A collection is described as a group; its parts may also be separately described. See http://dublincore.org/documents/dcmi-type-vocabulary/#H7
Alters or influences an already existing condition, state, or situation.
Brings about a condition or an effect. Implied here is that an agent, such as for example, a pharmacologic substance or an organism, has brought about the effect. This includes induces, effects, evokes, and etiology.||||CA|caused_by.
Causes to become more severe or complex or results in adverse effects
Produces a direct effect on. Implied here is the altering or influencing of an existing condition, state, situation, or entity. This includes has a role in, alters, influences, predisposes, catalyzes, stimulates, regulates, depresses, impedes, enhances, contributes to, leads to, and modifies.
has a significant or salient relationship to.
The epistemic modality of an assertion. For now, this can only be 'positive' or 'negative'
A relation between an information content entity and a product that it (directly/indirectly) specifies
describes is a relation between one entity and another entity that it provides a description (detailed account of)
refers to is a relation between one entity and the entity that it makes reference to.
Typically an Annotation has a single Body (oa:hasBody), which is the comment or other descriptive resource, and a single Target (oa:hasTarget) that the Body is somehow 'about'. The Body provides the information which is annotating the Target. See http://www.w3.org/ns/oa#Annotation
A resource identifies part of another Source resource, a particular representation of a resource, a resource with styling hints for renders, or any combination of these. See http://www.w3.org/ns/oa#SpecificResource
A Selector that describes a textual segment by means of quoting it, plus passages before or after it. See http://www.w3.org/ns/oa#TextQuoteSelector
The relationship between a oa:SpecificResource and a oa:Selector. See http://www.w3.org/ns/oa#hasSelector
Fixed eruption due to iodide and antipyrine.
Drug-HOI body from MEDLINE PMID 13864141 using UMLS drug C0003420 (Antipyrine) and UMLS HOI C0151629 (Fixed eruption)
Ultraviolet-induced acantholysis was inhibited by chloroquine phosphate, taken orally, in the two patients tested.
tients having pemphigus was of subepidermal type.
Prednisone had no such effect. It is concluded th
Drug-HOI body from MEDLINE PMID 11850959 using UMLS drug C0055447 (chloroquine diphosphate) and UMLS HOI C0000887 (Acantholysis)
Drug-HOI body from MEDLINE PMID 13888438 using UMLS drug C0022209 (isoniazid) and UMLS HOI C0033941 (Psychoses, Substance-Induced)
Studies in the psychological effects of a new drug (diethylpropion).
Drug-HOI body from MEDLINE PMID 5341243 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C1306597 (Psychiatric problem)
Drug-HOI body from MEDLINE PMID 5341243 using UMLS drug C0012201 (Diethylpropion) and UMLS HOI C1306597 (Psychiatric problem)
Drug-HOI body from MEDLINE PMID 5234064 using UMLS drug C0028156 (Nitrofurantoin) and UMLS HOI C0022346 (Icterus)
Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin.
Drug-HOI body from MEDLINE PMID 5297151 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0333282 (Occult hemorrhage)
[Ocular complications caused by synthetic antimalarials].
Drug-HOI body from MEDLINE PMID 4221284 using UMLS drug C0003374 (Antimalarials) and UMLS HOI C0009566 (Complication)
Suppression of ectopic beats by ajmaline in a patient with artificial heart pacemaker.
Drug-HOI body from MEDLINE PMID 5666618 using UMLS drug C0001888 (Ajmaline) and UMLS HOI C0015374 (Ectopic beats)
Effect of thioridazine, amphetamine and placebo on the hyperkinetic syndrome and cognitive area in mentally deficient children.
Drug-HOI body from MEDLINE PMID 4864657 using UMLS drug C0039943 (Thioridazine) and UMLS HOI C1263846 (Attention deficit hyperactivity disorder)
[Clinical evaluation of the hypotensive effect of pargyline hydrochloride and methyclothiazide].
Drug-HOI body from MEDLINE PMID 5318105 using UMLS drug C0282289 (Pargyline Hydrochloride) and UMLS HOI C0857353 (Hypotensive)
Drug-HOI body from MEDLINE PMID 5318105 using UMLS drug C0025696 (Methyclothiazide) and UMLS HOI C0857353 (Hypotensive)
Reversible sterility induced by medroxyprogesterone injections.
Drug-HOI body from MEDLINE PMID 5324883 using UMLS drug C0746480 (MEDROXYPROGESTERONE INJECTION) and UMLS HOI C0678108 (Sterility)
Intramural hemorrhage of small intestine due to anticoagulants.
Drug-HOI body from MEDLINE PMID 5297869 using UMLS drug C0003280 (Anticoagulants) and UMLS HOI C0333285 (Intramural hemorrhage)
Drug-HOI body from MEDLINE PMID 5294939 using UMLS drug C0034417 (Quinine) and UMLS HOI C0032797 (Postpartum Hemorrhage)
[Paradoxical association of myelomatous osteolysis with intense hyperosteoidosis. Inverse sensitivity to vitamin D and prednisone].
Drug-HOI body from MEDLINE PMID 14416768 using UMLS drug C0042866 (Vitamin D) and UMLS HOI C0029435 (Osteolysis)
Drug-HOI body from MEDLINE PMID 14416768 using UMLS drug C0032952 (Prednisone) and UMLS HOI C0029435 (Osteolysis)
[Comparison of the clinical effect of short-term administration of Pondex, methylphenidate, and placebos in neuroses].
Drug-HOI body from MEDLINE PMID 4388629 using UMLS drug C0025810 (Methylphenidate) and UMLS HOI C0027932 (Neurotic Disorders)
"Differences in clinical effects of three phenothiazines in ""acute"" schizophrenia."
Drug-HOI body from MEDLINE PMID 5342391 using UMLS drug C0031436 (Phenothiazines) and UMLS HOI C0857501 (Acute schizophrenia)
[Antalgic and antigastritic role of benzyl alcohol in medicamentous digestive intolerance].
Drug-HOI body from MEDLINE PMID 5851987 using UMLS drug C0005100 (Benzyl Alcohol) and UMLS HOI C0277585 (Drug intolerance)
[Critical study of icterus caused by chlorpromazine].
Drug-HOI body from MEDLINE PMID 4287605 using UMLS drug C0008286 (Chlorpromazine) and UMLS HOI C0022346 (Icterus)
Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease.
Drug-HOI body from MEDLINE PMID 4862377 using UMLS drug C0023660 (Lidocaine) and UMLS HOI C0085612 (Ventricular arrhythmia)
[Further clinical-experimental studies on the question of central anticholinergic agent induced confusional states].
Drug-HOI body from MEDLINE PMID 4383293 using UMLS drug C0242896 (Anticholinergic Agents) and UMLS HOI C0009676 (Confusion)
[Influence of MAO inhibitors on psilocybine induced psychosis].
Drug-HOI body from MEDLINE PMID 5702524 using UMLS drug C0026457 (Monoamine Oxidase Inhibitors) and UMLS HOI C0036939 (Shared Paranoid Disorder)
A case of complete AV block produced by guanethidine.
Drug-HOI body from MEDLINE PMID 5638475 using UMLS drug C0018318 (Guanethidine) and UMLS HOI C0151517 (Complete atrioventricular block)
[Aplasia of the bone marrow due to dinitrophenol with complete remission followed by an acute leukosis].
Drug-HOI body from MEDLINE PMID 4220821 using UMLS drug C0012466 (Dinitrophenols) and UMLS HOI C0243065 (Aplasia, NOS)
[Quinine as a cause of fetal malformation].
Drug-HOI body from MEDLINE PMID 5836960 using UMLS drug C0034417 (Quinine) and UMLS HOI C0000768 (Congenital Abnormality)
Behavioral effects of diphenylhydantoin in severe psychiatric disorders.
Drug-HOI body from MEDLINE PMID 4862960 using UMLS drug C0031507 (Phenytoin) and UMLS HOI C0004936 (Mental disorders)
A double blind study of the effect of tranexamic acid in essential menorrhagia.
Drug-HOI body from MEDLINE PMID 4890296 using UMLS drug C0040613 (Tranexamic Acid) and UMLS HOI C0025323 (Menorrhagia)
Drug-HOI body from MEDLINE PMID 5947216 using UMLS drug C0006949 (Carbamazepine) and UMLS HOI C0151763 (Liver damage)
Recurrent rhabdomyolysis precipitated by alcohol: a case report with physiological and electron microscopic studies of skeletal muscle.
Drug-HOI body from MEDLINE PMID 5986704 using UMLS drug C0001962 (Ethanol) and UMLS HOI C0035410 (Rhabdomyolysis)
Salivary gland enlargement caused by sulfisoxazole.
Drug-HOI body from MEDLINE PMID 5838332 using UMLS drug C0038745 (Sulfisoxazole) and UMLS HOI C0020569 (Salivary gland hypertrophy NOS)
Jaundice caused by phenazopyridine hydrochloride.
Drug-HOI body from MEDLINE PMID 5953726 using UMLS drug C0700555 (Phenazopyridine hydrochloride) and UMLS HOI C0022346 (Icterus)
[Cardiac arrest caused by succinylcholine, resuscitated with success by trans-diaphragmatic massage].
Drug-HOI body from MEDLINE PMID 5857661 using UMLS drug C0038627 (Succinylcholine) and UMLS HOI C0018790 (Heart Arrest)
[Cutaneous necrosis due to anticoagulants].
Drug-HOI body from MEDLINE PMID 5858319 using UMLS drug C0003280 (Anticoagulants) and UMLS HOI C0151799 (Skin necrosis)
Toxic psychosis due to antiparkinsonian drugs.
Drug-HOI body from MEDLINE PMID 6029651 using UMLS drug C0003405 (Antiparkinson Agents) and UMLS HOI C0033941 (Psychoses, Substance-Induced)
Recurrent anaphylaxis caused by a misidentified drug.
Drug-HOI body from MEDLINE PMID 5643684 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0002792 (Anaphylaxis)
Experimental psychoses induced by benactyzine in alcoholics.
Drug-HOI body from MEDLINE PMID 5699594 using UMLS drug C0004962 (Benactyzine) and UMLS HOI C0871739 (Experimental Psychosis)
The dextro isomer of propranolol had no effect on the exercise tachycardia;
ter as the doses of the two drugs were increased.
I.C.I. 45763 reduced it to the same extent as pro
Drug-HOI body from MEDLINE PMID 4877600 using UMLS drug C0033497 (Propranolol) and UMLS HOI C0039231 (Tachycardia)
Metabolic and hypotensive effects of ethacrynic acid.
Drug-HOI body from MEDLINE PMID 5694972 using UMLS drug C0014963 (Ethacrynic Acid) and UMLS HOI C0857353 (Hypotensive)
Atrial flutter with 1:1 atrioventricular conduction precipitated by antazoline (antistine).
Drug-HOI body from MEDLINE PMID 4380999 using UMLS drug C0003143 (Antazoline) and UMLS HOI C0004239 (Atrial Flutter)
Drug-HOI body from MEDLINE PMID 4380999 using UMLS drug C0877926 (Antistine) and UMLS HOI C0004239 (Atrial Flutter)
[Papules with allergic suppuration caused by sensitization to meprobamate].
Drug-HOI body from MEDLINE PMID 13586124 using UMLS drug C0025386 (Meprobamate) and UMLS HOI C0038862 (Suppuration)
Drug-HOI body from MEDLINE PMID 5710474 using UMLS drug C0040613 (Tranexamic Acid) and UMLS HOI C0025323 (Menorrhagia)
Drug-HOI body from MEDLINE PMID 5844831 using UMLS drug C0008286 (Chlorpromazine) and UMLS HOI C0022346 (Icterus)
[The effect of beta receptor blocking agent on various cardiac arrhythmias].
Drug-HOI body from MEDLINE PMID 4166271 using UMLS drug C0001645 (Adrenergic beta-Antagonists) and UMLS HOI C0003811 (cardiac arrhythmia)
Metabolic and hypotensive effects of a new rauwolfia-thiazide combination.
Drug-HOI body from MEDLINE PMID 5789861 using UMLS drug C0541746 (Thiazides) and UMLS HOI C0857353 (Hypotensive)
In addition, the ability of the two drugs to produce respiratory depression was determined in six healthy volunteers.
orphine in 75 postsurgical patients is presented.
