Becky Steck Christopher Park John F. O’Toole Matthias Kretzler Sean Mooney Anthony Huffman Asiyah Yu Lin Fred Dowd Hong Yu Jennifer Schaub Jie Zheng Long Tran Minh-Y Hoang Nguyen Qingliang Leon Li Suyuan Peng Yongqun "Oliver" He (YH) Yujia Tian OPMI is a biomedical ontology in the area of precision medicine and its related investigations. It is community-driven and developed by following the OBO Foundry ontology development principles. OWL-DL OPMI subject: Precision medicine and related investigations OPMI: Ontology of Precision Medicine and Investigation http://creativecommons.org/licenses/by/4.0/ 2026-06-20 BFO OWL specification label Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label BFO OWL specification label BFO CLIF specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label BFO CLIF specification label editor preferred label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label example example of usage A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> example of usage example of usage has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot OBI_0000281 has curation status has curation status definition definition textual definition A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software. The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> DEFINITION definition definition textual definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obfoundry.org/obo/obi> GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note 1 editor_note editor note editor note definition editor term editor Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition editor definition editor term editor term editor alternative term An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> alternative term alternative term definition source Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source definition source has obsolescence reason Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. PERSON:Alan Ruttenberg PERSON:Melanie Courtot has obsolescence reason curator note An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg IAO:0000232 uberon curator_notes 1 curator_notes curator note curator note curator notes term tracker item term tracker item the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ An IRI or similar locator for a request or discussion of an ontology term. An IRI or similar locator for a request or discussion of an ontology term. Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg The 'tracker item' can associate a tracker with a specific ontology term. The 'tracker item' can associate a tracker with a specific ontology term. term tracker item ontology term requester The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition. Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg The 'term requester' can credit the person, organization or project who request the ontology term. ontology term requester imported from For external terms/classes, the ontology from which the term was imported PERSON:Alan Ruttenberg PERSON:Melanie Courtot GROUP:OBI:<http://purl.obolibrary.org/obo/obi> imported from imported from expand expression to expand expression to expand assertion to OBO foundry unique label An alternative name for a class or property which is unique across the OBO Foundry. The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools . PERSON:Alan Ruttenberg PERSON:Bjoern Peters PERSON:Chris Mungall PERSON:Melanie Courtot GROUP:OBO Foundry <http://obofoundry.org/> OBO foundry unique label elucidation person:Alan Ruttenberg Person:Barry Smith Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms elucidation elucidation has associated axiom(nl) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom associated with a term expressed using natural language has associated axiom(nl) has associated axiom(nl) has associated axiom(fol) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom expressed in first order logic using CLIF syntax has associated axiom(fol) has associated axiom(fol) scheduled for obsoletion on or after Used when the class or object is scheduled for obsoletion/deprecation on or after a particular date. Chris Mungall, Jie Zheng https://github.com/geneontology/go-ontology/issues/15532 https://github.com/information-artifact-ontology/ontology-metadata/issues/32 GO ontology scheduled for obsoletion on or after C3829466 NCIT_C106180 term_mapping_to_UMLS term_mapping_to_NCIT An association that specifies one of three data types for a particular variable, String, Code or Number. A23 Conceptual Entity Has_PCDC_Data_Type Has_PCDC_Data_Type Has_PCDC_Data_Type An association that indicates a PCDC AML concept is an Authorized Value for a PCDC AML Variable concept. A24 Conceptual Entity Is_PCDC_AML_Authorized_Value_For_Variable Is_PCDC_AML_Authorized_Value_For_Variable Is_PCDC_AML_Authorized_Value_For_Variable An association that shows which PCDC AML Authorized Values are possible for a specific Variable. A26 Conceptual Entity Has_PCDC_AML_Authorized_Value Has_PCDC_AML_Authorized_Value Has_PCDC_AML_Authorized_Value An association connecting a CTDC Property concept to its dedicated value concept(s). A27 Conceptual Entity Has_CTDC_Value Has_CTDC_Value Has_CTDC_Value An association that indicates a PCDC EWS concept is an Authorized Value for a specific PCDC EWS Variable concept. A28 Conceptual Entity Is_PCDC_EWS_Authorized_Value_For_Variable Is_PCDC_EWS_Authorized_Value_For_Variable Is_PCDC_EWS_Authorized_Value_For_Variable An association that shows which Authorized Values are possible for a specific PCDC EWS Variable concept. A29 Conceptual Entity Has_PCDC_EWS_Authorized_Value Has_PCDC_EWS_Authorized_Value Has_PCDC_EWS_Authorized_Value An association that connects a concept representing a GDC property to its dedicated value concept(s). A31 Conceptual Entity Has_GDC_Value Has_GDC_Value Has_GDC_Value An association that that connects a concept representing a GDC value to any associated GDC property concept(s). A32 Conceptual Entity Is_Value_For_GDC_Property Is_Value_For_GDC_Property Is_Value_For_GDC_Property An association that indicates a concept is a dedicated Authorized Value concept for a specific PCDC GCT Variable. A33 Conceptual Entity Is_PCDC_GCT_Authorized_Value_For_Variable Is_PCDC_GCT_Authorized_Value_For_Variable Is_PCDC_GCT_Authorized_Value_For_Variable An association that shows which Authorized Values are possible for a specific PCDC GCT Variable. A34 Conceptual Entity Has_PCDC_GCT_Authorized_Value Has_PCDC_GCT_Authorized_Value Has_PCDC_GCT_Authorized_Value An association that indicates a PCDC ALL concept is a Authorized Value for an PCDC ALL Variable concept. A35 Conceptual Entity Is_PCDC_ALL_Authorized_Value_For_Variable Is_PCDC_ALL_Authorized_Value_For_Variable Is_PCDC_ALL_Authorized_Value_For_Variable An association that shows which PCDC ALL Authorized Values are possible for a specific Variable. A36 Conceptual Entity Has_PCDC_ALL_Authorized_Value Has_PCDC_ALL_Authorized_Value Has_PCDC_ALL_Authorized_Value An association that shows which Authorized Values are possible for a specific SeroNet Variable. A37 Conceptual Entity Has_SeroNet_Authorized_Value Has_SeroNet_Authorized_Value Has_SeroNet_Authorized_Value An association that shows which Authorized Values are possible for a specific PCDC OS Variable. A38 Conceptual Entity Has_PCDC_OS_Authorized_Value Has_PCDC_OS_Authorized_Value Has_PCDC_OS_Authorized_Value An association that shows which Authorized Values are possible for a specific PCDC HL Variable. A39 Conceptual Entity Has_PCDC_HL_Authorized_Value Has_PCDC_HL_Authorized_Value Has_PCDC_HL_Authorized_Value An association that shows which Authorized Values are possible for a specific DIPG/DMG Variable. A40 Conceptual Entity Has_DIPG_DMG_Authorized_Value Has_DIPG_DMG_Authorized_Value Has_DIPG_DMG_Authorized_Value An association specifying the Values for a specific OORO Prostate Cancer (PC) Attribute. A42 Conceptual Entity Has_OORO_PC_Value Has_OORO_PC_Value Has_OORO_PC_Value An association that shows which Authorized Values are possible for a specific ACC/AHA SARS2 Variable. A48 Conceptual Entity Has_ACC-AHA_SARS2_Authorized_Value Has_ACC-AHA_SARS2_Authorized_Value Has_ACC-AHA_SARS2_Authorized_Value true A property representing a concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus. NHC0 Conceptual Entity code code code A property that represents a description of the sort of thing or category to which a concept belongs in the context of the UMLS semantic network. P106 Conceptual Entity Semantic Type Semantic_Type In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS. Semantic_Type Semantic_Type A property representing an alternative Preferred Name for use in some NCI systems. P107 Conceptual Entity Display Name Display_Name Display Name Display_Name Display_Name A property representing the word or phrase that NCI uses by preference to refer to the concept. P108 Conceptual Entity Preferred Name Preferred_Name Preferred Name Preferred Term Preferred_Name Preferred_Name A property representing the concept unique identifier (CUI) assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept. P207 Conceptual Entity UMLS CUI UMLS_CUI UMLS_CUI UMLS_CUI A property representing the concept unique identifier (CUI) for those concepts that appear in NCI Metathesaurus but not in the National Library of Medicine Unified Medical Language System (NLM UMLS). P208 Conceptual Entity NCI Metathesaurus CUI NCI_META_CUI NCI_META_CUI NCI_META_CUI A property that is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake. P322 Conceptual Entity Contributing Source Contributing_Source Contributing_Source Contributing_Source A property representing the English language definition of a concept from a source other than NCI. P325 Conceptual Entity [source] Definition ALT_DEFINITION ALT_DEFINITION ALT_DEFINITION true A property representing a retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding. P366 Conceptual Entity Legacy Concept Name Legacy Concept Name Legacy_Concept_Name Legacy Concept Name A property representing that a term in another terminology has been mapped to a term in NCIt and describes the relationship between the mapped terms. P375 Conceptual Entity Maps_To Maps_To Maps_To A property representing notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept. P98 Conceptual Entity DesignNote DesignNote DesignNote DesignNote has_MedDRA_id ISA alternative term An alternative term used by the ISA tools project (http://isa-tools.org). Requested by Alejandra Gonzalez-Beltran https://sourceforge.net/tracker/?func=detail&aid=3603413&group_id=177891&atid=886178 Person: Alejandra Gonzalez-Beltran Person: Philippe Rocca-Serra ISA tools project (http://isa-tools.org) ISA alternative term NIAID GSCID-BRC alternative term An alternative term used by the National Institute of Allergy and Infectious Diseases (NIAID) Genomic Sequencing Centers for Infectious Diseases (GSCID) and Bioinformatics Resource Centers (BRC). PERSON: Chris Stoeckert, Jie Zheng NIAID GSCID-BRC metadata working group NIAID GSCID-BRC alternative term IEDB alternative term An alternative term used by the IEDB. PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters IEDB IEDB alternative term A subproperty of seeAlso that represents a NCIT identifier mapped to the specified term Oliver He term mapping to NCIT ID A subproperty of seeAlso that represents a UMLS CUI identifier mapped to the specified term Oliver He term mapping to UMLS CUI An annotation property that refers to a code defined by NCIT NCIT code alternative term in Chinese An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. temporal interpretation temporal interpretation https://oborel.github.io/obo-relations/temporal-semantics/ https://code.google.com/p/obo-relations/wiki/ROAndTime https://github.com/oborel/obo-relations/wiki/ROAndTime tooth SubClassOf 'never in taxon' value 'Aves' x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL. Chris Mungall ?X DisjointWith RO_0002162 some ?Y never in taxon An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon. taxonomic class assertion S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. RO:0002174 uberon dubious_for_taxon 1 1 dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost dubious_for_taxon S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S RO:0002175 applicable for taxon uberon present_in_taxon 1 1 present_in_taxon present_in_taxon An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL. logical macro assertion https://github.com/oborel/obo-relations/wiki/ShortcutRelations A logical macro assertion whose domain is an IRI for a class The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL logical macro assertion on a class A logical macro assertion whose domain is an IRI for a property logical macro assertion on a property logical macro assertion on an object property logical macro assertion on an annotation property relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q' Chris Mungall is direct form of An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. UBPROP:0000001 uberon external_definition 1 external_definition This annotation property may be replaced with an annotation property from an external ontology such as IAO external_definition A textual description of an axiom loss in this ontology compared to an external ontology. UBPROP:0000002 uberon axiom_lost_from_external_ontology 1 axiom_lost_from_external_ontology This annotation property may be replaced with an annotation property from an external ontology such as IAO axiom_lost_from_external_ontology Notes on the homology status of this class. UBPROP:0000003 uberon homology_notes 1 homology_notes This annotation property may be replaced with an annotation property from an external ontology such as IAO homology_notes Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. UBPROP:0000007 uberon has_relational_adjective 1 has_relational_adjective has_relational_adjective Notes on the how instances of this class vary across species. UBPROP:0000008 uberon taxon_notes 1 taxon_notes taxon_notes Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 uberon structure_notes 1 structure_notes structure_notes Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 uberon development_notes 1 development_notes development_notes Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 uberon external_ontology_notes 1 external_ontology_notes external_ontology_notes Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000013 uberon terminology_notes 1 terminology_notes terminology_notes A curated content resource is a web-resource that contains curated content about the ontology term. curated_content_resource true true This property is likely to change the ID. Please do not use in production systems. curated content resource excluded_subClassOf true excluded subClassOf should_conform_to true should_conform_to A metadata relation between a class and its taxonomic rank (eg species, family) ncbi_taxonomy has_rank Examples of a Contributor include a person, an organisation, or a service. Typically, the name of a Contributor should be used to indicate the entity. uberon dc-contributor 1 dc-contributor An entity responsible for making contributions to the content of the resource. Contributor Contributor contributor Examples of a Creator include a person, an organisation, or a service. Typically, the name of a Creator should be used to indicate the entity. An entity primarily responsible for making the content of the resource. Creator Creator Typically, Date will be associated with the creation or availability of the resource. Recommended best practice for encoding the date value is defined in a profile of ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format. A date associated with an event in the life cycle of the resource. Date Date Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content. An account of the content of the resource. Description Description Typically, Format may include the media-type or dimensions of the resource. Format may be used to determine the software, hardware or other equipment needed to display or operate the resource. Examples of dimensions include size and duration. Recommended best practice is to select a value from a controlled vocabulary (for example, the list of Internet Media Types [MIME] defining computer media formats). The physical or digital manifestation of the resource. Format Format The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system. A reference to a resource from which the present resource is derived. Source Source Typically, a Subject will be expressed as keywords, key phrases or classification codes that describe a topic of the resource. Recommended best practice is to select a value from a controlled vocabulary or formal classification scheme. The topic of the content of the resource. Subject and Keywords Subject and Keywords Mark Miller 2018-05-11T13:47:29Z has_alternative_id has_broad_synonym database_cross_reference A property representing a fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software. FULL_SYN Synonym with Source Data has exact synonym has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym id An association that connects the concept defining a particular terminology subset with concepts that belong to this subset. Concept_In_Subset in subset in_subset shorthand label label label http://www.w3.org/2000/01/rdf-schema#seeAlso seeAlso true true seeAlso seeAlso uberon foaf-depicted_by 1 foaf-depicted_by depicted_by is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. part_of BFO:0000050 uberon part_of part_of part of part of http://www.obofoundry.org/ro/#OBO_REL:part_of has part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'. has_part BFO:0000051 uberon has_part has_part has part has part bearer of bearer_of http://purl.obolibrary.org/obo/omrse.owl is bearer of is_bearer_of realized in this disease is realized in this disease course this fragility is realized in this shattering this investigator role is realized in this investigation is realized by realized_in http://purl.obolibrary.org/obo/ro.owl [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realized in realizes this disease course realizes this disease this investigation realizes this investigator role this shattering realizes this fragility to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realizes preceded by X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 is preceded by takes place after uberon preceded_by preceded_by preceded by preceded_by precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. BFO:0000063 uberon precedes precedes precedes precedes occurs in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t occurs_in unfolds in unfolds_in Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant occurs in site of [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant contains process span-of spanOf [copied from inverse property 'occupies temporal region'] p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) has temporal occupant x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer cjm 2009-07-31T02:15:46Z BSPO:0000096 uberon anterior_to anterior_to anterior_to x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000098 uberon dorsal_to dorsal_to dorsal_to x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000102 uberon ventral_to ventral_to ventral_to Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. BSPO:0000107 uberon deep_to deep_to deep_to Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. BSPO:0000108 uberon superficial_to superficial_to superficial_to X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. BSPO:0000124 uberon in_proximal_side_of in_proximal_side_of in_proximal_side_of X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. BSPO:0000125 uberon in_distal_side_of in_distal_side_of in_distal_side_of X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure BSPO:0000126 uberon in_lateral_side_of in_lateral_side_of in_lateral_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y BSPO:0001106 uberon proximalmost_part_of proximalmost_part_of proximalmost_part_of has measurement unit label This document is about information artifacts and their representations A (currently) primitive relation that relates an information artifact to an entity. is_about is a (currently) primitive relation that relates an information artifact to an entity. 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. We will try to build it back up by elaborating the various subproperties that are more precisely defined. Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. person:Alan Ruttenberg Smith, Ceusters, Ruttenberg, 2000 years of philosophy is about A person's name denotes the person. A variable name in a computer program denotes some piece of memory. Lexically equivalent strings can denote different things, for instance "Alan" can denote different people. In each case of use, there is a case of the denotation relation obtaining, between "Alan" and the person that is being named. A primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically denotes is a primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically 2009-11-10 Alan Ruttenberg. Old definition said the following to emphasize the generic nature of this relation. We no longer have 'specifically denotes', which would have been primitive, so make this relation primitive. g denotes r =def r is a portion of reality there is some c that is a concretization of g every c that is a concretization of g specifically denotes r person:Alan Ruttenberg Conversations with Barry Smith, Werner Ceusters, Bjoern Peters, Michel Dumontier, Melanie Courtot, James Malone, Bill Hogan denotes inverse of the relation 'denotes' Person: Jie Zheng, Chris Stoeckert, Mike Conlon denoted by relates a process to a time-measurement-datum that represents the duration of the process Person:Alan Ruttenberg is duration of An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased. an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. This is a shortcut relation of the following full version: 'has participant' some (participant 'has quality' ) in: process 'has participant' some (participant 'has quality' some quality) Yongqun He has participant quality a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. Yongqun He adverse event occurs in AE occurs in a specific 'preceded by' object property that has a domain of an adverse event. Yongqun He adverse event preceded by provides_service_consumer_with The provides_service_consumer_with relation links the service to its primary process it provides for the consumer (as opposed to secondary processual parts of a service process such as payment or documentation). For example, a 'DNA sequencing service' provides_service_consumer_with 'DNA sequencing' as the essential process performed by the provider for the client. A relation between a service and the primary processual part of the service that is performed by the provider for the consumer. provides_service_consumer_with is_supported_by_data The relation between the conclusion "Gene tpbA is involved in EPS production" and the data items produced using two sets of organisms, one being a tpbA knockout, the other being tpbA wildtype tested in polysacharide production assays and analyzed using an ANOVA. The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process OBI OBI Philly 2011 workshop is_supported_by_data has_specified_input has_specified_input see is_input_of example_of_usage A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. The inverse property of is_specified_input_of 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works. PERSON: Alan Ruttenberg PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Coutot has_specified_input is_specified_input_of some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. Alan Ruttenberg PERSON:Bjoern Peters is_specified_input_of has_specified_output has_specified_output A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. The inverse property of is_specified_output_of PERSON: Alan Ruttenberg PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Courtot has_specified_output is_specified_output_of is_specified_output_of A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. Alan Ruttenberg PERSON:Bjoern Peters is_specified_output_of is_specified_output_of achieves_planned_objective A cell sorting process achieves the objective specification 'material separation objective' This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. BP, AR, PPPB branch PPPB branch derived modified according to email thread from 1/23/09 in accordince with DT and PPPB branch achieves_planned_objective has grain the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car. Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form PERSON: Alan Ruttenberg PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349 has grain objective_achieved_by This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process. OBI OBI objective_achieved_by has organization member has value specification A relation between an information content entity and a value specification that specifies its value. PERSON: James A. Overton OBI has value specification BFO relation takes precedence. We anticipate BFO 2.0 including and defining this relation. When it does, we will obsolete this property and declare it equivalent to the BFO 2.0 relation. is-aggregate-of true A kidney biopsy protocol is executed in a kidney biopsy process. A shortcut relation that is concretized and realized in some process. Jie Zheng, Oliver He executed in A 'has part' object property that has the range of a textual question Oliver He has question form generated by An object property that indicates a relation between a question and an answer has answer to question has answer An object property that represents a relation between a form and a question where the question sets up an exclusion criterion. Specifically, when the answer to the question is Yes, the candidate becomes ineligible for the participation of a study. Fred Dowd, Oliver He has exclusion question An object property that represents a relation between a form and a question where the question sets up an inclusion criterion. Specifically, when the answer to the question is Yes, then the candidate fulfills a criterion for being eligible for participating in a study. Note that there might be other criteria that the candidate also need to meet in order to be fully eligible. Meanwhile, if the answer is No, the candidate may still be eligible depending on the other restriction. Fred Dowd, Oliver He has inclusion question has process quality An object property that represents a relation between a person with a biological sex and a process where the person has a specific susceptbility to a process Anthony Huffman, Oliver He has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding male population Anthony Huffman, Oliver He has increased susceptibility compared to male to Male has increased susceptibility to death due to COVID-19 infection compared to female. Note that in this case, the male can mean one single male individual. however, the female here means the whole female population. It is reported that the ratio of deaths in COVID-19 infected males to females is 1·21:1 in high-income countries, but 2·8:1 in low-income countries (Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023692/). An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding female population Anthony Huffman, Oliver He has increased susceptibility compared to female to An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to the whole population with all sexes included Anthony Huffman, Oliver He has increased sex-specific susceptibility compared to sex baseline to A care_site has a care_site_id (OMOP: http://ohdsi.github.io/CommonDataModel/cdm54.html#CARE_SITE) An object property that represents a relation between an entity and its corresponding identifier that is owned by the entity. Oliver He, Long Tran has identifier A patient was admitted to the hospital from home or a long-term care facility. An object property that represents a relation between a patient and a site from which the patient was admitted. Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE admitted from After a visit, a person was discharged to home or a long-term care site. Typically this applies only to visits that have a length of stay of a day or more. An object property that represents a relation between a patient and a site to which the patient was discharged after a visit. http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE discharged to An admission diagnosis status has the content of adimission diagnosis (as an information content entity). An object property that represents a relation between a status and an information content entity where the status has its content information defined by the information content entity. Oliver He, Long Tran has status content inheres in this fragility inheres in this vase this fragility is a characteristic of this vase this red color inheres in this apple this red color is a characteristic of this apple a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence A dependent inheres in its bearer at all times for which the dependent exists. 'inheres in at all times' inheres_in http://purl.obolibrary.org/obo/ro.owl Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. characteristic of inheres in bearer of this apple is bearer of this red color this vase is bearer of this fragility Inverse of characteristic_of a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer of bearer_of is bearer of bearer of bearer_of has characteristic is bearer of participates in this blood clot participates in this blood coagulation this input material (or this output material) participates in this process this investigator participates in this investigation a relation between a continuant and a process, in which the continuant is somehow involved in the process participates_in participates in has participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant http://purl.obolibrary.org/obo/ro.owl http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant has_participant concretizes A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant). An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process). A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. http://purl.obolibrary.org/obo/obi.owl It is recommended to not use this if possible in OMRSE. According to OntoBee this relation has been obsoleted and replaced with 'concretization of at all times'. As of Dec. 2, 2013 iao-main still uses this relation. concretizes this catalysis function is a function of this enzyme a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists. function_of is function of function of this investigator role is a role of this person a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists. is role of role_of role of this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. has_function has function this apple has quality this red color a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. has_quality has quality this person has role this investigator role (more colloquially: this person has this role of investigator) a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. has_role has role derives from this cell derives from this parent cell (cell division) this nucleus derives from this parent nucleus (nuclear division) a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'. derives_from derives from this parent cell derives into this cell (cell division) this parent nucleus derives into this nucleus (nuclear division) a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'. derives_into derives into is location of my head is the location of my brain this cage is the location of this rat a relation between two independent continuants, the location and the target, in which the target is entirely within the location Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime location_of RO:0001015 uberon location_of location_of location of location_of located in my brain is located in my head this rat is located in this cage a relation between two independent continuants, the target and the location, in which the target is entirely within the location Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime located_in http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 file:/Users/michaelashburner/Desktop/gaz/gaz.oboInOwl uberon located_in located_in located in located_in located_in (type level) RO:0002002 uberon has_boundary has_boundary has boundary RO:0002007 uberon bounding_layer_of bounding_layer_of A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. bounding layer of David Osumi-Sutherland <= Primitive instance level timing relation between events before or simultaneous with Relation between occurrents, shares start and end boundaries. David Osumi-Sutherland RO:0002082 coincides_with is_equal_to uberon simultaneous_with simultaneous_with t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) simultaneous with simultaneous_with David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) David Osumi-Sutherland starts_at_end_of A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]. RO:0002087 directly preceded by is directly preceded by is immediately preceded by starts_at_end_of uberon immediately_preceded_by immediately_preceded_by X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately preceded by immediately_preceded_by David Osumi-Sutherland ends_at_start_of meets X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) immediately precedes David Osumi-Sutherland io X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y)) starts during David Osumi-Sutherland d during X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) happens during David Osumi-Sutherland o overlaps X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). ends during x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) overlaps A is spatially_disjoint_from B if and only if they have no parts in common There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. Chris Mungall Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy BFO_0000051 exactly 0 (BFO_0000050 some ?Y) spatially disjoint from https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect) RO:0002176 uberon connects connects connects RO:0002202 uberon develops_from develops_from develops_from RO:0002203 uberon develops_into develops_into develops_into process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2. We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit Chris Mungall David Hill Tanya Berardini GO Regulation precludes parthood; the regulatory process may not be within the regulated process. regulates (processual) false regulates regulates (processual) mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974) osteoclast SubClassOf 'capable of' some 'bone resorption' A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. Chris Mungall has function realized in For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)". RO_0000053 some (RO_0000054 only ?Y) capable of c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. Chris Mungall has function in RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y)) capable of part of 'heart development' has active participant some Shh protein x has participant y if and only if x realizes some active role that inheres in y This may be obsoleted and replaced by the original 'has agent' relation Chris Mungall has agent has active participant x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y Chris Mungall RO:0002219 uberon surrounded_by surrounded_by surrounded by surrounded by surrounded_by A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts. The epidermis layer of a vertebrate is adjacent to the dermis. The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies. The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used. x adjacent to y if and only if x and y share a boundary. x adjacent_to y iff: x and y share a boundary This relation acts as a join point with BSPO Chris Mungall RO:0002220 uberon adjacent_to adjacent_to adjacent to adjacent_to inverse of surrounded by inverse of surrounded_by Chris Mungall RO:0002221 uberon surrounds surrounds surrounds surrounds Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to Relation between occurrents, shares a start boundary with. RO:0002223 uberon starts starts starts Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall started by RO:0002224 uberon starts_with starts_with starts with starts with Relation between occurrents, shares an end boundary with. RO:0002229 finishes uberon ends ends ends x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall finished by RO:0002230 uberon ends_with ends_with ends with ends with p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p. Chris Mungall consumes has input p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p. Chris Mungall produces has output RO:0002254 uberon has_developmental_contribution_from has_developmental_contribution_from has developmental contribution from t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. RO:0002256 uberon developmentally_induced_by developmentally_induced_by sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F) developmentally_induced_by RO:0002258 uberon developmentally_preceded_by developmentally_preceded_by developmentally preceded by RO:0002285 uberon developmentally_replaces developmentally_replaces developmentally_replaces q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w. Because part_of is transitive, inheres in is a sub-relation of inheres in part of Chris Mungall inheres in part of A mereological relationship or a topological relationship Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships mereotopologically related to a particular instances of akt-2 enables some instance of protein kinase activity Chris Mungall catalyzes executes has is catalyzing is executing This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized. This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time. enables Chris Mungall This is a grouping relation that collects relations used for the purpose of connecting structure and function functionally related to inverse of enables Chris Mungall enabled by inverse of regulates Chris Mungall regulated by (processual) regulated by An organism that is a member of a population of organisms is member of is a mereological relation between a item and a collection. is member of member part of SIO member of has member is a mereological relation between a collection and an item. SIO RO:0002351 uberon has_member has_member has member has member inverse of has input Chris Mungall input of inverse of has output Chris Mungall output of Chris Mungall formed as result of x has the potential to develop into y iff x develops into y or if x is capable of developing into y RO:0002387 uberon has_potential_to_develop_into has_potential_to_develop_into has potential to develop into This relation groups causal relations between material entities and causal relations between processes This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yield a cross-product of different relation types. Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causally related to p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain Chris Mungall causally upstream of p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q. Chris Mungall immediately causally upstream of p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q. We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2 Chris Mungall influences (processual) affects causally upstream of or within inverse of causally upstream of or within Chris Mungall causally downstream of or within RO:0002433 uberon contributes_to_morphology_of contributes_to_morphology_of contributes to morphology of 'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate' x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y. x composed_primarily_of y iff: more than half of the mass of x is made from parts of y Chris Mungall UBREL:0000002 RO:0002473 uberon composed_primarily_of composed_primarily_of composed primarily of Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. BFO:0000068 RO:0002488 begins_to_exist_during uberon existence_starts_during existence_starts_during existence starts during Relation between continuant and occurrent, such that c comes into existence at the start of p. RO:0002489 uberon existence_starts_with existence_starts_with existence starts with Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. BFO:0000069 RO:0002492 ceases_to_exist_during uberon existence_ends_during existence_ends_during existence ends during Relation between continuant and occurrent, such that c ceases to exist at the end of p. RO:0002493 uberon existence_ends_with existence_ends_with existence ends with RO:0002494 transforms from uberon transformation_of transformation_of transformation of RO:0002495 direct_transformation_of immediately transforms from uberon immediate_transformation_of immediate_transformation_of immediate transformation of RO:0002496 uberon existence_starts_during_or_after existence_starts_during_or_after existence starts during or after RO:0002497 uberon existence_ends_during_or_before existence_ends_during_or_before existence ends during or before A relationship between a material entity and a process where the material entity has some causal role that influences the process causal agent in p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between processes Chris Mungall depends on The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between material entities A coral reef environment is determined by a particular coral reef s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s. The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future Chris Mungall determined by (system to material entity) Chris Mungall Pier Buttigieg RO:0002507 uberon has_material_contribution_from has_material_contribution_from determined by has material contribution from inverse of determined by Chris Mungall determines (material entity to system) determines s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w. Chris Mungall determined by part of A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. RO:0002551 uberon has sekeletal support has supporting framework has_skeleton has_skeleton has skeleton Chris Mungall causally influenced by (material entity to material entity) causally influenced by Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b Chris Mungall causally influences (material entity to material entity) causally influences RO:0002572 uberon luminal_space_of luminal_space_of luminal space of RO:0002576 uberon skeleton_of skeleton_of skeleton of Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. Chris Mungall directly regulates (processual) directly regulates A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. Chris Mungall causal relation between material entity and a process Inverse of 'causal agent in' has causal agent A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. related via dependence to RO:0003000 uberon produces produces produces RO:0003001 uberon produced_by produced_by produced_by part_of carries uberon channel_for channel for x is a conduit for y iff y passes through the lumen of x. uberon conduit_for conduit for uberon existence_starts_and_ends_during existence starts and ends during X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides. uberon in_central_side_of in_central_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern uberon subdivision_of placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B subdivision of http://purl.org/obo/owl/relationship OBO_REL:0000007 relationship has_proper_part has_proper_part has measurement value The data type "last 4 digits of social security number" has digit number of 4. A data property that represents a relation between a data type and a number of integer digits that the data type has. Oliver He has digit number quality measured by year entity Entity entity Julius Caesar Verdi’s Requiem the Second World War your body mass index BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) entity continuant Continuant continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] continuant occurrent Occurrent occurrent An entity that has temporal parts and that happens, unfolds or develops through time. BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] occurrent ic IndependentContinuant a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism the bottom right portion of a human torso the interior of your mouth A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] independent continuant t-region TemporalRegion Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] temporal region process Process process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process disposition Disposition an atom of element X has the disposition to decay to an atom of element Y certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocytosis and exocytosis BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] disposition realizable RealizableEntity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] realizable entity quality Quality quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality sdc SpecificallyDependentContinuant specifically dependent continuant Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] specifically dependent continuant role Role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role fiat object fiat object part object-aggregate ObjectAggregate a collection of cells in a blood biobank. a swarm of bees is an aggregate of members who are linked together through natural bonds a symphony orchestra an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team) defined by fiat: the aggregate of members of an organization defined through physical attachment: the aggregate of atoms in a lump of granite defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container defined via attributive delimitations such as: the patients in this hospital the aggregate of bearings in a constant velocity axle joint the aggregate of blood cells in your body the nitrogen atoms in the atmosphere the restaurants in Palo Alto your collection of Meissen ceramic plates. An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee). ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158. b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004]) (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] object aggregate site Site Manhattan Canyon) a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] site object Object atom cell cells and organisms engineered artifacts grain of sand molecule organelle organism planet solid portions of matter star BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting. BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below). BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47 BFO 2 Reference: an object is a maximal causally unified material entity BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74 b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001]) object gdc GenericallyDependentContinuant The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] generically dependent continuant function Function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] function 1d-t-region OneDimensionalTemporalRegion the temporal region during which a process occurs. BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks). A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] one-dimensional temporal region material MaterialEntity material entity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] material entity immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial entity process-profile ProcessProfile On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance. The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on. b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005]) (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] process profile 0d-t-region ZeroDimensionalTemporalRegion a temporal region that is occupied by a process boundary right now the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. temporal instant. A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] zero-dimensional temporal region history History A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001]) history Material anatomical entity that is a member of an individual species or is a viral or viroid particle. organism or virus or viroid A cardiovascular drug that tends to raise reduced blood pressure. Wikipedia:Antihypotensive_agent chebi_ontology antihypotensive agents pressor pressors vasopressor agens vasopressor agent CHEBI:137431 antihypotensive agent peptide Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. peptide Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6. 0 C9H11N2O4SR 243.26000 243.04395 [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC([*])=O)C(O)=O CHEBI:14742 CHEBI:25869 CHEBI:7961 CiteXplore:12833570 CiteXplore:1502708 CiteXplore:16033609 CiteXplore:7798534 KEGG COMPOUND:C00395 KEGG:C00395 PMID:11851248 PMID:12833570 PMID:1502708 PMID:16033609 PMID:7061385 PMID:7798534 Wikipedia:Penicillin Penicillin penicillin penicillins chebi_ontology C9H11N2O4SR [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC([*])=O)C(O)=O penicillins CHEBI:17334 penicillin A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy. 0 C7H5NO3SR2 183.18500 182.99901 [H][C@]12SCC([*])=C(N1C(=O)[C@H]2[*])C(O)=O CHEBI:3538 CiteXplore:12833570 CiteXplore:6762896 KEGG COMPOUND:C00875 KEGG:C00875 PMID:10069359 PMID:11936371 PMID:12833570 PMID:24269048 PMID:3320614 PMID:6762896 PMID:8426246 Wikipedia:Cephalosporin Cephalosporin chebi_ontology C7H5NO3SR2 [H][C@]12SCC([*])=C(N1C(=O)[C@H]2[*])C(O)=O cephalosphorin cephalosphorins cephalosporins CHEBI:23066 cephalosporin molecular entity Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. We are assuming that every molecular entity has to be completely connected by chemical bonds. This excludes protein complexes, which are comprised of minimally two separate molecular entities. We will follow up with Chebi to ensure this is their understanding as well molecular entity chebi_ontology entidad molecular entidades moleculares entite moleculaire molecular entities molekulare Entitaet CHEBI:23367 molecular entity cyclic amide cyclic amides CHEBI:23443 cyclic amide A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. chemical entity chebi_ontology CHEBI:24431 chemical entity CHEBI:24531 heterocyclic antibiotic A cyclic compound having as ring members atoms of carbon and at least of one other element. chebi_ontology organic heterocycle organic heterocyclic compounds CHEBI:24532 organic heterocyclic compound Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)). chebi_ontology CHEBI:24651 hydroxides A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). oxoacid oxoacids oxacids oxiacids oxo acid oxy-acids oxyacids CHEBI:24833 oxoacid Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. lactam lactams chebi_ontology Laktam Laktame lactams CHEBI:24995 lactam Any polyatomic entity that is an electrically neutral entity consisting of more than one atom. molecule chebi_ontology Molekuel molecula molecules neutral molecular compounds CHEBI:25367 molecule chebi_ontology organonitrogen heterocyclic antibiotics CHEBI:25558 organonitrogen heterocyclic antibiotic oxygen molecular entity chebi_ontology oxygen molecular entities CHEBI:25806 oxygen molecular entity chebi_ontology CHEBI:25865 penicillanic acids sulfur molecular entity sulfur molecular entities CHEBI:26835 sulfur molecular entity chebi_ontology heterobicyclic compounds organic heterobicyclic compounds CHEBI:27171 organic heterobicyclic compound An organonitrogen heterocyclic antibiotic that contains a beta-lactam ring. CHEBI:10427 CHEBI:22844 KEGG:C03438 PMID:19254642 PMID:22594007 Wikipedia:Beta-lactam_antibiotic chebi_ontology beta-Lactam antibiotics beta-lactam antibiotics CHEBI:27933 beta-lactam antibiotic An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. CHEBI:22473 CHEBI:2633 KEGG COMPOUND:C00241 KEGG:C00241 Amide amides chebi_ontology CHEBI:32988 amide atom A chemical entity constituting the smallest component of an element having the chemical properties of the element. atom An organosulfur compound is a compound containing at least one carbon-sulfur bond. CHEBI:23010 CHEBI:25714 Wikipedia:Organosulfur_compounds organosulfur compound chebi_ontology organosulfur compounds CHEBI:33261 organosulfur compound A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. chebi_ontology heteroorganic entities organoelement compounds CHEBI:33285 heteroorganic entity pnictogen molecular entity pnictogen molecular entities CHEBI:33302 pnictogen molecular entity Any p-block molecular entity containing a chalcogen. chalcogen molecular entity chebi_ontology chalcogen compounds chalcogen molecular entities CHEBI:33304 chalcogen molecular entity A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. An oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. 0 CHO2R 45.01740 44.99765 OC([*])=O CHEBI:13428 CHEBI:13627 CHEBI:23027 CiteXplore:17147560 CiteXplore:18433345 PMID:17147560 PMID:18433345 Wikipedia:Carboxylic_acid carboxylic acid carboxylic acids chebi_ontology CHO2R Carbonsaeure Carbonsaeuren Karbonsaeure OC([*])=O RC(=O)OH acide carboxylique acides carboxyliques acido carboxilico acidos carboxilicos CHEBI:33575 carboxylic acid A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. chebi_ontology main group compounds main group molecular entities CHEBI:33579 main group molecular entity carbon group molecular entity carbon group molecular entities CHEBI:33582 carbon group molecular entity Any molecule that consists of a series of atoms joined together to form a ring. Wikipedia:Cyclic_compound chebi_ontology cyclic compounds CHEBI:33595 cyclic compound hydrogen compounds hydrogen molecular entities CHEBI:33608 hydrogen molecular entity A molecule that features two fused rings. bicyclic compounds CHEBI:33636 bicyclic compound A polycyclic compound in which at least one of the rings contains at least one non-carbon atom. heteropolycyclic compounds chebi_ontology polyheterocyclic compounds CHEBI:33671 heteropolycyclic compound A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom. heterobicyclic compounds chebi_ontology CHEBI:33672 heterobicyclic compound An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element. s-block molecular entity s-block compounds s-block molecular entities CHEBI:33674 s-block molecular entity A main group molecular entity that contains one or more atoms of a p-block element. A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element. chebi_ontology p-block compounds p-block molecular entities p-block molecular entitiy CHEBI:33675 p-block molecular entity nucleic acid A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. nucleic acid Any organic molecule that consists of atoms connected in the form of a ring. chebi_ontology organic cyclic compounds CHEBI:33832 organic cyclic compound macromolecule A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. polymer macromolecule Any heteroorganic entity containing at least one carbon-nitrogen bond. organonitrogen compounds chebi_ontology organonitrogens CHEBI:35352 organonitrogen compound chebi_ontology carbon oxoacids oxoacids of carbon CHEBI:35605 carbon oxoacid A beta-lactam is a lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon. A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon. 0 C3H2NOR3 68.054 68.01364 C1(C(N(*)C1*)=O)* CHEBI:10426 CHEBI:13203 CHEBI:22845 KEGG COMPOUND:C01866 KEGG:C01866 Wikipedia:Beta-lactam beta-Lactam beta-lactam chebi_ontology a beta-lactam beta-lactams CHEBI:35627 beta-lactam Natural and synthetic antibiotics containing the 4-thia-1-azabicyclo[3.2.0]heptan-7-one structure, generally assumed to have the 5R configuration unless otherwise specified. penams chebi_ontology CHEBI:35992 penams Any molecular entity consisting of more than one atom. chebi_ontology polyatomic entities CHEBI:36357 polyatomic entity pseudoketone pseudoketones pseudoketones CHEBI:36585 pseudoketone Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives. carbonyl compounds chebi_ontology CHEBI:36586 carbonyl compound Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element. oxo compounds organic oxo compounds CHEBI:36587 organic oxo compound A cyclic compound in which a carbonyl group in a ring is bonded to one or two skeletal heteroatoms. cyclic pseudoketones CHEBI:36588 cyclic pseudoketone An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. organochalcogen compound chebi_ontology organochalcogen compounds CHEBI:36962 organochalcogen compound An organochalcogen compound containing at least one carbon-oxygen bond. CiteXplore:17586126 PMID:17586126 organooxygen compound chebi_ontology organooxygen compounds CHEBI:36963 organooxygen compound A molecular entity consisting of two or more chemical elements. chemical compound heteroatomic molecular entities CHEBI:37577 heteroatomic molecular entity An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom. 0 CNOR3 42.01680 41.99799 [*]C(=O)N([*])[*] CHEBI:35354 CHEBI:35355 carboxamides chebi_ontology carboxamides primary carboxamide CHEBI:37622 carboxamide Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms. chebi_ontology heterocyclic organonitrogen compounds organonitrogen heterocyclic compounds CHEBI:38101 organonitrogen heterocyclic compound chebi_ontology heterocyclic organosulfur compounds organosulfur heterocyclic compounds CHEBI:38106 organosulfur heterocyclic compound CHEBI:25429 CHEBI:38075 chebi_ontology organic heteropolycyclic compounds CHEBI:38166 organic heteropolycyclic compound chebi_ontology cephems CHEBI:38311 cephem Any molecular entity that contains carbon. CHEBI:25700 CHEBI:33244 chebi_ontology organic compounds organic entity organic molecular entities CHEBI:50860 organic molecular entity CHEBI:25556 CHEBI:7594 KEGG COMPOUND:C06061 KEGG:C06061 chebi_ontology Nitrogenous compounds nitrogen compounds nitrogen molecular entities CHEBI:51143 nitrogen molecular entity A cyclic compound having as ring members atoms of at least two different elements. Heterocyclic compound chebi_ontology compuesto heterociclico compuestos heterociclicos heterocycle heterocyclic compounds CHEBI:5686 heterocyclic compound Any molecule that consists of at least one carbon atom as part of the electrically neutral entity. chebi_ontology organic compound organic compounds organic molecules CHEBI:72695 organic molecule cell cell PMID:18089833.Cancer Res. 2007 Dec 15;67(24):12018-25. "...Epithelial cells were harvested from histologically confirmed adenocarcinomas .." A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. cell cell cultured cell A cell in vitro that is or has been maintained or propagated as part of a cell culture. cultured cell experimentally modified cell in vitro A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure. experimentally modified cell in vitro A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation. clinical_measurement_ontology CMO:0000000 clinical measurement Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels. EFO:0004298 EFO:0006919 cardiovascular event measurement clinical_measurement_ontology CMO:0000001 cardiovascular measurement The number of contractions of the cardiac ventricles per unit of time. EFO:0004326 EFO:0004351 VT:2000009 resting heart rate clinical_measurement_ontology CMO:0000002 heart rate Measurement of the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood. EFO:0004325 blood pressure clinical_measurement_ontology Not4Curation CMO:0000003 blood pressure measurement The maximum arterial pressure within the cardiac cycle, i.e. at the point at which the heart is in its maximal state of contraction. This is the time when the blood is forced from the ventricles of the heart into the pulmonary artery and the aorta. EFO:0006335 VT:2000000 clinical_measurement_ontology CMO:0000004 systolic blood pressure The minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood. EFO:0006336 VT:2000000 clinical_measurement_ontology CMO:0000005 diastolic blood pressure The minimum pressure in the heart left ventricle, usually at the point at which the heart is in a state of relaxation and expansion and the ventricles fill with blood. VT:0010750 LVDP clinical_measurement_ontology CMO:0000006 left ventricular diastolic blood pressure Measurement of the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta. LVP LVPmax peak left ventricular pressure clinical_measurement_ontology CMO:0000007 left ventricular systolic blood pressure A blood pressure measurement which has been normalized or adjusted by a mathematical process or computation. Blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood. clinical_measurement_ontology Not4Curation CMO:0000008 calculated blood pressure The average blood pressure within an artery over a specified period of time. It is often calculated using the formula of one third systolic pressure plus two thirds diastolic pressure, or alternatively, using the formula diastolic pressure plus 1/3 of the difference between systolic pressure and diastolic pressure (i.e. 1/3 pulse pressure). EFO:0006340 VT:2000000 mean arterial pressure clinical_measurement_ontology CMO:0000009 mean arterial blood pressure A calculated value for the difference between the systolic blood pressure and the diastolic blood pressure at a given point in time when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled. clinical_measurement_ontology CMO:0000010 developed blood pressure Morphological measurement involving the entire body of an organism. clinical_measurement_ontology CMO:0000011 whole body morphological measurement The heaviness or degree to which an entire organism's body is drawn to the earth by gravity. EFO:0004338 VT:0001259 clinical_measurement_ontology body mass CMO:0000012 body weight The level of heat in an organism. VT:0005535 clinical_measurement_ontology CMO:0000015 body temperature A measurement of the physical form or structure of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system. clinical_measurement_ontology CMO:0000016 This is the term which was just "heart measurement". Since it was under body morphological measurement it seemed to clearly refer to a morphological measurement. I made this term more specific so that another term for "heart measurement" could be added to the ontology above it which would also be a parent to other non-morphological heart-related terms. JRS 2-15-2012. heart morphological measurement The heaviness of the heart (the central cardiac muscle which maintains the circulation of the blood) or the degree to which it is drawn to the earth by gravity. VT:0007028 clinical_measurement_ontology CMO:0000017 heart weight A calculated measurement of the difference between the systolic pressure and the diastolic pressure in the heart left ventricle at a given point in time in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled. VT:2000009 clinical_measurement_ontology CMO:0000018 left ventricular developed pressure Measurement of the structure or forms of the entire body or parts of the body of an organism. EFO:0004302 EFO:0004324 body weights and measures clinical_measurement_ontology anthropometric measurement morphometry CMO:0000021 body morphological measurement A quantification of a parameter of the chemical composition of blood. clinical_measurement_ontology blood molecular composition measurement CMO:0000023 blood chemistry measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of one or more of the various, specific types of leukocytes present in a sample of blood for which a total white blood cell count was taken, usually 1 cubic mm of peripheral venous blood. mshimoyama 2010-12-13T10:32:58Z clinical_measurement_ontology calculated blood differential WBC count calculated blood differential leukocyte count CMO:0000024 calculated differential white blood cell count The amount of hemoglobin, the red oxygen-carrying pigment of erythrocytes, in a specified volume of blood. CMO:0000506 VT:0001588 hemoglobin concentration clinical_measurement_ontology hemoglobin absorbance CMO:0000026 blood hemoglobin level The number of white blood cells in a specified volume of blood. EFO:0004308 EFO:0007988 VT:0000217 myeloid white cell count clinical_measurement_ontology leukocyte count white corpuscle count CMO:0000027 white blood cell count Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in blood. total blood protein measurement EFO:0004536 EFO:0005105 EFO:0007937 VT:0005416 clinical_measurement_ontology CMO:0000028 blood protein measurement The number of platelets (thrombocytes) in a specified volume of blood, usually expressed as platelets per cubic millimeter of whole blood. EFO:0004309 VT:0003179 clinical_measurement_ontology CMO:0000029 platelet count A measurement of the blood, it's contents, cells or other factors contained within the blood. EFO:0004503 hematological measurement clinical_measurement_ontology CMO:0000035 blood measurement Value resulting from the quantification of the cellular elements of the blood, including morphological parameters of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. The CBC/differential indicates the differential counts of white blood cells, counts of red blood cells and platelets, the concentration of hemoglobin, and the hematocrit. CBC blood test CBC, differential CMO:0000364 clinical_measurement_ontology CBC Not4curation CMO:0000036 complete blood count and differential The level of urea in the blood in terms of nitrogen content; converted to urea concentration by multiplying by 60/28 or 2.14. Urea is the chief nitrogenous end product of protein metabolism in whole blood. Urea is formed in the liver from amino acids and from ammonia compounds and can be found in urine, blood, and lymph. EFO:0004741 VT:0005265 blood urea nitrogen measurement clinical_measurement_ontology BUN level CMO:0000049 blood urea nitrogen level Any value resulting from the quantification of a morphological or physiological parameter of a blood-derived lipid, any of a structurally diverse group of organic compounds found in blood that are insoluble in water but soluble innonpolar solvents that, among other biological functions, serve as a source of fuel and are an important constituent of cell structure. lipid or lipoprotein measurement EFO:0004529 EFO:0005105 EFO:0006811 EFO:0008350 lipid measurement alpha-linoleic acid measurement linolenic acid measurement clinical_measurement_ontology CMO:0000050 blood lipid measurement Measurement of the entire amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, without taking into account any association with other molecules such as lipoproteins, in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. EFO:0004574 EFO:0007806 VT:0000180 total cholesterol measurement total cholesterol change measurement clinical_measurement_ontology blood TC level CMO:0000051 blood total cholesterol level Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in high-density lipoprotein (HDL) molecules in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. HDL is the smallest of the major lipoprotein particles, complex molecules that consist of a protein membrane surrounding a core of lipids. The HDL class of lipoproteins, specifically the subtypes of HDL2 and HDL3, have densities between 1.063 and 1.210 g/ml. EFO:0004612 EFO:0007805 EFO:0022157 VT:0000184 blood HDL-C high density lipoprotein cholesterol measurement HDL cholesterol change measurement free cholesterol in large HDL measurement clinical_measurement_ontology blood HDL level CMO:0000052 Values for density ranges of the lipoprotein classes are approximate. The classes may be defined differently by different researchers, in part because class definitions depend on the number of subclasses into which the lipoprotein fractions are divided. blood high density lipoprotein cholesterol level Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in low-density lipoprotein (LDL) molecules in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. LDL constitute a class of relatively large, heterogeneous lipoprotein particles, complex molecules that consist of a protein membrane surrounding a core of lipids. The LDL class of lipoproteins has a density between 1.019 and 1.063 g/ml. In some animal species, such as canine and rodents, this may overlap with the HDL1 class and be designated LDL/HDL1. EFO:0004611 EFO:0007804 VT:0000181 low density lipoprotein cholesterol measurement LDL cholesterol change measurement clinical_measurement_ontology blood LDL level blood LDL-C level CMO:0000053 Values for density ranges of the lipoprotein classes are approximate. The classes may be defined differently by different researchers, in part because class definitions depend on the number of subclasses into which the lipoprotein fractions are divided. blood low density lipoprotein cholesterol level Measurement of the total amount of all proteins, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, found in a specific volume of plasma, the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. VT:0005567 clinical_measurement_ontology CMO:0000054 plasma total protein level A quantification of one or more mineral salts found in the blood in the form of electrically charged ions. clinical_measurement_ontology CMO:0000063 blood electrolyte measurement Any quantitation of the catalytic effect exerted by an enzyme in a specified sample of blood. An enzyme is a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reaction(s). clinical_measurement_ontology Not4Curation CMO:0000064 blood enzyme activity level A measurement of the physical form and structure of an organ. clinical_measurement_ontology Not4Curation CMO:0000068 This is the term which used to be just "organ measurement". Since it was under body morphological measurement, it clearly referred to a morphological measurement. Because a term for organ measurement was needed that was not morphological, and since this one already had annotations, I changed the term while keeping the ID and location in the ontology the same. JRS 2-15-2012. organ morphological measurement The weight of the heart after removal from the body but without desiccation. VT:0007028 clinical_measurement_ontology CMO:0000069 heart wet weight The weight of the heart after desiccation. clinical_measurement_ontology CMO:0000070 heart dry weight The weight of the lower left chamber of the heart, which pumps oxygenated blood through the aorta into the systemic arteries, after removal from the body and separation from the rest of the heart but without desiccation. CMO:0000655 VT:0007031 clinical_measurement_ontology CMO:0000071 heart left ventricle wet weight The weight of the lower right chamber of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, after removal from the body and separation from the rest of the heart but without desiccation. CMO:0000624 VT:0007033 clinical_measurement_ontology CMO:0000072 heart right ventricle wet weight This is a measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the weight of the heart, that is, its heaviness or the degree to which it is drawn toward the earth by gravity. VT:0007028 clinical_measurement_ontology CMO:0000073 calculated heart weight A calculated value in which the weight of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system, is divided by the total weight of the body, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism. CMO:0000075 VT:0007028 heart weight as percentage of body weight clinical_measurement_ontology CMO:0000074 heart weight to body weight ratio The weight of the aorta, the main trunk from which the arterial system proceeds. Weight is the heaviness or degree to which a body is drawn to the earth by gravity. clinical_measurement_ontology CMO:0000076 aorta weight Any quantification of a morphological or physiological parameter of one or more blood vessels, the network of muscular tubes that carry blood through the body. clinical_measurement_ontology CMO:0000077 blood vessel measurement This is any measurement, morphological or physiological, involving the kidney or any of the organs involved in the production or excretion of urine. EFO:0004742 renal system measurement clinical_measurement_ontology CMO:0000080 renal/urinary measurement The weight of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. VT:0002707 clinical_measurement_ontology CMO:0000081 kidney weight The weight of the right kidney, the organ which lies on the right side of the body from the perspective of the subject and functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation. VT:0002707 clinical_measurement_ontology CMO:0000082 right kidney wet weight The weight of the left kidney, the organ which lies on the left side of the body from the perspective of the subject and functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation. VT:0002707 clinical_measurement_ontology CMO:0000083 left kidney wet weight The weight of a single kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation. VT:0002707 individual kidney wet weight clinical_measurement_ontology CMO:0000084 single kidney wet weight The weight of both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation. VT:0002707 clinical_measurement_ontology CMO:0000085 both kidneys wet weight Measurement of the physical form or structure of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. renal morphological measurement clinical_measurement_ontology CMO:0000087 kidney morphological measurement Measurement of adipose tissue in entire body or region of body of an organism. mshimoyama 2010-06-23T04:14:20Z EFO:0004341 EFO:0004764 adipose tissue measurement body fat distribution clinical_measurement_ontology CMO:0000089 body fat morphological measurement Measurement of the physical form or structure of the liver, the large abdominal organ/gland which functions in the storage and filtration of blood, secretion of bile, detoxification of noxious substances, synthesis and storage of glycogen, synthesis and breakdown of fats and temporary storage of fatty acids, and synthesis of serum proteins. clinical_measurement_ontology CMO:0000093 liver morphological measurement A measurement relating body weight to height in an organism; typically calculated as the weight of an individual divided by the height of that individual squared. For quadrupeds, the square of body height is often replaced by the square of body length. EFO:0004340 EFO:0005851 EFO:0005935 EFO:0005936 EFO:0005937 EFO:0007041 VT:0001259 BMI body mass index height-adjusted body mass index longitudinal BMI measurement overweight body mass index status underweight body mass index status clinical_measurement_ontology obese body mass index status CMO:0000105 body mass index The vertical measurement of a body. EFO:0004339 EFO:0005201 EFO:0006784 EFO:0006785 body height at birth infant body height clinical_measurement_ontology height growth measurement CMO:0000106 body height A measurement that indicates the compositional nature of a tissue or set of tissues. mshimoyama 2009-12-17T10:53:44Z clinical_measurement_ontology CMO:0000107 tissue composition measurement A calculated value which compares the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, with the weight of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, and presents it as a ratio. mshimoyama 2009-12-17T08:17:35Z VT:0007033 clinical_measurement_ontology CMO:0000108 heart right ventricle weight to left ventricle weight ratio The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter. mshimoyama 2009-12-17T08:22:51Z EFO:0005090 EFO:0007987 VT:0000334 granulocyte count clinical_measurement_ontology CMO:0000111 blood granulocyte count The amount of triglycerides in a specific volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. Triglycerides are any of a group of lipids that are esters formed from one molecule of glycerol and three molecules of one or more fatty acids, are widespread in adipose tissue, and commonly circulate in the blood in the form of lipoproteins. mshimoyama 2009-12-17T10:19:44Z triglyceride measurement EFO:0004530 EFO:0007681 VT:0002644 triglyceride change measurement clinical_measurement_ontology CMO:0000118 blood triglyceride level The amount of lipoproteins, any of a group of conjugated proteins that have at least one lipid component, in a specific volume of blood. mshimoyama 2009-12-17T10:21:58Z clinical_measurement_ontology CMO:0000119 blood lipoprotein level The amount of bilirubin found in a specific volume of blood. mshimoyama 2009-12-17T10:35:20Z VT:0001569 clinical_measurement_ontology CMO:0000123 blood bilirubin level Measurement of the amount of creatinine in a specified sample of urine, the fluid waste product excreted by the kidneys. Creatinine is a nitrogenous compound formed in muscle as the end product of creatine metabolism. Blood and urine tests for creatinine are used as diagnostic indicators of kidney function and muscle mass. mshimoyama 2009-12-17T11:00:47Z CHEBI:16737 VT:0010540 clinical_measurement_ontology CMO:0000125 urine creatinine level Any measurement of the physical form or structure of the skeletal, smooth and/or heart muscles of the body. mshimoyama 2010-06-24T01:24:08Z clinical_measurement_ontology CMO:0000127 muscle morphological measurement The amount of albumin in a specified volume of urine. Urine albumin levels which are above normal but not detectable with routine protein testing are referred to as microalbuminuria. mshimoyama 2009-12-17T11:01:46Z EFO:0010967 VT:0002871 urinary microalbumin measurement clinical_measurement_ontology urine microalbumin level CMO:0000130 urine albumin level Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the weight of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. rnigam 2010-05-25T04:01:05Z VT:0002707 clinical_measurement_ontology Not4Curation CMO:0000160 calculated kidney weight The weight of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation. rnigam 2010-05-25T04:11:18Z VT:0002707 clinical_measurement_ontology CMO:0000169 kidney wet weight The weight after desiccation of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. rnigam 2010-05-25T04:11:36Z clinical_measurement_ontology CMO:0000170 kidney dry weight The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at either the inner surface or outer surface of the blood vessel wall. mshimoyama 2010-06-10T09:05:26Z clinical_measurement_ontology CMO:0000179 blood vessel diameter Percentage of blood pumped out of the left ventricle with each heart beat. mshimoyama 2010-06-10T09:06:25Z EF EFO:0005527 EFO:0008373 PMID:32207065 VT:2000009 LVEF ejection fraction measurement heart left ventricle ejection fraction left ventricle ejection fraction left ventricular ejection fraction left ventricular ejection fraction measurement clinical_measurement_ontology CMO:0000180 ejection fraction Volume of blood in left ventricle at end of contraction. mshimoyama 2010-06-10T09:08:28Z PMID:12957726 VT:2000009 ESV clinical_measurement_ontology CMO:0000181 end-systolic volume Any measurement of the movement of blood through the heart and blood vessels. mshimoyama 2010-06-10T09:38:29Z clinical_measurement_ontology blood flow measurement CMO:0000195 circulation measurement The volume of blood flowing through a vessel or organ per unit of time. mshimoyama 2010-06-10T09:38:42Z clinical_measurement_ontology CMO:0000196 blood flow rate The volume of blood pumped from the right or left ventricle per minute, also used to calculate - stroke volume X heart rate. mshimoyama 2010-06-10T09:51:29Z VT:0010486 clinical_measurement_ontology CMO:0000197 cardiac output The volume of blood flowing through an artery per unit time. mshimoyama 2010-06-10T09:56:23Z VT:0000261 clinical_measurement_ontology CMO:0000198 arterial blood flow rate The volume of blood passing through a vein per unit time. mshimoyama 2010-06-10T09:56:38Z clinical_measurement_ontology CMO:0000199 venous blood flow rate This is a measurement of the tangential force of the flowing blood on the endothelial surface of the blood vessel. The value is defined by the Hagen-Poiseuille equation (τ = 4μQ/πR3, where τ is the shear stress, μ is the blood viscosity, Q is the volumetric flow rate, and R is the lumen radius). mshimoyama 2010-06-10T10:04:04Z blood vessel shear stress measurement clinical_measurement_ontology CMO:0000201 vessel shear stress measurement This is a measurement of the tangential force of flowing blood on the endothelial surface of an in vitro blood vessel or other experimental support. The experimental set-up may use steady, nonpulsatile laminar shear stress, pulsatile laminar shear stress, or nonlaminar oscillatory shear stress. mshimoyama 2010-06-10T10:51:43Z in vitro blood vessel shear stress clinical_measurement_ontology CMO:0000202 in vitro vessel shear stress This is a measurement of shear stress in a model organism by the experimental creation of an arteriovenous fistula, ligation of vessels, or transposition of a vein graft into the arterial circulation. mshimoyama 2010-06-10T10:52:06Z in vivo blood vessel shear stress clinical_measurement_ontology CMO:0000203 in vivo vessel shear stress Measurement of coagulation and factors affecting coagulation in blood after removal from the living organism. mshimoyama 2010-06-10T11:01:19Z clinical_measurement_ontology CMO:0000206 in vitro coagulation measurement The time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent. It is used to evaluate the intrinsic clotting system. mshimoyama 2010-06-10T11:20:31Z EFO:0004310 VT:0002551 partial thromboplastin time clinical_measurement_ontology CMO:0000210 activated partial thromboplastin time Measurement of the clotting ability of fibrinogen, prothrombin, proaccelerin, proconvertin and Stuart factor, usually given in seconds to formation of clot after the addition of a tissue factor or thromboplastin. mshimoyama 2010-06-10T11:21:04Z EFO:0008390 VT:0002551 prothrombin time measurement clinical_measurement_ontology CMO:0000211 prothrombin time mshimoyama 2010-06-10T02:02:16Z clinical_measurement_ontology vasodilation measurement CMO:0000215 blood vessel dilation measurement mshimoyama 2010-06-10T02:02:34Z clinical_measurement_ontology CMO:0000216 lumen diameter at maximum dilation expressed as percent of baseline mshimoyama 2010-06-10T02:34:30Z clinical_measurement_ontology vasoconstriction measurement CMO:0000218 blood vessel constriction measurement mshimoyama 2010-06-10T02:35:20Z VT:0001614 clinical_measurement_ontology CMO:0000219 lumen diameter at maximum constriction expressed as percent of baseline Resistance to blood flow by blood vessels throughout the body, the degree to which the blood vessels impede the flow of blood, often calculated as SVR equal to the difference between mean arterial blood pressure (MAP) and central venous pressure (CVP) divided by cardiac output (CO) (SVR=MAP &#8722; CVP/CO). mshimoyama 2010-06-10T02:41:52Z PMID:22258067 VT:0000261 SVR TPR total peripheral resistance clinical_measurement_ontology CMO:0000220 systemic vascular resistance Volume of blood in left ventricle immediately before a contraction. mshimoyama 2010-06-10T03:56:38Z PMID:12957726 VT:2000009 EDV clinical_measurement_ontology CMO:0000221 end-diastolic volume Volume of blood pumped from one ventricle of the heart with each beat, calculated by subtracting the volume of blood in the ventricle at the end of a beat (end-systolic volume) from the volume of blood just prior to the beat (end-diastolic volume). mshimoyama 2010-06-11T01:32:10Z VT:2000009 SV clinical_measurement_ontology CMO:0000223 stroke volume Any quantification of a morphological or physiological parameter of one or more cells. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning. mshimoyama 2010-06-17T10:30:36Z clinical_measurement_ontology CMO:0000227 cell measurement Number of cells of muscular tissue in the heart in a specified sample size. mshimoyama 2010-06-17T10:30:50Z clinical_measurement_ontology CMO:0000228 cardiomyocyte count The enumeration, i.e. measurement of the total number, of the specialized liner cells that form an interface between the circulating blood and the rest of the vessel wall in a specified sample of blood vessel, any one of the network of muscular tubes that carry blood through the body. mshimoyama 2010-06-17T10:33:11Z blood vessel endothelial cell number vascular endothelial cell count clinical_measurement_ontology CMO:0000229 blood vessel endothelial cell count Any measurement of components of the electrical conduction system of the heart.The electrical conduction system of the heart transmits signals generated usually by the sinoatrial node to cause contraction of the heart muscle. mshimoyama 2010-06-17T10:36:15Z EFO:0007885 JT interval clinical_measurement_ontology CMO:0000230 heart electrical conduction measurement Interval between an R wave and the next R wave of successive heart beats, inverse of the heart rate. mshimoyama 2010-06-17T10:39:30Z EFO:0004831 VT:2000017 clinical_measurement_ontology RR_Interval CMO:0000232 RR interval Time between the beginning of the P wave to the beginning of the QRS complex, reflects the time the electrical impulse takes to travel from the sinus node through the AV node and entering the ventricles, used as an estimate of AV node function. mshimoyama 2010-06-17T10:40:52Z EFO:0004462 EFO:0005095 VT:2000017 PQ Interval PR segment clinical_measurement_ontology CMO:0000233 PR interval The time between the J point ( the point at which the QRS complex finishes and the ST segment begins) to the end of the T wave. mshimoyama 2010-06-17T10:43:21Z VT:2000017 clinical_measurement_ontology ST_Interval CMO:0000234 ST interval An interval measured from the onset of the QRS wave complex to the offset of the T wave. mshimoyama 2010-06-17T10:45:44Z EFO:0004682 VT:2000017 clinical_measurement_ontology QT_Interval CMO:0000235 QT interval mshimoyama 2010-06-17T10:53:08Z clinical_measurement_ontology CMO:0000236 heart wall thickness The depth of the wall of the aorta, the main trunk from which the arterial system proceeds. mshimoyama 2010-06-17T10:54:17Z aortic wall thickness clinical_measurement_ontology CMO:0000237 aorta wall thickness The thickness or depth of the dorsal/posterior wall of the heart. The dorsal wall is the portion of the heart muscle which is closest to the spine and farthest from the chest wall of the organism. mshimoyama 2010-06-17T11:13:15Z VT:0007087 clinical_measurement_ontology heart dorsal wall thickness CMO:0000238 heart posterior wall thickness The thickness or depth (i.e. the measurement of the two-dimensional extent of the distance between the inner and outer surfaces) of the dorsal/posterior wall of the left ventricle of the heart. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body. mshimoyama 2010-06-17T11:15:28Z VT:0007087 clinical_measurement_ontology heart left ventricle dorsal wall thickness CMO:0000239 Note that "left" in this context refers to the perspective of the organism, not that of the observer. heart left ventricle posterior wall thickness The thickness or depth of the dorsal/posterior wall of the right ventricle of the heart. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism. mshimoyama 2010-06-17T11:15:42Z clinical_measurement_ontology heart right ventricle dorsal wall thickness CMO:0000240 heart right ventricle posterior wall thickness Distance completely around the body in the area between the thorax and hips. In humans, this is commonly at the umbilicus. mshimoyama 2010-06-17T11:28:45Z EFO:0004342 clinical_measurement_ontology waist girth CMO:0000242 waist circumference Any measurement of urine, the fluid waste product excreted by the kidneys, or its components. mshimoyama 2010-06-17T12:26:05Z clinical_measurement_ontology CMO:0000256 urine measurement This calculated measurement is the ratio of the density of urine to the density of water at a given temperature and pressure. mshimoyama 2010-06-17T12:27:01Z VT:0002987 clinical_measurement_ontology urine density CMO:0000257 urine specific gravity The magnitude of the P wave, the initial deflection of the cardiac cycle representing excitation of the atria as presented in an electrocardiogram. mshimoyama 2010-06-17T12:38:44Z clinical_measurement_ontology CMO:0000263 P wave amplitude The time from start to finish of the P wave , in the electrocardiograph illustrating the initial deflection of the cardiac cycle, representing the excitation of the atria. mshimoyama 2010-06-17T12:39:11Z EFO:0005094 clinical_measurement_ontology CMO:0000264 P wave duration The distance to the lowest part of the Q wave which shows the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by electrocardiograph. mshimoyama 2010-06-17T12:39:35Z clinical_measurement_ontology CMO:0000265 Q wave depth The time from start to finish of the Q wave which illustrates the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by an electrocardiograph. mshimoyama 2010-06-17T12:39:55Z clinical_measurement_ontology CMO:0000266 Q wave duration The time from start to finish of the QRS interval as calculated from a set of measurements taken from the beginning of the QRS complex to the end of the QRS complex representing the time it takes for ventricles to depolarize. mshimoyama 2010-06-17T12:40:13Z EFO:0005055 EFO:0007928 VT:2000017 clinical_measurement_ontology ventricular rate measurement CMO:0000267 QRS duration The magnitude of the portion of the electrocardiograph comprising the Q, R, and S waves which together represent ventricular depolarization. mshimoyama 2010-06-17T12:40:30Z EFO:0007742 clinical_measurement_ontology CMO:0000268 QRS amplitude QT interval corrected for heart rate calculated by the QT interval divided by the square root of the interval from one QRS complex to the onset of the next QRS complex measured in seconds. mshimoyama 2010-06-17T12:40:52Z clinical_measurement_ontology CMO:0000269 QTC interval The magnitude of the R wave, which is the initial upward deflection of the QRS complex following the Q wave representing early depolarization of the ventricles as illustrated by an electrocardiograph. mshimoyama 2010-06-17T12:41:09Z EFO:0007741 clinical_measurement_ontology CMO:0000270 R wave amplitude The time from start to finish of the R wave, the initial upward deflection of the QRS complex following the Q wave which represents early depolarization of the ventricles as illustrated in and electrocardiograph. mshimoyama 2010-06-17T12:41:26Z clinical_measurement_ontology CMO:0000271 R wave duration The magnitude of the S wave, the downward deflection of the QRS complex following the R wave representing late depolarization of the ventricles as illustrated in an electrocardiograph. mshimoyama 2010-06-17T12:41:54Z EFO:0007740 clinical_measurement_ontology CMO:0000272 S wave amplitude The time from start to finish of the S wave which is the downward deflection of the QRS complex following the R wave representing late depolarization as illustrated by an electrocardiograph. mshimoyama 2010-06-17T12:42:07Z clinical_measurement_ontology CMO:0000273 S wave duration mshimoyama 2010-06-17T12:42:27Z clinical_measurement_ontology CMO:0000274 ST amplitude mshimoyama 2010-06-17T12:42:46Z clinical_measurement_ontology CMO:0000275 ST slope mshimoyama 2010-06-17T12:43:04Z clinical_measurement_ontology CMO:0000276 ST wave displacement The magnitude of the T wave, the deflection following the QRS complex representing repolarization of the ventricles as illustrated by and electrocardiograph. mshimoyama 2010-06-17T12:43:21Z EFO:0008398 T wave morphology measurement clinical_measurement_ontology CMO:0000277 T wave amplitude An interval measured from the onset of the P wave in one PQRST wave complex to the onset of the P wave in the following PQRST wave complex. mshimoyama 2010-06-17T03:09:47Z EFO:0600085 clinical_measurement_ontology PP_Interval CMO:0000278 PP interval The difference between systolic and diastolic blood pressures, i.e. the difference between the maximal arterial pressure and minimal arterial pressure during the cardiac cycle. mshimoyama 2010-06-25T01:54:10Z EFO:0005763 VT:2000000 pulse pressure measurement clinical_measurement_ontology CMO:0000292 pulse pressure The count of the rhythmic contractions and expansions of an artery due to the surge of blood from the beat of the heart. mshimoyama 2010-08-04T10:37:40Z clinical_measurement_ontology CMO:0000294 pulse The total amount of body fat calculated as fat mass index equal to fat weight divided by height squared. mshimoyama 2010-08-05T09:10:41Z clinical_measurement_ontology CMO:0000304 fat mass index (FMI) mshimoyama 2010-08-05T09:19:24Z EFO:0005409 fat body mass clinical_measurement_ontology total body fat weight CMO:0000305 total body fat mass Portion of the body not comprised of lipids often calculated as fat free mass equal to fat free mass divided by height squared. mshimoyama 2010-08-05T09:21:40Z clinical_measurement_ontology CMO:0000306 fat free mass index (FFMI) Measurement of the physical form or structure of either the right or the left upper chamber of the heart that receives blood from the veins and forces it into a ventricle. mshimoyama 2010-09-01T08:30:15Z clinical_measurement_ontology CMO:0000334 heart atrium morphological measurement The weight of the left atrium of the heart, the upper chamber on the left which empties into the lower chamber. Weight is the heaviness or degree to which a body is drawn toward the earth by gravity. mshimoyama 2010-09-01T08:30:28Z VT:0007026 clinical_measurement_ontology CMO:0000335 left atrium weight The weight of the right atrium, the upper right chamber of the heart which empties into the lower right chamber, i.e. the right ventricle. Weight is the heaviness or degree to which a body is drawn to the earth by gravity. mshimoyama 2010-09-01T08:30:45Z VT:0007027 clinical_measurement_ontology CMO:0000336 right atrium weight A measure of the capacity of the left heart atrium, the upper left chamber which empties into the lower heart chamber. mshimoyama 2010-09-01T08:30:56Z EFO:0600035 left atrial volume measurement clinical_measurement_ontology CMO:0000337 left atrium volume A measure of the three dimensional capacity of the right atrium of the heart, the upper right chamber which empties into the lower right chamber, i.e. the right ventricle. mshimoyama 2010-09-01T08:31:06Z clinical_measurement_ontology CMO:0000338 right atrium volume Any measurement of the physical form or structure of one or both ventricles of the heart, that is, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body. mshimoyama 2010-09-01T08:31:46Z clinical_measurement_ontology CMO:0000339 heart ventricle morphological measurement A calculated measurement in which the weight after removal from the body but without desiccation of both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a ratio, percentage, fraction or quotient, thus normalizing it to body weight. mshimoyama 2011-09-21T01:41:55Z CMO:0000140 VT:0002707 both kidneys wet weight as percentage of body weight clinical_measurement_ontology CMO:0000340 both kidneys wet weight to body weight ratio The amount of triglycerides in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Triglycerides are any of a group of lipids that are esters formed from one molecule of glycerol and three molecules of one or more fatty acids, are widespread in adipose tissue, and commonly circulate in the blood in the form of lipoproteins. mshimoyama 2010-11-12T09:44:31Z VT:0002644 clinical_measurement_ontology CMO:0000360 serum triglyceride level Measurement of the entire amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, without taking into account any association with other molecules such as lipoproteins, in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. mshimoyama 2010-11-12T09:46:59Z VT:0000180 clinical_measurement_ontology serum TC level CMO:0000363 serum total cholesterol level The number of each type of leukocyte present in a specific volume of blood, usually 1 cubic millimeter. mshimoyama 2010-12-13T10:24:28Z VT:0000217 blood differential leukocyte count clinical_measurement_ontology blood differential WBC count CMO:0000366 blood differential white blood cell count A calculated measurement in which the number of all granulocytes (regardless of type) in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage. mshimoyama 2010-12-13T10:35:10Z VT:0000334 clinical_measurement_ontology granulocyte count as percentage of total white blood cells granulocyte count to total WBC count ratio granulocyte count to total white blood cell count ratio granulocyte percentage CMO:0000367 blood granulocyte count to total leukocyte count ratio A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. An eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes. mshimoyama 2010-12-13T10:38:12Z EFO:0007991 VT:0002602 eosinophil percentage of leukocytes clinical_measurement_ontology eosinophil count as percentage of total white blood cells eosinophil count to total WBC count ratio eosinophil granulocyte percentage eosinophil percentage CMO:0000369 blood eosinophil count to total leukocyte count ratio A calculated measurement in which the number of neutrophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes. mshimoyama 2010-12-13T10:39:37Z EFO:0007990 neutrophil granulocyte percentage neutrophil percentage of leukocytes clinical_measurement_ontology neutrophil count as percentage of total white blood cells neutrophil count to total WBC count ratio neutrophil percentage polymorphonuclear cell percentage CMO:0000370 blood neutrophil count to total leukocyte count ratio A calculated measurement in which the number of lymphocytes in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage. mshimoyama 2010-12-13T10:45:39Z EFO:0007993 VT:0000717 lymphocyte percentage of leukocytes clinical_measurement_ontology lymphocyte count as percentage of total white blood cells lymphocyte count to total WBC count ratio lymphocyte percentage CMO:0000371 blood lymphocyte count to total leukocyte count ratio The complete or entire amount of bilirubin in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Bilirubin is the bile pigment produced by breakdown of heme and reduction of biliverdin. mshimoyama 2010-12-13T11:30:05Z EFO:0004570 VT:0001569 bilirubin measurement clinical_measurement_ontology CMO:0000376 serum total bilirubin level Measurement of the physical form or structure of the bony framework of the body or a portion of this framework. mshimoyama 2010-12-29T02:07:26Z clinical_measurement_ontology skeletal morphological measurement CMO:0000437 skeleton morphological measurement Measure of the physical form or structure of one or more bones the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts. mshimoyama 2010-12-29T02:20:55Z clinical_measurement_ontology CMO:0000443 bone morphological measurement Measurement of the linear distance from one end to the other of the tibia, the medial and larger of the two bones of the lower leg of bipeds or hindlimb of quadrupeds which articulates with the femur, fibula, and talus. mshimoyama 2010-12-29T02:36:27Z MA:0001361 VT:0004357 clinical_measurement_ontology CMO:0000450 tibia length The amount of carbonic acid dissolved in carbon dioxide and carbonate ion found in a specified volume of serum. mshimoyama 2011-01-04T12:01:33Z VT:0003015 clinical_measurement_ontology CMO:0000488 serum bicarbonate level The amount of chloride ions found in a specified volume of serum. mshimoyama 2011-01-04T12:06:48Z VT:0003018 clinical_measurement_ontology CMO:0000489 serum chloride level Glomerular filtration rate describes the flow rate of filtered fluid through the kidney. It is calculated by comparative measurements of substances (ex. creatinine or inulin) in the blood and urine over a designated period of time. mshimoyama 2011-01-04T02:41:58Z EFO:0005208 VT:0002847 Calculated GFR cGFR eGFR estimated glomerular filtration rate clinical_measurement_ontology CMO:0000490 glomerular filtration rate mshimoyama 2011-01-04T02:48:14Z clinical_measurement_ontology CMO:0000491 blood glomerular filtration rate, Diet in Renal Disease Formula (MDRD) A calculated measurement which estimates the glomerular filtration rate (GFR), that is, the volume of fluid filtered from the renal capillaries per unit time, based on the serum creatinine level and adjusted for gender. mshimoyama 2011-01-04T02:48:55Z clinical_measurement_ontology CMO:0000492 blood glomerular filtration rate, Chronic Kidney Disease Epidemiology Collaboration formula (CKE-EPI) mshimoyama 2011-01-04T02:50:15Z clinical_measurement_ontology CMO:0000493 blood glomerular filtration rate, May Quadratic formula mshimoyama 2011-01-04T02:50:43Z clinical_measurement_ontology CMO:0000494 blood glomerular filtration rate, Schwartz formula Amount of potassium ions in a specified volume of serum. mshimoyama 2011-01-04T02:52:02Z VT:0002668 clinical_measurement_ontology CMO:0000495 serum potassium level The amount of potassium ions in a specified volume of blood. mshimoyama 2011-01-04T02:53:16Z potassium measurement EFO:0009283 VT:0002668 clinical_measurement_ontology CMO:0000496 blood potassium level mshimoyama 2011-01-04T02:54:42Z VT:0003015 clinical_measurement_ontology CMO:0000498 blood bicarbonate level The amount of sodium ions in a specified volume of blood. mshimoyama 2011-01-04T02:55:51Z sodium measurement EFO:0009282 VT:0001776 clinical_measurement_ontology CMO:0000499 blood sodium level The amount of sodium ions in a specified volume of serum. mshimoyama 2011-01-04T02:56:30Z VT:0001776 clinical_measurement_ontology CMO:0000500 serum sodium level The amount of calcium ions in a specified volume of serum. mshimoyama 2011-01-04T03:15:06Z VT:0001562 clinical_measurement_ontology CMO:0000503 serum calcium level Blood pressure measured in the pulmonary artery during diastole, that is, during dilation or relaxation of the heart ventricles. mshimoyama 2011-01-21T08:57:36Z clinical_measurement_ontology CMO:0000528 pulmonary arterial diastolic blood pressure Blood pressure measured in the pulmonary artery during systole, that is, during contraction of the heart ventricles. mshimoyama 2011-01-21T08:58:00Z clinical_measurement_ontology CMO:0000529 pulmonary arterial systolic blood pressure A calculated value in which the weight of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, is divided by the total weight of the body and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and by extension to the size of the organism. mshimoyama 2011-01-21T09:42:17Z CMO:0000540 EFO:0009290 PMID:24205240 VT:0007031 LV mass index LV mass/BW LVMI left ventricular mass index heart left ventricle weight as a percentage of body weight clinical_measurement_ontology CMO:0000530 heart left ventricle weight to body weight ratio The difference in mean arterial blood pressure between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. mshimoyama 2011-10-28T04:24:16Z VT:2000000 clinical_measurement_ontology CMO:0000533 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in mean arterial blood pressure Absolute difference in heart rate between two points in time or two conditions. mshimoyama 2011-10-28T04:25:37Z VT:2000009 clinical_measurement_ontology CMO:0000534 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in heart rate The number of glomeruli in all or part of a kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation. mshimoyama 2011-10-28T04:29:17Z VT:0010544 glomeruli count glomeruli number glomerulus number clinical_measurement_ontology CMO:0000536 kidney glomerulus count mshimoyama 2011-10-28T04:33:14Z clinical_measurement_ontology CMO:0000539 heart left ventricle dry weight The amount of phosphorus, measured as inorganic phosphate, in a specified sample of serum. mshimoyama 2011-11-02T02:44:01Z VT:0001565 clinical_measurement_ontology serum inorganic phosphate level serum inorganic phosphorus level serum phosphorus level CMO:0000542 serum phosphate level Measurement of the amount of glucose, the monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues which is one of the three dietary monosaccharides that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms, in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. mshimoyama 2011-11-02T02:45:05Z VT:0000188 clinical_measurement_ontology CMO:0000543 serum glucose level The amount of albumin in a specified sample of blood. Albumin is the major plasma protein, responsible for much of the plasma colloidal osmotic pressure and serving as a transport protein for large organic anions (e.g., fatty acids, bilirubin, some drugs) and for some hormones when their specific binding globulins are saturated. mshimoyama 2011-11-02T02:47:55Z VT:0000199 clinical_measurement_ontology CMO:0000549 blood albumin level The amount of albumin in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. mshimoyama 2011-11-02T02:48:13Z EFO:0004535 VT:0000199 serum albumin measurement clinical_measurement_ontology CMO:0000550 serum albumin level The amount of enzymatic activity of glutamic-pyruvate transaminase enzyme, commonly known as alanine transaminase or alanine aminotransferase (ALT), enzyme in a specified sample of blood. ALT catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Blood ALT level is used as an enzymatic marker for liver disease or damage. mshimoyama 2011-11-02T04:09:38Z VT:0001573 blood ALT activity level blood GPT activity level blood alanine transaminase activity level blood glutamic-pyruvate transaminase activity level clinical_measurement_ontology CMO:0000574 blood alanine aminotransferase activity level The amount of ezymatic activity of glutamic-pyruvate transaminase enzyme, commonly known as alanine transaminase or alanine aminotransferase (ALT), enzyme in a specified sample of serum. ALT catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Serum ALT level is used as an enzymatic marker for liver disease or damage. mshimoyama 2011-11-02T04:10:11Z EFO:0004735 VT:0001573 serum ALT activity level serum GPT activity level serum alanine aminotransferase measurement serum alanine transaminase activity level serum glutamic-pyruvate transaminase activity level clinical_measurement_ontology CMO:0000575 serum alanine aminotransferase activity level Quantitation of the catalytic effect exerted by alkaline phosphatase (AP) in a specified sample of blood. AP is an enzyme that catalyzes the cleavage of orthophosphate from orthophosphoric monoesters under alkaline conditions. mshimoyama 2011-11-02T04:10:38Z EFO:0004533 VT:0000202 alkaline phosphatase measurement clinical_measurement_ontology CMO:0000576 blood alkaline phosphatase activity level Quantitation of the catalytic effect exerted by alkaline phosphatase (AP) in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. AP is an enzyme that catalyzes the cleavage of orthophosphate from orthophosphoric monoesters under alkaline conditions. mshimoyama 2011-11-02T04:11:05Z VT:0000202 clinical_measurement_ontology CMO:0000577 serum alkaline phosphatase activity level The amount of enzymatic activity of glutamic-oxaloacetic transaminase enzyme, commonly known as aspartate transaminase or aspartate aminotransferase (AST), in a specified sample of blood. AST catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid. Blood AST level is used as an enzymatic marker for liver disease or damage. mshimoyama 2011-11-02T04:17:35Z aspartate aminotransferase measurement EFO:0004736 EFO:0008031 VT:0000203 aspartate aminotransferase, cytoplasmic measurement blood aspartate transaminase activity level blood glutamic-oxaloacetic transaminase activity level clinical_measurement_ontology blood AST activity level blood GOT activity level CMO:0000580 blood aspartate aminotransferase activity level The amount of enzymatic activity of glutamic-oxaloacetic transaminase enzyme, commonly known as aspartate transaminase or aspartate aminotransferase (AST), in a specified sample of serum. AST catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid. Serum AST level is used as an enzymatic marker for liver disease or damage. mshimoyama 2011-11-02T04:18:08Z VT:0000203 serum aspartate transaminase activity level serum glutamic-oxaloacetic transaminase activity level clinical_measurement_ontology SGOT activity level serum AST activity level serum GOT activity level CMO:0000581 serum aspartate aminotransferase activity level mshimoyama 2011-11-03T01:45:21Z VT:0005160 clinical_measurement_ontology CMO:0000591 urine protein level Measurement of the pressure within the heart left ventricle at the end of systole, the period of contraction of the heart when the blood is forced from the ventricles into the pulmonary artery (right ventricle) and the aorta (left ventricle). mshimoyama 2011-11-03T02:34:53Z PMID:32207065 VT:0010750 PES end-systolic blood pressure clinical_measurement_ontology CMO:0000605 left ventricular end-systolic blood pressure The pressure in the heart left ventricle at the end of diastole, the period when the heart is in a state of relaxation and expansion and the ventricles fill with blood. mshimoyama 2011-11-03T02:35:59Z VT:0010750 LVEDP left ventricular end-diastolic pressure clinical_measurement_ontology CMO:0000606 left ventricular end-diastolic blood pressure Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity. mshimoyama 2011-11-03T02:36:40Z VT:2000000 clinical_measurement_ontology CMO:0000607 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in systolic blood pressure Calculated measurement of a difference in diastolic blood pressure between two points or two conditions expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood. mshimoyama 2011-11-03T02:36:56Z clinical_measurement_ontology CMO:0000608 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in diastolic blood pressure A calculated measurement in which the weight after removal from the body but without desiccation of a single kidney, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a ratio, percentage, fraction or quotient, thus normalizing it to body weight. mshimoyama 2011-11-03T02:50:38Z CMO:0000623 VT:0002707 individual kidney wet weight as percentage of body weight individual kidney wet weight to body weight ratio single kidney wet weight as percentage of body weight clinical_measurement_ontology CMO:0000622 single kidney wet weight to body weight ratio Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in very low-density lipoprotein (VLDL) molecules in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. VLDL constitute a class of large (e.g. approximately 30-80 nm in diameter) lipoprotein particles, complex molecules that consist of a protein membrane surrounding a core of lipids. The VLDL class of lipoproteins has a density between 0.95 and 1.006 g/ml. mshimoyama 2011-11-03T03:16:59Z very low density lipoprotein cholesterol measurement EFO:0008317 VT:0005144 clinical_measurement_ontology blood VLDL level blood VLDL-C level CMO:0000648 Values for density ranges of the lipoprotein classes are approximate. The classes may be defined differently by different researchers, in part because class definitions depend on the number of subclasses into which the lipoprotein fractions are divided. blood very low density lipoprotein cholesterol level mshimoyama 2011-11-04T12:57:25Z clinical_measurement_ontology CMO:0000656 heart right ventricle dry weight Any measurement of components of the periodic tightening and loosening of the heart muscle. jsmith 2012-02-15T11:39:00Z clinical_measurement_ontology heart contractility measurement CMO:0000662 heart contraction measurement Measure of the time from the relaxation of the heart muscle to the beginning of the tightening of the heart muscle during contraction. jsmith 2012-02-15T11:42:05Z VT:2000009 clinical_measurement_ontology CMO:0000663 time to onset of heart contraction Measurement of the time from the beginning of heart muscle contraction to the maximum contracted state. jsmith 2012-02-15T11:48:18Z VT:2000009 clinical_measurement_ontology CMO:0000664 time to peak heart contraction Pressure exerted by the heart muscle in its maximally contracted state. jsmith 2012-02-15T11:56:51Z VT:2000018 clinical_measurement_ontology CMO:0000665 heart contraction pressure Any measurement of a structural part of a system of the body that is composed of tissues and cells that enable it to perform a particular function. jsmith 2012-02-15T05:00:53Z clinical_measurement_ontology CMO:0000669 organ measurement jsmith 2012-02-15T05:06:19Z clinical_measurement_ontology CMO:0000670 This is not the same term as the original "heart measurement". That term is now "heart morphological measurement". heart measurement A measurement made on a fluid flowing out of the heart. jsmith 2012-02-15T05:11:39Z clinical_measurement_ontology CMO:0000671 heart effluent measurement The volume of a fluid flowing out of the heart. jsmith 2012-02-15T05:14:44Z clinical_measurement_ontology CMO:0000672 heart effluent volume The volume of a fluid flowing out of the heart during a specified amount of time. jsmith 2012-02-15T05:16:22Z clinical_measurement_ontology CMO:0000673 timed heart effluent volume The amount of an enzyme in a specified volume of fluid flowing out of the heart. jsmith 2012-02-15T05:21:20Z clinical_measurement_ontology CMO:0000675 heart effluent enzyme level The amount of lactate dehydrogenase activity measured in a specified volume of fluid flowing out of the heart. jsmith 2012-02-15T05:25:02Z heart effluent LDH activity level clinical_measurement_ontology CMO:0000676 heart effluent lactate dehydrogenase activity level Measurement of a lesion in an organ. