: E12562

Grade 4 treatment related secondary malignancy AE
type: Class
subclass of: treatment related secondary malignancy AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a treatment related secondary malignancy AE that has acute life-threatening secondary malignancy; blast crisis in leukemia
definition editor: YH, MW
see also: CTCAE: E12563

Grade 2 abdominal soft tissue necrosis AE
type: Class
subclass of: abdominal soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an abdominal soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
definition editor: YH, MW
see also: CTCAE: E12370

Grade 3 abdominal soft tissue necrosis AE
type: Class
subclass of: abdominal soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an abdominal soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g. tissue reconstruction, flap or grafting)
definition editor: YH, MW
see also: CTCAE: E12371

Grade 1 fibrosis deep connective tissue AE
type: Class
subclass of: fibrosis deep connective tissue AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a fibrosis deep connective tissue AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
definition editor: YH, MW
see also: CTCAE: E12409

Grade 2 fibrosis deep connective tissue AE
type: Class
subclass of: fibrosis deep connective tissue AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a fibrosis deep connective tissue AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E12410

Grade 3 fibrosis deep connective tissue AE
type: Class
subclass of: fibrosis deep connective tissue AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a fibrosis deep connective tissue AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g. mouth, anus); limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E12411

Grade 4 fibrosis deep connective tissue AE
type: Class
subclass of: fibrosis deep connective tissue AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a fibrosis deep connective tissue AE that has generalized; associated with signs or symptoms of impaired breathing or feeding
definition editor: YH, MW
see also: CTCAE: E12412

Grade 1 growth suppression AE
type: Class
subclass of: growth suppression AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a growth suppression AE that has reduction in growth velocity by 10 - 29% ideally measured over the period of a year
definition editor: YH, MW
see also: CTCAE: E12423

Grade 2 growth suppression AE
type: Class
subclass of: growth suppression AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a growth suppression AE that has reduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve
definition editor: YH, MW
see also: CTCAE: E12424

Grade 3 growth suppression AE
type: Class
subclass of: growth suppression AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a growth suppression AE that has reduction in growth velocity of >=50% ideally measured over the period of a year
definition editor: YH, MW
see also: CTCAE: E12425

Grade 2 head soft tissue necrosis AE
type: Class
subclass of: head soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a head soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
definition editor: YH, MW
see also: CTCAE: E12427

Grade 3 head soft tissue necrosis AE
type: Class
subclass of: head soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a head soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
definition editor: YH, MW
see also: CTCAE: E12428

Grade 1 joint range of motion decreased cervical spine AE
type: Class
subclass of: joint range of motion decreased cervical spine AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a joint range of motion decreased cervical spine AE that has mild restriction of rotation or flexion between 60 - 70 degrees
definition editor: YH, MW
see also: CTCAE: E12440

Grade 2 joint range of motion decreased cervical spine AE
type: Class
subclass of: joint range of motion decreased cervical spine AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a joint range of motion decreased cervical spine AE that has rotation <60 degrees to right or left; <60 degrees of flexion
definition editor: YH, MW
see also: CTCAE: E12441

Grade 3 joint range of motion decreased cervical spine AE
type: Class
subclass of: joint range of motion decreased cervical spine AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a joint range of motion decreased cervical spine AE that has ankylosed/fused over multiple segments with no C-spine rotation
definition editor: YH, MW
see also: CTCAE: E12442

Grade 1 joint range of motion decreased lumbar spine AE
type: Class
subclass of: joint range of motion decreased lumbar spine AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a joint range of motion decreased lumbar spine AE that has stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity
definition editor: YH, MW
see also: CTCAE: E12444

Grade 2 joint range of motion decreased lumbar spine AE
type: Class
subclass of: joint range of motion decreased lumbar spine AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a joint range of motion decreased lumbar spine AE that has pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor
definition editor: YH, MW
see also: CTCAE: E12445

Grade 3 joint range of motion decreased lumbar spine AE
type: Class
subclass of: joint range of motion decreased lumbar spine AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a joint range of motion decreased lumbar spine AE that requires <50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object)
definition editor: YH, MW
see also: CTCAE: E12446

Grade 2 neck soft tissue necrosis AE
type: Class
subclass of: neck soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a neck soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
definition editor: YH, MW
see also: CTCAE: E12498

Grade 3 neck soft tissue necrosis AE
type: Class
subclass of: neck soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a neck soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
definition editor: YH, MW
see also: CTCAE: E12499