The results of these studies indicate that 0.2 mg
Drug-HOI body from MEDLINE PMID 4951240 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0235063 (Respiratory Depression)
In seven others alcohol alone did not cause gastrointestinal bleeding.
increased by alcohol in the 13 subjects studied.
These findings suggest that alcohol may accentuat
Drug-HOI body from MEDLINE PMID 5303551 using UMLS drug C0001962 (Ethanol) and UMLS HOI C0017181 (Gastrointestinal Hemorrhage)
Drug-HOI body from MEDLINE PMID 5938224 using UMLS drug C0008161 (Chloral Hydrate) and UMLS HOI C0151629 (Fixed eruption)
Drug-HOI body from MEDLINE PMID 4157308 using UMLS drug C0031436 (Phenothiazines) and UMLS HOI C0857353 (Hypotensive)
[Studies on the effects of a tranquilizer on emotionally unstable persons under various test conditions].
Drug-HOI body from MEDLINE PMID 5321303 using UMLS drug C0040614 (Tranquilizing Agents) and UMLS HOI C0338970 (Emotionally unstable personality disorder)
Quinine induced hypoplasia of the optic nerve.
Drug-HOI body from MEDLINE PMID 5977436 using UMLS drug C0034417 (Quinine) and UMLS HOI C0243069 (Hypoplasia)
[Anaphylactic shock caused by Droperidol and Pentazocine (author's transl)].
Drug-HOI body from MEDLINE PMID 7401292 using UMLS drug C0013136 (Droperidol) and UMLS HOI C0002792 (Anaphylaxis)
Drug-HOI body from MEDLINE PMID 7401292 using UMLS drug C0030873 (Pentazocine) and UMLS HOI C0002792 (Anaphylaxis)
Metabolism, anticholinergic effects, and therapeutic outcome of desmethylimipramine in depressive illness.
Drug-HOI body from MEDLINE PMID 4571142 using UMLS drug C0011685 (Desipramine) and UMLS HOI C0011581 (Depressive disorder)
Effect of oxprenolol on stage-fright in musicians.
Drug-HOI body from MEDLINE PMID 72290 using UMLS drug C0030040 (Oxprenolol) and UMLS HOI C0395003 (Stage fright)
A case is presented in which the recipient of a cadaveric renal allograft (zero antigen match, cross-match negative) was given ALS (first 14 days after operation) and 11 X 10(9) donor bone marrow cells (twenty-fifth postoperative day) along with conventional doses of prednisone and Imuran in an attempt to produce donor-specific immune unresponsiveness.
ntilymphocyte serum (ALS) for active enhancement.
There were no rejection episodes, and serum creat
Drug-HOI body from MEDLINE PMID 769219 using UMLS drug C0699279 (Imuran) and UMLS HOI C0020963 (Immune Tolerance)
Drug-HOI body from MEDLINE PMID 1101457 using UMLS drug C0010525 (Cyclandelate) and UMLS HOI C0497327 (Dementia)
Prolonged apnoea due to suxamethonium in Chinese.
Drug-HOI body from MEDLINE PMID 900467 using UMLS drug C0038627 (Succinylcholine) and UMLS HOI C0003578 (Apnea)
in its effect on the inflammatory edema of the skin, it stands between oxyphenbutazone and indomethacin.
effect on the inflammatory erythema of the skin;
Drug-HOI body from MEDLINE PMID 358658 using UMLS drug C0021246 (Indomethacin) and UMLS HOI C0522565 (Inflammatory edema)
Drug-HOI body from MEDLINE PMID 358658 using UMLS drug C0030078 (Oxyphenbutazone) and UMLS HOI C0522565 (Inflammatory edema)
Effect of aspirin on postoperative venous thrombosis.
Drug-HOI body from MEDLINE PMID 4115340 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0042487 (Venous Thrombosis)
Effects of naloxone on schizophrenia: reduction in hallucinations in a subpopulation of subjects.
Drug-HOI body from MEDLINE PMID 351804 using UMLS drug C0027358 (Naloxone) and UMLS HOI C0036341 (Schizophrenia)
Parasympathetic suppression of manic symptoms by physostigmine.
Drug-HOI body from MEDLINE PMID 4692153 using UMLS drug C0031849 (Physostigmine) and UMLS HOI C0746402 (MANIC SYMPTOM)
[Corneal lesions caused by cordarone (amiodarone).
Drug-HOI body from MEDLINE PMID 5080368 using UMLS drug C0701076 (Cordarone) and UMLS HOI C0151571 (Corneal lesion)
[Clinical contribution to the study on the effects of trazodone in conversion hysteria].
Drug-HOI body from MEDLINE PMID 338244 using UMLS drug C0040805 (Trazodone) and UMLS HOI C0009946 (Conversion disorder)
Total weekly blood loss was measured as 13.8 ml due to the treatment with indometacin and 6.5 ml due to acemetacin.
ficant difference (p < 0.001) between both drugs.
During the wash-out period blood loss was detecte
Drug-HOI body from MEDLINE PMID 6968220 using UMLS drug C0050409 (acemetacin) and UMLS HOI C0232100 (Exsanguination)
The clinical and psychological effects of pemoline were compared with placebo in a double-blind study of 20 depressed patients.
Target symptoms were disturbances of concentratio
Drug-HOI body from MEDLINE PMID 391753 using UMLS drug C0030800 (Pemoline) and UMLS HOI C1306597 (Psychiatric problem)
Letter: Psychosis associated with sympathomimetic and cromoglycate therapy.
Drug-HOI body from MEDLINE PMID 4213859 using UMLS drug C0039052 (Sympathomimetics) and UMLS HOI C0033975 (Psychotic Disorders)
Drug-HOI body from MEDLINE PMID 4213859 using UMLS drug C0010347 (Cromoglycate) and UMLS HOI C0033975 (Psychotic Disorders)
Effect of diethylcarbamazine pamoate upon exercise-induced obstruction in asthmatic children.
Drug-HOI body from MEDLINE PMID 4851628 using UMLS drug C1602232 (PAMOATE) and UMLS HOI C0028778 (Obstruction)
It is concluded that in this patient group, NAPA suppressed chronic ventricular ectopic complexes without adverse effects in only a minority of patients.
dose-dependent prolongation of the Q-Tc interval.
Drug-HOI body from MEDLINE PMID 6161534 using UMLS drug C0001061 (Acecainide) and UMLS HOI C0151636 (Ventricular Premature Complexes)
Aprindine probably played a decisive role in the fatal outcome of this complex drug intoxication.
secondary ventricular fibrillation and asystole.
Drug-HOI body from MEDLINE PMID 1087816 using UMLS drug C0003639 (Aprindine) and UMLS HOI C0206277 (Fatal Outcome)
Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes.
Drug-HOI body from MEDLINE PMID 4935344 using UMLS drug C0020616 (Hypoglycemic Agents) and UMLS HOI C0009566 (Complication)
[The effect of the beta-adrenergic blocking agent propranolol in mania (author's transl)].
Drug-HOI body from MEDLINE PMID 999494 using UMLS drug C0033497 (Propranolol) and UMLS HOI C0338831 (Manic)
This complication was possibly due to other medication.
urred in the patient who received dexpropranolol.
Other side-effects were insomnia, hypertension, p
Drug-HOI body from MEDLINE PMID 999494 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0009566 (Complication)
Methotrexate (MTX) has been implicated as a cause of interstitial pneumonitis and/or fibrosis, but the mechanism by which the drug causes these processes is not known.
The purpose of this study was to determine whethe
Drug-HOI body from MEDLINE PMID 440894 using UMLS drug C0025677 (Methotrexate) and UMLS HOI C0016059 (Fibrosis)
The purpose of this study was to determine whether patients receiving high-dose MTX developed a consistent decrease in pulmonary function, which would implicate a role for total dose of MTX received in the pathogenesis of the lung toxicity.
ich the drug causes these processes is not known.
Pulmonary function studies, including spirometry,
Drug-HOI body from MEDLINE PMID 440894 using UMLS drug C0025677 (Methotrexate) and UMLS HOI C0919924 (Pulmonary toxicity)
Recognition in adult patients of malformations induced by folic-acid antagonists.
Drug-HOI body from MEDLINE PMID 728558 using UMLS drug C0016411 (Folic Acid Antagonists) and UMLS HOI C0000768 (Congenital Abnormality)
Psychological effects of tetrahydrocannabinol.
Drug-HOI body from MEDLINE PMID 5410582 using UMLS drug C0039663 (Tetrahydrocannabinol) and UMLS HOI C1306597 (Psychiatric problem)
[Clinical and electroencephalographic studies of the effect of nicergoline in cerebrovascular diseases].
Drug-HOI body from MEDLINE PMID 4575428 using UMLS drug C0028008 (Nicergoline) and UMLS HOI C0007820 (Cerebrovascular Disorders)
Acute organic brain syndrome induced by disulfiram is not rare but is often not correlated, and it should always be considered a possibility in patients receiving disulfiram therapy.
ved ten days after discontinuation of disulfiram.
Drug-HOI body from MEDLINE PMID 472804 using UMLS drug C0012772 (Disulfiram) and UMLS HOI C0029221 (Organic brain syndrome)
[Allergic shock caused by trimecaine in prolonged peridural blockade].
Drug-HOI body from MEDLINE PMID 664161 using UMLS drug C0041026 (Trimecaine) and UMLS HOI C0002792 (Anaphylaxis)
In spontaneously breathing patients pentazocine causes ventilatory depression indicated by a decrease in PaO2 and an increase in PaCO2.
e group receiving the higher dose of pentazocine.
In these patients pulmonary vascular resistance a
Drug-HOI body from MEDLINE PMID 7468987 using UMLS drug C0030873 (Pentazocine) and UMLS HOI C0235063 (Respiratory Depression)
Fetal malformation due to phenobarbitone.
Drug-HOI body from MEDLINE PMID 424928 using UMLS drug C0031412 (Phenobarbital) and UMLS HOI C0000768 (Congenital Abnormality)
Hypersensitivity and jaundice due to azathioprine.
Drug-HOI body from MEDLINE PMID 7433331 using UMLS drug C0004482 (Azathioprine) and UMLS HOI C0022346 (Icterus)
Drug-HOI body from MEDLINE PMID 7433331 using UMLS drug C0004482 (Azathioprine) and UMLS HOI C0020517 (Hypersensitivity)
The results support the hypothesis that in certain pain situations, clomipramine exerts a beneficial effect, not only because of its effect on the depression and anxiety level of the patient, but also via its effects on the 5-HT brain system.
tic neuralgia. Clomipramine was better tolerated.
Drug-HOI body from MEDLINE PMID 489262 using UMLS drug C0009010 (Clomipramine) and UMLS HOI C0011581 (Depressive disorder)
As favouring or triggering factor, respectively, for the pathogenesis of the mediastinal emphysema in accordance with Macklin an increase of the intrathoracic pressure by retching, pressing or vomiting is regarded.
er patients revealed a long lasting malnutrition.
Apart from this a vasoconstriction of the alveola
Drug-HOI body from MEDLINE PMID 1210459 using UMLS drug C0309049 (FAVOR) and UMLS HOI C0025062 (Mediastinal Emphysema)
A trial of the efficacy of low-concentration nonmiotic therapy was carried out, the aim being to minimise the side effects produced by 1% adrenaline or pilocarpine.
A total of 77 eyes with open-angle glaucoma were
Drug-HOI body from MEDLINE PMID 7004478 using UMLS drug C0031923 (Pilocarpine) and UMLS HOI C0879626 (Adverse effects)
[Retroperitoneal fibrosis due to methysergide with compression of the ureters and iliac arteries (apropos of a case)].
Drug-HOI body from MEDLINE PMID 5054761 using UMLS drug C0025842 (Methysergide) and UMLS HOI C0035357 (Retroperitoneal fibrosis)
Effects of perhexiline maleate on exercise-induced tachycardia.
Drug-HOI body from MEDLINE PMID 4917353 using UMLS drug C0070413 (perhexiline maleate) and UMLS HOI C0039231 (Tachycardia)
Drug-HOI body from MEDLINE PMID 335383 using UMLS drug C0700921 (ICI-66082) and UMLS HOI C0857353 (Hypotensive)
The hyperventilatory response to hypoxia was not altered by propranolol.
propranolol, a beta adrenergic receptor blocker.