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-02-15T05:45:18Z clinical_measurement_ontology tissue damage measurement CMO:0000677 organ lesion measurement A measurement of any lesion of the heart. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-02-15T05:48:03Z clinical_measurement_ontology CMO:0000678 heart lesion measurement Measurement of an area of necrotic tissue resulting from a reduction or obstruction of the oxygen supplied to that tissue. jsmith 2012-02-15T05:50:09Z clinical_measurement_ontology CMO:0000679 infarction measurement Measurement of an area of necrotic tissue in the heart resulting from a reduction or obstruction of the oxygen supply. jsmith 2012-02-15T05:58:36Z clinical_measurement_ontology myocardial infarction measurement CMO:0000680 heart infarction measurement Measurement of an area of necrotic tissue in the left ventricle of the heart resulting from a reduction or obstruction of the oxygen supply to the heart. jsmith 2012-02-15T06:09:00Z clinical_measurement_ontology CMO:0000682 heart left ventricle infarction measurement Measurement of the area, volume or weight of necrotic tissue resulting from a reduction or obstruction of the oxygen supplied to that tissue. jsmith 2012-02-15T06:11:07Z clinical_measurement_ontology CMO:0000683 organ infarction size measurement Measurement of the area, volume or weight of necrotic tissue in the heart resulting from a reduction or obstruction of the oxygen supply to the heart. jsmith 2012-02-15T06:14:35Z clinical_measurement_ontology CMO:0000684 heart infarction size Measurement of the area, volume or weight of necrotic tissue in the heart left ventricle resulting from a reduction or obstruction of the oxygen supply to the heart. jsmith 2012-02-15T06:18:51Z clinical_measurement_ontology CMO:0000685 heart left ventricle infarction size The heaviness of one or both ventricles of the heart, that is, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body, or the degree to which one or both ventricles of the heart are drawn toward the earth by gravity. jsmith 2012-02-15T06:46:40Z clinical_measurement_ontology CMO:0000688 heart ventricle weight jsmith 2012-02-21T02:50:48Z clinical_measurement_ontology CMO:0000689 heart infarction weight jsmith 2012-02-21T03:02:09Z clinical_measurement_ontology CMO:0000690 heart infarction area jsmith 2012-02-21T03:02:46Z clinical_measurement_ontology CMO:0000691 heart left ventricle infarction weight jsmith 2012-02-21T03:03:35Z VT:0010745 clinical_measurement_ontology CMO:0000692 heart left ventricle infarction area jsmith 2012-02-21T03:04:15Z VT:0010745 clinical_measurement_ontology CMO:0000693 calculated heart left ventricle infarction area jsmith 2012-02-21T03:04:51Z clinical_measurement_ontology CMO:0000694 calculated heart left ventricle infarction weight jsmith 2012-02-21T03:05:44Z VT:0010745 clinical_measurement_ontology CMO:0000695 heart left ventricle infarction weight to total heart left ventricle weight ratio jsmith 2012-02-21T03:08:57Z clinical_measurement_ontology CMO:0000696 calculated heart infarction weight The difference in body temperature between two different points in time or between two different conditions. jsmith 2012-03-09T04:05:52Z VT:0005535 clinical_measurement_ontology CMO:0000699 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in body temperature Measurement of the amount of resistance in a blood vessel to the flow of blood or other fluid through it. jsmith 2012-03-09T05:24:30Z clinical_measurement_ontology CMO:0000700 blood vessel resistance measurement Resistance to blood flow by blood vessels in the lung. jsmith 2012-03-09T05:53:03Z clinical_measurement_ontology CMO:0000701 pulmonary vascular resistance (PVR) Measurement of vascular resistance in lung blood vessels calculated from other indirect measurements. jsmith 2012-03-09T05:57:02Z calculated PVR clinical_measurement_ontology CMO:0000702 calculated pulmonary vascular resistance jsmith 2012-03-09T06:00:03Z VT:0002295 R_Flow100 clinical_measurement_ontology CMO:0000703 calculated pulmonary vascular resistance normalized to body weight Measurement made on the endothelial tissue or endothelial cells lining a blood vessel. jsmith 2012-03-13T12:26:02Z clinical_measurement_ontology CMO:0000706 blood vessel endothelium measurement jsmith 2012-03-13T12:29:04Z clinical_measurement_ontology CMO:0000707 calculated blood vessel endothelium measurement jsmith 2012-03-13T12:31:07Z VT:0002295 clinical_measurement_ontology CMO:0000708 FAPGG metabolism-surface area product jsmith 2012-03-13T01:02:07Z VT:0002295 clinical_measurement_ontology CMO:0000709 methylene blue metabolism-surface area product without auto-oxidation jsmith 2012-03-13T01:03:47Z VT:0002295 clinical_measurement_ontology CMO:0000710 methylene blue metabolism-surface area product after auto-oxidation Ratio of the methylene blue metabolism-surface area product without auto-oxidation to the FAPGG metabolism-surface area product. jsmith 2012-03-13T01:12:29Z VT:0002295 clinical_measurement_ontology CMO:0000711 methylene blue to FAPGG metabolism-surface area product ratio Any measurement of the energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel. jsmith 2012-03-13T04:15:39Z VT:0000198 clinical_measurement_ontology blood vessel contractility measurement CMO:0000716 blood vessel contractile force measurement Measurement of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel. jsmith 2012-03-13T04:46:14Z clinical_measurement_ontology blood vessel maximum contractility measurement CMO:0000717 blood vessel maximum contractile force jsmith 2012-03-13T04:47:52Z clinical_measurement_ontology CMO:0000718 maximum contractile force per wet weight of vessel Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to a drug or other chemical stimulus. jsmith 2012-03-14T04:09:34Z clinical_measurement_ontology CMO:0000719 chemical response/sensitivity measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel. jsmith 2012-03-14T04:16:11Z clinical_measurement_ontology CMO:0000720 calculated blood vessel contractile force measurement A calculated value for the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy. jsmith 2012-03-14T04:17:28Z CHEBI:8093 VT:0000198 phenylephrine half maximal effective concentration (EC50) clinical_measurement_ontology CMO:0000721 concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) A calculated value for logarithm of the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. jsmith 2012-03-14T04:17:54Z CHEBI:8093 VT:0000198 phenylephrine Log half maximal effective concentration (Log EC50) clinical_measurement_ontology CMO:0000722 logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Measurement of the reduction in force during dilation of a blood vessel via calculations from direct measurements rather than expressing the direct measurements themselves. jsmith 2012-03-14T04:21:12Z clinical_measurement_ontology CMO:0000723 calculated blood vessel dilation force reduction measurement A calculated value for the concentration of acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of ACh is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during ACh-induced relaxation of the vessel wall (i.e. the maximum effect of Ach which is the minimum contractile energy). jsmith 2012-03-14T04:23:57Z CHEBI:15355 VT:0000197 acetylcholine half maximal effective concentration (EC50) clinical_measurement_ontology CMO:0000724 concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) A calculated value for logarithm of the concentration of acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter, at which the dilation of a blood vessel in response to the application of ACh is half maximal. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. jsmith 2012-03-14T04:24:16Z CHEBI:15355 VT:0005594 acetylcholine Log half maximal effective concentration (Log EC50) clinical_measurement_ontology CMO:0000725 logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) A calculated value for the concentration of sodium nitroprusside (SNP), the red-colored inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of SNP is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during SNP-induced relaxation of the vessel wall (i.e. the maximum effect of SNP which is the minimum contractile energy). jsmith 2012-03-14T04:24:44Z CHEBI:29321 CHEBI:9179 VT:0000197 sodium nitroprusside half maximal effective concentration (EC50) clinical_measurement_ontology CMO:0000726 concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) A calculated value for logarithm of the concentration of sodium nitroprusside (SNP), the red-coloured inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of SNP is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during SNP-induced relaxation of the vessel wall (i.e. the maximum effect of SNP which is the minimum contractile energy). jsmith 2012-03-14T04:25:16Z CHEBI:29321 CHEBI:9179 VT:0005594 sodium nitroprusside Log half maximal effective concentration (Log EC50) clinical_measurement_ontology CMO:0000727 logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) jsmith 2012-03-15T11:42:31Z VT:0000198 clinical_measurement_ontology CMO:0000728 maximum contractile force per wet weight of aorta Measurement of the reduction in force during blood vessel dilation. jsmith 2012-03-15T11:48:29Z clinical_measurement_ontology CMO:0000729 blood vessel dilation force reduction measurement This is a measure of the relaxation caused by the addition of some agent or process to a pre-constricted blood vessel. It is the ratio of the amount of dilation generated compared to a fully dilated blood vessel. jsmith 2012-03-15T11:53:37Z PMID:11748519 blood vessel dilation expressed as percent relaxation of the force generated in a pre-constricted blood vessel clinical_measurement_ontology CMO:0000730 blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel This is a measure of the relaxation caused by the addition of acetylcholine to a pre-constricted blood vessel. It is the ratio of the amount of dilation compared to a fully dilated blood vessel. jsmith 2012-03-15T11:55:20Z PMID:11748519 PMID:17906683 VT:0000197 acetylcholine-induced blood vessel relaxation expressed as percent of full dilation clinical_measurement_ontology CMO:0000731 acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel This is a measure of the relaxation caused by the addition of sodium nitroprusside to a pre-constricted blood vessel. It is the ratio of the amount of dilation compared to a fully dilated blood vessel. jsmith 2012-03-15T11:59:59Z PMID:11748519 VT:0000197 sodium nitroprusside-induced blood vessel relaxation expressed as percent of full dilation clinical_measurement_ontology CMO:0000732 sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel This is a measure of the relaxation caused by hypoxia on a pre-constricted blood vessel. It is the ratio of the amount of dilation compared to a fully dilated blood vessel. jsmith 2012-03-15T12:00:51Z PMID:11748519 VT:0000197 clinical_measurement_ontology CMO:0000733 hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel jsmith 2012-03-15T12:03:40Z slope measurement of phenylephrine-induced contraction clinical_measurement_ontology slope measurement of drug-induced contraction CMO:0000734 slope measurement of chemical-induced contraction jsmith 2012-03-15T12:05:49Z fast-slope measurement of phenylephrine-induced contraction clinical_measurement_ontology fast-slope measurement of drug-induced contraction CMO:0000735 fast-slope measurement of chemical-induced contraction jsmith 2012-03-15T12:06:21Z slow-slope measurement of phenylephrine-induced contraction clinical_measurement_ontology slow-slope measurement of drug-induced contraction CMO:0000736 slow-slope measurement of chemical-induced contraction Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter. jsmith 2012-03-15T12:11:24Z CHEBI:15355 clinical_measurement_ontology CMO:0000737 acetylcholine response/sensitivity measurement Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor. jsmith 2012-03-15T12:12:47Z CHEBI:8093 clinical_measurement_ontology CMO:0000739 phenylephrine response/sensitivity measurement Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to sodium nitroprusside (SNP), the red-colored inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator. jsmith 2012-03-15T12:13:21Z CHEBI:29321 clinical_measurement_ontology CMO:0000740 sodium nitroprusside response/sensitivity measurement jsmith 2012-03-20T04:21:00Z VT:2000009 clinical_measurement_ontology CMO:0000742 percent change in heart rate Calculation of a difference between representations of blood pressure in a treated versus untreated state or over time, after the original values have been normalized or adjusted by a mathematical process or computation. Blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood. jsmith 2012-03-20T04:31:30Z EFO:0006943 blood pressure change measurement clinical_measurement_ontology CMO:0000743 change in calculated blood pressure A calculated measurement of the difference in developed blood pressure between a treated state and a control state. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled. jsmith 2012-03-20T04:31:52Z clinical_measurement_ontology CMO:0000744 change in developed blood pressure A calculated measurement of the difference in developed blood pressure between a treated state and a control state, expressed as a percentage. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled. jsmith 2012-03-20T04:32:19Z clinical_measurement_ontology CMO:0000745 percent change in developed blood pressure Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions. jsmith 2012-03-20T04:34:31Z EFO:0006944 systolic blood pressure change measurement clinical_measurement_ontology CMO:0000746 change in systolic blood pressure The relative difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions expressed as a percentage. jsmith 2012-03-20T04:35:00Z clinical_measurement_ontology CMO:0000747 percent change in systolic blood pressure jsmith 2012-03-20T04:37:30Z clinical_measurement_ontology CMO:0000748 change in arterial blood flow rate jsmith 2012-03-20T04:38:02Z VT:0000261 clinical_measurement_ontology CMO:0000749 percent change in arterial blood flow rate jsmith 2012-03-20T04:38:35Z clinical_measurement_ontology CMO:0000750 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in arterial blood flow rate A calculated measurement of the difference in developed pressure measured in the heart left ventricle between a treated state and a control state, expressed as a percentage. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled. jsmith 2012-03-21T01:08:08Z VT:0010750 clinical_measurement_ontology CMO:0000751 percent change in left ventricular developed pressure A calculated measurement of the difference in developed pressure measured in the heart left ventricle between a treated state and a control state. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled. jsmith 2012-03-21T01:09:30Z clinical_measurement_ontology CMO:0000752 change in left ventricular developed pressure Difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions. jsmith 2012-03-21T01:13:41Z clinical_measurement_ontology CMO:0000753 change in left ventricular systolic blood pressure The relative difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions expressed as a percentage. jsmith 2012-03-21T01:14:31Z clinical_measurement_ontology CMO:0000754 percent change in left ventricular systolic blood pressure jsmith 2012-03-28T11:15:22Z creatinine measurement CHEBI:16737 EFO:0004518 clinical_measurement_ontology CMO:0000767 blood creatinine measurement The activity level of LDH in effluent expressed relative to the weight of the heart; calculated as LDH activity divided by heart wet weight. jsmith 2012-03-30T07:52:39Z VT:0010756 clinical_measurement_ontology CMO:0000775 heart effluent lactate dehydrogenase activity level normalized to heart weight jsmith 2012-06-07T11:37:18Z VT:0007031 clinical_measurement_ontology CMO:0000776 heart left ventricle weight jsmith 2012-06-07T11:38:49Z VT:0007033 clinical_measurement_ontology CMO:0000777 heart right ventricle weight The average blood pressure within the pulmonary artery over a specified period of time, or technically over a complete cycle of one heartbeat. jsmith 2012-06-07T12:01:20Z VT:0010782 clinical_measurement_ontology mean pulmonary artery (PA) pressure CMO:0000778 mean pulmonary arterial blood pressure Measurement of blood pressure in the pulmonary artery. jsmith 2012-06-07T02:24:23Z clinical_measurement_ontology pulmonary artery (PA) blood pressure measurement pulmonary artery pressure CMO:0000782 pulmonary arterial blood pressure measurement This is a measurement of an organ lesion which is a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. jsmith 2012-06-26T11:34:46Z organ tumor measurement clinical_measurement_ontology Not4Curation CMO:0000859 organ tumorous lesion measurement Measurement of an organ lesion which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc. jsmith 2012-06-26T11:46:40Z clinical_measurement_ontology CMO:0000860 organ non-tumorous lesion measurement Measurement of a heart lesion which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc. jsmith 2012-06-26T12:53:39Z clinical_measurement_ontology CMO:0000861 heart non-tumorous lesion measurement Measurement of a lesion of the heart which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells. jsmith 2012-06-26T01:22:44Z clinical_measurement_ontology CMO:0000865 heart tumorous lesion measurement This is any measurement, morphological or physiological, involving the kidney or any part thereof. jsmith 2012-07-11T10:34:14Z clinical_measurement_ontology Not4Curation CMO:0000906 kidney measurement Renal blood flow (RBF) is the volume of blood delivered to or exiting from the kidneys per unit time. jsmith 2012-07-11T10:38:08Z VT:2000006 clinical_measurement_ontology CMO:0000907 renal blood flow rate Arterial renal blood flow (RBFa) is the volume of blood delivered to the kidneys per unit time via the renal arteries. jsmith 2012-07-11T10:44:48Z VT:0000261 clinical_measurement_ontology CMO:0000908 renal arterial blood flow rate Venous renal blood flow (RBFv) is the volume of blood exiting from the kidneys per unit time via the renal veins. jsmith 2012-07-11T10:48:22Z clinical_measurement_ontology CMO:0000909 renal venous blood flow rate Any measurement of all or part of the brain, the portion of the central nervous system enclosed within the cranium which is composed of gray matter and white matter and is the primary center for the regulation and control of bodily activities, receiving and interpreting sensory impulses, and transmitting information to the muscles and body organs. jsmith 2012-07-11T11:08:16Z EFO:0004464 EFO:0007738 MA:0000168 cingulate cortex measurement clinical_measurement_ontology Not4Curation CMO:0000911 brain measurement A calculated value in which the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is divided by the total weight of the body and presented as a ratio thus normalizing it to body weight. jsmith 2012-07-11T12:08:49Z VT:0007033 clinical_measurement_ontology CMO:0000914 heart right ventricle weight to body weight ratio A calculated value in which the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is presented as percentage of the total weight of the body thus normalizing it to body weight. jsmith 2012-07-11T12:09:38Z clinical_measurement_ontology CMO:0000915 heart right ventricle weight as a percentage of body weight Measurement of the bodily system that consists of the muscles, bones, joints, and related structures, such as the tendons and connective tissue and which supports and protects the body, functions in the movement of body parts and organs, produces blood cells, and stores minerals. jsmith 2012-07-12T10:30:15Z clinical_measurement_ontology CMO:0000916 musculoskeletal system measurement Any measurement of the physical form or structure of the left ventricle of the heart. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body. jsmith 2012-07-18T04:24:26Z EFO:0007602 EFO:0008205 left ventricular structural measurement total ventricular volume measurement clinical_measurement_ontology CMO:0000951 Note, "left" in this context refers to the perspective of the organism, not that of the observer. heart left ventricle morphological measurement Any measurement of the physical form or structure of the right ventricle of the heart. The right ventricle is the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung. jsmith 2012-07-18T04:30:51Z clinical_measurement_ontology CMO:0000952 heart right ventricle morphological measurement Measurement of a localized pathological change in structure of a blood vessel due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-07-26T10:04:12Z EFO:0007938 coronary atherosclerosis measurement clinical_measurement_ontology CMO:0000962 blood vessel lesion measurement A measurement of blood vessel diameter which has been normalized or adjusted by a mathematical process or computation. jsmith 2012-07-26T12:15:46Z clinical_measurement_ontology Not4Curation CMO:0000963 calculated blood vessel diameter measurement jsmith 2012-07-26T12:18:48Z clinical_measurement_ontology CMO:0000964 blood vessel wall thickness A measurement of the depth of the wall of a blood vessel which has been normalized or adjusted by a mathematical process or computation. jsmith 2012-07-26T12:20:54Z clinical_measurement_ontology Not4Curation CMO:0000965 calculated blood vessel wall thickness measurement A measurement of the depth of the wall of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. jsmith 2012-07-26T12:23:13Z clinical_measurement_ontology CMO:0000966 artery wall thickness A measurement of the depth of the wall of an artery which has been normalized or adjusted by a mathematical process or computation. An artery is one of the large blood vessels carrying blood in a direction away from the heart to the tissues. jsmith 2012-07-26T12:27:42Z clinical_measurement_ontology Not4Curation CMO:0000967 calculated artery wall thickness measurement jsmith 2012-07-26T12:32:00Z VT:0002191 VT:0010641 clinical_measurement_ontology CMO:0000968 artery diameter The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at the inner surface of the blood vessel wall. jsmith 2012-07-26T12:39:26Z blood vessel lumen diameter clinical_measurement_ontology CMO:0000969 blood vessel inner diameter The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at the outer surface of the blood vessel wall. jsmith 2012-07-26T12:41:25Z clinical_measurement_ontology CMO:0000970 blood vessel outer diameter The length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. jsmith 2012-07-26T12:43:00Z artery lumen diameter clinical_measurement_ontology CMO:0000971 artery inner diameter The length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the outer surface of the blood vessel wall. jsmith 2012-07-26T12:44:18Z artery exyernal diameter clinical_measurement_ontology CMO:0000972 artery outer diameter Measurement of the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at either the inner surface or outer surface of the blood vessel wall, which has been normalized or adjusted by a mathematical process or computation. jsmith 2012-07-26T12:48:55Z clinical_measurement_ontology Not4Curation CMO:0000973 calculated artery diameter measurement Any measurement of one of the large blood vessels carrying blood in a direction away from the heart to the tissues. jsmith 2012-07-26T12:57:08Z clinical_measurement_ontology CMO:0000974 artery measurement Measurement of any localized pathological change in structure of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues, due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-07-26T12:59:52Z clinical_measurement_ontology CMO:0000975 artery lesion measurement Measurement which has been normalized or adjusted by a mathematical process or computation of any localized pathological change in structure of an artery due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-07-26T02:04:57Z clinical_measurement_ontology Not4Curation CMO:0000976 calculated artery lesion measurement Measurement which has been normalized or adjusted by a mathematical process or computation of any localized pathological change in structure of a blood vessel due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-07-26T02:13:01Z clinical_measurement_ontology Not4Curation CMO:0000977 calculated blood vessel lesion measurement A calculated measurement in which the ratio of the wall thickness (WT) of a blood vessel is divided by the inner diameter (ID) of that vessel at that location, and the result presented as a ratio, fraction, quotient or percentage, for example, WT/ID x 100. This measurement is often used to assess stenosis, a pathological narrowing of a blood vessel. jsmith 2012-07-26T02:14:51Z blood vessel wall thickness as percentage of blood vessel lumen diameter clinical_measurement_ontology blood vessel stenosis measurement blood vessel wall thickness as percentage of blood vessel inner diameter CMO:0000978 blood vessel wall thickness to blood vessel inner diameter ratio Ratio of the wall thickness (WT) of an artery to inner diameter (ID) of that artery at that location, usually expressed as a percentage, i.e. WT/ID x 100, but could also be expressed as a ratio, fraction or quotient. This measurement can be used to assess stenosis, a pathological narrowing of a blood vessel. jsmith 2012-07-26T02:16:51Z VT:0002191 VT:0010786 clinical_measurement_ontology arterial stenosis measurement artery wall thickness as percentage of artery inner diameter artery wall thickness as percentage of artery lumen diameter CMO:0000979 artery wall thickness to artery inner diameter ratio A measurement of the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall, after that measurement has been normalized or adjusted by a mathematical process or computation. An artery is a blood vessel that carries blood away from the heart. jsmith 2012-07-26T02:25:16Z clinical_measurement_ontology Not4Curation CMO:0000980 calculated artery inner diameter measurement Any measurement of components of the periodic tightening and loosening of the muscles of a ventricle of the heart. jsmith 2012-07-26T03:24:53Z clinical_measurement_ontology CMO:0000981 ventricle contraction measurement The diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter. jsmith 2012-07-27T03:14:05Z VT:0010758 LVEDD heart left ventricular end-diastolic diameter left ventricular end-diastolic dimension clinical_measurement_ontology LVDD CMO:0000982 heart left ventricle end-diastolic diameter The diameter across the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter. jsmith 2012-07-27T03:32:16Z VT:0010759 clinical_measurement_ontology LVESD LVSD left ventricular end-systolic dimension CMO:0000983 heart left ventricle end-systolic diameter A measurement of the physical form or structure of the left ventricle of the heart which has been normalized or adjusted by a mathematical process or computation. The heart left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body. jsmith 2012-07-27T03:42:40Z clinical_measurement_ontology CMO:0000984 calculated heart left ventricle morphological measurement A calculated measurement corresponding to the ratio or percent reduction in left ventricular diameter between end-diastole and end-systole. Can be calculated as the left ventricle end-diastolic diameter (LVDd) minus the left ventricle end-systolic diameter (LVSd) divided by the left ventricle end-diastolic diameter (LVDd) with the quotient multiplied by 100, i.e. FS = [(LVDd-LVSd)/LVDd] x 100. jsmith 2012-07-27T03:51:33Z fractional shortening EFO:0009285 VT:0010758 clinical_measurement_ontology CMO:0000985 heart left ventricle fractional shortening The thickness or depth of the ventral/anterior wall of the left ventricle of the heart. The ventral/anterior wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism. jsmith 2012-07-27T04:11:09Z VT:0010491 clinical_measurement_ontology heart left ventricle ventral wall thickness CMO:0000986 heart left ventricle anterior wall thickness The thickness or depth of the septal wall of the heart ventricles. The septal wall is the portion of the heart left ventricle ventral/anterior wall and right ventricle dorsal/posterior wall which is shared between the ventricles. jsmith 2012-07-27T05:59:34Z VT:0007086 clinical_measurement_ontology SWT antero-septal wall thickness heart interventricular septum thickness heart intraventricular wall thickness heart ventricle septum thickness heart ventricular septal wall thickness CMO:0000987 heart ventricle septal wall thickness A calculated measurement of left ventricular geometry. It is calculated by dividing the end-diastolic diameter into 2x the posterior wall thickness or into the sum of the posterior and septal wall thicknesses. It represents a measure of the wall thickness normalized to the size of the ventricle lumen. jsmith 2012-07-27T06:00:34Z CMO:0000989 VT:0007075 RWT heart left ventricle end-diastolic relative wall thickness clinical_measurement_ontology CMO:0000988 heart left ventricle relative wall thickness The thickness or depth of the ventral/anterior wall of the heart. The ventral wall is the portion of the heart muscle which is farthest from the spine and closest to the chest wall of the organism. jsmith 2012-07-30T10:15:23Z clinical_measurement_ontology heart ventral wall thickness CMO:0000990 heart anterior wall thickness jsmith 2012-07-30T10:31:58Z clinical_measurement_ontology Not4Curation CMO:0000991 calculated heart wall thickness measurement jsmith 2012-07-30T11:04:28Z EFO:0009286 clinical_measurement_ontology CMO:0000992 heart relative wall thickness jsmith 2012-07-30T11:05:55Z clinical_measurement_ontology CMO:0000993 heart ventricle relative wall thickness The extent of shortening of the minor internal circumference (at the midpoint of the long axis) between end-diastole and end-systole, divided by the time required for shortening. jsmith 2012-07-30T01:25:59Z VT:0010758 VCFr Vcf circumferential fiber shortening rate clinical_measurement_ontology CMO:0000994 velocity of circumferential fiber shortening The thickness or depth of the ventral/anterior wall of the right ventricle of the heart. The ventral wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism. jsmith 2012-07-30T02:57:57Z clinical_measurement_ontology heart right ventricle ventral wall thickness CMO:0000996 heart right ventricle anterior wall thickness Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation. jsmith 2012-08-02T01:00:46Z VT:0010544 superficial glomeruli count clinical_measurement_ontology CMO:0001000 superficial glomerulus count Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis, and directly in contact with the surface of the kidney, i.e. the renal capsule. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation. jsmith 2012-08-02T01:14:28Z VT:0010544 clinical_measurement_ontology surface glomeruli count CMO:0001001 count of superficial glomeruli directly contacting the kidney surface Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis but without any direct contact with the surface of the kidney, i.e. the renal capsule. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation. jsmith 2012-08-02T01:15:32Z VT:0010544 clinical_measurement_ontology CMO:0001002 count of superficial glomeruli not directly contacting the kidney surface jsmith 2012-08-03T06:05:33Z clinical_measurement_ontology CMO:0001015 heart infarction volume Measurement of any change or difference in the diastolic blood pressure between two points or two conditions. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood. jsmith 2012-08-03T06:17:05Z EFO:0006945 diastolic blood pressure change measurement clinical_measurement_ontology Not4Curation CMO:0001016 change in diastolic blood pressure The relative difference in the diastolic blood pressure between two points or two conditions, expressed as a percentage. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood. jsmith 2012-08-03T06:19:27Z clinical_measurement_ontology CMO:0001017 percent change in diastolic blood pressure Calculated measurement of a difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. jsmith 2012-08-13T01:16:23Z clinical_measurement_ontology CMO:0001019 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in left ventricular systolic blood pressure Temperature measured at the surface of or within the head of an experimental subject. Because the temperature of the head/brain can influence neurological measurements, head temperature is or can be considered to be distinct from core body temperature. jsmith 2012-08-23T03:27:50Z VT:0010936 clinical_measurement_ontology cranial temperature CMO:0001035 head temperature The temperature of the internal tissues and organs of the body. jsmith 2012-08-23T04:06:16Z VT:0005535 clinical_measurement_ontology core temperature CMO:0001036 core body temperature Any measurement, morphological or physiological, involving the liver or any part thereof. The liver is the large, dark-red organ located in the cranial portion of the abdomen of vertebrates, just behind or below the diaphragm, the functions of which include storage and filtration of blood; secretion of bile; detoxification of noxious substances; conversion of sugars into glycogen; synthesis and breakdown of fats and temporary storage of fatty acids; and synthesis of serum proteins. jsmith 2012-09-04T11:02:27Z clinical_measurement_ontology CMO:0001064 liver measurement Measurement of a lesion in the liver, the large, dark-red organ located in the cranial portion of the abdomen of vertebrates, just behind or below the diaphragm, that secretes bile and is active in the formation of certain blood proteins, in the metabolism of carbohydrates, fats, and proteins and in the detoxification of noxious substances. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-09-04T11:34:49Z clinical_measurement_ontology hepatic lesion measurement CMO:0001065 liver lesion measurement Measurement of a liver lesion which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc. jsmith 2012-09-04T11:42:51Z clinical_measurement_ontology hepatic non-tumorous lesion measurement CMO:0001066 liver non-tumorous lesion measurement Measurement of a liver lesion resulting from a process of fibrosis, the proliferation of fibroblasts and fibrous tissue, usually in response to an injury, inflammation or infection. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-09-06T01:12:37Z EFO:0010576 clinical_measurement_ontology liver fibrosis measurement CMO:0001088 liver fibrotic lesion measurement A measurement which has been normalized or adjusted by a mathematical process or computation of the weight of the left ventricle of the heart, that is, its the heaviness or degree to which it is drawn toward the earth by gravity. The heart left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body. jsmith 2012-09-13T06:09:33Z EFO:0009289 VT:0007031 left ventricular mass clinical_measurement_ontology CMO:0001123 calculated heart left ventricle weight jsmith 2012-09-13T06:11:08Z clinical_measurement_ontology CMO:0001124 calculated heart right ventricle weight jsmith 2012-09-13T06:14:55Z clinical_measurement_ontology CMO:0001125 calculated heart right ventricle morphological measurement The length of a line which crosses a transverse view of a cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The cerebral arteries are those which supply blood to the brain, more specifically, to the cerebrum. jsmith 2012-10-03T05:31:53Z clinical_measurement_ontology cerebral artery lumen diameter CMO:0001126 cerebral artery inner diameter The length of a line which crosses a transverse view of an anterior cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The anterior cerebral artery (ACA) is one of a pair of arteries that supply oxygenated blood to the most medial portions of the frontal lobes and superior medial parietal lobes of the brain. jsmith 2012-10-03T05:39:47Z clinical_measurement_ontology ACA inner diameter anterior cerebral artery lumen diameter CMO:0001127 anterior cerebral artery inner diameter The length of a line which crosses a transverse view of a middle cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain. jsmith 2012-10-03T05:48:00Z VT:0010921 clinical_measurement_ontology MCA inner diameter middle cerebral artery lumen diameter CMO:0001128 middle cerebral artery inner diameter The length of a line which crosses a transverse view of a posterior cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The posterior cerebral artery (PCA) is one of a pair of blood vessels that supply blood to the posterior aspect, i.e. the occipital lobe, of the brain. jsmith 2012-10-03T05:59:18Z clinical_measurement_ontology PCA inner diameter posterior cerebral artery lumen diameter CMO:0001129 posterior cerebral artery inner diameter Measurement of a lesion in kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. jsmith 2012-10-08T02:59:36Z clinical_measurement_ontology CMO:0001130 kidney lesion measurement Measurement of a lesion in the kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc. jsmith 2012-10-08T03:01:39Z clinical_measurement_ontology CMO:0001131 kidney non-tumorous lesion measurement Measurement of a lesion in the kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells. jsmith 2012-10-08T03:03:01Z clinical_measurement_ontology CMO:0001132 kidney tumorous lesion measurement Any measurement of lesions resulting from fibrosis, scarring or hyaline deposits within a kidney glomerulus, a tuft of capillaries situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney, that filters waste products from the blood and thus initiates urine formation. jsmith 2012-10-08T03:09:04Z clinical_measurement_ontology kidney glomerulosclerosis measurement renal glomerulosclerosis measurement renal glomerulosclerotic lesion measurement CMO:0001133 kidney glomerulosclerotic lesion measurement A measurement of lesions resulting from fibrosis, scarring or hyaline deposits within one or more kidney glomeruli which has been normalized, adjusted or derived by a mathematical process or computation. jsmith 2012-10-08T03:43:25Z clinical_measurement_ontology calculated kidney glomerulosclerosis measurement calculated renal glomerulosclerosis measurement calculated renal glomerulosclerotic lesion measurement CMO:0001134 calculated kidney glomerulosclerotic lesion measurement A measurement of lesions resulting from fibrosis, scarring or hyaline deposits within kidney glomeruli which is derived from a combination of multiple measurements and/or objective or subjective severity scores according to a specified formula or set of criteria. jsmith 2012-10-08T03:45:56Z clinical_measurement_ontology glomerular damage composite score glomerulosclerosis composite score glomerulosclerosis damage index CMO:0001135 index of glomerular damage Any measurement of the physical form or structure of skeletal muscles, the striated muscles attached to bones. jsmith 2012-10-10T03:52:11Z clinical_measurement_ontology CMO:0001147 skeletal muscle morphological measurement The weight of all or part of a skeletal muscle, one of the striated muscles attached to bones. jsmith 2012-10-10T04:01:31Z clinical_measurement_ontology CMO:0001148 skeletal muscle weight Any measurement, morphological or physiological of a muscle or a group of muscles. Muscles are organs or tissues composed of bundles of fibers that have the power to contract and hence to produce movement. jsmith 2012-10-12T05:28:37Z EFO:0004515 clinical_measurement_ontology CMO:0001158 muscle measurement Any measurement, morphological or physiological, of all or part of the skeletal system, the body's framework of bones which give support and shape to the body, protect delicate internal organs, provide sites of attachment for muscles to make motion possible, manufacture blood cells and store minerals. jsmith 2012-10-12T05:38:14Z clinical_measurement_ontology skeleton measurement CMO:0001159 skeletal system measurement Measurement of the physical form or structure of one or more glomeruli in the kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation. jsmith 2012-10-15T11:45:27Z clinical_measurement_ontology CMO:0001165 kidney glomerulus morphological measurement The length of a straight line passing through the center of a kidney glomerulus and connecting opposite points on its circumference. jsmith 2012-10-15T11:48:00Z VT:0010925 capillary tuft diameter kidney glomerular diameter clinical_measurement_ontology CMO:0001166 kidney glomerulus diameter A measurement of the volume of blood delivered to or exiting from the kidneys per unit time, which has been normalized, adjusted or derived by a mathematical process or computation. jsmith 2012-10-15T11:55:42Z clinical_measurement_ontology CMO:0001167 calculated renal blood flow rate The difference in the volume of blood delivered to or exiting from the kidneys per unit time between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. jsmith 2012-10-15T11:59:32Z clinical_measurement_ontology CMO:0001168 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in renal blood flow rate The number of kidney glomeruli with lesions resulting from fibrosis, scarring or hyaline deposits, or the number of such lesions in a specified sample. jsmith 2012-10-22T12:14:30Z VT:0010546 clinical_measurement_ontology damaged glomeruli count number of sclerotic glomeruli sclerotic glomeruli count sclerotic glomerulus count CMO:0001175 kidney glomerulosclerotic lesion count Any measurement involving the composition, that is, the absolute amount, relative amount or type of one or more proteins (complex high molecular weight organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) or peptides (low molecular weight compounds composed of at least two amino acids joined by peptide linkages) in kidney. jsmith 2012-10-22T01:31:20Z kidney tissue protein/peptide composition measurement clinical_measurement_ontology CMO:0001177 kidney protein/peptide composition measurement Any measurement, morphological or physiological of the outer part of the kidney, composed mainly of glomeruli and convoluted tubules. jsmith 2012-10-22T03:13:42Z kidney cortex measurement clinical_measurement_ontology CMO:0001178 renal cortex measurement Any measurement, morphological or physiological, of the renal medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. jsmith 2012-10-22T03:20:09Z kidney medulla measurement clinical_measurement_ontology CMO:0001179 renal medulla measurement Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in kidney medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. jsmith 2012-10-22T03:28:36Z kidney medulla protein measurement clinical_measurement_ontology CMO:0001180 renal medulla protein measurement Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in renal cortex, the outer part of the kidney, composed mainly of glomeruli and convoluted tubules. jsmith 2012-10-22T03:31:18Z kidney cortex protein measurement clinical_measurement_ontology CMO:0001181 renal cortex protein measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the composition, that is, the absolute amount, relative amount or type, of protein (the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) in kidney. jsmith 2012-10-22T03:34:08Z clinical_measurement_ontology calculated renal protein composition measurement CMO:0001182 calculated kidney protein composition measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation involving the amount, composition or type of protein in the kidney cortex, the outer part of the kidney, composed mainly of glomeruli and convoluted tubules. jsmith 2012-10-22T03:41:53Z clinical_measurement_ontology calculated kidney cortex protein composition measurement CMO:0001183 calculated renal cortex protein composition measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation involving the amount, composition or type of protein in the renal medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. jsmith 2012-10-22T03:43:38Z calculated kidney medulla protein composition measurement clinical_measurement_ontology CMO:0001184 calculated renal medulla protein composition measurement A calculated value in which the amount of TRPV4 protein in a specified sample of kidney is divided by the amount of beta-actin protein in the same or a corresponding sample of kidney and presented as a ratio, fraction or quotient, thus normalizing it to the beta-actin protein level. jsmith 2012-10-22T04:00:13Z renal TRPV4 protein level to beta-actin protein level ratio clinical_measurement_ontology CMO:0001185 kidney TRPV4 protein level to beta-actin protein level ratio A calculated value in which the amount of TRPV4 protein in a specified sample of renal cortex is divided by the amount of beta-actin protein in the same or a corresponding sample of renal cortex and presented as a ratio, fraction or quotient, thus normalizing it to the beta-actin protein level. jsmith 2012-10-22T04:33:48Z kidney cortex TRPV4 protein level to beta-actin protein level ratio clinical_measurement_ontology CMO:0001186 renal cortex TRPV4 protein level to beta-actin protein level ratio A calculated value in which the amount of TRPV4 protein in a specified sample of renal medulla is divided by the amount of beta-actin protein in the same or a corresponding sample of renal medulla and presented as a ratio, fraction or quotient, thus normalizing it to the beta-actin protein level. jsmith 2012-10-22T04:35:29Z clinical_measurement_ontology kidney medulla TRPV4 protein level to beta-actin protein level ratio CMO:0001187 renal medulla TRPV4 protein level to beta-actin protein level ratio The length of a line which crosses a transverse view of a cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall, after that measurement has been normalized or adjusted by a mathematical process or computation. The cerebral arteries are those which supply blood to the brain, more specifically, to the cerebrum. jsmith 2012-10-23T10:05:50Z clinical_measurement_ontology CMO:0001188 calculated cerebral artery inner diameter measurement The length of a line which crosses a transverse view of a middle cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall, after that measurement has been normalized or adjusted by a mathematical process or computation. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain. jsmith 2012-10-23T10:06:14Z clinical_measurement_ontology CMO:0001189 calculated middle cerebral artery inner diameter measurement This is a calculated measurement of the relative difference in the middle cerebral artery inner diameter between a treated, fully relaxed state and a control resting state, expressed as a percentage. This calculated value is given by this equation: [(Dmax - Drest) /Dmax] x 100. jsmith 2012-10-23T10:09:32Z VT:0002191 active resting tone of middle cerebral artery active tone of MCA spontaneous resting tone of MCA tone of middle cerebral artery clinical_measurement_ontology CMO:0001190 resting tone of middle cerebral artery A measurement of the extent of a two-dimensional plane through the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter. jsmith 2012-11-12T15:45:39Z VT:0002753 clinical_measurement_ontology EDA LVAd LVDa CMO:0001191 heart left ventricle end-diastolic area A measurement of the extent of a two-dimensional plane through the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter. jsmith 2012-11-12T15:47:47Z clinical_measurement_ontology ESA LVAs LVSa CMO:0001192 heart left ventricle end-systolic area jsmith 2012-11-15T15:29:02Z clinical_measurement_ontology Not4Curation calculated body mass measurement CMO:0001196 calculated body weight measurement A calculated value in which the weight of the heart, the chambered, muscular organ that maintains the circulation of the blood, is divided by the length of the tibia, the inner and larger bone of the lower leg or hindlimb, and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the length of the leg and, by extension, to the length of the body. jsmith 2012-11-15T15:35:17Z VT:0007028 clinical_measurement_ontology CMO:0001198 heart weight to tibia length ratio A calculated value in which the total weight after removal from the body but without desiccation of both kidneys is divided by the length of the tibia, the inner and larger bone of the lower leg or hindlimb, and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the length of the leg and, by extension, to the length of the body. jsmith 2012-11-15T15:38:38Z VT:0002707 clinical_measurement_ontology CMO:0001199 both kidneys wet weight to tibia length ratio A calculated measurement of the ratio between the change in mean arterial blood pressure and the concentration of sodium infused directly into the ventricle(s) of the brain; calculated as the slope of the curve of mean arterial blood pressure versus intracerebroventricular-infused sodium concentration. jsmith 2013-01-07T13:24:24Z clinical_measurement_ontology CMO:0001230 change in mean arterial blood pressure to change in intracerebroventricular sodium concentration ratio A calculated measurement of the ratio between the change in heart rate and the concentration of sodium infused directly into the ventricle(s) of the brain; calculated as the slope of the curve of heart rate versus intracerebroventricular-infused sodium concentration. jsmith 2013-01-07T13:34:46Z clinical_measurement_ontology CMO:0001231 change in heart rate to change in intracerebroventricular sodium concentration ratio A value calculated by dividing the proportionate change in renal blood flow (RBF) by the proportionate change in renal perfusion pressure (RPP), i.e. (RBF2 - RBF1)/RBF1 divided by (RPP2 - RPP1)/RPP1. jsmith 2013-01-07T15:55:09Z VT:2000006 clinical_measurement_ontology autoregulatory index ratio of renal blood flow change to renal perfusion pressure change CMO:0001239 ratio of change in renal blood flow to change in renal perfusion pressure Any measurement of a lesion in the kidney characterized by an abnormal proliferation of fibrous connective tissue. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. jsmith 2013-01-08T14:41:50Z clinical_measurement_ontology CMO:0001254 kidney fibrotic lesion measurement Any measurement of the physical dimensions, proportions, magnitude, or extent of a lesion in the kidney characterized by an abnormal proliferation of fibrous connective tissue. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. jsmith 2013-01-08T14:54:45Z clinical_measurement_ontology CMO:0001255 kidney fibrotic lesion size measurement A measurement of the extent of a two-dimensional surface of or plane through a single kidney fibrotic lesion, or a measurement of the total area occupied by fibrotic lesions in a cross-section of the kidney. jsmith 2013-01-08T15:03:27Z clinical_measurement_ontology CMO:0001256 kidney fibrotic lesion area measurement A measurement of the extent of a two-dimensional surface of or plane through a single kidney fibrotic lesion, or a measurement of the total area occupied by fibrotic lesions in a cross-section of the kidney, when that value has been normalized, adjusted or derived by a mathematical process or computation. jsmith 2013-01-08T15:17:52Z clinical_measurement_ontology CMO:0001257 calculated kidney fibrotic lesion area measurement A calculated value in which the number of glomeruli with lesions resulting from fibrosis, scarring or hyaline deposits is divided by the total number of glomeruli in a specified sample of kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total number of glomeruli. jsmith 2013-01-08T16:28:12Z CMO:0001176 sclerotic glomeruli to total glomeruli ratio VT:0010546 kidney glomerulosclerotic lesion count to total glomeruli count ratio clinical_measurement_ontology CMO:0001269 kidney sclerotic glomeruli count to total glomeruli count ratio The combined weight of both ventricles of the heart, that is, their heaviness or the degree to which they are drawn toward the earth by gravity. The ventricles are the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body. jsmith 2013-01-09T15:09:49Z clinical_measurement_ontology CMO:0001316 total heart ventricle weight A measurement of the combined weight of both heart ventricles that has been normalized, adjusted or derived by a mathematical process or computation. jsmith 2013-01-09T16:00:43Z clinical_measurement_ontology Not4Curation CMO:0001317 calculated total heart ventricle weight A calculated value in which the combined weight of both the left and right ventricles, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body, is presented as percentage of the total weight of the body thus normalizing it to body weight. jsmith 2013-01-09T16:03:12Z clinical_measurement_ontology CMO:0001318 total heart ventricle weight as a percentage of body weight Any measurement of the cavity or channel within an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. jsmith 2013-01-15T10:37:51Z clinical_measurement_ontology CMO:0001408 artery lumen measurement A measurement of the two-dimensional extent of the enclosed cavity or channel in a cross-section of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. For an artery with a neointimal lesion, the cross-sectional area of the lesion would be subtracted from the circular vessel area to obtain the artery lumen area. jsmith 2013-01-15T10:50:23Z PMID:10364562 VT:0002191 VT:0010643 LS lumen size clinical_measurement_ontology CMO:0001409 artery lumen area Any measurement of the fibrous and muscular structure of one of the large blood vessels carrying blood in a direction away from the heart to the tissues. The wall of an artery is composed of three layers: the tunica intima, the inner coat; the tunica media, the middle coat; and the tunica adventitia, the outer coat. jsmith 2013-01-15T11:04:30Z arterial wall measurement clinical_measurement_ontology CMO:0001410 artery wall measurement Any measurement of the tunica media, or middle coat, of the wall of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. jsmith 2013-01-15T11:17:48Z arterial tunica media measurement clinical_measurement_ontology CMO:0001411 artery tunica media measurement A direct measurement of two dimensional extent of the tunica media, the middle coat of the arterial wall, in a cross-section of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. The total area of the tunica media gives an indication of the thickness of the arterial wall. jsmith 2013-01-15T11:21:04Z VT:0000530 VT:0002191 VT:0010643 VT:0011164 arterial tunica media area clinical_measurement_ontology media area (MA) of artery CMO:0001412 artery tunica media area A calculated measurement of the average width of the tunica media, the middle layer of the arterial wall. Can be calculated using the media area and the length of the internal elastic lamina. jsmith 2013-01-15T11:34:35Z VT:0002191 VT:0010641 VT:0010643 arterial tunica media width artery tunica media width clinical_measurement_ontology media width (MW) of artery CMO:0001413 artery tunica media thickness A measurement of the extent of a two-dimensional surface of or plane through a single hyperplastic lesion of the tunica intima, that is, the inner coat of the arterial wall, or a measurement of the total area occupied by hyperplastic lesions of the tunica intima in a cross-section of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. A hyperplastic lesion is a localized pathological increase in the number of cells of an organ or tissue resulting from an increased rate of cellular division due to injury or disease; especially one that is circumscribed and well defined. jsmith 2013-01-15T12:10:01Z VT:0010639 VT:0010644 artery intimal hyperplastic lesion area neointimal hyperplasia area of artery clinical_measurement_ontology CMO:0001414 artery neointimal hyperplastic lesion area Any measurement of one or more hyperplastic lesions of the arterial tunica intima which has been normalized, adjusted or derived by a mathematical process. jsmith 2013-01-15T12:33:00Z calculated arterial intima hyperplasia area clinical_measurement_ontology CMO:0001415 calculated artery neointimal hyperplastic lesion area A calculated measurement in which the area of the arterial tunica intima occupied by one or more hyperplastic lesions is divided by the total cross-sectional area of the artery wall and presented as a ratio, fraction, quotient or percentage. jsmith 2013-01-15T12:33:16Z VT:0010639 VT:0010644 ratio of neointimal hyperplasia area to total wall area of artery clinical_measurement_ontology CMO:0001416 artery neointimal hyperplastic lesion area to total wall area ratio The area of the arterial lumen remaining when the luminal space is restricted by a pathological process, e.g. hyperplasia. jsmith 2013-01-15T12:50:46Z VT:0010639 VT:0010644 residual lumen area of diseased artery clinical_measurement_ontology CMO:0001417 lesioned artery residual lumen area The weight after desiccation of both kidneys, the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-01-16T13:36:09Z clinical_measurement_ontology CMO:0001425 both kidneys dry weight The weight after desiccation of a single kidney, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-01-16T13:36:57Z individual kidney dry weight clinical_measurement_ontology CMO:0001426 single kidney dry weight Any measurement of the great artery arising from the left ventricle from which the systemic arterial system proceeds. jsmith 2013-01-21T16:32:31Z EFO:0020865 aortic measurement clinical_measurement_ontology CMO:0001474 aorta measurement Any quantification of the physical form or structure of the great artery arising from the left ventricle from which the systemic arterial system proceeds. jsmith 2013-01-21T16:37:23Z clinical_measurement_ontology CMO:0001475 aorta morphological measurement The speed at which the blood flows through the circulatory system or through a specific segment of a vein or artery, expressed as distance per unit of time. jsmith 2013-01-25T12:50:21Z clinical_measurement_ontology CMO:0001476 blood flow velocity The speed at which the blood flows through an artery, expressed as distance per unit of time. jsmith 2013-01-25T12:56:43Z clinical_measurement_ontology CMO:0001477 arterial blood flow velocity The speed at which the blood flows through the aorta, the great artery arising from the left ventricle from which the systemic arterial system proceeds, expressed as distance per unit of time. jsmith 2013-01-25T13:10:05Z clinical_measurement_ontology CMO:0001478 aortic blood flow velocity Any measurement of the movement of blood through the aorta, the great artery arising from the left ventricle from which the systemic arterial system proceeds. jsmith 2013-01-25T13:15:01Z clinical_measurement_ontology CMO:0001479 aortic blood flow measurement The volume of blood flowing through the aorta, the great artery arising from the left ventricle from which the systemic arterial system proceeds, per unit of time. jsmith 2013-01-25T13:18:41Z clinical_measurement_ontology CMO:0001480 aortic blood flow rate The maximum speed at which the blood flows through the aorta during the cardiac cycle, expressed as distance per unit of time. jsmith 2013-01-25T13:21:50Z EFO:0022982 VT:0010490 aortic peak velocity (APV) maximum aortic velocity peak aortic blood flow velocity peak of aortic outflow velocity (PAV) clinical_measurement_ontology CMO:0001481 peak aortic velocity The length of time in the cardiac cycle between the closing of the aortic and pulmonic/pulmonary semilunar valves and opening of the atrioventricular (AV) valves marking the beginning of ventricular filling. Used as an indicator of diastolic dysfunction. jsmith 2013-01-25T13:29:29Z VT:2000020 clinical_measurement_ontology IVRT CMO:0001482 heart isovolumetric relaxation time Measurement of the physical form or structure of the left upper chamber of the heart that receives blood from the veins and forces it into the left ventricle. jsmith 2013-01-25T13:35:08Z clinical_measurement_ontology CMO:0001483 heart left atrium morphological measurement Measurement of the physical form or structure of the right upper chamber of the heart that receives blood from the veins and forces it into the right ventricle. jsmith 2013-01-25T13:42:05Z clinical_measurement_ontology CMO:0001484 heart right atrium morphological measurement The distance between two specified opposite points on the periphery of the left atrium of the heart at the end of systole, that is, when the left ventricle is maximally contracted, and usually corresponds to the left atrium's largest diameter. jsmith 2013-01-25T13:51:15Z VT:0010493 clinical_measurement_ontology CMO:0001485 heart left atrium end-systolic diameter The distance between two specified opposite points on the periphery of the left atrium of the heart at the end of diastole, that is, when the left ventricle is maximally dilated, and usually corresponds to the left atrium's smallest diameter. jsmith 2013-01-25T15:50:33Z VT:0010493 clinical_measurement_ontology CMO:0001486 heart left atrium end-diastolic diameter A measurement of the physical form or structure of the left atrium, the left upper chamber of the heart that receives blood from the veins and forces it into the left ventricle, which has been normalized, adjusted or derived by a mathematical process or computation. jsmith 2013-01-25T15:51:30Z clinical_measurement_ontology CMO:0001487 calculated heart left atrium morphological measurement A calculated measurement corresponding to the ratio or percent reduction in left atrial diameter between end-systole and end-diastole. It is calculated as the left atrium end-systolic diameter (LADs) minus the left atrium end-diastolic diameter (LADd) divided by the left atrium end-systolic diameter (LADs). jsmith 2013-01-25T16:00:18Z VT:0010493 clinical_measurement_ontology CMO:0001488 heart left atrium fractional shortening Measurement of the number of white blood cells, including lymphocytes and monocytes, with a single round or oval nucleus in a specified volume of blood. jsmith 2013-01-28T16:41:10Z VT:0000217 clinical_measurement_ontology mononuclear leukocyte count CMO:0001495 blood mononuclear cell count A measurement of the movement of blood through one or more vessels or organs in the body which has been normalized, adjusted or derived by a mathematical process or computation. jsmith 2013-01-30T14:16:47Z clinical_measurement_ontology CMO:0001543 calculated blood flow measurement Any measurement of the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart wall. jsmith 2013-03-15T17:22:25Z clinical_measurement_ontology CMO:0001544 myocardium measurement The volume of fluid flowing into, out of or through the blood vessels and microvasculature of the myocardium, the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart wall, per unit time. jsmith 2013-03-15T17:29:25Z VT:2000004 MBF myocardial blood flow clinical_measurement_ontology CMO:0001545 myocardial flow rate Measurement of the amount of radioactive or other tracer lost from the myocardium, the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart wall, per unit time. jsmith 2013-03-15T17:38:35Z VT:0010110 clinical_measurement_ontology CMO:0001546 myocardial clearance rate A value resulting from the quantification of a morphological or physiological parameter of vascular smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of blood vessels, the network of muscular tubes that carry blood through the body. jsmith 2013-06-18T10:33:25Z vascular smooth muscle measurement clinical_measurement_ontology Not4Curation CMO:0001640 blood vessel smooth muscle measurement Any quantification of the physical form or structure of the layered tissue which encloses and constitutes the structural component of the great artery arising from the left ventricle from which the systemic arterial system proceeds. jsmith 2013-06-18T10:41:10Z aortic wall morphological measurement clinical_measurement_ontology CMO:0001641 aorta wall morphological measurement Measurement of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of the aorta smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of the great artery arising from the left ventricle from which the systemic arterial system proceeds. jsmith 2013-06-18T10:42:34Z aortic smooth muscle cell count clinical_measurement_ontology CMO:0001642 aorta smooth muscle cell count Measurement of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of vascular smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of blood vessels, the network of muscular tubes that carry blood through the body. jsmith 2013-06-18T11:29:28Z vascular smooth muscle cell count clinical_measurement_ontology CMO:0001643 blood vessel smooth muscle cell count A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of vascular smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of blood vessels, the network of muscular tubes that carry blood through the body. jsmith 2013-06-18T12:57:40Z calculated vascular smooth muscle cell count clinical_measurement_ontology CMO:0001644 calculated blood vessel smooth muscle cell count A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of the aorta smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of the great artery arising from the left ventricle from which the systemic arterial system proceeds. jsmith 2013-06-18T12:59:11Z calculated aortic smooth muscle cell count clinical_measurement_ontology CMO:0001645 calculated aorta smooth muscle cell count A calculated value in which the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of the aorta smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of the great artery arising from the left ventricle from which the systemic arterial system proceeds, is divided by the length of the smooth muscle section in which that number is determined. jsmith 2013-06-18T13:25:39Z VT:0010525 aortic smooth muscle cell count per unit vessel length clinical_measurement_ontology CMO:0001646 aorta smooth muscle cell count per unit vessel length The amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart left ventricle, the lower chamber of the left side of the heart (from the perspective of the organism rather than the observer), which pumps oxygenated blood out through the aorta to all the tissues of the body. jsmith 2013-06-18T14:44:11Z clinical_measurement_ontology heart LV DNA content heart left ventricle DNA content CMO:0001647 heart left ventricle deoxyribonucleic acid composition measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart left ventricle, the lower chamber of the left side of the heart (from the perspective of the organism rather than the observer), which pumps oxygenated blood out through the aorta to all the tissues of the body. jsmith 2013-06-18T14:46:40Z clinical_measurement_ontology calculated heart LV DNA content calculated heart left ventricle DNA content CMO:0001648 calculated heart left ventricle deoxyribonucleic acid composition measurement A calculated measurement in which amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart left ventricle, the lower chamber of the left side of the heart (from the perspective of the organism rather than the observer), which pumps oxygenated blood out through the aorta to all the tissues of the body, is divided by the total weight or heaviness of the body and presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism. jsmith 2013-06-18T14:49:33Z VT:0010565 clinical_measurement_ontology heart LV DNA content to body weight ratio heart left ventricle DNA content to BW ratio heart left ventricle DNA content to body weight ratio CMO:0001649 heart left ventricle deoxyribonucleic acid level to body weight ratio The amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung. jsmith 2013-06-18T14:52:32Z clinical_measurement_ontology heart RV DNA content heart right ventricle DNA content CMO:0001650 heart right ventricle deoxyribonucleic acid composition measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung. jsmith 2013-06-18T14:54:27Z clinical_measurement_ontology calculated heart RV DNA content calculated heart right ventricle DNA content CMO:0001651 calculated heart right ventricle deoxyribonucleic acid composition measurement A calculated measurement in which amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is divided by the total weight or heaviness of the body and presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism. jsmith 2013-06-18T14:56:34Z VT:0010564 clinical_measurement_ontology heart RV DNA content to body weight ratio heart right ventricle DNA content to BW ratio heart right ventricle DNA content to body weight ratio CMO:0001652 heart right ventricle deoxyribonucleic acid level to body weight ratio Measurement of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from a contraction of the muscular wall of the vessel which does not involve the action of a receptor, a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect. jsmith 2013-06-20T14:09:54Z clinical_measurement_ontology blood vessel receptor-independent maximum contractility CMO:0001653 receptor-independent blood vessel maximum contractile force Measurement of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from a contraction of the muscular wall of the vessel which is instigated by the activation of a receptor, a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect. jsmith 2013-06-20T14:10:59Z clinical_measurement_ontology blood vessel receptor-dependent maximum contractility CMO:0001654 receptor-dependent blood vessel maximum contractile force A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel. jsmith 2013-06-20T14:12:17Z clinical_measurement_ontology CMO:0001655 calculated blood vessel maximum contractile force measurement A calculated measurement in which the receptor-dependent maximum contractile force of a blood vessel is divided by the receptor-independent maximum contractile force of a blood vessel and presented as a ratio, fraction, quotient or percentage. The maximum contractile force of a blood vessel is the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from a contraction of the muscular wall of the vessel. Receptor-dependent refers to such a contraction which is instigated by the activation of a receptor, a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect. Receptor-independent denotes such a contraction that does not involve the action of a receptor. jsmith 2013-06-20T14:14:00Z VT:0000198 clinical_measurement_ontology blood vessel receptor-dependent contractility to receptor-independent contractility ratio receptor-dependent blood vessel maximum contractile force exoressed as a percentage of receptor-independent blood vessel maximum contractile force CMO:0001656 receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio A calculated value for the concentration of angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of AngII is halfway between the baseline value and the highest achievable value of such AngII-induced contractile energy. jsmith 2013-06-20T14:22:08Z CHEBI:48432 clinical_measurement_ontology Ang2 half maximal effective concentration AngII half maximal effective concentration angiotensin 2 half maximal effective concentration angiotensin II half maximal effective concentration (EC50) CMO:0001657 concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (EC50) A calculated value for logarithm of the concentration of angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of AngII is halfway between the baseline value and the highest achievable value of such AngII-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. jsmith 2013-06-20T14:24:41Z CHEBI:48432 VT:0000198 clinical_measurement_ontology Ang2 Log half maximal effective concentration AngII Log half maximal effective concentration angiotensin 2 Log half maximal effective concentration angiotensin II Log half maximal effective concentration (EC50) CMO:0001658 logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion. jsmith 2013-06-20T15:45:33Z CHEBI:48432 clinical_measurement_ontology CMO:0001659 angiotensin II response/sensitivity measurement The difference in left ventricular diastolic blood pressure between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. jsmith 2013-07-31T13:40:52Z clinical_measurement_ontology absolute change in LVDBP CMO:0001743 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in left ventricular diastolic blood pressure Any measurement of the blood pressure in the left ventricle of the heart which has been normalized or adjusted by a mathematical process or computation. Left ventricular blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body. jsmith 2013-07-31T15:17:53Z calculated left ventricular pressure clinical_measurement_ontology CMO:0001744 calculated left ventricular blood pressure A calculated measurement that is used as an index to characterize the contractile ability of the heart. It is believed that maximum dP/dt is a reasonable index of the initial velocity of myocardial contraction. jsmith 2013-07-31T15:24:11Z PMID:32207065 VT:0010750 LV dP/dt Max LVdP/dtmax dP/dtmax maximal slope of the systolic pressure increment peak LV +dP/dt rate of maximum positive change in left ventricular blood pressure clinical_measurement_ontology CMO:0001745 maximum rate of positive change in left ventricular blood pressure A calculated hemodynamic measurement related to the ability of the heart left ventricle to relax. The point at which the negative pressure fall velocity reaches its peak is taken to be the onset of isovolumic relaxation of the left ventricle. jsmith 2013-07-31T15:27:12Z PMID:32207065 VT:0010750 maximal slope of the diastolic pressure decrement clinical_measurement_ontology dP/dtmin peak LV -dP/dt rate of maximum negative change in left ventricular blood pressure CMO:0001746 maximum rate of negative change in left ventricular blood pressure A calculated hemodynamic value related to the ability of the heart left ventricle to relax. Tau is calculated as an exponential function of the change in intraventricular pressure during the diastolic isovolumic left ventricular pressure decrease. jsmith 2013-07-31T15:29:00Z left ventricular function EFO:0004295 VT:0010750 Left ventricular relaxation time constant P/(&#8722;dP/dt) T Tau time constant of left ventricular relaxation clinical_measurement_ontology CMO:0001747 time constant of left ventricular pressure decay The thickness or depth (i.e. the measurement of the two-dimensional extent of the distance between the inner and outer surfaces) of the dorsal/posterior wall of the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body. jsmith 2013-10-16T12:18:32Z VT:0007087 end-systolic heart left ventricle posterior wall thickness clinical_measurement_ontology end-systolic heart left ventricle PWT CMO:0001840 Note that "left" in this context refers to the perspective of the organism, not that of the observer. heart left ventricle end-systolic posterior wall thickness Any quantification of the amounts or proportions of proteins, lipids, minerals, nutrients, gases, or other substances in a specified sample of kidney tissue, that is, tissue from one or both of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-04T17:14:28Z renal molecular composition measurement clinical_measurement_ontology CMO:0001852 kidney molecular composition measurement Quanitification of one or more lipids in a specified sample of kidney tissue, that is, tissue from one or both of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. A lipid is any of a structurally diverse group of organic compounds that are insoluble in water but soluble innonpolar solvents that, among other biological functions, serve as a source of fuel and are an important constituent of cell structure. jsmith 2013-11-04T17:16:16Z clinical_measurement_ontology CMO:0001853 kidney lipid composition measurement The amount of 20-hydroxyeicosatetraenoic acid, a vasoconstrictor that consists of arachidonic acid (a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14) bearing a hydroxy substituent at position 20, in a specified sample of kidney tissue, that is, tissue from one or both of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-04T17:22:56Z CHEBI:34306 kidney 20-hydroxyeicosatetraenoic acid level clinical_measurement_ontology CMO:0001854 kidney 20-HETE level Any value resulting from the quantification of a morphological or physiological parameter of one or more of the cells of the immune system, a complex set of interconnected and interdependent cellular and molecular components having the primary functions of distinguishing self from not self and of defense against foreign organisms or substances. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning. jsmith 2013-11-07T16:05:25Z clinical_measurement_ontology CMO:0001864 immune cell measurement The difference in the pulse pressure of an individual between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. Pulse pressure is the difference between systolic and diastolic blood pressures, i.e. the difference between the maximal arterial pressure and minimal arterial pressure during the cardiac cycle. jsmith 2013-11-08T16:00:08Z clinical_measurement_ontology CMO:0001882 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in pulse pressure A calculated measurement of the degree to which a change in the size of the remaining kidney after surgical removal of the other kidney can be attributed to compensatory growth, calculated as the ratio of the normalized weight of a single kidney at the time of surgical removal divided by the similarly normalized weight of the single remaining kidney at a specified period of time after removal. The normalized kidney weight is the weight of the kidney corrected for body weight using an empirically determined allometric scaling factor (i.e., an exponential factor which adjusts for the normal increase in kidney weight due to normal growth and development of the individual). Compensatory growth is the phenomenon in which the impaired function of one organ in a paired organ system or of part of an organ in a single organ system is followed by enlargement of the surviving organ or tissue so that functional capacity is maintained. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-18T15:00:01Z clinical_measurement_ontology CRG score CMO:0001894 compensatory renal growth score A calculated measurement in which the difference in the volume of blood delivered to and/or exiting from the kidneys per unit time between two points in time or two conditions is divided by the weight (heaviness or degree to which a body is drawn toward the earth by gravity) of one or both kidneys, and presented as a ratio, fraction, quotient or percentage. The kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-18T16:20:39Z VT:2000006 clinical_measurement_ontology CMO:0001897 ratio of change in renal blood flow rate to kidney weight A measurement of the degree to which the blood vessels of the kidneys impede the flow of blood through them. Renal vascular resistance is calculated as the renal blood flow rate divided by the mean arterial pressure. jsmith 2013-11-18T17:22:16Z VT:2000006 kidney vascular resistance clinical_measurement_ontology CMO:0001898 renal vascular resistance A measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the degree to which the blood vessels of the kidneys impede the flow of blood through them. Blood vessels are the network of muscular tubes that carry blood throughout the body. Blood is the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-18T17:23:40Z calculated kidney vascular resistance clinical_measurement_ontology CMO:0001899 calculated renal vascular resistance The difference in renal vascular resistance between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. Renal vascular resistance is the degree to which the blood vessels of the kidneys impede the flow of blood through them. Blood vessels are the network of muscular tubes that carry blood throughout the body. Blood is the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-18T17:26:57Z absolute change in kidney vascular resistance clinical_measurement_ontology CMO:0001900 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in renal vascular resistance A calculated measurement of the slope, the ratio of vertical change to horizontal change, of the line of a graph designating the change in renal vascular resistance in response to a drug or other condition which causes constriction or reduction of the interior diameter of blood vessels. Renal vascular resistance is the degree to which the blood vessels of the kidneys impede the flow of blood through them. Blood vessels are the network of muscular tubes that carry blood throughout the body. Blood is the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-18T17:27:01Z slope of constriction-induced renal vascular resistance curve slope of contraction-induced kidney vascular resistance curve clinical_measurement_ontology CMO:0001901 slope of contraction-induced renal vascular resistance curve The enumeration, i.e. measurement of the total number, of defects or lesions of the internal elastic lamina which are not hyperplastic or neoplastic in origin in a specified sample of artery. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. The internal elastic lamina (IEL) is a fenestrated (perforated) layer of elastic tissue, i.e., one having the property of returning to the original shape after being distorted, that is the outermost part of the intima (innermost layer) of an artery. The IEL is the elastic layer that is situated between the tunica intima (inner layers) and tunica media (middle layers) of artery walls. An artery is any one of the branching system of muscular, elastic blood vessels that carry blood away from the heart. jsmith 2013-11-19T13:00:18Z clinical_measurement_ontology artery internal elastic lamina defect count CMO:0001913 artery internal elastic lamina non-tumorous lesion count The amount of plasma that perfuses the kidneys per unit time. Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-19T14:28:34Z VT:0005524 renal plasma flow rate clinical_measurement_ontology RPF CMO:0001914 renal plasma flow A calculated measurement in which the renal plasma flow rate (RPF) is divided by weight (i.e. the heaviness or the degree to which an object is drawn toward the earth by gravity) of one kidney and presented as a ratio, fraction, quotient or percentage. The RPF is the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of a non-metabolizable solute such as para-aminohippurate (PAH) or inulin. Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-19T14:51:51Z RGD:25314254 effective renal plasma flow rate to both kidney weight ratio clinical_measurement_ontology eRPF to both kidney weight ratio ratio of the effective renal plasma flow to kidney weight CMO:0001915 ratio of renal plasma flow to kidney weight A calculated measurement of the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of a non-metabolizable solute such as para-aminohippurate (PAH). The effective RPF is approximately 10% less than the actual RPF. Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-19T14:52:06Z VT:0005524 effective renal plasma flow rate clinical_measurement_ontology eRPF CMO:0001916 effective renal plasma flow A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of plasma that perfuses the kidneys per unit time. Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-19T14:52:10Z calculated RPF calculated renal plasma flow rate clinical_measurement_ontology CMO:0001917 calculated renal plasma flow Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the weight of only one of the kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-26T15:36:46Z VT:0002707 clinical_measurement_ontology CMO:0001951 calculated single kidney weight Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the weight of both (the complete set of two) of the kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. jsmith 2013-11-26T15:39:42Z clinical_measurement_ontology CMO:0001952 calculated both kidneys weight A calculated measurement in which the weight after removal from the body but without desiccation of only the single right kidney is divided by the total weight of the body and presented as a ratio, fraction, quotient or percent, thus normalizing it to body weight and by extension to the size of the organism. The right kidney is the organ which lies on the right side of the body from the perspective of the subject. jsmith 2013-11-26T15:48:04Z VT:0002707 individual right kidney wet weight to body weight ratio clinical_measurement_ontology CMO:0001953 right kidney wet weight to body weight ratio A calculated measurement in which the weight after removal from the body but without desiccation of only the left kidney is divided by the total weight of the body and presented as a ratio, fraction, quotient or percent, thus normalizing it to body weight and, by extension, to the size of the organism. The left kidney is the organ which lies on the left side of the body from the perspective of the subject. jsmith 2013-11-26T15:48:07Z VT:0002707 individual left kidney wet weight to body weight ratio clinical_measurement_ontology CMO:0001954 left kidney wet weight to body weight ratio A calculated measurement in which the value for the volume of blood delivered to and/or exiting from the kidneys per unit time is divided by the weight (heaviness or degree to which an object is drawn toward the earth by gravity) of one or both kidneys, and presented as a ratio, fraction, quotient or percentage. jsmith 2013-11-26T16:04:13Z VT:2000006 clinical_measurement_ontology CMO:0001955 renal blood flow rate to kidney weight ratio A calculated measurement in which difference in the mean arterial blood pressure between two or more dosages of a drug or chemical which reduces the interior diameter of blood vessels is divided by difference in the logarithm of the applied dosages and presented as a ratio, fraction, quotient or percentage. The value is calculated as the slope of the curve of the mean arterial blood pressure versus log of the vasoconstrictor dose [VC] graph, given by the equation (log[VC]2 - log[VC]1)/(MAP at [VC]2 - MAP at [VC]1). A logarithm is the power to which a base, such as 10, must be raised to produce a given number. jsmith 2013-12-02T10:53:31Z clinical_measurement_ontology change in MAP to change in log[vasoconstrictor] ratio CMO:0001965 change in mean arterial blood pressure to change in the logarithm of the vasoconstrictor dose ratio Measurement of the length of a straight line passing through the center and connecting opposite points on the circumference of a circle delineating the outer limits of a glomerulosclerotic lesion. jsmith 2013-12-02T11:03:44Z clinical_measurement_ontology CMO:0001966 kidney glomerulosclerotic lesion diameter A calculated measurement in which the diameter of kidney glomerular injury is divided by the value of the mean arterial blood pressure and presented as a ratio, fraction, quotient or percentage, for example to give an index of kidney damage relative to the level of hypertension. jsmith 2013-12-02T11:54:57Z clinical_measurement_ontology CMO:0001967 kidney glomerulosclerotic lesion diameter to mean arterial blood pressure ratio Any quantification of a function of or process in the brain, one of the two components of the central nervous system. The brain is the primary center for the regulation and control of bodily activities, receiving and interpreting sensory impulses, and transmitting information to the muscles and body organs. It is also the seat of consciousness, thought, memory, and emotion. jsmith 2013-12-02T13:18:15Z EFO:0007849 MA:0000168 brain physiology measurement functional brain measurement clinical_measurement_ontology CMO:0001969 brain physiological measurement Any quantification of a morphological or physiological parameter of the central nervous system, i.e., the brain and/or spinal cord. jsmith 2013-12-02T13:23:47Z clinical_measurement_ontology CNS measurement CMO:0001970 central nervous system measurement Measurement of the physical form or structure of one or more blood vessels, the network of muscular tubes that carry blood through the body. jsmith 2013-12-03T17:32:45Z clinical_measurement_ontology CMO:0001997 blood vessel morphological measurement Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the wall of the aorta, the layered tissue which encloses and constitutes the structural component of the great artery arising from the left ventricle from which the systemic arterial system proceeds. A molecule is an aggregation of atoms, specifically a chemical combination of two or more atoms forming a specific chemical substance. jsmith 2013-12-03T18:01:02Z aortic wall molecular composition measurement clinical_measurement_ontology CMO:0001998 aorta wall molecular composition measurement The amount of elastin in a specified sample of aorta wall tissue. Elastin is an elastic, fibrous mucoprotein, similar to collagen, and the major connective tissue protein of elastic fibers, such as those in arterial walls. jsmith 2013-12-03T18:08:51Z aortic wall elastin level clinical_measurement_ontology CMO:0001999 aorta wall extracellular elastin level The amount of collagen in a specified sample of aorta wall tissue. Collagen refers to any of a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility. jsmith 2013-12-03T18:13:06Z aortic wall collagen level clinical_measurement_ontology CMO:0002000 aorta wall extracellular collagen level A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the molecules, atoms and/or ions which constitute the chemical make-up of the wall of the aorta. jsmith 2013-12-03T18:14:39Z calculated aortic wall molecular composition measurement clinical_measurement_ontology CMO:0002001 calculated aorta wall molecular composition measurement A calculated measurement in which the weight after dessication of the extracellular elastin in a specified sample of aorta wall is divided by the total weight after dessication of that sample of aorta wall, and the result presented as a ratio, fraction, quotient or percentage. jsmith 2013-12-03T18:21:20Z VT:0010568 aortic wall elastin dry weight to total aortic wall dry weight ratio clinical_measurement_ontology CMO:0002002 aorta wall extracellular elastin dry weight to aorta wall dry weight ratio A calculated measurement in which the weight after dessication of the extracellular elastin in a specified sample of aorta wall is divided by the weight of extracellular collagen in that sample of aorta wall, and the result presented as a ratio, fraction, quotient or percentage. jsmith 2013-12-03T18:29:26Z VT:0010568 aortic wall elastin dry weight to aortic wall collagen weight ratio clinical_measurement_ontology CMO:0002003 aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio The total amount of protein extracted from within the cells of the aortic wall in a specified sample of aorta. Protein is any of a group of complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages. jsmith 2013-12-04T10:31:25Z clinical_measurement_ontology aorta cellular protein level aorta wall total intracellular protein level CMO:0002004 aorta wall intracellular protein level The difference in mean arterial blood pressure between two points in time or two conditions expressed as a percentage (the proportion or rate per hundred parts). jsmith 2014-01-07T16:35:21Z VT:2000000 clinical_measurement_ontology CMO:0002035 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. percent change in mean arterial blood pressure Average slope of the line defined by the change in heart rate (the number of contractions of the cardiac ventricles per unit of time) relative to the change in mean arterial blood pressure (the average force the blood exerts on an artery wall) over time and/or in response to a change in conditions. jsmith 2014-01-07T16:51:06Z VT:2000009 baroreceptor reflex sensitivity change in HR to change in MAP ratio clinical_measurement_ontology CMO:0002036 change in heart rate to change in mean arterial blood pressure ratio Maximum, largest or steepest slope of the line defined by the change in heart rate (the number of contractions of the cardiac ventricles per unit of time) relative to the change in mean arterial blood pressure (the average blood pressure within an artery over a specified period of time) over time and/or in response to a change in conditions. jsmith 2014-01-07T16:53:44Z VT:2000009 clinical_measurement_ontology CMO:0002037 maximum change in heart rate to change in mean arterial blood pressure ratio The amount of sterol, any of a group of steroids with a long (8 to 10 carbons) aliphatic side-chain at position 17 and at least one alcoholic group, in a specified sample of blood. jsmith 2014-01-23T17:03:36Z sterol measurement EFO:0010231 clinical_measurement_ontology CMO:0002048 blood sterol level The amount of sterol, any of a group of steroids with a long (8 to 10 carbons) aliphatic side-chain at position 17 and at least one alcoholic group, in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. jsmith 2014-01-23T17:04:50Z clinical_measurement_ontology CMO:0002049 serum sterol level Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of a specified tissue or set of tissues. jsmith 2014-01-24T15:13:32Z clinical_measurement_ontology CMO:0002067 tissue molecular composition measurement Determination of the number of mononuclear cells, i.e. leukocytes such as lymphocytes and monocytes with a single round or oval nucleus (including but not limited to such cells found in blood, lymph or spleen) found in a specified sample. jsmith 2014-01-27T15:49:38Z clinical_measurement_ontology mononuclear cell number CMO:0002119 mononuclear cell count A calculated measurement in which .the number of kidney glomeruli displaying an abnormal (i.e., pathogenic) crescentic morphology is divided by the number of kidney glomeruli displaying normal morphology, and the result presented as a ratio, fraction, quotient or percentage. jsmith 2014-01-28T16:41:28Z clinical_measurement_ontology CMO:0002139 kidney crescentic glomeruli count to kidney normal glomeruli count ratio A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of heart rate, the number of contractions of the cardiac ventricles per unit of time. jsmith 2014-01-31T16:39:20Z clinical_measurement_ontology CMO:0002161 calculated heart rate measurement The difference between two points in time or two conditions in heart rate expressed as the ratio of the low frequency R-R interval component of the power spectrum analysis to the high frequency R-R interval component of the power spectrum analysis, expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. jsmith 2014-01-31T16:41:23Z absolute change in heart rate variability VT:2000009 clinical_measurement_ontology absolute change in ECG LF/HF ratio absolute change in EKG LF/HF ratio absolute change in electrocardiographic low frequency R-R interval to high frequency R-R interval ratio CMO:0002162 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the tissue(s) of the heart left ventricle. A molecule is an aggregation of atoms, specifically a chemical combination of two or more atoms forming a specific chemical substance. jsmith 2014-02-03T17:42:14Z clinical_measurement_ontology CMO:0002164 heart left ventricle molecular composition measurement The amount in a specified sample of tissue from the heart left ventricle, of natriuretic peptide A (NPPA), a powerful vasodilator and peptide hormone secreted mainly by heart muscle cells and involved in control of extracellular fluid volume and electrolyte homeostasis. jsmith 2014-02-03T17:43:11Z heart left ventricle NPPA level heart left ventricle atrial natriuretic factor level heart left ventricle natriuretic peptide A protein level clinical_measurement_ontology CMO:0002165 heart left ventricle natriuretic peptide A level The amount of renin in a specified sample of kidney tissue. Renin, an aspartyl protease, catalyzes the cleavage of angiotensinogen to form angiotensin I, the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. jsmith 2014-02-03T17:55:31Z VT:0010559 kidney renin protein level clinical_measurement_ontology kidney REN level CMO:0002166 kidney renin level Measurement of the size of the entire three dimensional space occupied by the fat inside the major body cavity or cavities of an organism, especially the fat which surrounds and cushions the internal organs. jsmith 2014-03-06T15:22:47Z VT:0010063 clinical_measurement_ontology CMO:0002183 whole body visceral fat volume Any measurement of the physical form or structure of the fat deposits in the liver of an organism. jsmith 2014-03-06T15:32:11Z EFO:0010821 liver fat measurement clinical_measurement_ontology CMO:0002187 liver fat morphological measurement Any quantification of the ability of a protein of the kidney to accomplish an effect, e.g. take part in a chemical reaction or carry out a specified molecular function. jsmith 2014-03-10T15:24:43Z clinical_measurement_ontology CMO:0002222 kidney protein activity measurement Any quantification of the ability of a kidney enzyme, i.e. a protein located in the kidney that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions, to carry out its specified molecular function. jsmith 2014-03-10T15:31:04Z clinical_measurement_ontology CMO:0002223 kidney enzyme activity measurement A calculated measurement in which the level of catalase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen. jsmith 2014-03-10T17:51:03Z VT:0010762 clinical_measurement_ontology CMO:0002224 kidney catalase activity to total protein level ratio A calculated measurement in which the level of glucose-6-phosphate dehydrogenase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Glucose-6-phosphate dehydrogenase catalizes the conversion of D-glucose 6-phosphate + NADP+ to 6-phospho-D-glucono-1,5-lactone + NADPH. jsmith 2014-03-10T17:52:00Z clinical_measurement_ontology kidney G6PD activity to total protein level ratio CMO:0002225 kidney glucose-6-phosphate dehydrogenase activity to total protein level ratio A calculated measurement in which the level of glutathione reductase (GSR) enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. GSR reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH. jsmith 2014-03-10T17:53:05Z clinical_measurement_ontology kidney GSR activity to total protein level ratio CMO:0002226 kidney glutathione reductase activity to total protein level ratio A calculated measurement in which the level of glutathione peroxidase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Glutathione peroxidases constitute a family of proteins that reduce lipid hydroperoxides to their corresponding alcohols and reduce free hydrogen peroxide to water. jsmith 2014-03-10T17:54:38Z VT:0010767 clinical_measurement_ontology CMO:0002227 kidney glutathione peroxidase activity to total protein level ratio A calculated measurement in which the level of glutathione-S-transferase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Glutathione-S-transferase refers to any of a family of proteins with the ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. jsmith 2014-03-10T17:55:21Z clinical_measurement_ontology CMO:0002228 kidney glutathione-S-transferase activity to total protein level ratio A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. superoxide dismutases constitute a family of proteins that convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. jsmith 2014-03-10T17:55:56Z VT:0010768 clinical_measurement_ontology CMO:0002229 kidney superoxide dismutase activity to total protein level ratio A calculated measurement in which the level of paraoxonase 1 enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Paraoxonase 1 is an arylesterase that mainly hydrolyzes paroxon, an organophosphorus anticholinesterase compound, to produce p-nitrophenol. jsmith 2014-03-10T17:56:39Z VT:0010770 kidney paraoxonase-1 activity to total protein level ratio clinical_measurement_ontology CMO:0002230 kidney paraoxonase1 activity to total protein level ratio A calculated measurement in which the level of glutathione peroxidase enzyme activity in a specified sample of kidney is divided by the level of glutathione reductase enzyme activity in that same sample. jsmith 2014-03-10T17:57:32Z VT:0010767 clinical_measurement_ontology CMO:0002231 kidney glutathione peroxidase activity to glutathione reductase activity ratio A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the level of catalase enzyme activity in that same sample. jsmith 2014-03-10T17:58:30Z VT:0010768 clinical_measurement_ontology CMO:0002232 kidney superoxide dismutase to catalase activity ratio A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the level of glutathione peroxidase enzyme activity in that same sample. jsmith 2014-03-10T17:59:04Z VT:0010768 clinical_measurement_ontology CMO:0002233 kidney superoxide dismutase to glutathione peroxidase ratio A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the level of paraoxonase 1 enzyme activity in that same sample. jsmith 2014-03-10T17:59:34Z VT:0010768 kidney superoxide dismutase to paraoxonase-1 activity ratio clinical_measurement_ontology CMO:0002234 kidney superoxide dismutase to paraoxonase1 activity ratio The amount of glutathione in a specified sample of kidney tissue. Glutathione (GSH/GSSG) is an antioxidant tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. jsmith 2014-03-10T18:02:47Z CHEBI:16856 VT:0010706 clinical_measurement_ontology kidney GSH level CMO:0002235 kidney glutathione level The amount of malondialdehyde in a specified sample of kidney tissue. Malondialdehyde is an organic compound with the formula CH2(CHO)2. It is a reactive species which occurs naturally, is generally found in the enol form (HOCH=CH-CHO), and is a marker for oxidative stress. jsmith 2014-03-10T18:03:40Z CHEBI:566274 VT:0010707 clinical_measurement_ontology CMO:0002236 kidney malondialdehyde level A calculated measurement in which the level of protein carbonyl (PCO) derivatives in a specified sample of kidney is divided by the total amount of protein in the sample. Protein carbonyl (PCO) derivatives are produced by the oxidation of amino acids and can be used as a marker of oxidative stress. jsmith 2014-03-10T18:04:53Z clinical_measurement_ontology CMO:0002237 kidney protein carbonyl level to total protein level ratio The amount of platinum, the chemical element with atomic number 78, in a specified sample of kidney tissue. jsmith 2014-03-10T18:06:09Z CHEBI:33364 VT:0010558 clinical_measurement_ontology CMO:0002238 kidney platinum level The amount of enzymatic activity of creatine kinase (CK) enzyme in a specified sample of serum. CK catalyses the reversible transfer of phosphate between ATP and various phosphogens such as creatine phosphate. Serum CK level is used as an enzymatic marker for myocardial infarction, rhabdomyolysis and acute renal failure. jsmith 2014-03-11T14:14:26Z VT:1000047 serum creatine phosphokinase activity level clinical_measurement_ontology serum CK activity level serum CPK activity level CMO:0002244 serum creatine kinase activity level The amount of lipid peroxidation end products in a specified sample of kidney tissue. Lipid peroxidation is the oxidative degradation of lipids. jsmith 2014-03-11T16:52:38Z VT:0010761 clinical_measurement_ontology kidney LPO level kidney lipid peroxidation level CMO:0002246 kidney lipid peroxide level A calculated estimate of the size of the three dimensional space occupied by a single kidney glomerulus. jsmith 2014-03-12T15:00:11Z PMID:16902320 PMID:19164508 VT:0005325 capillary tuft volume glomerular capillary tuft volume glomerular tuft volume glomerulus renis volume malphigian glomerulus volume clinical_measurement_ontology CMO:0002247 kidney glomerulus volume Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time, one during the day and the other at night, expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity. jsmith 2014-03-24T12:45:12Z clinical_measurement_ontology absolute circadian change in systolic blood pressure systolic diurnal amplitude CMO:0002278 The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign. absolute diurnal change in systolic blood pressure The amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, in a specified sample of blood. Cholesterol in the blood is generally associated with various lipoproteins. jsmith 2014-03-24T13:34:25Z free cholesterol measurement EFO:0008591 clinical_measurement_ontology Not4Curation CMO:0002280 blood cholesterol level The amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Cholesterol in the serum is associated with various lipoproteins. jsmith 2014-03-24T13:36:35Z clinical_measurement_ontology Not4Curation CMO:0002281 serum cholesterol level A calculated measurement in which the difference in the mean arterial blood pressure caused by two or more dosages of a drug or chemical which reduces or increases the interior diameter of blood vessels is divided by the difference of the applied dosages and presented as a ratio, fraction, quotient or percentage. The value is calculated as the slope of the curve of the mean arterial blood pressure versus the chemical dose graph. jsmith 2014-03-28T12:01:46Z VT:2000000 clinical_measurement_ontology beta coefficient of mean arterial blood pressure change change in MAP to change in [vasoactive chemical] ratio slope of the change in mean arterial blood pressure CMO:0002296 change in mean arterial blood pressure to change in vasoactive chemical dose ratio Ratio of the wall thickness (WT) of an artery to outer diameter (OD) of that artery at that location, usually expressed as a percentage, i.e. WT/OD x 100, but could also be expressed as a ratio, fraction or quotient. This measurement can be used to assess stenosis, a pathological narrowing of a blood vessel. jsmith 2014-03-28T16:44:54Z clinical_measurement_ontology arterial stenosis measurement artery wall thickness as percentage of artery outer diameter artery wall thickness as percentage of artery total diameter CMO:0002303 artery wall thickness to artery total diameter ratio Any value resulting from the quantification of a morphological or physiological parameter of leukocytes, largely colorless blood corpuscles capable of ameboid movement, whose chief function is to protect the body against microorganisms and other disease-causing entities. jsmith 2014-04-24T12:47:44Z leukocyte measurement clinical_measurement_ontology CMO:0002341 white blood cell measurement A calculated measurement in which the number of white blood cells of one or more specific types in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage. jsmith 2014-05-13T18:19:12Z clinical_measurement_ontology Not4Curation blood differential leukocyte count to total WBC count ratio blood differential leukocyte count as percentage of total white blood cells differential white blood cell percentage CMO:0002349 blood differential leukocyte count to total leukocyte count ratio Any measurement which has been normalized, adjusted or derived by a mathematical process or computation, of a morphological or physiological parameter of non-neoplastic lesions in the kidney. jsmith 2014-05-27T13:59:17Z clinical_measurement_ontology Not4Curation calculated renal non-tumorous lesion measurement CMO:0002378 calculated kidney non-tumorous lesion measurement A calculated measurement in which the area occupied by renal protein casts is divided by the total, combined area of the outer stripe of the kidney outer medulla and the kidney cortex, and the result presented as a ratio, fraction, quotient or percentage. Renal protein casts are gelled proteins precipitated in the renal tubules and molded to the tubular lumen. The medulla outer stripe is the section of the renal medula adjacent to the renal cortex and contains portions of the nephron, including the straight proximal tubules, and portions of the loops of henle and outer medullary collecting ducts. jsmith 2014-05-27T14:01:07Z VT:0010580 clinical_measurement_ontology percent area of renal protein casting CMO:0002379 ratio of the area occupied by protein casts to the total area of the kidney outer medulla outer stripe and cortex A calculated value in which the weight of the heart after removal from the body but without dessication is divided by the total weight of the body, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism. jsmith 2014-05-28T15:22:49Z VT:0007028 clinical_measurement_ontology heart wet weight as a percentage of body weight CMO:0002408 heart wet weight to body weight ratio A calculated measurement in which the difference between the contractile force of a blood vessel in response to a vasoconstrictor and the baseline contractile force exerted by that vessel in the absence of any external stimuli, is divided by the baseline contractile force measurement and the result expressed as a percentage. A vasoconstrictor is any agent or condition that narrows blood vessels by constricting the smooth muscle in the vessel walls. jsmith 2014-06-09T17:16:49Z clinical_measurement_ontology CMO:0002458 vasoconstrictor-induced blood vessel contractile force expressed as percent of force at baseline A calculated measurement in which the difference between the contractile force of a blood vessel in response to a specified dosage of phenylephrine and the baseline contractile force exerted by that vessel in the absence of any external stimuli, is divided by the baseline contractile force measurement and the result expressed as a percentage. Phenylephrine is an adrenergic drug that is a powerful vasoconstrictor. jsmith 2014-06-09T17:21:51Z VT:0005593 clinical_measurement_ontology phenylephrine-induced blood vessel constriction expressed as percent of force at baseline CMO:0002459 phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline A calculated measurement in which the difference between the contractile force of a blood vessel in response to a specified dosage of potassium chloride and the baseline contractile force exerted by that vessel in the absence of any external stimuli, is divided by the baseline contractile force measurement and the result expressed as a percentage. Potassium chloride is the salt of the potassium cation (K+) and the chlorine/chloride anion (Cl-). It is used as an eletroylyte replenisher and has mild vasoconstrictive properties when applied directly to blood vessels. jsmith 2014-06-09T17:30:04Z CHEBI:32588 VT:0005593 clinical_measurement_ontology KCl-induced blood vessel constriction expressed as percent of force at baseline CMO:0002460 potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to potassium chloride, the salt of the potassium cation (K+) and the chlorine/chloride anion (Cl-). Potassium chloride is used as an eletroylyte replenisher and has mild vasoconstrictive properties when applied directly to blood vessels. jsmith 2014-06-09T18:11:50Z CHEBI:32588 clinical_measurement_ontology KCl response/sensitivity measurement CMO:0002461 potassium chloride response/sensitivity measurement A calculated value for the concentration of potassium chloride (KCl) at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of KCl is halfway between the baseline value and the highest achievable value of such KCl-induced contractile energy. Potassium chloride is the salt of the potassium cation (K+) and the chlorine/chloride anion (Cl-). It is used as an eletroylyte replenisher and has mild vasoconstrictive properties when applied directly to blood vessels. jsmith 2014-06-09T18:19:26Z CHEBI:32588 potassium chloride half maximal effective concentration (EC50) clinical_measurement_ontology KCl half maximal effective concentration (EC50) CMO:0002462 concentration of potassium chloride at which the force of blood vessel contraction is half the maximum value (EC50) A calculated value for logarithm of the concentration of potassium chloride (KCl) at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of KCl is halfway between the baseline value and the highest achievable value of such KCl-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. jsmith 2014-06-09T18:28:02Z CHEBI:32588 KCl Log half maximal effective concentration (Log EC50) potassium chloride Log half maximal effective concentration (Log EC50) clinical_measurement_ontology CMO:0002463 logarithm of the concentration of potassium chloride at which the force of blood vessel contraction is half the maximum value (Log EC50) A calculated value for the concentration of a vasoconstrictor at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of the stimulus is halfway between the baseline value and the highest achievable value of such stimulus-induced contractile energy. A vasoconstrictor is any agent or condition that narrows blood vessels by constricting the smooth muscle in the vessel walls. jsmith 2014-06-09T18:33:14Z vasoconstrictor half maximal effective concentration (EC50) clinical_measurement_ontology CMO:0002464 concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50) A calculated value for logarithm of the concentration of a vasoconstrictor at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of the stimulus is halfway between the baseline value and the highest achievable value of such stimulus-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. A vasoconstrictor is any agent or condition that narrows blood vessels by constricting the smooth muscle in the vessel walls. jsmith 2014-06-09T18:47:36Z vasoconstrictor Log half maximal effective concentration (Log EC50) clinical_measurement_ontology CMO:0002465 logarithm of the concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (Log EC50) The quantification of any morphological or physiological parameter of one or more proteins (complex high molecular weight organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) or peptides (low molecular weight compounds composed of at least two amino acids joined by peptide linkages) in liver. jsmith 2014-06-12T13:48:50Z clinical_measurement_ontology CMO:0002478 liver protein/peptide measurement The thickness or depth of the ventral/anterior wall of the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed. The ventral/anterior wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism. jsmith 2014-06-24T10:28:27Z VT:0010491 heart left ventricle end-diastolic ventral wall thickness clinical_measurement_ontology LVAWd CMO:0002496 heart left ventricle end-diastolic anterior wall thickness A calculated measurement in which the weight of the left ventricle of the heart is divided by its area at end-diastole, that is, when the heart muscle is maximally relaxed, and the result presented as a ratio, fraction, quotient or percentage. jsmith 2014-06-24T10:38:32Z clinical_measurement_ontology CMO:0002497 heart left ventricle weight to heart left ventricle end-diastolic area ratio Any measurement of the movement of blood into, through or out of the heart. jsmith 2014-07-01T11:15:11Z clinical_measurement_ontology CMO:0002502 heart blood flow measurement Measurement of the speed at which blood flows into the ventricle during passive filling, that is, during the period when the blood flows from the atrium to the ventricle due to gravity rather than as a result of active contraction of the atrium. jsmith 2014-07-01T11:21:13Z VT:2000009 clinical_measurement_ontology CMO:0002503 E wave velocity An echocardiographic measurement of the amount of time between the maximum 'E point', that is, the maximum velocity of passive blood flow from the atrium to the ventricle, and the return to baseline at the end of early mitral flow. jsmith 2014-07-01T11:23:06Z VT:2000009 clinical_measurement_ontology DT EDT CMO:0002504 E wave deceleration time Measurement of the decrease in transmitral blood flow velocity per unit time or the rate at which the velocity of passive blood flow from the atrium to the ventricle decreases over time as the ventricle fills and the atrium empties, calculated as the slope of transmitral velocity vs time. jsmith 2014-07-01T11:26:09Z clinical_measurement_ontology EDR CMO:0002505 E wave deceleration rate Any measurement, morphological or physiological of a muscle fiber, any of the cells of skeletal or cardiac muscle tissue. Each cell is one fiber of the muscle. jsmith 2014-08-05T16:38:37Z clinical_measurement_ontology CMO:0002532 muscle fiber measurement Any measurement of the physical form or structure of a muscle fiber, any of the cells of skeletal or cardiac muscle tissue. Each cell is one fiber of the muscle. jsmith 2014-08-05T16:41:32Z clinical_measurement_ontology CMO:0002533 muscle fiber morphological measurement Any measurementof the physical form or structure of a skeletal muscle fiber, a cylindrical multinucleate cell of skeletal muscle tissue containing contracting myofibrils and across which run transverse striations. jsmith 2014-08-05T16:42:27Z OBA:2045268 muscle fiber cross-sectional area measurement clinical_measurement_ontology CMO:0002534 skeletal muscle fiber morphological measurement The average number of capillaries associated with and/or surrounding an individual skeletal muscle fiber, a cylindrical multinucleate cell of skeletal muscle tissue containing contracting myofibrils and across which run transverse striations. Capillaries are the minute vessels connecting arterioles and venules, the walls of which act as a semipermeable membrane for interchange of various substances between the blood and tissue fluid. jsmith 2014-08-05T16:43:25Z clinical_measurement_ontology number of capillaries per skeletal muscle cell CMO:0002535 number of capillaries per skeletal muscle fiber Any measurement, morphological or physiological of the minute vessels connecting arterioles and venules, the walls of which act as a semipermeable membrane for interchange of various substances between the blood and tissue fluid. jsmith 2014-08-05T16:46:26Z clinical_measurement_ontology CMO:0002536 capillary measurement The length of time in the cardiac cycle between the end of left ventricular relaxation and the start of left ventricular filling. This represents the time in the cardiac cycle between closure of the aortic valve and opening of the mitral valve. jsmith 2014-08-06T10:31:27Z VT:2000009 time constant of isovolumetric LV fall clinical_measurement_ontology LV-IVRT CMO:0002540 left ventricular isovolumetric relaxation time The time interval from the completion of the mitral valve closure to the beginning of the aortic valve opening, that is, the period of contraction during which both the mitral and aortic valves are closed so that the volume of the ventricular space doesn't change. jsmith 2014-08-06T10:46:35Z VT:2000009 clinical_measurement_ontology CMO:0002541 left ventricular isovolumetric contraction time The length of time in the cardiac cycle between the end of right ventricular relaxation and the start of right ventricular filling. jsmith 2014-08-18T11:44:51Z clinical_measurement_ontology RV-IVRT CMO:0002551 right ventricular isovolumetric relaxation time A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the length of time in the cardiac cycle between the end of left ventricular relaxation and the start of left ventricular filling. jsmith 2014-08-18T11:59:50Z clinical_measurement_ontology calculated LV-IVRT CMO:0002552 calculated left ventricular isovolumetric relaxation time A calculated measurement in which the value of the left ventricular isovolumetric relaxation time is corrected by the square root of the R-R interval [IVRT/(RR)1/2] on a simultaneously-recorded ECG. jsmith 2014-08-18T12:04:19Z clinical_measurement_ontology CMO:0002553 heart rate-corrected left ventricular isovolumetric relaxation time Measurement of the length of time between the closing of the mitral valve (the dual-flap valve in the heart that controls blood flow between the left atrium and the left ventricle) at the end of ventricular filling (that is, after atrial contraction) and its opening at the beginning of the next round of ventricular filling. jsmith 2014-08-18T12:19:05Z clinical_measurement_ontology MV co CMO:0002554 mitral valve closure to opening time The time interval from the opening to the closing of the aortic valve (mechanical systole). jsmith 2014-08-18T13:27:39Z VT:2000009 clinical_measurement_ontology LVET CMO:0002555 left ventricular ejection time A calculated measurement comprised of the sum of left ventricular isovolumetric contraction time and isovolumetric relaxation time divided by the left ventricular ejection time. jsmith 2014-08-18T13:54:20Z VT:2000009 (IVCT+IVRT)/ET LV performance index Tei Index left ventricular isovolumetric contraction time and isovolumetric relaxation time to ejection time ratio clinical_measurement_ontology MPI TEI-Doppler index CMO:0002556 myocardial performance index Any measurement of the degree to which the presentation of any cardiovascular disease state, causes pain or damage, or interferes with the normal functioning of an organism or of any part thereof. jsmith 2014-08-18T14:05:03Z clinical_measurement_ontology CMO:0002557 cardiovascular disease severity measurement Any measurement related to a deviation from or interruption of the normal structure or function of the cardiovascular system that is manifested by a characteristic set of symptoms and signs. jsmith 2014-08-18T14:20:49Z clinical_measurement_ontology CMO:0002558 cardiovascular disease measurement Any measurement of the degree to which the presentation of an arterial disease state, causes pain or damage, or interferes with the normal functioning of an organism or of any part thereof. Arterial disease is a deviation from or interruption of the normal structure or function of one or more arteries, the vessels in which blood flows away from the heart carrying oxygenated blood, that is manifested by a characteristic set of symptoms and signs. jsmith 2014-08-18T14:23:23Z clinical_measurement_ontology CMO:0002559 arterial disease severity measurement Measurement of the degree to which a tear or break in the continuity or configuration of the aorta (the great artery arising from the left ventricle and from which the systemic arterial system proceeds) causes pain or damage, or interferes with the normal functioning of an organism or of any part thereof. jsmith 2014-08-18T15:16:50Z clinical_measurement_ontology CMO:0002560 aortic rupture severity measurement The value or quantity determined by count of tears or breaks in the continuity or configuration of the fenestrated layer of elastic tissue that is the outermost part of the intima of an artery. jsmith 2014-08-18T15:33:42Z number of ruptures of internal elastic lamina in arteries number of ruptures of internal elastic laminae in arteries clinical_measurement_ontology number of RIEL in arteries number of ruptures of arterial IEL CMO:0002561 number of ruptures of arterial internal elastic lamina The value or quantity determined by count of tears or breaks in the continuity or configuration of the internal elastic lamina (IEL) of the abdominal aorta and iliac arteries, that is, the distal segment of the descending aorta and the large arteries that originate from it. jsmith 2014-08-18T15:35:18Z VT:0010639 clinical_measurement_ontology number of AA- and IA-RIEL number of RIEL in abdominal aorta and iliac arteries CMO:0002562 number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries The value or quantity determined by count of tears or breaks in the continuity or configuration of the internal elastic lamina (IEL) of the renal arteries, that is, the ateries which arise from the side of the abdominal aorta and which supply the kidneys with blood. jsmith 2014-08-18T15:47:20Z VT:0010642 clinical_measurement_ontology number of RIEL in renal arteries CMO:0002563 number of ruptures of the internal elastic lamina of the renal arteries A measurement of the severity of tears or breaks in the arterial internal elastic lamina (IEL) which is derived from a combination of multiple measurements and/or objective or subjective severity scores according to a specified formula or set of criteria. The IEL is the fenestrated layer of elastic tissue that is the outermost part of the intima of an artery. jsmith 2014-08-18T15:50:34Z VT:0010639 clinical_measurement_ontology arterial RIEL score CMO:0002564 arterial internal elastic lamina rupture composite score A calculated measurement in which the weight after dessication of the extracellular elastin in a specified sample of the wall of the aorta is divided by the length (that is, the distance between the two ends) of that segment, and the result presented as a ratio, fraction, quotient or percentage. jsmith 2014-08-18T18:42:12Z clinical_measurement_ontology CMO:0002565 aorta wall extracellular elastin dry weight to aorta length ratio A measurement of the existance and severity of a patent ductus arteriosus (PDA) when such a measurement is derived from a combination of multiple measurements and/or an objective or subjective ranking or rating system according to a specified formula or set of criteria. PDA is the abnormal persistence of an open lumen in the ductus arteriosus, between the aorta and the pulmonary artery, after birth. jsmith 2014-08-18T18:54:19Z VT:0010639 clinical_measurement_ontology PDA score score for PDA CMO:0002566 patent ductus arteriosus score Any measurement involving the composition, that is, the absolute amount, relative amount or type of one or more proteins (complex high molecular weight organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) or peptides (low molecular weight compounds composed of at least two amino acids joined by peptide linkages) in a specified tissue or set of tissues. jsmith 2014-08-26T13:32:08Z clinical_measurement_ontology CMO:0002577 tissue protein/peptide composition measurement Any measurement involving the composition, that is, the absolute amount, relative amount or type of one or more proteins or peptides in a specified sample of tissue from the wall of the aorta. jsmith 2014-08-26T13:35:55Z aortic wall protein/peptide composition measurement clinical_measurement_ontology CMO:0002579 aorta wall protein/peptide composition measurement A calculated parameter derived from a a sequence of blood pressure measurements taken sequentially and ordered in time. A parameter is a mathematical and statistical variable in a model system that partially or completely characterises the mathematical model. jsmith 2014-09-11T17:13:44Z clinical_measurement_ontology CMO:0002589 blood pressure time series calculated parameter A mathematical and statistical variable in a model system that partially or completely characterises the baroreceptor response in a blood pressure time series calculation. The baroreceptor response is the system whereby specific nerve terminals that stabilize moment to moment blood pressure variability in the carotid sinus and aortic arch sense deviations from the baseline pressure and initiate signals that dampens such deviations. jsmith 2014-09-11T18:09:25Z clinical_measurement_ontology CMO:0002590 blood pressure time series baroreceptor response calculation parameter The first order coefficient parameter derived from a blood pressure time series moving average (also known as a rolling average, running average, moving mean, or rolling mean) calculation. jsmith 2014-09-11T18:10:33Z clinical_measurement_ontology CMO:0002591 blood pressure time series first order moving average coefficient The fractal parameter derived from a blood pressure time series calculation based on a autoregressive fractionally integrated moving average time series model (ARFIMA, FARIMA, or fARIMA). jsmith 2014-09-11T18:24:22Z clinical_measurement_ontology CMO:0002592 blood pressure time series fractal parameter The experimental set point parameter of the blood pressure time series baroreceptor response calculation. jsmith 2014-09-11T18:26:20Z clinical_measurement_ontology CMO:0002593 blood pressure time series experimental set point of the baroreceptor response The average exponential scaling factor parameter of the blood pressure time series baroreceptor response calculation. jsmith 2014-09-11T18:28:14Z clinical_measurement_ontology CMO:0002594 blood pressure time series average exponential scaling factor of the baroreceptor response A parameter based on a blood pressure time series calculation using a first order mechanistic model. jsmith 2014-09-11T18:33:18Z clinical_measurement_ontology CMO:0002595 blood pressure time series linear term first order parameter A parameter based on a blood pressure time series calculation using a second order mechanistic model. jsmith 2014-09-11T18:33:53Z clinical_measurement_ontology CMO:0002596 blood pressure time series linear term second order parameter The thickness or depth (i.e. the measurement of the two-dimensional extent of the distance between the inner and outer surfaces) of the dorsal/posterior wall of the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism. jsmith 2014-10-29T10:36:08Z VT:0007087 end-diastolic heart left ventricle PWT end-diastolic heart left ventricle posterior wall thickness clinical_measurement_ontology CMO:0002597 Note that "left" in this context refers to the perspective of the organism, not that of the observer. heart left ventricle end-diastolic posterior wall thickness A value resulting from the quantification of a morphological or physiological parameter of a blood-derived lipoprotein, any of a class of complex molecules found in blood that consist of a protein membrane surrounding a core of lipids. jesmith 2015-12-03T15:18:18Z lipoprotein measurement EFO:0004732 clinical_measurement_ontology CMO:0002690 blood lipoprotein measurement Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in lipoprotein molecules in a specified volume of blood. Lipoprotein particles are complexes that consist of protein surrounding a core of lipids. jesmith 2015-12-03T15:41:10Z clinical_measurement_ontology CMO:0002696 blood lipoprotein cholesterol level The distance between the two ends, that is, of the extent of the longest dimension, of the aorta, the main trunk from which the arterial system proceeds. jesmith 2017-02-22T13:08:55Z clinical_measurement_ontology CMO:0002720 aorta length A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the physical form or structure of the aorta, the main trunk from which the arterial system proceeds. jesmith 2017-02-22T13:12:37Z clinical_measurement_ontology CMO:0002721 calculated aorta morphological measurement A calculated measurement in which the weight of the aorta is divided by its length and the resulting quantity is divided by the total body weight of the organism. jesmith 2017-02-22T13:14:54Z VT:0002845 clinical_measurement_ontology Am/AI/Bm aorta mass to aorta length to body mass ratio CMO:0002722 aorta weight to aorta length to body weight ratio A calculated measurement of the relative difference in pulse pressure between a treated state and a control state or between two points in time, expressed as a percentage. jesmith 2017-02-22T13:28:13Z clinical_measurement_ontology CMO:0002723 percent change in pulse pressure Any quantification of the ability of a protein of the heart to accomplish an effect, e.g. take part in a chemical reaction or carry out a specified molecular function. jesmith 2017-07-19T12:56:36Z clinical_measurement_ontology CMO:0002738 heart protein activity measurement Any quantification of the ability of a heart enzyme, i.e. a protein located in the heart that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions, to carry out its specified molecular function. jesmith 2017-07-19T13:02:57Z clinical_measurement_ontology CMO:0002739 heart enzyme activity level Quantitation of the catalytic effect exerted by angiotensin I converting enzyme 2 (ACE2) in a specified sample of heart tissue. ACE2, an ACE homolog, is a zinc-dependent peptidase of the M2-metalloprotease family that is sensitive to chloride ion concentration, is a membrane-bound enzyme that acts as a monocarboxypeptidase, and is an essential regulator of heart function. jesmith 2017-07-19T13:04:34Z VT:0003185 clinical_measurement_ontology heart ACE2 activity level heart angiotensin II converting enzyme activity level CMO:0002740 heart angiotensin I converting enzyme 2 activity level Quantitation of the catalytic effect exerted by angiotensin I converting enzyme (ACE) in a specified sample of heart tissue. ACE is one of the enzymes of the renin-angiotensin system, and catalyzes the conversion of angiotensin I into a physiologically active vasoconstrictor peptide angiotensin II. jesmith 2017-07-19T13:05:42Z VT:0003185 clinical_measurement_ontology heart ACE activity level CMO:0002741 heart angiotensin I converting enzyme activity level Quantitation of the catalytic effect exerted by angiotensin converting enzyme2 (ACE2) in a specified sample of kidney. ACE2, an ACE homolog, is a zinc-dependent peptidase of the M2-metalloprotease family that is sensitive to chloride ion concentration, and is a membrane-bound enzyme that acts as a monocarboxypeptidase and is an essential regulator of heart function. jesmith 2017-07-20T10:00:38Z VT:0003185 clinical_measurement_ontology kidney ACE2 activity level kidney angiotensin II converting enzyme activity level CMO:0002745 kidney angiotensin I converting enzyme 2 activity level Quantitation of the catalytic effect exerted by angiotensin I converting enzyme (ACE) in a specified sample of kidney tissue. ACE is one of the enzymes of the renin-angiotensin system, and catalyzes the conversion of angiotensin I into a physiologically active vasoconstrictor peptide angiotensin II. jesmith 2017-07-20T10:01:18Z VT:0003185 clinical_measurement_ontology kidney ACE activity level CMO:0002746 kidney angiotensin I converting enzyme activity level Any measurement of the physical form or structure of a cardiac muscle fiber, a striated cardiac muscle cell (cardiomyocyte) that is responsible for heart contraction. jesmith 2017-07-20T13:40:53Z VT:0000061 cardiac muscle cell morphological measurement cardiac myocyte morphological measurement cardiomyocyte morphological measurement heart muscle cell morphological measurement clinical_measurement_ontology cardiocyte morphological measurement CMO:0002759 cardiac muscle fiber morphological measurement The length of a straight line passing through a cardiac muscle fiber, that is a cardiomyocyte, for instance through the center of its nucleus, and connecting opposite points on its periphery. jesmith 2017-07-20T13:43:26Z VT:0000061 cardiac myocyte diameter cardiomyocyte diameter heart muscle cell diameter clinical_measurement_ontology cardiocyte diameter cardiomyocyte width CMO:0002760 cardiac muscle fiber diameter A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of plasma that perfuses the kidneys per unit time per amount of body weight. jrsmith 2018-05-03T09:34:26Z VT:0005524 clinical_measurement_ontology CMO:0002782 renal plasma flow to body weight ratio A calculated measurement in which glomerular filtration rate, an estimate of the volume of fluid filtered from the kidney glomerular capillaries into the Bowman's capsule per specified unit of time, is divided by the total weight of the body and the result is presented as a ratio, fraction, quotient or percentage. jrsmith 2018-05-03T17:41:50Z VT:0002847 clinical_measurement_ontology CMO:0002783 glomerular filtration rate to body weight ratio A calculated value in which the volume of glomeruli with lesions resulting from fibrosis, scarring or hyaline deposits is divided by the total volume of glomeruli in a specified sample of kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total volume of glomeruli. jrsmith 2018-05-11T12:56:54Z VT:0010546 clinical_measurement_ontology CMO:0002784 kidney sclerotic glomerular volume to total kidney glomerular volume ratio A calculated measurement in which the amount of hemoglobin A1c (hemoglobin glycosylated as a result of the nonenzymatic attachment of a glucose/hexose moiety) in a specified sample of blood is divided by the amount of total hemoglobin in that same sample, and the result presented as a ratio, fraction, quotient or percentage. jrsmith 2018-05-15T16:47:18Z CMO:0002902 EFO:0004541 VT:0001588 HbA1c measurement blood HbA1c level blood glycated hemoglobin level blood glycohemoglobin level blood glycosylated hemoglobin level blood hemoglobin A1c level level to blood hemoglobin level ratio clinical_measurement_ontology CMO:0002786 blood hemoglobin A1c level A calculated value in which the weight of the heart left ventricle is divided by the length of the tibia (the medial and larger of the two bones of the lower leg of bipeds or hindlimb of quadrupeds which articulates with the femur, fibula, and talus), and the result is presented as a ratio, fraction, quotient or percentage,thus normalizing it to the length of the leg and, by extension, to the size of the body. jrsmith 2018-05-15T16:59:53Z VT:0007031 LV weight/tibial length clinical_measurement_ontology CMO:0002787 heart left ventricle weight to tibia length ratio Any measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the movement of blood into, through or out of the heart. jrsmith 2018-05-15T17:02:51Z clinical_measurement_ontology CMO:0002788 calculated heart blood flow measurement A calculated measurement in which the value of the E wave (that is, the velocity of the blood flow across the mitral valve during passive filling of the left ventricle in early diastole) is divided by the value of the A wave (that is, the velocity of the blood flow across the mitral valve during active filling of the left ventricle caused by atrial contraction in late diastole). jrsmith 2018-05-15T17:05:23Z VT:2000009 clinical_measurement_ontology mitral E/A wave ratio CMO:0002789 E/A wave ratio A calculated measurement in which the average width of the tunica media is divided by the inner diameter (that is, the diameter of the lumen) of the artery and the result is presented as a ratio, fraction, quotient or percentage. jrsmith 2018-05-15T17:08:42Z clinical_measurement_ontology CMO:0002790 artery tunica media width to artery inner diameter ratio The thickness, width or depth of the septal wall of the heart ventricles (that is, the portion of the wall between the left and right ventricles that is shared between the two) at the end of diastole when the heart muscle is maximally relaxed. jrsmith 2018-05-15T17:12:15Z VT:0007086 heart interventricular end-diastolic wall thickness heart interventricular septum end-diastolic thickness clinical_measurement_ontology IVSd CMO:0002791 heart interventricular end-diastolic septal wall thickness The thickness, width or depth of the septal wall of the heart ventricles (that is, the portion of the wall between the left and right ventricles that is shared between the two) at the end of systole when the heart muscle is maximally contracted. jrsmith 2018-05-15T17:13:43Z heart interventricular end-systolic wall thickness heart interventricular septum end-systolic thickness clinical_measurement_ontology IVSs CMO:0002792 heart interventricular end-systolic septal wall thickness This is any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) found in a specified tissue. jrsmith 2018-09-28T17:35:30Z tissue RNA composition measurement tissue ribonucleic acid composition measurement EFO:0009865 VT:0011060 tissue RNA level transcriptome measurement clinical_measurement_ontology Not4Curation CMO:0002793 tissue ribonucleic acid level A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour systolic blood pressure measurements. sjwang 2018-11-13T15:00:11Z clinical_measurement_ontology CMO:0002809 systolic blood pressure variability A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour diastolic blood pressure measurements. sjwang 2018-11-13T15:02:20Z clinical_measurement_ontology CMO:0002810 diastolic blood pressure variability A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour mean arterial blood pressure measurements. sjwang 2018-11-13T15:04:28Z clinical_measurement_ontology CMO:0002811 mean arterial blood pressure variability Heart rate variability (HRV) is the physiological phenomenon of variation in the time interval between heartbeats. It is measured by the variation in the beat-to-beat interval. sjwang 2018-11-13T15:12:25Z EFO:0008003 PMID:26063669 VT:2000009 HRV RR variability cycle length variability heart rate variability measurement clinical_measurement_ontology CMO:0002812 heart rate variability A calculated value in which the number of glomeruli with microaneurysm (focal dilation of arteriocapillary junctions), is divided by the total number of glomeruli in the kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total number of glomeruli. sjwang 2018-11-14T10:49:02Z VT:0010546 clinical_measurement_ontology CMO:0002815 ratio of number of glomeruli with microaneurysms to number of total glomeruli A calculated value in which the area of glomeruli with activated mesangial cells (determined by the expression of &#945;-smooth muscle actin), is divided by the total area of glomeruli counted in the kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total number of glomeruli. sjwang 2018-11-14T11:16:40Z VT:0005325 clinical_measurement_ontology CMO:0002816 ratio of glomerular area occupied by activated mesangial cells to total glomerular area Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the glomeruli of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. sjwang 2018-11-14T11:19:47Z calculated kidney glomerulus morphological measurement clinical_measurement_ontology CMO:0002817 calculated kidney glomerulus measurement Any measurement of the physical form or structure of one or more of the mesenteric arteries, which arise from the anterior surface of the abdominal aorta, just inferior to the origin of the celiac trunk, and supplies blood to the intestine from the lower part of the duodenum through two-thirds of the transverse colon, as well as the pancreas. sjwang 2018-11-19T15:28:14Z clinical_measurement_ontology CMO:0002849 mesenteric artery morphological measurement Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the wall of one or more of the mesenteric arteries. sjwang 2018-11-19T15:30:34Z clinical_measurement_ontology CMO:0002850 mesenteric artery molecular composition measurement A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the physical form or structure of any of the mesenteric arteries. sjwang 2018-11-19T15:33:20Z calculated mesenteric artery wall molecular composition measurement clinical_measurement_ontology CMO:0002851 calculated mesenteric artery molecular composition measurement A calculated measurement in which mesenteric artery phosphorylated eNOS protein level is divided by aorta wall total eNOS protein level and presented as a ratio, fraction, quotient or percentage. Phosphorylation of eNOS is a mechanism that catylzes a structural change of the enzyme to an activated form. sjwang 2018-11-19T15:35:54Z VT:0015090 mesenteric artery phosphylated eNOS protein level to total eNOS protein level ratio mesenteric artery wall phosphylated eNOS level to total eNOS level ratio clinical_measurement_ontology CMO:0002852 mesenteric artery phosphorylated eNOS level to total eNOS level ratio A calculated measurement in which aorta wall phosphorylated eNOS protein level is divided by aorta wall total eNOS protein level and presented as a ratio, fraction, quotient or percentage. Phosphorylation of eNOS is a mechanism that catylzes a structural change of the enzyme to an activated form. sjwang 2018-11-19T15:53:29Z VT:0010946 aorta wall phosphylated eNOS protein level to total eNOS protein level ratio clinical_measurement_ontology CMO:0002853 aorta wall phosphorylated eNOS level to total eNOS level ratio Monophasic action potentials (MAPs) are recorded using contact electrode catheters. The recordings provide local information about the actual cellular depolarization and repolarization process of myocardial tissue. They are different from body surface electrocardiographic (ECG) recordings or standard endocardial electrograms, which produce a summative or derivative view of the heart's electrical activity sjwang 2018-11-26T13:03:49Z VT:2000017 clinical_measurement_ontology CMO:0002860 monophasic action potential Conduction velocity is calculated as the distance from pacing electrode to the monophasic action potential recording electrode across the epicardial surface, divided by the conduction time, the time from the pacing spike to monophasic action potential onset. sjwang 2018-11-26T13:39:11Z VT:2000017 clinical_measurement_ontology CMO:0002861 conduction velocity The E/E' is a ratio of peak velocity of early diastolic trans-mitral flow (E) to the peak velocity of early diastolic mitral annular motion (E') sjwang 2018-11-26T14:10:18Z VT:2000009 clinical_measurement_ontology E wave velocity to E' wave velocity ratio CMO:0002862 E/E' wave ratio Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the tissue(s) of the heart. sjwang 2018-11-26T14:27:05Z cardiac molecular composition measurement clinical_measurement_ontology CMO:0002863 heart molecular composition measurement Measurement of the amount of free fatty acids within the heart. sjwang 2018-11-26T14:31:33Z VT:0010046 cardiac free fatty acid level cardiac non-esterified fatty acid level heart NEFA level heart non-esterified fatty acid level clinical_measurement_ontology CMO:0002864 heart free fatty acid level Measurement of the amount of triglycerides within the heart. sjwang 2018-11-26T14:35:50Z VT:0000187 cardiac triglyceride level clinical_measurement_ontology CMO:0002865 heart triglyceride level A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the end-systolic heart left ventricle posterior wall thickness. sjwang 2018-11-26T14:44:30Z clinical_measurement_ontology CMO:0002866 calculated heart left ventricle end-systolic posterior wall thickness A calculated measurement in which the heart left ventricle end-systolic posterior wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-26T14:50:07Z VT:0002753 LVPWIs clinical_measurement_ontology CMO:0002867 heart left ventricle end-systolic posterior wall index A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart left ventricle end-systolic internal diameter. sjwang 2018-11-26T14:59:27Z calculated heart left ventricle end-systolic internal dimension clinical_measurement_ontology CMO:0002868 calculated heart left ventricle end-systolic internal diameter A calculated measurement in which the heart left ventricle end-systolic internal diameter is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-26T15:03:09Z VT:0010492 LV internal dimension index systole LVIDIs LVIDS/BW heart left ventricle end-systolic dimension to body weight ratio heart left ventricle end-systolic internal dimension index clinical_measurement_ontology LV internal dimension during systole divided by body weight CMO:0002869 heart left ventricle end-systolic diameter to body weight ratio A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart ventricle end-systolic septal wall thickness. sjwang 2018-11-26T15:08:05Z calculated heart end-systolic intraventricular wall thickness clinical_measurement_ontology CMO:0002870 calculated heart ventricle end-systolic septal wall thickness A calculated measurement in which the heart ventricle end-systolic septal wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-26T15:11:20Z VT:0007086 IVSIs interventricular septum index end-systole clinical_measurement_ontology CMO:0002871 heart ventricle end-systolic septal wall index Peak velocity of late atrial diastolic trans-mitral flow (A). sjwang 2018-11-26T15:13:54Z VT:2000009 clinical_measurement_ontology CMO:0002872 A wave velocity E' wave velocity is the peak velocity of early mitral annular diastolic motion. sjwang 2018-11-26T15:20:51Z VT:2000009 clinical_measurement_ontology CMO:0002873 E' wave velocity A' wave velocity (A') is the peak velocity of late (atrial) diastolic mitral annular motion. sjwang 2018-11-26T15:23:27Z VT:2000009 clinical_measurement_ontology CMO:0002874 A' wave velocity A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of cardiac output. sjwang 2018-11-27T15:03:00Z clinical_measurement_ontology CMO:0002880 calculated cardiac output measurement A calculated measurement in which the cardiac output is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-27T15:09:41Z VT:0010486 clinical_measurement_ontology CMO:0002881 cardiac index A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of cardiac stroke volume. sjwang 2018-11-27T15:14:24Z clinical_measurement_ontology CMO:0002882 calculated stroke volume A calculated measurement in which the cardiac stroke volume is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-27T15:16:25Z VT:0010486 clinical_measurement_ontology CMO:0002883 stroke index A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the left ventricular end-systolic blood pressure. sjwang 2018-11-27T15:20:50Z clinical_measurement_ontology CMO:0002884 calculated left ventricular end-systolic blood pressure Effective arterial elastance (Ea), defined as the ratio of left ventricular end-systolic pressure (Pes) to stroke volume (SV), provides a convenient, useful method to assess arterial load. sjwang 2018-11-27T15:23:57Z PMID:27521423 VT:0010750 E(a) Ea(PV) Pes/SV clinical_measurement_ontology CMO:0002885 arterial elastance Defined as the work performed by the left or right ventricle to eject the stroke volume into the aorta or pulmonary artery, respectively. sjwang 2018-11-27T15:29:19Z clinical_measurement_ontology CMO:0002886 ventricle stroke work Defined as the work performed by the left ventricle to eject the stroke volume into the aorta. sjwang 2018-11-27T15:32:24Z clinical_measurement_ontology CMO:0002887 left ventricle stroke work Preload recruitable stroke work (PRSW) is determined by the linear regression of stroke work with the end-diastolic volume. The slope of the PRSW relationship is a highly linear index of myocardial contractility that is insensitive to preload and afterload. sjwang 2018-11-27T15:34:52Z VT:0010486 clinical_measurement_ontology CMO:0002888 preload recruitable left ventricle stroke work A calculated measurement in which the maximum rate of positive change in left ventricular blood pressure is divided by the left ventricular end-diastolic volume, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-27T15:38:49Z VT:0010750 clinical_measurement_ontology CMO:0002889 maximum rate of positive change in left ventricular blood pressure to left ventricular end-diastolic volume ratio A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the end-diastolic heart left ventricle posterior wall thickness. sjwang 2018-11-27T15:46:13Z clinical_measurement_ontology CMO:0002890 calculated heart left ventricle end-diastolic posterior wall thickness A calculated measurement in which the heart left ventricle end-diastolic posterior wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-27T15:56:21Z VT:0007087 LVPWId clinical_measurement_ontology CMO:0002891 heart left ventricle end-diastolic posterior wall index A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart left ventricle end-diastolic anterior wall thickness. sjwang 2018-11-27T15:58:19Z clinical_measurement_ontology CMO:0002892 calculated heart left ventricle end-diastolic anterior wall thickness A calculated measurement in which the heart left ventricle end-diastolic anterior wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-27T16:14:56Z clinical_measurement_ontology CMO:0002893 heart left ventricle end-diastolic anterior wall index A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart ventricle end-diastolic septal wall thickness. sjwang 2018-11-27T16:18:07Z clinical_measurement_ontology CMO:0002894 calculated heart ventricle end-diastolic septal wall thickness A calculated measurement in which the heart ventricle end-diastolic septal wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-11-27T16:19:43Z VT:0006113 IVSId interventricular septum index end-diastole clinical_measurement_ontology CMO:0002895 heart ventricle end-diastolic septal wall index Renal medullary blood flow (MBF) is the volume of blood delivered to or exiting from the renal medulla per unit time. sjwang 2018-11-30T15:55:22Z clinical_measurement_ontology CMO:0002903 renal medullary blood flow rate Left ventricle end-diastolic elastance (Eed) is the estimate of the slope of the line Ped = Eed(Ved-V0), which is based on linear regression of points determined by iterative calculation of the LV end-diastolic pressure-volume relationship. sjwang 2018-12-03T16:21:42Z VT:0010750 Eed clinical_measurement_ontology CMO:0002909 heart left ventricle end-diastolic elastance Left ventricle end-systolic elastance (Ees) is the estimate of the slope of the line Pes = Ees(Ves-V0), which is based on linear regression of points determined by iterative calculation of the LV end-systolic pressure-volume relationship. sjwang 2018-12-03T16:24:05Z VT:0010750 Ees clinical_measurement_ontology CMO:0002910 heart left ventricle end-systolic elastance A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of components of the periodic tightening and loosening of the muscles of a ventricle of the heart. sjwang 2018-12-04T12:06:42Z clinical_measurement_ontology CMO:0002911 calculated ventricle contraction measurement Left ventricle diastolic volume-axis intercept (V0) is determined by the line Ped = Eed(Ved-V0), which is based on linear regression of points determined by iterative calculation of the LV end-diastolic pressure-volume relationship. Ped = end-diastolic pressure, Ved = end-diastolic volume, V0 – theoretical volume when no pressure is generated, Eed (end-diastolic elastance, stiffness) is the slope of the EDPVR (LV end-diastolic pressure–volume relationship). sjwang 2018-12-04T12:31:25Z PMID:12957726 VT:0007030 EDPVR V0 clinical_measurement_ontology CMO:0002912 heart left ventricle diastolic volume-axis intercept Left ventricle systolic volume-axis intercept (V0) is determined by the line Pes = Ees(Ves-V0), which is based on linear regression of points determined by iterative calculation of the LV end-diastolic pressure–volume relationship. Pes = end-systolic pressure, Ves = end-systolic volume, V0 – theoretical volume when no pressure is generated, Ees (index of LV systolic function, contractility) is the slope of the ESPVR (LV end-systolic pressure–volume relationship). sjwang 2018-12-04T12:34:18Z PMID:12957726 VT:0007030 ESPVR V0 clinical_measurement_ontology CMO:0002913 heart left ventricle systolic volume-axis intercept A measurement of the volume of blood in ventricle immediately before a contraction which has been normalized or adjusted by a mathematical process or computation. . sjwang 2018-12-04T12:46:20Z clinical_measurement_ontology CMO:0002914 calculated end-diastolic volume A measurement of the volume of blood in a ventricle at the end of a contraction which has been normalized or adjusted by a mathematical process or computation. sjwang 2018-12-04T12:59:56Z PMID:12957726 clinical_measurement_ontology CMO:0002915 calculated end-systolic volume The amount of adrenomedullin in a specified sample of kidney tissue. sjwang 2018-12-05T13:54:43Z adrenomedullin measurement EFO:0010909 clinical_measurement_ontology CMO:0002916 kidney adrenomedullin level The amount of adrenomedullin in a specified sample of medullary kidney tissue. sjwang 2018-12-05T13:57:39Z VT:0010754 clinical_measurement_ontology CMO:0002917 kidney medullary adrenomedullin level The amount of adrenomedullin in a specified sample of cortical kidney tissue. sjwang 2018-12-05T13:59:17Z VT:0010754 clinical_measurement_ontology CMO:0002918 kidney cortical adrenomedullin level Any measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the volume of fluid filtered from the kidney glomerular capillaries into the Bowman's capsule per specified unit of time based on a blood solute level, weight and age of organism and other factors. sjwang 2018-12-07T10:37:27Z EFO:0006829 VT:0002847 GFR change measurement clinical_measurement_ontology Not4Curation CMO:0002931 calculated glomerular filtration rate Any quantification of a morphological or physiological parameter of one or more nucleic acids in the heart. Nucleic acids are high-molecular-weight polymeric compounds composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose or deoxyribose sugar, and a phosphate group, and are involved in the determination and transmission of genetic characteristics. sjwang 2018-12-07T11:57:13Z clinical_measurement_ontology CMO:0002932 heart nucleic acid measurement Any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) of which the heart is formed or composed. sjwang 2018-12-07T12:02:20Z CMO:0002796 heart RNA composition measurement heart ribonucleic acid composition measurement VT:0010792 heart RNA level clinical_measurement_ontology CMO:0002933 heart ribonucleic acid level sjwang 2018-12-07T12:04:28Z VT:0010792 heart Igf1 mRNA level clinical_measurement_ontology CMO:0002934 heart insulin-like growth factor 1 mRNA level Any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) of which the heart left ventricle is formed or composed. sjwang 2018-12-07T12:09:49Z CMO:0003333 heart left ventricle ribonucleic acid composition measurement VT:0011039 heart left ventricle RNA level clinical_measurement_ontology CMO:0002935 heart left ventricle ribonucleic acid level sjwang 2018-12-07T12:23:27Z clinical_measurement_ontology CMO:0002936 heart right ventricle insulin-like growth factor 1 mRNA level This is a measurement of the amount of ribonucleic acid (RNA), the molecule composed of the sugar ribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or uracil, extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung. sjwang 2018-12-07T12:28:34Z VT:0011071 heart right ventricle RNA level heart right ventricle ribonucleic acid composition measurement clinical_measurement_ontology CMO:0002937 heart right ventricle ribonucleic acid level sjwang 2018-12-07T12:30:31Z clinical_measurement_ontology CMO:0002938 heart right ventricle molecular composition measurement sjwang 2018-12-07T12:35:54Z heart left ventricle Igf1r mRNA level clinical_measurement_ontology CMO:0002939 heart left ventricle insulin-like growth factor 1 mRNA level sjwang 2018-12-07T12:44:11Z VT:0010792 heart Igf1r mRNA level clinical_measurement_ontology CMO:0002940 heart insulin-like growth factor 1 receptor mRNA level sjwang 2018-12-07T12:46:44Z clinical_measurement_ontology CMO:0002941 heart right ventricle insulin-like growth factor 1 receptor mRNA level sjwang 2018-12-07T12:49:23Z clinical_measurement_ontology CMO:0002942 heart left ventricle insulin-like growth factor 1 receptor mRNA level Filtration fraction is the ratio of the glomerular filtration rate (GFR) to the renal plasma flow (RPF). Filtration Fraction, FF = GFR/RPF. The filtration fraction, therefore, represents the proportion of the fluid reaching the kidneys which passes into the renal tubules. sjwang 2018-12-07T14:45:56Z PMID:2846658 VT:0002847 FF filtration fraction clinical_measurement_ontology CMO:0002943 renal filtration fraction sjwang 2018-12-07T14:51:40Z VT:0002847 clinical_measurement_ontology CMO:0002944 glomerular filtration rate to kidney weight ratio A calculated measurement to determine the volume of fluid filtered from the renal (kidney) glomerular capillaries of a single nephron into Bowman's capsule per unit time. sjwang 2018-12-07T14:54:49Z VT:0002847 SNGFR clinical_measurement_ontology CMO:0002945 single nephron glomerular filtration rate A calculated measurement to determine the ratio of the single nephron glomerular filtration rate (SNGFR) to the renal plasma flow (RPF). Single nephron filtration Fraction, SNFF = SNGFR/RPF. The single nephron filtration fraction, therefore, represents the proportion of the fluid reaching the kidneys which passes into the renal tubules from a single nephron. sjwang 2018-12-07T14:57:04Z VT:0002847 SNFF clinical_measurement_ontology CMO:0002946 single nephron filtration fraction sjwang 2018-12-07T15:14:18Z clinical_measurement_ontology CMO:0002947 calculated kidney morphological measurement A semiquantitative evaluation of the renal interstitium using a grading system with a score of 0 to 4+, which assesses the tubules and the interstitium for the presence of (1) tubular atrophy, (2) tubular dilatation, (3) interstitial inflammatory cell infiltrates, and (4) interstitial fibrosis. A score of 0 indicates no lesion (normal kidney), 1+ indicates a single, small focal lesion with very minimal tubular alterations and interstitial inflammatory cell infiltration, and 2+ to 4+ indicated increasing severity of tubular lesions, interstitial inflammatory cell infiltration, and/or fibrosis. A score of 4+ indicates involvement of approximately 50% or more of the renal parenchyma or interstitium. sjwang 2018-12-07T15:16:47Z kidney tubulointerstitial score clinical_measurement_ontology Not4Curation CMO:0002948 renal tubulointerstitial score A calculated value in which the weight of the left atrium, the upper chamber on the left side of the heart which empties into the lower left chamber, is divided by the total weight of the body and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight. sjwang 2018-12-20T14:50:34Z VT:0007026 clinical_measurement_ontology CMO:0002950 heart left atrium weight to body weight ratio A measurement of the physical form or structure of the right atrium, the right upper chamber of the heart that receives blood from the vena cava and forces it into the right ventricle, which has been normalized, adjusted or derived by a mathematical process or computation. sjwang 2018-12-20T14:57:33Z clinical_measurement_ontology CMO:0002951 calculated heart right atrium morphological measurement A calculated value in which the weight of the right atrium, the upper chamber on the right side of the heart which empties into the lower right left chamber, is divided by the total weight of the body and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight. sjwang 2018-12-20T14:59:58Z VT:0007027 clinical_measurement_ontology CMO:0002952 heart right atrium weight to body weight ratio The weight of the septum of the heart, which is the portion of the heart left ventricle ventral/anterior wall and right ventricle dorsal/posterior wall which is shared between the ventricles, after removal from the body and separation from the rest of the heart. sjwang 2018-12-20T15:02:38Z VT:0006113 clinical_measurement_ontology CMO:0002953 heart septum weight The average number of podocytes in the kidney glomeruli. sjwang 2018-12-20T15:09:32Z VT:0005326 clinical_measurement_ontology CMO:0002954 number of podocytes per kidney glomerulus A calculated measurement in which the average number of podocytes is divided by the average volume of kidney glomeruli. sjwang 2018-12-20T15:13:54Z PMID:16902320 VT:0005326 clinical_measurement_ontology CMO:0002955 number of podocytes to glomerular volume ratio The average number of nucleated cells in the kidney glomeruli. sjwang 2018-12-26T16:17:20Z VT:0005325 clinical_measurement_ontology CMO:0002959 number of nucleated cells per kidney glomerulus An injury score obtained by multiplying the degree of glomerular damage (0 to 4) with the percentage of the glomeruli with that type of injury (i.e., increase in mesangial matrix material or glomerulosclerosis). sjwang 2018-12-26T16:20:07Z clinical_measurement_ontology CMO:0002960 mesangial injury score Volume of blood plasma delivered to a single glomerulus per unit time sjwang 2018-12-27T11:44:39Z PMID:2846658 VT:0005524 Qa glomerular capillary plasma flow rate initial glomerular plasma flow rate single glomerular afferent plasma flow clinical_measurement_ontology CMO:0002968 afferent arteriolar plasma flow rate Force exerted on the luminal capillary wall from fluid flowing through the capillary. sjwang 2018-12-27T11:55:22Z VT:0100012 clinical_measurement_ontology CMO:0002969 glomerular capillary hydraulic pressure Any measurement of one of the small blood vessels carrying blood between arteries and capillaries. sjwang 2018-12-27T12:03:45Z clinical_measurement_ontology CMO:0002970 arteriole measurement Resistance that must be overcome to push blood through arterioles to create flow. sjwang 2018-12-27T12:07:55Z clinical_measurement_ontology CMO:0002971 arteriolar resistance Resistance to blood flow measured within the efferent arteriole proximal to a glomerular capillary network. sjwang 2018-12-27T12:21:25Z VT:0100012 Re efferent glomerular arteriolar resistance clinical_measurement_ontology CMO:0002972 efferent arteriolar resistance Resistance to blood flow measured within the afferent arteriole distal to a glomerular capillary network. sjwang 2018-12-27T12:27:17Z VT:0100012 Ra afferent glomerular arteriolar resistance clinical_measurement_ontology CMO:0002973 afferent arteriolar resistance Total resistance to blood flow measured within the afferent arteriole proximal and distal to a glomerular capillary network (Rt = Ra + Re). sjwang 2018-12-27T12:33:35Z VT:0100012 Rt; total glomerular arteriolar resistance clinical_measurement_ontology CMO:0002974 total arteriolar resistance Measurement of the total amount of all proteins found in a specific volume of afferent arteriolar plasma. sjwang 2018-12-27T12:45:26Z VT:0005567 Ca clinical_measurement_ontology CMO:0002975 afferent arteriolar plasma protein concentration Measurement of the total amount of all proteins found in a specific volume of efferent arteriolar plasma. sjwang 2018-12-27T12:49:32Z VT:0005567 Ce clinical_measurement_ontology CMO:0002976 efferent arteriolar plasma protein concentration A form of osmotic pressure exerted by proteins, notably albumin, in the afferent arteriole's plasma that tends to pull water into the circulatory system. It is the opposing force to hydrostatic pressure. It has a major effect on the pressure across the glomerular filter. sjwang 2018-12-27T12:53:15Z VT:0010931 afferent arteriolar colloid osmotic pressure clinical_measurement_ontology CMO:0002977 afferent colloid osmotic pressure A form of osmotic pressure exerted by proteins, notably albumin, in the efferent arteriole's plasma that tends to pull water into the circulatory system. It is the opposing force to hydrostatic pressure. It has a major effect on the pressure across the glomerular filter sjwang 2018-12-27T13:07:24Z efferent arteriolar colloid osmotic pressure clinical_measurement_ontology CMO:0002978 efferent colloid osmotic pressure A measure of a membrane's permeability to water; specifically, the volume of fluid filtered in unit time through a unit area of membrane per unit pressure difference, and it is defined as the glomerular filtration rate (GFR) for both kidneys per millimeter of mercury (mmHg) of filtration pressure. sjwang 2018-12-27T13:11:50Z VT:0002847 Kf clinical_measurement_ontology CMO:0002979 glomerular capillary ultrafiltration coefficient A calculated measurement in which the area occupied by renal cysts is divided by the total the kidney, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-12-27T14:28:13Z VT:0010580 clinical_measurement_ontology CMO:0002980 ratio of the area occupied by cysts to the total area of the kidney Force exerted on the luminal surface of the proximal tubule from fluid flowing through the tubule. sjwang 2018-12-27T15:20:35Z VT:0010931 clinical_measurement_ontology CMO:0002984 mean proximal tubular hydraulic pressure Force exerted on the luminal vessel wall from fluid flowing through the efferent arteriole. sjwang 2018-12-27T15:22:41Z efferent glomerular arteriolar hydraulic pressure clinical_measurement_ontology CMO:0002985 efferent arteriolar hydraulic pressure The difference between the force exerted on the luminal glomerular capillary wall and the force exerted on the luminal proximal tubular membrane (Pgc - Pt = delta P). sjwang 2018-12-27T15:27:01Z VT:0010931 Pgc - Pt = delta P clinical_measurement_ontology CMO:0002986 glomerular transcapillary hydraulic pressure gradient sjwang 2018-12-27T15:58:18Z clinical_measurement_ontology Not4Curation CMO:0002992 calculated left ventricular end-diastolic blood pressure measurement A calculated measurement in which the pressure in the heart left ventricle at the end of diastole, the period when the heart is in a state of relaxation and expansion and the ventricles fill with blood, divided by the diameter across the left ventricle of the heart at the end of diastole and the result presented as a ratio, fraction, quotient or percentage. sjwang 2018-12-27T16:00:35Z VT:0010750 LVEDP/LVDd clinical_measurement_ontology CMO:0002993 heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio Rate-pressure product is defined as the product of the heart rate (the number of contractions of the cardiac ventricles per unit of time) (beats per minute) and mean arterial blood pressure (the average force the blood exerts on an artery wall) (mm Hg). sjwang 2019-01-02T13:36:28Z PMID:27671317 VT:2000009 RPP clinical_measurement_ontology CMO:0002994 rate-pressure product A calculated measurement of the average width of the tunica media (the middle coat of the arterial wall) divided by the artery total diameter (measured as the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the outer surface of the blood vessel wall). sjwang 2019-01-22T15:47:09Z VT:0000530 VT:0002191 VT:0011164 clinical_measurement_ontology CMO:0003013 artery tunica media to artery total diameter ratio A calculated measurement of the average width of the artery lumen (measured as the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall) divided by the artery total diameter (measured as the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the outer surface of the blood vessel wall). sjwang 2019-01-22T15:50:45Z VT:0000530 VT:0002191 VT:0011164 clinical_measurement_ontology CMO:0003014 artery lumen to artery total diameter ratio A morphological measurement of the size, volume of the outer part of the kidney, composed mainly of glomeruli and convoluted tubules. sjwang 2019-02-14T13:46:56Z VT:0000521 kidney cortex volume clinical_measurement_ontology CMO:0003027 renal cortex volume A morphological measurement of the size, volume, of the renal medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. sjwang 2019-02-14T13:52:03Z VT:0003014 kidney medulla volume clinical_measurement_ontology CMO:0003028 renal medulla volume Any measurement of the physical form or structure of platelets, the disk-shaped structures found in the blood of mammals which play a vital role in blood coagulation. Platelets lack nuclei and DNA but contain active enzymes and mitochondria. sjwang 2019-04-16T11:29:25Z clinical_measurement_ontology CMO:0003100 platelet morphological measurement A calculated measurement in which the weight of one kidney is divided by the length of tibia, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to tibia length. sjwang 2019-04-29T13:35:22Z VT:0002707 clinical_measurement_ontology CMO:0003145 single kidney weight to tibia length ratio The proportion, quantity, or volume of C-reactive protein (CRP) found in the blood. CRP is an acute phase reactant protein used to indicate inflammatory illness. It is believed to be of value in predicting coronary events. sjwang 2019-05-06T10:30:17Z EFO:0004458 C-reactive protein measurement blood CRP clinical_measurement_ontology CMO:0003160 blood C-reactive protein level The number of CD3-positive T cells in the kidney. sjwang 2019-05-08T15:54:11Z VT:0006387 clinical_measurement_ontology CMO:0003163 kidney total CD3 positive T cell count Any quantitation of the cells and/or cell types which constitute the make-up of the kidney sjwang 2019-05-08T16:01:33Z clinical_measurement_ontology CMO:0003164 kidney cellular composition measurement sjwang 2019-05-08T16:14:33Z clinical_measurement_ontology CMO:0003165 kidney total CD45 positive leukocyte count A calculated value in which the weight of the heart right ventricle is divided by the length of the tibia (the medial and larger of the two bones of the lower leg of bipeds or hindlimb of quadrupeds which articulates with the femur, fibula, and talus), and the result is presented as a ratio, fraction, quotient or percentage,thus normalizing it to the length of the leg and, by extension, to the size of the body. sjwang 2019-06-21T16:34:55Z VT:0007033 clinical_measurement_ontology CMO:0003188 heart right ventricle weight to tibia length ratio A calculated measurement in which the count of fully muscularized arterioles in a sample of lung is divided by the count of all arterioles in that sample and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the total number of arterioles. sjwang 2019-06-25T12:44:32Z lung vascular muscularization PMID:21730301 VT:0010955 clinical_measurement_ontology CMO:0003189 fully muscularized arterioles to total arterioles ratio A calculated measurement in which the count of non-muscularized arterioles in a sample of lung is divided by the count of all arterioles in that sample and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the total number of arterioles. sjwang 2019-06-25T12:46:20Z PMID:21730301 VT:0010955 clinical_measurement_ontology CMO:0003190 non-muscularized arterioles to total arterioles ratio sjwang 2019-06-25T12:49:11Z VT:0007027 clinical_measurement_ontology CMO:0003191 heart right atrium weight to left atrium weight ratio sjwang 2019-06-25T12:51:51Z VT:0007027 clinical_measurement_ontology CMO:0003192 heart right atrium weight to tibia length ratio sjwang 2019-06-25T12:55:36Z VT:0007026 clinical_measurement_ontology CMO:0003193 heart left atrium weight to tibia length ratio Left ventricle end-diastolic wall stress (LVED-WS) is a calculated measurement of the force acting against the left ventricle wall at the end of diastole, that is when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter. It is calculated by multiplying ventricular pressure by ventricular radius and dividing by 2 times the wall thickness. It is commonly referred to as the Law of Laplace. sjwang 2019-07-22T15:26:26Z VT:0010750 clinical_measurement_ontology LVED-WS CMO:0003200 left ventricle end-diastolic wall stress Left ventricle end-systolic wall stress (LVES-WS)is calculated measurement of the force acting against the left ventricle wall at the endo of end of systole, the period of contraction of the heart when the blood is forced from the ventricles into the pulmonary artery (right ventricle) and the aorta (left ventricle). It is calculated by multiplying ventricular pressure by ventricular radius and dividing by 2 times the wall thickness. Commonly referred to as Law of Laplace (PMID: 2198115) sjwang 2019-07-22T15:33:47Z VT:0010750 clinical_measurement_ontology LVES-WS CMO:0003201 left ventricle end-systolic wall stress A calculated value which compares the weight of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, with the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, and presents it as a ratio. sjwang 2019-07-24T14:40:47Z VT:0007031 clinical_measurement_ontology CMO:0003210 heart left ventricle weight to right ventricle weight ratio A calculated measurement in which the weight of the aorta is divided by the total body weight of the organism. sjwang 2019-07-25T13:38:29Z VT:0002845 clinical_measurement_ontology CMO:0003216 aorta weight to body weight ratio sjwang 2019-07-25T14:00:56Z VT:0100012 clinical_measurement_ontology CMO:0003218 renal vascular resistance to kidney weight ratio A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart left ventricle end-diastolic internal diameter. sjwang 2019-07-25T14:06:48Z Calculated heart left ventricle end-diastolic dimension clinical_measurement_ontology Calculated heart left ventricle end-diastolic internal dimension CMO:0003219 calculated heart left ventricle end-diastolic diameter A calculated measurement in which the heart left ventricle end-diastolic internal diameter is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage. Heart left ventricle end-diastolic internal dimension is the diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter. sjwang 2019-07-25T14:12:41Z VT:0010758 LV internal dimension index diastole LVIDId heart left ventricle end-diastolic dimension to body weight ratio heart left ventricle end-diastolic internal dimension index clinical_measurement_ontology CMO:0003220 heart left ventricle end-diastolic diameter to body weight ratio sjwang 2019-08-19T13:00:24Z clinical_measurement_ontology CMO:0003238 heart left ventricle infarction volume sjwang 2019-08-19T13:22:42Z clinical_measurement_ontology CMO:0003239 heart left ventricle infarction volume to total heart left ventricle volume ratio sjwang 2019-08-19T13:24:36Z clinical_measurement_ontology CMO:0003240 calculated heart left ventricle infarction volume sjwang 2019-08-19T13:43:04Z clinical_measurement_ontology CMO:0003241 calculated heart infarction volume sjwang 2019-08-19T13:49:30Z clinical_measurement_ontology Not4Curation CMO:0003242 calculated heart infarction area sjwang 2019-08-19T13:51:01Z clinical_measurement_ontology CMO:0003243 heart left ventricle infarction area to total heart left ventricle area ratio A calculated measurement in which the area of the heart left ventricle occupied by interstitial collagen is divided by the total area of the heart left ventricle, and the result presented as a ratio, fraction, quotient or percentage. sjwang 2019-10-03T15:44:41Z VT:0010747 clinical_measurement_ontology CMO:0003244 ratio of the area occupied by interstitial collagen to the total area of the heart left ventricle sjwang 2019-10-03T15:47:17Z clinical_measurement_ontology CMO:0003245 heart left ventricle angiotensin II level Angiotensin II collected from the intercellular spaces of the left ventricle myocardium. sjwang 2019-10-03T15:49:43Z CMO:0003202 heart left ventricle myocardium interstitial angiotensin II level clinical_measurement_ontology CMO:0003246 heart left ventricle interstitial angiotensin II level sjwang 2019-10-03T15:52:16Z clinical_measurement_ontology CMO:0003247 heart left ventricle bradykinin level The amount of bradykinin found in the intercellular spaces of the myocardium. sjwang 2019-10-03T15:53:55Z CMO:0003203 heart left ventricle myocardial interstitial bradykinin level myocardial interstitial bradykinin level clinical_measurement_ontology CMO:0003248 heart left ventricle interstitial bradykinin level Epinephrine collected from the intercellular spaces of the left ventricle myocardium. sjwang 2019-10-03T16:10:29Z CMO:0003205 heart left ventricle interstitial adrenaline level heart left ventricle myocardium interstitial epinephrine level clinical_measurement_ontology CMO:0003249 heart left ventricle interstitial epinephrine level Norepinephrine collected from the intercellular spaces of the left ventricle myocardium. sjwang 2019-10-03T16:12:58Z CMO:0003204 heart left ventricle interstitial noradrenaline level heart left ventricle myocardium interstitial norepinephrine level clinical_measurement_ontology CMO:0003250 heart left ventricle interstitial norepinephrine level A calculated value which compares the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, with the weight of the left ventricle (including the ventricular septum), the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, and presents it as a ratio. slaulede 2019-12-09T15:21:48Z VT:0007033 Ratio of RV weight to LV+S weight clinical_measurement_ontology CMO:0003280 heart right ventricle weight to left ventricle plus septum weight ratio Measurement of the pressure within the heart right ventricle at the end of systole, the period of contraction of the heart when the blood is forced from the ventricles into the pulmonary artery (right ventricle) and the aorta (left ventricle). slaulede 2019-12-09T16:33:26Z VT:0010892 clinical_measurement_ontology CMO:0003281 right ventricular end-systolic blood pressure Measurement of the pressure within the heart right ventricle at the point of maximal contraction, when the blood is forced from the right ventricle into the pulmonary artery. slaulede 2019-12-09T16:36:49Z clinical_measurement_ontology CMO:0003282 right ventricular systolic blood pressure The minimum pressure in the heart right ventricle, usually at the point at which the heart is in a state of relaxation and expansion and the ventricles fill with blood. slaulede 2019-12-09T16:43:40Z clinical_measurement_ontology CMO:0003283 right ventricular diastolic blood pressure The pressure in the heart right ventricle at the end of diastole, the period when the heart is in a state of relaxation and expansion and the ventricles fill with blood. slaulede 2019-12-09T16:47:48Z clinical_measurement_ontology CMO:0003284 right ventricular end-diastolic blood pressure The average pressure (geometric mean) during the aortic pulse cycle. slaulede 2019-12-09T17:52:40Z VT:2000000 clinical_measurement_ontology CMO:0003285 mean aortic pressure This is a calculated measurement in which the maximum rate of positive change in left ventricular blood pressure in a subject is divided by the left ventricular systolic blood pressure in that subject and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the left ventricular systolic blood pressure. sjwang 2019-12-18T14:15:28Z VT:0010750 LVdP/dtmax/P clinical_measurement_ontology CMO:0003287 maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio A calculated measurement that is used as an index to characterize the contractile ability of the heart. sjwang 2019-12-20T11:25:47Z VT:0010750 LVdP/dtmin clinical_measurement_ontology CMO:0003288 minimum rate of positive change in left ventricular blood pressure hsnalabolu 2020-01-10T15:31:08Z right renal cortex ribonucleic acid composition measurement right renal cortex RNA level clinical_measurement_ontology CMO:0003289 right renal cortex ribonucleic acid level hsnalabolu 2020-01-10T15:31:08Z right renal pelvis ribonucleic acid composition measurement right renal pelvis RNA level clinical_measurement_ontology CMO:0003291 right renal pelvis ribonucleic acid level hsnalabolu 2020-01-10T15:31:08Z renal pelvis ribonucleic acid composition measurement renal pelvis RNA level clinical_measurement_ontology CMO:0003296 renal pelvis ribonucleic acid level hsnalabolu 2020-01-10T15:31:08Z left renal pelvis ribonucleic acid composition measurement left renal pelvis RNA level clinical_measurement_ontology CMO:0003297 left renal pelvis ribonucleic acid level hsnalabolu 2020-01-13T09:03:17Z mitral valve ribonucleic acid composition measurement mitral valve RNA level clinical_measurement_ontology CMO:0003301 mitral valve ribonucleic acid level hsnalabolu 2020-01-13T09:03:17Z VT:0011111 heart left atrium ribonucleic acid composition measurement left cardiac atrium ribonucleic acid composition measurement left cardiac atrium ribonucleic acid level clinical_measurement_ontology CMO:0003324 heart left atrium ribonucleic acid level hsnalabolu 2020-01-13T09:03:17Z tricuspid valve ribonucleic acid composition measurement tricuspid valve RNA level clinical_measurement_ontology CMO:0003329 tricuspid valve ribonucleic acid level The diameter across the inside of the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter. sjwang 2020-01-28T10:09:41Z LVIDd heart left ventricular end-diastolic internal diameter left ventricular internal dimension at diastole clinical_measurement_ontology CMO:0003376 heart left ventricle end-diastolic internal diameter A measurement of the amount of angiotensin II type 1 receptor, the angiotensin receptor exhibiting vasopressor effects, regulation of aldosterone secretion and blood pressure and volume control, in a specified sample of glomerular tissue expressed relative to the weight of total protein in that sample. sjwang 2020-01-28T10:18:51Z clinical_measurement_ontology CMO:0003377 glomerular angiotensin II type 1 receptor density A calculated measurement in which the weight after removal from the body but without desiccation of the weight of one or both kidneys, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a ratio, percentage, fraction or quotient, thus normalizing it to body weight. slaulede 2020-04-07T16:55:45Z VT:0002707 kidney wet weight as percentage of body weight clinical_measurement_ontology CMO:0003389 kidney wet weight to body weight ratio The weight of the lower left chamber of the heart (including the ventricular septum), which pumps oxygenated blood through the aorta into the systemic arteries, after removal from the body and separation from the rest of the heart but without desiccation. slaulede 2020-04-21T17:25:17Z LV+S wet weight clinical_measurement_ontology CMO:0003400 heart left ventricle plus septum wet weight The width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of Bowman's capsule. slaulede 2020-05-04T12:26:09Z MP:0011409 VT:0005325 renal glomerulus basement membrane thickness clinical_measurement_ontology CMO:0003401 kidney glomerulus basement membrane thickness A calculated value made by dividing the mesangial fraction volume by the total glomerular volume, both values having been calculated from measurements of microscopic images. slaulede 2020-05-04T14:39:47Z CMO:0003403 Vmes PMID:14993490 PMID:3226452 VT:0005325 kidney fractional mesangial volume kidney mesangium volume to glomerulus volume ratio mesangial Vv mesangial volume density (Vv) ratio of glomerular area occupied by mesangial cells to total glomerular area renal mesangium volume to glomerulus volume ratio clinical_measurement_ontology CMO:0003402 mesangium volume to glomerulus volume ratio Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to carbachol, the ammonium salt that is a slowly hydrolyzed cholinergic agonist that acts at both muscarinic receptors and nicotinic receptors. slaulede 2020-05-12T17:08:10Z CHEBI:3385 MESH:D002217 carbamylcholine response/sensitivity measurement carbastat response/sensitivity measurement carboptic response/sensitivity measurement clinical_measurement_ontology CMO:0003408 carbachol response/sensitivity measurement A calculated value for the concentration of carbachol, the ammonium salt that is a slowly hydrolyzed cholinergic agonist that acts at both muscarinic receptors and nicotinic receptors, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of carbachol is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during carbachol-induced relaxation of the vessel wall (i.e. the maximum effect of carbachol which is the minimum contractile energy). slaulede 2020-05-12T17:18:33Z CHEBI:3385 MESH:D002217 VT:0000197 concentration of carbamylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) concentration of carbastat at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) clinical_measurement_ontology CMO:0003409 concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) This is a measure of the relaxation caused by the addition of carbachol to a pre-constricted blood vessel. It is the ratio of the amount of dilation compared to a fully dilated blood vessel. slaulede 2020-05-12T17:33:55Z CHEBI:3385 MESH:D002217 PMID:22783192 VT:0000197 clinical_measurement_ontology carbachol-induced blood vessel dilation expressed as percent of phenylephrine-induced vasoconstriction CMO:0003410 carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to BAY60-4552, a chemical that belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase. slaulede 2020-05-15T12:28:44Z PMID:22783192 Nelociguat response/sensitivity measurement clinical_measurement_ontology CMO:0003411 BAY60-4552 response/sensitivity measurement This is a measure of the relaxation caused by the addition of BAY 60-4552 to a pre-constricted blood vessel. It is the ratio of the amount of dilation compared to a fully dilated blood vessel. slaulede 2020-05-15T12:45:58Z PMID:22783192 VT:0000197 Nelociguat-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel clinical_measurement_ontology CMO:0003412 BAY 60-4552-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel A calculated value for the concentration of BAY 60-4552, a small molecule stimulator of soluble guanylate cyclase, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of BAY 60-4552 is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during BAY 60-4552-induced relaxation of the vessel wall (i.e. the maximum effect of BAY 60-4552 which is the minimum contractile energy). slaulede 2020-05-15T13:02:00Z PMID:22783192 VT:0000197 concentration of Nelociguat at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) clinical_measurement_ontology CMO:0003413 concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to GSK2181236A, a chemical that belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase. slaulede 2020-05-19T15:49:44Z PMID:22783192 1-(6-{2-[({3-methyl-4 -[(trifluoromethyl)oxy]-4-biphenylyl}methyl)oxy] phenyl}-2-pyridinyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid response/sensitivity measurement clinical_measurement_ontology CMO:0003414 GSK2181236A response/sensitivity measurement This is a measure of the relaxation caused by the addition of GSK2181236A to a pre-constricted blood vessel. It is the ratio of the amount of dilation compared to a fully dilated blood vessel. slaulede 2020-05-19T15:55:34Z PMID:22783192 VT:0000197 clinical_measurement_ontology GSK2181236A-induced blood vessel dilation expressed as percent of phenylephrine-induced vasoconstriction CMO:0003415 GSK2181236A-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel A calculated value for the concentration of GSK2181236A, a small molecule activator of soluble guanylate cyclase, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of GSK2181236A is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during GSK2181236A-induced relaxation of the vessel wall (i.e. the maximum effect of GSK2181236A which is the minimum contractile energy). slaulede 2020-05-19T16:00:44Z PMID:22783192 VT:0000197 clinical_measurement_ontology CMO:0003416 concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) In the physiology of the kidney, free water clearance is the volume of blood plasma that is cleared of solute-free water per unit time. A free water clearance of zero means the kidney is producing urine isotonic with respect to the plasma. Values greater than zero for free water clearance imply that the kidney is producing dilute urine through the excretion of solute-free water. slaulede 2020-05-28T14:54:46Z PMID:23955305 clinical_measurement_ontology renal water clearance CMO:0003418 free water clearance Any measurement relating to the function of the kidney or any part thereof. The kidney functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. slaulede 2020-05-28T14:59:47Z renal physiological measurement clinical_measurement_ontology CMO:0003419 kidney physiological measurement A measurement of kidney function which has been normalized, adjusted or derived by a mathematical process or computation. slaulede 2020-05-28T15:50:19Z EFO:0006836 calculated renal physiological measurement clinical_measurement_ontology rapid kidney function decline CMO:0003420 calculated kidney physiological measurement A calculated measurement in which the value for free water clearance is divided by the total body weight of the organism and presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight. slaulede 2020-05-28T15:56:24Z kidney water reabsorption level to body weight ratio nephron water absorption level to body weight ratio renal water absorption level to body weight ratio renal water reabsorption level to body weight ratio clinical_measurement_ontology CMO:0003421 free water clearance level to body weight ratio The amount of hyaluronic acid, a mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits found in the connective tissues of vertebrates, found in a specified sample of kidney tissue. slaulede 2020-05-28T17:55:06Z CHEBI:16336 kidney hyaluronan level renal hyaluronan level renal hyaluronic acid level clinical_measurement_ontology CMO:0003422 kidney hyaluronic acid level Any measurement that has been normalized, adjusted or derived by a mathematical process or computation of enzyme activity in a specified sample of kidney. slaulede 2020-05-28T18:30:26Z calculated renal enzyme activity measurement clinical_measurement_ontology CMO:0003423 calculated kidney enzyme activity measurement A calculated measurement in which the level of hyaluronidase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Hyaluronidase is a term applied to a group of very dissimilar enzymes that degrade hyaluronan (HA, hyaluronic acid), a high-molecular-weight glycosaminoglycan of the extracellular matrix. slaulede 2020-06-02T15:42:19Z ISBN:978-1-59259-209-8 renal hyaluronidase activity to total protein level ratio clinical_measurement_ontology CMO:0003424 kidney hyaluronidase activity to total protein level ratio Measurement of the amount of any xenobiotic or metabolic kinetics in a specified sample of kidney. A xenobiotic is a chemical compound foreign to a given biologic system, or more specifically, a pharmacologically, endocrinologically, or toxicologically active substance not endogenously produced and therefore foreign to an organism. slaulede 2020-06-08T17:23:33Z kidney uptake of xenobiotic clinical_measurement_ontology CMO:0003438 renal uptake of xenobiotic Measurement of the amount of a gadolinium-based contrast agent or metabolic kinetics in a specified sample of kidney. Gadolinium-Based Contrast Agents (GBCA) are intravenous drugs used in diagnostic imaging procedures to enhance the quality of magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA). slaulede 2020-06-08T17:32:25Z renal uptake of GBCA clinical_measurement_ontology CMO:0003439 renal uptake of gadolinium-based contrast agent Measurement of the the time elapsed between intravenous injection of Gd-DTPA (gadopentetate dimeglumine) and highest concentration of Gd-DTPA in the kidney cortex. slaulede 2020-06-08T17:45:59Z CHEBI:31797 VT:0010638 renal perfusion index time to peak measurement of gadopentetate dimeglumine uptake by kidney cortex clinical_measurement_ontology CMO:0003440 time to peak measurement of Gd-DTPA uptake by kidney cortex The total number of microscopic instances of kidney tubule regenerative structures observed in a diseased kidney. slaulede 2020-06-09T18:15:26Z VT:0010580 renal tubule regeneration foci count renal tubule regeneration foci number clinical_measurement_ontology CMO:0003443 kidney tubule regeneration foci count The total number of microscopically detected kidney tubule casts observed in a kidney.Renal intratubular casts may be hyaline or granular and observed in a number of renal diseases. Commonly observed hyaline (eosinophilic, homogeneous, proteinaceous) casts are associated with increased glomerular permeability such as with chronic progressive nephropathy and granular (necrotic cellular debris) casts are indicative of previous tubule cell necrosis. slaulede 2020-06-11T14:12:46Z PMID:11682445 VT:0010580 https://ntp.niehs.nih.gov kidney total tubular cast count renal total tubule cast count total intratubular cast count clinical_measurement_ontology CMO:0003444 kidney total tubule cast count The total number of microscopic instances of inflammation of the interstitial tissue of the kidney. The term interstitial tissue of the kidney is generally used for primary inflammation of kidney tubules and/or surrounding interstitium. slaulede 2020-06-11T14:37:11Z MESH:D009395 VT:0010580 foci of tubulointerstitial nephritis clinical_measurement_ontology CMO:0003445 interstitial nephritis foci count The total number of microscopic instances of fibrosis observed in a diseased kidney. Renal fibrosis is the consequence of excessive accumulation of extracellular matrix and represents a failed wound-healing process of the kidney tissue. slaulede 2020-06-11T15:33:20Z VT:0010580 kidney fibrosis foci count clinical_measurement_ontology CMO:0003446 renal fibrosis foci count The total number of microscopic instances of glomerular injury observed in a diseased kidney. The spectrum of glomerular lesions can be focal (only in some glomeruli), diffuse (in all or almost all the glomeruli), segmental (only a part of the glomerulus), or global (the entire glomerulus). slaulede 2020-06-11T16:00:33Z PMID:11682445 VT:0010546 renal glomerular lesion count clinical_measurement_ontology CMO:0003447 kidney glomerular lesion count The amount in a specified sample of tissue from the heart left ventricle, of epinephrine, a catecholamine which can act as a neurotransmitter, a stress hormone, a stimulator of the sympathetic nervous system and a vasoconstrictor. slaulede 2020-06-25T15:35:37Z ISBN:978-1416049982 heart left ventricle adrenaline level clinical_measurement_ontology CMO:0003469 heart left ventricle epinephrine level The amount in a specified sample of tissue from the heart left ventricle, of norepinephrine, a catecholamine neurotransmitter and stress hormone with multiple physiological roles including affects on heart rate, blood pressure and vascular tone. slaulede 2020-06-25T15:43:54Z ISBN:978-1416049982 XCO:0000127 heart left ventricle noradrenaline level clinical_measurement_ontology CMO:0003470 heart left ventricle norepinephrine level A calculated measurement in which the heart left ventricle end-diastolic internal diameter is divided by the posterior wall thickness, and the result presented as a ratio, fraction, quotient or percentage. Heart left ventricle end-diastolic internal dimension is the diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter. slaulede 2020-06-25T17:26:40Z PMID:22768235 VT:0010758 clinical_measurement_ontology CMO:0003471 heart left ventricle end-diastolic diameter to posterior wall thickness ratio Any measurement of an inorganic element or compound containing a metal, nonmetal, radical, or phosphate that is needed for proper body function and maintenance of health, in kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. slaulede 2020-06-26T14:19:28Z renal mineral measurement clinical_measurement_ontology CMO:0003472 kidney mineral measurement Any measurement of copper, an essential dietary trace element, atomic number 29, involved in the formation of bone and blood as a necessary component of several enzymes, in kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. slaulede 2020-06-26T14:23:28Z renal copper measurement clinical_measurement_ontology CMO:0003473 kidney copper measurement Measurement of the weight or heaviness of the copper, an essential dietary trace element, atomic number 29, involved in the formation of bone and blood as a necessary component of several enzymes, in a specified sample of kidney. slaulede 2020-06-26T14:36:40Z ISBN:978-1416049982 renal copper weight clinical_measurement_ontology CMO:0003474 kidney copper weight Measurement of the total weight or heaviness of the copper, an essential dietary trace element, atomic number 29, involved in the formation of bone and blood as a necessary component of several enzymes, in one or both kidneys. slaulede 2020-06-26T14:40:55Z ISBN:978-1416049982 renal total copper weight clinical_measurement_ontology CMO:0003475 kidney total copper weight A measurement of the weight or heaviness of the copper in a specified sample of kidney, when that measurement has been normalized, adjusted or derived by a mathematical process or computation. slaulede 2020-06-26T14:45:47Z calculated renal copper weight clinical_measurement_ontology CMO:0003476 calculated kidney copper weight A calculated measurement in which the weight of copper in a specified sample of kidney is divided by the total weight of the body of the organism and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the size of the organism. slaulede 2020-06-26T14:48:58Z ISBN:978-1416049982 renal copper weight to body weight ratio clinical_measurement_ontology CMO:0003477 kidney copper weight to body weight ratio A calculated measurement in which the weight of copper in a specified sample of kidney is divided by the dry weight of that kidney sample, that is, the weight of the sample after dessication, and presented as a ratio, fraction, quotient or percentage. slaulede 2020-06-26T15:12:08Z ISBN:978-1416049982 renal copper weight to renal dry weight ratio clinical_measurement_ontology CMO:0003478 kidney copper weight to kidney dry weight ratio A calculated measurement in which the weight of copper in a specified sample of kidney is divided by the weight of that kidney sample and presented as a ratio, fraction, quotient or percentage. slaulede 2020-06-26T15:17:16Z ISBN:978-1416049982 renal copper weight to renal weight ratio clinical_measurement_ontology CMO:0003479 kidney copper weight to kidney weight ratio A calculated measurement in which the weight of copper in a specified sample of kidney is divided by the wet weight of that kidney sample, that is, the weight of the sample after removal from the body but without dessication, and presented as a ratio, fraction, quotient or percentage slaulede 2020-06-26T15:21:32Z ISBN:978-1416049982 renal copper weight to renal wet weight ratio clinical_measurement_ontology CMO:0003480 kidney copper weight to kidney wet weight ratio The amount of bradykinin collected from the intercellular spaces of the left ventricle myocardium over a designated period of time. slaulede 2020-06-29T13:56:36Z CHEBI:3165 MESH:D001920 VT:0010813 clinical_measurement_ontology CMO:0003481 heart left ventricle interstitial bradykinin level during a period of time The amount of angiotensin II in the heart left ventricle interstitium measured over a designated period of time. Ang II is considered to be the main effector of the renin-angiotensin system (RAS), has endocrine, autocrine/paracrine, and intracrine hormone activities in the body and acts as a powerful vasoconstrictor. slaulede 2020-06-29T14:03:57Z CHEBI:48432 MESH:D000804 VT:0010814 clinical_measurement_ontology CMO:0003482 heart left ventricle interstitial angiotensin II level during a period of time The amount of epinephrine collected from the intercellular spaces of the left ventricle myocardium over a designated period of time. slaulede 2020-06-29T14:17:10Z VT:0010811 heart left ventricle interstitial adrenaline level during a period of time heart left ventricle myocardium interstitial epinephrine level during a period of time clinical_measurement_ontology CMO:0003483 heart left ventricle interstitial epinephrine level during a period of time The amount of norepinephrine collected from the intercellular spaces of the left ventricle myocardium over a designated period of time. slaulede 2020-06-29T14:44:13Z VT:0010812 XCO:0000127 heart left ventricle interstitial noradrenaline level during a period of time heart left ventricle myocardium interstitial norepinephrine level during a period of time clinical_measurement_ontology CMO:0003484 heart left ventricle interstitial norepinephrine level during a period of time The measurement of the total glomerular surface area as delimited by the internal edge of Bowman's capsule. slaulede 2020-07-07T17:17:47Z PMID:12827026 VT:0010925 kidney glomerulus surface area clinical_measurement_ontology CMO:0003488 kidney glomerular surface area The tuft surface area is defined as the total glomerular surface area minus the urinary space area and the urinary recesses. slaulede 2020-07-07T17:24:08Z PMID:12827026 VT:0010925 clinical_measurement_ontology CMO:0003489 kidney glomerular tuft surface area The number of individuals in a study population which develop new instances of renal vascular pathology during a period of time compared to the total number of individuals in the study population, expressed as a percentage. slaulede 2020-07-24T16:17:10Z ISBN:978-1416049982 VT:0010580 renal vascular pathology incidence clinical_measurement_ontology CMO:0003504 percentage of study population developing renal vascular pathology during a period of time In the physiology of the kidney, free water reabsorption is the volume of water reabsorbed by the blood plasma from the kidney per unit time. A free water reabsorption of zero means the kidney is producing urine isotonic with respect to the plasma. Values greater than zero for free water reabsorption imply that the kidney is producing concentrated urine through the excretion of water with a high level of solutes. slaulede 2020-12-17T17:58:15Z PMID:23955305 kidney water reabsorption nephron water absorption renal water absorption renal water reabsorption clinical_measurement_ontology CMO:0003615 free water reabsorption A calculated measurement in which the value for free water reabsorption is divided by the total body weight of the organism and presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight. slaulede 2020-12-18T11:13:57Z PMID:23955305 VT:0003620 clinical_measurement_ontology CMO:0003616 free water reabsorption level to body weight ratio The amount of hyaluronic acid, a mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits found in the connective tissues of vertebrates, found in a specified sample of kidney cortex tissue. slaulede 2020-12-18T11:28:46Z CHEBI:16336 PMID:23955305 VT:0010558 renal cortex hyaluronic acid level clinical_measurement_ontology CMO:0003617 kidney cortex hyaluronic acid level The amount of hyaluronic acid, a mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits found in the connective tissues of vertebrates, found in a specified sample of kidney papillary tissue. slaulede 2020-12-18T11:45:56Z CHEBI:16336 PMID:23955305 VT:0010558 renal papilla hyaluronic acid level clinical_measurement_ontology CMO:0003618 kidney papilla hyaluronic acid level Measurement of the physical form or structure of one or more nephrons in the kidney. A nephron is made up of a glomerulus, Bowman's capsule, proximal convoluted tubule, loop of Henle, distal convoluted tubule, collecting tubule, and collecting duct. A nephron is the basic functional unit of the kidney and its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. slaulede 2020-12-18T17:12:36Z clinical_measurement_ontology CMO:0003619 nephron morphological measurement The total number of nephrons in a kidney. A nephron is made up of a glomerulus, Bowman's capsule, proximal convoluted tubule, loop of Henle, distal convoluted tubule, collecting tubule, and collecting duct. A nephron is the basic functional unit of the kidney and its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. slaulede 2020-12-18T17:34:00Z VT:0003881 nephron number total number of nephrons clinical_measurement_ontology CMO:0003620 nephron count A calculated measurement in which the level of hyaluronidase enzyme activity in a specified sample of kidney cortex is divided by the weight of total protein in that sample. Hyaluronidase is a term applied to a group of very dissimilar enzymes that degrade hyaluronan (HA, hyaluronic acid), a high-molecular-weight glycosaminoglycan of the extracellular matrix. slaulede 2020-12-22T18:32:37Z ISBN:978-1-59259-209-8 PMID:23955305 VT:0010558 renal cortex hyaluronidase activity to total protein level ratio clinical_measurement_ontology CMO:0003621 kidney cortex hyaluronidase activity to total protein level ratio A calculated measurement in which the level of hyaluronidase enzyme activity in a specified sample of kidney papillary tissue is divided by the weight of total protein in that sample. Hyaluronidase is a term applied to a group of very dissimilar enzymes that degrade hyaluronan (HA, hyaluronic acid), a high-molecular-weight glycosaminoglycan of the extracellular matrix. slaulede 2020-12-22T18:37:43Z ISBN:978-1-59259-209-8 PMID:23955305 VT:0010558 renal papilla hyaluronidase activity to total protein level ratio clinical_measurement_ontology CMO:0003622 kidney papilla hyaluronidase activity to total protein level ratio The average length of a line which crosses a transverse view of the left anterior descending artery, one of the two branches of the left coronary artery, passing through its center and ending on either side at the outer surface of the blood vessel wall. slaulede 2021-01-04T15:26:49Z PMID:22508433 AIV external diameter LAD artery outer diameter anterior interventricular artery external diameter left anterior descending artery external diameter clinical_measurement_ontology CMO:0003623 left anterior descending artery outer diameter The average length of a line which crosses a transverse view of a coronary septal artery, a branch of the left anterior descending artery that supplies blood to the interventricular septum of the heart, passing through its center and ending on either side at the outer surface of the blood vessel wall. slaulede 2021-01-04T15:36:47Z PMID:22508433 coronary septal perforator external diameter coronary septal perforator outer diameter clinical_measurement_ontology CMO:0003624 coronary septal artery outer diameter The length of a line which crosses a transverse view of a middle cerebral artery, passing through its center and ending on either side at the outer surface of the blood vessel wall. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain. slaulede 2021-01-04T17:10:09Z PMID:22508433 VT:0010921 MCA external diameter MCA outer diameter middle cerebral artery external diameter clinical_measurement_ontology CMO:0003625 middle cerebral artery outer diameter This index is the first order rate constant, k(cl), which describes the clearance of an extracellular contrast agent (Gd-DTPA (gadopentetic acid), Gd-DOTA (gadoteric acid), or gadoterate meglumine (organoammonium salt of gadoteric acid) from renal cortex to outer medulla as calculated according to the following equation: k(cl)=(dc[medulla]/dt)/c[cortex]. The concentration in the cortex (predominantly blood signal) is compared to the concentration in the medulla (predominantly urine). The clearance of the contrast agent can serve as a marker for the glomerular filtration rate. slaulede 2021-01-07T13:50:01Z PMID:10913720 PMID:14561850 K(cl) clinical_measurement_ontology CMO:0003628 glomerular filtration rate index The concentration of a contrast agent in the cortex (predominantly blood signal) from multiple areas of both kidneys is compared to the concentration in multiple areas of the medulla (predominantly urine) of both kidneys to obtain the first order rate constant, k(cl). The clearance of the contrast agent can serve as a marker for the glomerular filtration rate. slaulede 2021-01-07T18:35:31Z PMID:14561850 VT:0002847 multi-regional GFR multi-regional K(cl) clinical_measurement_ontology CMO:0003631 multiregional glomerular filtration rate index The concentration of a contrast agent in the cortex (predominantly blood signal) from limited areas of one kidney is compared to the concentration in limited areas of the medulla (predominantly urine) of the same kidney to obtain the first order rate constant, k(cl). The clearance of the contrast agent can serve as a marker for the glomerular filtration rate. slaulede 2021-01-07T18:50:18Z PMID:14561850 regional GFR regional K(cl) clinical_measurement_ontology CMO:0003632 regional glomerular filtration rate index This is a calculated measurement of the ability of the kidney glomerulus to keep albumin out of the urine by its filtering function. It is the ratio of the albumin concentration in the filtrate (in Bowman’s space) to the albumin concentration in the plasma (in the glomerular capillaries). The equation to derive this sieving value is based on fluorescence values from intravital multiphoton microscopy: (intensity of Bowman’s space – intensity of background Bowman’s space)/(intensity of capillaries – intensity of background capillaries). slaulede 2021-01-15T11:18:28Z PMID:25680709 VT:0002847 GSCA clinical_measurement_ontology CMO:0003635 glomerular sieving coefficient for albumin A microscopic measure of the amount of albumin reabsorbed by the proximal tubule per area of proximal tubule, where a fluorescent intensity value represents the amount of albumin reabsorbed per square area of proximal tubule. slaulede 2021-01-15T15:22:29Z PMID:25680709 VT:0010913 proximal tubular albumin uptake clinical_measurement_ontology CMO:0003636 proximal tubule albumin uptake to tubule area ratio A calculated measurement in which the average area of glomerular capillary peripheral tuft not covered by podocytes is divided by the total area of glomerular capillary peripheral tuft. It is a measure of how much capillary area is directly exposed to the urinary space of Bowman's capsule. slaulede 2021-01-28T13:10:18Z PMID:16400008 VT:0005325 percentage of glomerular capillary peripheral tuft not covered by podocytes to total area of glomerular capillary peripheral tuft ratio of area of glomerular capillary peripheral tuft not covered by body of podocytes to total area of glomerular capillary peripheral tuft ratio of glomerular capillary peripheral tuft not covered by body of podocytes to total glomerular capillary peripheral tuft clinical_measurement_ontology CMO:0003643 ratio of area of glomerular capillary peripheral tuft not covered by podocytes to total area of glomerular capillary peripheral tuft The average measurements of planes through hyperplastic lesions of the tunica intima and tunica media, that is, a cross-section of the arterial wall from endothelium through the external elastic lamina. A hyperplastic lesion is a localized pathological increase in the number of cells of an organ or tissue resulting from an increased rate of cellular division due to injury or disease. slaulede 2021-02-04T17:20:24Z PMID:10364562 artery intimal hyperplastic lesion area including tunica media clinical_measurement_ontology CMO:0003645 artery neointimal hyperplastic lesion area including tunica media The circular vessel area of an artery is the area of the tunica intima with a patent lumen. Because arteries sometimes collapse during experimental processing, the circular vessel area (CA) can be calculated by measuring a length of the internal elastic lamina (IEL) of an artery and applying the following formula: CA=(IEL x IEL)/4&#960;. slaulede 2021-02-04T17:56:08Z PMID:10364562 clinical_measurement_ontology CMO:0003646 circular vessel area A measurement of blood vessel area which has been normalized or adjusted by a mathematical process or computation. slaulede 2021-02-04T18:41:32Z clinical_measurement_ontology CMO:0003647 calculated blood vessel area CVP (central venous pressure) is the pressure in the thoracic vena cava near the right atrium (therefore, CVP and right atrial pressure are essentially the same). Central venous pressure is an important concept in clinical cardiology because it is a major determinant of the filling pressure and therefore the preload of the right ventricle. slaulede 2021-02-08T17:38:55Z PMID:22258067 VT:2000002 CVP clinical_measurement_ontology CMO:0003657 central venous pressure The average number of capillaries associated with and/or surrounding an individual cardiac muscle fiber, a cylindrical multinucleate cell of cardiac muscle tissue containing contracting myofibrils. Capillaries are the minute vessels connecting arterioles and venules, the walls of which act as a semipermeable membrane for interchange of various substances between the blood and tissue fluid. slaulede 2021-02-08T18:29:08Z PMID:22258067 VT:0010945 number of capillaries per cardiac muscle fiber clinical_measurement_ontology CMO:0003658 number of capillaries per cardiomyocyte This is a measure of the relaxation caused by the addition of A23187 to a pre-constricted blood vessel. It is the ratio of the amount of dilation compared to a fully dilated blood vessel. slaulede 2021-02-09T17:36:41Z CHEBI:3305 MESH:D000001 VT:0000197 calcimycin-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel clinical_measurement_ontology CMO:0003660 A23187-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel A linear measurement of the outer part of the kidney made from the outer edge of the renal medulla to the capsule of the kidney. The cortex is composed mainly of glomeruli and convoluted tubules. slaulede 2021-03-15T15:02:50Z PMID:6602356 VT:0000521 kidney cortex thickness clinical_measurement_ontology CMO:0003670 renal cortex thickness A linear measurement made from one edge to the other edge across the widest portion of a single Bowman's capsule. Bowman's capsule is the expanded portion of the nephron encircling the glomerulus. slaulede 2021-03-15T15:24:45Z PMID:6602356 VT:0003670 Muller's capsule diameter malpighian capsule diameter clinical_measurement_ontology CMO:0003671 Bowman's capsule diameter Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the nephrons of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. slaulede 2021-03-15T16:33:21Z PMID:3199667 clinical_measurement_ontology CMO:0003672 calculated nephron measurement A calculated estimate of the size of the three dimensional space occupied by a single Bowman's capsule in the kidney. Bowman's capsule is the expanded portion of the nephron encircling the glomerulus. slaulede 2021-03-15T16:45:18Z PMID:3199667 VT:0003670 Muller's capsule volume malpighian capsule volume clinical_measurement_ontology CMO:0003673 Bowman's capsule volume The number of glomeruli per unit area of kidney. Based on stereological principles, the number of glomeruli per unit area of kidney equals the number of glomeruli per unit volume of kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation. slaulede 2021-03-15T17:44:35Z PMID:3199667 VT:0010544 glomerular density glomeruli count per unit area glomerulus count per unit area clinical_measurement_ontology CMO:0003674 kidney glomerular density Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to norepinephrine, a catecholamine which can act as a neurotransmitter, a stress hormone and a vasoconstrictor. slaulede 2021-03-19T10:29:52Z CHEBI:33569 PMID:23868088 noradrenaline response/sensitivity measurement clinical_measurement_ontology CMO:0003675 norepinephrine response/sensitivity measurement A calculated measurement in which the difference between the contractile force of a blood vessel in response to a specified dosage of norepinephrine and the baseline contractile force exerted by that vessel in the absence of any external stimuli, is divided by the baseline contractile force measurement and the result expressed as a percentage. Norepinephrine is a catecholamine which can act as a neurotransmitter, a stress hormone and a vasoconstrictor. slaulede 2021-03-19T10:52:38Z CHEBI:33569 PMID:23868088 noradrenaline-induced blood vessel contractile force expressed as percent of force at baseline clinical_measurement_ontology CMO:0003676 norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline A calculated value for logarithm of the concentration of norepinephrine at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of norepinephrine is halfway between the baseline value and the highest achievable value of such norepinephrine-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. slaulede 2021-03-19T11:04:41Z CHEBI:33569 PMID:23868088 logarithm of the concentration of noradrenaline at which the force of blood vessel contraction is half the maximum value noradrenaline -pEC50 noradrenaline Log EC50 clinical_measurement_ontology CMO:0003677 logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value The VLP is a high-frequency and very-low-intensity signal that is localized at the end of QRS duration, and on the beginning part of a ST segment. slaulede 2021-03-23T17:11:53Z PMID:24388923 VT:2000017 CV VLP clinical_measurement_ontology LP Late potentials determinate LP CMO:0003678 ventricular late potential A measurement of the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of the indigestible polysaccharide inulin. slaulede 2021-03-30T11:34:26Z RGD:25314254 VT:0002847 clinical_measurement_ontology RPF CMO:0003683 renal plasma flow (inulin) A measurement of the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of the non-metabolizable solute para-aminohippurate (PAH). slaulede 2021-03-30T11:51:49Z RGD:25314254 VT:0002847 renal plasma flow (para-aminohippurate) clinical_measurement_ontology RPF CMO:0003684 renal plasma flow (PAH) A calculated measurement in which the renal plasma flow rate (RPF) is divided by weight (i.e. the heaviness or the degree to which an object is drawn toward the earth by gravity) of one kidney and presented as a ratio, fraction, quotient or percentage. The RPF is the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of the indigestible polysaccharide inulin. slaulede 2021-03-30T11:58:32Z RGD:25314254 VT:0002847 ratio of RPF to kidney weight (inulin) clinical_measurement_ontology CMO:0003685 ratio of renal plasma flow to kidney weight (inulin) A calculated measurement in which the renal plasma flow rate (RPF) is divided by weight (i.e. the heaviness or the degree to which an object is drawn toward the earth by gravity) of one kidney and presented as a ratio, fraction, quotient or percentage. The RPF is the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of the non-metabolizable solute para-aminohippurate (PAH). slaulede 2021-03-30T12:04:41Z RGD:25314254 VT:0002847 ratio of RPF to kidney weight (PAH) clinical_measurement_ontology CMO:0003686 ratio of renal plasma flow to kidney weight (PAH) Volume of blood plasma delivered by a single glomerulus per unit time. slaulede 2021-04-15T19:07:19Z PMID:2846658 Qe single glomerular efferent plasma flow clinical_measurement_ontology CMO:0003697 efferent arteriolar plasma flow rate This is a calculated value based on the number of capillary profiles counted in microscopic images of glomerular tufts. The total calculated length of capillaries is expressed per glomerulus. slaulede 2021-05-11T13:54:32Z PMID:7894005 VT:0010911 Lcap average total length of capillaries per glomerulus clinical_measurement_ontology CMO:0003708 mean length density of glomerular capillaries This is a calculated value estimated from the glomerular filtering surface area of the peripheral capillary wall per unit glomerular volume. It is based on the proportion of the peripheral capillary basement membrane in contact with epithelial podocytes, as determined by microscopic measurements. slaulede 2021-05-11T14:27:01Z Spcw PMID:7894005 VT:0005325 ratio of glomerular filtering surface area to glomerular volume surface density of the filtering surface area clinical_measurement_ontology CMO:0003709 glomerular filtering surface area to glomerular volume ratio This is a calculated value estimated from the average total glomerular filtering surface area of the peripheral capillary wall per glomerulus. It is based on the proportion of the peripheral capillary basement membrane in contact with epithelial podocytes, as determined by microscopic measurements. slaulede 2021-05-11T14:37:50Z Spcw PMID:7894005 VT:0005325 filtering surface area per glomerulus clinical_measurement_ontology CMO:0003710 total filtering surface area per glomerulus Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the glomerular podocytes of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. slaulede 2021-05-11T15:43:06Z PMID:7894005 calculated kidney glomerular visceral epithelial cell measurement calculated podocyte measurement clinical_measurement_ontology CMO:0003711 calculated kidney glomerular podocyte measurement This is a calculated value estimated from the glomerular filtering surface area of the peripheral capillary wall and the epithelial filtration slit frequency. The measurements for the calculations are from computerized analysis of electron micrographs. slaulede 2021-05-11T16:47:47Z PMID:7894005 VT:0005326 total glomerular visceral epithelial cell slit length total podocyte slit length clinical_measurement_ontology CMO:0003712 total pericapillary slit length This is an average value for the gap distance between interdigitating foot processes of podocytes in kidney glomeruli. The value is derived from the measurements of podocytes during computerized analysis of electron micrographs. slaulede 2021-05-11T17:04:00Z PMID:7894005 VT:0005326 glomerular podocyte slit width glomerular visceral epithelial cell slit width clinical_measurement_ontology CMO:0003713 podocyte slit width This is a calculated value estimated from the measurement of foot processes and an equation adjusting for ambiguity of electron microscopic images of podocyte foot process boundaries. slaulede 2021-05-11T17:17:55Z PMID:10703671 PMID:7894005 VT:0005326 Epithelial foot process width WFP glomerular podocyte foot process width glomerular visceral epithelial cell foot process width podocyte pedicel width clinical_measurement_ontology CMO:0003714 podocyte foot process width This is an average value of the distance between the basal side of the podocyte contacting the basement membrane and the apical side of the podocyte projecting into the urinary space. The value is derived from the measurements of podocytes during computerized analysis of electron micrographs. slaulede 2021-05-11T17:25:35Z PMID:7894005 VT:0005326 glomerular podocyte foot process height glomerular visceral epithelial cell foot process height podocyte pedicel height clinical_measurement_ontology CMO:0003715 podocyte foot process height This is a calculated value made by dividing the total mesangial volume measurement by the total number of glomeruli measured, both values having been determined from measurements of microscopic images. Alternately, the fractional mesangial volume (FMV) may be multiplied by the mean glomerular volume (GV) to get the total mesangial volume (TMV). slaulede 2021-05-13T14:02:06Z Vmes PMID:7894005 VT:0005325 TMV kidney mesangial volume per glomerulus clinical_measurement_ontology CMO:0003716 mesangium volume per glomerulus Pulse wave velocity (PWV) is a measurement of arterial stiffness that is an independent predictor of cardiovascular risk. It can be measured simply and noninvasively by measuring the carotid and femoral pulse pressures and the time delay between the two or by other methods relying on pulse-wave analysis. slaulede 2021-05-20T15:30:59Z EFO:0004517 EFO:0004724 PMID:32088716 Carotid–femoral PWV PWV arterial stiffness measurement carotid-femoral pulse wave velocity clinical_measurement_ontology CMO:0003717 pulse wave velocity A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of pulse pressure, the difference between systolic and diastolic blood pressures. slaulede 2021-05-20T15:53:45Z PMID:32088716 clinical_measurement_ontology CMO:0003718 calculated pulse pressure measurement A measurement of the depth of the wall of a mesenteric artery, either of two arteries arising from the aorta and passing between the two layers of the mesentery to the intestine. slaulede 2021-05-20T16:53:26Z PMID:32088716 clinical_measurement_ontology CMO:0003719 mesenteric artery wall thickness A measurement of the depth of the tunica media of a mesenteric artery. The tunica media is the middle layer of the mesenteric arterial wall, containing smooth muscle and elastic tissue. slaulede 2021-05-20T17:03:50Z PMID:32088716 mesenteric artery tunica media thickness clinical_measurement_ontology CMO:0003720 mesenteric artery media thickness A measurement of the depth of the tunica adventitia of a mesenteric artery. The tunica adventitia is the outermost layer of the mesenteric arterial wall, composed mainly of fibrous tissue. slaulede 2021-05-20T17:23:07Z PMID:32088716 mesenteric artery tunica adventitia thickness clinical_measurement_ontology CMO:0003721 mesenteric artery adventitial thickness The length of a line which crosses a transverse view of an arteriole, passing through its center and ending on either side at the outer surface of the arteriole wall. An arteriole is the smallest division of the artery located between the muscular arteries and capillaries. slaulede 2021-06-11T16:50:24Z PMID:27270176 clinical_measurement_ontology CMO:0003724 arteriole diameter The length of a line which crosses a transverse view of a renal afferent arteriole, passing through its center and ending on either side at the outer surface of the arteriole wall. A renal afferent arteriole is one of the blood vessels that branch from the kidney interlobular artery and conveys blood to the glomerular capillaries. slaulede 2021-06-11T16:57:17Z PMID:27270176 clinical_measurement_ontology CMO:0003725 renal afferent arteriole diameter A calculated value for the negative logarithm of the molar concentration of acetylcholine (ACh), which acts as a neurotransmitter, at which the dilation of a blood vessel in response to the application of ACh is half maximal. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. slaulede 2021-06-18T15:57:10Z PMID:32088716 ACh pD2 acetylcholine -Log EC50 acetylcholine -Log half maximal effective concentration (-Log EC50) clinical_measurement_ontology CMO:0003728 negative logarithm of the molar concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value Any measurement of a lesion in the heart characterized by an abnormal proliferation of fibrous connective tissue. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. slaulede 2021-06-29T12:19:38Z PMID:20864942 clinical_measurement_ontology CMO:0003740 heart fibrotic lesion measurement Any measurement of a lesion in the left ventricle of the heart characterized by an abnormal proliferation of fibrous connective tissue. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. slaulede 2021-06-29T12:29:24Z PMID:20864942 clinical_measurement_ontology CMO:0003741 heart left ventricle fibrotic lesion measurement This is any measurement of the physical dimensions, proportions, magnitude, or extent of a lesion in the left ventricle of the heart characterized by an abnormal proliferation of fibrous connective tissue. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. slaulede 2021-06-29T12:34:47Z PMID:20864942 clinical_measurement_ontology CMO:0003742 heart left ventricle fibrotic lesion size measurement This is a measurement of the extent of a two-dimensional surface of or plane through a single heart left ventricle fibrotic lesion, or a measurement of the total area occupied by fibrotic lesions in a cross-section of the heart left ventricle. slaulede 2021-06-29T12:49:29Z PMID:20864942 clinical_measurement_ontology CMO:0003743 heart left ventricle fibrotic lesion area measurement This is a measurement of the extent of a two-dimensional surface of or plane through a single heart left ventricle fibrotic lesion, or a measurement of the total area occupied by fibrotic lesions in a cross-section of the heart left ventricle, when that value has been normalized, adjusted or derived by a mathematical process or computation. slaulede 2021-06-29T12:53:13Z PMID:20864942 clinical_measurement_ontology CMO:0003744 calculated heart left ventricle fibrotic lesion area measurement This is a calculated value in which the extent of the two-dimensional surface occupied by interstitial fibrotic lesions is divided by the total extent of the two-dimensional surface of the heart left ventricle and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the size of the heart left ventricle. slaulede 2021-06-29T13:09:59Z PMID:20864942 clinical_measurement_ontology CMO:0003745 heart left ventricle interstitial fibrotic lesion area to total heart left ventricule area ratio This is calculated value in which the extent of the two-dimensional surface occupied by perivascular fibrotic lesions is divided by the total extent of the two-dimensional surface of the heart left ventricle and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the size of the heart left ventricle. slaulede 2021-06-29T13:13:15Z PMID:20864942 clinical_measurement_ontology CMO:0003746 heart left ventricle perivascular fibrotic lesion area to total heart left ventricule area ratio This measurement is a calculated value in which the extent of the two-dimensional area occupied by fibrotic lesions is divided by the total extent of the two-dimensional area of the kidney and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the size of the kidney. The two-dimensional measurements are made on microscopic images. slaulede 2021-06-29T13:30:36Z CMO:0001258 PMID:20864942 kidney fibrotic lesion cross-sectional area to total kidney cross-sectional area ratio clinical_measurement_ontology CMO:0003747 kidney interstitial fibrotic lesion area to total kidney area ratio A calculated measurement in which the average volume of kidney glomeruli is divided by the average number of podocytes in a glomerulus. It represents the reciprocal value of 'number of podocytes to glomerular volume ratio (CMO:0002955). slaulede 2021-06-29T15:56:32Z PMID:18199599 clinical_measurement_ontology CMO:0003748 glomerular volume per podocyte This measurement defines the capacity of a porous material to transmit fluids. Darcy's law is an equation that describes the flow of a fluid through a porous medium. The calculation in biological systems relies on a pressure gradient, the thickness of the material through which the fluid is proceeding, and the dynamic viscosity of the filtration solution. slaulede 2021-07-01T13:46:56Z PMID:10703671 Darcy permeability of GBM layers clinical_measurement_ontology CMO:0003749 Darcy permeability Calculated value for average volume of glomerular capillary tuft not affected by sclerotic changes in sampled subjects. slaulede 2021-07-02T10:56:41Z PMID:16395266 volume of normal glomerular capillary tuft clinical_measurement_ontology CMO:0003750 volume of glomerular capillary tuft not affected by sclerosis Calculated value for average volume of glomerular capillary tuft occupied by sclerotic changes in sampled subjects. slaulede 2021-07-02T11:13:51Z PMID:16395266 clinical_measurement_ontology CMO:0003751 volume of glomerular capillary tuft occupied by sclerosis A calculated measurement in which the average volume of interstitial space in the renal cortex is divided by the average total volume of the renal cortex and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to kidney cortical volume and, by extension, to the size of the kidney. slaulede 2021-07-02T11:54:47Z PMID:16395266 volume of interstitial kidney cortex to total volume of kidney cortex ratio clinical_measurement_ontology CMO:0003752 volume of kidney cortical interstitium to total volume of kidney cortex ratio A calculated measurement in which the area of a heart left ventricle infarction is divided by the total area of the heart left ventricle, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to heart left ventricle size and, by extension, to the size of the heart. slaulede 2021-07-02T18:31:48Z PMID:14962492 PMID:22258067 clinical_measurement_ontology CMO:0003756 heart left ventricle infarction area to total heart left ventricle area ratio The number of glomeruli calculated to be in one kidney from a measured sample of that kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation. slaulede 2021-07-22T15:56:54Z PMID:17167120 glomerulus count per kidney clinical_measurement_ontology CMO:0003797 number of glomeruli per kidney Any count that has been normalized, adjusted or derived by a mathematical process or computation, of the glomeruli of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. slaulede 2021-07-22T16:02:09Z PMID:23241663 calculated glomerulus count calculated renal glomerulus count clinical_measurement_ontology Not4Curation CMO:0003798 calculated kidney glomerulus count A count that has been normalized, adjusted or derived by a mathematical process or computation, of the glomeruli in a given volume of kidney tissue. slaulede 2021-07-22T16:41:13Z PMID:23241663 number of kidney glomeruli per volume of tissue clinical_measurement_ontology CMO:0003799 number of glomeruli per volume of kidney Measurement of the physical form or structure of the renal cortex, the outer part of the kidney, composed mainly of glomeruli and convoluted tubules. slaulede 2021-07-27T17:26:08Z PMID:3199667 kidney cortex morphological measurement clinical_measurement_ontology CMO:0003811 renal cortex morphological measurement A measurement of the outer extent of a plane perpendicular through the hilum, the opening on the medial margin of the kidney leading into the renal sinus. Its value may be calculated from or measured via a microscopic image. slaulede 2021-07-27T17:46:05Z PMID:3199667 kidney cortex cross-sectional area clinical_measurement_ontology CMO:0003812 renal cortex cross-sectional area Measurement of average carotid artery blood flow velocity, the speed with which blood moves along the circulation in any particular segment of carotid artery. Blood flow velocity is related directly to blood flow and inversely to cross-sectional area. Blood flow velocity can be measured indirectly by Doppler ultrasound slaulede 2021-07-29T15:24:26Z carotid flow velocity PMID:29498562 mean carotid artery blood flow velocity clinical_measurement_ontology CMO:0003813 carotid artery blood flow velocity Measurement of peak carotid artery blood flow velocity, the top speed (systolic) with which blood moves along the circulation in any particular segment of carotid artery. Blood flow velocity is related directly to blood flow and inversely to cross-sectional area. Blood flow velocity can be measured indirectly by Doppler ultrasound slaulede 2021-07-29T15:31:59Z peak (systolic) flow velocity PMID:29498562 peak carotid artery flow velocity clinical_measurement_ontology CMO:0003814 peak carotid artery blood flow velocity Cerebral blood flow (CBF) rate is the volume of blood delivered to or exiting the brain, through a network of cerebral arteries and veins, per unit time slaulede 2021-07-29T16:36:46Z EFO:0007980 PMID:27403447 PMID:29498562 CBF rate cerebral blood flow measurement clinical_measurement_ontology CMO:0003815 cerebral blood flow rate Any measurement which has been normalized or adjusted by a mathematical process or computation of the minute vessels connecting arterioles and venules, the walls of which act as a semipermeable membrane for interchange of various substances between the blood and tissue fluid. slaulede 2021-08-27T17:18:03Z PMID:22258067 clinical_measurement_ontology CMO:0003837 calculated capillary measurement A calculated number of capillaries associated with a sampled cross-sectional area of left ventricular myocardium, the muscular layer of the ventricle. Capillaries are the minute vessels connecting arterioles and venules, the walls of which act as a semipermeable membrane for interchange of various substances between the blood and tissue fluid. slaulede 2021-08-27T17:28:15Z capillary density PMID:22258067 VT:0010945 clinical_measurement_ontology CMO:0003838 number of capillaries per cross-sectional area of left ventricular myocardium A measurement of the extent of a plane through, that is, perpendicular to the axis of, a cardiac myocyte, striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. slaulede 2021-09-09T18:12:17Z PMID:22258067 cardiac fiber cross-sectional area cardiac muscle fiber cross-sectional area cardiomyocyte cross-sectional area heart muscle cell cross-sectional area striated cardiac muscle cell cross-sectional area clinical_measurement_ontology CMO:0003840 cardiac myocyte cross-sectional area This is a measurement of the number of ureteric bud tips calculated to be in one kidney from a measured sample of that kidney. Ureteric bud tips are at the terminal ends of the ureteric tree. The ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis. slaulede 2021-10-11T16:34:29Z PMID:22871889 ureteric bud tip count per kidney clinical_measurement_ontology CMO:0003848 number of ureteric bud tips per kidney A calculated measurement in which the average number of glomeruli calculated to be in one kidney is divided by the average number of ureteric bud tips calculated to be in one kidney and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to one kidney. slaulede 2021-10-11T17:17:48Z PMID:22871889 count of glomeruli per kidney to count of ureteric bud tips per kidney ratio clinical_measurement_ontology CMO:0003849 number of glomeruli per kidney to number of ureteric bud tips per kidney ratio A calculated value in which the total amount of protein in a kidney is divided by the total weight of the body and presented as a ratio thus normalizing it to body weight. slaulede 2021-10-21T18:44:50Z PMID:2838080 total weight of kidney protein to whole kidney weight ratio clinical_measurement_ontology CMO:0003850 total kidney protein to kidney weight ratio The diameter across the inside of the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter. slaulede 2021-10-26T15:27:30Z LVIDs heart left ventricular end-systolic internal diameter left ventricular internal dimension at systole clinical_measurement_ontology CMO:0003851 heart left ventricle end-systolic internal diameter A calculated measurement in which the average volume of glomerular capillary tuft occupied by sclerotic changes is divided by the total average total volume of glomerular capillary tuft with the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to total of glomerular capillary tuft volume. slaulede 2021-11-05T17:36:50Z PMID:16395266 percentage of tuft volume affected by sclerosis clinical_measurement_ontology CMO:0003864 volume of glomerular capillary tuft occupied by sclerosis to volume of total glomerular capillary tuft ratio A calculated measurement in which the average number of healthy glomeruli per subject is divided by the average total number of glomeruli per subject with the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to total number of glomeruli. slaulede 2021-11-05T18:01:34Z PMID:16395266 clinical_measurement_ontology CMO:0003865 healthy glomeruli to total glomeruli ratio A calculated value in which sum of the weight of the left ventricle and the weight of the interventricular septum is divided by the total weight of the body with the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and by extension to the size of the organism. slaulede 2021-11-19T17:25:30Z PMID:15721482 LV+SEP/BW clinical_measurement_ontology CMO:0003869 heart left ventricle plus septum weight to body weight ratio This is the level of urea in the blood; converted from urea nitrogen to urea concentration by multiplying urea nitrogen concentration by 60/28 or 2.14. Urea is the chief nitrogenous end product of protein metabolism in whole blood. Urea is formed in the liver from amino acids and from ammonia compounds and can be found in urine, blood, and lymph. slaulede 2022-02-25T09:23:49Z blood urea concentration clinical_measurement_ontology CMO:0003876 blood urea level This is a measurement which has been normalized, adjusted or derived by a mathematical process or computation, of mean arterial blood pressure, the average blood pressure within an artery over a specified period of time. slaulede 2022-07-08T15:09:23Z PMID:15458950 clinical_measurement_ontology CMO:0003895 calculated mean arterial blood pressure measurement This calculated measurement is the range of change in heart rate (the number of contractions of the cardiac ventricles per unit of time) relative to the change in mean arterial blood pressure (the average force the blood exerts on an artery wall) over time and/or in response to a change in conditions. slaulede 2022-07-11T16:35:24Z range of change in HR during changes in MAP range of change in heart rate during changes in mean arterial blood pressure range of variation in HR during variation in MAP clinical_measurement_ontology CMO:0003896 range of heart rate variation during variation of mean arterial blood pressure This is a calculated measurement in which the difference in the heart rate recorded between two or more dosages of a drug or chemical which reduces or increases the interior diameter of blood vessels is divided by the difference of the applied dosages and presented as a ratio, fraction, quotient or percentage. The value is calculated as the slope of the curve of the heart rate versus the chemical dose graph. slaulede 2022-09-20T17:08:47Z beta coefficent of the heart rate/ vasoactive chemical dose curve index of baroreceptor sensitivity slope of the heart rate/ vasoactive chemical dose curve clinical_measurement_ontology CMO:0003904 change in heart rate to change in vasoactive chemical dose ratio This is calculated value in which the extent of the two-dimensional surface occupied by atherosclerotic lesion(s) is divided by the total extent of the two-dimensional surface of the artery and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the size of the artery. slaulede 2022-09-29T09:47:33Z lesioned artery area to total artery area ratio PMID:28469073 average atherosclerotic area atherosclerotic area as percentage of total clinical_measurement_ontology CMO:0003905 area of atherosclerotic lesion to total artery area ratio This is a calculated measurement of the pressure gradient that drives coronary blood pressure. CPP can be measured by calculating the difference between the aortic pressure and the left ventricular end diastolic pressure: Coronary Perfusion Pressure (CPP) = Aortic Diastolic Pressure – Left Ventricular end-diastolic Pressure (LVEDP). slaulede 2022-10-10T13:14:15Z CPP clinical_measurement_ontology CMO:0003906 coronary perfusion pressure The is a measurement of the amount of blood perfusing the heart muscle through the coronary arteries per unit time. slaulede 2022-10-10T13:42:52Z clinical_measurement_ontology CMO:0003907 coronary blood flow rate The is a measurement of the amount of blood perfusing the heart muscle through the coronary arteries per unit time, divided by the total weight of the heart, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing coronary blood flow rate to heart weight. slaulede 2022-10-10T13:49:52Z coronary blood flow per gram of heart tissue clinical_measurement_ontology CMO:0003908 coronary blood flow rate to heart weight ratio This is quantification of a morphological or physiological parameter of one or more nucleic acids in a specified sample of kidney tissue, that is, tissue from one or both of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. Nucleic acids are high-molecular-weight polymeric compounds composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose or deoxyribose sugar, and a phosphate group, and are involved in the determination and transmission of genetic characteristics. slaulede 2023-03-13T17:03:59Z renal nucleic acid measurement clinical_measurement_ontology CMO:0003911 kidney nucleic acid measurement This is any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) that reside in the kidney. Ribonucleic acids are high-molecular-weight polymeric compounds composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose sugar, and a phosphate group. They are involved in the determination and transmission of genetic characteristics. slaulede 2023-03-13T17:13:14Z CMO:0002797 kidney RNA composition measurement kidney ribonucleic acid composition measurement VT:0010793 renal RNA level renal ribonucleic acid level clinical_measurement_ontology CMO:0003912 kidney ribonucleic acid level This is the measurement of the amount of messenger ribonucleic acid (mRNA) which codes for the amino acid sequences of proteins in a specified sample of kidney. slaulede 2023-03-13T17:18:54Z kidney messenger RNA level kidney messenger ribonucleic acid level renal mRNA level clinical_measurement_ontology CMO:0003913 kidney mRNA level This measurement is a calculated/estimated value of the relative mass of total fluid in an organism. The two main fluid compartments are divided by the cell membrane into the extracellular fluid (ECF) and the intracellular fluid (ICF). slaulede 2023-08-11T17:07:21Z PMID:37191987 TBW weight total body fluid mass clinical_measurement_ontology total body fluid weight CMO:0003942 total body water mass This is a measurement that determines whole body lean tissue mass of an organism by subtracting whole body fat mass from total body mass. slaulede 2023-08-21T13:38:35Z PMID:37191987 whole body fat-free mass clinical_measurement_ontology total body fat-free weight CMO:0003944 total body fat-free mass This is a calculated measurement of the average cross-sectional area of glomeruli sampled in microscopic images. slaulede 2023-09-29T14:35:28Z average kidney glomerulus cross-sectional area kidney glomerular area clinical_measurement_ontology CMO:0003960 kidney glomerulus area This is a calculated measurement in which the average number of damaged kidney cortex tubules per subject is divided by the average total number of kidney cortex tubules per subject with the result presented as a ratio, thus normalizing the number of damaged tubules to total number of tubules. slaulede 2023-09-29T15:03:57Z percentage of damaged kidney cortex tubules percentage of damaged renal cortex tubules renal cortex damaged tubule count to renal cortex total tubule count ratio clinical_measurement_ontology CMO:0003961 kidney cortex damaged tubule count to kidney cortex total tubule count ratio This is a calculated measurement in which the average number of damaged kidney medulla tubules per subject is divided by the average total number of kidney medulla tubules per subject with the result presented as a ratio, thus normalizing the number of damaged tubules to the total number of tubules. slaulede 2023-09-29T15:17:14Z percentage of damaged kidney medulla tubules percentage of damaged renal medulla tubules renal medulla damaged tubule count to renal medulla total tubule count ratio clinical_measurement_ontology CMO:0003962 kidney medulla damaged tubule count to kidney medulla total tubule count ratio This is any quantification of the physical form or structure of the largest veins (superior vena cava and inferior vena cava in mammals) which deliver de-oxygenated blood from throughout the body back to the right cardiac atrium. slaulederkind 2024-03-05T14:21:38Z PMID:36733943 caval vein morphological measurement venae cavae morphological measurement clinical_measurement_ontology CMO:0003978 vena cava morphological measurement This is any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the largest veins (superior vena cava and inferior vena cava in mammals) which deliver de-oxygenated blood from throughout the body back to the right cardiac atrium. slaulederkind 2024-03-05T14:30:56Z PMID:36733943 caval vein molecular composition measurement venae cavae molecular composition measurement clinical_measurement_ontology CMO:0003979 vena cava molecular composition measurement This is any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) found in the largest veins (superior vena cava and inferior vena cava in mammals) which deliver de-oxygenated blood from throughout the body back to the right cardiac atrium. slaulederkind 2024-03-05T15:08:39Z PMID:36733943 caval vein RNA level caval vein ribonucleic acid level vena cava RNA level venae cavae RNA level venae cavae ribonucleic acid level clinical_measurement_ontology CMO:0003980 vena cava ribonucleic acid level This is a measurement of the amount of ribonucleic acid (RNA), the molecule composed of the sugar ribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or uracil, extracted from or contained in the heart right atrium, the upper chamber of the right side of the heart, which receives deoxygenated blood from the venae cavae and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. slaulederkind 2024-04-02T13:51:49Z VT:0011109 heart right atrium RNA level heart right atrium ribonucleic acid amount right cardiac atrium RNA level right cardiac atrium ribonucleic acid amount clinical_measurement_ontology CMO:0003984 heart right atrium ribonucleic acid level This is an ex vivo measurement of the length of a line which crosses a transverse view of a calcium-free physiological salt solution (PSS)-perfused (80 mmHg equilibrium pressure) middle cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain. slaulederkind 2024-06-04T11:15:45Z maximim diameter of middle cerebral artery perfused in bicarbonate-buffered, calcium-free saline Dmax maximim lumen diameter of middle cerebral artery perfused in bicarbonate-buffered, calcium-free PSS maximum inner diameter of MCA perfused in calcium-free PSS clinical_measurement_ontology CMO:0003997 maximim inner diameter of middle cerebral artery perfused in bicarbonate-buffered, calcium-free saline This is an ex vivo measurement of the length of a line which crosses a transverse view of a saline-perfused (80 mmHg equilibrium pressure) middle cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain. slaulederkind 2024-06-04T12:15:20Z Drest lumen diameter of middle cerebral artery perfused in bicarbonate-buffered, normal saline resting diameter of middle cerebral artery perfused in bicarbonate-buffered, normal physiological salt solution resting inner diameter of MCA perfused in normal PSS clinical_measurement_ontology CMO:0003998 resting inner diameter of middle cerebral artery perfused in bicarbonate-buffered, normal saline This is any quantification of the physical form or structure of a vein, any of the tubular branching vessels that carry blood from the capillaries toward the heart. slaulederkind 2024-11-18T16:36:50Z clinical_measurement_ontology CMO:0004031 vein morphological measurement This is any quantification of the physical form or structure of a pulmonary vein, a blood vessel that transport bloods from the lungs to the heart slaulederkind 2024-11-18T17:30:59Z clinical_measurement_ontology CMO:0004032 pulmonary vein morphological measurement This is any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the right pulmonary vein, the vein that drains the right lung and returns blood to the heart.. slaulederkind 2024-12-02T13:36:32Z clinical_measurement_ontology CMO:0004033 right pulmonary vein molecular composition measurement Any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) of which the tissue of the right pulmonary vein is formed or composed. slaulederkind 2024-12-02T13:56:14Z VT:0011142 right pulmonary vein RNA level clinical_measurement_ontology CMO:0004034 right pulmonary vein ribonucleic acid level This is any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) found in a nephron tubule that connects the glomerular capsule to the loop of Henle. It has a brush border epithelial morphology. caripark 2025-11-24T11:37:21Z GEO:GSE194236 kidney proximal tubule RNA level kidney proximal tubule ribonucleic acid level proximal tubule RNA level renal proximal tubule RNA level renal proximal tubule ribonucleic acid level clinical_measurement_ontology CMO:0004128 proximal tubule ribonucleic acid level This is any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) found in the pericardial sac, a double-walled sac (serous plus fibrous pericardium) containing the heart and the roots of the great vessels. caripark 2026-03-17T07:34:40Z GEO:GSE282713 PMID:41022776 pericardium RNA level clinical_measurement_ontology CMO:0004138 pericardium ribonucleic acid level This is any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) found in the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart left ventricle wall. caripark 2026-03-17T07:48:19Z GEO:GSE282713 PMID:41022776 VT:0011039 heart left ventricle myocardium RNA level clinical_measurement_ontology CMO:0004139 heart left ventricle myocardium ribonucleic acid level Any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) in the renal glomerulus, a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. caripark 2026-04-20T08:21:05Z GEO:GSE179945 GEO:GSE286014 PMID:35310946 PMID:40397520 VT:0011298 kidney glomerulus RNA level kidney glomerulus ribonucleic acid level renal glomerulus RNA level clinical_measurement_ontology CMO:0004147 renal glomerulus ribonucleic acid level the role of a material entity to prevent, diagnose, treat, or study disease and/or its effects William Hogan William Hogan clinical drug role a material entity (1) containing at least one scattered molecular aggregate as part that is the bearer of an active ingredient role and (2) that is itself the bearer of a clinical drug role William Hogan William Hogan drug product active ingredient role a role of a scattered molecular aggregate that is part of a drug product that is realized by (1) administration of the drug to an organism followed by (2) some change in the structure or functioning of some part of the organism William R. Hogan active ingredient role of a scattered molecular aggregate a role borne by a scattered molecular aggregate and realized by its grains participating in one or more processes William R. Hogan role of scattered molecular aggregate administration of a drug product to an organism a treatment that has as participants an extended organism and a drug product and that results in part of the drug product being located in the extended organism William R. Hogan drug administration https://en.wikipedia.org/wiki/Geographic_feature macroscopic spatial feature envoPolar May appear on a map. geographic feature An anthropogenic geographic feature is a geographic feature resulting from the influence of human beings on nature. An anthropogenic geographic feature is a geographic feature resulting from the influence of human beings on nature. FTT:78 TGN:50001 man-made feature manmade feature anthropogenic geographic feature FTT:1242 FTT:1252 FTT:15 FTT:16 FTT:18 FTT:19 FTT:21 FTT:22 FTT:23 FTT:24 FTT:25 FTT:26 FTT:27 FTT:28 FTT:29 FTT:37 SWEETRealm:AdministrativeRegion TGN:80001 TGN:81099 TGN:81123 https://en.wikipedia.org/wiki/Administrative_region administrative area administrative division administrative entity boundary region civil area district free trade zone governed place leased area (government) leased zone (government) neutral zone (political) prefecture protectorate sheikdom sultanate trade zone administrative region A political association with effective dominion over a geographic area. FTT:424 FTT:566 FTT:567 FTT:571 SWEETRealm:Country SWEETRealm:State TGN:80006 TGN:81010 TGN:81011 TGN:81102 https://en.wikipedia.org/wiki/Nation nation independent nation independent political entity independent sovereign nation ENVO country political entity state ENVO:00000009 national geopolitical entity 1 Place or area with clustered or scattered buildings and a permanent human population. place FTT:1097 FTT:33 Geonames:P.PPL Geonames:P.PPLS TGN:22201 TGN:83002 https://en.wikipedia.org/wiki/Populated_place inhabited place populated place populated places settlement ENVO inhabited region populated locality ENVO:00000062 populated place A feature that has been constructed by deliberate human effort. "constructed" should probably be made something like a quality and this class obsoleted or filled only by inference constructed feature construction A permanent walled and roofed construction. FTT:42 Geonames:S.BLDG LTER:76 TGN:51011 https://en.wikipedia.org/wiki/Building BUILDING building building A geographical region whose affairs and population are administered by an authority. FTT:1093 Geonames:A.PCL TGN:80002 political entity political entity Incorporated populated place. urban area EcoLexicon:city FTT:430 FTT:483 FTT:484 FTT:485 SWEETRealm:City TGN:83020 TGN:83040 TGN:83043 https://en.wikipedia.org/wiki/City ENVO ENVO:00000856 city An environmental feature that is, or can be, contained and is predominantly composed of one or a few types of stuff. An object which is large enough to be visible to humans, but small enough that humans can handle the object (i.e. transport it, examine it, etc) in its entirety with little to no technological assistance. mesoscopic physical object This is a legacy class from ENVO's early versions. It will be depopulated and filled in by inference using a PATO quality. Not to be confused with "mesoscopic" as defined in physics, which deals with objects typically between 10e-6 and 10-8 meters in diameter. mesoscopic physical object physical object of mesoscopic geological size A material entity which determines an environmental system. ENVO ENVO:00002297 A material entity determines an environmental system when its removal would cause the collapse of that system. For example, a seamount determines a seamount environment, acting as its 'hub'. This class is currently being aligned to the Basic Formal Ontology. Following this alignment, its definition and the definitions of its subclasses will be revised. environmental feature A material entity that has been processed by humans or their technology in any way, including intermediate products as well as final products. manufactured good manufactured product ENVO ENVO:00003075 anthropogenic abiotic mesoscopic feature A portion of environmental material is a fiat object part which forms the medium or part of the medium of an environmental system. A portion of environmental material is a fiat object which forms the medium or part of the medium of an environmental system. portion of environmental material Everything under this parent must be a mass noun. All subclasses are to be understood as being composed primarily of the named entity, rather than restricted to that entity. For example, "ENVO:water" is to be understood as "environmental material composed primarly of some CHEBI:water". This class is currently being aligned to the Basic Formal Ontology. Following this alignment, its definition and the definitions of its subclasses will be revised. environmental material ENVO ENVO:01000010 abiotic mesoscopic physical object A system which has the disposition to environ one or more material entities. 2013-09-23T16:04:08Z EcoLexicon:environment environment In ENVO's alignment with the Basic Formal Ontology, this class is being considered as a subclass of a proposed BFO class "system". The relation "environed_by" is also under development. Roughly, a system which includes a material entity (at least partially) within its site and causally influences that entity may be considered to environ it. Following the completion of this alignment, this class' definition and the definitions of its subclasses will be revised. environmental system An anthropogenic environment is an environmental system which is the product of human activity. Unsatisfactory definition here. Must consider the threshold that makes an environmental system anthropogenic. anthropogenic environment A site which has its extent determined by the presence or influence of one or more components of an environmental system or the processes occurring therein. environmental area envoPolar Formerly, this class was an experimental class and a subclass of "environmental feature". It is now aligned to BFO. The class was not obsoleted as the core semantics maintained their stability through its transition. environmental zone A building part is a construction which is part of a building. Not recommended for annotation. This class is likely to be made into an inferred class as its subclasses are distributed among more meaningful superclasses (i.e. ceiling is_a surface layer). See for example, "building floor". The boundaries between building parts may be bona fide or fiat. building part Outer space is a hard vacuum containing a low density of particles, predominantly a plasma of hydrogen and helium as well as electromagnetic radiation, magnetic fields, neutrinos, dust and cosmic rays that exists between celestial bodies. space envoAstro outer space A settlement with a high density of buildings and inhabitants. See also: http://www.ecotope.org/anthromes/v1/guide/urban/12_dense_settlements/default.aspx The thresholds for what makes a settlment "dense" can be determined as needed. If there is a specific threshold that should be added to ENVO, please make a new class request. dense settlement A self-contained constructed feature used by one or more households as a home, such as a house, apartment, mobile home, houseboat or other 'substantial' structure. A dwelling typically includes nearby outbuildings, sheds etc. within the curtilage of the property, excluding any 'open fields beyond'. It has significance in relation to search and seizure, conveyancing of real property, burglary, trespass, and land use planning. See https://github.com/EnvironmentOntology/envo/issues/264 for discussion. This definition needs a lot of clean up and links to household and related classes must be made to form logical definitions for inference to work. Subclasses will be added by inference. human dwelling A village is a clustered human settlement or community, larger than a hamlet but smaller than a town, with a population ranging from a few hundred to a few thousand. Though often located in rural areas, the term urban village is also applied to certain urban neighbourhoods. Villages are normally permanent, with fixed dwellings; however, transient villages can occur. Further, the dwellings of a village are fairly close to one another, not scattered broadly over the landscape, as a dispersed settlement. This class may be split. "urban village" doesn't sit well and prevents relations to village biomes. village An object which is naturally occuring, bound together by gravitational or electromagnetic forces, and surrounded by space. celestial body envoAstro Astronomical bodies are usually cohesive, thus the use of the term 'object' sensu BFO 'object'. astronomical body 1 An object which is composed of one or more gravitationally bound structures that are associated with a position in space. celestial object envoAstro If there is only one astronomical body involved, this class is equivalent to ENVO:01000799. This may be problematic with reasoning, but it seems to be true to the rather fuzzy definitions found thus far. astronomical object A material part of an astronomical body. envoAstro envoPolar astronomical body part A biosphere is a part of an astronomical body which includes, as parts, all the living entities within the gravitational sphere of influence of that body, as well as the non-living and dead entities with which they interact. A biosphere is an environmental system which includes, as parts, all the living entities within the gravitational sphere of influence of an astronomical body, and the non-living and dead entities which they interact with. Whether this class should be grouped with classes such as "hydrosphere" and "cryosphere" requires some discussion. envoAstro envoPolar The gravitational sphere of influence referenced in this class' definition is the Hill sphere: a region in which an object dominates the attraction of satellites despite gravitational perturbations. biosphere An environmental system in which minimal to no anthropisation has occurred and non-human agents are the primary determinants of the system's dynamics and composition. non-anthropised environment non-anthropized environment In most contexts, 'natural' is defined by the lack of intervention or influence by humans and their activities. On Earth, most environments fall on a scale between completely natural and anthropised. natural environment A process during which a natural environmental system is altered by human action. anthropization An area may be classified as anthropized even though it looks natural, such as grasslands that have been deforested by humans. It can be difficult to determine how much a site has been anthropized in the case of urbanization because one must be able to estimate the state of the landscape before significant human action. anthropisation A part of an astronomical body which includes, as parts, all the entities which have been constructed or manufactured by humans or their technology and which are within the gravitational sphere of influence of that body. An environmental system which includes, as parts, all the entities which have been constructed or manufactured by humans or their technology within the gravitational sphere of influence of an astronomical body. envoAstro The gravitational sphere of influence referenced in this class' definition is the Hill sphere: a region in which an object dominates the attraction of satellites despite gravitational perturbations. technosphere A planned process during which raw or recycled materials are transformed into products for use or sale using labour and machines, tools, chemical and biological processing, or formulation. The term may refer to a range of human activity, from handicraft to high tech, but is most commonly applied to industrial production, in which raw materials are transformed into finished goods on a large scale. manufacturing process An process during which natural or manufactured materials and products are processed and arranged by humans or their technology into structures. The nature of "structures" must be further specified. construction process An environmental system which includes both living and non-living components. LTER:173 This class will be primarily filled by inference, any environmental system which necessarily includes living parts should be autoclassified here. ecosystem A quality which inheres in a astronomical body or astronomical body part by virtue of the variation in its material composition, participation in geological processes, and the variation in is land- and hydroforms. Materials which are usually assessed when appraising geodiversity include minerals, rocks, sediments, fossils, soils and water. Landforms factored into geodiversity metrics typically include folds, faults, and other expressions of morphology or relations between units of earth material. Natural processes that are included in measures of geodiversity are those which either maintain or change materials or geoforms, including tectonics, sediment transport, and pedogenesis. Geodiversity does not usually factor in anthropogenic entities. geodiversity A process during which an ecosystem, its parts, or the processes it participates in are modified by human intervention to accomplish an objective. ecosystem management Umweltmaßnahme environmental management active ecosystem management process A process during which an ecosystem - natural or anthropised - is changed by the actions of humans. http://orcid.org/0000-0002-4366-3088 anthropogenic ecosystem conversion process A planned process during which humans access and obtain resources, benefits, or services from a natural or anthropised ecosystem. http://orcid.org/0000-0002-4366-3088 planned environmental usage process A planned environmental usage process during which an environment supports the settlement and dwelling of a community of humans. http://orcid.org/0000-0002-4366-3088 residential This class does not include environments which are primarily used for commerce or industry. usage of an environment for residential activity A building which is primarily used for the long-term habitation of humans. http://orcid.org/0000-0002-4366-3088 2018-10-04T14:04:49Z domestic building A process in which includes the components of an environmental system as participants. This is a convenience class for organisation and should not be used for annotation. environmental system process A process during which humans apply technology to alter the magnitude, duration, rate, or impact of an environmental process. Relabel the obo foundry unique label to be generic process anthropogenic modulatory intervention process An environmental process which is driven by the action of humans. anthropogenic environmental process A process during which material is displaced from its original location and transported either to a new location or back to the original location. http://orcid.org/0000-0002-3410-4655 http://orcid.org/0000-0002-4366-3088 envoPolar Experimental class for structural purposes not recommended for annotation. material transport process A process during which a portion of some environmental material is converted into a different material or a collection of materials. A different material transformation process class (or similarly named class) pertaining to the conversion of a specific chemical into another belongs in CHEBI and or REX ontologies. http://orcid.org/0000-0002-3410-4655 http://orcid.org/0000-0002-4366-3088 envoPolar Experimental class for structural purposes not recommended for annotation. A material transformation process only refers to ENVO:environmental material classes (e.g. bulk and typically impure substances), rather than transformations converting a specific chemical into another. material transformation process immunoglobulin complex A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. immunoglobulin complex B cell receptor complex An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. B cell receptor complex protein-containing complex A ribosome is a protein complex. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. protein complex protein-containing complex T cell receptor complex A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. T cell receptor complex immunoglobulin complex, circulating An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. antibody antibody immunoglobulin complex, circulating A phenotypic abnormality. Phenotypic abnormality An abnormality of the conjunctiva. Abnormal conjunctiva morphology The presence of chronic increased pressure in the systemic arterial system. Hypertension Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD). Osteoporosis Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces. Eczematoid dermatitis Accumulation of fluid in the peritoneal cavity (between the layers of the peritoneum that lines the abdomen). Ascites Any abnormality of the cardiovascular system. Abnormality of the cardiovascular system Body temperature elevated above the normal range. Fever A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter. Gastroesophageal reflux Lack of desire to eat (loss of appetite). Anorexia An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles. Abnormality of the respiratory system Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale. Dyspnea Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve. Headache Abnormal feeling of sleepiness or difficulty staying awake. Drowsiness An abnormality of the vasculature. Abnormality of the vasculature Enlarged and tortuous veins. Varicose veins Abnormal function of the respiratory system. Abnormal respiratory system physiology An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute. Atrial fibrillation Stridor is a high pitched sound resulting from turbulent air flow in the upper airway. Stridor An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg. Pedal edema Abnormal functionality of the cardiovascular system. Abnormal cardiovascular system physiology Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both. Arrhythmia An infection of the upper or lower respiratory tract. Respiratory tract infection An anomaly in the processes involved in the maintenance of an internal equilibrium. Abnormal homeostasis Edema (swelling) of the bulbar conjunctiva. Chemosis A functional anomaly of the nervous system. Abnormal nervous system physiology Abnormal functionality of the gastrointestinal tract. Functional abnormality of the gastrointestinal tract A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. Cough Abnormal vascular morphology Abnormality of the digestive system A functional anomaly of the digestive system. Abnormality of digestive system physiology Abnormality of vascular function. Abnormal vascular physiology A high-pitched whistling sound associated with labored breathing. Wheezing An anomalous (adventitious) sound produced by the breathing process. Abnormal breath sound Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position. Crackles Abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds. Rhonchi Increased jugular venous pressure. Elevated jugular venous pressure Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease. Conjunctival icterus measurement unit label Examples of measurement unit labels are liters, inches, weight per volume. A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure. 2009-03-16: provenance: a term measurement unit was proposed for OBI (OBI_0000176) , edited by Chris Stoeckert and Cristian Cocos, and subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definition of this, different, term. 2009-03-16: review of this term done during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI. PERSON: Alan Ruttenberg PERSON: Melanie Courtot measurement unit label objective specification In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction. A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved. 2009-03-16: original definition when imported from OBI read: "objective is an non realizable information entity which can serve as that proper part of a plan towards which the realization of the plan is directed." 2014-03-31: In the example of usage ("In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction") there is a protocol which is the ChIP assay protocol. In addition to being concretized on paper, the protocol can be concretized as a realizable entity, such as a plan that inheres in a person. The objective specification is the part that says that some protein and DNA interactions are identified. This is a specification of a process endpoint: the boundary in the process before which they are not identified and after which they are. During the realization of the plan, the goal is to get to the point of having the interactions, and participants in the realization of the plan try to do that. Answers the question, why did you do this experiment? PERSON: Alan Ruttenberg PERSON: Barry Smith PERSON: Bjoern Peters PERSON: Jennifer Fostel goal specification OBI Plan and Planned Process/Roles Branch OBI_0000217 objective specification Pour the contents of flask 1 into flask 2 A directive information entity that describes an action the bearer will take. Alan Ruttenberg OBI Plan and Planned Process branch action specification datum label A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label http://www.golovchenko.org/cgi-bin/wnsearch?q=label#4n GROUP: IAO 9/22/11 BP: changed the rdfs:label for this class from 'label' to 'datum label' to convey that this class is not intended to cover all kinds of labels (stickers, radiolabels, etc.), and not even all kind of textual labels, but rather the kind of labels occuring in a datum. datum label model number A model number is an information content entity specifically borne by catalogs, design specifications, advertising materials, inventory systems and similar that is about manufactured objects of the same class. The model number is an alternative term for the class. The manufactered objects may or may not also bear the model number. Model numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots. manufactered items may have more than one model number, sometimes by rebranding, or because companies are sold and the products issued new model numbers Person: Alan Ruttenberg model number data item Data items include counts of things, analyte concentrations, and statistical summaries. An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers. 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum. 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym. 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/ JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief PERSON: Alan Ruttenberg PERSON: Chris Stoeckert PERSON: Jonathan Rees data data item symbol a serial number such as "12324X" a stop sign a written proper name such as "OBI" An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity. 20091104, MC: this needs work and will most probably change 2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://code.google.com/p/information-artifact-ontology/issues/detail?id=154). 2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154). PERSON: James A. Overton PERSON: Jonathan Rees based on Oxford English Dictionary symbol numeral A symbol that denotes a number. PERSON: Jonathan Rees numeral information content entity Examples of information content entites include journal articles, data, graphical layouts, and graphs. A generically dependent continuant that is about some thing. 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ). information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity. PERSON: Chris Stoeckert OBI_0000142 information content entity information content entity integer numeral a numeral that denotes an integer PERSON: Jonathan Rees integer numeral 1 1 10 feet. 3 ml. a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label. 2009-03-16: we decided to keep datum singular in scalar measurement datum, as in this case we explicitly refer to the singular form Would write this as: has_part some 'measurement unit label' and has_part some numeral and has_part exactly 2, except for the fact that this won't let us take advantage of OWL reasoning over the numbers. Instead use has measurment value property to represent the same. Use has measurement unit label (subproperty of has_part) so we can easily say that there is only one of them. PERSON: Alan Ruttenberg PERSON: Melanie Courtot scalar measurement datum An information content entity whose concretizations indicate to their bearer how to realize them in a process. 2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was "is the specification of a process that can be concretized and realized by an actor" with alternative term "instruction".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term. 2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it. 8/6/2009 Alan Ruttenberg: Changed label from "information entity about a realizable" after discussions at ICBO Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan PERSON: Alan Ruttenberg PERSON: Bjoern Peters directive information entity dot plot Dot plot of SSC-H and FSC-H. A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions. person:Allyson Lister person:Chris Stoeckert OBI_0000123 group:OBI dot plot graph A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way. PERSON: Lawrence Hunter person:Alan Ruttenberg person:Allyson Lister OBI_0000240 group:OBI graph contour plot Contour plot of SSC-H, FSC-H, and FL1-H. generically_dependent_continuants person:Allyson Lister person:Chris Stoeckert OBI_0000246 group:Flow Cytometry community contour plot curation status specification The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting) PERSON:Bill Bug GROUP:OBI:<http://purl.obolibrary.org/obo/obi> OBI_0000266 curation status specification density plot Density plot of SSC-H and FSC-H. A density plot is a report graph which is a graphical representation of data where the tint of a particular pixel corresponds to some kind of function corresponding the the amount of data points relativelly with their distance from the the pixel. person:Allyson Lister person:Chris Stoeckert OBI_0000179 group:Flow Cytometry community density plot data set Intensity values in a CEL file or from multiple CEL files comprise a data set (as opposed to the CEL files themselves). A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets. 2009/10/23 Alan Ruttenberg. The intention is that this term represent collections of like data. So this isn't for, e.g. the whole contents of a cel file, which includes parameters, metadata etc. This is more like java arrays of a certain rather specific type 2014-05-05: Data sets are aggregates and thus must include two or more data items. We have chosen not to add logical axioms to make this restriction. person:Allyson Lister person:Chris Stoeckert OBI_0000042 group:OBI data set image An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface. person:Alan Ruttenberg person:Allyson person:Chris Stoeckert OBI_0000030 group:OBI image data about an ontology part Data about an ontology part is a data item about a part of an ontology, for example a term data about an ontology part is a data item about a part of an ontology, for example a term Person:Alan Ruttenberg Person:Alan Ruttenberg data about an ontology part plan specification PMID: 18323827.Nat Med. 2008 Mar;14(3):226.New plan proposed to help resolve conflicting medical advice. A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. 2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was " a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan". It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term. 2014-03-31: A plan specification can have other parts, such as conditional specifications. Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved Alan Ruttenberg OBI Plan and Planned Process branch OBI_0000344 2/3/2009 Comment from OBI review. Action specification not well enough specified. Conditional specification not well enough specified. Question whether all plan specifications have objective specifications. Request that IAO either clarify these or change definitions not to use them plan specification measurement datum Examples of measurement data are the recoding of the weight of a mouse as {40,mass,"grams"}, the recording of an observation of the behavior of the mouse {,process,"agitated"}, the recording of the expression level of a gene as measured through the process of microarray experiment {3.4,luminosity,}. A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device. 2/2/2009 is_specified_output of some assay? person:Chris Stoeckert OBI_0000305 group:OBI measurement datum version number A version number is an information content entity which is a sequence of characters borne by part of each of a class of manufactured products or its packaging and indicates its order within a set of other products having the same name. Note: we feel that at the moment we are happy with a general version number, and that we will subclass as needed in the future. For example, see 7. genome sequence version GROUP: IAO version number serial number A serial number is an information content entity which is a unique sequence of characters borne by part of manufactured product or its packaging that is assigned to each individual in some class of products, and so can serve as a way to identify an individual product within the class. Serial numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots. Note: during the call there was some confusion between serial number and model number. We agreed that it would be very helpful for all those terms to have example of usages - please add if you have any :-) GROUP: IAO serial number lot number A lot number is an information content entity which is an identical sequence of character borne by part of manufactured product or its packaging for each instances of a product class in a discrete batch of an item. Lot numbers are usually assigned to each separate production run of an item. Manufacturing as a lot might be due to a variety of reasons, for example, a single process during which many individuals are made from the same portion of source material. Lot numbers can be encoded in a pattern of other information objects, such as bar codes, numerals, or patterns of dots. GROUP: IAO batch number lot number histogram A histogram is a report graph which is a statistical description of a distribution in terms of occurrence frequencies of different event classes. PERSON:Chris Stoeckert PERSON:James Malone PERSON:Melanie Courtot GROUP:OBI histogram heatmap A heatmap is a report graph which is a graphical representation of data where the values taken by a variable(s) are shown as colors in a two-dimensional map. PERSON:Chris Stoeckert PERSON:James Malone PERSON:Melanie Courtot GROUP:OBI heatmap Venn diagram A Venn diagram is a report graph showing all hypothetically possible logical relations between a finite collection of sets. PERSON:Chris Stoeckert PERSON:James Malone PERSON:Melanie Courtot WEB: http://en.wikipedia.org/wiki/Venn_diagram Venn diagram dendrogram Dendrograms are often used in computational biology to illustrate the clustering of genes. A dendrogram is a report graph which is a tree diagram frequently used to illustrate the arrangement of the clusters produced by a clustering algorithm. PERSON:Chris Stoeckert PERSON:James Malone PERSON:Melanie Courtot WEB: http://en.wikipedia.org/wiki/Dendrogram dendrogram scatter plot Comparison of gene expression values in two samples can be displayed in a scatter plot A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis. PERSON:Chris Stoeckert PERSON:James Malone PERSON:Melanie Courtot scattergraph WEB: http://en.wikipedia.org/wiki/Scatterplot scatter plot A photograph is created by projecting an image onto a photosensitive surface such as a chemically treated plate or film, CCD receptor, etc. PERSON:Alan Ruttenberg PERSON:Joanne Luciano PERSON:Melanie Courtot WEB: http://en.wiktionary.org/wiki/photograph photograph textual entity Words, sentences, paragraphs, and the written (non-figure) parts of publications are all textual entities A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc. AR, (IAO call 2009-09-01): a document as a whole is not typically a textual entity, because it has pictures in it - rather there are parts of it that are textual entities. Examples: The title, paragraph 2 sentence 7, etc. MC, 2009-09-14 (following IAO call 2009-09-01): textual entities live at the FRBR (http://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records) manifestation level. Everything is significant: line break, pdf and html versions of same document are different textual entities. PERSON: Lawrence Hunter text textual entity citation Verspoor, K., Cohen, KB., Hunter, L. Textual characteristics of traditional and Open Access scientific journals are similar, BMC Bioinformatics 2009, 10:183. a textual entity intended to identify a particular publication PERSON: Lawrence Hunter citation document title Textual characteristics of traditional and Open Access scientific journals are similar A textual entity that names a document PERSON: Lawrence Hunter document title table | T F --+----- T | T F F | F F A textual entity that contains a two-dimensional arrangement of texts repeated at regular intervals across a spatial range, such that the spatial relationships among the constituent texts expresses propositions PERSON: Lawrence Hunter table figure Any picture, diagram or table An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something. PERSON: Lawrence Hunter figure diagram A molecular structure ribbon cartoon showing helices, turns and sheets and their relations to each other in space. A figure that expresses one or more propositions PERSON: Lawrence Hunter diagram document A journal article, patent application, laboratory notebook, or a book A collection of information content entities intended to be understood together as a whole PERSON: Lawrence Hunter document hypothesis textual entity that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper 'Pilot clinical study to evaluate the anticoagulant activity of fucoidan', by Lowenthal et. al.PMID:19696660 A textual entity that expresses an assertion that is intended to be tested. 2009/09/28 Alan Ruttenberg. Fucoidan-use-case Person:Alan Ruttenberg hypothesis textual entity A scalar measurement datum that is the result of measuring a temporal interval 2009/09/28 Alan Ruttenberg. Fucoidan-use-case Person:Alan Ruttenberg time measurement datum A textual entity that is used as directive to deliver something to a person, or organization 2010-05-24 Alan Ruttenberg. Use label for the string representation. See issue https://github.com/information-artifact-ontology/IAO/issues/59 postal address email address Alan Ruttenberg 1/3/2012 - Provisional id, see issue at https://github.com/information-artifact-ontology/IAO/issues/130&thanks=130&ts=1325636583 Person:Alan Ruttenberg Person:Chris Stoeckart email address Recording the current temperature in a laboratory notebook. Writing a journal article. Updating a patient record in a database. A planned process in which a document is created or added to by including the specified input in it. a planned process in which a document is created or added to by including the specified input in it. 6/11/9: Edited at OBI workshop. We need to be able identify a child form of information artifact which corresponds to something enduring (not brain like). This used to be restricted to physical document or digital entity as the output, but that excludes e.g. an audio cassette tape Bjoern Peters wikipedia http://en.wikipedia.org/wiki/Documenting documenting line graph A line graph is a type of graph created by connecting a series of data points together with a line. PERSON:Chris Stoeckert PERSON:Melanie Courtot line chart GROUP:OBI WEB: http://en.wikipedia.org/wiki/Line_chart line graph A new pubmed ID being created for a journal article, and the associated pubmed record containing information to the journal article. A license plate number registered at the DMV to be belonging to a specific vehicle and owner. Placing a barcode on a product and entering information in a database that this barcode is assigned. A planned process in which a new CRID is created, associated with an entity, and stored in the CRID registry thereby registering it as being associated with some entity 2014-05-05: It is the CRID registry that assigns CRIDs, not the users of the registry. Person:Alan Ruttenberg Person:Bjoern Peters Person:Melanie Courtot assigning a CRID assigning a centrally registered identifier The sentence "The article has Pubmed ID 12345." contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed. A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry. PERSON: Alan Ruttenberg PERSON: Bill Hogan PERSON: Bjoern Peters PERSON: Melanie Courtot CRID symbol Original proposal from Bjoern, discussions at IAO calls centrally registered identifier symbol Entries in a Column of which the header is "Pubmed ID" PMID:12345 The following URL: "http://www.ncbi.nlm.nih.gov/pubmed/19918065" The following sentence contains a CRID: "The article with Pubmed ID: 19918065". The sentence "The article has Pubmed ID 12345." contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed. An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs. An information content entity that consists of a CRID symbol and additional information about which CRID registry it belongs. 2014-05-05: In defining this term we take no position on what the CRID denotes. In particular do not assume it denotes a *record* in the CRID registry (since the registry might not have 'records'). Alan, IAO call 20101124: potentially the CRID denotes the instance it was associated with during creation. Note, IAO call 20101124: URIs are not always CRID, as not centrally registered. We acknowledge that CRID is a subset of a larger identifier class, but this subset fulfills our current needs. OBI PURLs are CRID as they are registered with OCLC. UPCs (Universal Product Codes from AC Nielsen)are not CRID as they are not centrally registered. PERSON: Alan Ruttenberg PERSON: Bill Hogan PERSON: Bjoern Peters PERSON: Melanie Courtot CRID Centrally Registered IDentifier Original proposal from Bjoern, discussions at IAO calls http://purl.obolibrary.org/obo/iao.owl CRID centrally registered identifier PubMed is a CRID registry. It has a dataset of PubMed identifiers associated with journal articles. A CRID registry is a dataset of CRID records, each consisting of a CRID symbol and additional information which was recorded in the dataset through a assigning a centrally registered identifier process. PERSON: Alan Ruttenberg PERSON: Bill Hogan PERSON: Bjoern Peters PERSON: Melanie Courtot CRID registry Original proposal from Bjoern, discussions at IAO calls centrally registered identifier registry written name "Bill Clinton" "The Eiffel Tower" "United States of America" A textual entity that denotes a particular in reality. PERSON: Bill Hogan https://github.com/information-artifact-ontology/IAO/issues/114 The qualifier "written" is to set it apart from spoken names. Also, note the restrictions to particulars. We are not naming universals. We could however, be naming, attributive collections which are particulars, so "All people located in the boundaries of the city of Little Rock, AR on June 18, 2011 at 9:50a CDT" would be a name. written name author information textual entity From Takon. Ann Gen Psychiatry. 2011; 10: 25. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204268/): IT [the author] is the lead paediatrician for ADHD services in East Hertfordshire, UK, where she runs a weekly joint ADHD clinic with the Child and Adolescent psychiatrist and works within an ADHD specialist team. IT also sees children with other neurodisability issues who may have comorbid ADHD, where the presentation may be more complex and challenging to manage. IT has vast experience in managing children with complex ADHD. She has 18 years of experience in paediatrics and also has extensive experience in the use of psychopharmacologic agents in managing children with ADHD. A textual entity expression information about an author of a document. This information may include biographical information and may discuss how the authors' professional experiences are relevant to the work described in the document. PERSON: Bill Baumgartner author information textual entity case report textual entity Excerpt from Taglia et al. Acta Myol. 2012 Dec; 31(3): 201–203. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631801/): The patient is a 50-year-old man. His medical history was not contributory. At the age of 37 years, he complained of persistent fatigue and dyspnoea even for modest efforts and oedema of lower limbs. The patient was examined at the department of internal medicine of the local hospital, and hospitalised with a diagnosis of dilated cardiomyopathy probably consequence of a myocarditis process. Soon after he was transferred to the cardiologic department of the regional hospital, and pharmacologically treated for heart failure and pulmonary hypertension. A textual entity that expresses a detailed account of a portion of the medical history for a specific patient. PERSON: Bill Baumgartner case report textual entity Colonel Klink giving Sergeant Schultz an order, Jake promising Jill to take her to the junior prom A planned process that is carried out by a conscious being or an organization, and is self-generated, directed towards another conscious being or an aggregate of conscious beings, an organization or an aggregate of organizations, and that needs to be perceived. A process that is carried out by a conscious being or an aggregate of conscious beings and is spontaneous, directed towards other conscious beings and aggregates thereof and needs to be perceived. Mathias Brochhausen MB: Regarding the use of the term 'sponteneous' in the definition: The term is used in the following meaning of being self generated. It does not stand in contrast to being planned. social act the claim of a piece of land, the obligation to pay rent to the owner of a rental property Socio-legal generically dependent continuants are generically dependent continuants that come into existence through declarations and are concretized as roles. They differ from information content entities in that they are not about something, but exist as quasi-abstract social entities. Socio-legal generically dependent continuants are not concretized as qualities inhering in independent continuants, but only as realizable entities borne by an organism or an aggregate of organisms. Mathias Brochhausen socio-legal generically dependent continuant my consenting verbally to buy a used TV set for $ 500, Jane Doe's signing of the divorce papers, John Robie's taking of Mrs. Steven's jewels A social act that brings about, transfers or revokes a socio-legal generically dependent continuant or brings about or revokes a role. Declarations do not depend on words spoken or written, but sometimes are merely actions, for instance the signing of a document. Mathias Brochhausen declaration A document that is intended to be the specified input in a document act. It has a plan specification as a part that specifies the intended socio-legal entities that are created through the document (objective specification) and the way in which the document act is to be performed (by signing, by stamping, etc.) (action specification). Mathias Brochhausen document act input document a judge's role of signing a court order, a hospital committee's to sanction conformance to a specific guideline for hospital employees. A role inhering in a human being or an organization or an aggregate of any of the aforementioned that is realized by the bearer being the agent in a declaration. Mathias Brochhausen declaration performer role A document that explains all relevant information to assist a human being in understanding the expectations and requirements of participation in a process, and is an instrument in obtaining consent and, after having obtained consent, is a record that such a consent has occurred. The term definition is adapted from NCIt definition of 'consent form' (C16468) with modification. For instance, whereas the NCIt definition restricted informed consent forms to clinical trials, the present definition does not. Alla Karnovsky, Frank Manion, Yongqun He, Asiyah Yu Lin, Marcy Harris, Elizabeth Eisenhauer, Jonathan Vajda, Cooper Stansbury, J. Neil Otte informed consent document NCIt C16468 See curator note for 'incomplete informed consent form'. C0009797 C16468 informed consent form A social act that is a part of an informed consent process and has output of a signed informed consent form. The signing process leads to a legal obligation. Alla Karnovsky, Frank Manion, Yongqun He, Jihad Obeid, Chris Stoeckert, and Mathias Brochhausen This class is under group discussion as of 03/26/2019. Signing here does not mean that we have to sign with a pen. It may happen in terms of signing a piece of a paper or an electronic form. signing an informed consent form A document act input document that explains all relevant information to assist a human being in understanding the expectations and requirements of participation in a process, and whose purpose is to assist in obtaining consent. J. Neil Otte Note: instances of 'incomplete informed consent form' include both blank informed consent forms that are waiting to be used in a process of informed consent, as well as those that have been left blank by a patient, whether on purpose or in error. Those that have been left blank on purpose have been used in a process of informed consent, where the patient must have reached a decision. incomplete informed consent form A document act input document that has, as part, an incomplete informed consent form, along with some additional parts, such as a signature, stamp, or initials, which serve as a record to an act of consent that had the incomplete informed consent form as a specified input. J. Neil Otte complete informed consent form indicating consent An information content entity that is a handwritten depiction of a name. Jonathan Vajda, Cooper Stansbury, J. Neil Otte. signature Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.Signs and symptomsmay be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may includepersonality or moodchanges, intellectual impairment, abnormal movements,a depressed level of consciousness, and other symptoms.There are several theories regarding the exact cause, butdevelopment of the condition isprobablyat least partiallydue to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis. https://www.malacards.org/card/hepatic_encephalopathy DOID:13413 GARD:0027587 ICD9:572.2 MEDGEN:5513 MESH:D006501 NCIT:C79596 SCTID:13920009 UMLS:C0019151 icd11.foundation:1769383160 portal-systemic encephalopathy Hepatoencephalopathy encephalopathy, hepatic MONDO:0001711 hepatic encephalopathy https://rarediseases.info.nih.gov/diseases/10452/hepatic-encephalopathy A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma. EFO:0003769 ICD9:239.7 MEDGEN:4044 NCIT:C3010 SCTID:387922007 UMLS:C0014132 endocrine gland neoplasm (disease) endocrine gland tumor endocrine gland tumour endocrine neoplasm endocrine system neoplasm endocrine system tumor endocrine system tumour endocrine tumor endocrine tumour neoplasm of endocrine gland tumor of endocrine gland tumour of endocrine gland malignant endocrine tumor malignant endocrine tumour MONDO:0002082 endocrine gland neoplasm A non-neoplastic or neoplastic disorder that affects the pancreas. Representative examples of non-neoplastic disorders include pancreatitis and pancreatic insufficiency. Representative examples of neoplastic disorders include cystadenomas, carcinomas, lymphomas, and neuroendocrine neoplasms. https://www.malacards.org/card/pancreas_disease DOID:26 EFO:0009605 ICD10CM:K86.9 ICD9:577.8 ICD9:577.9 MEDGEN:14583 MESH:D010182 NCIT:C26842 SCTID:3855007 UMLS:C0030286 icd11.foundation:1726554290 disease of pancreas disease or disorder of pancreas disorder of pancreas pancreas disease pancreas disease or disorder pancreatic disorder disease, pancreatic diseases, pancreatic pancreatic disease MONDO:0002356 pancreas disorder An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis. https://www.malacards.org/card/dermatitis DOID:2723 ICD9:692.9 MEDGEN:849741 MESH:D003872 NCIT:C2983 SCTID:43116000 UMLS:C3875321 inflammation of skin inflammation of the skin inflammation of zone of skin inflammatory skin disease skin inflammation zone of skin inflammation MONDO:0002406 dermatitis Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria. https://github.com/monarch-initiative/mondo/issues/9613 https://www.malacards.org/card/acute_kidney_failure DOID:3021 ICD10CM:N17 MEDGEN:388570 MESH:D058186 NCIT:C26808 UMLS:C2609414 icd11.foundation:476391827 AKI ARF acute kidney failure acute renal failure kidney failure, acute MONDO:0002492 acute kidney injury A benign or malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples of benign neoplasms include hepatocellular adenoma, bile duct adenoma, and gallbladder lipoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma. DOID:0080355 EFO:0008550 MEDGEN:208891 NCIT:C8614 UMLS:C0854196 hepatic and biliary neoplasms hepatic and biliary tumors hepatic and biliary tumours hepatic, biliary, and gallbladder neoplasms hepato-biliary neoplasm hepato-biliary tumor hepato-biliary tumour hepatobiliary neoplasm hepatobiliary system neoplasm hepatobiliary system neoplasm (disease) hepatobiliary system tumor hepatobiliary system tumour hepatobiliary tumor hepatobiliary tumors hepatobiliary tumour hepatobiliary tumours liver and biliary neoplasm liver and biliary system neoplasm neoplasm of hepatobiliary system tumor of hepatobiliary system tumour of hepatobiliary system hepatobiliary benign neoplasm MONDO:0002514 hepatobiliary neoplasm A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma. DOID:3118 EFO:0010284 MEDGEN:82758 NCIT:C3959 UMLS:C0267792 disease of hepatobiliary system disease or disorder of hepatobiliary system disorder of hepatobiliary system hepatobiliary disorder hepatobiliary system disease hepatobiliary system disease or disorder liver and biliary disease liver and biliary disorder liver and biliary system disorder MONDO:0002515 hepatobiliary disorder A primary or metastatic malignant neoplasm involving any part of the digestive system. https://www.malacards.org/card/gastrointestinal_system_cancer GI tumor GI tumour DOID:3119 ICD10CM:C15-C26 ICD9:239.0 MEDGEN:148231 NCIT:C4890 UMLS:C0751075 cancer of digestive system digestive system cancer gastrointestinal system cancer malignant digestive system neoplasm malignant gastrointestinal neoplasm malignant gastrointestinal system neoplasm malignant neoplasm of digestive system MONDO:0002516 digestive system cancer An inherited metabolic disorder caused by an enzyme deficiency, resulting in an inability to oxidize fatty acids for energy production. https://www.malacards.org/card/lipid_metabolism_disorder disorder of lipid metabolism dyslipidaemia dyslipidemia lipid metabolism disorder DOID:3146 GARD:0021314 ICD9:272.8 ICD9:272.9 MEDGEN:57587 MedDRA:10061227 NCIT:C97092 Orphanet:309005 SCTID:267431006 SCTID:402788005 UMLS:C0154251 MONDO:0002525 inherited lipid metabolism disorder An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma. https://www.malacards.org/card/hepatocellular_carcinoma DOID:3571 GARD:0027613 ICD9:155.0 ICD9:155.2 MEDGEN:87520 NCIT:C34803 SCTID:93870000 UMLS:C0345904 icd11.foundation:1605020868 cancer of liver hepatic cancer liver cancer malignant liver neoplasm malignant neoplasm of liver malignant neoplasm of liver, not specified as primary or secondary malignant neoplasm of liver, primary malignant tumour of liver primary liver cancer primary malignant liver neoplasm primary malignant neoplasm of liver primary cancer of liver primary tumor of the liver primary tumour of the liver MONDO:0002691 liver cancer A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome. genetic condition genetic disease genetic disorder DOID:630 EFO:0000508 ICD9:799.89 MEDGEN:5527 MESH:D030342 NCIT:C3101 SCTID:32895009 UMLS:C0019247 hereditary disease hereditary disease or disorder hereditary diseases inherited disease inherited genetic disease molecular disease Mendelian disease MONDO:0003847 Usage note: this is intended only for diseases with an inherited genetic etiology. Somatic genetic mutations are excluded. Some ontologies use the term 'genetic disease' in the sense of inherited disorders only, we are here careful to distinguish. hereditary disease A disease or disorder that involves the digestive system. https://www.malacards.org/card/gastrointestinal_system_disease DOID:77 ICD10CM:K00-K95 ICD9:520-579 ICD9:V47.3 MEDGEN:892790 MESH:D005767 NANDO:1100013 NCIT:C2990 SCTID:53619000 UMLS:C4023588 icd11.foundation:1256772020 digestive disease digestive system disease digestive system disease or disorder digestive system disorder disease of digestive system disease or disorder of digestive system disorder of digestive system gastroenterological system disease gastroenterological system disorder gastrointestinal disorder gastrointestinal system disease gastrointestinal system disorder stomach or intestinal disorder MONDO:0004335 digestive system disorder A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. https://www.malacards.org/card/adenocarcinoma CSP:2000-0386 DOID:299 EFO:0000228 ICDO:8140/3 MEDGEN:122 MESH:D000230 NCIT:C2852 ONCOTREE:ADNOS SCTID:443961001 UMLS:C0001418 adenocarcinoma adenocarcinoma NOS (morphologic abnormality) adenocarcinoma, malignant adenocarcinoma, no subtype (morphologic abnormality) adenocarcinomas ADNOS MONDO:0004970 adenocarcinoma A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. https://www.malacards.org/card/cell_type_cancer DOID:0050686 DOID:0050687 DOID:162 ICD9:195.8 ICD9:199 ICD9:199.1 ICDO:8000/3 MEDGEN:14297 NCIT:C9305 ONCOTREE:MT SCTID:363346000 UMLS:C0006826 birnlex:406 CA cancer cell type cancer malignancy malignant growth malignant neoplasm malignant neoplasm (disease) malignant neoplastic disease malignant tumor malignant tumour neoplasm (disease), malignant neoplasm, malignant MT MONDO:0004992 cancer A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas. epithelioma CSP:2000-1867 DOID:305 EFO:0000313 ICDO:8010/3 ICDO:8011/3 MEDGEN:2867 MESH:D002277 NCIT:C2916 SCTID:722688002 UMLS:C0007097 Other carcinoma carcinoma carcinoma, malignant epithelial carcinoma epithelioma malignant malignant epithelial neoplasm malignant epithelial tumor malignant epithelial tumour malignant epithelioma MONDO:0004993 carcinoma A disease involving the cardiovascular system. https://www.malacards.org/card/cardiovascular_system_disease DOID:1287 EFO:0000319 ICD10CM:I00-I99 ICD9:390-459 ICD9:420-429 ICD9:423 ICD9:423.8 ICD9:424 ICD9:429 ICD9:429.2 ICD9:429.7 ICD9:429.8 ICD9:429.81 ICD9:429.89 ICD9:459.89 ICD9:459.9 MEDGEN:2848 MESH:D002318 NANDO:1100005 NCIT:C2931 SCTID:49601007 UMLS:C0007222 icd11.foundation:424293435 icd11.foundation:426429380 cardiovascular disease cardiovascular disease (CVD) cardiovascular disorder cardiovascular system disease cardiovascular system disease or disorder disease of cardiovascular system disease or disorder of cardiovascular system disorder of cardiovascular system circulatory system disease MONDO:0004995 cardiovascular disorder A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization. https://github.com/monarch-initiative/mondo/issues/5723 diabetes mellitus (disease) https://www.malacards.org/card/diabetes_mellitus DOID:9351 EFO:0000400 HP:0000819 ICD10CM:E08-E13 ICD10WHO:E10-E14 ICD9:250 MEDGEN:8350 MESH:D003920 NANDO:2100157 NANDO:2100158 NCIT:C2985 SCTID:73211009 UMLS:C0011849 icd11.foundation:465177735 DM diabetes diabetes mellitus diabetes mellitus (disease) MONDO:0005015 diabetes mellitus Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis. EFO:0000401 ICD9:250.4 ICD9:250.40 ICD9:583.81 MEDGEN:8352 MESH:D003928 NCIT:C84417 SCTID:127013003 UMLS:C0011881 icd11.foundation:615062102 DKD diabetic nephropathy type 1 diabetes nephropathy type 2 diabetes nephropathy MONDO:0005016 diabetic kidney disease A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process. DOID:0014667 EFO:0000589 ICD10CM:E70-E88 ICD10WHO:E70-E90 ICD9:277.8 ICD9:277.9 MEDGEN:44376 MESH:D008659 NANDO:1100002 NCIT:C3235 SCTID:75934005 UMLS:C0025517 disorder of metabolic process metabolic disease metabolic disorder metabolic process disease MONDO:0005066 metabolic disease A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. neoplasm (disease) cell process disease DOID:14566 EFO:0000616 HP:0002664 ICD10CM:C00-D49 ICD10CM:C7A-C7A ICD10CM:C7B-C7B ICD9:140-239 ICD9:239.8 ICD9:239.9 MEDGEN:10294 MESH:D009369 NCIT:C3262 ONCOTREE:OTHER SCTID:55342001 UMLS:C0027651 disease of cellular proliferation neoplasia neoplasm neoplasm (disease) neoplastic disease neoplastic growth tumor tumor disease tumour tumour disease other neoplasm MONDO:0005070 neoplasm An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp. https://www.malacards.org/card/psoriasis DOID:8893 EFO:0000676 ICD10CM:L40 ICD10WHO:L40 ICD9:696 ICD9:696.1 ICD9:696.5 ICD9:696.8 MEDGEN:10997 MESH:D011565 NCIT:C3346 OMIMPS:177900 SCTID:9014002 UMLS:C0033860 icd11.foundation:63698555 MONDO:0005083 psoriasis Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs. https://www.malacards.org/card/skin_disease DOID:37 EFO:0000701 ICD9:702 ICD9:702.8 ICD9:709.8 MEDGEN:20777 MESH:D012871 NANDO:2100281 NCIT:C3371 SCTID:95320005 UMLS:C0037274 cutaneous disorder disease of zone of skin disease or disorder of zone of skin disorder of skin disorder of zone of skin skin diseases and manifestations skin disorder zone of skin disease zone of skin disease or disorder dermatosis genodermatosis MONDO:0005093 skin disorder A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity. https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/7275 https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/type_2_diabetes_mellitus DOID:9352 ICD10CM:E11 ICD10WHO:E11 MEDGEN:41523 MESH:D003924 NANDO:2200461 NCIT:C26747 OMIM:125853 SCTID:44054006 UMLS:C0011860 icd11.foundation:119724091 NIDDM T2D T2DM T2DM - type 2 diabetes mellitus adult onset diabetes adult-onset diabetes diabetes mellitis type 2 diabetes mellitis type II diabetes mellitus, noninsulin-dependent diabetes mellitus, noninsulin-dependent, association with diabetes mellitus, noninsulin-dependent, late onset diabetes mellitus, type 2 diabetes mellitus, type II diabetes, type 2 insulin resistance, severe, digenic non-insulin dependent diabetes non-insulin dependent diabetes mellitus noninsulin dependent diabetes noninsulin-dependent diabetes mellitus type 2 diabetes type 2 diabetes mellitus type 2 diabetes mellitus non-insulin dependent type II diabetes type II diabetes mellitus diabetes mellitus, noninsulin-dependent, 2 MONDO:0005148 type 2 diabetes mellitus A disease involving the endocrine system. https://www.malacards.org/card/endocrine_system_disease DOID:28 EFO:0001379 ICD9:259.8 ICD9:259.9 MEDGEN:4043 MESH:D004700 NANDO:1100009 NANDO:2100109 NCIT:C3009 SCTID:362969004 UMLS:C0014130 disease of endocrine system disease or disorder of endocrine system disorder of endocrine system endocrine disease endocrine disorder endocrine system disease endocrine system disease or disorder endocrine system disorder endocrinopathy thyroid or other glandular disorders MONDO:0005151 endocrine system disorder A disease involving the liver. https://www.malacards.org/card/liver_disease DOID:409 EFO:0001421 ICD10CM:K70-K77 ICD9:573.8 ICD9:573.9 MEDGEN:893061 MESH:D008107 NCIT:C3196 SCTID:235856003 UMLS:C4021780 icd11.foundation:1784240230 disease of liver disease or disorder of liver disorder of liver hepatic disease hepatic disorder liver and intrahepatic bile duct disorder liver disease liver disease or disorder liver disorder MONDO:0005154 liver disorder A disease involving the kidney. https://www.malacards.org/card/kidney_disease DOID:557 EFO:0003086 ICD9:583.81 MEDGEN:9635 MESH:D007674 NCIT:C3149 SCTID:90708001 UMLS:C0022658 disease of kidney disease or disorder of kidney disorder of kidney kidney disease kidney disease or disorder kidney disorder renal disease renal disorder MONDO:0005240 kidney disorder A disease involving the heart and/or pericardium. https://www.malacards.org/card/heart_disease DOID:114 EFO:0003777 ICD9:429.89 ICD9:429.9 ICD9:V47.2 MEDGEN:5458 MESH:D006331 NCIT:C3079 SCTID:56265001 UMLS:C0018799 icd11.foundation:1512587470 cardiac disease disease of heart disease or disorder of heart disorder of heart disorder of heart/pericardium heart disease heart disease or disorder heart disorder heart trouble heart/pericardial disease heart/pericardial disease or disorder heart/pericardial disorder heart/pericardial trouble MONDO:0005267 heart disorder Impairment of the renal function secondary to chronic kidney damage persisting for three or more months. https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/chronic_kidney_disease DOID:784 EFO:0003884 ICD10CM:N18 ICD10CM:N18.9 ICD10WHO:N18 ICD9:585 MEDGEN:473458 MESH:D007676 NANDO:2100008 NANDO:2100023 NCIT:C80078 SCTID:709044004 UMLS:C1561643 icd11.foundation:412389819 CKD - chronic kidney disease chronic kidney disease chronic renal disease kidney disease, chronic chronic renal failure syndrome MONDO:0005300 chronic kidney disease A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. EFO:0006858 MEDGEN:277963 MESH:D009375 NCIT:C3709 SCTID:118285006 UMLS:C1368683 epithelial neoplasm epithelioma MONDO:0005626 epithelial neoplasm A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma. https://www.malacards.org/card/gastrointestinal_carcinoma DOID:0050922 EFO:1000218 HP:0002672 MEDGEN:57467 NCIT:C96963 UMLS:C0151544 carcinoma of digestive system carcinoma of the gastrointestinal system digestive system carcinoma gastrointestinal carcinoma gastrointestinal carcinoma (disease) gastrointestinal system carcinoma MONDO:0006181 digestive system carcinoma A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/9097 DOID:684 DOID:686 EFO:0000182 GARD:0016773 ICD10CM:C22.0 ICDO:8170/3 MEDGEN:389187 MESH:D006528 MedDRA:10049010 NANDO:2200047 NCIT:C3099 NORD:1907 OMIM:114550 ONCOTREE:HCC Orphanet:88673 UMLS:C2239176 icd11.foundation:1294035808 HCC cancer, hepatocellular carcinoma of liver carcinoma of liver cells carcinoma of the liver cells carcinoma, hepatocellular, malignant hepatoblastoma, somatic hepatocellular adenocarcinoma hepatocellular cancer hepatocellular cancer, somatic hepatocellular carcinoma hepatocellular carcinoma, childhood type, somatic hepatocellular carcinoma, somatic hepatoma liver carcinoma liver cell cancer (hepatocellular carcinoma) liver cell carcinoma primary carcinoma of liver cells primary carcinoma of the liver cells adult hepatoma adult primary hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma A disorder that manifests as multiple cysts on the ovaries. It results in hormonal imbalances and leads to irregular and abnormal menstrual periods, excess growth of hair, acne eruptions and obesity. https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/polycystic_ovary_syndrome https://www.malacards.org/card/polycystic_ovary_syndrome_1 DOID:11612 EFO:0000660 ICD10CM:E28.2 ICD9:256.4 MEDGEN:10836 MESH:D011085 NANDO:2100149 NANDO:2200409 NCIT:C26862 OMIM:184700 Orphanet:3185 SCTID:69878008 UMLS:C0032460 icd11.foundation:1213633323 PCOS Stein-Leventhal syndrome polycystic ovarian disease polycystic ovaries polycystic ovary syndrome PCOS1 polycystic ovary syndrome 1 MONDO:0008487 polycystic ovary syndrome A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma. https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/carcinoma_of_liver_and_intrahepatic_biliary_tract cancer of liver cancer of liver and intrahepatic biliary tract cancer of the liver cancer of the liver and intrahepatic biliary tract carcinoma of liver hepatic cancer liver and intrahepatic bile duct cancer liver cancer liver carcinoma liver/hepatobiliary cancer GARD:0021786 MEDGEN:78921 NCIT:C7927 ONCOTREE:HCCIHCH Orphanet:424936 UMLS:C0279000 carcinoma of liver and IBT liver and intrahepatic bile duct carcinoma liver and intrahepatic biliary tract cancer liver and intrahepatic biliary tract carcinoma primary liver carcinoma hepatocellular carcinoma plus intrahepatic cholangiocarcinoma MONDO:0018531 Editor note: In uberon intrahepatic bile ducts are part of the liver, so we equate this with carcinoma of liver; we use hepatocellular for the liver proper carcinoma of liver and intrahepatic biliary tract An inherited disorder resulting from an enzyme defect in biochemical and metabolic pathways affecting proteins, fats, carbohydrates metabolism or organelle function. https://github.com/monarch-initiative/mondo/issues/1483 https://www.malacards.org/card/inherited_metabolic_disorder DOID:655 GARD:0022508 MEDGEN:6323 MESH:D008661 MedDRA:10058097 MedDRA:10062018 NANDO:2100159 NCIT:C34816 Orphanet:68367 SCTID:86095007 UMLS:C0025521 icd11.foundation:733825440 congenital metabolic disorder congenital metabolism disorder hereditary metabolic disease inborn disorders of metabolism inborn error of metabolism inborn errors of metabolism inborn metabolic disorder inherited disorder of metabolism inherited disorders of metabolism inherited metabolic disorder rare inborn errors of metabolism rare inherited metabolic disorder MONDO:0019052 Note that the ordo class is specifically for rare diseases, but we broaden to be inclusive of HH1 inborn errors of metabolism A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma. https://www.malacards.org/card/endocrine_gland_cancer Endocrine tumour endocrine neoplasm DOID:170 ICD9:194.9 MEDGEN:56319 MESH:D004701 NCIT:C3575 UMLS:C0153658 cancer of endocrine gland endocrine cancer endocrine gland cancer endocrine neoplasm, malignant malignant endocrine gland neoplasm malignant endocrine gland tumor malignant endocrine gland tumour malignant endocrine neoplasm malignant endocrine tumor malignant endocrine tumour malignant neoplasm of endocrine gland malignant neoplasm of the endocrine gland malignant tumor of endocrine gland malignant tumor of the endocrine gland malignant tumour of the endocrine gland MONDO:0021069 malignant endocrine neoplasm A neoplasm (disease) that involves the digestive system. EFO:0008549 MEDGEN:8398 MESH:D005770 NCIT:C3052 UMLS:C0012243 GI neoplasm GI system neoplasm GI system tumor GI system tumour GI tumor GI tumour digestive neoplasm digestive system neoplasm (disease) digestive system tumor digestive system tumour digestive tumor digestive tumour gastrointestinal neoplasm gastrointestinal system neoplasm gastrointestinal system tumor gastrointestinal system tumour gastrointestinal tumor gastrointestinal tumour neoplasm of GI system neoplasm of digestive system neoplasm of gastrointestinal system neoplasm of the GI system neoplasm of the digestive system neoplasm of the gastrointestinal system tumor of GI system tumor of digestive system tumor of gastrointestinal system tumor of the GI system tumor of the digestive system tumor of the gastrointestinal system tumour of GI system tumour of digestive system tumour of gastrointestinal system tumour of the GI system tumour of the digestive system tumour of the gastrointestinal system MONDO:0021223 digestive system neoplasm A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma. https://github.com/monarch-initiative/mondo/issues/5166 https://www.malacards.org/card/liver_benign_neoplasm DOID:916 MEDGEN:232599 NCIT:C7103 NCIT:C7106 ONCOTREE:LIVER SCTID:126851005 UMLS:C1333976 epithelial hepatic and intrahepatic bile duct neoplasm hepatic and intrahepatic bile duct neoplasm liver and intrahepatic bile duct epithelial neoplasm liver and intrahepatic bile duct neoplasm liver neoplasm liver neoplasm (disease) liver tumor liver tumour neoplasm of liver tumor of liver tumour of liver MONDO:0024477 liver and intrahepatic bile duct neoplasm A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction). EFO:1001375 ICD10CM:I20-I25 MEDGEN:101801 MESH:D017202 NANDO:2100070 NCIT:C50625 SCTID:414545008 UMLS:C0151744 icd11.foundation:1964269418 IHD ischaemic disease of myocardium ischaemic heart disease ischemic disease of myocardium ischemic heart disease myocardium ischaemic disease myocardium ischemic disease disease, ischaemic heart disease, ischemic heart diseases, ischaemic heart diseases, ischemic heart heart disease, ischaemic heart disease, ischemic heart diseases, ischaemic heart diseases, ischemic ischaemic heart diseases ischemia, myocardial ischemias, myocardial ischemic heart diseases myocardial Ischemias MONDO:0024644 myocardial ischemia An instance of skin disease that is caused by a modification of the individual's genome. https://github.com/monarch-initiative/mondo/issues/5682 MESH:D012873 SCTID:239001006 disease, genetic skin diseases, genetic skin genetic skin disease genetic skin diseases genodermatosis skin disease, genetic MONDO:0100118 hereditary skin disorder https://github.com/monarch-initiative/mondo/issues/5858 human disease or disorder MONDO:0700096 human disease A grouping class for human diseases classified by the body system or anatomical component primarily affected. MONDO:7770006 This term is intended solely for classification purposes and should not be used for direct data annotation. disease by body system or component A grouping class for human diseases classified by the molecular, biochemical, cellular, anatomic, developmental or physiological process that is disrupted. MONDO:7770007 This term is intended solely for classification purposes and should not be used for direct data annotation. disease by developmental or physiological process A grouping class for human diseases classified by their etiologic mechanism, encompassing primarily intrinsic (genetic, genomic), primarily extrinsic (e.g., infections, toxins, radiation), and complex multifactorial (e.g. nutritional) causes. MONDO:7770008 This term is intended solely for classification purposes and should not be used for direct data annotation. disease by etiologic mechanism Viruses GC_ID:1 ncbi_taxonomy Vira Viridae viruses Viruses Teleostomi Euteleostomi bony vertebrates bony vertebrates Euteleostomi Dipnotetrapodomorpha Boreotheria Boreoeutheria Bacteria eubacteria GC_ID:11 PMID:10425795 PMID:10425796 PMID:10425797 PMID:10490293 PMID:10843050 PMID:10939651 PMID:10939673 PMID:10939677 PMID:11211268 PMID:11321083 PMID:11321113 PMID:11411719 PMID:11540071 PMID:11542017 PMID:11542087 PMID:11760965 PMID:12054223 PMID:2112744 PMID:270744 PMID:7520741 PMID:8123559 PMID:8186100 PMID:8590690 PMID:9103655 PMID:9336922 eubacteria ncbi_taxonomy Monera Procaryotae Prokaryota Prokaryotae bacteria not Bacteria Haeckel 1894 prokaryote prokaryotes Bacteria Homo/Pan/Gorilla group Homininae Archaea GC_ID:11 PMID:10425795 PMID:10425796 PMID:10425797 PMID:10490293 PMID:10843050 PMID:10939651 PMID:10939673 PMID:10939677 PMID:11211268 PMID:11321083 PMID:11321113 PMID:11411719 PMID:11540071 PMID:11541975 PMID:11542064 PMID:11542149 PMID:11760965 PMID:12054223 PMID:2112744 PMID:25527841 PMID:270744 PMID:8123559 PMID:8590690 PMID:9103655 PMID:9336922 ncbi_taxonomy Archaebacteria Mendosicutes Metabacteria Monera Procaryotae Prokaryota Prokaryotae archaea prokaryote prokaryotes Archaea Eukaryota eucaryotes eukaryotes GC_ID:1 PMID:23020233 PMID:30257078 eucaryotes eukaryotes ncbi_taxonomy Eucarya Eucaryotae Eukarya Eukaryotae eukaryotes NCBITaxon:2759 Eukaryota Euarchontoglires Euarchontoglires Anthropoidea Simiiformes ape apes Hominoidea Tetrapoda tetrapods tetrapods Tetrapoda Amniota amniotes amniotes Amniota Theria Theria <Mammalia> Opisthokonta GC_ID:1 ncbi_taxonomy Fungi/Metazoa group opisthokonts NCBITaxon:33154 Opisthokonta metazoans multicellular animals Animalia animals Metazoa Bilateria Bilateria deuterostomes Deuterostomia A misfolded protein that has the ability to transmit its misfolded shape onto normal variants of the same protein. https://en.wikipedia.org/wiki/Prion GC_ID:1 ncbi_taxonomy prion Haplorrhini Mammalia mammals mammals mammals Mammalia Eumetazoa chordates chordates Chordata Vertebrata <vertebrates> Vertebrata vertebrates Vertebrata vertebrates vertebrates Vertebrata <Metazoa> Vertebrata <vertebrates> Gnathostomata jawed vertebrates Gnathostomata <vertebrate> Sarcopterygii Craniata Craniata <chordata> eutherian mammals placental mammals placentals Placentalia placentals Eutheria primate Primata primates Primates Catarrhini great apes Pongidae Hominidae humans Homo Homo sapiens Homo sapiens human human being man person GC_ID:1 human man ncbi_taxonomy humans Homo sapiens Homo sapiens An individual's total number of brothers and sisters. C102469 Qualitative Concept Number of Siblings C0557094 FDA Number of Siblings Number of Siblings The age of the subject at the time of the vaccination. C103173 Organism Attribute Age at Time of Vaccination C3641107 FDA Age at Time of Vaccination Age at Vaccination Age at the Time of Vaccination Age at Time of Vaccination A group of people characterized by the practice of a common religion. C103282 Population Group Religious Group C0597369 Religious Group Religious Group A member of the Jewish faith whose ancestors lived in North Africa, the Middle East, Portugal or Spain. C103283 Population Group Sephardic Jew C0574825 CDISC A person of Sephardic Jewish descent. SEPHARDIC JEW Sephardi Sephardic Jew Sephardic Jew Individuals who do not necessarily identify with any particular race or others who do not wish to self select into a racial category(ies). C104495 Population Group Other Race C0425379 OORO SeroNet OTHER RACE Other Race RACEOTH Other Race The age at which permanent cessation of menses occurs. C106497 Clinical Attribute Age at Menopause C1629609 CDISC The age at which permanent cessation of menses occurred. (NCI) Age at Menopause MENOAGE Menopause Age Age at Menopause A person having origins in the original peoples of Asia, but not China, India, Korea, the Philippine Islands or Vietnam. C107601 Population Group Other Asian C0438971 FDA Other Asian Other Asian A person having origins in the original peoples of the Pacific Islands, but not Guam, Hawaii, the Mariana Islands or Samoa. C107602 Population Group Other Pacific Islander C1553351 CDISC FDA A person having origins in the original peoples of the Pacific Islands, but not Guam, Hawaii, the Mariana Islands or Samoa. (NCI) OTHER PACIFIC ISLANDER Other Pacific Islander Other Pacific Islander A person of Mexican or Mexican American culture or origin, regardless of race. C107607 Population Group Mexican or Mexican American C3829110 FDA Mexican or Mexican American Mexican or Mexican American A person of Cuban culture or origin, regardless of race. C107608 Population Group Cuban C1553379 CDISC FDA A person of Cuban descent. CUBAN Cuban Cuban A person of Spanish culture or origin, but not Cuban, Mexican, Puerto Rican, South or Central American, regardless of race. C107609 Population Group Other Hispanic or Latino(a) C3828691 FDA Other Hispanic or Latino(a) Other Hispanic or Latino(a) The time elapsed between the day of conception and the day of delivery. C114088 Organism Attribute Conception Age C3827345 NICHD The time elapsed between the day of conception and the day of delivery. Conception Age Conceptional Age Conceptual Age Post-Conceptional Age Post-Conceptual Age Conception Age Chronological age reduced by the number of weeks born before 40 weeks of gestation; most appropriately used to describe children up to 3 years of age who were born preterm. C114089 Organism Attribute Corrected Age C3831006 INC NICHD Chronological age reduced by the number of weeks born before 40 weeks of gestation. Chronological age reduced by the number of weeks born before 40 weeks of gestation; most appropriately used to describe children up to 3 years of age who were born preterm. Adjusted Age Corrected Age Corrected Gestational Age Corrected Age Best estimate of the first day of last menstrual period to birth plus time elapsed from day of birth. C114090 Organism Attribute Postmenstrual Age C3828508 INC NICHD Best estimate of the first day of last menstrual period to birth plus time elapsed from day of birth. Postmenstrual Age Postmenstrual Age Birth weight less than 1500 grams. C114935 Finding Very Low Birth Weight C0282666 GAIA NICHD Birth weight less than 1500 grams. VLBW Very Low Birth Weight Very Low Birth Weight Birth weight less than 1000 grams. C114936 Finding Extremely Low Birth Weight C0456065 GAIA NICHD Birth weight less than 1000 grams. ELBW Extremely Low Birth Weight Extremely Low Birth Weight Birth weight less than 750 grams. C114937 Finding Ultra Low Birth Weight C3896584 ULBW Ultra Low Birth Weight Ultra Low Birth Weight The earning of income directly from customers, clients, or other organizations rather than as a specified salary or wages from an employer. C116000 Functional Concept Self-Employed C0425092 Self-Employed Self-Employment Self-employed Self-Employed An employment agreement where the employer pays an arranged amount at a steady yearly interval regardless of hours worked. C116001 Functional Concept Salaried Annual Employment C3897659 Salaried Annual Employment Salaried Annual Worker Salaried annual Salaried Annual Employment An employment arrangement where a worker is compensated a wage based on the number of hours worked. C116002 Functional Concept Hourly Employment C0681101 Hourly Employment Hourly Wage Employment Wages hourly Hourly Employment A person's optimum weight as calculated by a standard methodology. C117976 Quantitative Concept Ideal Body Weight C0421272 CDISC A person's optimum weight as calculated by a standard methodology. IDEALWT Ideal Body Weight Ideal Body Weight Height greater than two standard deviations below the mean of the appropriate reference population for the age and sex of the individual. C118686 Finding Short Stature C3280176 NICHD Height greater than two standard deviations below the mean of the appropriate reference population for the age and sex of the individual. Short Stature Short Stature Idiopathic short stature in a child when either one or both parents is short in stature. C118688 Finding Familial Idiopathic Short Stature C3899157 NICHD Idiopathic short stature in a child when either one or both parents is short in stature. Constitutional Short Stature Familial Idiopathic Short Stature Familial Idiopathic Short Stature Height greater than two standard deviations below the mean for the age and sex of the reference population. C118689 Finding Idiopathic Short Stature C1740819 NICHD Height less than two standard deviations below the mean for the age and sex of the reference population for the age and sex of the individual for which no underlying cause can be identified. ISS Idiopathic Short Stature Idiopathic Short Stature Idiopathic short stature in a child when neither parent is short in stature. C118690 Finding Non-familial Idiopathic Short Stature C3898124 NICHD Idiopathic short stature in a child when neither parent is short in stature. Non-Familial Idiopathic Short Stature Non-familial Idiopathic Short Stature Non-familial Idiopathic Short Stature Height greater than two standard deviations above the mean of the appropriate reference population for the age and sex of the individual. C118691 Finding Tall Stature C3279055 NICHD Height greater than two standard deviations above the mean of the appropriate reference population for the age and sex of the individual. Tall Stature Tall Stature Tall stature for which no underlying cause can be found. C118692 Finding Idiopathic Tall Stature C3898813 NICHD Height more than two standard deviations above the mean of the appropriate reference population for the age and sex of the individual for which no underlying cause can be identified. Idiopathic Tall Stature Idiopathic Tall Stature Idiopathic tall stature in a child when either one or both parents is tall in stature. C118693 Finding Familial Idiopathic Tall Stature C3899156 NICHD Idiopathic tall stature in a child when either one or both parents is tall in stature. Constitutional Tall Stature Familial Idiopathic Tall Stature Familial Tall Stature Familial Idiopathic Tall Stature Idiopathic tall stature in a child when neither parent is tall in stature. C118695 Finding Non-familial Idiopathic Tall Stature C3897108 NICHD Idiopathic tall stature in a child when neither parent is tall in stature. Non-Familial Idiopathic Tall Stature Non-familial Idiopathic Tall Stature Non-familial Idiopathic Tall Stature The money received by retired workers who have paid in to the Social Security system during their working years. C120451 Group Attribute Social Security Retirement Benefit C0037435 Social Security Social Security Retirement Benefit Social Security Retirement Benefit A fixed sum paid regularly to a person by their former employer. C120452 Group Attribute Pension C0030854 Pension Pension The pressure within the left ventricle following the completion of diastolic filling, just prior to systole. C120919 Quantitative Concept Left Ventricular End Diastolic Pressure C0456190 ACC/AHA CDISC The pressure within the left ventricle of the heart at the end of the period when the chambers of the heart refill with blood and just before the contraction begins. LVEDP Left Ventricular End Diastolic Pressure Left ventricular end-diastolic pressure (mm Hg) Left Ventricular End Diastolic Pressure The pressure in the left ventricle at any point prior to the ejection of its contents into the aorta (systole). C120920 Quantitative Concept Left Ventricular Systolic Pressure C0456189 CDISC The pressure within the left ventricle of the heart during the contraction of the left ventricle of the heart. LVSYSBP Left Ventricular Systolic Pressure Left Ventricular Systolic Pressure An approximate calculation of the gestational age of the fetus. C122188 Organism Attribute Estimated Gestational Age C0262472 CDISC An approximate calculation of the gestational age of the fetus, neonate, or infant. EGESTAGE Estimated Gestational Age Estimated Gestational Age The number of education years that a subject has competed. C122393 Qualitative Concept Number of Years of Education C4054327 CDISC The number of years of education that a person has completed. EDUYRNUM Number of Years of Education Number of Years of Education The age at which the first episode occurred. C124438 Organism Attribute Age at First Episode C4085940 CDISC The age at which the first episode occurred. AGEEPSD1 Age At First Episode Age at First Episode Age at First Episode The age at which the first hospitalization event occurred. C124439 Organism Attribute Age at First Hospitalization C4085941 CDISC The age at which the first hospitalization event occurred. AGEHOSP1 Age At First Hospitalization Age at First Hospitalization Age at First Hospitalization The age at which the first treatment event occurred. C124440 Organism Attribute Age at First Treatment C4085942 CDISC The age at which the first treatment for the condition occurred. AGETRT1 Age At First Treatment Age at First Treatment Age at First Treatment The maternal body weight adjusted for the weight of the gravid uterus. This is derived by subtracting the gravid uterus weight from the total maternal body weight. C124477 Conceptual Entity Gravid Uterus Adjusted Maternal Body Weight C4086368 CDISC The maternal body weight adjusted for the weight of the gravid uterus. This is derived by subtracting the gravid uterus weight from the total maternal body weight. BWADJGU Gravid Uterus Adjusted Body Weight Gravid Uterus Adjusted Maternal Body Weight Gravid Uterus Adjusted Maternal Body Weight An estimate or direct measurement of the heaviness of a fetus. C124479 Conceptual Entity Fetal Body Weight C0751992 CDISC The weight of a fetus. BWFETAL Fetal Body Weight Fetal Body Weight A measurement of the average weight of all live fetuses. C124627 Conceptual Entity Average Live Fetal Weight C4086012 CDISC A measurement of the average weight of all live fetuses. Average Live Fetal Weight FWAVGL Average Live Fetal Weight A measurement of the average weight of all live female fetuses. C124628 Conceptual Entity Average Female Live Fetal Weight C4086011 CDISC A measurement of the average weight of all live female fetuses. Average Female Live Fetal Weight FWAVGLF Average Female Live Fetal Weight A measurement of the average weight of all live male fetuses. C124629 Conceptual Entity Average Male Live Fetal Weight C4086996 CDISC A measurement of the average weight of all live male fetuses. Average Male Live Fetal Weight FWAVGLM Average Male Live Fetal Weight A measurement of the total weight of all live fetuses. C124630 Conceptual Entity Total Live Fetal Weight C4086909 CDISC A measurement of the total weight of all live fetuses. FWTOTL Total Live Fetal Weight Total Live Fetal Weight The age at which a minor assumes legal control over their person, actions, and decisions. C126362 Organism Attribute Age of Majority CL504920 Age of Majority Age of Majority Denotes a person whose ancestry is in any of the countries of the central part of the African continent: Burundi, the Central African Republic, Chad, the Democratic Republic of the Congo, and Rwanda. C126528 Population Group Central African C0238602 Central African Central African Denotes a person whose ancestry is in any of the countries of the northern part of the African continent: Algeria, Egypt, Libya, Morocco, Sudan, Tunisia, and Western Sahara. C126529 Population Group North African C0238604 North African North African Denotes a person whose ancestry is in the country of South Africa. C126530 Population Group South African C0238605 South African South African Denotes a person whose ancestry is in any of the countries of the Americas or the Caribbean where Spanish or Portuguese is spoken. C126531 Population Group Latin American C1553378 CDISC A person of Latin American descent. LATIN AMERICAN Latin American Latin American Denotes a person whose ancestry is in any of the countries of South America. C126532 Population Group South American C0425359 CDISC A person of South American descent. SOUTH AMERICAN South American South American Denotes a person whose ancestry is in any of the Asian countries south of China, east of India, west of New Guinea and north of Australia. C126533 Population Group Southeast Asian C0238697 CDISC A person having origins in any of the original peoples of Southeast Asia. SOUTHEAST ASIAN Southeast Asian Southeast Asian Denotes a person whose ancestry is in any of the Asian countries between the Caspian Sea in the west, China in the east, Afghanistan in the south, and Russia in the north. C126534 Population Group Central Asian C0238696 CDISC A person having origins in any of the original peoples of Central Asia. CENTRAL ASIAN Central Asian Central Asian Denotes a person whose ancestry is in the country or continent of Australia. C126535 Population Group Australian C0238711 Australian Australian Denotes a person whose ancestry is in the country of New Zealand. C126536 Population Group New Zealander CL505027 New Zealander New Zealander Denotes a person whose ancestry is in the country of Iceland. C126537 Population Group Icelander C0337808 Icelander Icelandic Icelander Denotes a person whose ancestry is in the countries of Scandinavia: Denmark, Norway and Sweden. Finland and Iceland are generally included as part of the Scandinavian region. C126538 Population Group Scandinavian C0240951 Scandinavian Scandinavian A collection of ethnic geographical categories including African American, North American, Latin American, Caribbean, and South American. C128457 Population Group American Ethnicity C0596070 American American Ethnicity Americas American Ethnicity A collection of ethnic geographical categories including Australian and New Zealander. C128458 Population Group Australian/New Zealand Ethnicity CL509688 Australian/New Zealand Australian/New Zealand Ethnicity Australian/New Zealand Ethnicity A collection of ethnic geographical categories including Middle Eastern and Hispanic. C128459 Population Group Intercontinental Ethnicity CL509475 Intercontinental Intercontinental Ethnicity Intercontinental Ethnicity Denotes a person of African ancestral origins whose family settled in America. C128937 Population Group African American CL415133 CDISC A person having origins in the original peoples of sub-Saharan Africa and the United States. AFRICAN AMERICAN African American Afro American Afro-American African American A person having origins in the original peoples of sub-Saharan Africa or the Caribbean. C128938 Population Group Black C0005680 CDISC A person having origins in the original peoples of sub-Saharan Africa or the Caribbean. BLACK Black Black Populations Black Denotes a person of African ancestral origins whose family settled in Central America. C128991 Population Group Black Central American CL512097 CDISC A person having origins in the original peoples of sub-Saharan Africa and Central America. BLACK CENTRAL AMERICAN Black Central American Black Central American Denotes a person of African ancestral origins whose family settled in South America. C128992 Population Group Black South American CL512098 CDISC A person having origins in the original peoples of sub-Saharan Africa and South America. BLACK SOUTH AMERICAN Black South American Black South American A person having origins in the any of the countries of Central America who identifies as white. C128993 Population Group White Central American CL512246 CDISC A person having origins in the original peoples of Europe, the Middle East, or North Africa, and Central America. WHITE CENTRAL AMERICAN White Central American White Central American A person having origins in the any of the countries of South America who identifies as white. C128994 Population Group White South American CL512247 CDISC A person having origins in the original peoples of Europe, the Middle East, or North Africa, and South America. WHITE SOUTH AMERICAN White South American White South American The maximum pressure exerted into the systemic arterial circulation during the contraction of the right ventricle of the heart. C129953 Quantitative Concept Right Ventricular Systolic Pressure C0456181 RVSP Right Ventricular Systolic Pressure Right Ventricular Systolic Pressure Blood pressure in the pulmonary artery. C129958 Clinical Attribute Pulmonary Artery Pressure C0428642 PAP Pulmonary Artery Pressure Pulmonary Artery Pressure Blood pressure within the left atrium. It is commonly measured indirectly by a pulmonary capillary wedge pressure. C129959 Clinical Attribute Left Atrial Pressure C0456170 LAP Left Atrial Pressure PLA Left Atrial Pressure The estimated arithmetic average of atrial pressure. C130056 Quantitative Concept Estimated Mean Atrial Pressure CL514049 Estimated Mean Atrial Pressure Estimated Mean Atrial Pressure An approximate determination of the weight of a body. C132482 Conceptual Entity Estimated Body Weight CL521346 CDISC An approximate determination of the body weight of the subject. EWEIGHT Estimated Body Weight Estimated Weight Estimated Body Weight The age at which death occurred. C135383 Organism Attribute Age at Death C1546180 CDISC OORO Patient age at death. This is calculated to at least 4 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the day. Calculation to 7 decimal places would enable resolving to the second. Age is not a PHI restricted element for patients younger than 89. The age at which death occurred. (NCI) AGEDTH Age At Date of Death Age at Death Age at Death The result of a body mass index measurement. C138901 Finding Body Mass Index Finding C0578022 BMI Body Mass Index Body Mass Index Finding Body Mass Index Finding Indicates a body mass index measurement less than 19. C138932 Finding Body Mass Index Less Than 19 CL526388 BMI < 19 Body Mass Index Less Than 19 Body Mass Index Less Than 19 Indicates a body mass index measurement greater than or equal to 19 but below 21. C138933 Finding Body Mass Index 19 to Less Than 21 CL526479 BMI 19 to < 21 Body Mass Index 19 to Less Than 21 Body Mass Index 19 to Less Than 21 Indicates a body mass index measurement greater than or equal to 21 but below 23. C138934 Finding Body Mass Index 21 to Less Than 23 CL526478 BMI 21 to < 23 Body Mass Index 21 to Less Than 23 Body Mass Index 21 to Less Than 23 Indicates a body mass index measurement greater than or equal to 23. C138935 Finding Body Mass Index Greater Than or Equal to 23 CL526477 BMI > 23 Body Mass Index Greater Than or Equal to 23 Body Mass Index Greater Than or Equal to 23 An indication that an individual's age is or was greater than 85 years. C138936 Organism Attribute Age Greater than 85 Years CL526476 Age > 85 Age Greater than 85 Years Age Over 85 Years Age Greater than 85 Years An indication that an individual's age is or was between 80 and 85 years. C138937 Organism Attribute Age Between 80 and 85 Years CL526482 Age 80-85 Age Between 80 and 85 Years Age Between 80 and 85 Years An indication that an individual's age is or less than 80 years. C138938 Organism Attribute Age Less than 80 Years CL526971 Age < 80 Age Less than 80 Years Age Less than 80 Years A quantitative estimate of the pressure in a given cardiovascular structure during ventricular systole. C139031 Quantitative Concept Estimated Systolic Blood Pressure CL526532 CDISC A quantitative estimate of the pressure in a given cardiovascular structure during ventricular systole. Estimated Systolic Blood Pressure SYSPRS_E Systolic Pressure, Estimated Estimated Systolic Blood Pressure The age at which the full-time use of an entity occurred. C139175 Organism Attribute Age at Full-Time Use CL526611 CDISC The age at which the full-time use of a pre-specified object first occurred. AGEFTUSE Age at Full-Time Use Age at Full-Time Use The determination of the liver pathology through the assessment of multiple blood test parameters, taking into account the age and sex of the patient. C147385 Laboratory Procedure Liver Fibrosis Score C4034373 CDISC A scoring system that evaluates liver pathology through the assessment of multiple blood test parameters, taking into account additional demographic factors such as the age and/or sex of the subject. LVFBRSC Liver Fibrosis Score Liver Fibrosis Score A leave of absence granted because of illness. C148251 Functional Concept Sick Leave C0242807 On sick leave from full- or part-time work Sick Leave Sick Leave A leave of absence granted because of physical or mental disability. C148252 Functional Concept Disability Leave C0242805 Disability Leave On disability leave from full- or part-time work Disability Leave Denotes a person whose ancestry is in any of the Asian countries bordering the Pacific Ocean: China, Japan, Mongolia, North Korea, and South Korea. C153342 Population Group Northeastern Asian CL554446 Northeastern Asian Northeastern Asian Ancestry Northeastern Asian Descent Northeastern Asian Denotes a person whose ancestry is in any of the Asian countries bordering Africa, such as Afghanistan, Armenia, Azerbaijan, Bahrain, Cyprus, Gaza Strip, Georgia, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Qatar, Saudi Arabia, Syrian Arab Republic, Turkey, United Arab Emirates, West Bank, and Yemen. C153343 Population Group Western Asian C0238699 CDISC A person having origins in any of the original peoples of Western Asia. WEST ASIAN Western Asian Western Asian Ancestry Western Asian Descent Western Asian Denotes a person whose ancestry is in any of the European countries of the Balkan peninsula: Turkey, Albania, Bosnia and Herzegovina, Bulgaria, Republic of Macedonia, Romania, Serbia, Greece, Croatia, Moldova and Montenegro. C153344 Population Group Southeastern European CL554447 Southeastern European Southeastern European Ancestry Southeastern European Descent Southeastern European Denotes a person whose ancestral origins are in any of the African countries that are fully or partially located south of the Sahara desert. C153346 Population Group Sub-Saharan African CL554448 CDISC A person having origins in any of the original peoples of sub-Saharan Africa. SUB-SAHARAN AFRICAN Sub-Saharan African Sub-Saharan African Ancestry Sub-Saharan African Descent Sub-Saharan African Indicates a body mass index measurement greater than 25. C153368 Finding Body Mass Index Greater Than 25 Body Mass Index Greater Than 25 CL554524 CTRP BMI Greater than 25 Body Mass Index Greater Than 25 Body Mass Index Greater Than 25 A smoker who smokes more than 10 cigarettes per day, or an equivalent quantity of cigar or pipe smoke. C154510 Organism Attribute Heavy Smoker C0857118 ACC/AHA Heavy Smoker Heavy Tobacco Smoker Heavy tobacco smoker Heavy Smoker A smoker who smokes less than 10 cigarettes per day, or an equivalent quantity of cigar or pipe smoke. C154511 Organism Attribute Light Smoker C3494624 ACC/AHA Light Smoker Light Tobacco Smoker Light tobacco smoker Light Smoker A name used for the non-Bantu indigenous peoples of Southern Africa. C154874 Population Group Khoisan CL555684 CDISC The native people of the Western Cape in southern Africa. KHOISAN Khoisan Khoisan The native people of Australia. C154875 Population Group Aboriginal Australian C0337948 CDISC The native people of Australia. ABORIGINAL AUSTRALIAN Aboriginal Australian Aboriginal Australian A measurement of the distance between the pubic symphysis and the top of the palpable uterus. C154876 Quantitative Concept Fundal Height C0426012 CDISC A measurement of the distance between the pubic symphysis and the top of the palpable uterus. FUNDHT Fundal Height Fundal Height An indication of the position on a scale measuring compensation or monetary support. C154890 Group Attribute Income Level CL555700 CDISC An indication of the position on a scale measuring revenue or monetary support. INCMLVL Income Level Income Level The age of an individual at the time of initial pathologic diagnosis. C156420 Organism Attribute Age at Diagnosis C1828181 DIPG/DMG NAACCR PCDC AGE_AT_TUMOR_ASSESSMENT Age at Diagnosis Age at diagnosis Age at Diagnosis A person of mixed race, whose ancestry is from one or more of the naturalized racial groups of Southern Africa (typically Western European, South Asian, or Southeastern Asian) and one or more of the indigenous Southern African peoples. C156583 Population Group Southern African Coloured CL935747 CDISC A person whose ancestry is from one or more of the indigenous Southern African peoples and one or more of the naturalized racial groups of Southern Africa (typically Western European, South Asian, or Southeastern Asian). SOUTHERN AFRICAN COLOURED Southern African Coloured Southern African Coloured An individual who stopped smoking more than 15 years prior. C156828 Intellectual Product Current Reformed Smoker, More than 15 Years CL935830 CPTAC GDC Current Reformed Smoker for > 15 yrs Current Reformed Smoker for > 15 yrs Current Reformed Smoker, More than 15 Years Current reformed smoker, more than 15 years Current Reformed Smoker, More than 15 Years An individual who stopped smoking within the past 15 years. C156829 Intellectual Product Current Reformed Smoker Within Past 15 Years CL935827 CPTAC GDC Current Reformed Smoker for < or = 15 yrs Current Reformed Smoker Within Past 15 Years Current Reformed Smoker for < or = 15 yrs Current reformed smoker within past 15 years Current Reformed Smoker Within Past 15 Years An individual who stopped smoking an unknown number of years prior. C156830 Intellectual Product Current Reformed Smoker, Years Unknown CL935828 CPTAC GDC Current Reformed Smoker, Duration Not Specified Current Reformed Smoker, Duration Not Specified Current Reformed Smoker, Years Unknown Current reformed smoker, years unknown Current Reformed Smoker, Years Unknown A type of insurance designed to cover some of or all the cost of treating an insured person's illnesses or injuries. In some cases, it pays for preventive care, such as annual physicals and diagnostic tests. C157356 Intellectual Product Health Insurance C0021682 OORO Insurance coverage categories currently available to patient. This is important for research and health care policy using social determinants of health (SDOH). Health Benefit Plan Health Insurance Health Insurance Coverage Insurance Health Insurance A system of health insurance benefits designed to cover a national population against the costs of health care. It may be administered by the public sector, the private sector, or a combination of both. C157357 Intellectual Product National Health Insurance C0027452 NHI National Health Insurance SHI Statutory Health Insurance National Health Insurance Various private health insurance plans designed to supplement the coverage of Medicare to help pay out-of-pocket costs. C157358 Intellectual Product Medigap C0085558 Medigap Medigap Insurance Medigap A state-run insurance program that provides low-cost health coverage to children in families that earn too much money to qualify for Medicaid but not enough to buy private insurance. C157359 Intellectual Product Children's Health Insurance Program C4042889 CHIP Children's Health Insurance Program Childrens Health Insurance Program Children's Health Insurance Program Health insurance programs that are run and funded at the state level. C157360 Intellectual Product State-sponsored Health Plan CL936955 State-sponsored Health Insurance State-sponsored Health Plan State-sponsored Health Plan A federal health care program for uniformed service members, retirees, and their families around the world. The government administers Tricare by contracting with private entities C157361 Intellectual Product Tricare CL936951 OORO CHAMPUS Civilian Health and Medical Program of the Uniformed Services Private Insurance TRICARE Tricare Tricare A comprehensive health care program, administered by the Department of Veterans Affairs, designed to provide health care services for military veterans. C157362 Intellectual Product Civilian Health and Medical Program of the Department of Veterans Affairs CL936952 CHAMPVA Civilian Health and Medical Program of the Department of Veterans Affairs Civilian Health and Medical Program of the Department of Veterans Affairs A Chinese person from the Han ethnic group (including Chuanqing). C158158 Population Group Han Chinese C0814942 CDISC A Chinese person from the Han ethnic group (including Chuanqing). HA HAN Han Chinese Han Chinese A Chinese person from the Zhuang ethnic group. C158159 Population Group Zhuang Chinese CL937649 CDISC A Chinese person from the Zhuang ethnic group. ZH ZHUANG Zhuang Chinese Zhuang Chinese A Chinese person from the Hui (including Utsuls of Hainan, descended from Cham refugees) ethnic group. C158160 Population Group Hui Chinese CL937648 CDISC A Chinese person from the Hui (including Utsuls of Hainan, descended from Cham refugees) ethnic group. HU HUI Hui Chinese Hui Chinese A Chinese person from the Man ethnic group. C158161 Population Group Man Chinese CL938140 CDISC A Chinese person from the Man ethnic group. MA MAN Man Chinese Man Chinese A Chinese person from the Uygur ethnic group. C158162 Population Group Uygur Chinese CL937646 CDISC A Chinese person from the Uygur ethnic group. UG UYGUR Uighur Chinese Uygur Chinese Uygur Chinese A Chinese person from the Miao (Including Hmong) ethnic group. C158163 Population Group Miao Chinese CL937647 CDISC A Chinese person from the Miao (Including Hmong) ethnic group. MH MIAO Miao Chinese Miao Chinese A Chinese person from the Yi ethnic group. C158164 Population Group Yi Chinese CL937679 CDISC A Chinese person from the Yi ethnic group. YI Yi Chinese Yi Chinese A Chinese person from the Tujia ethnic group. C158165 Population Group Tujia Chinese CL937680 CDISC A Chinese person from the Tujia ethnic group. TJ TUJIA Tujia Chinese Tujia Chinese A Chinese person from the Zang (including Amdowa, Khampa and some Pumi speakers) ethnic group. C158166 Population Group Zang Chinese CL937678 CDISC A Chinese person from the Zang (including Amdowa, Khampa and some Pumi speakers) ethnic group. ZA ZANG Zang Chinese Zang Chinese A Chinese person from the Mongol ethnic group. C158167 Population Group Mongol Chinese C0337892 CDISC A Chinese person from the Mongol ethnic group. MG MONGOL Mongol Chinese Mongol Chinese A Chinese person from the Dong ethnic group. C158168 Population Group Dong Chinese CL938117 CDISC A Chinese person from the Dong ethnic group. DO DONG Dong Chinese Dong Chinese A Chinese person from the Buyei ethnic group. C158169 Population Group Buyei Chinese CL938158 CDISC A Chinese person from the Buyei ethnic group. BUYEI BY Buyei Chinese Buyei Chinese A Chinese person from the Yao ethnic group. C158170 Population Group Yao Chinese CL938097 CDISC A Chinese person from the Yao ethnic group. YA YAO Yao Chinese Yao Chinese A Chinese person from the Bai ethnic group. C158171 Population Group Bai Chinese CL938128 CDISC A Chinese person from the Bai ethnic group. BA BAI Bai Chinese Bai Chinese A Chinese person from the Chosen ethnic group. C158172 Population Group Chosen Chinese CL938127 CDISC A Chinese person from the Chosen ethnic group. CHOSEN CS Chosen Chinese Chosen Chinese A Chinese person from the Hani (including Sangkong) ethnic group. C158173 Population Group Hani Chinese CL938100 CDISC A Chinese person from the Hani (including Sangkong) ethnic group. HANI HN Hani Chinese Hani Chinese A Chinese person from the Li ethnic group. C158174 Population Group Li Chinese CL938126 CDISC A Chinese person from the Li ethnic group. LI Li Chinese Li Chinese A Chinese person from the Kazak ethnic group. C158175 Population Group Kazak Chinese CL937677 CDISC A Chinese person from the Kazak ethnic group. KAZAK KZ Kazak Chinese Kazak Chinese A Chinese person from the Dai (including several different Tai-speaking groups historically referred to as Bai-yi) ethnic group. C158176 Population Group Dai Chinese CL938134 CDISC A Chinese person from the Dai (including several different Tai-speaking groups historically referred to as Bai-yi) ethnic group. DA DAI Dai Chinese Dai Chinese A Chinese person from the She ethnic group. C158177 Population Group She Chinese CL938137 CDISC A Chinese person from the She ethnic group. SH SHE She Chinese She Chinese A Chinese person from the Lisu ethnic group. C158178 Population Group Lisu Chinese CL938113 CDISC A Chinese person from the Lisu ethnic group. LISU LS Lisu Chinese Lisu Chinese A Chinese person from the Dongxiang ethnic group. C158179 Population Group Dongxiang Chinese CL938131 CDISC A Chinese person from the Dongxiang ethnic group. DONGXIANG DX Dongxiang Chinese Dongxiang Chinese A Chinese person from the Gelao ethnic group. C158180 Population Group Gelao Chinese CL937676 CDISC A Chinese person from the Gelao ethnic group. GELAO GL Gelao Chinese Gelao Chinese A Chinese person from the Lahu ethnic group. C158181 Population Group Lahu Chinese CL938129 CDISC A Chinese person from the Lahu ethnic group. LAHU LH Lahu Chinese Lahu Chinese A Chinese person from the Va ethnic group. C158182 Population Group Va Chinese CL938159 CDISC A Chinese person from the Va ethnic group. VA Va Chinese Va Chinese A Chinese person from the Sui ethnic group. C158183 Population Group Sui Chinese CL938093 CDISC A Chinese person from the Sui ethnic group. SU SUI Sui Chinese Sui Chinese A Chinese person from the Naxi (including Mosuo) ethnic group. C158184 Population Group Naxi Chinese CL938151 CDISC A Chinese person from the Naxi (including Mosuo) ethnic group. NAXI NX Naxi Chinese Naxi Chinese A Chinese person from the Qiang ethnic group. C158185 Population Group Qiang Chinese CL938106 CDISC A Chinese person from the Qiang ethnic group. QI QIANG Qiang Chinese Qiang Chinese A Chinese person from the Tu ethnic group. C158186 Population Group Tu Chinese CL938098 CDISC A Chinese person from the Tu ethnic group. TU Tu Chinese Tu Chinese A Chinese person from the Mulao (including the Qago) ethnic group. C158187 Population Group Mulao Chinese CL938133 CDISC A Chinese person from the Mulao (including the Qago) ethnic group. ML MULAO Mulao Chinese Mulao Chinese A Chinese person from the Xibe ethnic group. C158188 Population Group Xibe Chinese CL937675 CDISC A Chinese person from the Xibe ethnic group. XB XIBE Xibe Chinese Xibe Chinese A Chinese person from the Kirgiz ethnic group. C158189 Population Group Kirgiz Chinese C0337902 CDISC A Chinese person from the Kirgiz ethnic group. KG KIRGIZ Kirgiz Chinese Kirgiz Chinese A Chinese person from the Jingpo ethnic group. C158190 Population Group Jingpo Chinese CL938122 CDISC A Chinese person from the Jingpo ethnic group. JINGPO JP Jingpo Chinese Jingpo Chinese A Chinese person from the Daur ethnic group. C158191 Population Group Daur Chinese CL937674 CDISC A Chinese person from the Daur ethnic group. DAUR DU Daur Chinese Daur Chinese A Chinese person from the Salar ethnic group. C158192 Population Group Salar Chinese CL937673 CDISC A Chinese person from the Salar ethnic group. SALAR SL Salar Chinese Salar Chinese A Chinese person from the Blang ethnic group. C158193 Population Group Blang Chinese CL938132 CDISC A Chinese person from the Blang ethnic group. BL BLANG Blang Chinese Blang Chinese A Chinese person from the Maonan (including the Then) ethnic group. C158194 Population Group Maonan Chinese CL938116 CDISC A Chinese person from the Maonan (including the Then) ethnic group. MAONAN MN Maonan Chinese Maonan Chinese A Chinese person from the Tajik ethnic group. C158195 Population Group Tajik Chinese CL937672 CDISC A Chinese person from the Tajik ethnic group. TA TAJIK Tajik Chinese Tajik Chinese A Chinese person from the Pumi ethnic group. C158196 Population Group Pumi Chinese CL1379039 CDISC A Chinese person from the Pumi ethnic group. PM PUMI Pumi Chinese Pumi Chinese A Chinese person from the Achang ethnic group. C158197 Population Group Achang Chinese CL938111 CDISC A Chinese person from the Achang ethnic group. AC ACHANG Achang Chinese Achang Chinese A Chinese person from the Nu ethnic group. C158198 Population Group Nu Chinese CL938095 CDISC A Chinese person from the Nu ethnic group. NU Nu Chinese Nu Chinese A Chinese person from the Ewenki ethnic group. C158199 Population Group Ewenki Chinese CL937808 CDISC A Chinese person from the Ewenki ethnic group. EW EWENKI Ewenki Chinese Ewenki Chinese A Chinese person from the Gin ethnic group. C158200 Population Group Gin Chinese CL938124 CDISC A Chinese person from the Gin ethnic group. GI GIN Gin Chinese Gin Chinese A Chinese person from the Jino ethnic group. C158201 Population Group Jino Chinese CL937807 CDISC A Chinese person from the Jino ethnic group. JINO JN Jino Chinese Jino Chinese A Chinese person from the Deang ethnic group. C158202 Population Group Deang Chinese CL938119 CDISC A Chinese person from the Deang ethnic group. DE DEANG Deang Chinese Deang Chinese A Chinese person from the Bonan ethnic group. C158203 Population Group Bonan Chinese CL938094 CDISC A Chinese person from the Bonan ethnic group. BN BONAN Bonan Chinese Bonan Chinese A Chinese person from the Russ ethnic group. C158204 Population Group Russ Chinese CL938135 CDISC A Chinese person from the Russ ethnic group. RS RUSS Russ Chinese Russ Chinese A Chinese person from the Yugur ethnic group. C158205 Population Group Yugur Chinese CL937806 CDISC A Chinese person from the Yugur ethnic group. YG YUGUR Yugur Chinese Yugur Chinese A Chinese person from the Uzbek ethnic group. C158206 Population Group Uzbek Chinese CL937805 CDISC A Chinese person from the Uzbek ethnic group. UZ UZBEK Uzbek Chinese Uzbek Chinese A Chinese person from the Monba ethnic group. C158207 Population Group Monba Chinese CL938121 CDISC A Chinese person from the Monba ethnic group. MB MONBA Monba Chinese Monba Chinese A Chinese person from the Oroqen ethnic group. C158208 Population Group Oroqen Chinese CL938125 CDISC A Chinese person from the Oroqen ethnic group. OR OROQEN Oroqen Chinese Oroqen Chinese A Chinese person from the Derung ethnic group. C158209 Population Group Derung Chinese CL938123 CDISC A Chinese person from the Derung ethnic group. DERUNG DR Derung Chinese Derung Chinese A Chinese person from the Hezhen ethnic group. C158210 Population Group Hezhen Chinese CL937804 CDISC A Chinese person from the Hezhen ethnic group. HEZHEN HZ Hezhen Chinese Hezhen Chinese A Chinese person from the Gaoshan ethnic group. C158211 Population Group Gaoshan Chinese CL938120 CDISC A Chinese person from the Gaoshan ethnic group. GAOSHAN GS Gaoshan Chinese Gaoshan Chinese A Chinese person from the Lhoba ethnic group. C158212 Population Group Lhoba Chinese CL937803 CDISC A Chinese person from the Lhoba ethnic group. LB LHOBA Lhoba Chinese Lhoba Chinese A Chinese person from the Tatar ethnic group. C158213 Population Group Tatar Chinese C0337909 CDISC A Chinese person from the Tatar ethnic group. TATAR TT Tatar Chinese Tatar Chinese The native people of New Zealand. C158274 Population Group Maori C0024770 CDISC The native people of New Zealand. MAORI Maori Maori Indicates a body mass index measurement of 25 or higher. C158479 Finding Body Mass Index 25 or Greater Body Mass Index 25 or Greater CL938015 CTRP Body Mass Index 25 or Greater Body Mass Index Greater than or Equal to 25 Body Mass Index 25 or Greater The weight of an individual at the time of a procedure. C158523 Organism Attribute Weight at Time of Procedure CL937975 CPTAC Weight at Time of Procedure Weight at Time of Procedure A question about the age of the individual at the time of the initial pathologic diagnosis. C158625 Organism Attribute Age at Initial Pathologic Diagnosis CL950658 CPTAC Age at Initial Pathologic Diagnosis Age at Initial Pathologic Diagnosis Indicates that a person has attended college and receive a degree. C159746 Organism Attribute College Completion C0682187 ACC/AHA GDC Completion of education at an institution of higher education created to educate and grant degrees; often a part of a university. College Degree College College Completion College Degree College Graduate College graduate College Completion Denotes any of the indigenous people who lived in North America at the time Europeans reached the continent, including Native American, First Nations, Inuit, and Metis people. C159826 Population Group Aboriginal North American CL971209 Aboriginal Aboriginal North American Indigenous North America Indigenous People of North America Aboriginal North American Indicates a body mass index of 30 or higher. C159890 Finding Body Mass Index Greater than or Equal to 30 Body Mass Index Greater than or Equal to 30 CL968960 CTRP BMI Greater than or Equal to 30 Body Mass Index Greater than or Equal to 30 Body Mass Index Greater than or Equal to 30 A population group that is characterized by a common descriptive factor such as age, sex, race, education, etc. C161324 Population Group Demographic Group CL969972 CDISC A descriptive characterization of the study population (e.g., age, sex, race, education, etc.). Demographic Group Demographic Group A person having origins in any of the original peoples of East Asian, including China, Japan, Korea, or Mongolia. C161419 Population Group East Asian CL970098 CDISC A person having origins in any of the original peoples of East Asia. EAST ASIAN East Asian East Asian Denotes a person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, and who was either born in the United States or who was naturalized as a citizen of the United States. C16310 Population Group Asian American C0003988 CDISC A person having origins in the original peoples of Asia and the United States. Asian_American ASIAN AMERICAN Asian American Asian Americans Asian American Individuals with origins in any of the Black racial groups of Africa, including, for example, African American, Jamaican, Haitian, Nigerian, Ethiopian. and Somali. C16352 Population Group Black or African American C0085756 CDISC CTDC DIPG/DMG FDA GDC OORO PCDC SeroNet A person having origins in any of the black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American." (FDA) African_American black or african american BLACK OR AFRICAN AMERICAN BLACK_OR_AFRICAN_AMERICAN Black or African American black or african american Black or African American An individual's weight in kilograms divided by the square of the height in meters. C16358 Clinical Attribute Body Mass Index C1305855 ACC/AHA CDISC CPTAC GDC PCDC A general indicator of the body fat an individual is carrying based upon the ratio of weight to height. (NCI) A measure that relates body weight to height. BMI is sometimes used to measure total body fat and whether a person is a healthy weight. Excess body fat is linked to an increased risk of some diseases including heart disease and some cancers. A measurement that is used to indicate the body fat an individual is carrying based on the ratio of weight to height as measured in kilograms per square meters. Body_Mass_Index BMI Body Mass Index Body mass index Body mass index (BMI) [Ratio] Quetelet Index Vital Signs – BMI bmi body mass index Body Mass Index Indicates that a person's smoking status has not been recorded. C163971 Organism Attribute Smoking Status Not Documented CL979297 GDC Smoking history not documented Smoking Status Not Documented Smoking history not documented Smoking Status Not Documented An indication that a person was a smoker at the time they received a pathologic diagnosis. C164079 Organism Attribute Smoking at Diagnosis CL979291 GDC Smoker at Diagnosis Smoker at Diagnosis Smoker at Time of Diagnosis Smoking at Diagnosis Smoking at Diagnosis An individual who stopped smoking within the past 12 months. C164222 Intellectual Product Current Reformed Smoker Within 1 Year Current Reformed Smoker Within 1 Year CL977517 CTRP Current Reformed Smoker Within 1 Year Current Reformed Smoker Within 1 Year The age of a subject when entering a group, catalog, list, or study. C164338 Organism Attribute Age of Enrollment CL977620 ICDC Age of Enrollment patient age at enrollment patient_age_at_enrollment Age of Enrollment The vertical dimension of the rectangular region from which data is used in creating the reconstruction of the image. (BRIDG) C164592 Quantitative Concept Reconstruction Field of View Height CL977866 BRIDG Reconstruction Field of View Height reconstructionFieldOfViewHeight Reconstruction Field of View Height The vertical measurement or distance from the base to the top of a subject or participant. C164634 Quantitative Concept Body Height CL977857 ACC/AHA BRIDG GDC OORO PCDC A measurement that describes the vertical measurement or distance from the base, or bottom, of the patient, to the top of the patient; this can be taken as the dimension of extension of a patient who cannot stand. Patient's height in centimeters Body Height Height height subjectHeight Body Height C164835 Quantitative Concept Imaging Reconstruction Protocol Element Reconstruction Field of View Height CL977911 BRIDG The vertical dimension of the rectangular region from which data is used in creating the reconstruction of the image. EXAMPLE(S): OTHER NAME(S): Reconstruction Field of View (0018,9317) - second value NOTE(S): The units are of linear distance, e.g. mm. Imaging Reconstruction Protocol Element Reconstruction Field of View Height ImagingReconstructionProtocolElement.reconstructionFieldOfViewHeight Imaging Reconstruction Protocol Element Reconstruction Field of View Height C164947 Organism Attribute Performed Imaging Study Subject Age CL978023 BRIDG The length of time since the birth of the imaging subject in completed units. [Adapted from: Google and caDSR Public ID 2423393] EXAMPLE(S): 17 years (years completed) OTHER NAME(S): NOTE(S): This value is derived from the path: Subject > PerformedObservation > PerformedObservationResult.value (ANY=>PQ.TIME) WHERE PerformedObservation > DefinedObservation.nameCode = "age" Performed Imaging Study Subject Age PerformedImagingStudy.subjectAge Performed Imaging Study Subject Age C164948 Quantitative Concept Performed Imaging Study Subject Height CL978022 BRIDG The distance from the bottom to the top of the imaging study subject. [adapted from http://www.merriam-webster.com/dictionary/height] EXAMPLE(S): 1.75 meters OTHER NAME(S): NOTE(S): This value is derived from the path: Subject > PerformedObservation > PerformedObservationResult.value (ANY=>PQ.TIME) WHERE PerformedObservation > DefinedObservation.nameCode = "height" Performed Imaging Study Subject Height PerformedImagingStudy.subjectHeight Performed Imaging Study Subject Height C164950 Conceptual Entity Performed Imaging Study Subject Weight CL978020 BRIDG The measurement that indicates how heavy an imaging study subject is. [adapted from http://www.merriam-webster.com/dictionary/weight] EXAMPLE(S): 75 kg OTHER NAME(S): NOTE(S): This value is derived from the path: Subject > PerformedObservation > PerformedObservationResult.value (ANY=>PQ.TIME) WHERE PerformedObservation > DefinedObservation.nameCode = "weight" Performed Imaging Study Subject Weight PerformedImagingStudy.subjectWeight Performed Imaging Study Subject Weight An indication that an individual is employed in their home, either raising children full-time or keeping house. C165488 Organism Attribute Raising Children Full-time or Keeping House CL978559 Raising Children Full-time or Keeping House Raising children full-time or keeping house Raising Children Full-time or Keeping House A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease. C16564 Population Group Ethnic Group C0015031 CDISC-GLOSS CTDC GDC NICHD OORO PCDC SeroNet Denotes social groups with a shared history, sense of identity, geography, and cultural roots. Ethnicity reported by the patient. This is important for research and health care policy using social determinants of health (SDOH). Ethnic_Group ETHNICITY Ethnic Group Ethnic Origin Ethnic Origins Ethnicity Patient Reported Ethnicity ethnicity Ethnic Group A finding indicating a body mass index measurement less than or equal to 30. C165651 Finding Body Mass Index Less than or Equal to 30 Body Mass Index Less than or Equal to 30 CL978947 CTRP BMI Less than or Equal to 30 Body Mass Index Less than or Equal to 30 Body Mass Index Less than or Equal to 30 The US federal health insurance program run by the Health Care Financing Administration for people 65 years of age or older, certain people with disabilities who have not reached this age, and individuals with permanent kidney failure with dialysis or a transplant. People over 65 years old, younger disabled people, and dialysis patients are eligible for the program regardless of their income. Participating beneficiaries pay part of healthcare costs through deductible amounts. Limited monthly premiums are required from beneficiaries for non-hospital coverage. C16665 Intellectual Product Medicare C0018717 OORO A U.S. federal health insurance program for people aged 65 years or older and people with certain disabilities. Medicare pays for hospital stays, medical services, and some prescription drugs but people who receive Medicare must pay part of their healthcare costs. Medicare Medicare Medicare Program Public Health Insurance Medicare Medicare The length of a dog's life, stated in years since birth. C167281 Organism Attribute Dog Age in Years CL972265 ICDC Dog Age in Years Dog Age years Dog_Age_years Dog Age in Years A mechanism for guarding against financial aspects of risk by making payments in the form of premiums to an insurance company, which pays an agreed-upon sum to the insured in the event of loss. C16745 Intellectual Product Insurance C0021672 Insurance Insurance Insurance The age of the patient when congenital heart disease was diagnosed. C168113 Organism Attribute Age at Diagnosis of Congenital Heart Disease CL972505 ACC/AHA The age of the patient when CHD was diagnosed. Age Diagnosed Age at Diagnosis of Congenital Heart Disease Age at Diagnosis of Congenital Heart Disease Indicates that a person has attended grade school to completion. Depending on school system, this may indicate completion of sixth, seventh or eight grade. C168223 Organism Attribute Grade School Completion CL972738 ACC/AHA OORO Completed the first 6 or 8 grades of education. Elementary School Elementary School Completion Grade School Completion Grade school completion Grade School Completion Indicates that a person has completed a graduate studies program beyond a bachelor's degree. C168226 Organism Attribute Graduate Studies Completion C0013630 ACC/AHA GDC Completion of a program of study of at least the full-time equivalent of greater than or equal to 1 academic years of work beyond the bachelor’s degree. Professional or Graduate Degree Graduate Studies Completion Graduate studies Graduate Studies Completion Indicates that a person has been educated through a Individualized education plan in primary and secondary school. C168270 Organism Attribute Individualized Education Plan CL972769 ACC/AHA Individualized education plan in primary and secondary school. IEP Individualized Education Plan Individualized Education Plan The age of the patient when the symptoms of Kawasaki disease were first noted. (ACC/AHA) C168287 Organism Attribute Kawasaki Disease Symptom Onset Age CL972784 ACC/AHA The age of the patient when the symptoms of Kawasaki disease were first noted. Age When First Noted Kawasaki Disease Symptom Onset Age Kawasaki Disease Symptom Onset Age The age of the patient when the symptoms of rheumatic fever were first noted. C168423 Organism Attribute Rheumatic Fever Symptom Onset Age CL972709 ACC/AHA The age of the patient when first symptoms of rheumatic fever occurred. Age When First Symptoms Occurred Rheumatic Fever Symptom Onset Age Rheumatic Fever Symptom Onset Age Age of subject (in days) when the subject enrolled in the study. C168843 Organism Attribute Age in Days at Enrollment CL1378914 PCDC AGE_AT_ENROLLMENT Age at Enrollment Age in Days at Enrollment Age in Days at Enrollment Age of subject (in days) at the last known survival status. C168844 Organism Attribute Age in Days at Last Known Survival Status CL1378917 PCDC AGE_AT_LKSS Age at Last Known Survival Status Age in Days at Last Known Survival Status Age in Days at Last Known Survival Status Age of subject (in days) when vital signs were recorded. C168845 Organism Attribute Age in Days at Vitals CL1378916 PCDC AGE_AT_VITALS Age at Vitals Age in Days at Vitals Age in Days at Vitals Age of subject (in days) at the time of blood analysis. C168846 Organism Attribute Age in Days at Blood Analysis CL1378911 Age in Days at Blood Analysis Age in Days at Blood Analysis Age of subject (in days) at the time of lumbar puncture. C168847 Organism Attribute Age in Days at Lumbar Puncture CL1378910 Age in Days at Lumbar Puncture Age in Days at Lumbar Puncture Age of subject (in days) when molecular analysis was performed. C168848 Organism Attribute Age in Days at Molecular Analysis CL1378913 PCDC AGE_AT_MOLECULAR_ANALYSIS Age at Molecular Analysis Age in Days at Molecular Analysis Age in Days at Molecular Test Age in Days at Molecular Analysis Age of subject (in days) at the start of the adjuvant therapy. C168849 Organism Attribute Age in Days at Adjuvant Therapy Start CL1378912 Age in Days at Adjuvant Therapy Start Age in Days at Adjuvant Therapy Start Age of subject (in days) at the start of the course of treatment. C168850 Organism Attribute Age in Days at Start of Treatment Course CL1378923 PCDC AGE_AT_COURSE_START Age at Start of Treatment Course Age in Days at Start of Treatment Course Age in Days at Treatment Start Age in Days at Start of Treatment Course Age of subject (in days) at the end of the treatment course. C168851 Organism Attribute Age in Days at End of Treatment Course CL1378922 PCDC AGE_AT_COURSE_END Age at End of Treatment Course Age in Days at End of Treatment Course Age in Days at Treatment End Age in Days at End of Treatment Course Age of subject (in days) when their neutrophil count exceeded a threshold of 500 (ANC/mm3) during the course. C168852 Organism Attribute Age in Days at Course ANC 500 CL1378925 PCDC AGE_AT_COURSE_ANC_500 Age at Course ANC 500 Age in Days at Course ANC 500 Age in Days at Course ANC 500 Age of subject (in days) at the time of stem cell transplantation. C168853 Organism Attribute Age in Days at Stem Cell Transplant CL1378924 PCDC AGE_AT_SCT Age at Stem Cell Transplant Age in Days at Stem Cell Transplant Age in Days at Stem Cell Transplant Age of subject (in days) at the time of bone marrow analysis. C168854 Organism Attribute Age in Days at Bone Marrow Analysis CL1378919 Age in Days at Bone Marrow Analysis Age in Days at Bone Marrow Analysis Age of subject (in days) at assessment of minimal residual disease. C168855 Organism Attribute Age in Days at Measurable Residual Disease Assessment CL1378918 PCDC AGE_AT_MRD_ASSESSMENT Age at Measurable Residual Disease Assessment Age in Days at Measurable Residual Disease Assessment Age in Days at Minimal Residual Disease Assessment Age in Days at Measurable Residual Disease Assessment Age of subject (in days) when the response assessment was made. C168856 Organism Attribute Age in Days at Response Assessment CL1378921 PCDC AGE_AT_RESPONSE Age at Response Assessment Age in Days at Response Assessment Age in Days at Response Assessment Age of subject (in days) at the time of the Central Nervous System response assessment. C168857 Organism Attribute Age in Days at Central Nervous System Response Assessment CL1378920 Age in Days at Central Nervous System Response Assessment Age in Days at Central Nervous System Response Assessment Age of subject (in days) at the time of the myeloid sarcoma response assessment (excluding CNS involvement). C168858 Organism Attribute Age in Days at Myeloid Sarcoma Response CL1378931 Age in Days at Myeloid Sarcoma Response Age in Days at Myeloid Sarcoma Response Age of subject (in days) at the time of echocardiogram. C168859 Organism Attribute Age in Days at Echocardiogram CL1378930 Age in Days at Echocardiogram Age in Days at Echocardiogram Age of subject (in days) at the diagnosis of the secondary malignant neoplasm. C168860 Organism Attribute Age in Days at Secondary Malignancy Neoplasm CL1378933 PCDC AGE_AT_SMN Age at Secondary Malignancy Neoplasm Age in Days at Secondary Malignancy Neoplasm Age in Days at Secondary Malignant Neoplasm Age in Days at Secondary Malignancy Neoplasm Age of subject (in days) at the disease phase. C168972 Organism Attribute Age in Days at Disease Phase CL1378788 PCDC AGE_AT_DISEASE_PHASE Age at Disease Phase Age in Days at Disease Phase Age in Days at Disease Phase A group of individuals united by a common factor (e.g., geographic location, ethnicity, disease, age, sex). C17005 Population Group Population Group C1257890 CDISC-GLOSS GDC Any finite or infinite collection of subjects from which a sample is drawn for a study to obtain estimates for values that would be obtained if the entire population were sampled. [AMA style Manual] Population_Group Group Population Population Group Subpopulation population population group population_group Population Group A subjective and comparative term describing a lack of sufficient wealth (usually understood as capital, money, material goods, or resources especially natural resources) to live what is understood in a society as a "normal" life: for instance, to be capable of raising a healthy family, and especially educating children and participating in society. A person living in this condition of poverty is said to be poor. The meaning of "sufficient" varies widely across the different political and economic areas of the world. C17009 Group Attribute Poverty C0032854 Poverty Low Income Poor Poverty Poverty A geographic ancestral origin category that is assigned to a population group based mainly on physical characteristics that are thought to be distinct and inherent. C17049 Population Group Race C0034510 CDISC CDISC-GLOSS CTDC DIPG/DMG FDA GDC NICHD OORO PCDC SeroNet An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution. (NCI) An arbitrary classification of a taxonomic group that is a division of the human species. Race reported by the patient. This is important for research and health care policy using social determinants of health (SDOH). Race Patient Reported Race RACE Race Racial Group race Race A numeric representation of the elapsed time since birth at a specific point in time defined for the trial, used for study data tabulation. C170981 Organism Attribute Numeric Age for Data Tabulation CL1383250 Numeric Age for Data Tabulation Numeric Age for Data Tabulation The status of a person at a given time. C171086 Qualitative Concept Person Status CL1405327 Person Status Person Status A demographic parameter indicating a family's accumulated financial assets (monetary value of all possessions, minus debt). C171578 Qualitative Concept Household Wealth CL1405818 Household Wealth Household Wealth A leave of absence from work. C172444 Functional Concept Leave from Employment CL1407062 Leave Leave from Employment Leave from Employment The time that a woman takes off from work following the birth or adoption of a child. C172445 Functional Concept Maternity Leave C0086593 Maternity Leave Maternity Leave The time that a person takes off from work to care for their serious medical condition, or that of an eligible family member. C172446 Functional Concept Medical Leave CL1406364 Medical Leave Sick Leave Medical Leave The time that a parent takes off from work following the birth or adoption of a child. C172447 Functional Concept Family Leave C0086281 Family Leave Family Leave Age of subject in days. C172676 Organism Attribute Age-Days CL1406536 GDC Age in days Age-Days days to birth days_to_birth Age-Days Age of subject (in days) at the onset of the adverse event. C172677 Organism Attribute Age in Days at Onset Adverse Event CL1406539 PCDC AGE_AT_AE Age at Onset Adverse Event Age in Days at Onset Adverse Event Age in Days at Onset Adverse Event Age of subject (in days) when subject was off therapy or study. C172678 Organism Attribute Age in Days When Off Protocol Therapy or Study CL1406538 PCDC AGE_OFF Age When Off Therapy or Study Age in Days When Off Protocol Therapy or Study Age in Days When Off Protocol Therapy or Study Age of subject (in days) when the subject was lost to follow-up. C172679 Organism Attribute Age in Days When Lost to Follow-up CL1406541 PCDC AGE_LOST_TO_FOLLOW_UP Age When Lost to Follow-up Age in Days When Lost to Follow-up Age in Days When Lost to Follow-up Age of subject (in days) at the end of the total dose calculation. C172686 Organism Attribute Age in Days at End of Total Dose Calculation CL1406545 PCDC AGE_AT_TOTAL_DOSE_END Age at End of Total Dose Calculation Age in Days at End of Total Dose Calculation Age in Days at End of Total Dose Calculation Age of subject (in days) when the laboratory test was performed. C172691 Organism Attribute Age in Days at Time of Laboratory Test CL1406580 PCDC AGE_AT_LAB Age at Time of Laboratory Test Age in Days at Laboratory Test Age in Days at Time of Lab Test Age in Days at Time of Laboratory Test Age in Days at Time of Laboratory Test Age of subject (in days) at the start of the concomitant medication administration. C172692 Organism Attribute Age in Days at Start of Concomitant Medication Administration CL1406583 PCDC AGE_AT_MEDICATION_START Age at Start of Concomitant Medication Administration Age in Days at Medication Start Age in Days at Start of Concomitant Medication Administration Age in Days at Start of Concomitant Medication Administration Age of subject (in days) at the end of the concomitant medication administration. C172693 Organism Attribute Age in Days at End of Concomitant Medication Administration CL1406582 PCDC AGE_AT_MEDICATION_END Age at End of Concomitant Medication Administration Age in Days at End of Concomitant Medication Administration Age in Days at Medication End Age in Days at End of Concomitant Medication Administration Age of subject (in days) at the start of radiation therapy. C172695 Organism Attribute Age in Days at Radiation Therapy Course Start CL1406584 PCDC AGE_AT_RT_START Age at Radiation Therapy Course Start Age in Days at Radiation Therapy Course Start Age in Days at Radiation Therapy Start Age in Days at Radiation Therapy Course Start Age of subject (in days) at the end of radiation therapy. C172696 Organism Attribute Age in Days at End of Radiation Therapy CL1406587 PCDC AGE_AT_RT_END Age at End of Radiation Therapy Age in Days at End of Radiation Therapy Age in Days at Radiation Therapy End Age in Days at End of Radiation Therapy Age of subject (in days) at the start of the transfusion procedure. C172697 Organism Attribute Age in Days at Start of Transfusion Procedure CL1406586 PCDC AGE_AT_TMP_START Age at Start of Transfusion Procedure Age in Days at Start of Transfusion Procedure Age in Days at Start of Transfusion Procedure Age of subject (in days) at the start of the total dose calculation. C172698 Organism Attribute Age in Days at Start of Total Dose Calculation CL1406589 PCDC AGE_AT_TOTAL_DOSE_START Age at Start of Total Dose Calculation Age in Days at Start of Total Dose Calculation Age in Days at Start of Total Dose Calculation Age of subject (in days) at the start of the cellular immunotherapy. C173195 Organism Attribute Age in Days at Start of Cellular Immunotherapy CL1407254 PCDC AGE_AT_CIMT_START Age at Start of Cellular Immunotherapy Age in Days at Cellular Immunotherapy Start Age in Days at Start of Cellular Immunotherapy CIMT Age in Days at Start of Cellular Immunotherapy Indicates that a person has completed some formal schooling but did not start any formal schooling at the high school level (has not attended nor completed high school). C173723 Organism Attribute Less than High School Completion CL1407575 Less than High School Less than High School Completion Less than High School Completion Work undertaken for which wages are due. C173947 Functional Concept Paid Hours CL1407864 Paid Paid Hours Paid Hours Worked Paid Hours Work, or a period of leave, for which no wages are due. C173948 Functional Concept Unpaid Hours CL1407859 Unpaid Unpaid Hours Unpaid Hours Taken Unpaid Hours Insurance that is available through an employer that provides income in the event that an employee is unable to perform their work due to a disability. C173956 Intellectual Product Employer-sponsored Disability Insurance CL1407871 Employer-sponsored Disability Insurance Employer-sponsored Disability Insurance A physical parameter applied to vibration-controlled transient elastography to measure attenuation of shear wave velocity as a means for evaluating liver fibrosis or liver steatosis. C174123 Quantitative Concept Controlled Attenuation Parameter CL1412909 CAP Controlled Attenuation Parameter Controlled Attenuation Parameter The age at which illness-specific symptoms first began. C174273 Organism Attribute Age Symptom Started CL1412617 CDISC The age at which illness-specific symptoms first began. AGESYMST Age Symptom Started Age Symptoms Started Age at Symptom Onset Age at Symptom Start Symptom Onset Age Age Symptom Started An approximate determination of the weight of the fetus. C174372 Conceptual Entity Fetal Estimated Weight CL1411750 CDISC An approximate determination of the weight of the fetus. FTEWT Fetal Estimated Weight Fetal Estimated Weight Includes individuals of Mexican, Puerto Rican, Salvadoran, Cuban, Dominican, Guatemalan, and other Central or South American or Spanish culture or origin. C17459 Population Group Hispanic or Latino C0086409 CDISC CTDC DIPG/DMG FDA GDC OORO PCDC SeroNet A person of Mexican, Puerto Rican, Cuban, Central or South American or other Spanish culture or origin, regardless of race. (NCI) Hispanic hispanic or latino HISPANIC OR LATINO HISPANIC_OR_LATINO Hispanic Hispanic Populations Hispanic or Latino Hispanics or Latinos Latino Population Spanish Origin hispanic or latino Hispanic or Latino Characteristics of a person such as education and occupation, used to describe the person's position in stratification systems, access to services, etc. C17468 Qualitative Concept Socioeconomic Factors C0086996 SeroNet Socioeconomic_Factors Measured Social Factor Socioeconomic Factors Socioeconomic Status Socioeconomic Factors Age of subject (in days) at tumor assessment. C174997 Organism Attribute Age in Days at Tumor Assessment CL1412492 PCDC AGE_AT_TUMOR_ASSESSMENT Age at Tumor Assessment Age in Days at Tumor Assessment Age in Days at Tumor Assessment Age of subject (in days) at histology assessment. C175004 Organism Attribute Age In Days at Histology Assessment CL1412539 PCDC AGE_AT_HIST_ASSESSMENT Age In Days at Histology Assessment Age at Histology Assessment Age In Days at Histology Assessment Age of subject (in days) at immunohistochemistry assessment. C175006 Organism Attribute Age in Days at Immunohistochemistry CL1412545 PCDC AGE_AT_IHC Age at Immunohistochemistry Age in Days at Immunohistochemistry Age in Days at Immunohistochemistry Age of subject (in days) at procedure. C175008 Organism Attribute Age in Days at Procedure CL1412543 PCDC AGE_AT_PROCEDURE Age at Procedure Age in Days at Procedure Age in Days at Procedure Age of subject (in days) at adverse event resolution. C175043 Organism Attribute Age in Days at Adverse Event Resolution CL1412313 PCDC AGE_AT_AE_RESOLVED Age at Adverse Event Resolution Age in Days at Adverse Event Resolution Age in Days at Adverse Event Resolution Age of subject (in days) when the treatment was assigned. C175529 Organism Attribute Age in Days at Treatment Assignment CL1412902 PCDC AGE_AT_TXASSIGN Age at Treatment Assignment Age in Days at Treatment Assignment Age in Days at Treatment Assignment Age of subject (in days) at the time of the staging assessment. C177359 Organism Attribute Age in Days of Staging Assessment CL1643256 PCDC AGE_AT_STAGING Age at Staging Assessment Age in Days at Staging Assessment Age in Days of Staging Assessment Age in Days of Staging Assessment Age of subject (in days) at the time of the cytology test. C177369 Organism Attribute Age in Days at Cytology Test CL1643253 PCDC AGE_AT_CYTOLOGY Age at Cytology Test Age in Days at Cytology Test Age in Days at Cytology Test Age of subject (in days) at the diagnosis of growing teratoma syndrome. C177375 Organism Attribute Age in Days at Growing Teratoma Syndrome CL1643330 PCDC AGE_AT_GTS Age in Days at Growing Teratoma Syndrome Age in Days at Growing Teratoma Syndrome An indication that an individual is not working due to being laid off, but that it is only temporary. C177653 Functional Concept Temporary Leave CL1643483 Temporarily Laid Off Temporary Leave Temporary Leave Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. C17950 Population Group Ashkenazi Jew C0337704 CDISC GDC A person of Ashkenazi Jewish descent. One of two major ancestral groups of Jewish individuals, comprised of those whose ancestors lived in Eastern Europe (Germany, Poland, Russia). The other group is designated Sephardic Jews and includes those whose ancestors lived in North Africa, the Middle East, and Spain. Most Jews living in the United States are Ashkenazi Jews. Ashkenazi_Jew Ashkenazi Jew ASHKENAZI JEW Ashkenazi Jew Ashkenazim Ashkenazi Jew An indication of the years of schooling completed in graded public, private, or parochial schools, and in colleges, universities, or professional schools. C17953 Organism Attribute Education Level C0013658 ACC/AHA CDISC GDC NICHD OORO SeroNet Highest education attained. Highest level of education obtained. This is important for research and health care policy using social determinants of health (SDOH). Value should be as identified by patient. Highest level of education that a person has attained. Education_Level EDULEVEL Education Education Level Education Level Completed Educational Attainment Educational Level Level of Education Attained education level education_level Education Level Indicates that a person has attended technical school. C179907 Organism Attribute Technical School Attendance CL1662656 Technical School Technical School Attendance Technical School Attendance An employment arrangement that allows employees to perform the duties and responsibilities of their position from alternative worksites. C180631 Functional Concept Telework CL1440776 Remote Work Telecommuting Telework Telework Age at the time of diagnosis expressed in days. C181699 Organism Attribute Age in Days at Diagnosis CL1664969 GDC Age at Diagnosis Age in Days at Diagnosis age at diagnosis age_at_diagnosis Age in Days at Diagnosis Age at the in years at the index date. C181702 Organism Attribute Age in Years at Index Date CL1664794 GDC Age in Years at Index Date age at index age_at_index Age in Years at Index Date The age in years at which the relative of a subject was first diagnosed with cancer. C181704 Organism Attribute Age in Years of Patient Relative at Cancer Diagnosis CL1664798 GDC Age in Years of Patient Relative at Cancer Diagnosis relationship age at diagnosis relationship_age_at_diagnosis Age in Years of Patient Relative at Cancer Diagnosis The age of the subject when undescended testis was corrected. C181721 Organism Attribute Age at Undescended Testis Correction CL1664782 GDC Age at Undescended Testis Correction undescended testis corrected age undescended_testis_corrected_age Age at Undescended Testis Correction The weight in kilograms at the time of evaluation. C182173 Quantitative Concept Weight In Kilograms at Time of Evaluation CL1770898 DIPG/DMG Weight In Kilograms at Time of Evaluation Weight in kilograms at time of evaluation Weight In Kilograms at Time of Evaluation The weight of the patient at diagnosis. C182174 Quantitative Concept Weight at Diagnosis CL1770899 DIPG/DMG Weight at Diagnosis Weight at diagnosis Weight at Diagnosis Denotes a person having origins in any indigenous people of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment. The concept refers to population subgroups such as Eskimos, Aleuts, Inupiat, Yupik, Alutiiq, Egegik,and Pribilovian, Alaskan Athabascan, Tlingit, and Haida. The concept refers also to individuals who classify themselves as such. C18237 Population Group Alaska Native C0682125 CDISC The native people of Alaska. Alaska_Native ALASKA NATIVE Alaska Indian Alaska Indians Alaska Native Alaska Natives Alaska Native Age of subject (in days) at the end of the treatment cycle. C185316 Organism Attribute Age in Days at Cycle End CL1773580 PCDC AGE_AT_CYCLE_END Age at Cycle End Age in Days at Cycle End Age in Days at Cycle End Age of subject (in days) at the beginning of the treatment cycle. C185317 Organism Attribute Age in Days at Cycle Start CL1773583 PCDC AGE_AT_CYCLE_START Age at Cycle Start Age in Days at Cycle Start Age in Days at Cycle Start Age of subject (in days) at assessment of lesion. C185485 Organism Attribute Age in Days at Lesion Assessment CL1773679 PCDC AGE_AT_LESION_ASSESSMENT Age at Lesion Assessment Age in Days at Lesion Assessment Age in Days at Lesion Assessment Age of subject (in days) at the time of imaging test. C185622 Organism Attribute Age in Days at Imaging CL1773866 PCDC AGE_AT_IMAGING Age at Imaging Age in Days at Image Acquisition Age in Days at Imaging Age in Days at Imaging Age of subject (in days) at the time of the function test. C185624 Organism Attribute Age in Days at Function Test CL1773870 PCDC AGE_AT_FUNCTION_TEST Age at Function Test Age in Days at Function Test Age in Days at Function Test Age of subject (in days) since the protocol treatment modification. C185630 Organism Attribute Age in Days of Protocol Treatment Modification CL1773883 PCDC AGE_AT_MOD Age at Protocol Treatment Modification Age in Days at Protocol Treatment Modification Age in Days of Protocol Treatment Modification Age in Days of Protocol Treatment Modification Age of subject (in days) when the late effect evaluation was performed. C185670 Organism Attribute Age in Days at Late Effect Evaluation CL1773901 PCDC AGE_AT_LE_EVAL Age at Late Effect Evaluation Age in Days at Late Effect Evaluation Age in Days at Late Effect Evaluation Steady and sustainable economic growth in a financial system characterized by stable prices, low unemployment, and low inflation. C189175 Qualitative Concept Economic Stability C0681033 SeroNet Economic Stability Economic Stability The presence of low-cost, physically accessible, high quality educational institutions in a community. C189176 Qualitative Concept Education Access and Quality CL1794184 SeroNet Education Access and Quality Education Access and Quality The presence of low-cost, physically accessible, high quality medical care in a community. C189177 Qualitative Concept Healthcare Access and Quality CL1794188 SeroNet Healthcare Access and Quality Healthcare Access and Quality The presence of low-cost, physically accessible healthy food options in a community. C189178 Qualitative Concept Food Security CL1464624 SeroNet Food Security Food Security The effect of the physical environment of a bounded geographic territory on an individual residing within it. C189179 Qualitative Concept Neighborhood and Physical Environment CL1794187 SeroNet Neighborhood and Physical Environment Neighborhood and Physical Environment The effect of the social environment of a bounded geographic territory on a group of individuals residing within it. C189180 Qualitative Concept Society and Community CL1794186 SeroNet Society and Community Society and Community The age at onset of breast development. C189361 Organism Attribute Thelarche Age CL1794517 CDISC The age at onset of breast development. THLARAGE Thelarche Age Thelarche Age The age at onset of adrenal androgen-mediated secondary sexual characteristics. C189362 Organism Attribute Adrenarche Age CL1794516 CDISC The age at onset of adrenal androgen-mediated secondary sexual characteristics. ADRNRAGE Adrenarche Age Adrenarche Age Blood pressure within the right atrium. It is determined by the interaction of the heart's pumping ability (cardiac function) and the return of blood to the heart (return function). C190726 Clinical Attribute Right Atrial Pressure C0456165 Pra RAP Right Atrial Pressure Right Atrial Pressure The estimated height of the mean jugular venous waveform above the right atrium, as measured by observation of the bifid pulsation while the patient is supine and their neck is inclined at a 45 degree angle. C191459 Clinical Attribute Jugular Venous Pressure C0428897 ACC/AHA The estimated height of the mean jugular venous waveform above the right atrium, measured at a 45 degree angle. When expressed in cm without further description, the number should be recorded as written. When it is expressed as cm above the sternal angle, 5 cm should be added to the number recorded. JVP Jugular Venous Pressure Jugular venous pressure Jugular Venous Pressure The average blood pressure within the right atrium as measured from a pulmonary artery catheter. C191460 Clinical Attribute Mean Right Atrial Pressure CL1905300 ACC/AHA Mean right atrial pressure measured from pulmonary artery catheter Mean Right Atrial Pressure RA mean pressure Mean Right Atrial Pressure Age of a subject when molecular analysis was performed. C192055 Organism Attribute Age at Genetic Analysis CL1905340 AGE_AT_GENETIC_ANALYSIS Age at Genetic Analysis Age at Genetic Analysis The age of an individual when an event or observation was reported. C192236 Organism Attribute Age at Report CL1912550 OORO Age of the patient at the time associated with this instance of Patient Information. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record Age at Report Age at Report The age of an individual when the image was acquired. C192253 Organism Attribute Age at Image Acquisition CL1912535 OORO Age of the patient at the time associated with this instance of Image. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Image Acquisition Age at Image Acquisition Age at Image Acquisition The age of an individual when the laboratory test was conducted. C192254 Organism Attribute Age at Laboratory Test CL1912534 OORO Age of the patient at the time associated with this instance of Lab Result. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Lab Result Age at Laboratory Test Age at Laboratory Test The age of an individual when a diagnosis and staging was reported. C192255 Organism Attribute Age at Report at Diagnosis and Staging CL1912533 OORO Age of the patient at the time associated with this instance of Diagnosis and Staging. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record at Diagnosis and Staging Age at Report at Diagnosis and Staging Age at Report at Diagnosis and Staging The age of an individual when a diagnosis and staging of prostate cancer was reported. C192256 Organism Attribute Age at Report at Diagnosis and Staging of Prostate Cancer CL1912539 OORO Age of the patient at the time associated with this instance of Diagnosis and Staging Prostate Components. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record at Diagnosis and Staging of Prostate Cancer Age at Report at Diagnosis and Staging of Prostate Cancer Age at Report at Diagnosis and Staging of Prostate Cancer The age of an individual when the androgen deprivation therapy was initiated. C192257 Organism Attribute Age at Report of Androgen Deprivation Therapy CL1912538 OORO Age of the patient at the time associated with this instance of Systemic Therapy Drugs Used - Androgen Deprivation Therapy. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Androgen Deprivation Therapy Age at Report of Androgen Deprivation Therapy Age at Report of Androgen Deprivation Therapy The age of an individual when the charge was reported. C192258 Organism Attribute Age at Report of Charge CL1912537 OORO Age of the patient at the time associated with this instance of Charge. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Charge Age at Report of Charge Age at Report of Charge The age of an individual when the function test result was reported. C192259 Organism Attribute Age at Report of Function Test Result CL1912536 OORO Age of the patient at the time associated with this instance of Function Test Result. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Function Test Result Age at Report of Function Test Result Age at Report of Function Test Result The age of an individual when the immunotherapy was initiated. C192260 Organism Attribute Age at Report of Immunotherapy CL1912543 OORO Age of the patient at the time associated with this instance of Systemic Therapy Drugs Used - Immunotherapy. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Immunotherapy Age at Report of Immunotherapy Age at Report of Immunotherapy The age of an individual when the interventional procedure was reported. C192261 Organism Attribute Age at Report of Interventional Procedure CL1912542 OORO Age of the patient at the time associated with this instance of Interventional Procedure. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Interventional Procedure Age at Report of Interventional Procedure Age at Report of Interventional Procedure The age of an individual when the patient encounter was reported. C192262 Organism Attribute Age at Report of Patient Encounter CL1912541 OORO Age of the patient at the time associated with this instance of Patient Encounter. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Patient Encounter Age at Report of Patient Encounter Age at Report of Patient Encounter The age of an individual when the patient reported outcome was recorded. C192263 Organism Attribute Age at Report of Patient Reported Outcome CL1912540 OORO Age of the patient at the time associated with this instance of Patient Reported Outcome. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Patient Reported Outcome Age at Report of Patient Reported Outcome Age at Report of Patient Reported Outcome The age of an individual when the patient treatment outcome was reported. C192264 Organism Attribute Age at Report of Patient Treatment Outcome CL1912516 OORO Age of the patient at the time associated with this instance of Patient Treatment Outcome. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Patient Treatment Outcome Age at Report of Patient Treatment Outcome Age at Report of Patient Treatment Outcome The age of an individual when the performance score was reported. C192265 Organism Attribute Age at Report of Performance Score CL1912515 OORO Age of the patient at the time associated with this instance of Performance Score. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Performance Score Age at Report of Performance Score Age at Report of Performance Score The age of an individual when the provider reported toxicity was recorded. C192266 Organism Attribute Age at Report of Provider Reported Toxicity CL1912514 OORO Age of the patient at the time associated with this instance of Provider Reported Toxicity. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Provider Reported Toxicity Age at Report of Provider Reported Toxicity Age at Report of Provider Reported Toxicity The age of an individual when the radiation therapy course was reported. C192267 Organism Attribute Age at Report of Radiation Therapy Course CL1912513 OORO Age of the patient at the time associated with this instance of Radiation Therapy Course. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Radiation Therapy Course Age at Report of Radiation Therapy Course Age at Report of Radiation Therapy Course The age of an individual when the radiation therapy course event was reported. C192268 Organism Attribute Age at Report of Radiation Therapy Course Event CL1912520 OORO Age of the patient at the time associated with this instance of Radiation Therapy Course - Event. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Radiation Therapy Course Event Age at Report of Radiation Therapy Course Event Age at Report of Radiation Therapy Course Event The age of an individual when the radiation therapy course session was reported. C192269 Organism Attribute Age at Report of Radiation Therapy Course Session CL1912519 OORO Age of the patient at the time associated with this instance of Radiation Therapy Course - Session. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Radiation Therapy Course Session Age at Report of Radiation Therapy Course Session Age at Report of Radiation Therapy Course Session The age of an individual when the radiation therapy prescription was reported. C192270 Organism Attribute Age at Report of Radiation Therapy Prescription CL1912518 OORO Age of the patient at the time associated with this instance of Radiation Therapy Prescription. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Radiation Therapy Prescription Age at Report of Radiation Therapy Prescription Age at Report of Radiation Therapy Prescription The age of an individual when the reirradiation evaluation was reported. C192271 Organism Attribute Age at Report of Reirradiation Evaluation CL1912517 OORO Age of the patient at the time associated with this instance of ReIrradiation Evaluation. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Reirradiation Evaluation Age at Report of Reirradiation Evaluation Age at Report of Reirradiation Evaluation The age of an individual when the supportive medication was reported. C192272 Organism Attribute Age at Report of Supportive Medication CL1912524 OORO Age of the patient at the time associated with this instance of Supportive Medication. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Supportive Medication Age at Report of Supportive Medication Age at Report of Supportive Medication The age of an individual when the systemic therapy course was reported. C192273 Organism Attribute Age at Report of Systemic Therapy Course CL1912523 OORO Age of the patient at the time associated with this instance of Systemic Therapy Course. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Systemic Therapy Course Age at Report of Systemic Therapy Course Age at Report of Systemic Therapy Course The age of an individual when the systemic therapy cycle was reported. C192274 Organism Attribute Age at Report of Systemic Therapy Cycle CL1912522 OORO Age of the patient at the time associated with this instance of Systemic Therapy Cycle. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Systemic Therapy Cycle Age at Report of Systemic Therapy Cycle Age at Report of Systemic Therapy Cycle The age of an individual when the treated field in treated radiation therapy plan fraction was reported. C192275 Organism Attribute Age at Report of Treated Field in Treated Radiation Therapy Plan Fraction CL1912521 OORO Age of the patient at the time associated with this instance of Treated Field in Treated Radiation Therapy Plan Fraction. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Treated Field in Treated Radiation Therapy Plan Fraction Age at Report of Treated Field in Treated Radiation Therapy Plan Fraction Age at Report of Treated Field in Treated Radiation Therapy Plan Fraction The age of an individual when the treated radiation therapy plan was reported. C192276 Organism Attribute Age at Report of Treated Radiation Therapy Plan CL1912528 OORO Age of the patient at the time associated with this instance of Treated Radiation Therapy Plan - Fraction. This is calculated to 7 decimal places with respect to Date Of Birth, so that differences in time between events can be resolved to the second. Age is not a PHI restricted element for patients younger than 89. The Description of the Key Element specifies which time to use for the record in calculating age. Age At Record of Treated Radiation Therapy Plan Age at Report of Treated Radiation Therapy Plan Age at Report of Treated Radiation Therapy Plan Private health insurance obtained outside of one's employment, via direct purchasing of a policy. C192603 Intellectual Product Private Insurance Direct Purchase CL1912624 OORO Individual Health Insurance Plan Individual Health Plan Individual Insurance Plan Private Insurance Direct Purchase Private Insurance Direct Purchase A demographic parameter indicating the average amount of earnings made by a family in a particular population or/and during a particular period of time. C19308 Quantitative Concept Average Household Income C1510993 Average_Household_Income Average Household Income Average Household Income The number of children (including neonates) residing in the household. May be used as a demographics parameter, useful for identifying socio-economic groups. C19309 Quantitative Concept Number of Children in Household C1518468 CDISC The number of children (including neonates) residing in the household. Number_of_Children_in_Household CHLDHSHN Number of Children in Household Number of Children in Household The distinguishing qualities or prominent aspects of an individual person. C19332 Organism Attribute Personal Attribute C0681884 Personal_Attribute Personal Personal Attribute Subject Characteristics Personal Attribute Age of an individual at their first menstruation. C19666 Clinical Attribute Age at Menarche C1314691 CDISC The age at which the first menstruation event occurred. (NCI) Age_at_Menarche Age at Menarche MENARAGE Menarche Age Age at Menarche The age at which a woman gave birth to her first live child. C19667 Clinical Attribute Age at First Live Birth C1510831 Age_at_First_Live_Birth Age at First Full-Term Pregnancy Age at First Live Birth Age at First Live Birth Evidence of a body mass index of 30.0-30.9 in the adult. C197796 Finding Body Mass Index 30.0-30.9, Adult C2911051 mCode Body Mass Index 30.0-30.9, Adult Body mass index (BMI) 30.0-30.9, adult Body Mass Index 30.0-30.9, Adult Evidence of a body mass index of 31.0-31.9 in the adult. C197797 Finding Body Mass Index 31.0-31.9, Adult C2911052 mCode Body Mass Index 31.0-31.9, Adult Body mass index (BMI) 31.0-31.9, adult Body Mass Index 31.0-31.9, Adult Evidence of a body mass index of 32.0-32.9 in the adult. C197798 Finding Body Mass Index 32.0-32.9, Adult C2911053 mCode Body Mass Index 32.0-32.9, Adult Body mass index (BMI) 32.0-32.9, adult Body Mass Index 32.0-32.9, Adult Evidence of a body mass index of 33.0-33.9 in the adult. C197799 Finding Body Mass Index 33.0-33.9, Adult C2911054 mCode Body Mass Index 33.0-33.9, Adult Body mass index (BMI) 33.0-33.9, adult Body Mass Index 33.0-33.9, Adult Evidence of a body mass index of 34.0-34.9 in the adult. C197800 Finding Body Mass Index 34.0-34.9, Adult C2911055 mCode Body Mass Index 34.0-34.9, Adult Body mass index (BMI) 34.0-34.9, adult Body Mass Index 34.0-34.9, Adult Evidence of a body mass index of 35.0-35.9 in the adult. C197801 Finding Body Mass Index 35.0-35.9, Adult C2911056 mCode Body Mass Index 35.0-35.9, Adult Body mass index (BMI) 35.0-35.9, adult Body Mass Index 35.0-35.9, Adult Evidence of a body mass index of 36.0-36.9 in the adult. C197802 Finding Body Mass Index 36.0-36.9, Adult C2911057 mCode Body Mass Index 36.0-36.9, Adult Body mass index (BMI) 36.0-36.9, adult Body Mass Index 36.0-36.9, Adult Evidence of a body mass index of 37.0-37.9 in the adult. C197803 Finding Body Mass Index 37.0-37.9, Adult C2911058 mCode Body Mass Index 37.0-37.9, Adult Body mass index (BMI) 37.0-37.9, adult Body Mass Index 37.0-37.9, Adult Evidence of a body mass index of 38.0-38.9 in the adult. C197804 Finding Body Mass Index 38.0-38.9, Adult C2911059 mCode Body Mass Index 38.0-38.9, Adult Body mass index (BMI) 38.0-38.9, adult Body Mass Index 38.0-38.9, Adult Evidence of a body mass index of 39.0-39.9 in the adult. C197805 Finding Body Mass Index 39.0-39.9, Adult C2911060 mCode Body Mass Index 39.0-39.9, Adult Body mass index (BMI) 39.0-39.9, adult Body Mass Index 39.0-39.9, Adult Evidence of a body mass index of 40.0-44.9 in the adult. C197806 Finding Body Mass Index 40.0-44.9, Adult C2921312 mCode Body Mass Index 40.0-44.9, Adult Body mass index (BMI) 40.0-44.9, adult Body Mass Index 40.0-44.9, Adult Evidence of a body mass index of 45.0-49.9 in the adult. C197807 Finding Body Mass Index 45.0-49.9, Adult C2921313 mCode Body Mass Index 45.0-49.9, Adult Body mass index (BMI) 45.0-49.9, adult Body Mass Index 45.0-49.9, Adult Evidence of a body mass index of 50.0-59 9 in the adult. C197808 Finding Body Mass Index 50.0-59 9 , Adult C2921314 mCode Body Mass Index 50.0-59 9 , Adult Body mass index (BMI) 50.0-59.9, adult Body Mass Index 50.0-59 9 , Adult Evidence of a body mass index of 60.0-69.9 in the adult. C197809 Finding Body Mass Index 60.0-69.9, Adult C2921315 mCode Body Mass Index 60.0-69.9, Adult Body mass index (BMI) 60.0-69.9, adult Body Mass Index 60.0-69.9, Adult Evidence of a body mass index of 70 or greater in the adult. C197810 Finding Body Mass Index 70 or Greater, Adult CL1463075 mCode Body Mass Index 70 or Greater, Adult Body mass index (BMI) 70 or greater, adult Body Mass Index 70 or Greater, Adult Evidence of pediatric BMI greater than or equal to 95% for age. C197811 Finding BMI Pediatric, Greater Than or Equal To 95% for Age CL1913683 mCode BMI Pediatric, Greater Than or Equal To 95% for Age BMI pediatric, greater than or equal to 95% for age BMI Pediatric, Greater Than or Equal To 95% for Age Underrepresented Minority; any minority group presently underrepresented in biomedical and behavioral research. C19789 Population Group Underrepresented Minority C1519773 Underrepresented_Minority Underrepresented Minorities Underrepresented Minority Underrepresented Minority An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history. C19796 Organism Attribute Smoking Status C1519386 GDC Smoking_Status Current Tobacco and Nicotine Consumption Status Smoking Status tobacco smoking status tobacco_smoking_status Smoking Status The age of an individual at a disease phase. C198003 Organism Attribute Age at Disease Phase CL1913816 Age at Disease Phase Age at Disease Phase Age of subject at the last known exposure to a hazardous factor or substance. C198090 Organism Attribute Age at Last Exposure CL1913731 GDC Age at Last Exposure age at last exposure age_at_last_exposure Age at Last Exposure Indicates that a person has attended high school, but not to completion and did not receive a diploma. The person may have dropped out in or after 9th, 10th, or 11th grade. C198650 Organism Attribute Some High School, No Diploma CL1905805 GDC Some High School or Less Attended High School Some High School Some High School or Less Some High School, No Diploma Some High School, No Diploma The age of subject at the time of stem cell harvest. C198866 Organism Attribute Age at Stem Cell Harvest CL1906305 AGE_AT_SCT_HARVEST Age at Stem Cell Harvest Age at Stem Cell Harvest The actual minimum age of the subjects that have been entered in a clinical trial. C200031 Organism Attribute Actual Minimum Age of Subject CL1907311 CDISC Minimum age of subjects on the study populated as an integer. AGEMIN Actual Minimum Age of Subject Age Minimum Minimum Age of Subject, Actual Actual Minimum Age of Subject The actual maximum age of the subjects that have been entered in a clinical trial. C200032 Organism Attribute Actual Maximum Age of Subject CL1907310 CDISC Maximum age of subjects on the study populated as an integer. AGEMAX Actual Maximum Age of Subject Age Maximum Maximum Age of Subject, Actual Actual Maximum Age of Subject Age of a subject, in days, when a specimen was collected. C201284 Organism Attribute Age in Days at Specimen Collection CL1920638 Age in Days at Specimen Collection Age in Days at Specimen Collection The age at which first sexual intercourse occurred. C201480 Organism Attribute Age at First Sexual Intercourse CL1920398 CDISC The age at which first sexual intercourse occurred. Age at First Sexual Intercourse FSXIAGE Age at First Sexual Intercourse The age at which first oral sex occurred. C201481 Organism Attribute Age at First Oral Sex CL1920418 CDISC The age at which first oral sex occurred. Age at First Oral Sex FSXOAGE Age at First Oral Sex The age of a subject, in days, when a diagnosis of a recurring disease or condition was made. C201528 Organism Attribute Age in Days at Recurrence CL1920439 Age in Days at Recurrence Age in Days at Recurrence The age of an individual at the resolution of an adverse event. C201602 Organism Attribute Age at Adverse Event Resolution CL1920803 Age at Adverse Event Resolution Age at Adverse Event Resolution The age of an individual at the end of a cycle. C201603 Organism Attribute Age at Cycle End CL1920800 Age at Cycle End Age at Cycle End The age of an individual at the start of a cycle. C201604 Organism Attribute Age at Cycle Start CL1920801 Age at Cycle Start Age at Cycle Start The age of an individual at the time of a cytology test. C201605 Organism Attribute Age at Cytology Test CL1920798 Age at Cytology Test Age at Cytology Test The age of an individual at the end of a concomitant medication administration. C201606 Organism Attribute Age at End of Concomitant Medication Administration CL1920799 Age at End of Concomitant Medication Administration Age at End of Concomitant Medication Administration The age of an individual at the end of a treatment course. C201607 Organism Attribute Age at End of Treatment Course CL1920820 Age at End of Treatment Course Age at Treatment End Age at End of Treatment Course The age of an individual at the time of a function test. C201608 Organism Attribute Age at Function Test CL1920821 Age at Function Test Age at Function Test The age of an individual at the time of a histology assessment. C201609 Organism Attribute Age at Histology Assessment CL1920818 Age at Histology Assessment Age at Histology Assessment The age of an individual at the time of an imaging test. C201610 Organism Attribute Age at Imaging CL1920819 Age at Imaging Age at Imaging The age of an individual at the time of immunohistochemistry test. C201611 Organism Attribute Age at Immunohistochemistry CL1920816 Age at Immunohistochemistry Age at Immunohistochemistry The age of an individual at the time of their last known survival. C201612 Organism Attribute Age at Last Known Survival CL1920817 Age at Last Known Survival Age at Last Known Survival The age of an individual at the time of a measurable residual disease assessment. C201613 Organism Attribute Age at Measurable Residual Disease Assessment CL1920815 Age at Measurable Residual Disease Assessment Age at Measurable Residual Disease Assessment The age of an individual at the onset of an adverse event. C201614 Organism Attribute Age at Onset Adverse Event CL1920907 Age at Onset Adverse Event Age at Onset of Adverse Event Age at Onset Adverse Event The age of an individual at the time of a procedure. C201615 Organism Attribute Age at Procedure CL1920813 Age at Procedure Age at Procedure The age of an individual at the end of radiation therapy. C201616 Organism Attribute Age at End of Radiation Therapy CL1920814 Age at End of Radiation Therapy Age at End of Radiation Therapy The age of an individual at the start of a course of radiation therapy. C201617 Organism Attribute Age at Radiation Therapy Course Start CL1920811 Age at Radiation Therapy Course Start Age at Radiation Therapy Course Start The age of an individual at the time of a response assessment. C201618 Organism Attribute Age at Response Assessment CL1920812 Age at Response Assessment Age at Response Assessment The age of an individual at the diagnosis of a secondary malignant neoplasm. C201619 Organism Attribute Age at Secondary Malignancy Neoplasm CL1920809 Age at Secondary Malignancy Neoplasm Age at Secondary Malignant Neoplasm Age at Secondary Malignancy Neoplasm The age of an individual at the time of a staging assessment. C201621 Organism Attribute Age at Staging Assessment CL1920810 Age at Staging Assessment Age of Staging Assessment Age at Staging Assessment The age of an individual at the start of cellular immunotherapy. C201622 Organism Attribute Age at Start of Cellular Immunotherapy CL1920807 Age at Start of Cellular Immunotherapy Age at Start of Cellular Immunotherapy The age of an individual at the start of a concomitant medication administration. C201623 Organism Attribute Age at Start of Concomitant Medication Administration CL1920808 Age at Start of Concomitant Medication Administration Age at Start of Concomitant Medication Administration The age of an individual at the start of a transfusion procedure. C201625 Organism Attribute Age at Start of Transfusion Procedure CL1920835 Age at Start of Transfusion Procedure Age at Start of Transfusion Procedure The age of an individual at the start of a treatment course. C201628 Organism Attribute Age at Start of Treatment Course CL1920832 Age at Start of Treatment Course Age at Treatment Start Age at Start of Treatment Course The age of an individual at the time of stem cell transplantation. C201629 Organism Attribute Age at Stem Cell Transplant CL1920833 Age at Stem Cell Transplant Age at Stem Cell Transplant The age of an individual at the time of a laboratory test. C201630 Organism Attribute Age at Time of Laboratory Test CL1920830 Age at Time of Laboratory Test Age at Time of Laboratory Test The age of an individual at the time of a treatment assignment. C201631 Organism Attribute Age at Treatment Assignment CL1920831 Age at Treatment Assignment Age at Treatment Assignment The age of an individual at the time of a tumor assessment. C201632 Organism Attribute Age at Tumor Assessment CL1920828 Age at Tumor Assessment Age at Tumor Assessment The age of an individual at the time that vital signs were recorded. C201633 Organism Attribute Age at Vitals CL1920829 Age at Vitals Age at Vitals The age of an individual at the time of surgery. C201638 Organism Attribute Age at Surgery CL1920822 Age at Surgery Age at Surgery The age of an individual at the time of their last known disease status. C201639 Organism Attribute Age at Last Known Disease Status CL1920823 Age at Last Known Disease Status Age at Last Known Disease Status Age of subject at a known exposure to a hazardous factor or substance. C201913 Organism Attribute Age at Exposure CL1920749 Age at Exposure Age at Exposure Age of subject when molecular analysis was performed. C201921 Organism Attribute Age at Molecular Analysis CL1920770 Age at Molecular Analysis Age at Molecular Test Age at Molecular Analysis Universal health care coverage provided by any of Canada's 13 provinces to their citizens. C202074 Intellectual Product Canadian Provincial Medical Plan CL1921469 Canadian Provincial Health Insurance Plan Canadian Provincial Medical Plan Provincial Medical Plan Canadian Provincial Medical Plan Age of a subject when a specimen was collected. C202854 Organism Attribute Age at Specimen Collection CL1922318 Age at Biospecimen Collection Age at Sample Collection Age at Specimen Collection Age at Specimen Collection The age of a subject when a diagnosis of a recurring disease or condition was made. C202855 Organism Attribute Age at Recurrence CL1921681 Age at Recurrence Age at Recurrence Participation in Medicare without enrollment in a managed care plan. C203281 Intellectual Product Medicare Non-Managed Care C3530300 Medicare Non-Managed Care Medicare Non-Managed Care A voluntary outpatient prescription drug benefit for people with Medicare. Medicare drug plans are provided through private plans that contract with the federal government. C203287 Intellectual Product Medicare Drug Coverage C1955953 Medicare Drug Benefit Medicare Drug Coverage Medicare Part D Medicare Drug Coverage A type of Medicare non-managed plan not elsewhere listed or described. C203289 Intellectual Product Other Medicare Non-managed Care Plan CL1922013 Other Medicare Non-managed Care Plan Other Medicare Non-managed Care Plan Medical coverage for individuals who are eligible for both Medicare and Medicaid. Medicare is their primary source of health insurance coverage, and Medicaid, jointly funded by federal and state governments, provides supplemental coverage. C203291 Intellectual Product Dual Eligible Health Plan CL1922053 Dual Eligible Health Plan Dual-eligible Medicare/Medicaid Health Plan Dual Eligible Health Plan A managed care plan for individuals who qualify for both Medicare and Medicaid and who qualify for a special needs program. C203292 Intellectual Product Dual Eligible Special Needs Plan CL1922054 D-SNP Dual Eligible Special Needs Plan Dual-eligible Special Needs Plan Dual Eligible Special Needs Plan A managed care plan that fully integrates care under a single managed care organization for individuals who qualify for both Medicare and Medicaid and who qualify for a special needs program. C203293 Intellectual Product Fully Integrated Dual Eligible Special Needs Plan CL1922051 FIDE-SNP Fully Integrated Dual Eligible Special Needs Plan Fully Integrated Dual Eligible Special Needs Plan A Medicare coverage plan not elsewhere listed or described. C203294 Intellectual Product Other Medicare Plan CL1922052 Other Medicare Plan Other Medicare Plan Medicaid plans or services not elsewhere listed or described. C203298 Intellectual Product Other Medicaid Plan or Service CL1922049 Other Medicaid Plan or Service Other Medicaid Plan or Service A Medicaid managed care plan not elsewhere listed or described. C203299 Intellectual Product Other Medicaid Managed Care C3530291 Other Medicaid Managed Care Other Medicaid Managed Care Medicaid medical coverage that is not acquired through a managed care system or plan. C203300 Intellectual Product Medicaid Non-managed Care Plan C3530290 Medicaid Non-managed Care Plan Medicaid Non-managed Care Plan A health insurance program that provides health coverage to eligible children, through both Medicaid and separate Children's Health Insurance programs (CHIP). CHIP is administered by states, according to federal requirements. The program is funded jointly by states and the federal government. C203301 Intellectual Product Medicaid State-sponsored Children's Health Insurance Program C3530289 Medicaid State-sponsored Children's Health Insurance Program Medicaid/SCHIP SCHIP State-Sponsored Children's Health Insurance Program Medicaid State-sponsored Children's Health Insurance Program Medicaid services for individuals over 65, individuals with physical disabilities, individuals with intellectual disabilities, and chronically ill children. It is available to these participants based on medical necessity and technical and financial eligibility, and covers care in home, community-based settings, and in institutions. C203304 Intellectual Product Medicaid Long Term Services and Supports CL1922336 LTSS Medicaid LTSS Medicaid Long Term Services and Supports Medicaid Long Term Services and Supports Dental service coverage paid through Medicaid. It is made available to all enrolled children through the Children's Health Insurance Program (CHIP), but states choose whether to provide dental benefits for adults. C203305 Intellectual Product Medicaid Dental Coverage CL779166 Medicaid Dental Medicaid Dental Care Medicaid Dental Coverage Medicaid Dental Coverage The age of an individual at the start of a specific time period. C203404 Organism Attribute Age at Start of Time Period CL1922629 Age at Start of Time Period Age at Start of Time Period The age of an individual at the end of a specific time period. C203405 Organism Attribute Age at End of Time Period CL1922628 Age at End of Time Period Age at End of Time Period A managed care option for TRICARE enrollees. C203471 Intellectual Product TRICARE Prime CL1922684 TRICARE Prime TRICARE Prime A managed healthcare plan that requires the enrollee to choose a doctor from a limited number of in-network providers. It was replaced by TRICARE Select on January 1, 2018. C203472 Intellectual Product TRICARE Extra CL1922683 RICARE Extra - PPO TRICARE Extra TRICARE Extra A non-managed care plan that allows individuals to manage their own health care, with the ability to seek care from any TRICARE-authorized provider they choose. It was replaced by TRICARE Select on January 1, 2018. C203474 Intellectual Product TRICARE Standard C3530200 TRICARE Standard TRICARE Standard - FFS TRICARE Standard - Fee For Service TRICARE Standard A dual-coverage healthcare plan for individuals who are TRICARE-eligible and have Medicare Part A and B. Medicare pays its portion first and sends the claim to the TRICARE For Life claims processor. C203475 Intellectual Product TRICARE For Life CL1922672 TFL TRICARE For Life TRICARE For Life A premium-based plan, available worldwide, for members and their families. Members may see in-network providers, out-of-network providers, or receive care at a military hospital. C203476 Intellectual Product TRICARE Reserve Select C3530280 TRICARE Reserve Select TRICARE Reserve Select A self-managed, preferred provider organization (PPO) plan available for enrolles in the United States. C203477 Intellectual Product TRICARE Select CL1922674 TRICARE Select TRICARE Select A contracted TRICARE program under which the TRICARE Prime benefit is offered to eligible military beneficiaries. The Uniformed Services Family Health Plan requires beneficiaries to enroll and is offered through six participating non-profit plans, each serving different regions of the country. C203478 Intellectual Product Uniformed Services Family Health Plan CL1922673 USFHP Uniformed Services Family Health Plan Uniformed Services Family Health Plan A type of dental plan that's not included as part of a health plan. They can be obtained through the Affordable Care Act Marketplace or other marketplaces. C203480 Intellectual Product Stand-Alone Dental Plan CL1922675 Stand-Alone Dental Plan Stand-Alone Dental Plan A medical coverage program that provides payment authorization for eligible veterans to obtain routine medical treatment services through non-VA health care providers. C203483 Intellectual Product VA Fee Basis Medical Program CL1922668 VA Fee Basis Medical Program VA Fee Basis Medical Program A medical program for veterans living or traveling abroad. It will pay for health care services, medications, and durable medical equipment for service-connected conditions and conditions associated with and held to be aggravating a service-connected condition. C203484 Intellectual Product VA Foreign Medical Program CL1922667 FMP Foreign Fee Foreign Medical Program VA Foreign Medical Program VA Foreign Medical Program VA-financed health care benefits to women Vietnam Veterans' birth children who the Veterans Benefits Administration (VBA) has determined to have a covered birth defect. This program is not a comprehensive health care plan and only covers those services necessary for the treatment of a covered birth defect and associated medical conditions. C203491 Intellectual Product Children of Women Vietnam Veterans Health Care Benefits Program C3530266 CWVV Children of Women Vietnam Veterans Children of Women Vietnam Veterans (CWVV) Children of Women Vietnam Veterans Health Care Benefits Program Children of Women Vietnam Veterans Health Care Benefits Program A health care plan that allows the enrollee to see any healthcare provider, without requiring a primary care doctor or referrals, and provides compensation for a set portion of the costs. C203495 Intellectual Product Fee for Service Healthcare Plan CL1922717 FFS Fee for Service Healthcare Plan Indemnity Health Insurance Indemnity Health Insurance Plan Fee for Service Healthcare Plan Health care coverage for civilian employees of the United States federal government, retirees, and their families. Plan options include Fee-For-Service, Health Maintenance Organization, High Deductible, and Consumer-Driven Health Plans (HMO, PPO, etc.). C203496 Intellectual Product Federal Employees Health Benefits Program CL1922714 FEHB Federal Employee Health Plan Federal Employees Health Benefits Program Federal Employees Health Benefits Program Benefits provided by the Department of Veterans Affairs (VA) to certain Korea and Vietnam Veterans' birth children who have been diagnosed with spina bifida. It provides monetary allowances, vocational training and rehabilitation, and VA-financed health care benefits. C203586 Intellectual Product Spina Bifida Health Care Benefits Program C3530267 SBHCBP Spina Bifida Health Care Benefits Program Spina Bifida Health Care Program (SB) Spina Bifida Health Care Benefits Program Private health insurance coverage purchased by tribal consortia to provide health care coverage in addition to those provided for Indian Health Service beneficiaries. C203591 Intellectual Product Tribally-Sponsored Health Insurance Program C3530260 Indian Tribe - Sponsored Coverage T-SHIP Tribally-Sponsored Health Insurance Program Tribally-Sponsored Health Insurance Program The length of a person's life, stated in weeks since birth. C203602 Organism Attribute Age-Weeks CL1922471 Age in weeks Age-Weeks Age-Weeks A type of health insurance where an organization funds all of the costs. These plans are subject to the rules established by the Employee Retirement Income and Security Act of 1974 (ERISA). C203604 Intellectual Product Self-funded Insurance Plan CL1922473 Self-funded Health Insurance Self-funded Health Insurance Plan Self-funded Insurance Plan Self-insured (ERISA) Self-insured Group Health Plan Self-funded Insurance Plan A health care plan where a company funds their employee benefit plan but hire an outside vendor to administer it. C203605 Intellectual Product Administrative Services Only Health Plan CL1922472 ASO Health Plan Administrative Services Only (ASO) Plan Administrative Services Only Health Plan Administrative Services Only Health Plan Insurance that provides income in the event that a policyholder is prevented from working and earning an income due to a disability. C203606 Intellectual Product Disability Insurance C0282497 Disability Insurance Disability Insurance Insurance that covers the care needed for chronic medical conditions and disabilities. Long-term care insurance covers the costs of home care, nursing home, assisted living, or adult day care. C203607 Intellectual Product Long-term Care Insurance C0021688 Long-term Care Insurance Long-term Care Insurance An insurance policy that covers a specialized risk or cost that may not otherwise be covered by other existing policies. C203639 Intellectual Product Specialized Stand-Alone Insurance Plan CL1649188 Specialized Stand-Alone Insurance Plan Specialized Stand-Alone Plan Standalone Insurance Standalone Insurance Policy Specialized Stand-Alone Insurance Plan Health insurance that covers routine dental care as well as dental procedures. C203640 Intellectual Product Dental Insurance C0021681 Dental Dental Insurance Dental Insurance Health insurance that covers the maintenance of eye health and visual acuity. C203641 Intellectual Product Vision Insurance CL932299 Vision Vision Insurance Vision Insurance Insurance that helps pay for the repair of vehicle damage that results from accidents or vandalism, loss due to theft, and for liability against the result of accidents. C203642 Intellectual Product Automobile Insurance C4224067 Auto Insurance Auto Insurance (includes no fault) Automobile Insurance Automobile Insurance Insurance designed to protect the holder from claims related to others' bodily injury, property damage, and more. C203643 Intellectual Product Liability Insurance C0021686 Legal Liability / Liability Insurance Legal Liability Coverage Liability Coverage Liability Insurance Liability Insurance The age of an individual at the start of a medication administration. C204128 Organism Attribute Age at Start of Medication Administration CL1926413 Age at Start of Medication Administration Age at Start of Medication Administration The age of an individual at the end of a medication administration. C204129 Organism Attribute Age at End of Medication Administration CL1926412 Age at End of Medication Administration Age at End of Medication Administration A health insurance plan offered by an employer, union, or association to its members while they are still working. C204746 Intellectual Product Group Health Insurance C0679935 Group Health Insurance Group Health Insurance Plan Group Health Plan Group Health Insurance A type of employer-sponsored health insurance plan. The employer pays a monthly premium to a commercial insurance company based on how many employees are enrolled in the health plan. C204747 Intellectual Product Fully-insured Health Insurance CL1926973 Fully-insured Group Health Plan Fully-insured Health Insurance Fully-insured Health Plan Fully-insured Health Insurance A health insurance plan that covers groups with 2-50 employees. Depending on the state, employers with one employee or as many as 100 may also qualify. C204748 Intellectual Product Small Group Health Insurance CL1926972 Small Group Health Insurance Small Group Health Insurance Plan Small Group Health Plan Small Group Health Insurance A health insurance plan that covers groups with at least 51 employees. C204749 Intellectual Product Large Group Health Insurance CL1926971 Large Group Health Insurance Large Group Health Insurance Plan Large Group Health Plan Large Group Health Insurance Denotes the inhabitants of Somalia, a person from there, or their descendants elsewhere. C205482 Population Group Somali C0337847 CDISC A person having origins in any of the original peoples of Somalia. SOMALI Somali Somalian Somali An individual or their descendants with origins in Ghana. C205483 Population Group Ghanian C0337834 CDISC A person having origins in any of the original peoples of Ghana. GHANAIAN Ghanian Ghanian Denotes a person from El Salvador. C205485 Population Group Salvadoran C1171364 CDISC A person having origins in any of the original peoples of El Salvador. SALVADORAN Salvadoran Salvadorian Salvadoran Denotes a person from Guatemala. C205486 Population Group Guatemalan C1171343 CDISC A person having origins in any of the original peoples of Guatemala. GUATEMALAN Guatemalan Guatemalan Denotes a person from Honduras. C205487 Population Group Honduran C1171345 CDISC A person having origins in any of the original peoples of Honduras. HONDURAN Honduran Honduran Denotes a person from Colombia. C205488 Population Group Colombian C1553372 CDISC A person having origins in any of the original peoples of Columbia. COLOMBIAN Colombian Columbian Colombian Denotes a person from Morocco. C205489 Population Group Moroccan C5772638 CDISC A person having origins in any of the original peoples of Morocco. MOROCCAN Moroccan Moroccan Denotes a person from Yemen. C205490 Population Group Yemeni C5772237 CDISC A person having origins in any of the original peoples of Yemen. YEMENI Yemeni Yemeni Denotes a member of the Kurdish people. C205491 Population Group Kurdish C0683978 CDISC A person from the Kurdish ethnic group. KURDISH Kurd Kurdish Kurdish Individuals from the Congo Basin, Republic of the Congo and the Democratic Republic of the Congo. C205493 Population Group Congolese C0337830 CDISC A person having origins in any of the original peoples of the Democratic Republic of the Congo . CONGOLESE Congolese Congolese Indicates that an individual completed either 6 or 8 grades of school. C205684 Organism Attribute Completed 6 or 8 Grades CL1928381 6th or 8th Grade Completion Completed 6 or 8 Grades Completion of first 6 or 8 grades of education Completed 6 or 8 Grades Indicates that completion of middle school is an individual's highest level of educational achievement. C205685 Organism Attribute Middle School Completion CL1928380 Middle School Completion Middle School Completion The protocol-defined age of subjects within the study design population. C207450 Intellectual Product Study Design Population Planned Age CL1929407 CDISC The anticipated age of subjects within the study design population. Study Design Population Planned Age Study Design Population Planned Age The protocol-defined age of subjects within the study cohort. C207545 Organism Attribute Study Cohort Planned Age CL1929440 CDISC The anticipated age of subjects within the study cohort. Study Cohort Planned Age Study Cohort Planned Age The anticipated age of subjects within the population definition. C207701 Organism Attribute Population Definition Planned Age CL1929915 CDISC The anticipated age of subjects within the population definition. Population Definition Planned Age Population Definition Planned Age A person from a specified Chinese ethnic group. C209364 Population Group Chinese Ethnic Group CL1935939 Chinese Ethnic Group Chinese Ethnic Group Denotes a person from or of Costa Rica. C209379 Population Group Costa Rican C0239127 Costa Rican Costa Rican A term, of literary origin, that signifies the Hispanic people of the New World. C209380 Population Group La Raza C1553369 La Raza La Raza An identifier for people of Mexican descent born in the United States. C209381 Population Group Chicano CL1935926 Chicano Chicano Denotes a person from or of the Basque region of southern Spain. C209382 Population Group Basque C1553367 Basque Spanish Basque Basque Denotes a person from or of the Canary Islands autonomous region of Spain. C209383 Population Group Canarian C1553366 Canarian Canary Islander Canarian Denotes a person from or of the Valencian Community of Spain. C209385 Population Group Valencian C1553365 Valencian Valencian Denotes a person from or of the Galicia region of Spain. C209386 Population Group Galician C1553364 Galician Gallego Galician Denotes a person from or of the Balearic Islands autonomous region of Spain. C209387 Population Group Balearic Islander CL1935914 Balearic Islander Balearic Islander Denotes a person from or of the Catalonia region of Spain. C209388 Population Group Catalonian C1553362 Catalonian Catalonian Denotes a person from or of the Castile region of Spain. C209389 Population Group Castilian C5772420 Castilian Castilian Denotes a person from or of the Asturias autonomous region of Spain. C209390 Population Group Asturian C1553360 Asturian Asturian Denotes a person from or of the Andalusia autonomous region of Spain. C209391 Population Group Andalusian C1553359 Andalusian Andalusian A person having origins in any of the original peoples of the Caribbean. C209448 Population Group Caribbean Race C1331005 CDISC A person having origins in any of the original peoples of the Caribbean. CARIBBEAN Caribbean Race Indigenous Caribbean Caribbean Race A person of African and Latino descent. C209542 Population Group Afro-Latino CL1936125 CDISC A person of African and Latino descent. AFRO-LATINO Afro-Latino Black Latino Afro-Latino Any of the peoples in the Americas and Spain who speak Spanish or are descended from Spanish-speaking communities. C209543 Population Group Hispanic C0019576 CDISC Any of the peoples in the Americas and Spain who speak Spanish or are descended from Spanish-speaking communities. HISPANIC Hispanic Hispanic A person with origins from anywhere in Latin America (Mexico, South and Central America) and/or the Caribbean. C209544 Population Group Latino C0949335 CDISC A person with origins from anywhere in Latin America (Mexico, South and Central America) and/or the Caribbean. LATINO LatinX Latina Latino Latino A person of Latino and Caribbean descent. C209545 Population Group Latino-Caribbean CL1936126 CDISC A person of Latino and Caribbean descent. LATINO-CARIBBEAN Latin Caribbean Latino-Caribbean Latino-Caribbean A person having origins in any of the original peoples of Aruba. C209663 Population Group Aruban C5772187 CDISC A person having origins in any of the original peoples of Aruba. ARUBAN Aruban Aruban A person having origins in any of the original peoples of Belize. C209664 Population Group Belizean C5772507 CDISC A person having origins in any of the original peoples of Belize. BELIZEAN Belizean Belizean A person having origins in any of the original peoples of Bermuda. C209665 Population Group Bermudan CL1936579 CDISC A person having origins in any of the original peoples of Bermuda. BERMUDAN Bermudan Bermudan A person whose ancestry is from one or more of the indigenous African peoples of South Africa. C209666 Population Group Black South African CL1936580 CDISC A person whose ancestry is from one or more of the indigenous African peoples of South Africa. BLACK SOUTH AFRICAN Black South African Black South African A person having origins in any of the original peoples of Brazil. C209667 Population Group Brazilian C0238815 CDISC A person having origins in any of the original peoples of Brazil. BRAZILIAN Brazilian Brazilian A person having origins in any of the original peoples of Cabo Verde (Cape Verde). C209668 Population Group Cabo Verdean C5772452 CDISC A person having origins in any of the original peoples of Cabo Verde (Cape Verde). CABO VERDEAN Cabo Verdean Cape Verdean Cabo Verdean A person having origins in any of the original peoples of the Cayman Islands. C209669 Population Group Cayman Islander CL1936581 CDISC A person having origins in any of the original peoples of the Cayman Islands. CAYMAN ISLANDER Cayman Islander Cayman Islander A person having origins in any of the original peoples of Comoros. C209670 Population Group Comorian C5772571 CDISC A person having origins in any of the original peoples of Comoros. COMORIAN Comorian Comorian A person having origins in any of the original peoples of Guyana. C209671 Population Group Guyanese CL1936582 CDISC A person having origins in any of the original peoples of Guyana. GUYANESE Guyanese Guyanese A person having origins in the original Latin American Indian people. C209672 Population Group Latin American Indian CL1936583 CDISC The native people of Latin America (Mexico, South and Central America). LATIN AMERICAN INDIAN Latin American Indian Latin American Indian A person having origins in any of the original peoples of Mauritania. C209673 Population Group Mauritanian C5772580 CDISC A person having origins in any of the original peoples of Mauritania. MAURITANIAN Mauritanian Mauritanian A person having origins in any of the original peoples of Suriname. C209674 Population Group Surinamese CL1936560 CDISC A person having origins in any of the original peoples of Suriname. SURINAMESE Surinamese Surinamese The age at which puberty began. C209679 Organism Attribute Puberty Age CL1936565 CDISC The age at which puberty began. PUBAGE Puberty Age Puberty Age A person having origins in the original Georgetown people. C210444 Population Group Georgetown C1555201 Georgetown Georgetown (Eastern Tribes) Georgetown A person having origins in the original Barona Group of Capitan Grande Band of Mission Indians of the Barona Reservation, California people. C210596 Population Group Barona Group of Capitan Grande Band of Mission Indians of the Barona Reservation, California CL1939908 Barona Group of Capitan Grande Band of Mission Indians of the Barona Reservation Barona Group of Capitan Grande Band of Mission Indians of the Barona Reservation, California Barona Group of Capitan Grande Band of Mission Indians of the Barona Reservation, California A person having origins in the original Viejas Group of Capitan Grande Band of Mission Indians of the Viejas Reservation, California people. C210597 Population Group Viejas Group of Capitan Grande Band of Mission Indians of the Viejas Reservation, California CL1937376 Viejas (Baron Long) Group of Capitan Grande Band of Mission Indians of the Viejas Reservation, California) Viejas Group of Capitan Grande Band of Mission Indians of the Viejas Reservation, California Viejas Group of Capitan Grande Band of Mission Indians of the Viejas Reservation, California A member of the Jewish faith. C211623 Population Group Jewish C0178443 Jew Jewish Jewish A member of the Jewish faith who is descendent from ancestors that lived in North Africa and Asia, including the Middle East. C211624 Population Group Mizrahi Jew CL1938016 Mizrahi Mizrahi Jew Mizrahim Mizrahi Jew Individuals with origins in any of the Black racial groups of the Caribbean islands. C211625 Population Group Black Caribbean CL1938015 Black Caribbean Black Caribbean Denotes a person whose ancestry is in any of the Caribbean islands and descended from Spanish-speaking communities. C211626 Population Group Caribbean Hispanic CL1938017 Caribbean Hispanic Caribbean Hispanic Denotes a person whose ancestry is in any of the countries of the eastern part of the African continent: Burundi, Comoros, Djibouti, Ethiopia, Eritrea, Kenya, Rwanda, Seychelles, Somalia, South Sudan, Sudan, Tanzania, and Uganda. C211627 Population Group East African C0238603 East African East African Denotes a person whose ancestry is in any of the countries of the western part of the African continent: Benin, Burkina Faso, Cameroon, Cabo Verde, Chad, Côte d'Ivoire, Equatorial Guinea, The Gambia, Ghana, Guinea, Guinea-Bissau, Liberia, Mali, Mauritania, Niger, Nigeria, Senegal, Sierra Leone, and Togo. C211628 Population Group West African C0238606 West African West African Denotes a person whose ancestry is in any of the Central or South American countries and descended from Spanish-speaking communities. C211629 Population Group South or Central American Hispanic CL1938018 South / Central American Hispanic South or Central American Hispanic South or Central American Hispanic Denotes a black person whose ancestry is in any African country. C211630 Population Group Black African CL1938009 Black / African Black African Black African Individuals with origins in any of the original peoples of North America. C211631 Population Group Indigenous North American C0021208 Indigenous North American Indigenous North American Denotes a person whose ancestry is in any of the countries located on the Arabian Peninsula. C211633 Population Group Arabian Peninsula Arab CL1938011 Arab Peninsula Arabian Peninsula Arab Arabian Peninsula Arab Denotes a person whose ancestry is in any of the countries located in or around the eastern half or third of the Mediterranean Sea. C211634 Population Group Eastern Mediterranean CL1938010 East Mediterranean Eastern Mediterranean Eastern Mediterranean Denotes a person whose ancestry is in Russia or any of the countries of the former Soviet Union. C211635 Population Group Russian or Former Soviet Union CL1938012 Russian or Former Soviet Union Russian or Former Soviet Union Denotes a person whose ancestry is in any of the countries of the southern region of Europe, especially the Iberian Peninsula, the Apennine Peninsula, and the Balkan Peninsula. C211636 Population Group Southern European C0239311 Southern European Southern European The age of an individual at the time of an assessment. C213227 Organism Attribute Age at Assessment CL1939214 Age at Assessment Age at Assessment The age of an individual at the time of an event. C213228 Organism Attribute Age at Event CL1939215 Age at Event Age at Event The age of a subject, in days, at the last known disease status. C213732 Organism Attribute Age in Days at Last Known Disease Status CL1939500 Age in Days at Last Known Disease Status Age in Days at Last Known Disease Status The age of a subject, in days, at the time of stem cell harvest. C213733 Organism Attribute Age in Days at Stem Cell Harvest CL1939501 Age in Days at Stem Cell Harvest Age in Days at Stem Cell Harvest The age, in days, at which death occurred. C213734 Organism Attribute Age in Days at Death CL1939826 Age in Days at Death Age in Days at Death The age of a subject, in days, at the time of follow-up. C213735 Organism Attribute Age in Days at Follow-up CL1939827 Age in Days at Follow-up Age in Days at Followup Age in Days at Follow-up The age of a subject, in days, when a diagnosis of disease progression or recurrence was made. C213736 Organism Attribute Age in Days at Progression or Recurrence CL1939824 Age in Days at Progression or Recurrence Age in Days at Progression or Recurrence The age of a subject, in days, at the time of the most recent follow-up. C213864 Organism Attribute Age in Days at Last Follow-up CL1939877 Age in Days at Last Follow-up Age in Days at Last Follow-up The age of a subject, in days, at the time of the first radiation therapy treatment. C213907 Organism Attribute Age in Days at First Radiation Therapy CL1944139 Age in Days at First Radiation Therapy Age in Days at First Radiotherapy Age in Days at First Radiation Therapy The age of a subject, in days, at the time of the most recent radiation therapy treatment. C213908 Organism Attribute Age in Days at Last Radiation Therapy CL1944142 Age in Days at Last Radiation Therapy Age in Days at Last Radiotherapy Age in Days at Last Radiation Therapy The age of a subject, in days, at the time of the first chemotherapy treatment. C213909 Organism Attribute Age in Days at First Chemotherapy CL1944141 Age in Days at First Chemotherapy Age in Days at First Chemotherapy The age of a subject, in days, at the time of the most recent monoclonal antibody treatment. C213910 Organism Attribute Age in Days at Last Monoclonal Antibody Treatment CL1944136 Age in Days at Last Monoclonal Antibody Treatment Age in Days at Last Monoclonal Antibody Treatment The age of a subject, in days, at the time of exposure. C214504 Organism Attribute Age in Days at Exposure CL1943971 Age in Days at Exposure Age in Days at Exposure The age of a subject, in days, at the time of genetic analysis. C214505 Organism Attribute Age in Days at Genetic Analysis CL1943980 Age in Days at Genetic Analysis Age in Days at Genetic Testing Age in Days at Genetic Analysis The age of a subject, in days, at the start of a molecular analysis. C214796 Organism Attribute Age in Days at Molecular Analysis Start CL1944216 Age in Days at Molecular Analysis Start Age in Days at Molecular Test Start Age in Days at Molecular Analysis Start The age of a subject, in days, at the end of a molecular analysis. C214797 Organism Attribute Age in Days at Molecular Analysis Stop CL1944218 Age in Days at Molecular Analysis End Age in Days at Molecular Analysis Stop Age in Days at Molecular Test End Age in Days at Molecular Test Stop Age in Days at Molecular Analysis Stop An indication that an individual's age is or was greater than 89 years. C214961 Organism Attribute Age Greater than 89 Years CL1944338 Age Greater than 89 Years Age Over 89 Age Greater than 89 Years The age at which a woman gave birth to her first child. C215215 Organism Attribute Age at First Birth CL1945012 Age at First Birth Age at First Birth An indication that an individual's age is or was 90 or greater. C215216 Organism Attribute Age 90 or Over CL1945013 90 or Greater 90 or Older 90 or Over Age 90 or Greater Age 90 or Over Age 90 or Over Age of subject (in days) when a symptom is first noticed. C215689 Organism Attribute Age in Days at Symptom Start CL1945262 Age in Days at Symptom Onset Age in Days at Symptom Start Age in Days at Symptom Start Age of subject (in days) at their last bevacizumab (Avastin) treatment prior to a scan. C216942 Organism Attribute Age in Days at Last Bevacizumab Treatment Prior to Scan CL1946107 Age in Days at Last Avastin Treatment Prior to Scan Age in Days at Last Bevacizumab Treatment Prior to Scan Age in Days at Last Bevacizumab Treatment Prior to Scan Age of subject (in days) at their other treatment. C216943 Organism Attribute Age in Days at Other Treatment CL1946108 Age in Days at Other Treatment Age in Days at Other Treatment Age of subject (in days) at their other treatment prior to a scan. C216944 Organism Attribute Age in Days at Other Treatment Prior to Scan CL1946105 Age in Days at Other Treatment Prior to Scan Age in Days at Other Treatment Prior to Scan Age of subject (in days) at their last radiation treatment prior to a scan. C216946 Organism Attribute Age in Days at Last Radiation Prior to Scan CL1946103 Age in Days at Last Radiation Prior to Scan Age in Days at Last Radiation Prior to Scan Age of subject (in days) at their last surgery prior to a scan. C216947 Organism Attribute Age in Days at Last Surgery Prior to Scan CL1946104 Age in Days at Last Surgery Prior to Scan Age in Days at Last Surgery Prior to Scan Age of subject (in days) at their first treatment. C216948 Organism Attribute Age in Days at Initial Treatment CL1946101 Age in Days at Initial Treatment Age in Days at Initial Treatment Age of subject (in days) at their first surgery. C216949 Organism Attribute Age in Days at Initial Surgery CL1946102 Age in Days at Initial Surgery Age in Days at Initial Surgery The age of a subject, in days, at the time of first surgery or procedure. C217244 Organism Attribute Age in Days at First Surgery or Procedure CL1946482 Age in Days at First Surgery or Procedure Age in Days at First Surgery or Procedure The age of a subject, in days, at the initial chemotherapy start date. C217245 Organism Attribute Age in Days at Initial Chemotherapy Start Date CL1946479 Age in Days at Initial Chemotherapy Start Date Age in Days at Initial Chemotherapy Start Date The age of a subject, in days, at the initial chemotherapy end date. C217246 Organism Attribute Age in Days at Initial Chemotherapy End Date CL1946480 Age in Days at Initial Chemotherapy End Date Age in Days at Initial Chemotherapy End Date The age of a subject, in days, at the initial radiation therapy start date. C217247 Organism Attribute Age in Days at Initial Radiation Therapy Start Date CL1946509 Age in Days at Initial Radiation Therapy Start Date Age in Days at Initial Radiation Therapy Start Date The age of a subject, in days, at the initial radiation therapy end date. C217248 Organism Attribute Age in Days at Initial Radiation Therapy End Date CL1946510 Age in Days at Initial Radiation Therapy End Date Age in Days at Initial Radiation Therapy End Date The age of a subject, in days, at the date when progression was first diagnosed. C217249 Organism Attribute Age in Days at Date of First Progression CL1946507 Age in Days at Date of First Progression Age in Days at Date of First Progression The age of a subject, in days, at the date when further progression was diagnosed. C217250 Organism Attribute Age in Days at Date of Further Progression CL1946508 Age in Days at Date of Further Progression Age in Days at Date of Further Progression The age of a subject, in days, at the date of new treatment. C217251 Organism Attribute Age in Days at Date of New Treatment CL1946505 Age in Days at Date of New Treatment Age in Days at Date of New Treatment The age of a subject, in days, at the date of the start of additional therapy. C217252 Organism Attribute Age in Days at Date of Additional Therapy Start CL1946506 Age in Days at Date of Additional Therapy Start Age in Days at Start Date of Additional Therapy Age in Days at Date of Additional Therapy Start The age of a subject, in days, at the date of the completion of additional therapy. C217253 Organism Attribute Age in Days at Date of Additional Therapy Complete CL1946503 Age in Days at Date of Additional Therapy Complete Age in Days at End Date of Additional Therapy Age in Days at Date of Additional Therapy Complete The age of a subject, in days, at the date of the start of the second additional therapy. C217254 Organism Attribute Age in Days at Date of Second Additional Therapy Start CL1946504 Age in Days at Date of Second Additional Therapy Start Age in Days at Start Date of Second Additional Therapy Age in Days at Date of Second Additional Therapy Start The age of a subject, in days, at the date of the completion of the second additional therapy. C217255 Organism Attribute Age in Days at Date of Second Additional Therapy Complete CL1946501 Age in Days at Date of Second Additional Therapy Complete Age in Days at End Date of Second Additional Therapy Age in Days at Date of Second Additional Therapy Complete The age of a subject, in days, at the date of the start of immunotherapy. C217256 Organism Attribute Age in Days at Date of Immunotherapy Start CL1946502 Age in Days at Date of Immunotherapy Start Age in Days at Start Date of Immunotherapy Age in Days at Date of Immunotherapy Start The age of a subject, in days, at the date of the completion of immunotherapy. C217257 Organism Attribute Age in Days at Date of Immunotherapy Complete CL1946499 Age in Days at Date of Immunotherapy Complete Age in Days at End Date of Immunotherapy Age in Days at Date of Immunotherapy Complete The age of a subject, in days, at the date of brachytherapy insertion. C217258 Organism Attribute Age in Days at Date of Brachytherapy Insertion CL1946500 Age in Days at Date of Brachytherapy Insertion Age in Days at Date of Brachytherapy Insertion The age of a subject, in days, at the date of the start of other additional therapy. C217259 Organism Attribute Age in Days at Date of Other Additional Therapy Start CL1946497 Age in Days at Date of Other Additional Therapy Start Age in Days at Start Date of Other Additional Therapy Age in Days at Date of Other Additional Therapy Start The age of a subject, in days, at the date of the completion of other additional therapy. C217260 Organism Attribute Age in Days at Date of Other Additional Therapy Complete CL1946498 Age in Days at Date of Other Additional Therapy Complete Age in Days at End Date of Other Additional Therapy Age in Days at Date of Other Additional Therapy Complete The age of a subject, in days, on the MRI date. C217261 Organism Attribute Age in Days at Date of MRI CL1946495 Age in Days at Date of MRI Age in Days at Date of Magnetic Resonance Imaging Age in Days at Date of MRI The age of a subject, in days, at the date of the first MRI. C217262 Organism Attribute Age in Days at Date of First MRI CL1946496 Age in Days at Date of 1st MRI Age in Days at Date of First MRI Age in Days at Date of First Magnetic Resonance Imaging Age in Days at Date of First MRI The age of a subject, in days, at the date of the second MRI. C217263 Organism Attribute Age in Days at Date of Second MRI CL1946525 Age in Days at Date of 2nd MRI Age in Days at Date of Second MRI Age in Days at Date of Second Magnetic Resonance Imaging Age in Days at Date of Second MRI The age of a subject, in days, at the date of the third MRI. C217264 Organism Attribute Age in Days at Date of Third MRI CL1946526 Age in Days at Date of 3rd MRI Age in Days at Date of Third MRI Age in Days at Date of Third Magnetic Resonance Imaging Age in Days at Date of Third MRI The age of a subject, in days, at the date of the fourth MRI. C217265 Organism Attribute Age in Days at Date of Fourth MRI CL1946523 Age in Days at Date of 4th MRI Age in Days at Date of Fourth MRI Age in Days at Date of Fourth Magnetic Resonance Imaging Age in Days at Date of Fourth MRI The age of a subject, in days, at the date of the fifth MRI. C217266 Organism Attribute Age in Days at Date of Fifth MRI CL1946524 Age in Days at Date of 5th MRI Age in Days at Date of Fifth MRI Age in Days at Date of Fifth Magnetic Resonance Imaging Age in Days at Date of Fifth MRI The age of a subject, in days, at the date of the sixth MRI. C217267 Organism Attribute Age in Days at Date of Sixth MRI CL1946521 Age in Days at Date of 6th MRI Age in Days at Date of Sixth MRI Age in Days at Date of Sixth Magnetic Resonance Imaging Age in Days at Date of Sixth MRI The age of a subject, in days, at the time of surgical resection. C217268 Organism Attribute Age in Days at Surgical Resection CL1946522 Age in Days at Surgical Resection Age in Days at Surgical Resection Age of subject (in days) at a biopsy procedure. C219058 Organism Attribute Age in Days at Biopsy CL1948657 Age in Days at Biopsy Age in Days at Biopsy Age of subject (in days) when a specimen was processed. C219629 Organism Attribute Age in Days to Specimen Processing CL1948934 Age in Days to Specimen Processing Age in Days to Specimen Processing Age of subject (in days) when a specimen tissue block was sectioned. C219630 Organism Attribute Age in Days at Specimen Tissue Block Sectioning CL1948935 Age in Days at Specimen Tissue Block Sectioning Age in Days at Specimen Tissue Block Sectioning Age of subject (in days) at their last treatment. C219631 Organism Attribute Age in Days at Last Treatment CL1948929 Age in Days at Last Treatment Age in Days at Last Treatment A person who is not a smoker at the current time. This includes both those who have never smoked and those who were former smokers. C219706 Organism Attribute Non-Smoker C0337672 Current Non-Smoker Non-Smoker Non-Smoker The age at which disease began or were first noted. C221539 Organism Attribute Age At Disease Onset CL1954176 CDISC The age at which disease began or were first noted. AGEDSONS Age At Disease Onset Age At Disease Onset The age of a subject, in days, at the time of surgery. C222646 Organism Attribute Age in Days at Surgical Procedure CL1955902 Age in Days at Surgery Age in Days at Surgical Procedure Age in Days at Surgical Procedure The age of a subject, in days, at the date when cancer was first diagnosed. C224137 Organism Attribute Age in Days at First Cancer Diagnosis Age in Days at First Cancer Diagnosis Age in Days at First Cancer Diagnosis How long something has existed; elapsed time since birth. C25150 Organism Attribute Age C0001779 BRIDG CDISC FDA INC NICHD How long something has existed; elapsed time since birth. (NCI) The time elapsed since birth. Time elapsed after birth. Age AGE Age Aged Chronological Age Postnatal Age age Age The state of being engaged in an activity or service for wages or salary. C25172 Functional Concept Employed C0014003 ACC/AHA CDISC The state of being engaged in an activity or service for wages or salary. The state of being engaged in an activity or services for wages or salary. Employment EMPLOYED Employed Employment Employed The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart. C25298 Quantitative Concept Systolic Blood Pressure C0871470 ACC/AHA CDISC ICDC PCDC Systolic blood pressure value recorded closest to the time of presentation to the health care facility The maximum blood pressure in the systemic arterial circulation during the cardiac cycle. Systolic_Pressure SYSBP Systolic Blood Pressure Systolic Pressure Systolic blood pressure systolic bp systolic_bp Systolic Blood Pressure The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling. C25299 Clinical Attribute Diastolic Blood Pressure C0428883 ACC/AHA CDISC PCDC Diastolic blood pressure value recorded closest to the time of presentation to the health care facility The minimum blood pressure in the systemic arterial circulation during the cardiac cycle. Diastolic_Pressure DIABP Diastolic Blood Pressure Diastolic Pressure Diastolic blood pressure Diastolic Blood Pressure The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension. C25347 Quantitative Concept Height C0489786 CDISC FDA The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension. (NCI) Vertical measurement value. Height HEIGHT Height Height A system, commonly called the INR, established by the World Health Organization (WHO) and the International Committee on Thrombosis and Hemostasis for reporting the results of blood coagulation (clotting) tests. All results are standardized using the international sensitivity index (ISI) for the particular thromboplastin reagent and instrument combination utilized to perform the test; the ratio of a patient's clotting time to the lab's mean reference value is normalized against the ISI. (from medterms.com and medicine.ucsf.edu) C25352 Quantitative Concept International Normalized Ratio CL448971 International_Normalized_Ratio INR International Normalized Ratio International Normalized Ratio A birth weight that is less than 2500 grams. C34724 Finding Low Birth Weight C4230930 GAIA NICHD Birth weight less than 2500 grams. Low_Birth_Weight Low Birth Weight Low Birth Weight The length of a person's life, stated in months since birth. C37907 Organism Attribute Age-Months C1510828 Age-Months Age, in Months Age-Months Age-Months The length of a person's life, stated in years since birth. C37908 Organism Attribute Age-Years C1510829 Age-Years Age, in Years Age-Years Age-Years A gain or recurrent benefit during a period of time, usually measured in money that derives from capital or labor. C41150 Group Attribute Income C0021162 Income Income is one of the major demographic parameters used in population-based biomedical research. Income Income Individuals with origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands, including, for example, Native Hawaiian, Samoan, Chamorro, Tongan, Fijian, and Marshallese. C41219 Population Group Native Hawaiian or Other Pacific Islander C1513907 CDISC CTDC FDA GDC OORO PCDC SeroNet Denotes a person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands. The term covers particularly people who identify themselves as part-Hawaiian, Native Hawaiian, Guamanian or Chamorro, Carolinian, Samoan, Chuu. (FDA) Native_Hawaiian_or_Other_Pacific_Islander native hawaiian or other pacific islander NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER NATIVE_HAWAIIAN_OR_OTHER_PACIFIC_ISLANDER Native Hawaiian or Other Pacific Islander Pacific Islander native hawaiian or other pacific islander Native Hawaiian or Other Pacific Islander A person not of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. C41222 Population Group Not Hispanic or Latino C1518424 CDISC CTDC FDA GDC OORO PCDC SeroNet A person not of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. An arbitrary ethnic classification. (NCI) Not_Hispanic_or_Latino not hispanic or latino NOT HISPANIC OR LATINO NOT_HISPANIC_OR_LATINO Non-Hispanic Non-Hispanic or Latino Not Hispanic or Latino Not Hispanic/Spanish origin not hispanic or latino Not Hispanic or Latino Denotes a person of African ancestral origins whose family settled in the Caribbean region. C41226 Population Group African Caribbean C0422771 CDISC A person having origins in the original peoples of sub-Saharan Africa and the Caribbean. African_Caribbean AFRICAN CARIBBEAN African Caribbean African Caribbean Ancestry African Caribbean Descent Afro-Caribbean African Caribbean Individuals with origins in any of the original peoples of North, Central, and South America, including, for example, Navajo Nation, Blackfeet Tribe of the Blackfeet Indian Reservation of Montana, Native Village of Marrow Inupiat Traditional Government, Nome Eskimo Community, Aztec, and Maya. C41259 Population Group American Indian or Alaska Native C0282204 CDISC CTDC DIPG/DMG FDA GDC OORO PCDC SeroNet A person having origins in any of the original peoples of North and South America (including Central America), and who maintains tribal affiliation or community attachment. (FDA) American_Indian_or_Alaska_Native american indian or alaska native AMERICAN INDIAN OR ALASKA NATIVE AMERICAN_INDIAN_OR_ALASKA_NATIVE American Indian or Alaska Native First Nations Indigenous American Native American Native Americans american indian or alaska native American Indian or Alaska Native Individuals with origins in any of the original peoples of Central or East Asia, Southeast Asia, or South Asia including, for example, Chinese, Asian Indian, Filipino, Vietnamese, Korean, and Japanese. C41260 Population Group Asian C0078988 CDISC CTDC DIPG/DMG FDA GDC OORO PCDC SeroNet A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent including, for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. (FDA) Asian asian ASIAN Asian Asian Ancestry Asians asian Asian Individuals with origins in any of the original peoples of Europe, including for example, English, German, Irish, Italian, Polish, and Scottish. C41261 Population Group White C0043157 CDISC CTDC DIPG/DMG FDA GDC OORO PCDC SeroNet Denotes a person with European, Middle Eastern, or North African ancestral origin who identifies, or is identified, as White. (FDA) White white Caucasian Caucasians Caucasoid Occidental WHITE White Whites white White A person having origins in the original peoples of the Indian sub-continent. C41262 Population Group Asian Indian C1524069 CDISC FDA A person having origins in any of the original peoples of the Indian subcontinent. Asian_Indian The concept is close to the term South Asian but several major South Asian populations such as Pakistani and Bangladeshi may not identify with it. ASIAN INDIAN Asian Indian Asian Indians Indian Asian Indian Denotes a person whose ancestry is in the countries of the Indian sub-continent, including India, Pakistan, Bangladesh, and Sri Lanka. C41263 Population Group South Asian C1519427 CDISC A person having origins in any of the original peoples of the South Asia. South_Asian SOUTH ASIAN South Asian South Asians South Asian Denotes a person with ancestral origins are in any of the countries of Africa. C42331 Population Group African C0027567 CDISC A person having origins in any of the original peoples of Africa. African AFRICAN African African Ancestry African Descent African A person having origins in the original Aleutian people. C43389 Population Group Aleutian C1553304 Aleutian Aleutian Aleutian The native people inhabiting the Arctic of northern Canada, Greenland, Alaska, or eastern Siberia. The two main groups referred to as Eskimo are the Yupik and Inuit. A third group, the Aleut, is related. In Canada and Greenland, the term Eskimo has fallen out of favor, as it is considered pejorative by the natives and has been replaced by the term Inuit. C43390 Population Group Eskimo C0014845 Eskimo Eskimo Inuit Eskimo A person having origins in any of the original peoples of China. C43391 Population Group Chinese C0152035 CDISC FDA A person having origins in any of the original peoples of China. Chinese CHINESE Chinese Chinese A person having origins in any of the original peoples of Japan.. C43392 Population Group Japanese C1556094 CDISC FDA A person having origins in any of the original peoples of Japan. Japanese JAPANESE Japanese Japanese A person having origins in any of the original peoples of the Philippine Islands. C43393 Population Group Filipino C1556093 CDISC FDA A person having origins in any of the original peoples of the Philippines. Filipino FILIPINO Filipino Filipino A person having origins in any of the original peoples of Hawaii. C43394 Population Group Native Hawaiian C0337920 CDISC FDA A person having origins in any of the original peoples of Hawaii. (NCI) Hawaiian Hawaiian NATIVE HAWAIIAN Native Hawaiian Native Hawaiian A person having origins in any of the original peoples of Korea. C43395 Population Group Korean C1556095 CDISC A person having origins in any of the original peoples of North and South Korea. Korean KOREAN Korean Korean A person having origins in any of the original peoples of Viet Nam. C43396 Population Group Vietnamese C1561452 CDISC FDA A person having origins in any of the original peoples of Viet Nam. Vietnamese VIETNAMESE Vietnamese Vietnamese Denotes the inhabitants of Laos, a person from there, or their descendants elsewhere. C43397 Population Group Laotian C1553325 CDISC A person having origins in any of the original peoples of Laos. Laotian LAOTIAN Laotian Laotian Denotes a person having origins in any of the original Hmong people originating in China around the Yellow River or Hoang Ho. C43398 Population Group Hmong C1553324 CDISC The native people originating in China around the Yellow River or Hoang Ho. Hmong Early in the 19th century, the Hmong migrated to French Indochina, which comprised Vietnam, Cambodia and Laos. In 1947, Hmong officially became citizens of Loas. Later a number of Hmong emigrated to Thailand and the United States. HMONG Hmong Hmong Denotes the inhabitants of Cambodia (formerly Kampuchea), a person from there, or their descendants elsewhere. C43399 Population Group Cambodian C1553323 CDISC A person having origins in any of the original peoples of Cambodia (formerly Kampuchea). Kampuchean CAMBODIAN Cambodian Kampuchean Cambodian Denotes the inhabitants of Thailand, a person from there, or their descendants elsewhere. C43400 Population Group Thai C0337910 CDISC A person having origins in any of the original peoples of Thailand. Thai THAI Thai Thai Denotes a person from any of the islands in the western pacific encompassing the area from the Philippines in the west, Indonesia to the south west, Papua New Guinea and Melanesia to the south, and Polynesia to the south-east and east. C43402 Population Group Micronesian C1556099 CDISC A person having origins in any of the original peoples of Micronesia. Micronesian MICRONESIAN Micronesian Micronesian Denotes any of the indigenous Chamorro people of Guam and the Mariana Islands or persons of that ancestry. C43403 Population Group Chamorran C1553343 CDISC The native people of the Mariana Islands, including the United States territories of Guam and the Commonwealth of the Northern Mariana Islands in Micronesia. Chamorran CHAMORRO Chamorran Chamorro Chamorran Denotes the inhabitants of Guam, a person from there, or their descendants elsewhere. C43404 Population Group Guamanian C0920541 CDISC A person having origins in any of the original peoples of Guam. Guamanian GUAMANIAN Guamanian Guamanian Denotes a person from any of the over 1,000 islands in the central and southern Pacific Ocean bounded by a triangle with its three corners at Hawaii, New Zealand, and Easter Island or a person of that ancestry. C43405 Population Group Polynesian C0240790 CDISC A person having origins in any of the original peoples of Polynesia. Polynesian POLYNESIAN Polynesian Polynesian Denotes the inhabitants of Tahiti, a person from there, or their descendants elsewhere. C43406 Population Group Tahitian C0241329 CDISC A person having origins in any of the original peoples of Tahiti. Tahitian TAHITIAN Tahitian Tahitian A person having origins in any of the original peoples of Samoa. C43407 Population Group Samoan C1556103 CDISC FDA A person having origins in any of the original peoples of Samoa. (NCI) Samoan SAMOAN Samoan Samoan Denotes the inhabitants of Tonga, a person from there, or their descendants elsewhere. C43408 Population Group Tongan C1556108 CDISC A person having origins in any of the original peoples of Tonga. Tongan TONGAN Tongan Tongan Denotes a person from any of the islands in the region extending from the west Pacific to the Arafura Sea, north and north-east of Australia. or of that ancestry. C43409 Population Group Melanesian C0337924 CDISC A person having origins in any of the original peoples of Melanesia. Melanesian MELANESIAN Melanesian Melanesian Denotes the inhabitants of Fiji, a person from there, or their descendants elsewhere. C43410 Population Group Fiji Islander C1556097 CDISC A person having origins in any of the original peoples of Fiji. Fiji_Islander FIJIAN Fiji Islander Fijian Fiji Islander Denotes the inhabitants of Papua New Guinea, a person from there, or their descendants elsewhere. C43411 Population Group Papua New Guinean C1553350 New_Guinean New Guinean Papua New Guinean Papua New Guinean Primarily refers to a person having origins in the original peoples of the Indian sub-continent, a subset of which formed Pakistan. The term also refers to a person from Pakistan, whether or not ancestors were from India. C43427 Population Group Pakistani C0240620 CDISC A person having origins in any of the original peoples of Pakistan. Pakistani PAKISTANI Pakistani Pakistani A person having origins in the original Alaska Indian people. C43650 Population Group Alaska Indian CL333681 Alaska_Indian Alaska Indian Alaska Indian Denotes the inhabitants of Bangladesh, a person from there, or their descendants elsewhere. C43671 Population Group Bangladeshi C1556107 CDISC A person having origins in any of the original peoples of Bangladesh. Bangladeshi BANGLADESHI Bangladeshi Bangladeshi Denotes the inhabitants of Sri Lanka, a person from there, or their descendants elsewhere. C43672 Population Group Sri Lankan C1553327 CDISC A person having origins in any of the original peoples of Sri Lanka. Sri_Lankan SRI LANKAN Sri Lankan Sri Lankan Denotes the inhabitants of Bhutan, a person from there, or their descendants elsewhere. C43673 Population Group Bhutanese C0337894 CDISC A person having origins in any of the original peoples of Bhutan. Bhutanese BHUTANESE Bhutanese Bhutanese Denotes the inhabitants of Myanmar (formerly Burma), a person from there, or their descendants elsewhere. C43674 Population Group Burmese C1553322 CDISC A person having origins in any of the original peoples of Myanmar (formerly Burma). Burmese BURMESE Burmese Burmese Denotes the inhabitants of Taiwan, a person from there, or their descendants elsewhere. C43675 Population Group Taiwanese C1556096 CDISC A person having origins in any of the original peoples of Taiwan. Taiwanese TAIWANESE Taiwanese Taiwanese Denotes the inhabitants of Indonesia, a person from there, or their descendants elsewhere. C43715 Population Group Indonesian C0337900 CDISC A person having origins in any of the original peoples of Indonesia. Indonesian INDONESIAN Indonesian Indonesian Denotes the inhabitants of Malaysia, a person from there, or their descendants elsewhere. C43716 Population Group Malaysian C0240293 CDISC A person having origins in any of the original peoples of Malaysia. Malaysian MALAYSIAN Malaysian Malaysian Denotes the inhabitants of the japanese island of Okinawa, a person from there, or their descendants elsewhere. C43717 Population Group Okinawan C1553326 CDISC A person having origins in any of the original peoples of Okinawa. Okinawan OKINAWAN Okinawan Okinawan Denotes the inhabitants of Iwo Jima, a person from there, or their descendants elsewhere. C43718 Population Group Iwo Jiman C1553328 CDISC A person having origins in any of the original peoples of Iwo Jima. Iwo_Jiman IWO JIMAN Iwo Jiman Iwo Jiman Denotes the inhabitants of the Maldives, a person from there, or their descendants elsewhere. C43719 Population Group Maldivian C1553329 CDISC A person having origins in any of the original peoples of the Maldives. Maldivian MALDIVIAN Maldivian Maldivian Denotes the inhabitants of Nepal, a person from there, or their descendants elsewhere. C43720 Population Group Nepalese C1553330 CDISC A person having origins in any of the original peoples of Nepal. Nepalese NEPALESE Nepalese Nepalese Denotes the inhabitants of Singapore, a person from there, or their descendants elsewhere. C43721 Population Group Singaporean C1553331 CDISC A person having origins in any of the original peoples of Singapore. Singaporean SINGAPOREAN Singaporean Singaporean Denotes the inhabitants of Madagascar, a person from there, or their descendants elsewhere. C43722 Population Group Malagasy C1553332 CDISC A person having origins in any of the original peoples of Madagascar. Madagascar_Race MALAGASY Madagascar Malagasy Malagasy Denotes the inhabitants of Barbados, a person from there, or their descendants elsewhere. C43823 Population Group Barbadian C1553337 CDISC A person having origins in any of the original peoples of Barbados. Barbadian BARBADIAN Barbadian Barbadian Denotes the inhabitants of Dominica, a person from there, or their descendants elsewhere. C43824 Population Group Dominica Islander C1553338 CDISC A person having origins in any of the original peoples of Dominica. Dominican DOMINICA ISLANDER Dominica Islander Dominican Dominica Islander Denotes the inhabitants of Haiti, a person from there, or their descendants elsewhere. C43825 Population Group Haitian C0239806 CDISC A person having origins in any of the original peoples of Haiti. Haitian HAITIAN Haitian Haitian Denotes the inhabitants of Jamaica, a person from there, or their descendants elsewhere. C43826 Population Group Jamaican C0240072 CDISC A person having origins in any of the original peoples of Jamaica. Jamaican JAMAICAN Jamaican Jamaican Denotes the inhabitants of Tobago, a person from there, or their descendants elsewhere. C43827 Population Group Tobagoan C1553339 CDISC A person having origins in any of the original peoples of Tobago. Tobagoan TOBAGOAN Tabagonian Tobagoan Tobagoan Denotes the inhabitants of Trinidad, a person from there, or their descendants elsewhere. C43828 Population Group Trinidadian C1553340 CDISC A person having origins in any of the original peoples of Trinidad. Trinidadian TRINIDADIAN Trinidadian Trinidadian Denotes the inhabitants of the West Indies, a person from there, or their descendants elsewhere. C43829 Population Group West Indian C0425373 CDISC A person having origins in any of the original peoples of the West Indies. West_Indian WEST INDIAN West Indian West Indian Denotes the inhabitants of Botswana, a person from there, or their descendants elsewhere. C43830 Population Group Botswanan C1553333 CDISC A person having origins in any of the original peoples of Botswana. Botswanan BOTSWANAN Botswanan Motswana Botswanan Denotes the inhabitants of Ethiopia, a person from there, or their descendants elsewhere. C43831 Population Group Ethiopian C0239304 CDISC A person having origins in any of the original peoples of Ethiopia. Ethiopian ETHIOPIAN Ethiopian Ethiopian Denotes the inhabitants of Liberia, a person from there, or their descendants elsewhere. C43832 Population Group Liberian C1556088 CDISC A person having origins in any of the original peoples of Liberia. Liberian LIBERIAN Liberian Liberian Denotes the inhabitants of Namibia, a person from there, or their descendants elsewhere. C43833 Population Group Namibian C1553334 CDISC A person having origins in any of the original peoples of Namibia. Namibian NAMIBIAN Namibian Namibian Denotes the inhabitants of Nigeria, a person from there, or their descendants elsewhere. C43834 Population Group Nigerian C1556089 CDISC A person having origins in any of the original peoples of Nigeria. Nigerian NIGERIAN Nigerian Nigerian Denotes the inhabitants of the Democratic Republic of the Congo (formerly Zaire), a person from there, or their descendants elsewhere. C43835 Population Group Zairean C1553335 CDISC A person having origins in any of the original peoples of Zaire. Zairean ZAIREAN Zairean Zairean Denotes the inhabitants of Tokelau, a person from there, or their descendants elsewhere. C43836 Population Group Tokelauan C0438967 Tokelauan Tokelauan Tokelauan A person having origins in any of the original peoples of Guam or the Mariana Islands. C43837 Population Group Guamanian or Chamorro C1553342 CDISC FDA A person having origins in the original peoples of the United States territories of Guam and the Commonwealth of the Northern Mariana Islands in Micronesia. Guamanian_or_Chamorro GUAMANIAN OR CHAMORRO Guamanian or Chamorro Guamanian or Chamorro Denotes the inhabitants of the Northern Mariana Islands, a person from there, or their descendants elsewhere. C43838 Population Group Mariana Islander C1553344 Mariana_Islander Mariana Islander Mariana Islander Denotes the inhabitants of the Marshall Islands, a person from there, or their descendants elsewhere. C43839 Population Group Marshallese C1556098 CDISC A person having origins in any of the original peoples of the Marshall Islands. Marshallese MARSHALLESE Marshallese Marshallese Denotes the inhabitants of Palau, a person from there, or their descendants elsewhere. C43840 Population Group Palauan C0337928 CDISC A person having origins in any of the original peoples of Palau. Palauan PALAUAN Palauan Palauan Denotes the inhabitants of the Caroline Islands, a person from there, or their descendants elsewhere. C43841 Population Group Carolinian C1553345 Carolinian Carolinian Carolinian Denotes the inhabitants of the island of Kosrae, a person from there, or their descendants elsewhere. C43842 Population Group Kosraean C1553346 Kosraean Kosraean Kosraean Denotes the inhabitants of the island of Pohnpei, a person from there, or their descendants elsewhere. C43843 Population Group Pohnpeian C1553347 Pohnpeian Pohnpeian Pohnpeian Denotes the inhabitants of the Saipan Islands, a person from there, or their descendants elsewhere. C43844 Population Group Saipanese C1556102 Saipanese Saipanese Saipanese Denotes the inhabitants of Kiribati, a person from there, or their descendants elsewhere. C43845 Population Group Kiribati C1553348 Kiribati_Race Kiribati Kiribati Denotes the inhabitants of the island of Chuuk, a person from there, or their descendants elsewhere. C43846 Population Group Chuukese C1553349 CDISC The native peoples of the Chuuk State in the Federated States of Micronesia. Chuukese CHUUKESE Chuukese Chuukese Denotes the inhabitants of the island of Yap, a person from there, or their descendants elsewhere. C43847 Population Group Yapese C1556105 Yapese Yapese Yapese Denotes the inhabitants of the Solomon Islands, a person from there, or their descendants elsewhere. C43849 Population Group Solomon Islander C0337932 Solomon_Islander Solomon Islander Solomon Islander Denotes the inhabitants of the islands of Vanuatu, a person from there, or their descendants elsewhere. C43850 Population Group New Hebrides C1571857 New_Hebrides New Hebrides New Hebrides Denotes the inhabitants of any of the countries of Europe, a person from there, or their descendants elsewhere. C43851 Population Group European C1535514 CDISC A person having origins in any of the original peoples of Europe. European EUROPEAN European European Denotes the inhabitants of Armenia, a person from there, or their descendants elsewhere. C43852 Population Group Armenian C0337794 Armenian Armenian Armenian Denotes the inhabitants of England, a person from there, or their descendants elsewhere. C43853 Population Group English C1556083 CDISC A person having origins in any of the original peoples of England. English ENGLISH English English Denotes the inhabitants of France, a person from there, or their descendants elsewhere. C43854 Population Group French C1556084 CDISC A person having origins in any of the original peoples of France. French FRENCH French French Denotes the inhabitants of Germany, a person from there, or their descendants elsewhere. C43855 Population Group German C1556085 CDISC A person having origins in any of the original peoples of Germany. German GERMAN German German Denotes the inhabitants of Ireland, a person from there, or their descendants elsewhere. C43856 Population Group Irish C0087186 CDISC A person having origins in any of the original peoples of Ireland. Irish IRISH Irish Irish Denotes the inhabitants of Italy, a person from there, or their descendants elsewhere. C43857 Population Group Italian C0337810 CDISC A person having origins in any of the original peoples of Italy. Italian ITALIAN Italian Italian Denotes the inhabitants of Poland, a person from there, or their descendants elsewhere. C43858 Population Group Polish C0220896 CDISC A person having origins in any of the original peoples of Poland. Polish POLISH Polish Polish Denotes the inhabitants of Scotland, a person from there, or their descendants elsewhere. C43859 Population Group Scottish C0240966 CDISC A person having origins in any of the original peoples of Scotland. Scottish SCOTTISH Scottish Scottish Denotes the inhabitants of Russia, a person from there, or their descendants elsewhere. C43860 Population Group Russian C0337816 CDISC A person having origins in any of the original peoples of Russia. Russian RUSSIAN Russian Russian Denotes the inhabitants of Sweden, a person from there, or their descendants elsewhere. C43861 Population Group Swedish C1710263 CDISC A person having origins in any of the original peoples of Sweden. Swedish SWEDISH Swedish Swedish Denotes the inhabitants of Norway, a person from there, or their descendants elsewhere. C43862 Population Group Norwegian C0337812 CDISC A person having origins in any of the original peoples of Norway. Norwegian NORWEGIAN Norwegian Norwegian Denotes the inhabitants of Ukraine, a person from there, or their descendants elsewhere. C43863 Population Group Ukrainian C1710525 Ukranian Ukrainian Ukrainian Denotes the inhabitants of Mongolia, a person from there, or their descendants elsewhere. C43864 Population Group Mongolian C1709065 CDISC A person having origins in any of the original peoples of Mongolia. Mongolian MONGOLIAN Mongolian Mongolian Denotes the inhabitants of Finland, a person from there, or their descendants elsewhere. C43865 Population Group Finnish C1711254 Finnish Finnish Finnish Individuals with origins in any of the original peoples of the Middle East or North Africa, including, for example, Lebanese, Iranian, Egyptian, Syrian, Iraqi, and Israeli. C43866 Population Group Middle Eastern or North African C1553353 Middle_Eastern_or_North_African Middle Eastern or North African Middle Eastern or North African A collective term used to identify indigenous peoples of northern Iraq and neighboring areas of Syria and Turkey, who also identify themselves as Aramaeans and Chaldeans. They are the survivors of the formerly extensive Aramaic- or Syriac- speaking Christian community of northern Iraq, southeastern Turkey, and northwestern Iran. C43867 Population Group Assyrian C1553354 Assyrian Assyrian Assyrian Denotes the inhabitants of Egypt, a person from there, or their descendants elsewhere. C43868 Population Group Egyptian C0337801 CDISC A person having origins in any of the original peoples of Egypt. Egyptian EGYPTIAN Egyptian Egyptian Denotes the inhabitants of Iran, a person from there, or their descendants elsewhere. C43869 Population Group Iranian C1553355 CDISC A person having origins in any of the original peoples of Iran. Iranian IRANIAN Iranian Iranian Denotes the inhabitants of Iraq, a person from there, or their descendants elsewhere. C43870 Population Group Iraqi C1556087 CDISC A person having origins in any of the original peoples of Iraq. Iraqi IRAQI Iraqi Iraqi Denotes the inhabitants of Lebanon, a person from there, or their descendants elsewhere. C43871 Population Group Lebanese C1553356 CDISC A person having origins in any of the original peoples of Lebanon. Lebanese LEBANESE Lebanese Lebanese Denotes those persons of mainly Arabic speakers who regard themselves as a distinct branch of the Arabic-speaking peoples, with family origin in Palestine being the defining characteristic. C43872 Population Group Palestinian C0282539 Palestinian Palestinian Palestinian Denotes the inhabitants of Syria, a person from there, or their descendants elsewhere. C43873 Population Group Syrian C0337819 CDISC A person having origins in any of the original peoples of Syria. Syrian SYRIAN Syrian Syrian Denotes the inhabitants of Afghanistan, a person from there, or their descendants elsewhere. C43874 Population Group Afghanistani C1553357 CDISC A person having origins in any of the original peoples of Afghanistan. Afghanistani AFGHAN Afghan Afghanistani Afghanistani Denotes the inhabitants of Israel, a person from there, or their descendants elsewhere. C43875 Population Group Israeli C0240069 CDISC A person having origins in any of the original peoples of Israel. Israeli ISRAELI Israeli Israeli Denotes a person with ethnic origins in the Semitic people originally from the Arabian peninsula and surrounding territories in the Middle East and northern Africa. C43876 Population Group Arab C0282540 CDISC A person having origins in any of the original peoples of the Arabian peninsula and surrounding territories in the Middle East and northern Africa. Arab ARAB Arab Arab Denotes a person having origins in one of the indigenous peoples of North, Central, or South America, who lived in these lands prior to the European colonization. C43877 Population Group American Indian C0002460 CDISC The native people of North America. American_Indian AMERICAN INDIAN American Indian American Indian A person having origins in the original Abenaki people. C43878 Population Group Abenaki C1555038 Abenaki Abenaki Abenaki A person having origins in the original Algonquian people. C43879 Population Group Algonquian C1555039 Algonquian Algonquian Algonquian A person having origins in the original Apache people. C43880 Population Group Apache C0337855 Apache Apache Apache A person having origins in the original Chiricahua people. C43881 Population Group Chiricahua C1555040 Chiricahua Chiricahua Chiricahua Apache Chiricahua A person having origins in the original Fort Sill Apache people. C43882 Population Group Fort Sill Apache C1555041 Fort_Sill_Apache Fort Sill Apache Fort Sill Apache A person having origins in the original Jicarilla Apache people. C43883 Population Group Jicarilla Apache C1555042 Jicarilla_Apache Jicarilla Apache Jicarilla Apache A person having origins in the original Lipan Apache people. C43884 Population Group Lipan Apache C1555043 Lipan_Apache Lipan Apache Lipan Apache A person having origins in the original Mescalero Apache people. C43885 Population Group Mescalero Apache C1555044 Mescalero_Apache Mescalero Apache Mescalero Apache A person having origins in the original Oklahoma Apache people. C43886 Population Group Oklahoma Apache C1555045 Oklahoma_Apache Oklahoma Apache Oklahoma Apache A person having origins in the original Payson Apache people. C43887 Population Group Payson Apache C1555046 Payson_Apache Payson Apache Payson Apache A person having origins in the original San Carlos Apache people. C43888 Population Group San Carlos Apache C1555047 San_Carlos_Apache San Carlos Apache San Carlos Apache A person having origins in the original White Mountain Apache people. C43889 Population Group White Mountain Apache C1555048 White_Mountain_Apache White Mountain Apache White Mountain Apache A person having origins in the original Arapaho people. C43890 Population Group Arapaho C0682104 Arapaho Arapaho Arapaho A person having origins in the original Northern Arapaho people. C43891 Population Group Northern Arapaho C1555049 Northern_Arapaho Northern Arapaho Northern Arapaho A person having origins in the original Southern Arapaho people. C43892 Population Group Southern Arapaho C1555050 Southern_Arapaho Southern Arapaho Southern Arapaho A person having origins in the original Wind River Arapaho people. C43893 Population Group Wind River Arapaho C1555051 Wind_River_Arapaho Wind River Arapaho Wind River Arapaho A person having origins in the original Arikara people. C43894 Population Group Arikara C1555052 Arikara Arikara Arikara A person having origins in the original Assiniboine people. C43895 Population Group Assiniboine C1555053 Assiniboine Assiniboine Assiniboine A person having origins in the original Assiniboine Sioux people. C43896 Population Group Assiniboine Sioux C1555054 Assiniboine_Sioux Assiniboine Sioux Assiniboine Sioux A person having origins in the original Fort Peck Assiniboine Sioux people. C43897 Population Group Fort Peck Assiniboine Sioux C1555055 Fort_Peck_Assiniboine_Sioux Fort Peck Assiniboine Sioux Fort Peck Assiniboine Sioux A person having origins in the original Bannock people. C43898 Population Group Bannock C1555056 Bannock Bannock Bannock A person having origins in the original Blackfeet people. C43899 Population Group Blackfeet C0337860 Blackfeet Blackfeet Blackfeet A person having origins in the original Brotherton people. C43900 Population Group Brotherton C1555057 Brotherton Brotherton Brotherton A person having origins in the original Burt Lake Band people. C43901 Population Group Burt Lake Band C1555058 Burt_Lake_Band Burt Lake Band Burt Lake Band A person having origins in the original Caddo people. C43902 Population Group Caddo C1555059 Caddo Caddo Caddo A person having origins in the original Oklahoma Cado people. C43903 Population Group Oklahoma Cado C1555060 Oklahoma_Cado Oklahoma Cado Oklahoma Cado A person having origins in the original Cahuilla people. C43904 Population Group Cahuilla C1555061 Cahuilla Cahuilla Cahuilla A person having origins in the original Agua Caliente Cahuilla people. C43905 Population Group Agua Caliente Cahuilla C1555062 Agua_Caliente_Cahuilla Agua Caliente Cahuilla Agua Caliente Cahuilla A person having origins in the original Augustine people. C43909 Population Group Augustine C1555063 Augustine Augustine Augustine A person having origins in the original Cabazon people. C43910 Population Group Cabazon C1555064 Cabazon Cabazon Cabazon A person having origins in the original Los Coyotes people. C43911 Population Group Los Coyotes C1555065 Los_Coyotes Los Coyotes Los Coyotes A person having origins in the original Morongo people. C43912 Population Group Morongo C1555066 Morongo Morongo Morongo A person having origins in the original Santa Rosa Cahuilla people. C43913 Population Group Santa Rosa Cahuilla C1555067 Santa_Rosa_Cahuilla Santa Rosa Cahuilla Santa Rosa Cahuilla A person having origins in the original Torres-Martinez people. C43914 Population Group Torres-Martinez C1555068 Torres_Martinez Torres-Martinez Torres-Martinez A person having origins in the original California Tribes people. C43915 Population Group California Tribes C1555069 California_Tribes California Tribes California Tribes A person having origins in the original Canadian and Latin American Indian people. C43916 Population Group Canadian and Latin American Indian C1555083 Canadian_and_Latin_American_Indian Canadian and Latin American Indian Canadian and Latin American Indian A person having origins in the original Catawba people. C43917 Population Group Catawba C0682102 Catawba Catawba Catawba A person having origins in the original Cayuse people. C43918 Population Group Cayuse C1555088 Cayuse Cayuse Cayuse A person having origins in the original Chehalis people. C43919 Population Group Chehalis C1555089 Chehalis Chehalis Chehalis A person having origins in the original Chemakuan people. C43920 Population Group Chemakuan C1555090 Chemakuan Chemakuan Chemakuan A person having origins in the original Hoh people. C43921 Population Group Hoh C1555091 Hoh Hoh Hoh A person having origins in the original Quileute people. C43922 Population Group Quileute C1555092 Quileute Quileute Quileute A person having origins in the original Chemehuevi people. C43923 Population Group Chemehuevi C1555093 Chemehuevi Chemehuevi Chemehuevi A person having origins in the original Cherokee people. C43924 Population Group Cherokee C0682103 Cherokee Cherokee Cherokee A person having origins in the original Cherokee Shawnee people. C43925 Population Group Cherokee Shawnee C1555104 Cherokee_Shawnee Cherokee Shawnee Cherokee Shawnee A person having origins in the original Cheyenne people. C43926 Population Group Cheyenne C0682106 Cheyenne Cheyenne Cheyenne A person having origins in the original Northern Cheyenne people. C43927 Population Group Northern Cheyenne C1555105 Northern_Cheyenne Northern Cheyenne Northern Cheyenne A person having origins in the original Southern Cheyenne people. C43928 Population Group Southern Cheyenne C1555106 Southern_Cheyenne Southern Cheyenne Southern Cheyenne A person having origins in the original Cheyenne-Arapaho people. C43929 Population Group Cheyenne-Arapaho C1555107 Cheyenne_Arapaho Cheyenne-Arapaho Cheyenne-Arapaho A person having origins in the original Chickahominy people. C43930 Population Group Chickahominy C1555108 Chickahominy Chickahominy Chickahominy A person having origins in the original Eastern Chickahominy people. C43931 Population Group Eastern Chickahominy C1555109 Eastern_Chickahominy Eastern Chickahominy Eastern Chickahominy A person having origins in the original Western Chickahominy people. C43932 Population Group Western Chickahominy C1555110 Western_Chickahominy Western Chickahominy Western Chickahominy A person having origins in the original Chickasaw people. C43933 Population Group Chickasaw C0682101 Chickasaw Chickasaw Chickasaw A person having origins in the original Chinook Indians people. C43934 Population Group Chinook Indians C1555111 Chinook Chinook Chinook Indians Chinook Indians A person having origins in the original Chippewa people. C43935 Population Group Chippewa C0337862 Chippewa Chippewa Chippewa A person having origins in the original Chippewa Cree people. C43936 Population Group Chippewa Cree C1555144 Chippewa_Cree Chippewa Cree Chippewa Cree A person having origins in the original Rocky Boy's Chippewa Cree people. C43937 Population Group Rocky Boy's Chippewa Cree C1555145 Rocky_Boy_s_Chippewa_Cree Rocky Boy's Chippewa Cree Rocky Boy's Chippewa Cree A person having origins in the original Chitimacha people. C43938 Population Group Chitimacha C1555146 Chitimacha Chitimacha Chitimacha A person having origins in the original Choctaw people. C43939 Population Group Choctaw C0682100 Choctaw Choctaw Choctaw A person having origins in the original Clifton Choctaw people. C43940 Population Group Clifton Choctaw C1555147 Clifton_Choctaw Clifton Choctaw Clifton Choctaw A person having origins in the original Jena Choctaw people. C43941 Population Group Jena Choctaw C1555148 Jena_Choctaw Jena Choctaw Jena Choctaw A person having origins in the original Mississippi Choctaw people. C43942 Population Group Mississippi Choctaw C1555149 Mississippi_Choctaw Mississippi Choctaw Mississippi Choctaw A person having origins in the original Mowa Band of Choctaw people. C43943 Population Group Mowa Band of Choctaw C1555150 Mowa_Band_of_Choctaw Mowa Band of Choctaw Mowa Band of Choctaw A person having origins in the original Oklahoma Choctaw people. C43944 Population Group Oklahoma Choctaw C1555151 Oklahoma_Choctaw Oklahoma Choctaw Oklahoma Choctaw A person having origins in the original Chumash people. C43945 Population Group Chumash C0682116 Chumash Chumash Chumash A person having origins in the original Santa Ynez people. C43946 Population Group Santa Ynez C1555152 Santa_Ynez Santa Ynez Santa Ynez A person having origins in the original Clear Lake people. C43947 Population Group Clear Lake C1555153 Clear_Lake Clear Lake Clear Lake A person having origins in the original Coeur D'Alene people. C43948 Population Group Coeur D'Alene C1555154 Coeur_D_Alene Coeur D'Alene Coeur D'Alene A person having origins in the original Coharie people. C43949 Population Group Coharie C1555155 Coharie Coharie Coharie A person having origins in the original Colorado River people. C43950 Population Group Colorado River C1555156 Colorado_River Colorado River Colorado River A person having origins in the original Colville people. C43951 Population Group Colville C1555157 Colville Colville Colville A person having origins in the original Comanche people. C43952 Population Group Comanche C0682105 Comanche Comanche Comanche A person having origins in the original Oklahoma Comanche people. C43953 Population Group Oklahoma Comanche C1555158 Oklahoma_Comanche Oklahoma Comanche Oklahoma Comanche A person having origins in the original Coos, Lower Umpqua, Siuslaw people. C43954 Population Group Coos, Lower Umpqua, Siuslaw C1555159 Coos_Lower_Umpqua_Siuslaw Coos Lower Umpqua Siuslaw Coos, Lower Umpqua, Siuslaw Coos, Lower Umpqua, Siuslaw A person having origins in the original Coos people. C43955 Population Group Coos C1555160 Coos Coos Coos A person having origins in the original Coquilles people. C43956 Population Group Coquilles C1555161 Coquilles Coquilles Coquilles A person having origins in the original Costanoan people. C43957 Population Group Costanoan C1555162 Costanoan Costanoan Costanoan A person having origins in the original Coushatta people. C43958 Population Group Coushatta C0337865 Coushatta Coushatta Coushatta A person having origins in the original Alabama Coushatta people. C43959 Population Group Alabama Coushatta C1555163 Alabama_Coushatta Alabama Coushatta Alabama Coushatta A person having origins in the original Cowlitz people. C43961 Population Group Cowlitz C1555164 Cowlitz Cowlitz Cowlitz A person having origins in the original Cree people. C43962 Population Group Cree C0702268 Cree Cree Cree A person having origins in the original Creek people. C43963 Population Group Creek C1555165 Creek Creek Creek A person having origins in the original Croatan people. C43964 Population Group Croatan C1555178 Croatan Croatan Croatan A person having origins in the original Crow people. C43965 Population Group Crow C1555179 Crow Crow Crow A person having origins in the original Cupeno people. C43967 Population Group Cupeno C1555180 Cupeno Cupeno Cupeno A person having origins in the original Agua Caliente people. C43968 Population Group Agua Caliente C1555181 Agua_Caliente Agua Caliente Agua Caliente A person having origins in the original Diegueno people. C43970 Population Group Diegueno C0337867 Diegueno Diegueno Diegueño Kumeyaay Diegueno A person having origins in the original Eastern Tribes people. C43971 Population Group Eastern Tribes C1555198 Eastern_Tribes Eastern Tribes Eastern Tribes A person having origins in the original Esselen people. C43972 Population Group Esselen C1555214 Esselen Esselen Esselen A person having origins in the original Fort Belknap people. C43973 Population Group Fort Belknap C1555215 Fort_Belknap Fort Belknap Fort Belknap A person having origins in the original Fort Berthold people. C43974 Population Group Fort Berthold C1555216 Fort_Berthold Fort Berthold Fort Berthold A person having origins in the original Fort McDowell people. C43975 Population Group Fort McDowell C1555217 Fort_McDowell Fort McDowell Fort Mcdowell Fort McDowell A person having origins in the original Fort Hall people. C43976 Population Group Fort Hall C1555218 Fort_Hall Fort Hall Fort Hall A person having origins in the original Gabrieleno people. C43977 Population Group Gabrieleno C1555219 Gabrieleno Gabrieleno Gabrieleno A person having origins in the original Grand Ronde people. C43978 Population Group Grand Ronde C1555220 Grand_Ronde Grand Ronde Grand Ronde A person having origins in the original Gros Ventres people. C43979 Population Group Gros Ventres C1555221 Gros_Ventres Gros Ventres Gros Ventres A person having origins in the original Atsina people. C43980 Population Group Atsina C1555222 Atsina Atsina Atsina A person having origins in the original Haliwa people. C43981 Population Group Haliwa C1555223 Haliwa Haliwa Haliwa A person having origins in the original Hidatsa people. C43982 Population Group Hidatsa C1555224 Hidatsa Hidatsa Hidatsa A person having origins in the original Hoopa people. C43983 Population Group Hoopa C1555225 Hoopa Hoopa Hoopa A person having origins in the original Trinity people. C43984 Population Group Trinity C1555226 Trinity Trinity Trinity A person having origins in the original Whilkut people. C43985 Population Group Whilkut C1555227 Whilkut Whilkut Whilkut A person having origins in the original Hoopa Extension people. C43986 Population Group Hoopa Extension C1555228 Hoopa_Extension Hoopa Extension Hoopa Extension A person having origins in the original Houma people. C43987 Population Group Houma C1555229 Houma Houma Houma A person having origins in the original Inaja-Cosmit people. C43988 Population Group Inaja-Cosmit C1555230 Inaja_Cosmit Inaja-Cosmit Inaja-Cosmit A person having origins in the original Iowa people. C43989 Population Group Iowa C1555231 Iowa_Indian Iowa Iowa A person having origins in the original Iowa of Kansas-Nebraska people. C43990 Population Group Iowa of Kansas-Nebraska C1555232 Iowa_of_Kansas_Nebraska Iowa of Kansas-Nebraska Iowa of Kansas-Nebraska A person having origins in the original Iowa of Oklahoma people. C43991 Population Group Iowa of Oklahoma C1555233 Iowa_of_Oklahoma Iowa of Oklahoma Iowa of Oklahoma A person having origins in the original Iroquois people. C43992 Population Group Iroquois C0682098 Iroquois Iroquois Iroquois A person having origins in the original Juaneno people. C43993 Population Group Juaneno C1555243 Juaneno Juaneno Juaneno A person having origins in the original Kalispel people. C43994 Population Group Kalispel C1555244 Kalispel Kalispel Kalispel A person having origins in the original Karuk people. C43995 Population Group Karuk C1555245 Karuk Karuk Karuk A person having origins in the original Kaw people. C43996 Population Group Kaw C1555246 Kaw Kaw Kaw A person having origins in the original Kickapoo people. C43997 Population Group Kickapoo C1555247 Kickapoo Kickapoo Kickapoo A person having origins in the original Oklahoma Kickapoo people. C43998 Population Group Oklahoma Kickapoo C1555248 Oklahoma_Kickapoo Oklahoma Kickapoo Oklahoma Kickapoo A person having origins in the original Texas Kickapoo people. C43999 Population Group Texas Kickapoo C1555249 Texas_Kickapoo Texas Kickapoo Texas Kickapoo A person having origins in the original Kiowa people. C44000 Population Group Kiowa C1555250 Kiowa Kiowa Kiowa A person having origins in the original Oklahoma Kiowa people. C44001 Population Group Oklahoma Kiowa C1555251 Oklahoma_Kiowa Oklahoma Kiowa Oklahoma Kiowa A person having origins in the original Klallam people. C44002 Population Group Klallam C1555252 Klallam Klallam Klallam A person having origins in the original Jamestown people. C44003 Population Group Jamestown C1555253 Jamestown Jamestown Jamestown A person having origins in the original Lower Elwha people. C44004 Population Group Lower Elwha C1555254 Lower_Elwha Lower Elwha Lower Elwha A person having origins in the original Port Gamble Klallam people. C44005 Population Group Port Gamble Klallam C1555255 Port_Gamble_Klallam Port Gamble Klallam Port Gamble Klallam A person having origins in the original Klamath people. C44006 Population Group Klamath C1555256 Klamath Klamath Klamath A person having origins in the original Konkow people. C44007 Population Group Konkow C1555257 Konkow Konkow Konkow A person having origins in the original Kootenai people. C44008 Population Group Kootenai C1555258 Kootenai Kootenai Kootenai A person having origins in the original Lassik people. C44009 Population Group Lassik C1555259 Lassik Lassik Lassik A person having origins in the original Long Island people. C44010 Population Group Long Island C1555260 Long_Island Long Island Long Island A person having origins in the original Matinecock people. C44011 Population Group Matinecock C1555261 Matinecock Matinecock Matinecock A person having origins in the original Montauk people. C44012 Population Group Montauk C1555262 Montauk Montauk Montauk A person having origins in the original Poospatuck people. C44013 Population Group Poospatuck C1555263 Poospatuck Poospatuck Poospatuck A person having origins in the original Setauket people. C44014 Population Group Setauket C1555264 Setauket