Grade 2 pelvic soft tissue necrosis AE
type: Class
subclass of: pelvic soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a pelvic soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
definition editor: YH, MW
see also: CTCAE: E12517

Grade 3 pelvic soft tissue necrosis AE
type: Class
subclass of: pelvic soft tissue necrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a pelvic soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
definition editor: YH, MW
see also: CTCAE: E12518

Grade 1 scoliosis AE
type: Class
subclass of: scoliosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a scoliosis AE that requires <20 degrees; clinically undetectable
definition editor: YH, MW
see also: CTCAE: E12522

Grade 2 scoliosis AE
type: Class
subclass of: scoliosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a scoliosis AE that requires >20 - 45 degrees; visible by forward flexion; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E12523

Grade 3 scoliosis AE
type: Class
subclass of: scoliosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a scoliosis AE that requires >45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL; disabling
definition editor: YH, MW
see also: CTCAE: E12524

Grade 2 soft tissue necrosis lower limb AE
type: Class
subclass of: soft tissue necrosis lower limb AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a soft tissue necrosis lower limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
definition editor: YH, MW
see also: CTCAE: E12526

Grade 3 soft tissue necrosis lower limb AE
type: Class
subclass of: soft tissue necrosis lower limb AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a soft tissue necrosis lower limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
definition editor: YH, MW
see also: CTCAE: E12527

Grade 2 soft tissue necrosis upper limb AE
type: Class
subclass of: soft tissue necrosis upper limb AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a soft tissue necrosis upper limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
definition editor: YH, MW
see also: CTCAE: E12531

Grade 3 soft tissue necrosis upper limb AE
type: Class
subclass of: soft tissue necrosis upper limb AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a soft tissue necrosis upper limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
definition editor: YH, MW
see also: CTCAE: E12532

Grade 1 superficial soft tissue fibrosis AE
type: Class
subclass of: superficial soft tissue fibrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a Superficial soft tissue fibrosis AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
definition editor: YH, MW
see also: CTCAE: E12536

Grade 2 superficial soft tissue fibrosis AE
type: Class
subclass of: superficial soft tissue fibrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a Superficial soft tissue fibrosis AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E12537

Grade 3 superficial soft tissue fibrosis AE
type: Class
subclass of: superficial soft tissue fibrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a Superficial soft tissue fibrosis AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E12538

Grade 4 superficial soft tissue fibrosis AE
type: Class
subclass of: superficial soft tissue fibrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a superficial soft tissue fibrosis AE that has generalized; associated with signs or symptoms of impaired breathing or feeding
definition editor: YH, MW
see also: CTCAE: E12539

Grade 1 trismus AE
type: Class
subclass of: trismus AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a trismus AE that has decreased ROM (range of motion) without impaired eating
definition editor: YH, MW
see also: CTCAE: E12542

Grade 2 trismus AE
type: Class
subclass of: trismus AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a trismus AE that has decreased ROM requiring small bites, soft foods or purees
definition editor: YH, MW
see also: CTCAE: E12543

Grade 3 trismus AE
type: Class
subclass of: trismus AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a trismus AE that has decreased ROM with inability to adequately aliment or hydrate orally
definition editor: YH, MW
see also: CTCAE: E12544

Grade 1 unequal limb length AE
type: Class
subclass of: unequal limb length AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: An unequal limb length AE that has mild length discrepancy <2 cm
definition editor: YH, MW
see also: CTCAE: E12546

Grade 2 unequal limb length AE
type: Class
subclass of: unequal limb length AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: An unequal limb length AE that has moderate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E12547

Grade 3 unequal limb length AE
type: Class
subclass of: unequal limb length AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: An unequal limb length AE that has severe length discrepancy >5 cm; limiting self care ADL; disabling; operative intervention indicated
definition editor: YH, MW
see also: CTCAE: E12548

Grade 1 alkalosis AE
type: Class
subclass of: alkalosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a alkalosis AE that requires pH >normal, but <=7.5
definition editor: YH, MW
see also: CTCAE: E12248

Grade 3 alkalosis AE
type: Class
subclass of: alkalosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a alkalosis AE that requires pH >7.5
definition editor: YH, MW
see also: CTCAE: E12249

Grade 2 glucose intolerance AE
type: Class
subclass of: glucose intolerance AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a glucose intolerance AE that has symptomatic; dietary modification or oral agent indicated
definition editor: YH, MW
see also: CTCAE: E12266