Intravenous infusion of phenylephrine caused a sm
Drug-HOI body from MEDLINE PMID 4336940 using UMLS drug C0033497 (Propranolol) and UMLS HOI C0242184 (Hypoxia)
Ticrynafen appears to be an effective antihypertensive with a substantial hypouricemic effect.
cal adverse effects to either of the medications.
Drug-HOI body from MEDLINE PMID 348380 using UMLS drug C0040209 (Ticrynafen) and UMLS HOI C0221333 (Hypouricemia)
Halofenate had a greater hypouricemic effect than clofibrate and may be a useful drug for treatment of patients with Type IV hyperlipoproteinemia who have concomitant hyperuricemia.
sitive correlation with that on uric acid levels.
Drug-HOI body from MEDLINE PMID 797258 using UMLS drug C0018541 (Halofenate) and UMLS HOI C0221333 (Hypouricemia)
The effect of beta adrenergic blocking agents on the renin release from the kidney and its possible role in the hypotensive effect of these agents were studied in patients with essential hypertension.
Oxprenolol induced a significant decrease in syst
Drug-HOI body from MEDLINE PMID 22466 using UMLS drug C0001645 (Adrenergic beta-Antagonists) and UMLS HOI C0857353 (Hypotensive)
The motor block from plain etidocaine was more profound in its extent and lasted longer than that caused by lignocaine.
dermatomes than did 2% lignocaine hydrochloride.
With regard to cardiovascular variables, there we
Drug-HOI body from MEDLINE PMID 786348 using UMLS drug C0023660 (Lidocaine) and UMLS HOI C0028778 (Obstruction)
The side-effects produced by the two drugs were similar, as were the effect on respiratory and cardiovascular measurements.
and appeared to have a longer duration of action.
Drug-HOI body from MEDLINE PMID 338392 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0879626 (Adverse effects)
In the absence of autonomic blocking drugs, THC produced characteristic tachycardia, subjective intoxication, and EEG effects.
time productions, and EEG activity were measured.
After combined autonomic blockade, THC had no eff
Drug-HOI body from MEDLINE PMID 108734 using UMLS drug C0039663 (Tetrahydrocannabinol) and UMLS HOI C0039231 (Tachycardia)
No adverse effects attributable to flunisolide were observed.
l of their nasal symptoms in the 6 wk open study.
Parameters of IgE-mediated reactivity, including
Drug-HOI body from MEDLINE PMID 7350203 using UMLS drug C0060501 (flunisolide) and UMLS HOI C0879626 (Adverse effects)
Vascular changes and multiple thromboses induced by fibrinogen infusions and contraceptive medication.
Drug-HOI body from MEDLINE PMID 5550548 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0040053 (Thrombosis)
Hypotensive effects of clonidine and chlorthalidone.
Drug-HOI body from MEDLINE PMID 4935613 using UMLS drug C0009014 (Clonidine) and UMLS HOI C0857353 (Hypotensive)
Drug-HOI body from MEDLINE PMID 4935613 using UMLS drug C0008294 (Chlorthalidone) and UMLS HOI C0857353 (Hypotensive)
Drug-HOI body from MEDLINE PMID 980029 using UMLS drug C0027396 (Naproxen) and UMLS HOI C0022346 (Icterus)
Also, after 3 weeks of treatment with methylphenidate, guinea pigs showed a hypersensitive response to apomorphine, suggesting that chronic administration of methylphenidate leads to hypersensitivity of receptor sites.
of the drug on central catecholaminergic systems.
Chorea beginning shortly after initiation of meth
Drug-HOI body from MEDLINE PMID 570658 using UMLS drug C0025810 (Methylphenidate) and UMLS HOI C0020517 (Hypersensitivity)
Hydroxyurea has been rarely implicated as a cause of drug fever.
In this report, we describe a patient who was hig
Drug-HOI body from MEDLINE PMID 7458524 using UMLS drug C0020402 (hydroxyurea) and UMLS HOI C0235724 (Drug fever)
Ketamine was found to reduce early mortality principally by a reduction in thromboembolic complications, but at the expense of more unsatisfactory surgical results.
ons for fractured neck of femur in elderly women.
It is suggested that the mortality after relaxant
Drug-HOI body from MEDLINE PMID 7386839 using UMLS drug C0022614 (Ketamine) and UMLS HOI C0009566 (Complication)
In addition the use of metoprolol abolished the ventricular premature beats in 9 cases, while in two cases there was an increase of their frequency.
of the ventricular premature beats of the 51.2%.
In the 14 patients with chronic atrial fibrillati
Drug-HOI body from MEDLINE PMID 6989699 using UMLS drug C0025859 (Metoprolol) and UMLS HOI C0151636 (Ventricular Premature Complexes)
Pruritus of pregnancy and jaundice induced by oral contraceptives.
Drug-HOI body from MEDLINE PMID 1274944 using UMLS drug C0009905 (Contraceptives, Oral) and UMLS HOI C0022346 (Icterus)
This study indicates that the single-solution regimens used in intravenous nutrition caused no adverse metabolic effects and was used as efficiently as a conventional regimen in the early postoperative period.
al parenteral nutrition decreased in both groups.
Drug-HOI body from MEDLINE PMID 6789665 using UMLS drug C0357168 (Intravenous nutrition) and UMLS HOI C0879626 (Adverse effects)
The effects of aspirin on delayed hypersensitivity were assessed in 40 healthy subjects who were randomly assigned to two equal groups.
In a double-blind format, the individuals in one
Drug-HOI body from MEDLINE PMID 332184 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0020522 (Delayed Hypersensitivity)
[Acute liver insufficiency caused by rifampicin-isoniazid].
Drug-HOI body from MEDLINE PMID 7402379 using UMLS drug C0358905 (Rifampicin+isoniazid) and UMLS HOI C1306571 (Hepatic Insufficiency)
Although the hypotensive effects of methyldopa were more marked than tolamolol, these only achieved conventional (P less than 0.05) levels of significance for lying blood pressure.
standing, systolic and diastolic blood pressures.
There were no objective changes in haematological
Drug-HOI body from MEDLINE PMID 323023 using UMLS drug C0076790 (tolamolol) and UMLS HOI C0857353 (Hypotensive)
A 16-day-old breast-fed infant with metabolic acidosis caused by salicylate.
Drug-HOI body from MEDLINE PMID 7449246 using UMLS drug C0036075 (salicylate) and UMLS HOI C0220981 (Metabolic acidosis)
Long-term and short-term effects of oral prethcamide in chronic ventilatory failure.
Drug-HOI body from MEDLINE PMID 4913786 using UMLS drug C0071957 (prethcamide) and UMLS HOI C0231178 (Chronic failure)
A 34-year-old white woman who had used oral contraceptives for six years showed an occlusive bilateral retinal arteriolitis that resulted in a branch arteriolar occlusion in the right eye and retinal neovascularization.
Three years later, we observed active arterioliti
Drug-HOI body from MEDLINE PMID 1275035 using UMLS drug C0009905 (Contraceptives, Oral) and UMLS HOI C0028778 (Obstruction)
The suppression of stage 4 night terrors with diazepam.
Drug-HOI body from MEDLINE PMID 4346185 using UMLS drug C0012010 (Diazepam) and UMLS HOI C0037320 (Night Terrors)
A patient is reported in whom an intravenous bolus injection of 50 mg lignocaine produced extreme sinus bradycardia (rate 14 to 20/min).
Only 2 patients with such a response to a similar
Drug-HOI body from MEDLINE PMID 808233 using UMLS drug C0023660 (Lidocaine) and UMLS HOI C0085610 ([D]Sinus bradycardia)
The administration of neuroleptic drugs favourably influenced the psychosis, which disappeared with a final depressive stage, thereby enabling removal of the second hyperplastic adrenal gland.
hallucinosis with imperative voices was observed.
The physical signs showed a good remission, excep
Drug-HOI body from MEDLINE PMID 1226764 using UMLS drug C0040615 (Antipsychotic Agents) and UMLS HOI C0033975 (Psychotic Disorders)
Influence of isoniazid on naturally acquired tuberculin allergy and on induction of allergy by BCG vaccination.
Drug-HOI body from MEDLINE PMID 5312322 using UMLS drug C0022209 (isoniazid) and UMLS HOI C0570560 (Tuberculin allergy)
To investigate the antagonistic effect of naloxone on fentanyl-induced respiratory depression, 55 patients (randomly divided into various study and control groups were studied during nitrous-oxide-oxygen-halothane anaesthesia. Respiratory depression after 0.1 mg of fentanyl was totally reversed by 10 microgram/kg of naloxone, measured as 100% restoration of spontaneous respiration, normal minute volume and end-tidal CO2, while 15 microgram/kg of naloxone was needed to antagonize 0.2 mg of fentanyl. The respective control groups remained apnoeic. If no fentanyl had previously been administered, there was no difference in the respiratory behaviour of naloxone-treated and control patients, which indicates that no unspecific analeptic effect of naloxone could be demonstrated. The circulatory changes after fentanyl were nearly reversed by naloxone, as has been found earlier with other narcotics. Recovery from anaesthesia was scored from 0 to 10 (using a modification of Apgar scores for new
borns), and somewhat higher mean scores were obtai
Drug-HOI body from MEDLINE PMID 605761 using UMLS drug C0027358 (Naloxone) and UMLS HOI C0235063 (Respiratory Depression)
After moderate doses of fentanyl during balanced anaesthesia, routine use of naloxone does not seem to be necessary, but if rapid recovery is essential, 1.0 microgram/kg i.v. or 2.5 microgram/kg i.m. of naloxone may be recommended and these doses do not cause a higher incidence of side effects.
icrogram/kg im. of naloxone than in other groups.
Drug-HOI body from MEDLINE PMID 605762 using UMLS drug C0027358 (Naloxone) and UMLS HOI C0879626 (Adverse effects)
nt and severe in those treated with furazolidone.
Drug-HOI body from MEDLINE PMID 869108 using UMLS drug C0040263 (Tinidazole) and UMLS HOI C0879626 (Adverse effects)
Clinical evaluation of clobetasone butyrate: a comparative study of its effects in postoperative inflammation and on intraocular pressure.
Drug-HOI body from MEDLINE PMID 6986899 using UMLS drug C0055896 (clobetasone butyrate) and UMLS HOI C0021368 (Inflammation)
A double-blind, randomized, crossover trial was carried out in 26 hypertensive patients to investigate the hypotensive effects of three different dosages of frusemide (40 mg, 60 mg, and 80 mg twice daily) and the effects on serum potassium and urinary output.
The study included a 4-week treatment period with
Drug-HOI body from MEDLINE PMID 7001489 using UMLS drug C0016860 (Furosemide) and UMLS HOI C0857353 (Hypotensive)
The effects of naloxone in chronic schizophrenia.
Drug-HOI body from MEDLINE PMID 6266259 using UMLS drug C0027358 (Naloxone) and UMLS HOI C0221765 (Chronic schizophrenia)
Treated mania exacerbated by bromocriptine.
Drug-HOI body from MEDLINE PMID 7196160 using UMLS drug C0006230 (Bromocriptine) and UMLS HOI C0338831 (Manic)
Although anticholinergic drugs are not very extensively used, SCH 1000 may be useful in some patients where the beta 2 adrenergic drugs cause signficant side effects or are contraindicated.
enoterol depended on the exercise response alone.
Drug-HOI body from MEDLINE PMID 6447269 using UMLS drug C0001637 (Adrenergic Agents) and UMLS HOI C0879626 (Adverse effects)
Complete V-A block (without impairment of forward conduction) produced by propranolol.
Drug-HOI body from MEDLINE PMID 5088776 using UMLS drug C0033497 (Propranolol) and UMLS HOI C0028778 (Obstruction)
Naproxen sodium also induced less gastrointestinal bleeding and caused fewer side effects than aspirin.
with gastric pathology following naproxen sodium.
Drug-HOI body from MEDLINE PMID 7240438 using UMLS drug C0546873 (Naproxen sodium) and UMLS HOI C0017181 (Gastrointestinal Hemorrhage)
[Anaphylactic shock caused by hydroxocobalamin].
Drug-HOI body from MEDLINE PMID 135965 using UMLS drug C0020316 (Hydroxocobalamin) and UMLS HOI C0002792 (Anaphylaxis)
This effect of diazepam on contraction frequency was additional to its tranquilizing and muscle relaxant action.
on frequency. No effect on uterine tone was seen.