Setauket Setauket A person having origins in the original Luiseno people. C44015 Population Group Luiseno C0682114 Luiseno Luiseno Luiseno A person having origins in the original La Jolla people. C44016 Population Group La Jolla C1555265 La_Jolla La Jolla La Jolla A person having origins in the original Pala people. C44017 Population Group Pala C1555266 Pala Pala Pala A person having origins in the original Pauma people. C44018 Population Group Pauma C1555267 Pauma Pauma Pauma A person having origins in the original Pechanga people. C44019 Population Group Pechanga C1555268 Pechanga Pechanga Pechanga A person having origins in the original Soboba people. C44020 Population Group Soboba C1555269 Soboba SoboInOwlba Soboba A person having origins in the original Twenty-Nine Palms people. C44021 Population Group Twenty-Nine Palms C1555270 Twenty_Nine_Palms Twenty-Nine Palms Twenty-Nine Palms A person having origins in the original Temecula people. C44022 Population Group Temecula C1555271 Temecula Temecula Temecula A person having origins in the original Lumbee people. C44023 Population Group Lumbee C1555272 Lumbee Lumbee Lumbee A person having origins in the original Lummi people. C44024 Population Group Lummi C1555273 Lummi Lummi Lummi A person having origins in the original Maidu people. C44025 Population Group Maidu C1555274 Maidu Maidu Maidu A person having origins in the original Mountain Maidu people. C44026 Population Group Mountain Maidu C1555275 Mountain_Maidu Mountain Maidu Mountain Maidu A person having origins in the original Nishinam people. C44027 Population Group Nishinam C1551415 Nishinam Nishinam Nishinam A person having origins in the original Makah people. C44028 Population Group Makah C1551416 Makah Makah Makah A person having origins in the original Maliseet people. C44029 Population Group Maliseet C1551417 Maliseet Maliseet Maliseet A person having origins in the original Mandan people. C44030 Population Group Mandan C1551418 Mandan Mandan Mandan A person having origins in the original Mattaponi people. C44031 Population Group Mattaponi C1551419 Mattaponi Mattaponi Mattaponi A person having origins in the original Menominee people. C44032 Population Group Menominee C1551420 Menominee Menominee Menominee A person having origins in the original Miami people. C44033 Population Group Miami C1551421 Miami Miami Miami A person having origins in the original Illinois Miami people. C44034 Population Group Illinois Miami C1551422 Illinois_Miami Illinois Miami Illinois Miami A person having origins in the original Indiana Miami people. C44035 Population Group Indiana Miami C1551423 Indiana_Miami Indiana Miami Indiana Miami A person having origins in the original Oklahoma Miami people. C44036 Population Group Oklahoma Miami C1551424 Oklahoma_Miami Oklahoma Miami Oklahoma Miami A person having origins in the original Miccosukee people. C44037 Population Group Miccosukee C1551425 Miccosukee Miccosukee Miccosukee A person having origins in the original Micmac people. C44038 Population Group Micmac C1551426 Micmac Micmac Micmac A person having origins in the original Aroostook people. C44039 Population Group Aroostook C1551427 Aroostook Aroostook Aroostook A person having origins in the original Mission Indians people. C44040 Population Group Mission Indians C1551428 Mission_Indians Mission Indians Mission Indians A person having origins in the original Miwok people. C44041 Population Group Miwok C1551429 Miwok Miwok Miwok A person having origins in the original Modoc people. C44042 Population Group Modoc C1551430 Modoc Modoc Modoc A person having origins in the original Mohegan people. C44043 Population Group Mohegan C1551431 Mohegan Mohegan Mohegan A person having origins in the original Mono people. C44044 Population Group Mono C1551432 Mono Mono Mono A person having origins in the original Nanticoke people. C44045 Population Group Nanticoke C1551433 Nanticoke Nanticoke Nanticoke A person having origins in the original Narragansett people. C44046 Population Group Narragansett C1551434 Narragansett Narragansett Narragansett A person having origins in the original Navajo people. C44048 Population Group Navajo C0337879 Dine Dine Navaho Navajo Navajo A person having origins in the original Alamo Navajo people. C44049 Population Group Alamo Navajo C1551435 Alamo_Dine Alamo Dine Alamo Navaho Alamo Navajo Alamo Navajo A person having origins in the original Canoncito Navajo people. C44050 Population Group Canoncito Navajo C1551436 Canoncito_Dine Canoncito Dine Canoncito Navaho Canoncito Navajo Canoncito Navajo A person having origins in the original Ramah Navajo people. C44051 Population Group Ramah Navajo C1551437 Ramah_Dine Ramah Dine Ramah Navaho Ramah Navajo Ramah Navajo A person having origins in the original Nez Perce people. C44052 Population Group Nez Perce C0337880 Nez_Perce Nez Perce Nez Percé Nez Perce A person having origins in the original Nomalaki people. C44053 Population Group Nomalaki C1551438 Nomalaki Nomalaki Nomalaki A person having origins in the original Northwest Tribes people. C44054 Population Group Northwest Tribes C1551439 Northwest_Tribes Northwest Tribes Northwest Tribes A person having origins in the original Alsea people. C44055 Population Group Alsea C1551440 Alsea Alsea Alsea A person having origins in the original Celilo people. C44056 Population Group Celilo C1551441 Celilo Celilo Celilo A person having origins in the original Columbia people. C44057 Population Group Columbia C1551442 Columbia_Indian Columbia Columbia A person having origins in the original Kalapuya people. C44058 Population Group Kalapuya C1551443 Kalapuya Kalapuya Kalapuya A person having origins in the original Molala people. C44059 Population Group Molala C1551444 Molala Molala Molala A person having origins in the original Talakamish people. C44060 Population Group Talakamish C1551445 Talakamish Talakamish Talakamish A person having origins in the original Tenino people. C44061 Population Group Tenino C1551446 Tenino Tenino Tenino A person having origins in the original Tillamook people. C44062 Population Group Tillamook C1551447 Tillamook Tillamook Tillamook A person having origins in the original Wenatchee people. C44063 Population Group Wenatchee C1551448 Wenatchee Wenatchee Wenatchee A person having origins in the original Yahooskin people. C44064 Population Group Yahooskin C1551449 Yahooskin Yahooskin Yahooskin A person having origins in the original Omaha people. C44065 Population Group Omaha C1551450 Omaha Omaha Omaha A person having origins in the original Oregon Athabaskan people. C44066 Population Group Oregon Athabaskan C1551451 Oregon_Athabaskan Oregon Athabaskan Oregon Athabaskan A person having origins in the original Osage people. C44067 Population Group Osage C1551452 Osage Osage Osage A person having origins in the original Otoe-Missouria people. C44068 Population Group Otoe-Missouria C1551453 Otoe_Missouria Otoe-Missouria Otoe-Missouria A person having origins in the original Ottawa people. C44069 Population Group Ottawa C1551454 Ottawa Ottawa Ottawa A person having origins in the original Burt Lake Ottawa people. C44070 Population Group Burt Lake Ottawa C1551455 Burt_Lake_Ottawa Burt Lake Ottawa Burt Lake Ottawa A person having origins in the original Michigan Ottawa people. C44071 Population Group Michigan Ottawa C1551456 Michigan_Ottawa Michigan Ottawa Michigan Ottawa A person having origins in the original Oklahoma Ottawa people. C44072 Population Group Oklahoma Ottawa C1551457 Oklahoma_Ottawa Oklahoma Ottawa Oklahoma Ottawa A person having origins in the original Paiute people. C44073 Population Group Paiute C0682113 Paiute Paiute Paiute A person having origins in the original Pamunkey people. C44074 Population Group Pamunkey C1551479 Pamunkey Pamunkey Pamunkey A person having origins in the original Passamaquoddy people. C44075 Population Group Passamaquoddy C1551480 Passamaquoddy Passamaquoddy Passamaquoddy A person having origins in the original Indian Township people. C44076 Population Group Indian Township C1551481 Indian_Township Indian Township Indian Township A person having origins in the original Pleasant Point Passamaquoddy people. C44077 Population Group Pleasant Point Passamaquoddy C1551482 Pleasant_Point_Passamaquoddy Pleasant Point Passamaquoddy Pleasant Point Passamaquoddy A person having origins in the original Pawnee people. C44078 Population Group Pawnee C0682108 Pawnee Pawnee Pawnee A person having origins in the original Oklahoma Pawnee people. C44079 Population Group Oklahoma Pawnee C1551483 Oklahoma_Pawnee Oklahoma Pawnee Oklahoma Pawnee A person having origins in the original Penobscot people. C44080 Population Group Penobscot C0682097 Penobscot Penobscot Penobscot A person having origins in the original Peoria people. C44081 Population Group Peoria C1551484 Peoria Peoria Peoria A person having origins in the original Oklahoma Peoria people. C44082 Population Group Oklahoma Peoria C1551485 Oklahoma_Peoria Oklahoma Peoria Oklahoma Peoria A person having origins in the original Pequot people. C44083 Population Group Pequot C1551486 Pequot Pequot Pequot A person having origins in the original Marshantucket Pequot people. C44084 Population Group Marshantucket Pequot C1551487 Marshantucket_Pequot Marshantucket Pequot Marshantucket Pequot A person having origins in the original Pima people. C44085 Population Group Pima C1551488 Pima Pima Pima A person having origins in the original Gila River Pima-Maricopa people. C44086 Population Group Gila River Pima-Maricopa C1551489 Gila_River_Pima_Maricopa Gila River Pima-Maricopa Gila River Pima-Maricopa A person having origins in the original Salt River Pima-Maricopa people. C44087 Population Group Salt River Pima-Maricopa C1551490 Salt_River_Pima_Maricopa Salt River Pima-Maricopa Salt River Pima-Maricopa A person having origins in the original Piscataway people. C44088 Population Group Piscataway C1551491 Piscataway Piscataway Piscataway A person having origins in the original Pit River people. C44089 Population Group Pit River C1551492 Pit_River Pit River Pit River A person having origins in the original Pomo people. C44090 Population Group Pomo C1551493 Pomo Pomo Pomo A person having origins in the original Ponca people. C44091 Population Group Ponca C1551502 Ponca Ponca Ponca A person having origins in the original Nebraska Ponca people. C44092 Population Group Nebraska Ponca C1551503 Nebraska_Ponca Nebraska Ponca Nebraska Ponca A person having origins in the original Oklahoma Ponca people. C44093 Population Group Oklahoma Ponca C1551504 Oklahoma_Ponca Oklahoma Ponca Oklahoma Ponca A person having origins in the original Potawatomi people. C44094 Population Group Potawatomi C1551505 Potawatomi Potawatomi Potawatomi A person having origins in the original Powhatan people. C44095 Population Group Powhatan C1551513 Powhatan Powhatan Powhatan A person having origins in the original Pueblo people. C44096 Population Group Pueblo C1556090 Pueblo Pueblo Pueblo A person having origins in the original Puget Sound Salish people. C44102 Population Group Puget Sound Salish C1551539 Puget_Sound_Salish Puget Sound Salish Puget Sound Salish A person having origins in the original Quapaw people. C44103 Population Group Quapaw C1551561 Quapaw Quapaw Quapaw A person having origins in the original Quinault people. C44104 Population Group Quinault C1551562 Quinault Quinault Quinault A person having origins in the original Rappahannock people. C44105 Population Group Rappahannock C1551563 Rappahannock Rappahannock Rappahannock A person having origins in the original Reno-Sparks people. C44106 Population Group Reno-Sparks C1551564 Reno_Sparks Reno-Sparks Reno-Sparks A person having origins in the original Round Valley people. C44107 Population Group Round Valley C1551565 Round_Valley Round Valley Round Valley A person having origins in the original Sac and Fox people. C44108 Population Group Sac and Fox C1551566 Sac_and_Fox Sac and Fox Sac and Fox A person having origins in the original Iowa Sac and Fox people. C44109 Population Group Iowa Sac and Fox C1551567 Iowa_Sac_and_Fox Iowa Sac and Fox Iowa Sac and Fox A person having origins in the original Missouri Sac and Fox people. C44110 Population Group Missouri Sac and Fox C1551568 Missouri_Sac_and_Fox Missouri Sac and Fox Missouri Sac and Fox A person having origins in the original Oklahoma Sac and Fox people. C44111 Population Group Oklahoma Sac and Fox C1551569 Oklahoma_Sac_and_Fox Oklahoma Sac and Fox Oklahoma Sac and Fox A person having origins in the original Salinan people. C44112 Population Group Salinan C1551570 Salinan Salinan Salinan A person having origins in the original Salish people. C44113 Population Group Salish C1551571 Salish Salish Salish A person having origins in the original Salish and Kootenai people. C44114 Population Group Salish and Kootenai C1551572 Salish_and_Kootenai Salish and Kootenai Salish and Kootenai A person having origins in the original Schaghticoke people. C44115 Population Group Schaghticoke C1551573 Schaghticoke Schaghticoke Schaghticoke A person having origins in the original Scott Valley people. C44116 Population Group Scott Valley C1551574 Scott_Valley Scott Valley Scott Valley A person having origins in the original Seminole people. C44117 Population Group Seminole C1556091 Seminole Seminole Seminole A person having origins in the original Big Cypress people. C44118 Population Group Big Cypress C1551575 Big_Cypress Big Cypress Big Cypress A person having origins in the original Brighton people. C44119 Population Group Brighton C1551576 Brighton Brighton Brighton A person having origins in the original Florida Seminole people. C44120 Population Group Florida Seminole C1551577 Florida_Seminole Florida Seminole Florida Seminole A person having origins in the original Hollywood Seminole people. C44121 Population Group Hollywood Seminole C1551578 Hollywood_Seminole Hollywood Seminole Hollywood Seminole A person having origins in the original Oklahoma Seminole people. C44122 Population Group Oklahoma Seminole C1551579 Oklahoma_Seminole Oklahoma Seminole Oklahoma Seminole A person having origins in the original Serrano people. C44123 Population Group Serrano C1551580 Serrano Serrano Serrano A person having origins in the original San Manual people. C44124 Population Group San Manual C1551581 San_Manual San Manual San Manual A person having origins in the original Shasta people. C44125 Population Group Shasta C1551582 Shasta Shasta Shasta A person having origins in the original Shawnee people. C44126 Population Group Shawnee C1551583 Shawnee Shawnee Shawnee A person having origins in the original Absentee Shawnee people. C44127 Population Group Absentee Shawnee C1551584 Absentee_Shawnee Absentee Shawnee Absentee Shawnee A person having origins in the original Eastern Shawnee people. C44128 Population Group Eastern Shawnee C1551585 Eastern_Shawnee Eastern Shawnee Eastern Shawnee A person having origins in the original Shinnecock people. C44129 Population Group Shinnecock C1551586 Shinnecock Shinnecock Shinnecock A person having origins in the original Shoalwater Bay people. C44130 Population Group Shoalwater Bay C1551587 Shoalwater_Bay Shoalwater Bay Shoalwater Bay A person having origins in the original Shoshone people. C44131 Population Group Shoshone C0337886 Shoshone Shoshone Shoshone A person having origins in the original Shoshone Paiute people. C44132 Population Group Shoshone Paiute C1551602 Shoshone_Paiute Shoshone Paiute Shoshone Paiute A person having origins in the original Duck Valley people. C44133 Population Group Duck Valley C1551603 Duck_Valley Duck Valley Duck Valley A person having origins in the original Fallon people. C44134 Population Group Fallon C1551604 Fallon Fallon Fallon A person having origins in the original Fort McDermitt people. C44135 Population Group Fort McDermitt C1551605 Fort_McDermitt Fort McDermitt Fort McDermitt A person having origins in the original Siletz people. C44136 Population Group Siletz C1551606 Siletz Siletz Siletz A person having origins in the original Sioux people. C44137 Population Group Sioux C0682107 Sioux Sioux Sioux A person having origins in the original Blackfoot Sioux people. C44138 Population Group Blackfoot Sioux C1551607 Blackfoot_Sioux Blackfoot Sioux Blackfoot Sioux A person having origins in the original Brule Sioux people. C44139 Population Group Brule Sioux C1551608 Brule_Sioux Brule Sioux Brule Sioux A person having origins in the original Cheyenne River Sioux people. C44140 Population Group Cheyenne River Sioux C1551609 Cheyenne_River_Sioux Cheyenne River Sioux Cheyenne River Sioux A person having origins in the original Teton Sioux people. C44141 Population Group Teton Sioux C1551631 Lakota Teton Sioux Teton Sioux A person having origins in the original Dakota Sioux people. C44142 Population Group Dakota Sioux C1551611 Dakota Dakota Sioux Dakota Sioux A person having origins in the original Nakota people. C44143 Population Group Nakota CL448673 Nakota Nakota Nakota Sioux Nakota A person having origins in the original Crow Creek Sioux people. C44144 Population Group Crow Creek Sioux C1551610 Crow_Creek_Sioux Crow Creek Sioux Crow Creek Sioux A person having origins in the original Flandreau Santee people. C44145 Population Group Flandreau Santee C1551612 Flandreau_Santee Flandreau Santee Flandreau Santee A person having origins in the original Lake Traverse Sioux people. C44146 Population Group Lake Traverse Sioux C1551614 Lake_Traverse_Sioux Lake Traverse Sioux Lake Traverse Sioux A person having origins in the original Fort Peck people. C44147 Population Group Fort Peck C1551613 Fort_Peck_Sioux Fort Peck Fort Peck A person having origins in the original Lower Brule Sioux people. C44148 Population Group Lower Brule Sioux C1551615 Lower_Brule_Sioux Lower Brule Sioux Lower Brule Sioux A person having origins in the original Lower Sioux people. C44149 Population Group Lower Sioux C1551616 Lower_Sioux Lower Sioux Lower Sioux A person having origins in the original Mdewakanton Sioux people. C44150 Population Group Mdewakanton Sioux C1551617 Mdewakanton_Sioux Mdewakanton Sioux Mdewakanton Sioux A person having origins in the original Miniconjou people. C44151 Population Group Miniconjou C1551618 Miniconjou Miniconjou Miniconjou A person having origins in the original Oglala Sioux people. C44152 Population Group Oglala Sioux C1551619 Oglala_Sioux Oglala Sioux Oglala Sioux A person having origins in the original Pine Ridge Sioux people. C44153 Population Group Pine Ridge Sioux C1551620 Pine_Ridge_Sioux Pine Ridge Sioux Pine Ridge Sioux A person having origins in the original Pipestone Sioux people. C44154 Population Group Pipestone Sioux C1551621 Pipestone_Sioux Pipestone Sioux Pipestone Sioux A person having origins in the original Prairie Island Sioux people. C44155 Population Group Prairie Island Sioux C1551622 Prairie_Island_Sioux Prairie Island Sioux Prairie Island Sioux A person having origins in the original Prior Lake Sioux people. C44156 Population Group Prior Lake Sioux C1551623 Prior_Lake_Sioux Prior Lake Sioux Prior Lake Sioux A person having origins in the original Rosebud Sioux people. C44157 Population Group Rosebud Sioux C1551624 Rosebud_Sioux Rosebud Sioux Rosebud Sioux A person having origins in the original Sans Arc Sioux people. C44158 Population Group Sans Arc Sioux C1551625 Sans_Arc_Sioux Sans Arc Sioux Sans Arc Sioux A person having origins in the original Santee Sioux people. C44159 Population Group Santee Sioux C1551626 Santee_Sioux Santee Sioux Santee Sioux A person having origins in the original Sisseton-Wahpeton people. C44160 Population Group Sisseton-Wahpeton C1551627 Sisseton_Wahpeton Sisseton-Wahpeton Sisseton-Wahpeton A person having origins in the original Sisseton Sioux people. C44161 Population Group Sisseton Sioux C1551628 Sisseton_Sioux Sisseton Sioux Sisseton Sioux A person having origins in the original Wahpeton Sioux people. C44162 Population Group Wahpeton Sioux C1551635 Wahpeton_Sioux Wahpeton Sioux Wahpeton Sioux A person having origins in the original Spirit Lake Sioux people. C44163 Population Group Spirit Lake Sioux C1551629 Spirit_Lake_Sioux Spirit Lake Sioux Spirit Lake Sioux A person having origins in the original Standing Rock Sioux people. C44164 Population Group Standing Rock Sioux C1551630 Standing_Rock_Sioux Standing Rock Sioux Standing Rock Sioux A person having origins in the original Two Kettle Sioux people. C44165 Population Group Two Kettle Sioux C1551632 Two_Kettle_Sioux Two Kettle Sioux Two Kettle Sioux A person having origins in the original Upper Sioux people. C44187 Population Group Upper Sioux C1551633 Upper_Sioux Upper Sioux Upper Sioux A person having origins in the original Wahpekute Sioux people. C44188 Population Group Wahpekute Sioux C1551634 Wahpekute_Sioux Wahpekute Sioux Wahpekute Sioux A person having origins in the original Wazhaza Sioux people. C44189 Population Group Wazhaza Sioux C1551636 Wazhaza_Sioux Wazhaza Sioux Wazhaza Sioux A person having origins in the original Yankton Sioux people. C44190 Population Group Yankton Sioux C1551637 Yankton_Sioux Yankton Sioux Yankton Sioux A person having origins in the original Yanktonai Sioux people. C44191 Population Group Yanktonai Sioux C1551638 Yanktonai_Sioux Yanktonai Sioux Yanktonai Sioux A person having origins in the original Siuslaw people. C44192 Population Group Siuslaw C1551639 Siuslaw Siuslaw Siuslaw A person having origins in the original Spokane people. C44193 Population Group Spokane C1551640 Spokane Spokane Spokane A person having origins in the original Stewart people. C44194 Population Group Stewart C1551641 Stewart Stewart Stewart A person having origins in the original Stockbridge people. C44195 Population Group Stockbridge C1551642 Stockbridge Stockbridge Stockbridge A person having origins in the original Susanville people. C44196 Population Group Susanville C1551643 Susanville Susanville Susanville A person having origins in the original Tohono O'Odham people. C44197 Population Group Tohono O'Odham C1551644 Tohono_O_Odham Tohono O'Odham Tohono O'Odham A person having origins in the original Ak-Chin people. C44198 Population Group Ak-Chin C1551645 Ak_Chin Ak-Chin Ak-Chin A person having origins in the original Gila Bend people. C44199 Population Group Gila Bend C1551646 Gila_Bend Gila Bend Gila Bend A person having origins in the original San Xavier people. C44200 Population Group San Xavier C1551647 San_Xavier San Xavier San Xavier A person having origins in the original Sells people. C44201 Population Group Sells C1551648 Sells Sells Sells A person having origins in the original Tolowa people. C44202 Population Group Tolowa C1551649 Tolowa Tolowa Tolowa A person having origins in the original Tonkawa people. C44203 Population Group Tonkawa C1551650 Tonkawa Tonkawa Tonkawa A person having origins in the original Tygh people. C44204 Population Group Tygh C1551651 Tygh Tygh Tygh A person having origins in the original Umatilla people. C44205 Population Group Umatilla C1551652 Umatilla Umatilla Umatilla A person having origins in the original Umpqua people. C44206 Population Group Umpqua C1551653 Umpqua Umpqua Umpqua A person having origins in the original Cow Creek Umpqua people. C44207 Population Group Cow Creek Umpqua C1551654 Cow_Creek_Umpqua Cow Creek Umpqua Cow Creek Umpqua A person having origins in the original Ute people. C44208 Population Group Ute C1556092 Ute Ute Ute A person having origins in the original Allen Canyon people. C44209 Population Group Allen Canyon C1551655 Allen_Canyon Allen Canyon Allen Canyon A person having origins in the original Uintah Ute people. C44210 Population Group Uintah Ute C1551656 Uintah_Ute Uintah Ute Uintah Ute A person having origins in the original Ute Mountain Ute people. C44211 Population Group Ute Mountain Ute C1551657 Ute_Mountain_Ute Ute Mountain Ute Ute Mountain Ute A person having origins in the original Wailaki people. C44212 Population Group Wailaki C1551658 Wailaki Wailaki Wailaki A person having origins in the original Walla-Walla people. C44213 Population Group Walla-Walla C1551659 Walla_Walla Walla-Walla Walla-Walla A person having origins in the original Wampanoag people. C44214 Population Group Wampanoag C1551660 Wampanoag Wampanoag Wampanoag A person having origins in the original Gay Head Wampanoag people. C44215 Population Group Gay Head Wampanoag C1551661 Gay_Head_Wampanoag Gay Head Wampanoag Gay Head Wampanoag A person having origins in the original Mashpee Wampanoag people. C44216 Population Group Mashpee Wampanoag C1551662 Mashpee_Wampanoag Mashpee Wampanoag Mashpee Wampanoag A person having origins in the original Warm Springs people. C44217 Population Group Warm Springs C1551663 Warm_Springs Warm Springs Warm Springs A person having origins in the original Wascopum people. C44218 Population Group Wascopum C1551664 Wascopum Wascopum Wascopum A person having origins in the original Washoe people. C44219 Population Group Washoe C1551665 Washoe Washoe Washoe A person having origins in the original Alpine people. C44220 Population Group Alpine C1551666 Alpine Alpine Alpine A person having origins in the original Carson people. C44221 Population Group Carson C1551667 Carson Carson Carson A person having origins in the original Dresslerville people. C44222 Population Group Dresslerville C1551668 Dresslerville Dresslerville Dresslerville A person having origins in the original Wichita people. C44223 Population Group Wichita C1551669 Wichita Wichita Wichita A person having origins in the original Wind River people. C44224 Population Group Wind River C1551670 Wind_River Wind River Wind River A person having origins in the original Winnebago people. C44225 Population Group Winnebago C1551671 Winnebago Winnebago Winnebago A person having origins in the original Ho-Chunk people. C44226 Population Group Ho-Chunk C1551672 Ho_Chunk Ho-Chunk Ho-chunk Ho-Chunk A person having origins in the original Nebraska Winnebago people. C44227 Population Group Nebraska Winnebago C1550782 Nebraska Winnebago Nebraska Winnebago A person having origins in the original Winnemucca people. C44228 Population Group Winnemucca C1551674 Winnemucca Winnemucca Winnemucca A person having origins in the original Wintun people. C44229 Population Group Wintun C1551675 Wintun Wintun Wintun A person having origins in the original Wiyot people. C44230 Population Group Wiyot C1551676 Wiyot Wiyot Wiyot A person having origins in the original Table Bluff people. C44231 Population Group Table Bluff C1551677 Table_Bluff Table Bluff Table Bluff A person having origins in the original Yakama people. C44232 Population Group Yakama C1551678 Yakama Yakama Yakama A person having origins in the original Yakama Cowlitz people. C44233 Population Group Yakama Cowlitz C1551679 Yakama_Cowlitz Yakama Cowlitz Yakama Cowlitz A person having origins in the original Yaqui people. C44234 Population Group Yaqui C1551680 Yaqui Yaqui Yaqui A person having origins in the original Barrio Libre people. C44236 Population Group Barrio Libre C1551681 Barrio_Libre Barrio Libre Barrio Libre A person having origins in the original Pascua Yaqui people. C44237 Population Group Pascua Yaqui C1551682 Pascua_Yaqui Pascua Yaqui Pascua Yaqui A person having origins in the original Yavapai Apache people. C44238 Population Group Yavapai Apache C1551683 Yavapai_Apache Yavapai Apache Yavapai Apache A person having origins in the original Yokuts people. C44239 Population Group Yokuts C1551684 Yokuts Yokuts Yokuts A person having origins in the original Chukchansi people. C44240 Population Group Chukchansi C1551685 Chukchansi Chukchansi Chukchansi A person having origins in the original Tachi people. C44241 Population Group Tachi C1551686 Tachi Tachi Tachi A person having origins in the original Tule River people. C44242 Population Group Tule River C1551687 Tule_River Tule River Tule River A person having origins in the original Yuchi people. C44244 Population Group Yuchi C1551688 Yuchi Yuchi Yuchi A person having origins in the original Yuman people. C44245 Population Group Yuman C1551689 Yuman Yuman Yuman A person having origins in the original Cocopah people. C44246 Population Group Cocopah C1551690 Cocopah Cocopah Cocopah A person having origins in the original Havasupai people. C44247 Population Group Havasupai C1551691 Havasupai Havasupai Havasupai A person having origins in the original Hualapai people. C44248 Population Group Hualapai C1551692 Hualapai Hualapai Hualapai A person having origins in the original Maricopa people. C44249 Population Group Maricopa C1551693 Maricopa Maricopa Maricopa A person having origins in the original Mohave people. C44250 Population Group Mohave C1551694 Mohave Mohave Mohave A person having origins in the original Quechan people. C44251 Population Group Quechan C1551695 Quechan Quechan Quechan A person having origins in the original Yurok people. C44252 Population Group Yurok C1551697 Yurok Yurok Yurok A person having origins in the original Coast Yurok people. C44253 Population Group Coast Yurok C1551698 Coast_Yurok Coast Yurok Coast Yurok A person having origins in the original Alaskan Athabascan people. C44254 Population Group Alaskan Athabascan C1551699 Alaskan_Athabascan Alaskan Athabascan Alaskan Athabascan A person having origins in the original Southeast Alaska people. C44257 Population Group Southeast Alaska C1551770 Southeast_Alaska Southeast Alaska Southeast Alaska A person having origins in the original Tlingit-Haida people. C44259 Population Group Tlingit-Haida C1551771 Tlingit_Haida Tlingit-Haida Tlinit-Haida Tlingit-Haida A person having origins in the original Tsimshian people. C44261 Population Group Tsimshian C1551792 Tsimshian Tsimshian Tsimshian A person having origins in the original Metlakatla people. C44263 Population Group Metlakatla C1551793 Metlakatla Metlakatla Metlakatla A person having origins in the original Greenland Eskimo people. C44265 Population Group Greenland Eskimo C1551794 CDISC The native people of Greenland. Greenland_Eskimo GREENLAND INUIT Greenland Eskimo Greenland Inuit Greenland Eskimo A person having origins in the original Inupiat Eskimo people. C44268 Population Group Inupiat Eskimo C1551795 CDISC The native people inhabiting the territory spanning the Norton Sound on the Bering Sea to the Canadian border. Inupiat_Eskimo INUPIAT INUIT Inupiat Eskimo Inupiat Eskimo A person having origins in the original Siberian Eskimo people. C44269 Population Group Siberian Eskimo C1551841 CDISC The native Yupik people inhabiting the coast of the Chukchi Peninsula in the far northeast of the Russian Federation and on St. Lawrence Island in Alaska. Siberian_Eskimo SIBERIAN ESKIMO Siberian Eskimo Siberian Eskimo A person having origins in the original Yupik Eskimo people. C44270 Population Group Yupik Eskimo C1551845 CDISC The native people inhabiting western, southwestern, and southcentral Alaska and the Russian Far East. Yupik_Eskimo YUPIK ESKIMO Yupik Eskimo Yupik Eskimo A person having origins in the original Alutiiq Aleut people. C44286 Population Group Alutiiq Aleut C1553271 Alutiiq_Aleut Alutiiq Aleut Alutiiq Aleut A person having origins in the original Tatitlek people. C44287 Population Group Tatitlek C1553272 Tatitlek Tatitlek Tatitlek A person having origins in the original Ugashik people. C44288 Population Group Ugashik C1553273 Ugashik Ugashik Ugashik A person having origins in the original Bristol Bay Aleut people. C44289 Population Group Bristol Bay Aleut C1553507 Bristol_Bay_Aleut Bristol Bay Aleut Bristol Bay Aleut A person having origins in the original Chugach Aleut people. C44290 Population Group Chugach Aleut C1553284 Chugach_Aleut Chugach Aleut Chugach Aleut A person having origins in the original Eyak people. C44486 Population Group Eyak C1553289 Eyak Eyak Eyak A person having origins in the original Koniag Aleut people. C44487 Population Group Koniag Aleut C1553290 Koniag_Aleut Koniag Aleut Koniag Aleut A person having origins in the original Sugpiaq people. C44488 Population Group Sugpiaq C1553299 Sugpiaq Sugpiaq Sugpiaq A person having origins in the original Suqpigaq people. C44489 Population Group Suqpigaq C1553300 Suqpigaq Suqpigaq Suqpigaq A person having origins in the original Unangan Aleut people. C44490 Population Group Unangan Aleut C1553301 Unangan_Aleut Unangan Aleut Unangan Aleut A person having origins in the original Chenega people. C44491 Population Group Chenega C1553285 Chenega Chenega Chenega A person having origins in the original Chugach Corporation people. C44492 Population Group Chugach Corporation C1553286 Chugach_Corporation Chugach Corporation Chugach Corporation A person having origins in the original English Bay people. C44493 Population Group English Bay C1553287 English_Bay English Bay English Bay A person having origins in the original Port Graham people. C44494 Population Group Port Graham C1553288 Port_Graham Port Graham Port Graham A person having origins in the original Akhiok people. C44495 Population Group Akhiok C1553291 Akhiok Akhiok Akhiok A person having origins in the original Agdaagux people. C44496 Population Group Agdaagux C1553292 Agdaagux Agdaagux Agdaagux A person having origins in the original Karluk people. C44497 Population Group Karluk C1553293 Karluk Karluk Karluk A person having origins in the original Kodiak people. C44498 Population Group Kodiak C1553294 Kodiak Kodiak Kodiak A person having origins in the original Larsen Bay people. C44499 Population Group Larsen Bay C1553295 Larsen_Bay Larsen Bay Larsen Bay A person having origins in the original Old Harbor people. C44500 Population Group Old Harbor C1553296 Old_Harbor Old Harbor Old Harbor A person having origins in the original Ouzinkie people. C44501 Population Group Ouzinkie C1553297 Ouzinkie Ouzinkie Ouzinkie A person having origins in the original Port Lions people. C44502 Population Group Port Lions C1553298 Port_Lions Port Lions Port Lions A person having origins in the original Gambell people. C44503 Population Group Gambell C1551842 Gambell Gambell Gambell A person having origins in the original Savoonga people. C44504 Population Group Savoonga C1551843 Savoonga Savoonga Savoonga A person having origins in the original Siberian Yupik people. C44505 Population Group Siberian Yupik C1551844 Siberian_Yupik Siberian Yupik Siberian Yupik A person having origins in the original Cahto people. C44506 Population Group Cahto C1555070 Cahto Cahto Cahto A person having origins in the original Chimariko people. C44507 Population Group Chimariko C1555071 Chimariko Chimariko Chimariko A person having origins in the original Coast Miwok people. C44508 Population Group Coast Miwok C1555072 Coast_Miwok Coast Miwok Coast Miwok A person having origins in the original Digger people. C44509 Population Group Digger C1555073 Digger Digger Digger A person having origins in the original Kawaiisu people. C44510 Population Group Kawaiisu C1555074 Kawaiisu Kawaiisu Kawaiisu A person having origins in the original Kern River people. C44511 Population Group Kern River C1555075 Kern_River Kern River Kern River A person having origins in the original Mattole people. C44512 Population Group Mattole C1555076 Mattole Mattole Mattole A person having origins in the original Red Wood people. C44513 Population Group Red Wood C1555077 Red_Wood Red Wood Red Wood A person having origins in the original Santa Rosa people. C44514 Population Group Santa Rosa C1555078 Santa_Rosa Santa Rosa Santa Rosa A person having origins in the original Takelma people. C44515 Population Group Takelma C1555079 Takelma Takelma Takelma A person having origins in the original Wappo people. C44516 Population Group Wappo C1555080 Wappo Wappo Wappo A person having origins in the original Yana people. C44517 Population Group Yana C1555081 Yana Yana Yana A person having origins in the original Yuki people. C44518 Population Group Yuki C1555082 Yuki Yuki Yuki A person having origins in the original Campo people. C44525 Population Group Campo C1555189 Campo Campo Campo A person having origins in the original Capitan Grande people. C44526 Population Group Capitan Grande C1555190 Capitan_Grande Capitan Grande Capitan Grande A person having origins in the original Cuyapaipe people. C44527 Population Group Cuyapaipe C1555191 Cuyapaipe Cuyapaipe Cuyapaipe A person having origins in the original La Posta people. C44528 Population Group La Posta C1555192 La_Posta La Posta La Posta A person having origins in the original Manzanita people. C44529 Population Group Manzanita C1555193 Manzanita Manzanita Manzanita A person having origins in the original Mesa Grande people. C44530 Population Group Mesa Grande C1555194 Mesa_Grande Mesa Grande Mesa Grande A person having origins in the original San Pasqual people. C44531 Population Group San Pasqual C1555195 San_Pasqual San Pasqual San Pasqual A person having origins in the original Santa Ysabel people. C44532 Population Group Santa Ysabel C1555196 Santa_Ysabel Santa Ysabel Santa Ysabel A person having origins in the original Sycuan people. C44533 Population Group Sycuan C1555197 Sycuan Sycuan Sycuan A person having origins in the original Bishop people. C44534 Population Group Bishop C1551458 Bishop Bishop A person having origins in the original Bridgeport people. C44535 Population Group Bridgeport C1551459 Bridgeport Bridgeport Bridgeport A person having origins in the original Burns Paiute people. C44536 Population Group Burns Paiute C1551460 Burns_Paiute Burns Paiute Burns Paiute A person having origins in the original Cedarville people. C44537 Population Group Cedarville C1551461 Cedarville Cedarville Cedarville A person having origins in the original Fort Bidwell people. C44538 Population Group Fort Bidwell C1551462 Fort_Bidwell Fort Bidwell Fort Bidwell A person having origins in the original Fort Independence people. C44539 Population Group Fort Independence C1551463 Fort_Independence Fort Independence Fort Independence A person having origins in the original Kaibab people. C44540 Population Group Kaibab C1551464 Kaibab Kaibab Kaibab A person having origins in the original Las Vegas people. C44541 Population Group Las Vegas C1551465 Las_Vegas Las Vegas Las Vegas A person having origins in the original Lone Pine people. C44542 Population Group Lone Pine C1551466 Lone_Pine Lone Pine Lone Pine A person having origins in the original Lovelock people. C44543 Population Group Lovelock C1551467 Lovelock Lovelock Lovelock A person having origins in the original Malheur Paiute people. C44544 Population Group Malheur Paiute C1551468 Malheur_Paiute Malheur Paiute Malheur Paiute A person having origins in the original Moapa people. C44545 Population Group Moapa C1551469 Moapa Moapa Moapa A person having origins in the original Northern Paiute people. C44546 Population Group Northern Paiute C1551470 Northern_Paiute Northern Paiute Northern Paiute A person having origins in the original Owens Valley people. C44547 Population Group Owens Valley C1551471 Owens_Valley Owens Valley Owens Valley A person having origins in the original Pyramid Lake people. C44548 Population Group Pyramid Lake C1551472 Pyramid_Lake Pyramid Lake Pyramid Lake A person having origins in the original San Juan Southern Paiute people. C44549 Population Group San Juan Southern Paiute C1551473 San_Juan_Southern_Paiute San Juan Southern Paiute San Juan Southern Paiute A person having origins in the original Southern Paiute people. C44550 Population Group Southern Paiute C1551474 Southern_Paiute Southern Paiute Southern Paiute A person having origins in the original Summit Lake people. C44551 Population Group Summit Lake C1551475 Summit_Lake Summit Lake Summit Lake A person having origins in the original Utu Utu Gwaitu Paiute people. C44552 Population Group Utu Utu Gwaitu Paiute C1551476 Utu_Utu_Gwaitu_Paiute Utu Utu Gwaitu Paiute Utu Utu Gwaitu Paiute A person having origins in the original Walker River people. C44553 Population Group Walker River C1551477 Walker_River Walker River Walker River A person having origins in the original Yerington Paiute people. C44554 Population Group Yerington Paiute C1551478 Yerington_Paiute Yerington Paiute Yerington Paiute A person having origins in the original Battle Mountain people. C44555 Population Group Battle Mountain C1551588 Battle_Mountain Battle Mountain Battle Mountain A person having origins in the original Duckwater people. C44556 Population Group Duckwater C1551589 Duckwater Duckwater Duckwater A person having origins in the original Elko people. C44557 Population Group Elko C1551590 Elko Elko Elko A person having origins in the original Ely people. C44558 Population Group Ely C1551591 Ely Ely Ely A person having origins in the original Goshute people. C44559 Population Group Goshute C1551592 Goshute Goshute Goshute A person having origins in the original Panamint people. C44560 Population Group Panamint C1551593 Panamint Panamint Panamint A person having origins in the original Ruby Valley people. C44561 Population Group Ruby Valley C1551594 Ruby_Valley Ruby Valley Ruby Valley A person having origins in the original Skull Valley people. C44562 Population Group Skull Valley C1551595 Skull_Valley Skull Valley Skull Valley A person having origins in the original South Fork Shoshone people. C44563 Population Group South Fork Shoshone C1551596 South_Fork_Shoshone South Fork Shoshone South Fork Shoshone A person having origins in the original Te-Moak Western Shoshone people. C44564 Population Group Te-Moak Western Shoshone C1551597 Te_Moak_Western_Shoshone Te-Moak Western Shoshone Te-Moak Western Shoshone A person having origins in the original Timbi-Sha Shoshone people. C44565 Population Group Timbi-Sha Shoshone C1551598 Timbi_Sha_Shoshone Timbi Sha Shoshone Timbi-Sha Shoshone Timbi-Sha Shoshone A person having origins in the original Washakie people. C44566 Population Group Washakie C1551599 Washakie Washakie Washakie A person having origins in the original Wind River Shoshone people. C44567 Population Group Wind River Shoshone C1551600 Wind_River_Shoshone Wind River Shoshone Wind River Shoshone A person having origins in the original Yomba people. C44568 Population Group Yomba C1551601 Yomba Yomba Yomba A person having origins in the original Akiachak people. C44569 Population Group Akiachak C1551846 Akiachak Akiachak Akiachak A person having origins in the original Akiak people. C44570 Population Group Akiak C1551847 Akiak Akiak Akiak A person having origins in the original Alakanuk people. C44571 Population Group Alakanuk C1551848 Alakanuk Alakanuk Alakanuk A person having origins in the original Aleknagik people. C44572 Population Group Aleknagik C1551849 Aleknagik Aleknagik Aleknagik A person having origins in the original Andreafsky people. C44573 Population Group Andreafsky C1551850 Andreafsky Andreafsky Andreafsky A person having origins in the original Aniak people. C44574 Population Group Aniak C1551851 Aniak Aniak Aniak A person having origins in the original Atmautluak people. C44575 Population Group Atmautluak C1551852 Atmautluak Atmautluak Atmautluak A person having origins in the original Bethel people. C44576 Population Group Bethel C1551853 Bethel Bethel Bethel A person having origins in the original Bill Moore's Slough people. C44577 Population Group Bill Moore's Slough C1551854 Bill_Moore_s_Slough Bill Moore's Slough Bill Moore's Slough A person having origins in the original Bristol Bay Yupik people. C44578 Population Group Bristol Bay Yupik C1551855 Bristol_Bay_Yupik Bristol Bay Yupik Bristol Bay Yupik A person having origins in the original Calista Yupik people. C44579 Population Group Calista Yupik C1551856 Calista_Yupik Calista Yupik Calista Yupik A person having origins in the original Chefornak people. C44580 Population Group Chefornak C1551857 Chefornak Chefornak Chefornak A person having origins in the original Chevak people. C44581 Population Group Chevak C1551858 Chevak Chevak Chevak A person having origins in the original Chuathbaluk people. C44582 Population Group Chuathbaluk C1551859 Chuathbaluk Chuathbaluk Chuathbaluk A person having origins in the original Clark's Point people. C44583 Population Group Clark's Point C1551860 Clark_s_Point Clark's Point Clark's Point A person having origins in the original Crooked Creek people. C44584 Population Group Crooked Creek C1551861 Crooked_Creek Crooked Creek Crooked Creek A person having origins in the original Dillingham people. C44585 Population Group Dillingham C1551862 Dillingham Dillingham Dillingham A person having origins in the original Eek people. C44586 Population Group Eek C1551863 Eek Eek Eek A person having origins in the original Ekuk people. C44587 Population Group Ekuk C1551864 Ekuk Ekuk Ekuk A person having origins in the original Ekwok people. C44588 Population Group Ekwok C1551865 Ekwok Ekwok Ekwok A person having origins in the original Emmonak people. C44589 Population Group Emmonak C1551866 Emmonak Emmonak Emmonak A person having origins in the original Goodnews Bay people. C44590 Population Group Goodnews Bay C1551867 Goodnews_Bay Goodnews Bay Goodnews Bay A person having origins in the original Hooper Bay people. C44591 Population Group Hooper Bay C1551868 Hooper_Bay Hooper Bay Hooper Bay A person having origins in the original Iqurmuit Russian Mission people. C44592 Population Group Iqurmuit Russian Mission C1551869 Iqurmuit_Russian_Mission Iqurmuit (Russian Mission) Iqurmuit Russian Mission Iqurmuit Russian Mission A person having origins in the original Kalskag people. C44593 Population Group Kalskag C1551870 Kalskag Kalskag Kalskag A person having origins in the original Kasigluk people. C44594 Population Group Kasigluk C1551871 Kasigluk Kasigluk Kasigluk A person having origins in the original Kipnuk people. C44595 Population Group Kipnuk C1551872 Kipnuk Kipnuk Kipnuk A person having origins in the original Koliganek people. C44596 Population Group Koliganek C1551873 Koliganek Koliganek Koliganek A person having origins in the original Kongiganak people. C44597 Population Group Kongiganak C1551874 Kongiganak Kongiganak Kongiganak A person having origins in the original Kotlik people. C44598 Population Group Kotlik C1551875 Kotlik Kotlik Kotlik A person having origins in the original Kwethluk people. C44599 Population Group Kwethluk C1551876 Kwethluk Kwethluk Kwethluk A person having origins in the original Kwigillingok people. C44600 Population Group Kwigillingok C1551877 Kwigillingok Kwigillingok Kwigillingok A person having origins in the original Levelock people. C44601 Population Group Levelock C1551878 Levelock Levelock Levelock A person having origins in the original Lower Kalskag people. C44602 Population Group Lower Kalskag C1551879 Lower_Kalskag Lower Kalskag Lower Kalskag A person having origins in the original Manokotak people. C44603 Population Group Manokotak C1551880 Manokotak Manokotak Manokotak A person having origins in the original Marshall people. C44604 Population Group Marshall C1551881 Marshall Marshall Marshall A person having origins in the original Mekoryuk people. C44605 Population Group Mekoryuk C1551882 Mekoryuk Mekoryuk Mekoryuk A person having origins in the original Mountain Village people. C44606 Population Group Mountain Village C1551883 Mountain_Village Mountain Village Mountain Village A person having origins in the original Naknek people. C44607 Population Group Naknek C1551884 Naknek Naknek Naknek A person having origins in the original Napaumute people. C44608 Population Group Napaumute C1551885 Napaumute Napaumute Napaumute A person having origins in the original Napakiak people. C44609 Population Group Napakiak C1551886 Napakiak Napakiak Napakiak A person having origins in the original Napaskiak people. C44610 Population Group Napaskiak C1551887 Napaskiak Napaskiak Napaskiak A person having origins in the original Newhalen people. C44611 Population Group Newhalen C1553245 Newhalen Newhalen Newhalen A person having origins in the original New Stuyahok people. C44612 Population Group New Stuyahok C1553246 New_Stuyahok New Stuyahok New Stuyahok A person having origins in the original Newtok people. C44613 Population Group Newtok C1553247 Newtok Newtok Newtok A person having origins in the original Nightmute people. C44614 Population Group Nightmute C1553248 Nightmute Nightmute Nightmute A person having origins in the original Nunapitchukv people. C44615 Population Group Nunapitchukv C1553249 Nunapitchukv Nunapitchukv Nunapitchukv A person having origins in the original Oscarville people. C44616 Population Group Oscarville C1553250 Oscarville Oscarville Oscarville A person having origins in the original Pilot Station people. C44617 Population Group Pilot Station C1553251 Pilot_Station Pilot Station Pilot Station A person having origins in the original Pitkas Point people. C44618 Population Group Pitkas Point C1553252 Pitkas_Point Pitkas Point Pitkas Point A person having origins in the original Portage Creek people. C44619 Population Group Portage Creek C1553254 Portage_Creek Portage Creek Portage Creek A person having origins in the original Quinhagak people. C44620 Population Group Quinhagak C1553255 Quinhagak Quinhagak Quinhagak A person having origins in the original Red Devil people. C44621 Population Group Red Devil C1553256 Red_Devil Red Devil Red Devil A person having origins in the original Scammon Bay people. C44623 Population Group Scammon Bay C1553258 Scammon_Bay Scammon Bay Scammon Bay A person having origins in the original Sheldon's Point people. C44624 Population Group Sheldon's Point C1553259 Sheldon_s_Point Sheldon's Point Sheldon's Point A person having origins in the original Sleetmute people. C44625 Population Group Sleetmute C1553260 Sleetmute Sleetmute Sleetmute A person having origins in the original Stebbins people. C44626 Population Group Stebbins C1553261 Stebbins Stebbins Stebbins A person having origins in the original Togiak people. C44627 Population Group Togiak C1553262 Togiak Togiak Togiak A person having origins in the original Toksook people. C44628 Population Group Toksook C1553263 Toksook Toksook Toksook A person having origins in the original Tulukskak people. C44629 Population Group Tulukskak C1553264 Tulukskak Tulukskak Tulukskak A person having origins in the original Tuntutuliak people. C44630 Population Group Tuntutuliak C1553265 Tuntutuliak Tuntutuliak Tuntutuliak A person having origins in the original Tununak people. C44631 Population Group Tununak C1553266 Tununak Tununak Tununak A person having origins in the original Twin Hills people. C44632 Population Group Twin Hills C1553267 Twin_Hills Twin Hills Twin Hills A person having origins in the original Georgetown Yupik people. C44633 Population Group Georgetown Yupik C1553268 Georgetown Georgetown Georgetown (Yupik-Eskimo) Georgetown Yupik Georgetown Yupik A person having origins in the original Umkumiate people. C44635 Population Group Umkumiate C1553270 Umkumiate Umkumiate Umkumiate A person having origins in the original Akutan people. C44636 Population Group Akutan C1553302 Akutan Akutan Akutan A person having origins in the original Aleut Corporation people. C44637 Population Group Aleut Corporation C1553303 Aleut_Corporation Aleut Corporation Aleut Corporation A person having origins in the original Aleutian Islander people. C44638 Population Group Aleutian Islander C1553305 Aleutian_Islander Aleutian Islander Aleutian Islander A person having origins in the original Atka people. C44639 Population Group Atka C1553306 Atka Atka Atka A person having origins in the original Belkofski people. C44640 Population Group Belkofski C1553307 Belkofski Belkofski Belkofski A person having origins in the original Chignik Lagoon people. C44641 Population Group Chignik Lagoon C1553308 Chignik_Lagoon Chignik Lagoon Chignik Lagoon A person having origins in the original King Cove people. C44642 Population Group King Cove C1553309 King_Cove King Cove King Cove A person having origins in the original False Pass people. C44643 Population Group False Pass C1553310 False_Pass False Pass False Pass A person having origins in the original Nelson Lagoon people. C44644 Population Group Nelson Lagoon C1553311 Nelson_Lagoon Nelson Lagoon Nelson Lagoon A person having origins in the original Nikolski people. C44645 Population Group Nikolski C1553312 Nikolski Nikolski Nikolski A person having origins in the original Pauloff Harbor people. C44646 Population Group Pauloff Harbor C1553313 Pauloff_Harbor Pauloff Harbor Pauloff Harbor A person having origins in the original Qagan Toyagungin people. C44647 Population Group Qagan Toyagungin C1553314 Qagan_Toyagungin Qagan Toyagungin Qagan Toyagungin A person having origins in the original Qawalangin people. C44648 Population Group Qawalangin C1553315 Qawalangin Qawalangin Qawalangin A person having origins in the original Sand Point people. C44651 Population Group Sand Point C1553318 Sand_Point Sand Point Sand Point A person having origins in the original South Naknek people. C44652 Population Group South Naknek C1553319 South_Naknek South Naknek South Naknek A person having origins in the original Unalaska people. C44653 Population Group Unalaska C1553320 Unalaska Unalaska Unalaska A person having origins in the original Unga people. C44654 Population Group Unga C1553321 Unga Unga Unga A person having origins in the original Chignik people. C44655 Population Group Chignik C1553274 Chignik Chignik Chignik A person having origins in the original Chignik Lake people. C44656 Population Group Chignik Lake C1553275 Chignik_Lake Chignik Lake Chignik Lake A person having origins in the original Egegik people. C44657 Population Group Egegik C1553276 Egegik Egegik Egegik A person having origins in the original Igiugig people. C44658 Population Group Igiugig C1553277 Igiugig Igiugig Igiugig A person having origins in the original Ivanof Bay people. C44659 Population Group Ivanof Bay C1553278 Ivanof_Bay Ivanof Bay Ivanof Bay A person having origins in the original King Salmon people. C44660 Population Group King Salmon C1553279 King_Salmon King Salmon King Salmon A person having origins in the original Kokhanok people. C44661 Population Group Kokhanok C1553280 Kokhanok Kokhanok Kokhanok A person having origins in the original Perryville people. C44662 Population Group Perryville C1553281 Perryville Perryville Perryville A person having origins in the original Pilot Point people. C44663 Population Group Pilot Point C1553282 Pilot_Point Pilot Point Pilot Point A person having origins in the original Port Heiden people. C44664 Population Group Port Heiden C1553283 Port_Heiden Port Heiden Port Heiden A person having origins in the original Ambler people. C44665 Population Group Ambler C1551796 Ambler Ambler Ambler A person having origins in the original Anaktuvuk people. C44666 Population Group Anaktuvuk C1551797 Anaktuvuk Anaktuvuk Anaktuvuk A person having origins in the original Anaktuvuk Pass people. C44667 Population Group Anaktuvuk Pass C1551798 Anaktuvuk_Pass Anaktuvuk Pass Anaktuvuk Pass A person having origins in the original Arctic Slope Inupiat people. C44668 Population Group Arctic Slope Inupiat C1551799 Arctic_Slope_Inupiat Arctic Slope Inupiat Arctic Slope Inupiat A person having origins in the original Arctic Slope Corporation people. C44669 Population Group Arctic Slope Corporation C1551800 Arctic_Slope_Corporation Arctic Slope Corporation Arctic Slope Corporation A person having origins in the original Atqasuk people. C44670 Population Group Atqasuk C1551801 Atqasuk Atqasuk Atqasuk A person having origins in the original Barrow people. C44671 Population Group Barrow C1551802 Barrow Barrow Barrow A person having origins in the original Bering Straits Inupiat people. C44672 Population Group Bering Straits Inupiat C1551803 Bering_Straits_Inupiat Bering Straits Inupiat Bering Straits Inupiat A person having origins in the original Brevig Mission people. C44673 Population Group Brevig Mission C1551804 Brevig_Mission Brevig Mission Brevig Mission A person having origins in the original Buckland people. C44674 Population Group Buckland C1551805 Buckland Buckland Buckland A person having origins in the original Chinik people. C44675 Population Group Chinik C1551806 Chinik Chinik Chinik A person having origins in the original Council people. C44676 Population Group Council C1551807 Council Council Council A person having origins in the original Deering people. C44677 Population Group Deering C1551808 Deering Deering Deering A person having origins in the original Elim people. C44678 Population Group Elim C1551809 Elim Elim Elim A person having origins in the original Golovin people. C44679 Population Group Golovin C1551810 Golovin Golovin Golovin A person having origins in the original Inalik Diamede people. C44680 Population Group Inalik Diamede C1551811 Inalik_Diamede Inalik Diamede Inalik Diomede Inalik Diamede A person having origins in the original Inupiaq people. C44681 Population Group Inupiaq C1551812 Inupiaq Inupiaq Inupiaq A person having origins in the original Kaktovik people. C44682 Population Group Kaktovik C1551813 Kaktovik Kaktovik Kaktovik A person having origins in the original Kawerak people. C44683 Population Group Kawerak C1551814 Kawerak Kawerak Kawerak A person having origins in the original Kiana people. C44684 Population Group Kiana C1551815 Kiana Kiana Kiana A person having origins in the original Kivalina people. C44685 Population Group Kivalina C1551816 Kivalina Kivalina Kivalina A person having origins in the original Kobuk people. C44686 Population Group Kobuk C1551817 Kobuk Kobuk Kobuk A person having origins in the original Kotzebue people. C44687 Population Group Kotzebue C1551818 Kotzebue Kotzebue Kotzebue A person having origins in the original Koyuk people. C44688 Population Group Koyuk C1551819 Koyuk Koyuk Koyuk A person having origins in the original Kwiguk people. C44689 Population Group Kwiguk C1551820 Kwiguk Kwiguk Kwiguk A person having origins in the original Mauneluk Inupiat people. C44690 Population Group Mauneluk Inupiat C1551821 Mauneluk_Inupiat Mauneluk Inupiat Mauneluk Inupiat A person having origins in the original Nana Inupiat people. C44691 Population Group Nana Inupiat C1551822 Nana_Inupiat Nana Inupiat Nana Iñupiat Nana Inupiat A person having origins in the original Noatak people. C44692 Population Group Noatak C1551823 Noatak Noatak Noatak A person having origins in the original Nome people. C44693 Population Group Nome C1551824 Nome Nome Nome A person having origins in the original Noorvik people. C44694 Population Group Noorvik C1551825 Noorvik Noorvik Noorvik A person having origins in the original Nuiqsut people. C44695 Population Group Nuiqsut C1551826 Nuiqsut Nuiqsut Nuiqsut A person having origins in the original Point Hope people. C44696 Population Group Point Hope C1551827 Point_Hope Point Hope Point Hope A person having origins in the original Point Lay people. C44697 Population Group Point Lay C1551828 Point_Lay Point Lay Point Lay A person having origins in the original Selawik people. C44698 Population Group Selawik C1551829 Selawik Selawik Selawik A person having origins in the original Shaktoolik people. C44699 Population Group Shaktoolik C1551830 Shaktoolik Shaktoolik Shaktoolik A person having origins in the original Shishmaref people. C44700 Population Group Shishmaref C1551831 Shishmaref Shishmaref Shishmaref A person having origins in the original Shungnak people. C44701 Population Group Shungnak C1551832 Shungnak Shungnak Shungnak A person having origins in the original Solomon people. C44702 Population Group Solomon C1551833 Solomon Solomon Solomon A person having origins in the original Teller people. C44703 Population Group Teller C1551834 Teller Teller Teller A person having origins in the original Unalakleet people. C44704 Population Group Unalakleet C1551835 Unalakleet Unalakleet Unalakleet A person having origins in the original Wainwright people. C44705 Population Group Wainwright C1551836 Wainwright Wainwright Wainwright A person having origins in the original Wales people. C44706 Population Group Wales C1551837 Wales Wales Wales A person having origins in the original White Mountain people. C44707 Population Group White Mountain C1551838 White_Mountain White Mountain White Mountain A person having origins in the original White Mountain Inupiat people. C44708 Population Group White Mountain Inupiat C1551839 White_Mountain_Inupiat White Mountain Inupiat White Mountain Inupiat A person having origins in the original Mary's Igloo people. C44709 Population Group Mary's Igloo C1551840 Mary_s_Igloo Mary's Igloo Mary's Igloo A person having origins in the original Angoon people. C44710 Population Group Angoon C1551772 Angoon Angoon Angoon A person having origins in the original Central Council of Tlingit and Haida Tribes people. C44711 Population Group Central Council of Tlingit and Haida Tribes C1551773 Central_Council_of_Tlingit_and_Haida_Tribes Central Council of Tlingit and Haida Tribes Central Council of Tlingit and Haida Tribes A person having origins in the original Chilkat people. C44712 Population Group Chilkat C1551774 Chilkat Chilkat Chilkat A person having origins in the original Chilkoot people. C44713 Population Group Chilkoot C1551775 Chilkoot Chilkoot Chilkoot A person having origins in the original Craig people. C44714 Population Group Craig C1551776 Craig Craig Craig A person having origins in the original Douglas people. C44715 Population Group Douglas C1551777 Douglas Douglas Douglas A person having origins in the original Haida people. C44716 Population Group Haida C0682117 Haida Haida Haida A person having origins in the original Hoonah people. C44717 Population Group Hoonah C1551778 Hoonah Hoonah Hoonah A person having origins in the original Hydaburg people. C44718 Population Group Hydaburg C1551779 Hydaburg Hydaburg Hydaburg A person having origins in the original Kake people. C44719 Population Group Kake C1551780 Kake Kake Kake A person having origins in the original Kasaan people. C44720 Population Group Kasaan C1551781 Kasaan Kasaan Kasaan A person having origins in the original Kenaitze people. C44721 Population Group Kenaitze C1551782 Kenaitze Kenaitze Kenaitze A person having origins in the original Ketchikan people. C44722 Population Group Ketchikan C1551783 Ketchikan Ketchikan Ketchikan A person having origins in the original Klawock people. C44723 Population Group Klawock C1551784 Klawock Klawock Klawock A person having origins in the original Pelican people. C44724 Population Group Pelican C1551785 Pelican Pelican Pelican A person having origins in the original Petersburg people. C44725 Population Group Petersburg C1551786 Petersburg Petersburg Petersburg A person having origins in the original Saxman people. C44726 Population Group Saxman C1551787 Saxman Saxman Saxman A person having origins in the original Sitka people. C44727 Population Group Sitka C1551788 Sitka Sitka Sitka A person having origins in the original Tenakee Springs people. C44728 Population Group Tenakee Springs C1551789 Tenakee_Springs Tenakee Springs Tenakee Springs A person having origins in the original Tlingit people. C44729 Population Group Tlingit C0682118 Tlingit Tlingit Tlingit A person having origins in the original Wrangell people. C44730 Population Group Wrangell C1551790 Wrangell Wrangell Wrangell A person having origins in the original Yakutat people. C44731 Population Group Yakutat C1551791 Yakutat Yakutat Yakutat A person having origins in the original Ahtna people. C44732 Population Group Ahtna C1551700 Ahtna Ahtna Ahtna A person having origins in the original Alatna people. C44733 Population Group Alatna C1551701 Alatna Alatna Alatna A person having origins in the original Alexander people. C44734 Population Group Alexander C1551702 Alexander Alexander Alexander A person having origins in the original Allakaket people. C44735 Population Group Allakaket C1551703 Allakaket Allakaket Allakaket A person having origins in the original Alanvik people. C44736 Population Group Alanvik C1551704 Alanvik Alanvik Alanvik A person having origins in the original Anvik people. C44737 Population Group Anvik C1551705 Anvik Anvik Anvik A person having origins in the original Arctic people. C44738 Population Group Arctic CL337306 Arctic Arctic Arctic A person having origins in the original Beaver people. C44739 Population Group Beaver C1551707 Beaver Beaver Beaver A person having origins in the original Birch Creek people. C44740 Population Group Birch Creek C1551708 Birch_Creek Birch Creek Birch Creek A person having origins in the original Cantwell people. C44741 Population Group Cantwell C1551709 Cantwell Cantwell Cantwell A person having origins in the original Chalkyitsik people. C44742 Population Group Chalkyitsik C1551710 Chalkyitsik Chalkyitsik Chalkyitsik A person having origins in the original Chickaloon people. C44743 Population Group Chickaloon C1551711 Chickaloon Chickaloon Chickaloon A person having origins in the original Chistochina people. C44744 Population Group Chistochina C1551712 Chistochina Chistochina Chistochina A person having origins in the original Chitina people. C44745 Population Group Chitina C1551713 Chitina Chitina Chitina A person having origins in the original Circle Tribe people. C44746 Population Group Circle Tribe C1551714 Circle_Tribe Circle Circle Tribe Circle Tribe A person having origins in the original Cook Inlet people. C44747 Population Group Cook Inlet C1551715 Cook_Inlet Cook Inlet Cook Inlet A person having origins in the original Copper Center people. C44748 Population Group Copper Center C1551716 Copper_Center Copper Center Copper Center A person having origins in the original Copper River people. C44749 Population Group Copper River C1551717 Copper_River Copper River Copper River A person having origins in the original Dot Lake people. C44750 Population Group Dot Lake C1551718 Dot_Lake Dot Lake Dot Lake A person having origins in the original Doyon people. C44751 Population Group Doyon C1551719 Doyon Doyon Doyon A person having origins in the original Eagle people. C44752 Population Group Eagle C1551720 Eagle Eagle Eagle A person having origins in the original Eklutna people. C44753 Population Group Eklutna C1551721 Eklutna Eklutna Eklutna A person having origins in the original Evansville people. C44754 Population Group Evansville C1551722 Evansville Evansville Evansville A person having origins in the original Fort Yukon people. C44755 Population Group Fort Yukon C1551723 Fort_Yukon Fort Yukon Fort Yukon A person having origins in the original Gakona people. C44756 Population Group Gakona C1551724 Gakona Gakona Gakona A person having origins in the original Galena people. C44757 Population Group Galena C1551725 Galena Galena Galena A person having origins in the original Grayling people. C44758 Population Group Grayling C5772503 Grayling Grayling Grayling A person having origins in the original Gulkana people. C44759 Population Group Gulkana C1551727 Gulkana Gulkana Gulkana A person having origins in the original Healy Lake people. C44760 Population Group Healy Lake C1551728 Healy_Lake Healy Lake Healy Lake A person having origins in the original Holy Cross people. C44761 Population Group Holy Cross C1551729 Holy_Cross Holy Cross Holy Cross A person having origins in the original Hughes people. C44762 Population Group Hughes C1551730 Hughes Hughes Hughes A person having origins in the original Huslia people. C44763 Population Group Huslia C1551731 Huslia Huslia Huslia A person having origins in the original Iliamna people. C44764 Population Group Iliamna C1551732 Iliamna Iliamna Iliamna A person having origins in the original Kaltag people. C44765 Population Group Kaltag C1551733 Kaltag Kaltag Kaltag A person having origins in the original Kluti Kaah people. C44766 Population Group Kluti Kaah C1551734 Kluti_Kaah Kluti Kaah Kluti Kaah A person having origins in the original Knik people. C44767 Population Group Knik C1551735 Knik Knik Knik A person having origins in the original Koyukuk people. C44768 Population Group Koyukuk C1551736 Koyukuk Koyukuk Koyukuk A person having origins in the original Lake Minchumina people. C44769 Population Group Lake Minchumina C1551737 Lake_Minchumina Lake Minchumina Lake Minchumina A person having origins in the original Lime people. C44770 Population Group Lime C1551738 Lime Lime Lime A person having origins in the original Mcgrath people. C44771 Population Group Mcgrath C1551739 Mcgrath Mcgrath Mcgrath A person having origins in the original Manley Hot Springs people. C44772 Population Group Manley Hot Springs C1551740 Manley_Hot_Springs Manley Hot Springs Manley Hot Springs A person having origins in the original Mentasta Lake people. C44773 Population Group Mentasta Lake C1551741 Mentasta_Lake Mentasta Lake Mentasta Lake A person having origins in the original Minto people. C44774 Population Group Minto C1551742 Minto Minto Minto A person having origins in the original Nenana people. C44775 Population Group Nenana C1551743 Nenana Nenana Nenana A person having origins in the original Nikolai people. C44776 Population Group Nikolai C1551744 Nikolai Nikolai Nikolai A person having origins in the original Ninilchik people. C44777 Population Group Ninilchik C1551745 Ninilchik Ninilchik Ninilchik A person having origins in the original Nondalton people. C44778 Population Group Nondalton C1551746 Nondalton Nondalton Nondalton A person having origins in the original Northway people. C44779 Population Group Northway C1551747 Northway Northway Northway A person having origins in the original Nulato people. C44780 Population Group Nulato C1551748 Nulato Nulato Nulato A person having origins in the original Pedro Bay people. C44781 Population Group Pedro Bay C1551749 Pedro_Bay Pedro Bay Pedro Bay A person having origins in the original Rampart people. C44782 Population Group Rampart C1551750 Rampart Rampart Rampart A person having origins in the original Ruby people. C44783 Population Group Ruby C1551751 Ruby Ruby Ruby A person having origins in the original Salamatof people. C44784 Population Group Salamatof C5709209 Salamatof Salamatof Salamatof A person having origins in the original Seldovia people. C44785 Population Group Seldovia C1551753 Seldovia Seldovia Seldovia A person having origins in the original Slana people. C44786 Population Group Slana C1551754 Slana Slana Slana A person having origins in the original Shageluk people. C44787 Population Group Shageluk C1551755 Shageluk Shageluk Shageluk A person having origins in the original Stevens people. C44788 Population Group Stevens C1551756 Stevens Stevens Stevens A person having origins in the original Stony River people. C44789 Population Group Stony River C1551757 Stony_River Stony River Stony River A person having origins in the original Takotna people. C44790 Population Group Takotna C1551758 Takotna Takotna Takotna A person having origins in the original Tanacross people. C44791 Population Group Tanacross C1551759 Tanacross Tanacross Tanacross A person having origins in the original Tanaina people. C44792 Population Group Tanaina C1551760 Tanaina Tanaina Tanaina A person having origins in the original Tanana people. C44793 Population Group Tanana C1551761 Tanana Tanana Tanana A person having origins in the original Tanana Chiefs people. C44794 Population Group Tanana Chiefs C1551762 Tanana_Chiefs Tanana Chiefs Tanana Chiefs A person having origins in the original Tazlina people. C44795 Population Group Tazlina C1551763 Tazlina Tazlina Tazlina A person having origins in the original Telida people. C44796 Population Group Telida C1551764 Telida Telida Telida A person having origins in the original Tetlin people. C44797 Population Group Tetlin C1551765 Tetlin Tetlin Tetlin A person having origins in the original Tok people. C44798 Population Group Tok C1551766 Tok Tok Tok A person having origins in the original Tyonek people. C44799 Population Group Tyonek C1551767 Tyonek Tyonek Tyonek A person having origins in the original Venetie people. C44800 Population Group Venetie C1551768 Venetie Venetie Venetie A person having origins in the original Wiseman people. C44801 Population Group Wiseman C1551769 Wiseman Wiseman Wiseman A person having origins in the original Duwamish people. C44802 Population Group Duwamish C1551540 Duwamish Duwamish Duwamish A person having origins in the original Kikiallus people. C44803 Population Group Kikiallus C1551541 Kikiallus Kikiallus Kikiallus A person having origins in the original Lower Skagit people. C44804 Population Group Lower Skagit C1551542 Lower_Skagit Lower Skagit Lower Skagit A person having origins in the original Muckleshoot people. C44805 Population Group Muckleshoot C1551543 Muckleshoot Muckleshoot Muckleshoot A person having origins in the original Nisqually people. C44806 Population Group Nisqually C1551544 Nisqually Nisqually Nisqually A person having origins in the original Nooksack people. C44807 Population Group Nooksack C1551545 Nooksack Nooksack Nooksack A person having origins in the original Port Madison people. C44808 Population Group Port Madison C1551546 Port_Madison Port Madison Port Madison A person having origins in the original Puyallup people. C44809 Population Group Puyallup C1551547 Puyallup Puyallup Puyallup A person having origins in the original Samish people. C44810 Population Group Samish C1551548 Samish Samish Samish A person having origins in the original Sauk-Suiattle people. C44811 Population Group Sauk-Suiattle C1551549 Sauk-Suiattle Sauk-Suiattle Sauk-Suiattle A person having origins in the original Skokomish people. C44812 Population Group Skokomish C1551550 Skokomish Skokomish Skokomish A person having origins in the original Skykomish people. C44813 Population Group Skykomish C1551551 Skykomish Skykomish Skykomish A person having origins in the original Snohomish people. C44814 Population Group Snohomish C1551552 Snohomish Snohomish Snohomish A person having origins in the original Snoqualmie people. C44815 Population Group Snoqualmie C1551553 Snoqualmie Snoqualmie Snoqualmie A person having origins in the original Squaxin Island people. C44816 Population Group Squaxin Island C1551554 Squaxin_Island Squaxin Island Squaxin Island A person having origins in the original Steilacoom people. C44817 Population Group Steilacoom C1551555 Steilacoom Steilacoom Steilacoom A person having origins in the original Stillaguamish people. C44818 Population Group Stillaguamish C1551556 Stillaguamish Stillaguamish Stillaguamish A person having origins in the original Suquamish people. C44819 Population Group Suquamish C1551557 Suquamish Suquamish Suquamish A person having origins in the original Swinomish people. C44820 Population Group Swinomish C1551558 Swinomish Swinomish Swinomish A person having origins in the original Tulalip people. C44821 Population Group Tulalip C1551559 Tulalip Tulalip Tulalip A person having origins in the original Upper Skagit people. C44822 Population Group Upper Skagit C1551560 Upper_Skagit Upper Skagit Upper Skagit A person having origins in the original Acoma people. C44823 Population Group Acoma C1551514 Acoma Acoma Acoma A person having origins in the original Arizona Tewa people. C44824 Population Group Arizona Tewa C1551515 Arizona_Tewa Arizona Tewa Arizona Tewa A person having origins in the original Cochiti people. C44825 Population Group Cochiti C1551516 Cochiti Cochiti Cochiti A person having origins in the original Hopi people. C44826 Population Group Hopi C0682111 Hopi Hopi Hopi A person having origins in the original Isleta people. C44827 Population Group Isleta C1551517 Isleta Isleta Isleta A person having origins in the original Jemez people. C44828 Population Group Jemez C1551518 Jemez Jemez Jemez A person having origins in the original Keres people. C44829 Population Group Keres C1551519 Keres Keres Keres A person having origins in the original Laguna people. C44830 Population Group Laguna C1551520 Laguna Laguna Laguna A person having origins in the original Nambe people. C44831 Population Group Nambe C1551521 Nambe Nambe Nambe A person having origins in the original Picuris people. C44832 Population Group Picuris C1551522 Picuris Picuris Picuris A person having origins in the original Piro people. C44833 Population Group Piro C1551523 Piro Piro Piro A person having origins in the original Pojoaque people. C44834 Population Group Pojoaque C1551524 Pojoaque Pojoaque Pojoaque A person having origins in the original San Felipe people. C44835 Population Group San Felipe C1551525 San_Felipe San Felipe San Felipe A person having origins in the original San Ildefonso people. C44836 Population Group San Ildefonso C1551526 San_Ildefonso San Ildefonso San Ildefonso A person having origins in the original San Juan Pueblo people. C44837 Population Group San Juan Pueblo C1551527 San_Juan_Pueblo San Juan Pueblo San Juan Pueblo A person having origins in the original San Juan De people. C44838 Population Group San Juan De C1551528 San_Juan_De San Juan De San Juan De A person having origins in the original San Juan people. C44839 Population Group San Juan C1551529 San_Juan San Juan San Juan A person having origins in the original Sandia people. C44840 Population Group Sandia C1551530 Sandia Sandia Sandia A person having origins in the original Santa Ana people. C44841 Population Group Santa Ana C1551531 Santa_Ana Santa Ana Santa Ana A person having origins in the original Santa Clara people. C44842 Population Group Santa Clara C1551532 Santa_Clara Santa Clara Santa Clara A person having origins in the original Santo Domingo people. C44843 Population Group Santo Domingo C1551533 Santo_Domingo Santo Domingo Santo Domingo A person having origins in the original Taos people. C44844 Population Group Taos C1551534 Taos Taos Taos A person having origins in the original Tesuque people. C44845 Population Group Tesuque C1551535 Tesuque Tesuque Tesuque A person having origins in the original Tewa people. C44846 Population Group Tewa C1551536 Tewa Tewa Tewa A person having origins in the original Tigua people. C44847 Population Group Tigua C1551537 Tigua Tigua Tigua A person having origins in the original Zia people. C44848 Population Group Zia C1554444 Zia Zia Zia A person having origins in the original Zuni people. C44849 Population Group Zuni C0682110 Zuni Zuni Zuñi Zuni A person having origins in the original Citzen Band Potawatomi people. C44850 Population Group Citzen Band Potawatomi C1551506 Citzen_Band_Potawatomi Citizen Band Potawatomi Citzen Band Potawatomi Citzen Band Potawatomi A person having origins in the original Forest County people. C44851 Population Group Forest County C1551507 Forest_County Forest County Forest County A person having origins in the original Hannahville people. C44852 Population Group Hannahville C1551508 Hannahville Hannahville Hannahville A person having origins in the original Huron Potawatomi people. C44853 Population Group Huron Potawatomi C1551509 Huron_Potawatomi Huron Potawatomi Huron Potawatomi A person having origins in the original Pokagon Potawatomi people. C44854 Population Group Pokagon Potawatomi C1551510 Pokagon_Potawatomi Pokagon Potawatomi Pokagon Potawatomi A person having origins in the original Prairie Band people. C44855 Population Group Prairie Band C1551511 Prairie_Band Prairie Band Prairie Band A person having origins in the original Wisconsin Potawatomi people. C44856 Population Group Wisconsin Potawatomi C1551512 Wisconsin_Potawatomi Wisconsin Potawatomi Wisconsin Potawatomi A person having origins in the original Central Pomo people. C44857 Population Group Central Pomo C1551494 Central_Pomo Central Pomo Central Pomo A person having origins in the original Dry Creek people. C44858 Population Group Dry Creek C1551495 Dry_Creek Dry Creek Dry Creek A person having origins in the original Eastern Pomo people. C44859 Population Group Eastern Pomo C1551496 Eastern_Pomo Eastern Pomo Eastern Pomo A person having origins in the original Kashia people. C44860 Population Group Kashia C1551497 Kashia Kashia Kashia A person having origins in the original Northern Pomo people. C44861 Population Group Northern Pomo C1551498 Northern_Pomo Northern Pomo Northern Pomo A person having origins in the original Scotts Valley people. C44862 Population Group Scotts Valley C1551499 Scotts_Valley Scotts Valley Scotts Valley A person having origins in the original Stonyford people. C44863 Population Group Stonyford C1551500 Stonyford Stonyford Stonyford A person having origins in the original Sulphur Bank people. C44864 Population Group Sulphur Bank C1551501 Sulphur_Bank Sulphur Bank Sulphur Bank A person having origins in the original Cayuga people. C44865 Population Group Cayuga C1555234 Cayuga Cayuga Cayuga A person having origins in the original Mohawk people. C44866 Population Group Mohawk C0682099 Mohawk Mohawk A person having origins in the original Oneida people. C44867 Population Group Oneida C1555235 Oneida Oneida Oneida A person having origins in the original Onondaga people. C44868 Population Group Onondaga C1555236 Onondaga Onondaga Onondaga A person having origins in the original Seneca people. C44869 Population Group Seneca C1555237 Seneca Seneca Seneca A person having origins in the original Seneca Nation people. C44870 Population Group Seneca Nation C1555238 Seneca_Nation Seneca Nation Seneca Nation A person having origins in the original Seneca-Cayuga people. C44871 Population Group Seneca-Cayuga C1555239 Seneca-Cayuga Seneca-Cayuga Seneca-Cayuga A person having origins in the original Tonawanda Seneca people. C44872 Population Group Tonawanda Seneca C1555240 Tonawanda_Seneca Tonawanda Seneca Tonawanda Seneca A person having origins in the original Tuscarora people. C44873 Population Group Tuscarora C1555241 Tuscarora Tuscarora Tuscarora A person having origins in the original Wyandotte people. C44874 Population Group Wyandotte C1555242 Wyandotte Wyandotte Wyandotte A person having origins in the original Attacapa people. C44875 Population Group Attacapa C1555199 Attacapa Attacapa Attacapa A person having origins in the original Biloxi people. C44876 Population Group Biloxi C1555200 Biloxi Biloxi Biloxi A person having origins in the original Moor people. C44877 Population Group Moor C1555202 Moor Moor Moor A person having origins in the original Nansemond people. C44878 Population Group Nansemond C1555203 Nansemond Nansemond A person having origins in the original Natchez people. C44879 Population Group Natchez C1555204 Natchez Natchez Natchez A person having origins in the original Nausu Waiwash people. C44880 Population Group Nausu Waiwash C1555205 Nausu_Waiwash Nausu Waiwash Nausu Waiwash A person having origins in the original Nipmuc people. C44881 Population Group Nipmuc C1555206 Nipmuc Nipmuc Nipmuc A person having origins in the original Paugussett people. C44882 Population Group Paugussett C1555207 Paugussett Paugussett Paugussett A person having origins in the original Pocomoke Acohonock people. C44883 Population Group Pocomoke Acohonock C1555208 Pocomoke_Acohonock Pocomoke Acohonock Pocomoke Acohonock A person having origins in the original Southeastern Indians people. C44884 Population Group Southeastern Indians C1555209 Southeastern_Indians Southeastern Indians Southeastern Indians A person having origins in the original Susquehanock people. C44885 Population Group Susquehanock C1555210 Susquehanock Susquehanock Susquehanock A person having origins in the original Tunica Biloxi people. C44886 Population Group Tunica Biloxi C1555211 Tunica_Biloxi Tunica Biloxi Tunica Biloxi A person having origins in the original Waccamaw Siousan people. C44887 Population Group Waccamaw-Siousan C1555212 Waccamaw_Siousan Waccamaw Siousan Waccamaw-Siousan Waccamaw-Siousan A person having origins in the original Wicomico people. C44888 Population Group Wicomico C1555213 Wicomico Wicomico Wicomico A person having origins in the original Eastern Delaware people. C44889 Population Group Eastern Delaware C1555183 Eastern_Delaware Eastern Delaware Eastern Delaware A person having origins in the original Lenni-Lenape people. C44890 Population Group Lenni-Lenape C1555184 Lenni_Lenape Lenni Lenape Lenni-Lenape Lenni-Lenape A person having origins in the original Munsee people. C44891 Population Group Munsee C1555185 Munsee Munsee Munsee A person having origins in the original Oklahoma Delaware people. C44892 Population Group Oklahoma Delaware C1555186 Oklahoma_Delaware Oklahoma Delaware Oklahoma Delaware A person having origins in the original Rampough Mountain people. C44893 Population Group Rampough Mountain C1555187 Rampough_Mountain Rampough Mountain Rampough Mountain A person having origins in the original Sand Hill people. C44894 Population Group Sand Hill C1555188 Sand_Hill Sand Hill Sand Hill A person having origins in the original Alabama Creek people. C44895 Population Group Alabama Creek C1555166 Alabama_Creek Alabama Creek Alabama Creek A person having origins in the original Alabama Quassarte people. C44896 Population Group Alabama Quassarte C1555167 Alabama_Quassarte Alabama Quassarte Alabama Quassarte A person having origins in the original Eastern Creek people. C44897 Population Group Eastern Creek C1555168 Eastern_Creek Eastern Creek Eastern Creek A person having origins in the original Eastern Muscogee people. C44898 Population Group Eastern Muscogee C1555169 Eastern_Muscogee Eastern Muscogee Eastern Muscogee A person having origins in the original Kialegee people. C44899 Population Group Kialegee C1555170 Kialegee Kialegee Kialegee A person having origins in the original Lower Muscogee people. C44900 Population Group Lower Muscogee C1555171 Lower_Muscogee Lower Muscogee Lower Muscogee A person having origins in the original Machis Lower Creek Indian people. C44901 Population Group Machis Lower Creek Indian C1555172 Machis_Lower_Creek_Indian Machis Lower Creek Indian Machis Lower Creek Indian A person having origins in the original Poarch Band people. C44902 Population Group Poarch Band C1555173 Poarch_Band Poarch Band Poarch Band A person having origins in the original Principal Creek Indian Nation people. C44903 Population Group Principal Creek Indian Nation C1555174 Principal_Creek_Indian_Nation Principal Creek Indian Nation Principal Creek Indian Nation A person having origins in the original Star Clan of Muscogee Creeks people. C44904 Population Group Star Clan of Muscogee Creeks C1555175 Star_Clan_of_Muscogee_Creeks Star Clan of Muscogee Creeks Star Clan of Muscogee Creeks A person having origins in the original Thlopthlocco people. C44905 Population Group Thlopthlocco C1555176 Thlopthlocco Thlopthlocco Thlopthlocco A person having origins in the original Tuckabachee people. C44906 Population Group Tuckabachee C1555177 Tuckabachee Tuckabachee Tuckabachee A person having origins in the original Bad River people. C44907 Population Group Bad River C1555119 Bad_River Bad River Bad River A person having origins in the original Bay Mills Chippewa people. C44908 Population Group Bay Mills Chippewa C1555120 Bay_Mills_Chippewa Bay Mills Chippewa Bay Mills Chippewa A person having origins in the original Bois Forte people. C44909 Population Group Bois Forte C1555121 Bois_Forte Bois Forte Nett Lake Bois Forte A person having origins in the original Burt Lake Chippewa people. C44910 Population Group Burt Lake Chippewa C1555122 Burt_Lake_Chippewa Burt Lake Chippewa Burt Lake Chippewa A person having origins in the original Fond du Lac people. C44911 Population Group Fond du Lac C1555123 Fond_du_Lac Fond du Lac Fond du Lac A person having origins in the original Grand Portage people. C44912 Population Group Grand Portage C5772609 Grand_Portage Grand Portage Grand Portage A person having origins in the original Grand Traverse Band of Ottawa/Chippewa people. C44913 Population Group Grand Traverse Band of Ottawa/Chippewa CL1929240 Grand_Traverse_Band_of_Ottawa_Chippewa Grand Traverse Band of Ottawa/Chippewa Grand Traverse Band of Ottawa/Chippewa A person having origins in the original Keweenaw people. C44914 Population Group Keweenaw C1555126 Keweenaw Keweenaw Keweenaw A person having origins in the original Lac Courte Oreilles people. C44915 Population Group Lac Courte Oreilles C1555127 Lac_Courte_Oreilles Lac Courte Oreilles Lac Courte Oreilles A person having origins in the original Lac du Flambeau people. C44916 Population Group Lac du Flambeau C1555128 Lac_du_Flambeau Lac du Flambeau Lac du Flambeau A person having origins in the original Lac Vieux Desert Chippewa people. C44917 Population Group Lac Vieux Desert Chippewa CL1929239 Lac_Vieux_Desert_Chippewa Lac Vieux Desert Chippewa Lac Vieux Desert Chippewa A person having origins in the original Lake Superior people. C44918 Population Group Lake Superior C1555130 Lake_Superior Lake Superior Lake Superior A person having origins in the original Leech Lake people. C44919 Population Group Leech Lake C1555131 Leech_Lake Leech Lake Leech Lake A person having origins in the original Little Shell Chippewa people. C44920 Population Group Little Shell Chippewa C1555132 Little_Shell_Chippewa Little Shell Chippewa Little Shell Chippewa A person having origins in the original Mille Lacs people. C44921 Population Group Mille Lacs C1555133 Mille_Lacs Mille Lacs Mille Lacs A person having origins in the original Minnesota Chippewa people. C44922 Population Group Minnesota Chippewa C1555134 Minnesota_Chippewa Minnesota Chippewa Minnesota Chippewa A person having origins in the original Ontonagon people. C44923 Population Group Ontonagon C1555135 Ontonagon Ontonagon Ontonagon A person having origins in the original Red Cliff Chippewa people. C44924 Population Group Red Cliff Chippewa C1555136 Red_Cliff_Chippewa Red Cliff Chippewa Red Cliff Chippewa A person having origins in the original Red Lake Chippewa people. C44925 Population Group Red Lake Chippewa C1555137 Red_Lake_Chippewa Red Lake Chippewa Red Lake Chippewa A person having origins in the original Saginaw Chippewa people. C44926 Population Group Saginaw Chippewa C1555138 Saginaw_Chippewa Saginaw Chippewa Saginaw Chippewa A person having origins in the original Sokoagon Chippewa people. C44929 Population Group Sokoagon Chippewa C1555141 Sokoagon_Chippewa Sokoagon Chippewa Sokoagon Chippewa A person having origins in the original Turtle Mountain people. C44930 Population Group Turtle Mountain C1555142 Turtle_Mountain Turtle Mountain Turtle Mountain A person having origins in the original White Earth people. C44931 Population Group White Earth C1555143 White_Earth White Earth White Earth A person having origins in the original Clatsop people. C44932 Population Group Clatsop C1555112 Clatsop Clatsop Clatsop A person having origins in the original Kathlamet people. C44934 Population Group Kathlamet C1555114 Kathlamet Kathlamet Kathlamet A person having origins in the original Upper Chinook people. C44935 Population Group Upper Chinook C1555115 Upper_Chinook Upper Chinook Upper Chinook A person having origins in the original Wakiakum Chinook people. C44936 Population Group Wakiakum Chinook C1555116 Wakiakum_Chinook Wakiakum Chinook Wakiakum Chinook A person having origins in the original Willapa Chinook people. C44937 Population Group Willapa Chinook C1555117 Willapa_Chinook Willapa Chinook Willapa Chinook A person having origins in the original Wishram people. C44938 Population Group Wishram C1555118 Wishram Wishram Wishram A person having origins in the original Cherokee Alabama people. C44939 Population Group Cherokee Alabama C1555094 Cherokee_Alabama Cherokee Alabama Cherokee Alabama A person having origins in the original Cherokees of Northeast Alabama people. C44940 Population Group Cherokees of Northeast Alabama C1555095 Cherokees_of_Northeast_Alabama Cherokees of Northeast Alabama Cherokees of Northeast Alabama A person having origins in the original Cherokees of Southeast Alabama people. C44941 Population Group Cherokees of Southeast Alabama C1555096 Cherokees_of_Southeast_Alabama Cherokees of Southeast Alabama Cherokees of Southeast Alabama A person having origins in the original Eastern Cherokee people. C44942 Population Group Eastern Cherokee C1555097 Eastern_Cherokee Eastern Cherokee Eastern Cherokee A person having origins in the original Echota Cherokee people. C44943 Population Group Echota Cherokee C1555098 Echota_Cherokee Echota Cherokee Echota Cherokee A person having origins in the original Etowah Cherokee people. C44944 Population Group Etowah Cherokee C1555099 Etowah_Cherokee Etowah Cherokee Etowah Cherokee A person having origins in the original Tuscola people. C44946 Population Group Tuscola C1555101 Tuscola Tuscola Tuscola A person having origins in the original United Keetowah Band of Cherokee people. C44947 Population Group United Keetowah Band of Cherokee C1555102 United_Keetowah_Band_of_Cherokee United Keetowah Band of Cherokee United Keetowah Band of Cherokee A person having origins in the original Western Cherokee people. C44948 Population Group Western Cherokee C1555103 Western_Cherokee Western Cherokee Western Cherokee A person having origins in the original Canadian Indian people. C44949 Population Group Canadian Indian C1555084 CDISC The native people of Canada. Canadian_Indian CANADIAN INDIAN Canadian Indian Canadian Indian A person having origins in the original Central American Indian people. C44950 Population Group Central American Indian C0021207 CDISC The native people of Central America. Central_American_Indian CENTRAL AMERICAN INDIAN Central American Indian Central American Indian A person having origins in the original French American Indian people. C44951 Population Group French American Indian C1555085 French_American_Indian French American Indian French American Indian A person having origins in the original Mexican American Indian people. C44952 Population Group Mexican American Indian C1555086 Mexican_American_Indian Indigenous Mexican American Mexican American Indian Mexican American Indian A person having origins in the original South American Indian people. C44953 Population Group South American Indian C1610165 CDISC The native people of South America. South_American_Indian SOUTH AMERICAN INDIAN South American Indian South American Indian A person having origins in the original Spanish American Indian people. C44954 Population Group Spanish American Indian C1555087 Spanish_American_Indian Spanish American Indian Spanish American Indian A person having origins in the original Aleut people. C45170 Population Group Aleut C0085766 Aleut Aleut Aleut A person having origins in the original Columbia River Chinook people. C45218 Population Group Columbia River Chinook C1555113 Columbia_River_Chinook Columbia River Chinook Columbia River Chinook A person having origins in the original Northern Cherokee people. C45220 Population Group Northern Cherokee C1555100 Northern_Cherokee Northern Cherokee Northern Cherokee A person having origins in the original Platinum people. C45221 Population Group Platinum People C1553253 Platinum_Eskimo Platinum Platinum People Platinum People A person having origins in the original Delaware people. C45222 Population Group Delaware C1555182 Delaware_Indian Deleware_Indian Delaware Delaware A person having origins in the original Sault Ste. Marie Chippewa people. C45223 Population Group Sault Ste. Marie Chippewa C1555140 Sault_Ste_Marie_Chippewa Sault Ste. Marie Chippewa Sault Ste. Marie Chippewa A person having origins in the original St. Croix Chippewa people. C45224 Population Group St. Croix Chippewa C1555139 St_Croix_Chippewa St. Croix Chippewa St. Croix Chippewa A person having origins in the original St. George people. C45225 Population Group St. George C1553316 St_George St. George St. George A person having origins in the original St. Paul people. C45226 Population Group St. Paul C1553317 St_Paul St. Paul St. Paul A person having origins in the original St. Mary's people. C45227 Population Group St. Mary's C1553269 St_Marys St. Mary's St. Mary's A person having origins in the original St. Michael people. C45228 Population Group St. Michael C1553257 St_Michael St. Michael St. Michael A person having origins in the original Yavapai people. C45229 Population Group Yavapai C1551696 Yavapai Yavapai Yavapai The mean pressure of the blood within the arterial circulation. The arterial pressure may be directly measured by insertion of an intra-arterial catheter connected to a transducer. The mean arterial pressure (MAP) can be calculated by subsequent analysis of the waveform. MAP can be approximated without an invasive procedure using the following formula: diastolic pressure plus 1/3 of the pulse pressure, where pulse pressure is systolic pressure - diastolic pressure. C49679 Quantitative Concept Mean Arterial Pressure C0428886 CDISC The mean pressure of the blood within the arterial circulation. Mean_Arterial_Pressure MAP Mean Arterial Pressure Mean Arterial Pressure Employed for a standard number of hours of working time, at least 50% or 20 hours per week. C52658 Qualitative Concept Full Time Employment C0682295 ACC/AHA CDISC Employed for a standard number of hours of working time, at least 50% or 20 h/wk. Employment involving the standard or customary working time. Full_Time_Employment FULL-TIME Full Time Full Time Employment Full-Time Full-time Full-time Employment Working full time Working full-time for pay Full Time Employment C53333 Quantitative Concept Socioeconomic Indicator C1711331 Socioeconomic_Indicator Socioeconomic Indicator Socioeconomic Indicator C53334 Quantitative Concept Median Income C1708953 Median_Income Median Income Median Income A demographic parameter indicating the average amount of schooling in a particular population or/and during a particular period of time. C53335 Quantitative Concept Average Education Level C1711249 Average_Education_Level Average Education Level Average Education Level The fraction of a population whose income is less than that considered sufficient for survival. C53336 Quantitative Concept Percent Below Poverty C1711336 Percent_Below_Poverty Percent Below Poverty Percent Below Poverty C53337 Quantitative Concept Percent with Medical Insurance C1709502 Percent_with_Medical_Insurance Percent with Medical Insurance Percent with Medical Insurance The number of individuals per unit geographic area. C53338 Quantitative Concept Population Density CL370089 Population_Density Population Density Population Density C53339 Quantitative Concept Housing Age C1708388 Housing_Age Housing Age Housing Age C53340 Quantitative Concept Percent Home Ownership C1709498 Percent_Home_Ownership Percent Home Ownership Percent Home Ownership C53341 Quantitative Concept Percent Single Parent Households C1709499 Percent_Single_Parent_Households Percent Single Parent Households Percent Single Parent Households The fraction of a population who's members were born outside of the country. C53342 Quantitative Concept Percent Foreign Born C1709497 Percent_Foreign_Born Percent Foreign Born Percent Foreign Born The fraction of a population that does not speak English. C53343 Quantitative Concept Percent non-English Speakers C1709501 Percent_non-English_Speakers Percent non-English Speakers Percent non-English Speakers The pressure of the circulating blood against the walls of the blood vessels. C54706 Clinical Attribute Blood Pressure Blood Pressure C0005823 CTRP NICHD The force of circulating blood on the walls of the arteries. Blood pressure is taken using two measurements: systolic (measured when the heart beats, when blood pressure is at its highest) and diastolic (measured between heart beats, when blood pressure is at its lowest). Blood pressure is written with the systolic blood pressure first, followed by the diastolic blood pressure (for example 120/80). Blood_Pressure BP Blood Pressure blood pressure Blood Pressure A person who has never smoked at the time of the interview or has smoked less than 100 cigarettes in their life. C65108 Organism Attribute Never Smoker Never Smoker C0425293 ACC/AHA CTRP GDC Never_Smoker Lifelong Non-Smoker Lifelong Non-Smoker Never Smoked Never Smoker Never smoker Never Smoker Having ancestors of several or various races. C67109 Population Group Multiracial C1881928 PCDC SeroNet Multiracial Multiracial Multiracial A person living in the United States of Mexican, Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans. C67111 Population Group Multiple Hispanic C1881927 Multiple_Hispanic Multiple Hispanic Multiple Hispanic A person of Puerto Rican culture or origin, regardless of race. C67112 Population Group Puerto Rican C0034043 CDISC FDA A person of Puerto Rican descent. Puerto_Rican PUERTO RICAN Puerto Rican Puertorican Puerto Rican Denotes a person from or of Mexico. C67113 Population Group Mexican C0240339 CDISC A person of Mexican descent. Mexican MEXICAN Mexican Mexicano Mexican Denotes an american citizen of Mexican descent. C67114 Population Group Mexican American C0025884 CDISC A person of Mexican and American descent. Mexican_American MEXICAN AMERICAN Mexican American Mexican American Denotes a person from or of Cuba or an American citizen of Cuban descent. C67115 Population Group Cuban or Cuban American C0010436 CDISC A person of Cuban and American descent. Cuban_or_Cuban_American CUBAN AMERICAN Cuban or Cuban American Cuban or Cuban American Denotes the inhabitants of the Dominican Republic, a person from there, or their descendants elsewhere. C67117 Population Group Dominican CL388698 CDISC A person having origins in any of the original peoples of the Dominican Republic. Dominican_Republican DOMINICAN Dominican Dominican Denotes a person from the area between north and south America including persons from Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama, and the Panama Canal zone. C67118 Population Group Central American C0238914 CDISC A person of Central American descent. Cental_American CENTRAL AMERICAN Central American Central American Denotes a person from Spain or of Spanish descent. C67120 Population Group Spanish C3161473 CDISC A person from Spain or of Spanish descent. Spanish SPANISH Spaniard Spanish Spanish Indicates that a person has never attended an educational program or formal schooling. C67122 Organism Attribute No Formal Schooling C0557286 Never_Attended Never Attended Never Attended School No Formal Schooling No Formal Schooling Indicates that 1st grade is the highest level of educational achievement. C67123 Organism Attribute 1st Grade Completion C1883619 _1st_Grade 1st Grade 1st Grade Completion Completed 1st Grade 1st Grade Completion Indicates that 2nd grade is the highest level of educational achievement. C67124 Organism Attribute 2nd Grade Completion C1883622 _2nd_Grade 2nd Grade 2nd Grade Completion Completed 2nd Grade 2nd Grade Completion Indicates that 3rd grade is the highest level of educational achievement. C67125 Organism Attribute 3rd Grade Completion C1883635 _3rd_Grade 3rd Grade 3rd Grade Completion Completed 3rd Grade 3rd Grade Completion Indicates that 4th grade is the highest level of educational achievement. C67126 Organism Attribute 4th Grade Completion C1883642 _4th_Grade 4th Grade 4th Grade Completion Completed 4th Grade 4th Grade Completion Indicates that 5th grade is the highest level of educational achievement. C67127 Organism Attribute 5th Grade Completion C1883646 _5th_Grade 5th Grade 5th Grade Completion Completed 5th Grade 5th Grade Completion Indicates that 6th grade is the highest level of educational achievement. C67128 Organism Attribute 6th Grade Completion C1883649 _6th_Grade 6th Grade 6th Grade Completion Completed 6th Grade 6th Grade Completion Indicates that 7th grade is the highest level of educational achievement. C67129 Organism Attribute 7th Grade Completion C1883651 _7th_Grade 7th Grade 7th Grade Completion Completed 7th Grade 7th Grade Completion Indicates that 8th grade is the highest level of educational achievement. C67130 Organism Attribute 8th Grade Completion C1883653 _8th_Grade 8th Grade 8th Grade Completion Completed 8th Grade 8th Grade Completion Indicates that 9th grade is the highest level of educational achievement. C67131 Organism Attribute 9th Grade Completion C1883654 _9th_Grade 9th Grade 9th Grade Completion Completed 9th Grade 9th Grade Completion Indicates that 10th grade is the highest level of educational achievement. C67132 Organism Attribute 10th Grade Completion C1883613 _10th_Grade 10th Grade 10th Grade Completion Completed 10th Grade 10th Grade Completion Indicates that 11th grade is the highest level of educational achievement. C67133 Organism Attribute 11th Grade Completion C1883614 _11th_Grade 11th Grade 11th Grade Completion Completed 11th Grade 11th Grade Completion Indicates that a person was in school through 12th grade but they did not receive a high school diploma. C67134 Organism Attribute 12th Grade Completion, No Diploma C1883615 _12th_Grade 12th Grade 12th Grade Completion 12th Grade Completion, No Diploma 12th Grade, No Diploma 12th Grade Completion, No Diploma Indicates that a person has received a General Equivalency Diploma in lieu of a high school diploma. C67135 Organism Attribute General Equivalency Diploma Completion C1880947 GDC OORO General_Equivalency_Diploma High School Graduate or GED GED GED or Equivalent General Equivalency Diploma General Equivalency Diploma Completion General Equivalency Diploma Received General Equivalency Diploma Completion Indicates that a person has attended high school and has received a high school diploma. C67136 Organism Attribute High School Completion C0870649 ACC/AHA GDC OORO Completed secondary education through 12th or 13th grade as required by the school system. High_School_Graduate High School Graduate or GED High School High School Completion High School Diploma Received High School Graduate High school completion High School Completion Indicates that a person has attended college but that they did not receive any degree. C67137 Organism Attribute Some College Completion C1883065 GDC OORO Some_College Vocational College or Some College College no degree Some College Some College Attendence Some