Grade 3 glucose intolerance AE
type: Class
subclass of: glucose intolerance AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a glucose intolerance AE that has severe symptoms; insulin indicated
definition editor: YH, MW
see also: CTCAE: E12267

Grade 1 hypermagnesemia AE
type: Class
subclass of: hypermagnesemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hypermagnesemia AE that requires >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L
definition editor: YH, MW
see also: CTCAE: E12289

Grade 3 hypermagnesemia AE
type: Class
subclass of: hypermagnesemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a hypermagnesemia AE that requires >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L
definition editor: YH, MW
see also: CTCAE: E12290

Grade 4 hypermagnesemia AE
type: Class
subclass of: hypermagnesemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a hypermagnesemia AE that requires >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences
definition editor: YH, MW
see also: CTCAE: E12291

Grade 1 hypernatremia AE
type: Class
subclass of: hypernatremia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hypernatremia AE that requires >ULN - 150 mmol/L
definition editor: YH, MW
see also: CTCAE: E12294

Grade 2 hypernatremia AE
type: Class
subclass of: hypernatremia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a hypernatremia AE that requires >150 - 155 mmol/L
definition editor: YH, MW
see also: CTCAE: E12295

Grade 3 hypernatremia AE
type: Class
subclass of: hypernatremia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a hypernatremia AE that requires >155 - 160 mmol/L; hospitalization indicated
definition editor: YH, MW
see also: CTCAE: E12296

Grade 4 hypernatremia AE
type: Class
subclass of: hypernatremia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a hypernatremia AE that requires >160 mmol/L; life-threatening consequences
definition editor: YH, MW
see also: CTCAE: E12297

Grade 1 hypokalemia AE
type: Class
subclass of: hypokalaemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hypokalemia AE that requires <LLN - 3.0 mmol/L
definition editor: YH, MW
see also: CTCAE: E12328

Grade 2 hypokalemia AE
type: Class
subclass of: hypokalaemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a hypokalemia AE that requires <LLN - 3.0 mmol/L; symptomatic; intervention indicated
definition editor: YH, MW
see also: CTCAE: E12329

Grade 3 hypokalemia AE
type: Class
subclass of: hypokalaemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a hypokalemia AE that requires <3.0 - 2.5 mmol/L; hospitalization indicated
definition editor: YH, MW
see also: CTCAE: E12330

Grade 4 hypokalemia AE
type: Class
subclass of: hypokalaemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a hypokalemia AE that requires <2.5 mmol/L; life-threatening consequences
definition editor: YH, MW
see also: CTCAE: E12331

Grade 1 hyponatremia AE
type: Class
subclass of: hyponatremia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hyponatremia AE that requires <LLN - 130 mmol/L
definition editor: YH, MW
see also: CTCAE: E12340

Grade 3 hyponatremia AE
type: Class
subclass of: hyponatremia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a hyponatremia AE that requires <130 - 120 mmol/L
definition editor: YH, MW
see also: CTCAE: E12341

Grade 4 hyponatremia AE
type: Class
subclass of: hyponatremia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a hyponatremia AE that requires <120 mmol/L; life-threatening consequences
definition editor: YH, MW
see also: CTCAE: E12342

Grade 2 obesity AE
type: Class
subclass of: obesity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an obesity AE that requires BMI 25 - 29.9 kg/m2
definition editor: YH, MW
see also: CTCAE: E12362

Grade 3 obesity AE
type: Class
subclass of: obesity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an obesity AE that requires BMI 30 - 39.9 kg/m2
definition editor: YH, MW
see also: CTCAE: E12363

Grade 4 obesity AE
type: Class
subclass of: obesity AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: an obesity AE that requires BMI >=40 kg/m2
definition editor: YH, MW
see also: CTCAE: E12364

Grade 3 flushing AE
type: Class
subclass of: flushing AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a flushing AE that has symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13774

Grade 2 hematoma AE
type: Class
subclass of: hematoma AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a hematoma AE that requires minimally invasive evacuation or aspiration
definition editor: YH, MW
see also: CTCAE: E13777

Grade 3 hematoma AE
type: Class
subclass of: hematoma AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a hematoma AE that requires transfusion, radiologic, endoscopic, or elective operative intervention
definition editor: YH, MW
see also: CTCAE: E13778

Grade 1 hypertension AE
type: Class
subclass of: hypertension AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: an hypertension AE that has prehypertension (systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg)
definition editor: YH, MW
see also: CTCAE: E13786

