COB brings together key terms from a wide range of OBO projects to improve interoperability. Core Ontology for Biology and Biomedicine 2025-06-30 executed by intended to realize has plan intended plan process type has quantity Number of protons in an atomic nucleus has atomic number has number of atomic nuclei has inchi string obsolete elementary charge true A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it. This atom is closely related to ChEBI's atom, but not exactly equivalent to. atom A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom. This molecular entity is different than ChEBI's 'molecular entity'. We would like to have cardinality restrictions on the logic, but there are some technical limitations. molecule obsolete macromolecular entity true obsolete subcellular structure true A part of a multicellular organism that is a collection of cell components that are not all contained in one cell. gross anatomical part A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome 'Maximal functionally integrated unit' is intended to express unity, which Barry considers synonymous with BFO 'object'. Includes virus - we will later have a class for cellular organisms. organism A material entity processed by human activity with an intent to produce it. In the COB 2024 workshop there was much disagreement about this label. processed material entity obsolete geographical location true completely executed planned process A molecule that consists of nucleotides (unmodified nucleotide residues and/or modified nucleotide residues) linked by phosphodiester bonds or derivatives of such bonds. nucleic acid chain obsolete immaterial anatomical entity true obsolete gene product true obsolete action specification true A complex of two or more molecules that are not covalently bound. complex of molecules A process that is initiated by an agent who intends to carry out a plan to achieve an objective through one or more actions as described in a plan specification. planned process failed planned process A planned process that intends to output material entities from input material entities material processing obsolete cellular membrane true obsolete physical information carrier true characteristic A process during which an organism comes into contact with another entity. exposure of organism A processed material entity which is designed to be capable of a process. device