Drug-HOI body from MEDLINE PMID 338552 using UMLS drug C0012010 (Diazepam) and UMLS HOI C1140999 (Contraction)
A double blind, cohort, prospective, randomized study was set up comparing Valium and Serax in their antianxiety qualities and their tendency to produce increased aggression and paradoxical rage reactions.
y and aggressive tendencies in these individuals.
Guidelines are proposed for the use of benzodiaze
Drug-HOI body from MEDLINE PMID 24618 using UMLS drug C0702214 (Serax) and UMLS HOI C0001807 (Aggressive behavior)
The effect of intravenous acebutolol on supraventricular arrhythmias was evaluated in 20 patients, 5 with chronic obstructive pulmonary disease.
A rapid ventricular rate in atrial fibrillation w
Drug-HOI body from MEDLINE PMID 365429 using UMLS drug C0000946 (Acebutolol) and UMLS HOI C0428974 (Supraventricular arrhythmia)
Despite its comparable hypotensive effect in normal subjects, continuous delivery of pilocarpine by means of an ocular therapeutic system elicits less severe side effects than pilocarpine eyedrops.
dicaps that were not correctable with spectacles.
Drug-HOI body from MEDLINE PMID 1101690 using UMLS drug C0031923 (Pilocarpine) and UMLS HOI C0857353 (Hypotensive)
Significantly greater tachycardia was produced by 0.5% isoprenaline than by the same concentration of salbutamol.
lator effect occurred earlier after isoprenaline.
The 0.25, 0.5, and 1% concentrations of salbutamo
Drug-HOI body from MEDLINE PMID 4921234 using UMLS drug C0022245 (Isoproterenol) and UMLS HOI C0039231 (Tachycardia)
Under these circumstances, enflurane produced significantly fewer dysrhythmias than halothane, but was a more difficult, more expensive and less versatile agent to use.
livered from paired Goldman vaporisers in series.
Overall, it was considered inferior to halothane
Drug-HOI body from MEDLINE PMID 7020472 using UMLS drug C0014277 (Enflurane) and UMLS HOI C0003811 (cardiac arrhythmia)
Emergency room management of organic brain syndromes caused by over-the-counter hypnotics.
Drug-HOI body from MEDLINE PMID 831019 using UMLS drug C0020591 (Hypnotics) and UMLS HOI C0029221 (Organic brain syndrome)
[Double blind test for induction of uterine hemorrhage by Ovulen (ethynodiol diacetate 0.5mg+mestranol 1.1mg])].
Drug-HOI body from MEDLINE PMID 4917962 using UMLS drug C0950380 (Ovulen) and UMLS HOI C0042134 (Uterine hemorrhage)
The difficulties in diagnosing such reactions and in determining the drug responsible and how these difficulties have led to confusion in the literature are discussed.
incidence is rare, but appears to be increasing.
Six cases of severe histamine mediated reactions
Drug-HOI body from MEDLINE PMID 52304 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0009676 (Confusion)
Ventricular arrhythmias caused by prenylamine.
Drug-HOI body from MEDLINE PMID 902000 using UMLS drug C0033059 (Prenylamine) and UMLS HOI C0085612 (Ventricular arrhythmia)
[Blind study of lorazepam and diazepam in preanesthetic medication: evaluation of the ability to produce amnesia and sedation].
Drug-HOI body from MEDLINE PMID 6107986 using UMLS drug C0012010 (Diazepam) and UMLS HOI C0002622 (Amnesia)
Drug-HOI body from MEDLINE PMID 6107986 using UMLS drug C0024002 (Lorazepam) and UMLS HOI C0002622 (Amnesia)
Severe cerebral confusion produced by prajmalium bitartrate.
Drug-HOI body from MEDLINE PMID 902048 using UMLS drug C0032901 (Prajmalium Bitartrate) and UMLS HOI C0009676 (Confusion)
Sulfasalazine, a drug common in the treatment of inflammatory bowel disease, may cause liver damage.
We present a patient with documented granulomatou
Drug-HOI body from MEDLINE PMID 6113258 using UMLS drug C0036078 (Sulfasalazine) and UMLS HOI C0151763 (Liver damage)
Since tricyclic antidepressants are known to exacerbate psychosis in schizophrenic patients, it is sometimes suggested that the exacerbation of psychotic thinking in depressed patients indicates schizophrenia.
de and had no evidence of schizophrenia or mania.
The authors suggest that such an exacerbation doe
Drug-HOI body from MEDLINE PMID 426146 using UMLS drug C0003290 (Antidepressive Agents, Tricyclic) and UMLS HOI C0033975 (Psychotic Disorders)
Large and frequent doses of quinidine, procainamide, disopyramide, propranolol, and digoxin failed to suppress his arrhythmias.
tachycardia, and atrial flutter and fibrillation.
He had no previous history of myocardial infarcti
Drug-HOI body from MEDLINE PMID 7418495 using UMLS drug C0033497 (Propranolol) and UMLS HOI C0003811 (cardiac arrhythmia)
Drug-HOI body from MEDLINE PMID 7418495 using UMLS drug C0012702 (Disopyramide) and UMLS HOI C0003811 (cardiac arrhythmia)
Drug-HOI body from MEDLINE PMID 7418495 using UMLS drug C0033216 (Procainamide) and UMLS HOI C0003811 (cardiac arrhythmia)
A new antiarrhythmic drug, lorcainide, was given intravenously and it suppressed all PVCs, including bigeminy and ventricular tachycardia.
truction of any major arteries or their branches.
All his arrhythmias have been completely suppress
Drug-HOI body from MEDLINE PMID 7418495 using UMLS drug C0065183 (lorcainide) and UMLS HOI C0151636 (Ventricular Premature Complexes)
Drug-HOI body from MEDLINE PMID 7418495 using UMLS drug C0065183 (lorcainide) and UMLS HOI C0042514 (Tachycardia, Ventricular)
In the other patient, who had rheumatoid arthritis, rechallenge with salicylate evoked hepatic dysfunction and recurrent symptoms.
hematosus and drug rechallenge was not attempted.
Salicylate-induced liver injury should be conside
Drug-HOI body from MEDLINE PMID 838229 using UMLS drug C0036075 (salicylate) and UMLS HOI C0086565 (Liver Dysfunction)
No clinical side-effects were attributable to furosemide, but the small size of the group does not permit any definitive conclusions about this aspect.
use in a larger regional surveillance programme.
Drug-HOI body from MEDLINE PMID 729629 using UMLS drug C0016860 (Furosemide) and UMLS HOI C0879626 (Adverse effects)
The effect of papaverine on the contraction of the human gallbladder.
Drug-HOI body from MEDLINE PMID 649240 using UMLS drug C0030350 (Papaverine) and UMLS HOI C1140999 (Contraction)
[Long-term study on gastrointestinal hemorrhage due to acetylsalicylic acid].
Drug-HOI body from MEDLINE PMID 4998637 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0017181 (Gastrointestinal Hemorrhage)
Drug-HOI body from MEDLINE PMID 4779010 using UMLS drug C0074580 (sirepar) and UMLS HOI C0002792 (Anaphylaxis)
Phenothiazine effects on psychological and psychophysiological dysfunction in chronic schizophrenics.
Drug-HOI body from MEDLINE PMID 326215 using UMLS drug C0031434 (phenothiazine) and UMLS HOI C1306597 (Psychiatric problem)
Drug-HOI body from MEDLINE PMID 326215 using UMLS drug C0031434 (phenothiazine) and UMLS HOI C0033931 (Psychophysiologic Disorders)
[The effect of Reparil on post-traumatic oedema].
Drug-HOI body from MEDLINE PMID 5108975 using UMLS drug C0936220 (Reparil) and UMLS HOI C0013604 (Edema)
Violence associated with chronic phencyclidine (PCP) abuse was investigated by administering a structured interview to 16 chronic PCP abusers.
A more intensive study was done of another indivi
Drug-HOI body from MEDLINE PMID 507211 using UMLS drug C0031381 (Phencyclidine) and UMLS HOI C0042693 (Violence)
Levamisole as given does not appear to have a major influence on delayed cutaneous hypersensitivity.
incidence of conversion to a DNCB reactive state.
Drug-HOI body from MEDLINE PMID 6985836 using UMLS drug C0023556 (Levamisole) and UMLS HOI C0020522 (Delayed Hypersensitivity)
Suppression of ventricular arrhythmias with intravenous disopyramide and lidocaine: efficacy comparison in a randomized trial.
Drug-HOI body from MEDLINE PMID 474432 using UMLS drug C0012702 (Disopyramide) and UMLS HOI C0085612 (Ventricular arrhythmia)
Drug-HOI body from MEDLINE PMID 474432 using UMLS drug C0023660 (Lidocaine) and UMLS HOI C0085612 (Ventricular arrhythmia)
During our observations there were no side effects or allergic reactions caused by pipecurium bromide.
a the effect can be antagonized with neostigmine.
Drug-HOI body from MEDLINE PMID 6248083 using UMLS drug C0206049 (Pipecuronium Bromide) and UMLS HOI C1527304 (Allergic Reaction)
The chief complaints included: (1) shortness of breath during sexual intercourse, (2) difficulty in oral foreplay, (3) poor verbal communication, (4) altered self-image, (5) sexual dysfunctions induced by pain medication, (6) depression, and (7) a lack of ability to exercise oral-genital sexual contact.
atients, and many of their problems were similar.
Nine of the ten patients agreed that the operatin
Drug-HOI body from MEDLINE PMID 280845 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0033953 (Psychosexual Disorders)
The clinical improvement with antibiotics such as metronidazole or with restitution of normal bowel continuity indicates that the bacterial flora in the excluded small bowel segment or its byproducts are causally related to the systemic complications.
response as a common factor in the pathogenesis.
Hyperoxaluria may be primarily the sequela of ste
Drug-HOI body from MEDLINE PMID 831442 using UMLS drug C0025872 (Metronidazole) and UMLS HOI C0009566 (Complication)
Two cases of adverse sequelae associated with the use of 2.5% thiopentone are reported: one involved extensive local venous thrombosis at the site of the injection causing great distress to the patient;
the other involved a histaminoid reaction in a pa
Drug-HOI body from MEDLINE PMID 665951 using UMLS drug C0039925 (Thiopental) and UMLS HOI C0042487 (Venous Thrombosis)
A case of rhabdomyolysis associated with suxamethonium.
Drug-HOI body from MEDLINE PMID 665991 using UMLS drug C0038627 (Succinylcholine) and UMLS HOI C0035410 (Rhabdomyolysis)
Glycopyrrolate produced less tachycardia, pyrexia and blurred vision than atropine, and its sedative effect was less than that of hyoscine.
alogogue actions of the three drugs were similar.
Drug-HOI body from MEDLINE PMID 7387805 using UMLS drug C0017970 (Glycopyrrolate) and UMLS HOI C0039231 (Tachycardia)
3 Both flurbiprofen and aspirin did not produce any apparent adverse effects on blood loss during the menstrual period.
and placebo in these patients with dysmenorrhoea.
4 In conclusion, the analgesic effect of flurbipr
Drug-HOI body from MEDLINE PMID 6992824 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0879626 (Adverse effects)
Drug-HOI body from MEDLINE PMID 6992824 using UMLS drug C0016377 (Flurbiprofen) and UMLS HOI C0879626 (Adverse effects)
Anaphylactic shock caused by yellow dye (FD & C No. 5 and FD & C No. 6) in an enema (case report).
Drug-HOI body from MEDLINE PMID 666064 using UMLS drug C1509750 (YELLOW DYE) and UMLS HOI C0002792 (Anaphylaxis)
Although tolamolol abolished the stress-induced tachycardia, it had no beneficial behavioural or subjective effects.
ther tolamolol 200 mg, diazepam 10 mg or placebo.
In contrast, diazepam, which had no significant e
Drug-HOI body from MEDLINE PMID 6894099 using UMLS drug C0076790 (tolamolol) and UMLS HOI C0039231 (Tachycardia)
Pentobarbital, 50 and 150 mg, produced respiratory depression, as did pentazocine, 30 mg intramuscularly.
pared to those of pentobarbital and pentazocine.
Lorazepam at 1.33 and 4 mg intramuscularly produ
Drug-HOI body from MEDLINE PMID 239807 using UMLS drug C0030883 (Pentobarbital) and UMLS HOI C0235063 (Respiratory Depression)
The hypotonic effect of glucagon (2 mg) and propantheline bromide (Pro-Banthine, 30 mg) on the upper gastrointestinal tract was compared in a double-blind study in 12 healthy volunteers and 36 patients.