Grade 2 hypertension AE
type: Class
subclass of: hypertension AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an hypertension AE that for Adult: has stage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated; for Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated.
definition editor: YH, MW
see also: CTCAE: E13787

Grade 3 hypertension AE
type: Class
subclass of: hypertension AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an hypertension AE that for Adult has Stage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; for Pediatric: Same as adult.
definition editor: YH, MW
see also: CTCAE: E13788

Grade 4 hypertension AE
type: Class
subclass of: hypertension AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: an hypertension AE that for Adult has life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated; for Pediatric: Same as adult
definition editor: YH, MW
see also: CTCAE: E13789

Grade 2 peripheral ischemia AE
type: Class
subclass of: peripheral ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a peripheral ischaemia AE that has brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit
definition editor: YH, MW
see also: CTCAE: E13811

Grade 3 peripheral ischemia AE
type: Class
subclass of: peripheral ischemia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a peripheral ischaemia AE that has a recurring or prolonged (>=24 hrs) and/or invasive intervention indicated
definition editor: YH, MW
see also: CTCAE: E13812

Grade 3 vasculitis AE
type: Class
subclass of: vasculitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a vasculitis AE that shows severe symptoms, medical intervention indicated (e.g., steroids)
definition editor: YH, MW
see also: CTCAE: E13840

Grade 4 vasculitis AE
type: Class
subclass of: vasculitis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: a vasculitis AE that shows threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated
definition editor: YH, MW
see also: CTCAE: E13841

Grade 1 alopecia AE
type: Class
subclass of: alopecia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: an alopecia AE that has hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage
definition editor: YH, MW
see also: CTCAE: E13612

Grade 2 alopecia AE
type: Class
subclass of: alopecia AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an alopecia AE that has hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact
definition editor: YH, MW
see also: CTCAE: E13613

Grade 1 dry skin AE
type: Class
subclass of: dry skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a dry skin AE that is coverying <10% BSA and no associated erythema or pruritus
definition editor: YH, MW
see also: CTCAE: E13624

Grade 2 dry skin AE
type: Class
subclass of: dry skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a dry skin AE that is coverying 10 - 30% BSA and associated with erythema or pruritus; limiting instrumental ADL
definition editor: YH, MW
see also: CTCAE: E13625

Grade 3 dry skin AE
type: Class
subclass of: dry skin AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a dry skin AE that is coverying >30% BSA and associated with pruritus; limiting self care ADL
definition editor: YH, MW
see also: CTCAE: E13626

Grade 1 erythema multiforme AE
type: Class
subclass of: erythema multiforme AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: an erythema multiforme AE that has target lesions covering <10% BSA and not associated with skin tenderness
definition editor: YH, MW
see also: CTCAE: E13628

Grade 2 erythema multiforme AE
type: Class
subclass of: erythema multiforme AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: an erythema multiforme AE that has target lesions covering 10 - 30% BSA and associated with skin tenderness
definition editor: YH, MW
see also: CTCAE: E13629

Grade 3 erythema multiforme AE
type: Class
subclass of: erythema multiforme AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: an erythema multiforme AE that has target lesions covering >30% BSA and associated with oral or genital erosions
definition editor: YH, MW
see also: CTCAE: E13630

Grade 4 erythema multiforme AE
type: Class
subclass of: erythema multiforme AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G4
definition: an erythema multiforme AE that has target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated
definition editor: YH, MW
see also: CTCAE: E13631

Grade 1 hyperhidrosis AE
type: Class
subclass of: hyperhidrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a hyperhidros AE that shows limited to one site (palms, soles, or axillae); self care interventions
definition editor: YH, MW
see also: CTCAE: E13646

Grade 2 hyperhidrosis AE
type: Class
subclass of: hyperhidrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G2
definition: a hyperhidros AE that has Involving >1 site; patient seeks medical intervention; associated with psychosocial impact
definition editor: YH, MW
see also: CTCAE: E13647

Grade 3 hyperhidrosis AE
type: Class
subclass of: hyperhidrosis AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G3
definition: a hyperhidros AE that has Generalized involving sites other than palms, soles, or axillae; associated with electrolyte/hemodynamic imbalance
definition editor: YH, MW
see also: CTCAE: E13648

Grade 1 palmar-plantar erythrodysesthesia syndrome AE
type: Class
subclass of: palmar-plantar erythrodysesthesia syndrome AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G1
definition: a palmar-plantar erythrodysesthesia syndrome AE that has minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain
definition editor: YH, MW
see also: CTCAE: E13673

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