The solvent solution for the two drugs was used a
Drug-HOI body from MEDLINE PMID 401600 using UMLS drug C0033448 (Propantheline Bromide) and UMLS HOI C0241938 (hypotonicity)
Drug-HOI body from MEDLINE PMID 401600 using UMLS drug C0728760 (Probanthine) and UMLS HOI C0241938 (hypotonicity)
Drug-HOI body from MEDLINE PMID 4246994 using UMLS drug C0010547 (Cyclizine) and UMLS HOI C0221242 (Fixed drug eruption)
Suxamethonium did not provoke ventricular ectopies or conduction disturbances.
ences was found in the group given suxamethonium.
It is concluded that in anesthesia with barbitura
Drug-HOI body from MEDLINE PMID 442947 using UMLS drug C0038627 (Succinylcholine) and UMLS HOI C0151636 (Ventricular Premature Complexes)
Drug-HOI body from MEDLINE PMID 442947 using UMLS drug C0038627 (Succinylcholine) and UMLS HOI C0232219 (Abnormal cardiac conduction)
Diazepam failed to produce amnesia in about 33% of the patients.
the difference was not statistically significant.
Thiopentone is suitable and pleasant for cardiove
Drug-HOI body from MEDLINE PMID 56946 using UMLS drug C0012010 (Diazepam) and UMLS HOI C0002622 (Amnesia)
This could be due to the fact that the Nitrosoureas produce a diffuse block of cellular activity, both at the nucleous and cytoplasm;
less of the patient's tumor response to the drug.
while other compounds act as alkylating agents or
Drug-HOI body from MEDLINE PMID 64132 using UMLS drug C0028210 (Nitrosourea Compounds) and UMLS HOI C0028778 (Obstruction)
Although producing considerable sedation, chlorpromazine did little to alter the underlying mania qualitatively.
t improvement of manic symptoms without sedation.
Qualitative differences between lithium carbonate
Drug-HOI body from MEDLINE PMID 1089401 using UMLS drug C0008286 (Chlorpromazine) and UMLS HOI C0338831 (Manic)
The sulfonylurea hypoglycemic agent tolazamide is thought to be a rare cause of jaundice and to exhibit no hepatic cross-sensitivity with other sulfonylurea compounds.
We have described a patient who had self-limited
Drug-HOI body from MEDLINE PMID 7403921 using UMLS drug C0040372 (Tolazamide) and UMLS HOI C0022346 (Icterus)
As platelet MAO was significantly stronger (p less than 0.001) inhibited in the (+)-TCP group as compared with the (-)-TCP group, it is suggested that MAO inhibition rather than uptake blockade is the biochemical mechanism responsible for both the antidepressant activity and the autonomic side effects due to TCP medication.
unced (p less than 0.05) in the (+)-isomer group.
Drug-HOI body from MEDLINE PMID 7017068 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0879626 (Adverse effects)
Drug-HOI body from MEDLINE PMID 7017068 using UMLS drug C0040778 (Tranylcypromine) and UMLS HOI C0879626 (Adverse effects)
When a patient shows a minor intolerance to the drug, the dose should be reduced to the one that controls the symptoms incompletely but produces no adverse effects.
cation, side-effects and complications may occur.
As the patient acquires greater tolerance the dos
Drug-HOI body from MEDLINE PMID 1063041 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0879626 (Adverse effects)
[Clinical results of the phenylephrine, isoprenaline, and atropine association in the treatment of obstructive respiratory insufficiency].
Drug-HOI body from MEDLINE PMID 4551951 using UMLS drug C0031469 (Phenylephrine) and UMLS HOI C0035229 (Respiratory Insufficiency)
Drug-HOI body from MEDLINE PMID 4551951 using UMLS drug C0004259 (Atropine) and UMLS HOI C0035229 (Respiratory Insufficiency)
Drug-HOI body from MEDLINE PMID 4551951 using UMLS drug C0022245 (Isoproterenol) and UMLS HOI C0035229 (Respiratory Insufficiency)
[Letter: Cholostatic jaundice caused by carbimazole].
Drug-HOI body from MEDLINE PMID 4800427 using UMLS drug C0006983 (Carbimazole) and UMLS HOI C0022346 (Icterus)
In no case did the drug lead to any side-effects.
n reducing the pain symptoms as well (p < 0.005).
Drug-HOI body from MEDLINE PMID 6998794 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0879626 (Adverse effects)
As far as is known, no direct carcinogenic effect can be ascribed to the two antimetabolites, but it must be assumed that these two drugs, taken by the patient for over seven years, led to cirrhosis of the liver whose malignant transformation was significantly influenced by the immunosuppressive effects of methotrexate and 6-mercaptopurine, given as maintenance therapy according to protocol 02 LA 64, Paris.
urse, still in complete haematological remission.
Drug-HOI body from MEDLINE PMID 169114 using UMLS drug C0003376 (Antimetabolites) and UMLS HOI C0016059 (Fibrosis)
In these postdelivery ambulant patients pentazocine 50 mg and tilidine 100 mg produced at 25% incidence of side-effects, mainly dizziness and drowsiness, but tilidine 25 mg produced significant analgesia with virtually no side-effects.
lts were not, however, statistically significant.
Drug-HOI body from MEDLINE PMID 335771 using UMLS drug C1383713 (Tilidine 100 MG) and UMLS HOI C0879626 (Adverse effects)
Drug-HOI body from MEDLINE PMID 335771 using UMLS drug C1123306 (Pentazocine 50 MG) and UMLS HOI C0879626 (Adverse effects)
The uricosuric/hypouricaemic effect of tienilic acid could assume clinical relevance in long-term therapy of hypertensive patients.
ic acid and hydrochlorothiazide are very similar.
Drug-HOI body from MEDLINE PMID 396083 using UMLS drug C0040209 (Ticrynafen) and UMLS HOI C0221333 (Hypouricemia)
Ventricular tachycardia with torsade de pointes morphology induced by oral disopyramide.
Drug-HOI body from MEDLINE PMID 7404173 using UMLS drug C0360693 (Oral form disopyramide) and UMLS HOI C0042514 (Tachycardia, Ventricular)
Effect of atropine on isorhythmic A-V dissociation.
Drug-HOI body from MEDLINE PMID 5277438 using UMLS drug C0004259 (Atropine) and UMLS HOI C0149788 (Atrioventricular dissociation)
Clinical studies of drugs that inhibit platelet aggregation have been reported to show a beneficial effect in preventing cardiac deaths or myocardial infarction;
been found to have abnormally reactive platelets.
other studies have been negative or shown only a
Drug-HOI body from MEDLINE PMID 35967 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0376297 (Cardiac Death)
Effects of beta adrenergic blockade with sotalol in chronic anxiety.
Drug-HOI body from MEDLINE PMID 4572800 using UMLS drug C0037707 (Sotalol) and UMLS HOI C0581386 (Chronic anxiety)
The effects of methylphenidate on early infantile autism and its relation to serum serotonin levels.
Drug-HOI body from MEDLINE PMID 608662 using UMLS drug C0025810 (Methylphenidate) and UMLS HOI C0004352 (Autistic Disorder)
Arginine-induced hyperglucagonemia is not suppressed by sulphonylureas.
emia is followed by a reactive hyperglucagonemia.
While there exists no difference between tolbutam
Drug-HOI body from MEDLINE PMID 811925 using UMLS drug C0038766 (Sulfonylurea Compounds) and UMLS HOI C0342218 (Excessive glucagon secretion)
A comparison of some physiological and psychological effects of Motival (fluphenazine and nortriptyline) and diazepam in normal subjects.
Drug-HOI body from MEDLINE PMID 619948 using UMLS drug C0066828 (Motival) and UMLS HOI C1306597 (Psychiatric problem)
Metabolic acidosis produced by vasopressors.
Drug-HOI body from MEDLINE PMID 7404289 using UMLS drug C0042397 (Vasoconstrictor Agents) and UMLS HOI C0220981 (Metabolic acidosis)
The administration of a vasopressor in the presence of hypovolemia results in a severe acidosis which may be fatal if continued.
Drug-HOI body from MEDLINE PMID 7404289 using UMLS drug C0042397 (Vasoconstrictor Agents) and UMLS HOI C0001122 (Acidosis)
The drug combination did not induce more sedation or gastrointestinal side effects than either drug alone.
than that of paracetamol or mephenoxalone alone.
Drug-HOI body from MEDLINE PMID 786667 using UMLS drug C0013162 (Drug Combinations) and UMLS HOI C0879626 (Adverse effects)
Dose-related tachycardia induced by pancuronium during balanced anaesthesia with and without droperidol.
Drug-HOI body from MEDLINE PMID 426993 using UMLS drug C0030310 (Pancuronium) and UMLS HOI C0039231 (Tachycardia)
Pindolol pharmacokinetics in relation to time course of inhibition of exercise tachycardia.
Drug-HOI body from MEDLINE PMID 427002 using UMLS drug C0031937 (Pindolol) and UMLS HOI C0039231 (Tachycardia)
Oncotic effects of dilutional bypass, albumin, and diuretics.
Drug-HOI body from MEDLINE PMID 4714433 using UMLS drug C0012798 (Diuretics) and UMLS HOI C0013604 (Edema)
Pacing induction of ventricular tachycardia was performed prior to and following intravenous or oral administration of procainamide (eight patients), disopyramide phosphate (nine patients), aprindine (five patients) and propranolol (four patients).
ged from 2 to 12 (mean 5 +/- 4) attacks per year.
Successful drug response (prevention of ventricul
Drug-HOI body from MEDLINE PMID 7357967 using UMLS drug C0700534 (Disopyramide Phosphate) and UMLS HOI C0042514 (Tachycardia, Ventricular)
Cimetidine may have been responsible for the observed complications due to its effect on serum parathyroid hormone level.
sions until the cimetidine treatment was stopped.
Drug-HOI body from MEDLINE PMID 7259516 using UMLS drug C0008783 (Cimetidine) and UMLS HOI C0009566 (Complication)
Ureteral reflux in female patients who also have latent uninhibited neurogenic bladder occurs synchronously with uninhibited contraction, is blocked by buscopan and is aggravated by besacholine.
Intrinsic neuromuscular antireflux mechanism of t
Drug-HOI body from MEDLINE PMID 608818 using UMLS drug C0701019 (Buscopan) and UMLS HOI C1140999 (Contraction)
She developed analgesic nephropathy due to phenacetin, and constrictive pericarditis, probably due to methysergide treatment.
ld woman who suffered from migraine is described.
Drug-HOI body from MEDLINE PMID 982213 using UMLS drug C0031364 (Phenacetin) and UMLS HOI C0149938 (Analgesic nephropathy)
The effect of ajmaline in atrial flutter.
Drug-HOI body from MEDLINE PMID 302078 using UMLS drug C0001888 (Ajmaline) and UMLS HOI C0004239 (Atrial Flutter)
Conjunctiva proximal to the ulcer produced definite zones of lysis, whereas control specimens taken remote to the ulceration produced no lysis.
of diffuse zones in the gel surrounding the well.
This direct evidence for collagenase involvement
Drug-HOI body from MEDLINE PMID 220878 using UMLS drug C1564799 (Zonal) and UMLS HOI C0024348 (Lysis)
In the light of the present and earlier studies tolfenamic acid appears to cause less side-effects than oxyphenbutazone in prolonged treatment.
nt in the drug-treated than in the placebo group.
Drug-HOI body from MEDLINE PMID 1101903 using UMLS drug C0076799 (tolfenamic acid) and UMLS HOI C0879626 (Adverse effects)
Apparent resistance to hypotensive effect of clonidine.
Drug-HOI body from MEDLINE PMID 832037 using UMLS drug C0009014 (Clonidine) and UMLS HOI C0857353 (Hypotensive)
Inhibition of allergic reactions by cromoglycate and by AH 7079 in patients with allergic airway disease.
Drug-HOI body from MEDLINE PMID 4201413 using UMLS drug C0010347 (Cromoglycate) and UMLS HOI C1527304 (Allergic Reaction)
The relation of body weight to side effects associated with oral contraceptives.
Drug-HOI body from MEDLINE PMID 326339 using UMLS drug C0009905 (Contraceptives, Oral) and UMLS HOI C0879626 (Adverse effects)
Letter: Cardiac arrhythmia induced by phenothiazine.
Drug-HOI body from MEDLINE PMID 53484 using UMLS drug C0031434 (phenothiazine) and UMLS HOI C0003811 (cardiac arrhythmia)
[Evaluation of effect of pyridinolcarbamate on cerebrovascular diseases under controlled trial].
Drug-HOI body from MEDLINE PMID 4895667 using UMLS drug C0034257 (Pyridinolcarbamate) and UMLS HOI C0007820 (Cerebrovascular Disorders)
This is taken as confirmation of the potential of chlormethiazole to produce physiological dependence.
ucinations and muscular spasm and coarse jerking.
Some personal opinions of the author regarding in
Drug-HOI body from MEDLINE PMID 1260235 using UMLS drug C0008221 (Chlormethiazole) and UMLS HOI C0439857 (Dependence)
Reduction by naproxen of excessive menstrual bleeding in women using intrauterine devices.
Drug-HOI body from MEDLINE PMID 7005780 using UMLS drug C0027396 (Naproxen) and UMLS HOI C0025323 (Menorrhagia)
Both drugs induce a respiratory depression (decrease in tidal volume and minute ventilation with acceleration of the respiratory frequency) with slight respiratory acidosis, but lorazepam causes no significant hypoxemia and has a shorter duration of action than diazepam.
0 patients with chronic obstructive lung disease.
Nevertheless, if tranquillisers are indicated in
Drug-HOI body from MEDLINE PMID 4156289 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0235063 (Respiratory Depression)
[Allergic reactions caused by mepivacaine (author's transl)].
Drug-HOI body from MEDLINE PMID 633623 using UMLS drug C0025384 (Mepivacaine) and UMLS HOI C1527304 (Allergic Reaction)
Letter: Jaundice associated with naproxen.
Drug-HOI body from MEDLINE PMID 4133693 using UMLS drug C0027396 (Naproxen) and UMLS HOI C0022346 (Icterus)
In conclusion, the C osteotomy, the sagittal split osteotomy, genioplasty, and additional procedures--such as a mandibular alveolar osteotomy to intrude supraerupted teeth--when indicated, can provide very favorable results in cases of retrognathia or micrognathia of the mandible.
a part of the armamentarium of the oral surgeon.
Drug-HOI body from MEDLINE PMID 1061034 using UMLS drug C0309049 (FAVOR) and UMLS HOI C0035353 (Retrognathism)
Drug-HOI body from MEDLINE PMID 1061034 using UMLS drug C0309049 (FAVOR) and UMLS HOI C0025990 (Micrognathism)
Liver failure associated with halothane.
Drug-HOI body from MEDLINE PMID 593045 using UMLS drug C0018549 (Halothane) and UMLS HOI C0085605 (Liver Failure)
Salbutamol caused a relative tachycardia.
were equally effective during the first 24 hours.
Hydrocortisone was given after 2 hours, but did n
Drug-HOI body from MEDLINE PMID 383024 using UMLS drug C0001927 (Albuterol) and UMLS HOI C0039231 (Tachycardia)
Korinfar had a pronounced growth hypotensive effect and induced tachycardia, which is an increased dose hindered growth of exercise tolerance.
output by 70--80% and 200 mg of isoptin--by 136%.
The negative chronotropic effect of isoptin incre
Drug-HOI body from MEDLINE PMID 7259869 using UMLS drug C0700866 (Corinfar) and UMLS HOI C0857353 (Hypotensive)
[Hypotensive effect of intravenous propanidid. 1. Effect of preadministration of antihistaminics and glucocorticoids].
Drug-HOI body from MEDLINE PMID 4587955 using UMLS drug C0003360 (Antihistamines) and UMLS HOI C0857353 (Hypotensive)
Side effects attributable to labetalol were few.
ear to contribute to blood pressure reduction. 3.
The effective dose ratio labetalol: propranolol w
Drug-HOI body from MEDLINE PMID 367410 using UMLS drug C0022860 (Labetalol) and UMLS HOI C0879626 (Adverse effects)
The infusion rate of isoproterenol required to produce tachycardia was increased sevenfold by 800 mg/day labetalol and tenfold by 1600 mg/day.
response to exercise were significantly blunted.
More than twice the control dose of phenylephrine
Drug-HOI body from MEDLINE PMID 12880 using UMLS drug C0022245 (Isoproterenol) and UMLS HOI C0039231 (Tachycardia)
Thus, physicians should be aware of the possibility that timed-release aspirin causes small intestinal hemorrhage in such patients.
ions in association with the presence of aspirin.
Drug-HOI body from MEDLINE PMID 314279 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0520561 (Small intestinal hemorrhage)
Hypotensive effect of fenfluramine in the treatment of obesity.
Drug-HOI body from MEDLINE PMID 5557039 using UMLS drug C0015827 (Fenfluramine) and UMLS HOI C0857353 (Hypotensive)
Abdominal distention and aortic obstruction associated with phenothiazines.
Drug-HOI body from MEDLINE PMID 6892531 using UMLS drug C0031436 (Phenothiazines) and UMLS HOI C0596118 (Aortic occlusion)
Toxic psychosis due to cyproheptadine in a child on hemodialysis: a case report.
Drug-HOI body from MEDLINE PMID 264413 using UMLS drug C0010620 (Cyproheptadine) and UMLS HOI C0033941 (Psychoses, Substance-Induced)
Effect of histamine H2-receptor antagonists on delayed hypersensitivity.
Drug-HOI body from MEDLINE PMID 76165 using UMLS drug C0019593 (Histamine H2 Antagonists) and UMLS HOI C0020522 (Delayed Hypersensitivity)
currently available antiparkinsonian medications.
Therefore, it may be particulary useful in patien
Drug-HOI body from MEDLINE PMID 239908 using UMLS drug C0002403 (Amantadine) and UMLS HOI C0879626 (Adverse effects)
The degree of pressure rise was similar with both drugs but propranolol suppressed isometric exercise-induced tachycardia.
ed the pressor response to isometric exercise. 8.
Drug-HOI body from MEDLINE PMID 41550 using UMLS drug C0033497 (Propranolol) and UMLS HOI C0039231 (Tachycardia)
Phencyclidine hydrochloride (PCP) is a psychoactive drug that in small doses produces agitation, excitement, and disorientation, but in larger doses results in stupor, convulsions, coma, and death.
Two accident victims under the effects of phencyc
Drug-HOI body from MEDLINE PMID 7373800 using UMLS drug C0033978 (Psychotropic Drugs) and UMLS HOI C0233407 (Disorientation)
Drug-HOI body from MEDLINE PMID 7373800 using UMLS drug C0282301 (Phencyclidine Hydrochloride) and UMLS HOI C0233407 (Disorientation)
During the double-blind study no difference could be shown between clomipramine and placebo in their effect on premature ejaculation.
patients entered the trial, sixteen completed it.
But during the follow-up period nine patients wer
Drug-HOI body from MEDLINE PMID 7193614 using UMLS drug C0009010 (Clomipramine) and UMLS HOI C0033038 (Premature Ejaculation)
Drug-HOI body from MEDLINE PMID 7462710 using UMLS drug C0031436 (Phenothiazines) and UMLS HOI C0220982 (Ketoacidosis)
Independent lesions of fixed eruption due to two unrelated drugs in the same patient.
Drug-HOI body from MEDLINE PMID 159715 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0151629 (Fixed eruption)
Studies have suggested that the hypotensive effect of pilocarpine may be influenced by the vehicle;
al problems in management of open-angle glaucoma.
therefore, 13 relatively resistant black patients
Drug-HOI body from MEDLINE PMID 921144 using UMLS drug C0031923 (Pilocarpine) and UMLS HOI C0857353 (Hypotensive)
The intravenous administration of 5 and 10 mg of diazepam caused anterograde amnesia in 50 and 90% of adults, the peak effect occurring in 2-3 min and action persisting for 20-30 minutes.2.
Hyoscine (0.4 and 0.6 mg) caused amnesia in 35 an
Drug-HOI body from MEDLINE PMID 5015033 using UMLS drug C0012010 (Diazepam) and UMLS HOI C0233795 (Amnesia, Anterograde)
The effect of propranolol, prindolol, practolol and verapamil versus placebo on exercise induced tachycardia in patients with ventricular preexcitation.
Drug-HOI body from MEDLINE PMID 1002350 using UMLS drug C0042523 (Verapamil) and UMLS HOI C0039231 (Tachycardia)
The close time relationship and indirect evidence strongly suggest that chlormethiazole had an important role in the fatal outcome of the patients, but definite proof of this way was not possible to obtain.
ction with chlormethiazole (Heminevrin) infusion.
Present or past alcohol abuse and respiratory, li
Drug-HOI body from MEDLINE PMID 1002357 using UMLS drug C0008221 (Chlormethiazole) and UMLS HOI C0206277 (Fatal Outcome)
[Jaundice caused by oral contraceptives].
Drug-HOI body from MEDLINE PMID 1018539 using UMLS drug C0009905 (Contraceptives, Oral) and UMLS HOI C0022346 (Icterus)
Effects of Tybamate in chronic schizophrenia.
Drug-HOI body from MEDLINE PMID 5094163 using UMLS drug C0175163 (tybamate) and UMLS HOI C0221765 (Chronic schizophrenia)
Apart from any direct cytotoxic effect of alcohol the metabolic acidosis and hypoglycaemia associated with acute alcoholic poisoning may be important factors in the pathogenesis of the morphological changes.
lood leucocytes associated with acute alcoholism.
Drug-HOI body from MEDLINE PMID 7451665 using UMLS drug C0001962 (Ethanol) and UMLS HOI C0699748 (Pathogenesis)
Overdrive pacing, in combination with propranolol, successfully suppressed the arrhythmias, and the patient remains well after 15 months of follow-up.
, procainamide and propranolol) was unsuccessful.
Drug-HOI body from MEDLINE PMID 1246958 using UMLS drug C0033497 (Propranolol) and UMLS HOI C0003811 (cardiac arrhythmia)
Drug-HOI body from MEDLINE PMID 5120169 using UMLS drug C0017845 (Glutethimide) and UMLS HOI C0151629 (Fixed eruption)
Drug-HOI body from MEDLINE PMID 40144 using UMLS drug C0017592 (Glafenine) and UMLS HOI C0151763 (Liver damage)
The end point is the day on which the patient feels the drug is either ineffective or produces intolerable side effects.
ged to vary the dose to suit their own symptoms.)
Each cohort comprises 100 patients and the result
Drug-HOI body from MEDLINE PMID 6787855 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0879626 (Adverse effects)
Naproxen-aspirin combination in suppression of the inflammatory response to an empyema.
Drug-HOI body from MEDLINE PMID 7242413 using UMLS drug C0004057 (Aspirin) and UMLS HOI C1155266 (Inflammatory Response)
The review of the cases treated with immunosuppressive drugs proves that this treatment is effective and emphasizes the probable autoimmune pathogenesis of PRCA.
ent remission when treated with Cyclophosphamide.
Drug-HOI body from MEDLINE PMID 683588 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0443146 (Autoimmune)
As sulpiride has both healing effects on the ulcer and an analgesic effect against pain it can be prescribed in association with antacid mixtures for the treatment of duodenal ulcers.
s highest in the sulpiride group (84,6 per cent).
Drug-HOI body from MEDLINE PMID 219500 using UMLS drug C0038803 (Sulpiride) and UMLS HOI C0041582 (Ulcer)
Alcohol, hepatotoxic drugs, toxins, viral and chronic active hepatitis, hemolysis, and extrahepatic biliary obstruction were eliminated as causes of the jaundice.
es or extrahepatic biliary obstruction was found.
We believe that the intermittent intrahepatic cho
Drug-HOI body from MEDLINE PMID 921451 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0022346 (Icterus)
Drug-HOI body from MEDLINE PMID 921451 using UMLS drug C0001962 (Ethanol) and UMLS HOI C0022346 (Icterus)
Effect of naloxone on hyperphagia in Prader-Willi syndrome.
Drug-HOI body from MEDLINE PMID 6103230 using UMLS drug C0027358 (Naloxone) and UMLS HOI C0020505 (Hyperphagia)
New propionic acid derivatives are claimed to induce a lower incidence of gastrointestinal bleeding and hemostatic disturbance than older anti-inflammatory analgesics such as aspirin.
One of these (ibuprofen, Motrin) was given (600 m
Drug-HOI body from MEDLINE PMID 699486 using UMLS drug C0072186 (Propionic acid) and UMLS HOI C0017181 (Gastrointestinal Hemorrhage)
Bupicomide significantly reduced systolic, diastolic, and mean arterial pressure and peripheral vascular resistance and this hypotensive effect was associated with a reflexive increase in heart rate, left ventricular ejection rate, and cardiac index;
ated essential hypertension of moderate severity.
it had no effect upon other reflexive sympathetic
Drug-HOI body from MEDLINE PMID 782220 using UMLS drug C0054225 (bupicomide) and UMLS HOI C0857353 (Hypotensive)
Its use in combination with antirheumatic agents did not cause any complications and made it possible to reduce the activity of the process in most cases with grade I and after repeated courses also in grade II activity of rheumatism.
olysin 0) and Coxsackie A13, A18, and B3 viruses.
Treatment with titrated gamma-globulin stimulates
Drug-HOI body from MEDLINE PMID 88541 using UMLS drug C0003191 (Antirheumatic Agents) and UMLS HOI C0009566 (Complication)
Drug-HOI body from MEDLINE PMID 7242573 using UMLS drug C0591099 (Anturane) and UMLS HOI C0151746 (Abnormal renal function)
[Letter: Pleuropulmonary fibrosis due to methysergide with circulating immune complexes[].
Drug-HOI body from MEDLINE PMID 1196890 using UMLS drug C0025842 (Methysergide) and UMLS HOI C0016059 (Fibrosis)
Diflunisal produced significantly high incidence of gastro-intestinal upsets, leading to the withdrawal of 2 patients at Week 4.
ly as good as or better than previous medication.
Drug-HOI body from MEDLINE PMID 359251 using UMLS drug C0012228 (Diflunisal) and UMLS HOI C0700361 (Emotional distress)
Unlike propranolol, practolol did not produce any adverse effects on bronchial smooth muscle.
but did not affect the degree of S-T depression.
Hence it is concluded that practolol is an effect
Drug-HOI body from MEDLINE PMID 4392983 using UMLS drug C0032896 (Practolol) and UMLS HOI C0879626 (Adverse effects)
It can thus be concluded that fominoben by improving the ventilation-perfusion ratio leads to an enlargement of the active diffusion surface (capillary surface), from which the increase in the global diffusion capacity results.
sulting respiratory insufficiency, are increased.
The site of action of fominoben for its positive
Drug-HOI body from MEDLINE PMID 156031 using UMLS drug C0650235 (fominoben) and UMLS HOI C0020564 (Hypertrophy)
Psychomotor impairment due to THC was not significantly altered by the simultaneous administration of CBD, but a trend indicating a decrease in THC-like effects was observed after the combination.
cantly attenuated the subjective euphoria of THC.
When administered alone CBD was inactive for all
Drug-HOI body from MEDLINE PMID 770048 using UMLS drug C0039663 (Tetrahydrocannabinol) and UMLS HOI C0679465 (Psychomotor Impairment)
Halofenate had a marked hypouricemic effect that was greater than that of clofibrate.
re increased by clofibrate but not by halofenate.
The hypouricemic effect of halofenate and clofibr
Drug-HOI body from MEDLINE PMID 177242 using UMLS drug C0018541 (Halofenate) and UMLS HOI C0221333 (Hypouricemia)
The hypouricemic effect of halofenate and clofibrate was paralleled by a concomitant decrease in serum bilirubin.
effect that was greater than that of clofibrate.
Abnormal increases in serum creatine phosphokinas
Drug-HOI body from MEDLINE PMID 177242 using UMLS drug C0009002 (Clofibrate) and UMLS HOI C0221333 (Hypouricemia)
3 The two beta-adrenoceptor blockers were compared using doses earlier shown to have the same beta-adrenoceptor blocking potency, as measured by their effect on exercise tachycardia in healthy men.
from the study due to side effects on both drugs.
4 Arterial blood pressure was reduced to the same
Drug-HOI body from MEDLINE PMID 375959 using UMLS drug C0001645 (Adrenergic beta-Antagonists) and UMLS HOI C0039231 (Tachycardia)
Since the malformations noted in her four offspring are more extensive and severe in each subsequent child, the question arises as to the possible cumulative effect of antiepileptic drugs in producing congenital malformations.
ar history of continuous medication for seizures.
The observations in this family strongly support
Drug-HOI body from MEDLINE PMID 821338 using UMLS drug C0003299 (Antiepileptic Agents) and UMLS HOI C0000768 (Congenital Abnormality)
Effect of topical papaverine in preventing thrombosis following arteriotomies.
Drug-HOI body from MEDLINE PMID 4561479 using UMLS drug C0030350 (Papaverine) and UMLS HOI C0040053 (Thrombosis)
A case report of cimetidine-induce depressive syndrome.
Drug-HOI body from MEDLINE PMID 7435686 using UMLS drug C0008783 (Cimetidine) and UMLS HOI C0086133 (Depressive Syndrome)
Gilles de la Tourette's disorder associated with pemoline.
Drug-HOI body from MEDLINE PMID 6933864 using UMLS drug C0030800 (Pemoline) and UMLS HOI C0040517 (Gilles de la Tourette syndrome)
These data suggested that the hypersensitivity reaction caused by allopurinol had immune complex deposition as the central feature in pathogenesis.
f allopurinol, allopurinol metabolites and serum.
The predominance of IgM may provide a distinctive
Drug-HOI body from MEDLINE PMID 952299 using UMLS drug C0002144 (Allopurinol) and UMLS HOI C0020517 (Hypersensitivity)
[Cerebral vascular occlusion and nodular hyperplasia of the liver caused by contraceptives].
Drug-HOI body from MEDLINE PMID 7374605 using UMLS drug C0009871 (Contraceptive Agents) and UMLS HOI C0020510 (Nodular hyperplasia)
The thrombosis of the basilar artery and the focal nodular hyperplasia are considered to be induced by contraceptives.
who had taken oral contraceptives for ten years.
Drug-HOI body from MEDLINE PMID 7374605 using UMLS drug C0009871 (Contraceptive Agents) and UMLS HOI C0040053 (Thrombosis)
Complete clearing occurred with prednisone therapy, but readministration of furosemide resulted in bulla formation.
ions. Furosemide (Lasix) was suspected primarily.
Drug-HOI body from MEDLINE PMID 1108805 using UMLS drug C0016860 (Furosemide) and UMLS HOI C0005758 (Bulla)
Quinidine sulfate used prophylactically because of its negative dromotropic effect on the accessory pathway promotes A-V transmission via the A-V node.
e, at times, ventricular fibrillation may result.
Drug-HOI body from MEDLINE PMID 583897 using UMLS drug C0034415 (Quinidine Sulfate) and UMLS HOI C0264897 (Accelerated atrioventricular conduction)
[A case of mesenteric infarct due to Lyndiol].
Drug-HOI body from MEDLINE PMID 5559522 using UMLS drug C0950179 (Lyndiol) and UMLS HOI C0021308 (Infarction)
The authors, by describing their own observations made on eight patients showing extrapyramidal syndromes as side effects of metoclopramide (Cerucal) medication, report the various kinds of possible side effects, discussing their conformity with side effects produced by conventional neuroleptics and showing methods of treatment.
Metoclopramide is known to produce three froms of
Drug-HOI body from MEDLINE PMID 1019273 using UMLS drug C0040615 (Antipsychotic Agents) and UMLS HOI C0879626 (Adverse effects)
Therapy is in the following form regardless of the particular side effect produced by the said drug: 1.
drome; 2. acathisia; and 3. Parkinson's syndrome.
Administration of antiparkinsonian remedies; 2. a
Drug-HOI body from MEDLINE PMID 1019273 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0879626 (Adverse effects)
Drug-HOI body from MEDLINE PMID 4214979 using UMLS drug C0039052 (Sympathomimetics) and UMLS HOI C0033975 (Psychotic Disorders)
Drug-HOI body from MEDLINE PMID 4214979 using UMLS drug C0010347 (Cromoglycate) and UMLS HOI C0033975 (Psychotic Disorders)
Drug-HOI body from MEDLINE PMID 4652957 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0002792 (Anaphylaxis)
These data confirm the potent vasodilatory effects of NP and GTN and suggest that NP has a relatively balanced effect on the arterial and venous circulation, and GTN seems to produce more potent venodilatation than arterial dilatation.
These observations provide a basis for a more rat
Drug-HOI body from MEDLINE PMID 810265 using UMLS drug C0731141 (GTN) and UMLS HOI C0595862 (Vasodilation disorder)
[Hemodynamic effects of dopamine, dobutamine and isoproterenol in chronic respiratory insufficiency].
Drug-HOI body from MEDLINE PMID 35062 using UMLS drug C0022245 (Isoproterenol) and UMLS HOI C0035229 (Respiratory Insufficiency)
Drug-HOI body from MEDLINE PMID 35062 using UMLS drug C0012963 (Dobutamine) and UMLS HOI C0035229 (Respiratory Insufficiency)
Drug-HOI body from MEDLINE PMID 35062 using UMLS drug C0013030 (Dopamine) and UMLS HOI C0035229 (Respiratory Insufficiency)
The magnitude and duration of effect of a single 40-mg oral tablet of oxprenolol on the tachycardias associated with motor-car driving, isoprenaline infusion, and walking were compared against placebo in six normal people by a double-blind study.
The tachycardias due to driving and isoprenaline
Drug-HOI body from MEDLINE PMID 4753236 using UMLS drug C0022245 (Isoproterenol) and UMLS HOI C0039231 (Tachycardia)
Although no cardiac monitoring was available, a continuous lidocaine infusion was used during recompression treatment to treat the PVCs, and it appeared to produce no untoward side effects.
ture ventricular contractions (PVC) is presented.
The concerns about using lidocaine in the dysbari
Drug-HOI body from MEDLINE PMID 7436069 using UMLS drug C0023660 (Lidocaine) and UMLS HOI C0879626 (Adverse effects)
The reduction in exercise tachycardia produced by 80 mg alinidine was similar to that after 40 mg propranolol, but alinidine had no effect on an isoprenaline tachycardia.
al pressure in the standing and supine positions.
These observations indicate that alinidine reduce
Drug-HOI body from MEDLINE PMID 6109990 using UMLS drug C0102151 (alinidine) and UMLS HOI C0039231 (Tachycardia)
Fatal pulmonary hemorrhage due to nitrofurantoin.
Drug-HOI body from MEDLINE PMID 6986130 using UMLS drug C0028156 (Nitrofurantoin) and UMLS HOI C0151701 ([D]Pulmonary hemorrhage)
Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities.
These anomalies were found in various degrees of
Drug-HOI body from MEDLINE PMID 717308 using UMLS drug C0031507 (Phenytoin) and UMLS HOI C0000768 (Congenital Abnormality)
A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes.
Drug-HOI body from MEDLINE PMID 4926376 using UMLS drug C0020616 (Hypoglycemic Agents) and UMLS HOI C0009566 (Complication)
Electroencephalographic effects of adrenochrome semicarbazone in schizophrenia: quantitative amplitude analysis.
Drug-HOI body from MEDLINE PMID 4944698 using UMLS drug C0006972 (carbazochrome) and UMLS HOI C0036341 (Schizophrenia)
the rate of the decline of the hypotensive effect of clonidine varied widely between patients and was not related to baseline blood pressure.
urves or the reduction in mean arterial pressure;
Drug-HOI body from MEDLINE PMID 776490 using UMLS drug C0009014 (Clonidine) and UMLS HOI C0857353 (Hypotensive)
The drug was given three times daily and caused no side effects.
e improved to a statistically significant degree.
Drug-HOI body from MEDLINE PMID 336078 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0879626 (Adverse effects)
Effect of atropine on the tachycardia of hyperthyroidism.
Drug-HOI body from MEDLINE PMID 4552897 using UMLS drug C0004259 (Atropine) and UMLS HOI C0039231 (Tachycardia)
[Liver damage caused by nitrofurantoin].
Drug-HOI body from MEDLINE PMID 7464962 using UMLS drug C0028156 (Nitrofurantoin) and UMLS HOI C0151763 (Liver damage)
The effect of lithium treatment on manic symptoms and levels of monoamine metabolites in cerebrospinal fluid of manic depressive patients.
Drug-HOI body from MEDLINE PMID 1105629 using UMLS drug C0599682 (monoamine) and UMLS HOI C0746402 (MANIC SYMPTOM)
Pretreatment with diazepam did not alter significantly the dose of strophanthidin K required to induce ventricular tachycardia in the dog.
ventricular tachycardia threshold significantly.
The value of diazepam as a cardiac anti-arrhythmi
Drug-HOI body from MEDLINE PMID 5212357 using UMLS drug C0012010 (Diazepam) and UMLS HOI C0042514 (Tachycardia, Ventricular)
Cardiac arrest and alopecia induced by beta-blocker.
Drug-HOI body from MEDLINE PMID 6110689 using UMLS drug C0001645 (Adrenergic beta-Antagonists) and UMLS HOI C0002170 (Alopecia)
Drug-HOI body from MEDLINE PMID 6110689 using UMLS drug C0001645 (Adrenergic beta-Antagonists) and UMLS HOI C0018790 (Heart Arrest)
An unusual dual hypersensitivity reaction induced by diphenylhydantoin.
Drug-HOI body from MEDLINE PMID 4267436 using UMLS drug C0031507 (Phenytoin) and UMLS HOI C0020517 (Hypersensitivity)
Continued investigations into the effect of diuretics upon oedema of the hand following operation for Dupuytren's contracture: Bumetanide Leo.
Drug-HOI body from MEDLINE PMID 4589102 using UMLS drug C0012798 (Diuretics) and UMLS HOI C0013604 (Edema)
Drug-HOI body from MEDLINE PMID 4941698 using UMLS drug C0020616 (Hypoglycemic Agents) and UMLS HOI C0009566 (Complication)
[Diabetogenic effects of ritodrine. Severe hyperglycemia and ketoacidosis in 5 pregnant diabetics and 1 nondiabetic during treatment with ritodrine or ritodrine combined with betamethasone].
Drug-HOI body from MEDLINE PMID 416533 using UMLS drug C0035661 (Ritodrine) and UMLS HOI C0220982 (Ketoacidosis)
The successful therapy of lipoatrophy with monocomponent insulin in all cases hitherto published confirms the hypothesis that a local antigen-antibody-reaction to highly molecular constituents of the commercial mixed insulins causes the atrophy of fatty tissue.
e pig led to the restoration of the fatty tissue.
Drug-HOI body from MEDLINE PMID 1035452 using UMLS drug C1579433 (Insulins) and UMLS HOI C0333641 (Atrophic)
Role of doxapram in reducing pulmonary complications after major surgery.
Drug-HOI body from MEDLINE PMID 764914 using UMLS drug C0013084 (Doxapram) and UMLS HOI C0281169 (pulmonary complications)
[Jaundice caused by niflumic acid (Inflaryl)].
Drug-HOI body from MEDLINE PMID 4849020 using UMLS drug C0028067 (Niflumic Acid) and UMLS HOI C0022346 (Icterus)
[Clinical effect of nitrazepam on psychoneurosis with insomnia].
Drug-HOI body from MEDLINE PMID 4900118 using UMLS drug C0028126 (Nitrazepam) and UMLS HOI C0027932 (Neurotic Disorders)
[Postoperative fever, jaundice and cognition disorder: acute hepatic necrosis caused by halothane].
Drug-HOI body from MEDLINE PMID 1240439 using UMLS drug C0018549 (Halothane) and UMLS HOI C0001364 (Massive Hepatic Necrosis)
Cardiac arrhythmias caused by chloral hydrate.
Drug-HOI body from MEDLINE PMID 922401 using UMLS drug C0008161 (Chloral Hydrate) and UMLS HOI C0003811 (cardiac arrhythmia)
Although mefenamic acid has many of the pharmacologic and physicochemical properties of aspirin and produces gastrointestinal ulceration in animals when administered in large doses, the English literature reveals only one case of gastric ulceration and a single instance of upper-gastrointestinal tract hemorrhage associated with its use.
eding ulcer in the third portion of the duodenum.
This case warns that mefenamic acid may cause ser
Drug-HOI body from MEDLINE PMID 949194 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0041582 (Ulcer)
The effects of chlordiazepoxide on self-rated depression, anxiety, and well-being.
Drug-HOI body from MEDLINE PMID 115039 using UMLS drug C0008188 (Chlordiazepoxide) and UMLS HOI C0011581 (Depressive disorder)
The effect of a selective beta adrenergic blocking agent on ventricular arrhythmias in the first year following myocardial infarction.
Drug-HOI body from MEDLINE PMID 6996660 using UMLS drug C0001645 (Adrenergic beta-Antagonists) and UMLS HOI C0085612 (Ventricular arrhythmia)
Anatomic dissection or serial sections of blocks of the valve zone demonstrated that either a single or a double flap caused obstruction.
lve obstructed antegrade but not retrograde flow.
The valve was coapted against the opposite wall o
Drug-HOI body from MEDLINE PMID 7420567 using UMLS drug C1564799 (Zonal) and UMLS HOI C0028778 (Obstruction)
Cardiogenic shock associated with disopyramide phosphate.
Drug-HOI body from MEDLINE PMID 7359659 using UMLS drug C0700534 (Disopyramide Phosphate) and UMLS HOI C0036980 (Shock, Cardiogenic)
Compared to the placebo period (190/117 mm Hg) the hypotensive effect of atenolol (-24/16 mm Hg) was more pronounced than the hypotensive effect of bendrofluazide (-17/6 mm Hg).
ly) and the beta blocker atenolol (600 mg daily).
Arguments in favor of initiating antihypertensive
Drug-HOI body from MEDLINE PMID 14468 using UMLS drug C0004147 (Atenolol) and UMLS HOI C0857353 (Hypotensive)
Drug-HOI body from MEDLINE PMID 14468 using UMLS drug C0004975 (Bendroflumethiazide) and UMLS HOI C0857353 (Hypotensive)
Arguments in favor of initiating antihypertensive drug therapy with beta blocker were its more powerful hypotensive effect, the quicker onset of its action, less metabolic disturbance, decreased frequency of complaints and patient's preference.
potensive effect of bendrofluazide (-17/6 mm Hg).
On thiazides body weight and the frequency of swo
Drug-HOI body from MEDLINE PMID 14468 using UMLS drug C0001645 (Adrenergic beta-Antagonists) and UMLS HOI C0857353 (Hypotensive)
Letter: Hypotension after angiotensin-II infusion and hypovolaemia induced by diuretic.
Drug-HOI body from MEDLINE PMID 4134328 using UMLS drug C0012798 (Diuretics) and UMLS HOI C0546884 (Hypovolemia)
Drug-HOI body from MEDLINE PMID 7359747 using UMLS drug C0038792 (Sulindac) and UMLS HOI C0011206 (Delirium)
The effect of clomipramine hydrochloride in severe obsessive-compulsive disorder (OCD) was compared with that of nortriptyline hydrochloride and placebo in a five-week randomized, double-blind trial.
Clomipramine, but not nortriptyline, was superior
Drug-HOI body from MEDLINE PMID 7436690 using UMLS drug C0282107 (Clomipramine Hydrochloride) and UMLS HOI C0028768 (Obsessive-Compulsive Disorder)
A combined tablet of atenolol and bendrofluazide taken once daily would be a simple regimen to follow and would provide almost as much hypotensive effect as a twice-daily regimen incorporating a modest dose of hydrallazine.
at least 24 hours after the last dose of tablets.
The hypotensive effect of atenolol was equal to t
Drug-HOI body from MEDLINE PMID 329948 using UMLS drug C0004975 (Bendroflumethiazide) and UMLS HOI C0857353 (Hypotensive)
Drug-HOI body from MEDLINE PMID 329948 using UMLS drug C0004147 (Atenolol) and UMLS HOI C0857353 (Hypotensive)
A double-blind comparison of fluphenazine decanoate and flupenthixol decanoate in 40 consecutive admissions showed no difference in anti-psychotic effect or extrapyramidal side effects after 56 days.
However, the trial identified a different effect
Drug-HOI body from MEDLINE PMID 1096536 using UMLS drug C0060578 (flupenthixol decanoate) and UMLS HOI C0033975 (Psychotic Disorders)
Drug-HOI body from MEDLINE PMID 1096536 using UMLS drug C0060580 (fluphenazine depot) and UMLS HOI C0033975 (Psychotic Disorders)
Does piracetam counteract the ECT-induced memory dysfunctions in depressed patients?
Drug-HOI body from MEDLINE PMID 1096538 using UMLS drug C0031977 (Piracetam) and UMLS HOI C0233794 (Memory impairment)
Previous reports of benign gastric ulceration in patients with achlorhydria are reviewed, and the potential role of aspirin in the pathogenesis of benign ulceration in the absence of acid is discussed.
cious anemia in association with aspirin therapy.
Drug-HOI body from MEDLINE PMID 7353461 using UMLS drug C0004057 (Aspirin) and UMLS HOI C0699748 (Pathogenesis)
It is concluded that minoxidil, producing a hypotensive effect of slow onset, may find a place as a therapeutic addition to symptomatic patients with severe and therapy-resistant hypertensive cardiovascular disease, provided adequate measures are taken to counteract side-effects, especially water retention and development of oedemas.
idil had to be withdrawn because of side-effects.
Drug-HOI body from MEDLINE PMID 238365 using UMLS drug C0026196 (Minoxidil) and UMLS HOI C0857353 (Hypotensive)
The effect of naproxen-sodium on the intrauterine pressure and menstrual pain of dysmenorrheic patients.
Drug-HOI body from MEDLINE PMID 320630 using UMLS drug C0546873 (Naproxen sodium) and UMLS HOI C0013390 (Dysmenorrhea)
[Effect of prazosin in therapy-resistant chronic cardiac failure (author's transl)].
Drug-HOI body from MEDLINE PMID 510213 using UMLS drug C0032912 (Prazosin) and UMLS HOI C0231178 (Chronic failure)
Neither drug caused tachycardia or arrhythmia.
ond (FEV1), and mean percentage increase in FEV1.
It was concluded that hexoprenaline aerosol was a
Drug-HOI body from MEDLINE PMID 349325 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0039231 (Tachycardia)
A review of the therapy that the patients were given incriminates anthralin, crude coal tar, ultraviolet light, and salicylic acid in the possible cause of the development of their bullous pemphigoid lesions.
had coexistent psoriasis and bullous pemphigoid.
Drug-HOI body from MEDLINE PMID 363061 using UMLS drug C0036079 (Salicylic Acid) and UMLS HOI C0005758 (Bulla)
Drug-HOI body from MEDLINE PMID 363061 using UMLS drug C0009137 (Coal Tar) and UMLS HOI C0005758 (Bulla)
Drug-HOI body from MEDLINE PMID 363061 using UMLS drug C0003166 (Anthralin) and UMLS HOI C0005758 (Bulla)
Drug-HOI body from MEDLINE PMID 1198218 using UMLS drug C0304497 (Cytotoxic agent) and UMLS HOI C0041582 (Ulcer)
Physiological saline is considered to be a more appropriate fluid for injection therapy than local anaesthetics since it is less likely to produce side-effects.
merely inserting a needle into the trigger point.
Drug-HOI body from MEDLINE PMID 6102230 using UMLS drug C0002934 (Local Anesthetics) and UMLS HOI C0879626 (Adverse effects)
The hypotensive effect of the drug is pronounced but mildly.
e volume of blood filling of the cranial vessels.
The oxygen tension in cerebral vessels depended m
Drug-HOI body from MEDLINE PMID 776659 using UMLS drug C0013227 (Pharmaceutical Preparations) and UMLS HOI C0857353 (Hypotensive)
The effect of topical povidone iodine on wound infection following abdominal surgery.
Drug-HOI body from MEDLINE PMID 7013895 using UMLS drug C0032857 (Povidone-Iodine) and UMLS HOI C0043241 (Wound Infection)
Allopurinol has several unique biochemical and metabolic properties that may increase its ability to cause hypersensitivity or toxic skin reactions.
ug, have been described in the recent literature.
Drug-HOI body from MEDLINE PMID 1232941 using UMLS drug C0002144 (Allopurinol) and UMLS HOI C0020517 (Hypersensitivity)
Muscle necrosis induced by intramuscular chlorpromazine.
Drug-HOI body from MEDLINE PMID 7360071 using UMLS drug C0008286 (Chlorpromazine) and UMLS HOI C0235957 (Muscle necrosis)