College Completion Some College, No Degree Some College Completion Indicates that a person has received a degree from a 2 year college program. C67140 Organism Attribute Associate Academic Degree Completion C1879750 OORO Associate_Degree_Academic Academic Associate Degree Associate Academic Degree Completion Associate Degree Associate Degree Completion Associate Degree Received Associates degree academic Associate Academic Degree Completion Indicates that a person has attended or received a degree from an occupational, technical, or vocational program as their highest level of educational achievement. C67141 Organism Attribute Vocational Program Completion C1883542 GDC OORO Vocational_Degree Vocational College or Some College Associates degree vocational Vocational Degree Vocational Degree Completion Vocational Degree Received Vocational Program Completion Vocational Program Completion Indicates a person who has smoked at least 100 cigarettes in his or her lifetime and who currently smokes every day. C67145 Organism Attribute Current Every Day Smoker C3266136 ACC/AHA GDC Current_Every_Day_Smoker Every day Current Every Day Smoker Current every day smoker Daily Smoker Every Day Smoker Every day Current Every Day Smoker Indicates a person who has smoked at least 100 cigarettes in his or her lifetime, who smokes now, but does not smoke every day. C67146 Organism Attribute Current Some Day Smoker C1880200 ACC/AHA GDC Current_Some_Day_Smoker Some days Chipper Current Some Day Smoker Current some day smoker Non-Daily Smoker Occasional Smoker Some Day Smoker Some days Current Some Day Smoker An adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes. Includes daily smokers and non-daily smokers (also known as occasional smokers). C67147 Organism Attribute Current Smoker Current Smoker C3241966 CTRP GDC Current_Smoker Current Smoker Current Smoker Smoker Current Smoker A person who has quit smoking at the time of the interview but has smoked at least 100 cigarettes in their life. C67148 Organism Attribute Former Smoker Former Smoker C0337671 ACC/AHA CTRP Former_Smoker Former Smoker Former smoker Prior Smoker Former Smoker Indicates a person who is known to have smoked but whose current smoking status is unknown. C67150 Organism Attribute Smoker, Current Status Unknown C1883049 ACC/AHA Smoker_Current_Status_Unknown Smoker, Current Status Unknown Smoker, current status unknown Smoker, Current Status Unknown Indicates that a person's smoking status is unknown. C67151 Organism Attribute Unknown If Ever Smoked C1883465 ACC/AHA Unknown_If_Ever_Smoked Unknown If Ever Smoked Unknown if ever smoked Unknown If Ever Smoked Denotes the inhabitants of the Bahamas, a person from there, or their descendants elsewhere. C67271 Population Group Bahamian C1553336 CDISC A person having origins in any of the original peoples of the Bahamas. Bahamian BAHAMIAN Bahamian Bahamian A joint federal and state program that provides assistance with healthcare costs to people with low income and limited resources. Medicaid is run by state and local governments within federal guidelines. Healthcare bills are paid from federal, state and local tax funds. The eligibility for the program does not depend on a person's age. Participating beneficiaries usually pay no part of costs for covered healthcare expenses except a small co-payment required in some cases. C68633 Intellectual Product Medicaid C0025071 OORO A health insurance program for people who cannot afford regular medical care. The program is run by U.S. federal, state, and local governments. People who receive Medicaid may have to pay a small amount for the services they get. Medicaid Medicaid Medicaid Program Public Health Insurance Medicaid Medicaid A person who inhales or has inhaled combustible products of organic material during their lifetime. C68751 Organism Attribute Smoker C0337664 Smoker Current or Former Smoker Smoker Smoker The age of a person at the start of a specific event. C69217 Organism Attribute Age Started C2348002 GDC The age of a patient on the first occurrence of an event, such as the first use of a medication. Age_Started Age Started age at onset age_at_onset Age Started The age of a person who is the subject in a study. C69260 Organism Attribute Subject Age C2348575 BRIDG SeroNet Age of patient who is the subject of observations. Subject_Age Age Subject Age subjectAge Subject Age Indicates that kindergarten is the highest level of education achievement. C70432 Organism Attribute Kindergarten Completion CL448897 Kindergarten_Completion Kindergarten Kindergarten Completion Kindergarten Only Kindergarten Completion Indicates that preschool is the highest level of education achievement. C70433 Organism Attribute Preschool Completion C0681405 Preschool_Completion Preschool Preschool Completion Preschool Only Preschool Completion Indicates that a person was instructed in an educational program outside of established schools, especially in the home. C70434 Organism Attribute Home School Completion C0578822 Home_School Home School Home School Attendence Home School Completion Home Schooled Home Schooling Home School Completion Indicates that a person has received a degree for successful completion of a program of studies that normally requires at least 4-5 years of full-time equivalent college-level work. C70555 Organism Attribute Bachelor's Degree Completion C2346951 OORO Bachelor_Degree_Completion Bachelor's Degree Bachelor's Degree Completion Bachelor's Degree Received Bachelor's degree Bachelor's Degree Completion Indicates that a person has received a degree for completion of at least one year of prescribed study beyond the bachelor's degree. C70556 Organism Attribute Master's Degree Completion C2347079 OORO Masters_Degree_Completion Master's Degree Master's Degree Completion Master's Degree Received Master's degree Master's Degree Completion Indicates that a person has received a degree for completion of the highest award earned for graduate study. C70557 Organism Attribute Academic Doctorate Degree Completion C2348318 OORO Doctorate_Degree_Completion Academic Doctorate Degree Completion Doctoral Degree Doctoral Degree Completion Doctoral Degree Received Doctorate Degree Doctorate Degree Completion Doctorate Degree Received Doctorate degree Academic Doctorate Degree Completion Indicates that a person has received a degree allowing them to practice a profession, such as law, medicine, music, or ministry. C70558 Organism Attribute Professional Doctorate Degree Completion C2347690 GDC OORO Professional_Doctorate_Degree_Completion Professional or Graduate Degree Professional Doctoral Degree Professional Doctoral Degree Completion Professional Doctoral Degree Received Professional Doctorate Degree Professional Doctorate Degree Completion Professional Doctorate Degree Received Professional degree Professional Doctorate Degree Completion An insurance program designed to financially compensate an employee in the event of an injury sustained while working. C70692 Intellectual Product Workers Compensation Plan C0043233 Workers_Compensation_Plan Workers Compensation Workers Compensation Plan Workers Compensation Plan An organization that integrates financing and management of healthcare with the delivery of healthcare services to an enrolled population. It employs or contracts with an organized system of providers that delivers services, manages the costs of healthcare services, as well as accessibility and quality of care for its enrolled members, and frequently shares financial risk. Managed healthcare plan can do this through a variety of means but usually this involves offering limited choices of providers to its enrollees and negotiating with providers for reimbursement costs. Typically in managed care the third party payer requires second opinions and pre-certification review for patients requiring hospital admission. C70694 Organization Managed Healthcare Plan C2346940 Managed_Healthcare_Plan Managed Care Plan Managed Healthcare Organization Managed Healthcare Plan Managed Healthcare Plan Financial coverage provided through third party reimbursement, that is designed to minimize monetary loss associated with health care costs. C70696 Intellectual Product Private Health Insurance C2347682 OORO Private_Health_Insurance Private Health Insurance Private Insurance Employment Based Private Health Insurance A demographic parameter indicating the amount of earnings made by a family. C70811 Quantitative Concept Household Income C0557163 SeroNet Household_Income Household Income Household Income The determination of the amount of ferritin present in a sample. C74737 Laboratory Procedure Ferritin Measurement C0373607 CDISC A measurement of the ferritin in a biological specimen. Ferritin_Measurement FERRITIN Ferritin Ferritin Measurement Ferritin Measurement Employment involving less than the standard or customary working time. C75562 Qualitative Concept Part Time Employment C0682294 ACC/AHA CDISC Employment involving less than the standard or customary working time. Part_Time_Employment PART-TIME Part Time Part Time Employment Part-Time Part-time Part-time Employment Working part-time for pay Part Time Employment Indicates a person has attended high school but did not complete high school and did not receive a high school diploma. C76123 Organism Attribute Not High School Graduate C2825140 Not High School Graduate Some High School Completion Started high school but didn't graduate Not High School Graduate The first weight of a newborn obtained after birth. C76325 Quantitative Concept Birth Weight C0005612 CDISC NICHD A measured weight of a newborn obtained immediately or shortly after birth. A measurement of the weight of a neonate at birth. Birth_Weight_New BRTHWT Birth Weight Birth Weight Denotes a person having origins in one of the indigenous people of South or Central America such as Mayans or Incas. C77809 Population Group South or Central American Indian C2699496 South_or_Central_American_Indian Indigenous South / Central American Indigenous South or Central American Indian South or Central American Indian South or Central American Indian Denotes a person having origins in one of the Indian people of the Caribbean. C77810 Population Group Caribbean Indian C2698999 CDISC The native people of the Caribbean. Caribbean_Indian CARIBBEAN INDIAN Caribbean Indian Caribbean Indian Denotes a person having origins in any of the countries abutting the Mediterranean Sea, principally those of Europe. C77811 Population Group Mediterranean C0240321 CDISC A person having origins in any of the original peoples of the countries surrounding the Mediterranean sea. Mediterranean MEDITERRANEAN Mediterranean Mediterranean Denotes a person of European, Middle Eastern, or North African ancestral origins whose family settled in a North American country such as the United States of America or Canada. C77812 Population Group North American C0425358 North_American North American North American Denotes a person having origins in a northern country of Africa such as Egypt, Sudan, Libya, Algeria, Morocco, or Tunisia. C77813 Population Group North Coast of Africa C2698500 CDISC A person having origins in any of the original peoples of North Africa. North_Coast_of_Africa_Origin NORTH AFRICAN North Coast of Africa North Coast of Africa Origin North Coast of Africa Denotes a person having origins in any of the countries of northern Europe such as Belgium, Denmark, Austria, Switzerland, Norway, Sweden, or Great Britain. C77814 Population Group Northern European C0239310 CDISC A person having origins in any of the original peoples of Northern Europe. Northern_European NORTHERN EUROPEAN Northern European Northern European Ancestry Northern European Descent Northern European Denotes a person having origins in any of the black racial groups of Africa whose family settled in a South or Central American country such as Argentina, Brazil, or Mexico. C77815 Population Group Black South or Central American C2698522 Black_South_or_Central_American Black South or Central American Black South or Central American A person having origins in the Caribbean region who identifies as white. C77816 Population Group White Caribbean C2700273 CDISC A person having origins in the original peoples of Europe, the Middle East, or North Africa, and the Caribbean. White_Caribbean WHITE CARIBBEAN White Caribbean White Caribbean Denotes a person having origins in any of the countries of Western Europe such as Spain, Portugal, or France. C77817 Population Group Western European C0239312 CDISC A person having origins in any of the original peoples of Western Europe. Western_European WESTERN EUROPEAN Western European Western European A person having origins in the any of the countries of South America or Central America who identifies as white. C77818 Population Group White South or Central American C2700274 White_South_or_Central_American White South or Central American White South or Central American Denotes a person having origins in any of the countries of Eastern Europe such as Czechoslovakia, Poland, Croatia, Hungary, Slovenia, Former Soviet Union, or Finland. It also includes persons who call themselves Gypsies from this region. C77819 Population Group Eastern European C0239309 CDISC A person having origins in any of the original peoples of Eastern Europe. Eastern_European EASTERN EUROPEAN Eastern European Eastern European Denotes a person having origins in the region of southwest Asia, between the India subcontinent and Europe, including Kuwait, Turkey, Lebanon, Israel, Iraq, Iran, Jordan, Saudi Arabia, lands east of Pakistan or the other countries of the Arabian Peninsula. Also includes people of Jewish ethnicity including Sephardic and Ashkenazic. C77820 Population Group Middle Eastern C2698217 CDISC A person having origins in any of the original peoples of the Middle East. Middle_Eastern MIDDLE EASTERN Middle Eastern Middle Eastern The weight of a subject. C81328 Quantitative Concept Body Weight C0005910 ACC/AHA BRIDG CDISC ICDC NICHD OORO PCDC A measurement that describes the vertical force exerted by a mass of the patient as a result of gravity. Patient weight in kilograms The weight of a subject. (NCI) Weight_of_Body BW Body Weight Vital Signs – Weight Weight Weight at encounter patient weight patient_weight subjectWeight weight Body Weight A person's total income before taxes, exclusions, and deductions. C85406 Group Attribute Gross Income C2827632 Gross Income Gross Income A general term for a group of culturally similar indigenous peoples inhabiting the Arctic regions of Canada, Greenland, Russia and the United States. In Alaska, the term Eskimo is commonly used, because it includes both Yupik and Inupiat, while Inuit is not accepted as a collective term. In Canada and Greenland, the term Eskimo has fallen out of favor, as it is considered pejorative by the natives and has been replaced by the term Inuit. C86558 Population Group Inuit C0086484 Inuit Inuit The systolic and diastolic blood pressure of the newborn upon examination; the normal range of the systolic blood pressure is 60 - 90, while the normal range of the diastolic blood pressure is 20-60. C87105 Clinical Attribute Newborn Blood Pressure C2828171 NICHD Newborn Blood Pressure Newborn Blood Pressure The weight of a subject at a specified end point. C90464 Quantitative Concept Terminal Body Weight C2983672 CDISC The weight of a subject at a specified end point. (NCI) TERMBW Terminal Body Weight Terminal Body Weight The recognition that low neighborhood socioeconomic conditions have an impact on the services and opportunities available to its residents and have a wide and long-lasting effect on their economic, social and educational development. U.S. Census data can be used to determine the concentration of poverty at the neighborhood level. C92458 Classification Concentrated Disadvantage C2985113 Concentrated Disadvantage Concentrated Neighborhood Disadvantage Neighborhood Concentrated Disadvantage Neighborhood Disadvantage Concentrated Disadvantage The height of a person while standing. C94488 Conceptual Entity Stature C0424639 ACC/AHA A measurement that describes the vertical measurement or distance from the base, or bottom, of the patient, to the top of the patient; this can be taken as the dimension of extension of a patient who cannot stand. The height of a person while standing. Stature Vital Signs – Height stature Stature standing height a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'. YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device. YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention. YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623. YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740. YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events. YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'. Yongqun He AE adverse reaction WEB: http://en.wikipedia.org/wiki/Adverse_event WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068 The OAE official website is: http://www.oae-ontology.org/. adverse event medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States," Reference: http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis. YH WEB: http://wiki.answers.com/Q/What_is_medical_intervention medical intervention a medical intervention where a patient is administered with a drug YH drug administration an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue. YH, RR, JX musculoskeletal and connective tissue disorder AE WEB: http://www.cdc.gov/niosh/programs/msd/ 10028395 A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture musculoskeletal or connective tissue AE CTCAE: E13872 an adverse event that shows a complication that occurs after a medical procedure and is directly related to the precedure itself. SS, YH post-procedural AE procedural disorder AE procedure AE procedural complication AE a procedure complication AE that occurs after a surgery. YH surgery adverse event surgical procedure AE The key difference between a surgery and a procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. Technically speaking, a surgery is a specific type of procedure. A procedure is a broad general term that refers to any series of pre-defined steps that should be followed to achieve a desired result. Therefore, a “surgical procedure” is synonymous with a “surgery.” See more: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm. surgery AE Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. YH, SS surgical procedure WEB: http://en.wikipedia.org/wiki/Surgery WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm 10042609 surgery a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body. WEB: http://medical-dictionary.thefreedictionary.com/fistula 10067143 YH, SS fistula AE HPO: HP_0010294 SIDER: C0016169 a serious AE that is due to an allergic brochospasm, which causes a serious problem with breathing and requires treatment in an emergency room. YH, JX URL: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm URL: https://en.wikipedia.org/wiki/Bronchospasm allergic brochospasm AE that requires treatment in emergency a sensory capability AE that has an outcome of pain in a patient YH, MW 10033371 pain AE CTCAE: E11167 HPO: HP_0010833 NCIt: C3303 SIDER: C0030193 a sudden death AE that occurs to an infant. According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). YH sudden infant death AE an AE that occurs in cardiovascular system. YH cardiovascular disorder AE 10007649 cardiovascular AE HPO: HP_0001626 SIDER: C0007222 an adverse event that has an outcome of an abnormal behavior and neurological phenotype. YH, JX behavior AE behavioral AE behavioral disorder AE disruptive behavioral disorder AE WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/ any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls behavioral and neurological AE MP: MP_0004924 a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus sensory capability AE MP: MP_0002067 a urinary system AE that results in the presence of blood in the urine YH, SJ, MW UMLS CUI: C0018965 (hematuria AND haematuria); UMLS CUI: C0947999 (blood urine presence) blood urine blood urine presence haematuria AE WEB: http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/ 10018867 10018870 10019450 hematuria Hematuria AE can be caused by menstruation, vigorous exercise, sexual activity, viral illness, trauma, or infection, such as a urinary tract infection (UTI), along with more serious disorders such as cancer, disease, and clotting. hematuria AE CTCAE: E13000 MP: MP_0005161 NCIt: C3090 an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine YH urinary system AE MP: MP_0005502 serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death. YH, MC serious adverse event severe adverse event WEB: http://en.wikipedia.org/wiki/Serious_adverse_event WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA serious adverse event a serious adverse event that has an outcome of death. YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm 10011906 10011914 death death AE CTCAE: E11080 HPO: HP_0001645 NCIt: C28554 SIDER: C1306577 a serious AE that is suspected to put the patient at substantial risk of dying at the time of the adverse event, or that the use or continued use of the device or other medical product might have resulted in the death of the patient. DJ, SS, YH, JX apparent life threatening event AE WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm 10065044 life-threating AE a serious adverse event that leads to hospitalization. Such an adverse event resulted in an admission to the hospital or prolongation of hospitalization. YH, JX adverse event leading to hospitalization WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm hospitalization AE a serious adverse event that leads to disability or permanent damage. Such an adverse event results in a substantial disruption of a person's ability to conduct normal life functions, i.e., the adverse event resulted in a significant, persistent or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities and/or quality of life. YH, JX adverse event leading to disability WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm disability or permanent damage AE a serious adverse event that resulted in congenital anomaly and bith defect, leading to suspicions that an exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child. YH, JX adverse event leading to congenital anomaly WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.thefreedictionary.com/birth+defect 10010356 congenital anomaly or birth defect AE a serious adverse event which is an adverse event that requires intervention to prevent permanent impairment or damage leads to suspicions that the use of a medical product may result in a condition which requires a medical or surgical intervention to preclude permanent impairment or damage to a patient. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm adverse event that requires intervention to prevent permanent impairment or damage an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma". SS, YH bruise AE bruising AE ecchymoses AE haematoma AE WEB: http://en.wikipedia.org/wiki/Hematoma 10006504 10018852 10019428 hematoma AE CTCAE: E13775 (hematoma); CTCAE: E11666 (brruising) HPO: HP_0001892 NCIt: C37921 (Bruising); NCIt: C50579 (Hematoma) SIDER: C0018944 an adverse event that has an outcome of disease in the biological tissue that supports, binds together and protects organs DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/connective+tissue+disease 10061087 connective tissue disorder AE HPO: HP_0003549 SIDER: C0009782 a connective tissue disorder AE that occurs in the non-skeletal tissue, usually subcutaneous and muscle tissue SZ, SS, YH WEB: http://www.reference.md/files/D018/mD018461.html 10062255 soft tissue infection soft tissue infection AE CTCAE: E11579 HPO: HP_0002719 NCIt: C79745 SIDER: C0149778 a death AE that has an outcome of unexpected death, 1 to 24 hours after the onset of symptoms SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sudden+death 10042434 10042435 sudden death AE CTCAE: E11171 HPO: HP_0001645 NCIt: C50911 SIDER: C0011071 a process quality that represents the level of severity of an adverse event. YH, SS AE severity severity of adverse event a severity of AE that shows sign and symptom within normal limits. YH, SS AE severity Grade 0 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_0_Adverse_Event Note the AE severity Grade 0 equals to CTCAE G0 AE severity. AE severity G0 CTCAE4: E10004 (Grade 0 Adverse Event) a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated. YH, SS AE severity Grade 1 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event Note the AE severity Grade 1 equals to CTCAE G1 AE severity. AE severity G1 CTCAE4: E10005 (Grade 1 Adverse Event) a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances). YH, SS AE severity Grade 2 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event Note the AE severity Grade 2 equals to CTCAE G2 AE severity. AE severity G2 CTCAE4: E10006 (Grade 2 Adverse Event) a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). YH, SS AE severity Grade 3 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event Note the AE severity Grade 3 equals to CTCAE G3 AE severity. AE severity G3 CTCAE4: E10007 (Grade 3 Adverse Event) a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral). YH, SS AE severity Grade 4 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event Note the AE severity Grade 4 equals to CTCAE G4 AE severity. AE severity G4 CTCAE4: E10008 (Grade 4 Adverse Event) a severity of AE that results in death. YH, SS AE severity Grade 5 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event Note the AE severity Grade 5 equals to CTCAE G5 AE severity. AE severity G5 CTCAE4: E10009 (Grade 5 Adverse Event) a hospitalization AE that leads to an intial hospitalization. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm initial hospitalization AE a hospitalization AE that leads to a prolonged hospitalization. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm prolonged hospitalization AE an adverse event that shows a result of injury or procedural complication. JX, YH injury and procedural complication AE injury or procedural complication AE a pain AE that has marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. MW, YH 10016750 flank pain flank pain AE CTCAE: E12414 NCIt: C34615 a death AE that has death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. MW, YH 10016479 fetal death AE CTCAE: E12855 NCIt: C50620 a medical intervention that refers to any series of pre-defined steps that should be followed to achieve a desired result. YH, SS WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm medical procedure YH, JX a behavioral quality where the behavior in an organism is abnormal. WEB: https://en.wikipedia.org/wiki/Abnormality_(behavior) behavior abnormal quality a death AE that has cessation of life occurring during the first 28 days of life. MW, YH 10011912 death neonatal AE CTCAE: E11078 NCIt: C80082 An adverse event of hematoma in the subcapsular space of the kidney. This event occurs after a medical intervention, and may be caused by a tumor, trauma, vasculitis, renal infarction, or other disease process. YH, EO https://medical-dictionary.thefreedictionary.com/subcapsular+hematoma subcapsular hematoma subcapsular hematoma AE An adverse event of hematoma occurring around the kidney. YH, EO perinephric hematoma perinephric hematoma AE YH, EO arteriovenous fistulae arteriovenous fistula arteriovenous fistula AE An adverse event of surgery that leads to the puncturing of an adjacent organ. For example, a needle to the kidney may puncture the adjacent organs. Jennifer Schaub, Oliver He puncturing of adjacent organs https://www.ncbi.nlm.nih.gov/books/NBK493205/ puncturing of adjacent organ AE A date of specimen collection for the first collection of blood from a donor. Person: Chris Stoeckert, Helena Ellis, Jie Zheng OBIB NCI BBRB first blood draw date A date of specimen collection for the first collection of a tissue from a donor. Person: Chris Stoeckert, Helena Ellis, Jie Zheng OBIB NCI BBRB first tissue removed date A date of specimen collection on which the surgery was performed during which the specimen was collected. Person: Chris Stoeckert, Helena Ellis, Jie Zheng NCI BBRB, OBIB NCI BBRB date of surgical removal of specimen A data item that indicates the time when the collection of a specimen occurred. Alice Nzinga Mathias Brochhausen date of specimen preparation It is denoted by Date in ISO-standard (8601) time format. date of specimen collection planned process planned process Injecting mice with a vaccine in order to test its efficacy A process that realizes a plan which is the concretization of a plan specification. A processual entity that realizes a plan which is the concretization of a plan specification. 'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.) We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some objectives is a planned process. Bjoern Peters branch derived 6/11/9: Edited at workshop. Used to include: is initiated by an agent This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call) http://purl.obolibrary.org/obo/obi.owl planned process planned process clinical research coordinator role a worker role comprised of handling the administrative duties of a trial or study. Person:Jennifer Fostel clinical research coordinator clinical research coordinator role processed material Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples Is a material entity that is created or changed during material processing. PERSON: Alan Ruttenberg processed material investigation Lung cancer investigation using expression profiling, a stem cell transplant investigation, biobanking is not an investigation, though it may be part of an investigation a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s). Bjoern Peters OBI branch derived Could add specific objective specification Following OBI call November 2012,26th: it was decided there was no need for adding "achieves objective of drawing conclusion" as existing relations were providing equivalent ability. this note closes the issue and validates the class definition to be part of the OBI core editor = PRS study investigation evaluant role When a specimen of blood is assayed for glucose concentration, the blood has the evaluant role. When measuring the mass of a mouse, the evaluant is the mouse. When measuring the time of DNA replication, the evaluant is the DNA. When measuring the intensity of light on a surface, the evaluant is the light source. a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role Role call - 17nov-08: JF and MC think an evaluant role is always specified input of a process. Even in the case where we have an assay taking blood as evaluant and outputting blood, the blood is not the specified output at the end of the assay (the concentration of glucose in the blood is) examples of features that could be described in an evaluant: quality.... e.g. "contains 10 pg/ml IL2", or "no glucose detected") GROUP: Role Branch OBI Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term. evaluant role assay Assay the wavelength of light emitted by excited Neon atoms. Count of geese flying over a house. A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies. 12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation. PlanAndPlannedProcess Branch measuring scientific observation OBI branch derived study assay any method assay sample preparation for assay A sample_preparation_for_assay is a protocol_application including material_enrollments and biomaterial_transformations. definition_source: OBI. PlanAndPlannedProcess Branch study OBI branch derived sample preparation for assay diagnosis textual entity diagnosis is an assessment of a disease or injury, its likely prognosis and treatment. Jennifer Fostel diagnosis textual entity culture medium A growth medium or culture medium is a substance in which microorganisms or cells can grow. Wikipedia, growth medium, Feb 29, 2008 a processed material that provides the needed nourishment for microorganisms or cells grown in vitro. changed from a role to a processed material based on on Aug 22, 2011 dev call. Details see the tracker item: http://sourceforge.net/tracker/?func=detail&aid=3325270&group_id=177891&atid=886178 Modification made by JZ. Person: Jennifer Fostel, Jie Zheng OBI culture medium reagent role Buffer, dye, a catalyst, a solvating agent. A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer. PERSON:Matthew Brush reagent PERSON:Matthew Brush Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term. May 28 2013. Updated definition taken from ReO based on discussions initiated in Philly 2011 workshop. Former defnition described a narrower view of reagents in chemistry that restricts bearers of the role to be chemical entities ("a role played by a molecular entity used to produce a chemical reaction to detect, measure, or produce other substances"). Updated definition allows for broader view of reagents in the domain of biomedical research to include larger materials that have parts that participate chemically in a molecular reaction or interaction. (copied from ReO) Reagents are distinguished from instruments or devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in or have parts that participate in some chemical interaction or reaction during their intended participation in some technique. By contrast, instruments do not participate in a chemical reaction/interaction during the technique. Reagents are distinguished from study subjects/evaluants in that study subjects and evaluants are that about which conclusions are drawn and knowledge is sought in an investigation - while reagents, by definition, are not. It should be noted, however, that reagent and study subject/evaluant roles can be borne by instances of the same type of material entity - but a given instance will realize only one of these roles in the execution of a given assay or technique. For example, taq polymerase can bear a reagent role or an evaluant role. In a DNA sequencing assay aimed at generating sequence data about some plasmid, the reagent role of the taq polymerase is realized. In an assay to evaluate the quality of the taq polymerase itself, the evaluant/study subject role of the taq is realized, but not the reagent role since the taq is the subject about which data is generated. In regard to the statement that reagents are 'distinct' from the specified outputs of a technique, note that a reagent may be incorporated into a material output of a technique, as long as the IDENTITY of this output is distinct from that of the bearer of the reagent role. For example, dNTPs input into a PCR are reagents that become part of the material output of this technique, but this output has a new identity (ie that of a 'nucleic acid molecule') that is distinct from the identity of the dNTPs that comprise it. Similarly, a biotin molecule input into a cell labeling technique are reagents that become part of the specified output, but the identity of the output is that of some modified cell specimen which shares identity with the input unmodified cell specimen, and not with the biotin label. Thus, we see that an important criteria of 'reagent-ness' is that it is a facilitator, and not the primary focus of an investigation or material processing technique (ie not the specified subject/evaluant about which knowledge is sought, or the specified output material of the technique). reagent role material processing A cell lysis, production of a cloning vector, creating a buffer. A planned process which results in physical changes in a specified input material PERSON: Bjoern Peters PERSON: Frank Gibson PERSON: Jennifer Fostel PERSON: Melanie Courtot PERSON: Philippe Rocca Serra material transformation OBI branch derived material processing study subject role Human subjects in a clinical trial, rats in a toxicogenomics study, tissue cutlures subjected to drug tests, fish observed in an ecotoxicology study. Parasite example: people are infected with a parasite which is then extracted; the particpant under investigation could be the parasite, the people, or a population of which the people are members, depending on the nature of the study. Lake example: a lake could realize this role in an investigation that assays pollution levels in samples of water taken from the lake. A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected. A participant can realize both "specimen role" and "participant under investigation role" at the same time. However "participant under investigation role" is distinct from "specimen role", since a specimen could somehow be involved in an investigation without being the thing that is under investigation. GROUP: Role Branch OBI Following OBI call November 2012,26th: 1. it was decided there was no need for moving the children class and making them siblings of study subject role. 2. it also settles the disambiguation about 'study subject'. This is about the individual participating in the investigation/study, Not the 'topic' (as in 'toxicity study') of the investigation/study This note closes the issue and validates the class definition to be part of the OBI core editor = PRS participant under investigation role responsible party role he THERAPIST has the ability to print a separate statement for the patient and each responsible party. http://www.beaverlog.com/therapist/ez_support/billing/responsible_party_statements.htm a study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study Person: Jennifer Fostel responsible party OBI responsible party role specimen role liver section; a portion of a culture of cells; a nemotode or other animal once no longer a subject (generally killed); portion of blood from a patient. a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation 22Jun09. The definition includes whole organisms, and can include a human. The link between specimen role and study subject role has been removed. A specimen taken as part of a case study is not considered to be a population representative, while a specimen taken as representing a population, e.g. person taken from a cohort, blood specimen taken from an animal) would be considered a population representative and would also bear material sample role. Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation. blood taken from animal: animal continues in study, whereas blood has role specimen. something taken from study subject, leaves the study and becomes the specimen. parasite example - when parasite in people we study people, people are subjects and parasites are specimen - when parasite extracted, they become subject in the following study specimen can later be subject. GROUP: Role Branch OBI specimen role worker role Public sector workers in states that run their own OSHA programs are covered by those states. http://www.osha.gov/as/opa/worker/index.html a personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline "executes the study plan" includes the suppliers and manufacturers of reagents and other materials used in the study Person:Jennifer Fostel worker OBI worker role population PMID12564891. Environ Sci Technol. 2003 Jan 15;37(2):223-8. Effects of historic PCB exposures on the reproductive success of the Hudson River striped bass population. a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area 1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: http://code.google.com/p/popcomm-ontology/ PERSON: Philippe Rocca-Serra adapted from Oxford English Dictionnary rem1: collection somehow always involve a selection process population investigation agent role The person perform microarray experiments and submit microarray results (including raw data, processed data) with experiment description to ArrayExpress. A role borne by an entity and that is realized in a process that is part of an investigation in which an objective is achieved. These processes include, among others: planning, overseeing, funding, reviewing. Implementing a study means carrying out or performing the study and providing reagents or other materials used in the study and other tasks without which the study would not happen. Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable representing investigations run by robot scientists such as ADAM (King et al, Science, 2009) GROUP: Role Branch investigator OBI Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term. study person role Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable investigations run by robot scientists such as ADAM (King et al, Science, 2009) investigation agent role sponsor role a responsible party role involved with any of the following activities: initiating, managing and funding a study Person: Jennifer Fostel sponsor CDISC definition: sponsor. 1. An individual, company, institution, or organization that takes responsibility for the initiation, management, and/or financing of a clinical trial. 2. A corporation or agency whose employees conduct the investigation is considered a sponsor; employees are considered investigators sponsor role organization PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods. An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. An organization is a continuant entity which can play roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that. The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based: 1) there are organization_member_roles (president, treasurer, branch editor), with individual persons as bearers 2) there are organization_roles (employer, owner, vendor, patent holder) 3) an organization has a charter / rules / bylaws, which specify what roles there are, how they should be realized, and how to modify the charter/rules/bylaws themselves. It is debatable what the organization itself is (some kind of dependent continuant or an aggregate of people). This also determines who/what the bearer of organization_roles' are. My personal favorite is still to define organization as a kind of 'legal entity', but thinking it through leads to all kinds of questions that are clearly outside the scope of OBI. Interestingly enough, it does not seem to matter much where we place organization itself, as long as we can subclass it (University, Corporation, Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO, W3C, University of Oklahoma), and have it play roles. This leads to my proposal: We define organization through the statements 1 - 3 above, but without an 'is a' statement for now. We can leave it in its current place in the is_a hierarchy (material entity) or move it up to 'continuant'. We leave further clarifications to BFO, and close this issue for now. PERSON: Alan Ruttenberg PERSON: Bjoern Peters PERSON: Philippe Rocca-Serra PERSON: Susanna Sansone GROUP: OBI organization protocol PCR protocol, has objective specification, amplify DNA fragment of interest, and has action specification describes the amounts of experimental reagents used (e..g. buffers, dNTPS, enzyme), and the temperature and cycle time settings for running the PCR. A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process. PlanAndPlannedProcess Branch OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29) study protocol protocol analyte role Glucose in blood (measured in an assay to determine the concentration of glucose). A measurand role borne by a molecular entity or an atom and realized in an analyte assay which achieves the objective to measure the magnitude/concentration/amount of the analyte in the entity bearing evaluant role. interestingly, an analyte is still an analyte even if it is not detected. for this reason it does not bear a specified input role pH (technically the inverse log of [H+]) may be considered a quality; this remains to be tested. qualities such as weight, color are not assayed but measured, so they do not fall into this category. GROUP: Role Branch OBI Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term. analyte role interpreting data Concluding that a gene is upregulated in a tissue sample based on the band intensity in a western blot. Concluding that a patient has a infection based on measurement of an elevated body temperature and reported headache. Concluding that there were problems in an investigation because data from PCR and microarray are conflicting. Concluding that 'defects in gene XYZ cause cancer due to improper DNA repair' based on data from experiments in that study that gene XYZ is involved in DNA repair, and the conclusion of a previous study that cancer patients have an increased number of mutations in this gene. A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion PERSON: Bjoern Peters PERSON: Jennifer Fostel Bjoern Peters drawing a conclusion based on data planning The process of a scientist thinking about and deciding what reagents to use as part of a protocol for an experiment. Note that the scientist could be human or a "robot scientist" executing software. a process of creating or modifying a plan specification 7/18/2011 BP: planning used to itself be a planned process. Barry Smith pointed out that this would lead to an infinite regression, as there would have to be a plan to conduct a planning process, which in itself would be the result of planning etc. Therefore, the restrictions on 'planning' were loosened to allow for informal processes that result in an 'ad hoc plan '. This required changing from 'has_specified_output some plan specifiction' to 'has_participant some plan specification'. Bjoern Peters Bjoern Peters Plans and Planned Processes Branch planning hypothesis driven investigation is an investigation with the goal to test one or more hypothesis PlanAndPlannedProcess Branch OBI branch derived hypothesis driven investigation hypothesis generating investigation is an investigation in which data is generated and analyzed with the purpose of generating new hypothesis PlanAndPlannedProcess Branch OBI branch derived hypothesis generating investigation transfer function A transfer function is a function to displace a material from one location to another. Bill Bug Daniel Schober Frank Gibson Melanie Courtot transfer function extract Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. Cancer Res. 2008 Oct 15;68(20):8489-98. PMID: 18922923 an extract is a material entity which results from an extraction process PERSON: Philippe Rocca-Serra extracted material GROUP: OBI Biomatrial Branch extract needle Ovarian carcinoma presenting with axillary lymph node metastasis: A case diagnosed by fine-needle aspiration and brief review of the literature. Diagn Cytopathol. 2008 Oct 16. PMID: 18925569 A needle is a sharp, hollow device used to penetrate tissue or soft material. When attached to a syringe. it allows delivery of a specific volume of liquid or gaseous mixture. Philippe Rocca-Serra OBI Instrument needle analyte measurement objective The objective to measure the concentration of glucose in a blood sample an assay objective to determine the presence or concentration of an analyte in the evaluant PERSON: Bjoern Peters PPPB branch analyte measurement objective assay objective the objective to determine the weight of a mouse. an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role) PPPB branch PPPB branch assay objective analyte assay example of usage: In lab test for blood glucose, the test is the assay, the blood bears evaluant_role and glucose bears the analyte role. The evaluant is considered an input to the assay and the information entity that records the measurement of glucose concentration the output An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant. Alan Ruttenberg Bjoern Peters Helen Parkinson Philippe Rocca-Serra Alan Ruttenberg Bjoern Peters Helen Parkinson OBI Planned process branch Philippe Rocca-Serra analyte assay measure function A glucometer measures blood glucose concentration, the glucometer has a measure function. Measure function is a function that is borne by a processed material and realized in a process in which information about some entity is expressed relative to some reference. PERSON: Daniel Schober PERSON: Helen Parkinson PERSON: Melanie Courtot PERSON:Frank Gibson measure function material transformation objective The objective to create a mouse infected with LCM virus. The objective to create a defined solution of PBS. an objective specifiction that creates an specific output object from input materials. PERSON: Bjoern Peters PERSON: Frank Gibson PERSON: Jennifer Fostel PERSON: Melanie Courtot PERSON: Philippe Rocca-Serra artifact creation objective GROUP: OBI PlanAndPlannedProcess Branch material transformation objective study design execution injecting a mouse with PBS solution, weighing it, and recording the weight according to a study design. a planned process that carries out a study design removed axiom has_part some (assay or 'data transformation') per discussion on protocol application mailing list to improve reasoner performance. The axiom is still desired. branch derived 6/11/9: edited at workshop. Used to be: study design execution is a process with the objective to generate data according to a concretized study design. The execution of a study design is part of an investigation, and minimally consists of an assay or data transformation. study design execution clinical chemistry assay Influence of hydroxyethyl starch (6% HES 130/0.4) administration on hematology and clinical chemistry parameters. An analyte assay which uses analytical methods to produce measurements and data on the concentration of chemical parameters (analytes) present in a bodily fluid collected from an organism. Philippe Rocca-Serra chemical pathology detection of analyte in blood sample url:https://en.wikipedia.org/wiki/Clinical_chemistry clinical chemistry assay scattered molecular aggregate the sodium and chloride ions in a glass of salt water A scattered molecular aggregate is a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates PERSON: Alan Ruttenberg Collective Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. With inspiration from the paper Granularity, scale and collectivity: When size does and does not matter, Alan Recto, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349 scattered molecular aggregate material separation objective The objective to obtain multiple aliquots of an enzyme preparation. The objective to obtain cells contained in a sample of blood. is an objective to transform a material entity into spatially separated components. PPPB branch PPPB branch material separation objective specimen collection process drawing blood from a patient for analysis, collecting a piece of a plant for depositing in a herbarium, buying meat from a butcher in order to measure its protein content in an investigation A planned process with the objective of collecting a specimen. Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation. Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role. Philly2013: The specimen_role for the specimen is created during the specimen collection process. label changed to 'specimen collection process' on 10/27/2014, details see tracker: http://sourceforge.net/p/obi/obi-terms/716/ Bjoern Peters specimen collection 5/31/2012: This process is not necessarily an acquisition, as specimens may be collected from materials already in posession 6/9/09: used at workshop specimen collection process enzyme-linked immunosorbent assay 1) Detection of IL-2 (analyte) in a cell supernatant (evaluant), using plate bound anti IL-2 antibodies, and a reporter enzyme-linked reporter antibody. 2) Measurement of IgG antibody (analyte) titer in a serum sample (evaluant) using plate bound antigen and a reporter anti-IgG antibody. An analyte assay where binding of an enzyme linked antibody to a material entity that is immobilized on solid support is detected utilizing a chemiluminescent reaction. Depending on the setup, the enzyme-linked antibody could be binding directly to the analyte, or it serves as a secondary antibody detecting binding of the primary antibody to the analyte. IEDB ELISA IEDB enzyme-linked immunosorbent assay sample from organism a material obtained from an organism in order to be a representative of the whole 5/29: This is a helper class for now we need to work on this: Is taking a urine sample a material separation process? If not, we will need to specify what 'taking a sample from organism' entails. We can argue that the objective to obtain a urine sample from a patient is enough to call it a material separation process, but it could dilute what material separation was supposed to be about. sample from organism portioning objective The objective to obtain multiple aliquots of an enzyme preparation. A material separation objective aiming to separate material into multiple portions, each of which contains a similar composition of the input material. portioning objective separation into different composition objective The objective to obtain cells contained in a sample of blood. A material separation objective aiming to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities). We should be using has the grain relations or concentrations to distinguish the portioning and other sub-objectives separation into different composition objective specimen collection objective The objective to collect bits of excrement in the rainforest. The objective to obtain a blood sample from a patient. A objective specification to obtain a material entity for potential use as an input during an investigation. Bjoern Peters Bjoern Peters specimen collection objective material sample role a role borne by a portion of blood taken to represent all the blood in an organism; the role borne by a population of humans with HIV enrolled in a study taken to represent patients with HIV in general. A material sample role is a specimen role borne by a material entity that is the output of a material sampling process. 7/13/09: Note that this is a relational role: between the sample taken and the 'sampled' material of which the sample is thought to be representative off. material sample role material sample blood drawn from patient to measure his systemic glucose level. A population of humans with HIV enrolled in a study taken to represent patients with HIV in general. A material entity that has the material sample role OBI: workshop sample population sample material sample material maintenance objective An objective specification maintains some or all of the qualities of a material over time. PERSON: Bjoern Peters PERSON: Bjoern Peters material maintenance objective informed consent process A planned process in which a person or their legal representative is informed about key facts about potential risks and benefits of a process and makes a documented decision as to whether the person in question will participate. 09/28/2009 Alan Ruttenberg: This is made a subclass of the higher level processual entity in BFO because I don't want to take a stand on whether it is a process aggregate. Analogous to the situation with Material entity. Person:Alan Ruttenberg http://clinicaltrials.gov/ct2/info/glossary#informed 2009/09/28 Alan Ruttenberg. Fucoidan-use-case informed consent process measurement device A ruler, a microarray scanner, a Geiger counter. A device in which a measure function inheres. GROUP:OBI Philly workshop OBI measurement device material maintenance a process with that achieves the objective to maintain some or all of the characteristics of an input material over time material maintenance categorical measurement datum A measurement datum that is reported on a categorical scale Bjoern Peters nominal mesurement datum Bjoern Peters categorical measurement datum service consumer role A biologist who uses a sequencing services fulfills the role of a service consumer a role which inheres in a person who uses a service Person:Helen Parkinson OBI service consumer role service provider role Jackson Lab provides experimental animals, EBI provides training on databases, a core facility provides access to a DNA sequencer. is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person PERSON:Helen Parkinson service provider role processed specimen A tissue sample that has been sliced and stained for a histology study. A blood specimen that has been centrifuged to obtain the white blood cells. A specimen that has been intentionally physically modified. Bjoern Peters Bjoern Peters A tissue sample that has been sliced and stained for a histology study. processed specimen device A voltmeter is a measurement device which is intended to perform some measure function. An autoclave is a device that sterlizes instruments or contaminated waste by applying high temperature and pressure. A material entity that is designed to perform a function in a scientific investigation, but is not a reagent. 2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of "device", and are enumerating the types of roles that a reagent can perform. 2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions. Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear. For example: (1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component. This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part. (2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay. (3) A gel running box is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it. This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel. In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation). In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay. PERSON: Helen Parkinson instrument OBI development call 2012-12-17. device sequence data example of usage: the representation of a nucleotide sequence in FASTA format used for a sequence similarity search. A measurement datum that representing the primary structure of a macromolecule(it's sequence) sometimes associated with an indicator of confidence of that measurement. Person:Chris Stoeckert GROUP: OBI sequence data dose An organism has been injected 1ml of vaccine A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. dose nucleic acid extract An extract that is the output of an extraction process in which nucleic acid molecules are isolated from a specimen. PERSON: Jie Zheng UPenn Group nucleic acid extract nucleic acid sequencer An device that is used to determine the order of nucleotides in nucleic acid sequences. PERSON: Erik Segerdell PERSON: Erik Segerdell nucleic acid sequencer protein sequencer An device that is used to determine the order of amino acids in protein sequences. PERSON: Erik Segerdell PERSON: Erik Segerdell protein sequencer service providing a training course for UCSD employees how to run a DNA sequencer; sequencing a DNA sample provided by a service consumer restricted to non-human samples; giving access to tissue samples in a biobank within OHSU; JAX shipping mice from their colony A planned process in which a service provider performs a task (i.e. a planned process) for a service consumer. Carlo; Matt OBI workshop San Diego 2011 service specimen from organism A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm). PERSON: Chris Stoeckert, Jie Zheng tissue specimen MO_954 organism_part specimen from organism material maintenance service model organism colony maintanance A material processing service in which a service provider makes physical modifications to a specified input material, such that at least one of the specified outputs of this process is a modified version of a specified input material. PERSON: Carlo Torniai PERSON: Matthew Brush PERSON: Matthew Brush Here we need to go back to the defintoin of storage process. It has object specification which is material maintenance. Not necessareley a material maintenance is needed in a storage process. material maintenance service material service A service performing DNA sequencing, a service preforming cell analysis. A service performing cell line immortalization A service which has a material entity as specified input and/or specified output. PERSON: Carlo Torniai PERSON: Matthew Brush PERSON: Carlo Torniai material service material analysis service Services performing DNA sequencing or Cell Analysis A service in which a service consumer provides some input material and a service provider performs some analysis of this material to generate data that is returned to the service consumer. PERSON: Carlo Torniai PERSON: Matthew Brush PERSON: Matthew Brush material analysis service material storage service A service that offers liquid nitrogen stroage. A storage service in which a service consumer provides some material as input which a service provider stores and returns as output. PERSON: Carlo Torniai PERSON: Matthew Brush PERSON: Matthew Brush material storage service specimen identifier A CRID symbol denotes a specimen and used to distinguish one specimen from another in an investigation. Person: Chris Stoeckert, Jie Zheng specimen ID NIAID GSCID-BRC metadata working group Specimen ID NIAID GSCID-BRC specimen identifier selection criterion rats should be aged between 6 and 8 weeks and weight between 180-250grams A directive information entity which defines and states a principle of standard by which selection process may take place. Person: Philippe Rocca-Serra selection rule OBI discussion summarized under the following tracker item : http://sourceforge.net/p/obi/obi-terms/678/ selection criterion specimen repository organization An organization that provides a service to store and distribute specimens PERSON: Chris Stoeckert, Jie Zheng NIAID GSCID-BRC metadata working group Specimen Repository NIAID GSCID-BRC specimen repository organization sequencing facility organization An organization that provides sequence determination service PERSON: Chris Stoeckert, Jie Zheng NIAID GSCID-BRC metadata working group Sequencing Facility NIAID GSCID-BRC sequencing facility organization comment on investigation A textual entity that is about any of the aspects of an investigation worth noting PERSON: Chris Stoeckert, Jie Zheng NIAID GSCID-BRC metadata working group Comments NIAID GSCID-BRC comment on investigation specimen identifier assigned by specimen repository A specimen identifier which is assigned by a specimen repository PERSON: Chris Stoeckert, Jie Zheng NIAID GSCID-BRC metadata working group Specimen Repository Sample ID NIAID GSCID-BRC specimen identifier assigned by specimen repository specimen identifier assigned by sequencing facility A specimen identifier which is assigned by a sequencing facility PERSON: Chris Stoeckert, Jie Zheng NIAID GSCID-BRC metadata working group Sample ID - Sequencing Facility NIAID GSCID-BRC specimen identifier assigned by sequencing facility sequencing service A service provides sequencing service which is the realization of some sequencing such as RNA and DNA sequencing in which the service provider role is realized. Person: Jie Zheng Adpated from 'DNA sequencing service' NIAID GSCID-BRC sequencing service conclusion based on data The conclusion that a gene is upregulated in a tissue sample based on the band intensity in a western blot. The conclusion that a patient has a infection based on measurement of an elevated body temperature and reported headache. The conclusion that there were problems in an investigation because data from PCR and microarray are conflicting. The following are NOT conclusions based on data: data themselves; results from pure mathematics, e.g. "13 is prime". An information content entity that is inferred from data. In the Philly 2013 workshop, we recognized the limitations of "conclusion textual entity", and we introduced this as more general. The need for the 'textual entity' term going forward is up for future debate. Group:2013 Philly Workshop group Group:2013 Philly Workshop group conclusion based on data cell freezing medium A processed material that serves as a liquid vehicle for freezing cells for long term quiescent stroage, which contains chemicls needed to sustain cell viability across freeze-thaw cycles. PERSON: Matthew Brush cell freezing medium selection PMID: 24023800. In this study, a set of eleven genes (VATP16, 60 S, UQCC, SMD3, EF1α, UBQ, SAND, GAPDH, ACT, PsaB, PTB2) was evaluated to identify reference genes during the first hours of interaction (6, 12, 18 and 24 hpi) between two V. vinifera genotypes and P. viticola. Two analyses were used for the selection of reference genes: direct comparison of susceptible, Trincadeira, and resistant, Regent, V. vinifera cultivars at 0 h, 6, 12, 18 and 24 hours post inoculation with P. viticola (genotype effect); and comparison of each genotype with mock inoculated samples during inoculation time-course (biotic stress effect). Three statistical methods were used, GeNorm, NormFinder, and BestKeeper, allowing to identify UBQ, EF1α and GAPDH as the most stable genes for the genotype effect. A planned process which results in the creation of group of entity from a larger group by the application of predefined criteria. this term refers to a planned process and therefore is distinct from the notion of 'natural selection', a process covering the operation of natural causes by which those individuals of a species that are best adapted to the environment tend to be preserved and to transmit their characters, while those less adapted die out, so that in the course of generations the degree of adaptation to the environment tends progressively to increase. (as defined by Oxford English Dictionary) Person: Philippe Rocca-Serra selection process OBI selection categorical value specification A value specification that is specifies one category out of a fixed number of nominal categories PERSON:Bjoern Peters categorical value specification value specification The value of 'positive' in a classification scheme of "positive or negative"; the value of '20g' on the quantitative scale of mass. An information content entity that specifies a value within a classification scheme or on a quantitative scale. This term is currently a descendant of 'information content entity', which requires that it 'is about' something. A value specification of '20g' for a measurement data item of the mass of a particular mouse 'is about' the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change 'value specification' to remove the 'is about' requirement. PERSON:Bjoern Peters value specification molecular analysis facility organization An analysis facility that includes analysis of molecular metabolites, as well as the various DNAs and RNAs. An organization that provides molecular analysis service. Chris Stoeckert, Helena Ellis MAF NCI BBRB, OBIB NCI BBRB molecular analysis facility organization age of majority inclusion criterion An inclusion criterion that uses the age of majority for a state or institution, where one is generally considered to be an adult, which if met, makes an individual suitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB age of majority inclusion criterion chemotherapy treatment exclusion criterion An exclusion criterion that defines whether chemotherapy was received or is being received for a previous or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB chemotherapy treatment exclusion criterion radiation treatment exclusion criteria An exclusion criterion that defines whether radiation was received or is being received for a previous or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB radiation treatment exclusion criteria chemotherapy treatment within the recent past exclusion criterion An exclusion criterion defined by the pathologist is defined as whether the individual received chemotherapy within the last two years. An exclusion criterion that defines whether chemotherapy was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB chemotherapy treatment within the recent past exclusion criterion radiation treatment within the recent past exclusion criterion An exclusion criterion defined by the pathologist is defined as whether the individual received radiation therapy within the last two years. An exclusion criterion that defines whether radiation was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB radiation treatment within the recent past exclusion criterion BMI range inclusion criterion An important inclusion criterion is for for the individual to have a BMI between 18.5 and 35.0 An inclusion criterion that defines and states a Body Mass Index range, which if met, makes an individual suitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB BMI range inclusion criterion blood transfusion exclusion criterion An exclusion criterion that is defined by whether the specimen donor received a whole blood transfusion within 48 hours prior to death. An exclusion criterion that is defined by whether the specimen donor received a whole blood transfusion within a specified time frame prior to death, which if met, makes a specimen donor unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB blood transfusion exclusion criterion history of metastatic cancer exclusion criterion An exclusion criterion defined as whether an individual has ever been diagnosed with metastatic cancer (cancer that spread beyond the initial site such as to other organs like brain bone or liver), which if met, makes the individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB history of metastatic cancer exclusion criterion intravenous drug use exclusion criterion Donor eligibility based on history of intravenous drug abuse in the last 5 years. An exclusion criterion defined as when an individual has a history of intravenous drug abuse for a specific timeframe, which if met, makes the individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB intravenous drug use exclusion criterion history of sex with someone with a history of blood borne infection exclusion criterion Donor eligibility based on whether the donor has a history of sex with someone who has been diagnosed or at risk for HIV/AIDS and/or HCV and/or HBV in the last 5 years. An exclusion criterion defined as whether an individual has a history of sex with someone who has been diagnosed or at risk for a blood borne infections disease in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB history of sex with someone with a history of blood borne infection exclusion criterion history of sex with someone with a history of intravenous drugs exclusion criterion Donor eligibility based on whether the donor has a history of sex with someone who has used intravenous drugs in the last 5 years. An exclusion criterion defined as whether an individual has a history of sex with someone who has used intravenous drugs in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB history of sex with someone with a history of intravenous drugs exclusion criterion HIV exclusion criterion An exclusion criterion defined as whether an individual has a history of repeatedly reactive screening assays for HIV-1 or HIV-2 antibody regardless of the results of supplemental assays, which if met, makes the individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB HIV exclusion criterion exposure to blood borne infectious disease exclusion criterion Donor eligibility based on whether the donor has been exposed to HIV/AIDS. An exclusion criterion defined as whether an individual has been exposed to a blood borne infections disease through needle sticks and/or contact with non-intact skin and/or contact with open wounds and/or contact with mucous membranes, which if met, makes the individual unsuitable for a given task or participation in a given process. Chris Stoeckert, Helena Ellis NCI BBRB, OBIB NCI BBRB exposure to blood borne infectious disease exclusion criterion measurand role A role borne by a material entity and realized in an assay which achieves the objective to measure the magnitude/concentration/amount of the measurand in the entity bearing evaluant role. Person: Alan Ruttenberg, Jie Zheng https://en.wiktionary.org/wiki/measurand https://github.com/obi-ontology/obi/issues/778 measurand role health status inclusion criterion ‘diagnosed with Type 2 diabetes mellitus’, ‘E11.4’, ’not finding of hypertension' An inclusion criterion that defines and states one or more clinically significant bodily components, dispositions, and/or bodily processes of an entity that are inferred from relevant clinical findings or self-reported, which, if met, makes the entity suitable for a given task or participation in a given process. Mathias Brochhausen MIABIS2.0 health status inclusion criterion clinically relevant lifestyle inclusion criterion 'smoking behavior’ An inclusion criterion that defines and states one or more clinically relevant planned processes that a human being actively participates in , which, if met, makes the human being suitable for a given task or participation in a given process. Mathias Brochhausen MIABIS2.0 clinically relevant lifestyle inclusion criterion clinically relevant exposure inclusion criterion 'exposure to cigarette smoke’, ‘exposure to lead through drinking water' An inclusion criterion that defines and states one or more clinically relevant histories of exposure of an entity, which, if met, makes the entity suitable for a given task or participation in a given process. Mathias Brochhausen MIABIS2.0 clinically relevant exposure inclusion criterion gravidity inclusion criterion 'pregnant’, ‘not pregnant' An inclusion criterion that defines and states one or more gravidity statuses of an organism, which, if met, makes the entity suitable for a given task or participation in a given process. Mathias Brochhausen MIABIS2.0 gravidity inclusion criterion defined population inclusion criterion inclusion based on age, sex, and living region (rural area or specified city). An inclusion criterion that is based on fitting within the defined characteristics of a population based study design. Chris Stoeckert, Mathias Brochhausen MIABIS 2.0 920 MIABIS 2.0 defined population inclusion criterion age group inclusion criterion "18-33 years old" An inclusion criterion that defines and states an age bracket which, if met, makes an entity suitable for a given task or participation in a given process. Mathias Brochhausen #839 age group inclusion criterion minimum age value specification A value specifcation that specifies the youngest age when specifying an age range. Mathias Brochhausen minimum age value specification maximum age value specification A value specifcation that specifies the oldest age when specifying an age range. Mathias Brochhausen maximum age value specification use of medication inclusion criterion "received at least 2 days of vancomycin" An inclusion criterion that defines and states a a set of medications, which, if used by an entity, makes that entity suitable for a given task or participation in a given process. Mathias Brochhausen #840 use of medication inclusion criterion hospital patient inclusion criterion "included hospital patients" An inclusion criterion defines that a human being has to be a hospital patient to be suitable for a given task or participation in a given process. Mathias Brochhausen hospital patient inclusion criterion family status inclusion criterion "included married and unmarried patients", "included divorced individuals" An inclusion criterion that defines and states one or more family statuses, which, if met, makes a human being suitable for a given task or participation in a given process. Mathias Brochhausen family status inclusion criterion sex inclusion criterion "included males and females", "included male patients" An inclusion criterion that defines and states one or more sexes which, if met, makes an entity suitable for a given task or participation in a given process. Mathias Brochhausen sex inclusion criterion country of residence inclusion criteria "include US residents" An inclusion criterion that defines and states one or more countries of residence which, if met, makes a human being suitable for a given task or participation in a given process. Mathias Brochhausen country of residence inclusion criteria ethnicity inclusion criterion "include only Hispanic individuals" An inclusion criteria that defines and states one or more ethnicities which, if met, makes an entity suitable for a given task or participation in a given process. Mathias Brochhausen ethnicity inclusion criterion organism animal fungus plant virus A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. 10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms') 13-02-2009: OBI doesn't take position as to when an organism starts or ends being an organism - e.g. sperm, foetus. This issue is outside the scope of OBI. GROUP: OBI Biomaterial Branch WEB: http://en.wikipedia.org/wiki/Organism http://purl.obolibrary.org/obo/obi.owl organism specimen Biobanking of blood taken and stored in a freezer for potential future investigations stores specimen. A material entity that has the specimen role. Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation. PERSON: James Malone PERSON: Philippe Rocca-Serra GROUP: OBI Biomaterial Branch specimen cultured cell population A cultured cell population applied in an experiment: "293 cells expressing TrkA were serum-starved for 18 hours and then neurotrophins were added for 10 min before cell harvest." (Lee, Ramee, et al. "Regulation of cell survival by secreted proneurotrophins." Science 294.5548 (2001): 1945-1948). A cultured cell population maintained in vitro: "Rat cortical neurons from 15 day embryos are grown in dissociated cell culture and maintained in vitro for 8–12 weeks" (Dichter, Marc A. "Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation." Brain Research 149.2 (1978): 279-293). A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history. 2013-6-5 MHB: This OBI class was formerly called 'cell culture', but label changed and definition updated following CLO alignment efforts in spring 2013, during which the intent of this class was clarified to refer to portions of a culture or line rather than a complete cell culture or line. PERSON:Matthew Brush cell culture sample PERSON:Matthew Brush The extent of a 'cultured cell population' is restricted only in that all cell members must share a propagation history (ie be derived through a common lineage of passages from an initial culture). In being defined in this way, this class can be used to refer to the populations that researchers actually use in the practice of science - ie are the inputs to culturing, experimentation, and sharing. The cells in such populations will be a relatively uniform population as they have experienced similar selective pressures due to their continuous co-propagation. And this population will also have a single passage number, again owing to their common passaging history. Cultured cell populations represent only a collection of cells (ie do not include media, culture dishes, etc), and include populations of cultured unicellular organisms or cultured multicellular organism cells. They can exist under active culture, stored in a quiescent state for future use, or applied experimentally. cultured cell population extraction nucleic acid extraction using phenol chloroform A material separation in which a desired component of an input material is separated from the remainder Current the output of material processing defined as the molecular entity, main component in the output material entity, rather than the material entity that have grain molecular entity. 'nucleic acid extract' is the output of 'nucleic acid extraction' and has grain 'nucleic acid'. However, the output of 'nucleic acid extraction' is 'nucleic acid' rather than 'nucleic acid extract'. We are aware of this issue and will work it out in the future. Person:Bjoern Peters Philippe Rocca-Serra extraction storage PMID: 18550121.Total Prostate Specific Antigen Stability Confirmed After Long-Term Storage of Serum at -80C. J Urol. 2008 Jun 10. A maintenance process by which material entities that are not actively metabolizing are placed in well identified location and possibly under controlled environment in ad-hoc devices/structures in order to preserve and protect them from decay/alteration and maintain availability Philippe Rocca-Serra OBI-Branch storage DNA sequencer ABI 377 DNA Sequencer, ABI 310 DNA Sequencer A DNA sequencer is an instrument that determines the order of deoxynucleotides in deoxyribonucleic acid sequences. Trish Whetzel MO DNA sequencer study design a matched pairs study design describes criteria by which subjects are identified as pairs which then undergo the same protocols, and the data generated is analyzed by comparing the differences between the paired subjects, which constitute the results of the executed study design. A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution. Editor note: there is at least an implicit restriction on the kind of data transformations that can be done based on the measured data available. PERSON: Chris Stoeckert experimental design rediscussed at length (MC/JF/BP). 12/9/08). The definition was clarified to differentiate it from protocol. study design eligibility criterion PMID: 17579629 -Eligibility criteria included: untreated ED-SCLC; age >/=70 and performance status 0-2, or age <70 and PS 3. an eligibility criterion (rule) is_a selection criterion which defines and states the requirements (positive or negative) for an entity to be considered as suitable for a given task or participation in a process. Person: Philippe Rocca-Serra eligibility rule Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group eligibility criterion inclusion criterion PMID: 23979341-The major inclusion criterion was patients in whom severe cerebral embolism was diagnosed at age 75 or younger (more than 9 in the NIHSS score on day 7 after the onset of stroke) . an inclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity suitable for a given task or participation in a given process. For instance, in a study protocol, inclusion criteria indicate the conditions that prospective subjects MUST meet to be eligible for participation in a study. Person: Philippe Rocca-Serra inclusion condition inclusion rule Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group inclusion criterion exclusion rule PMID: 17600285-Exclusion criteria included the use of any topical ophthalmic or topical oral medication and/or history of ocular or oral surgery within the past six months. an exclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity unsuitable for a given task or participation in a given process. For instance, in a study protocol, exclusion criteria indicate the conditions that prospective subjects SHOULD NOT meet to be eligible for participation in a study Person: Philippe Rocca-Serra Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group exclusion criterion human subject enrollment enlisting familiy members of HIV patients into a study A planned process with the objective to obtain a population of human subjects to participate in an investigation by determining eligibility of subjects and obtaining informed consent. As with group assignment, should the specified output here be an organism which bears a role Bjoern Peters IEDB criteria come from plan / clinical trial branch human subject enrollment collecting specimen from organism taking a sputum sample from a cancer patient, taking the spleen from a killed mouse, collecting a urine sample from a patient a process with the objective to obtain a material entity that was part of an organism for potential future use in an investigation PERSON:Bjoern Peters IEDB collecting specimen from organism material component separation Using a cell sorter to separate a mixture of T cells into two fractions; one with surface receptor CD8 and the other lacking the receptor, or purification a material processing in which components of an input material become segregated in space Bjoern Peters IEDB material component separation maintaining cell culture When harvesting blood from a human, isolating T cells, and then limited dilution cloning of the cells, the maintaining_cell_culture step comprises all steps after the initial dilution and plating of the cells into culture, e.g. placing the culture into an incubator, changing or adding media, and splitting a cell culture a protocol application in which cells are kept alive in a defined environment outside of an organism. part of cell_culturing PlanAndPlannedProcess Branch OBI branch derived maintaining cell culture 'establishing cell culture' a process through which a new type of cell culture or cell line is created, either through the isolation and culture of one or more cells from a fresh source, or the deliberate experimental modification of an existing cell culture (e.g passaging a primary culture to become a secondary culture or line, or the immortalization or stable genetic modification of an existing culture or line). PERSON:Matthew Brush PERSON:Matthew Brush A 'cell culture' as used here referes to a new lineage of cells in culture deriving from a single biological source.. New cultures are established through the initial isolation and culturing of cells from an organismal source, or through changes in an existing cell culture or line that result in a new culture with unique characteristics. This can occur through the passaging/selection of a primary culture into a secondary culture or line, or experimental modifications of an existing cell culture or line such as an immortalization process or other stable genetic modification. This class covers establishment of cultures of either multicellular organism cells or unicellular organisms. establishing cell culture sequencing assay The use of the Sanger method of DNA sequencing to determine the order of the nucleotides in a DNA template An assay the uses chemical or biochemical means to infer the sequence of a biomaterial PlanAndPlannedProcess Branch OBI branch derived sequencing assay nucleic acid extraction Phenol / chlorophorm extraction disolvation of protein content folllowed by ethanol precipitation of the nucleic acid fraction over night in the fridge followed by centrifugation to obtain a nucleic acid pellet. a material separation to recover the nucleic acid fraction of an input material PlanAndPlannedProcess Branch OBI branch derived requested by Helen Parkinson for MO. Could be defined class nucleic acid extraction adaptive immune receptor is a receptor produced by cells of the adaptive immune system with the purpose of binding epitopes. IEDB IEDB adaptive immune receptor bodily fluid specimen A specimen that is derived from some bodily fluid Christian Stoeckert ORCID:0000-0002-5714-991X Mark A. Miller ORCID:0000-0001-9076-6066 Christian Stoeckert ORCID:0000-0002-5714-991X Mark A. Miller ORCID:0000-0001-9076-6066 bodily fluid specimen A representation that is either the output of a clinical history taking or a physical examination or an image finding, or some combination thereof. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2010-07-19T10:18:02Z clinical finding A series of statements representing health-relevant qualities of a patient and of a patient's family. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2010-07-19T10:18:59Z clinical history A representation of an image that supports an inference to an assertion about some quality of a patient. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T10:21:10Z image finding A representation of a quality of a specimen that is the output of a laboratory test and that can support an inference to an assertion about some quality of the patient. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T10:21:58Z laboratory finding A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:21:20Z disease Albert Goldfain creation date: 2009-06-23T11:53:49Z bodily process A bodily process that is clinically abnormal. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:54:29Z pathological bodily process The representation of a conclusion of a diagnostic process. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T12:42:23Z diagnosis TODO: Define. Albert Goldfain http://code.google.com/p/ogms/issues/detail?id=26 creation date: 2009-11-24T04:51:11Z physical examination finding A planned process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate a disorder, the signs and symptoms of a disorder, or a pathological process A processual entity whose completion is hypothesized (by a healthcare provider) to alleviate the signs and symptoms associated with a disorder Albert Goldfain http://code.google.com/p/ogms/issues/detail?id=35 creation date: 2010-03-31T04:51:11Z http://purl.obolibrary.org/obo/ogms.owl treatment A planned process with the objective to improve the health status of a patient that directly involves the treatment, diagnosis, or prevention of disease or injury of a patient Albert Goldfain Sagar Jain http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6 creation date: 2011-02-21T09:57:44Z editor date: 2017-04-18 health care process A temporally-connected health care process that has as participants an organization or person realizing the health care provider role and a person realizing the patient role. The health care provider role and patient are realized during the health care encounter Albert Goldfain http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6 creation date: 2011-02-21T09:57:44Z health care encounter A part of an organism that has undergone a change in structural integrity and has a higher chance of dysfunction or causing dysfunction in another structure. At the scale of organism (as opposed to the cellular scale or the population scale), an injury is typically the result of a catastrophic event. Consider the implications of making 'injury' a subtype of 'disorder'. Albert Goldfain http://groups.google.com/group/ogms-discuss/browse_thread/thread/ca0ad373f27774c5 creation date: 2011-09-20T09:57:44Z http://purl.obolibrary.org/obo/ogms.owl injury A health care process that involves the interpretation of a clinical picture from a given patient (input) and the assertion to the effect that the patient has a disease, disorder, or syndrome of a certain type, or none of these (output). Albert Goldfain http://groups.google.com/group/ogms-discuss/browse_thread/thread/2a7008f311fac766/e7de486c94dfd82e creation date: 2011-09-20T09:57:44Z diagnostic process A data item that is about a patient and is the specified output of a health care process assay or diagnostic process creation date: 2018-11-27 clinical data item Social Security Number(SSN) is a Centrally Registered IDentifier that is a nine-digit number issued to U.S. citizens, permanent residents, and temporary (working) residents under section 205(c) of the Social Security Act, codified as 42 U.S.C. § 405(c). The number is issued to an individual by the Social Security Administration, an independent agency of the United States government. Its primary purpose is to track individuals for Social Security purposes. SSN http://en.wikipedia.org/wiki/Social_Security_number Cheng Chen(cxchen1@ualr.edu) social security number A social role inhering in a human being. Mathias Brochhausen William R. Hogan human social role party to a legal entity party to a legal proceeding party to a legal agreement party to a marriage contract party to a power of attorney A human social role borne by a human being being realized in behaviour which is considered socially appropriate for individuals of a specific sex in the context of a specific culture. Mathias Brochhausen http://en.wikipedia.org/wiki/Gender_role gender role A gender role borne by a human being that is realized in behaviour which is considered socially appropriate for individuals of the male sex in the context of the culture in question. Mathias Brochhausen male gender male gender role A gender role borne by a human being that is realized in behaviour which is considered socially appropriate for individuals of the female sex in the context of the culture in question. Mathias Brochhausen female gender female gender role A role in human social processes that is realized by health care processes such as seeking or providing treatment for disease and injury, diagnosing disease and injury, or undergoing diagnosis. William R. Hogan health care role Mathias Brochhausen human health care role A role borne by an organism and that is realized by presenting to a health care provider in a clinical encounter. Amanda Hicks Mathias Brochhausen patient CAFE domain expert working group. In order to avoid the presumption of the formal structures and institutions of Western civilization, bearing a patient role does not entail that the organism presents at an official place of business, with an organization formally and legally registered with various gov't entities, with a person endowed by the gov't with certain certifications. patient role A human health care role inhering in an organization or human being that is realized by a process of providing health care services to an organism. Mathias Brochhausen William R. Hogan health care provider role A health care role borne by a human being and realized by promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury and other physical and mental impairments. Mathias Brochhausen physician http://en.wikipedia.org/wiki/Physician physician role A health care role borne by a human being and realized by the care of individuals, families, and communities so they may attain, maintain, or recover optimal health and quality of life. Mathias Brochhausen nurse based on: http://en.wikipedia.org/wiki/Nursing nurse role Definition needed, but the idea is that we want to differentiate between provider and payer organizations. Some organizaitons have both roles (e.g., UPMC has a Hospital Division, a Physician Divison, and an Insurance Division). health care provider organization role person health care provider role 2 A health care provider organization role that inheres in an organization consisting of two or more physicians. Amanda Hicks physician practice A health care provider organization role that inheres in an organization that is comprised of other organizations. Amanda Hicks integrated delivery network An object aggregate of organisms. Any arbitrary collection of organisms. They need not be of the same taxonomic class. collection of organisms An object aggregate all of whose components are human beings. collection of humans A role inhering in an entity realized by social interactions in human society. Mathias Brochhausen Previous definition: A role played by an entity in human social processes. role in human social processes A role in human social processes that inheres in an organization. William R. Hogan Defined class that we will ultimately move to an application ontology. We are leaving here for now until we determine which application ontology: it is likely going to be an ontology that does not currently (2012-06-05) exist. Ditto for its current descendants. organization social role A role in human social processes that inheres in an organism. William R. Hogan Mathias Brochhausen Defined class that we will ultimately move to an application ontology. We are leaving here for now until we determine which application ontology: it is likely going to be an ontology that does not currently (2012-06-05) exist. Ditto for its current descendants. Includes animals as well as humans. For example, pet, assistance animal, animal grown for food, work animal, domesticated animal, K-9, etc. Human roles include gender role, party to legal entities, health care provider roles like doctor, nurse, etc. Previous definition: A role in human social processes played by an organism. organism social role An organization social role that is realized by a health care process. Previous definition: An organization social role played by an organization in health care processes. organization health care role A patient role that inheres in a human being. human patient role 2 An object aggregate that is not itself an organization and whose members are only organizations that have some feature in common William R. Hogan Amanda Hicks It is often convenient to group organizations together that otherwise might not even interact with one another. aggregate of organizations A role borne by a human individual or by a collection of humans regarded as possessing rights and duties enforeable at law. Mathias Brochhausen Malcolm N. Shaw: International Law. Cambridge University Press, Cambridge, 2008. We are aware of the fact that Wikipedia's definition differs from ours by saying that "Legal personality (...) is the characteristic of a non-living entity regarded by law to have the status of personhood" (http://en.wikipedia.org/wiki/Legal_personality) However, Shaw explicates: "In any legal system, certain entities, whether they be individuals or companies, will be regarded as possessing rights and duties enforceable at law. Thus an individual may prosecute or be prosecuted for assault and a company can sue for breach of contract. They are able to do this because the law recognises them as 'legal persons' possessing the capacity to have and to maintain certain rights, and being subject to perform specific duties. (...) In municipal law individuals, limited companies and public corporations are recognized as each possessing a distinct legal personality, the terms of which are circumscribed by the relevant legislation" (Shaw MN: International Law. Sixth Edition. Cambridge University Press, Cambridge, 2008). We hold that Shaw's position is ontological more prolific since it not only allows to explain how groups of individuals become recognized as unities at law, but also how different individuals can hold different legal personality roles (always against the context of one legal system). The latter will proof useful when dealing with the representing comatous patients or minorsat law in ontologies. legal person role A role that inheres in an organism and is realized by habitually smoking tobacco products. smoker role material entity role A healthcare provider role that inheres in an organization and is realized by providing inpatient and outpatient care. Mathias Brochhausen hospital role An organization social role that inheres in an organization and is realized by providing formal education to students. Mathias Brochhausen school role An organization that is the bearer of a school role. Mathias Brochhausen school organization A human social role that is realized by the process of formal education that the bearer undergoes. Mathias Brochhausen student role Mathias Brochhausen nursery school role Mathias Brochhausen primary school role Mathias Brochhausen secondary school role A trauma patient role that inheres in a homo sapiens who is under the age of 15 years. Amanda Hicks pediatric trauma patient The following definition for 'pediatric trauma patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. "A trauma patient who is under the age of 15 years." pediatric trauma patient role A patient role that inheres an organism suffering one or more injuries. Amanda Hicks injured patient The following definition for 'injured patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A patient suffering one or more injuries. injured patient role A patient role that inheres in an organism suffering a thermal, electrical, chemical or radiation burn. Amanda Hicks The following definition for 'burn patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A patient suffering a thermal, electrical, chemical or radiation burn. burn patient burn patient role A physician role that is created by training and certification in rehabilitation/physical medicine and that is realized by the provision of or supervising of the provision of rehabilitation or physical therapy to a patient. Amanda Hicks physiatrist The following definition for 'physiatrist' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A physician with training and certification in rehabilitation/physical medicine. Definition updated May 5, 2016. Original definitions was, a health care role borne by a human being and realized by training and certification in rehabilitation medicine. physiatrist role A patient role that inheres in an organism with some non-superficial traumatic injury. The role is realized by admision to a hospital, transfer from one hospital to another for the purpose of trauma care, or has death as a result of the traumatic injury. Amanda Hicks trauma patient The following definition for 'trauma patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A patient sustaining an injury who has been admitted to the hospital, transferred from one hospital to another for the purpose of trauma care, or has died as a result of the traumatic injury. trauma patient role A function that inheres in a material entity and, if realized, is realized by protecting persons and their possessions from weather and by some person or group of persons habitually sleeping in at least one site that is contained by that material entity. Amanda Hicks residence function A human or collection of humans that occupies a housing unit by storing their possessions there and habitually sleeping there thereby participating in the realization of its residence function. Amanda Hicks household Amanda hicks employee employee role A US cenus reference person role is a human social role that inheres in a Homo sapiens who is a member of a household and is realized by other persons in the household being recorded in the US census in relation to that person. Amanda Hicks http://www.census.gov/cps/about/cpsdef.html last accessed June 30, 2015 US Census reference person role A role that concretizes a socio-lega generically dependent continuant Amanda Hicks socio-legal human social role A socio-legal human social role that concretizes a socio-legally generically dependent continuat that was created by a declaration performed by an organization. Amanda Hicks human role within an organization employer role payer role party to an insurance policy Amanda Hicks A US Census unemployed role is a human social role that inheres in a human who is legally eligible to work, is conferred by the U.S. Census Bureau, and is realized by the bearer not working and either making active efforts to find employment in the four weeks prior to the reference week or waiting to be recalled from temporary layoff. US Census unemployed role A human health care provider role that inheres in a human being that is created by state licensing and that is realized by taking patient histories, performing physical exams, diagnosing illnesses, developing treatment plans, ordering lab tests, prescribing medications, counselling and educating patients, suturing wounds, and assisting in surgery under the supervision of a physician or a surgeon. US physician assistant role A physician role that inheres a human being and, if it is realized, is realized either by administering medication for the temporary general or local suppression of sensory or motor nerve function during some health care encounter or by making decisions independently of a supervising physician regarding the adminstration of such medication. anesthesiologist role surgeon role A surgeon role realized by its bearer using performing neurosurgery. neurosurgereon role A role that inheres in an organism and is realized by habitually smoking 10 or more tobacco cigerettes a day or the equivalent in other tobacco products. heavy smoker role A role that inheres in an organism and is realized by habitually smoking 1>10 tobacco cigerettes a day or the equivalent in other tobacco products. light smoker role employment data income data government assistance health care plan data health care plan data government assistance income data WIC data socio-economic data A planned process that achieves the planned objective of precision medicine objective. Specifically, it is a medical process that includes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to the individual patient. Oliver He, Jie Zheng https://en.wikipedia.org/wiki/Precision_medicine precision medicine process An investigation that is targeted for precision medicine https://en.wikipedia.org/wiki/Precision_medicine precision medicine investigation the number of people living together supported jointly by an household income https://www.healthcare.gov/income-and-household-information/household-size/ We may use IRS's definition: https://www.healthcare.gov/income-and-household-information/household-size/ household size more than 5.5 pounds (2500 grams) birth weight less than 5.5 pounds (2500 grams) birth weight unknown birth weight birth weight declined to answer individual plan insurance (paid by the member) group plan insurance through employee union USA government health plan insurance no insurance status body temperature measured orally body temprature by ear (tempanic, aural) body temprature by forhead arterial line body temperature What is other? body temprature by other measurement An education level that indicates a grade of higher than 7th but lower than 12 as the highest level of educational achievement. higher than 7th but less than 12th Grade education level direct serum bilirubin level precision medicine objective An education level that indicates the 7th grade complete or less as the highest level of educational achievement. less than 8th Grade education level An education level that indicates that the highest level of education achievement for a person is a high school completion, GED, or equivalent high school completion, GED or equivalent An information content entity that is the answer to a specific question Fred Dowd, Oliver He answer to question An answer to question where the answer is Yes. Oliver He, Fred Dowd yes answer to question An answer to question where the answer is No. Fred Dowd, Oliver He no answer to question An answer to question that indicates the response to the specified question is unknown. Fred Dowd, Oliver He, Edison Ong do not know answer to question unknown answer to question A do not know answer to question that is answered due to data unavailable Fred Dowd, Oliver He do not know due to data unavailable answer to question An answer to question where one declines to answer the specified question. Fred Dowd, Oliver He decline to answer declined to provide refuse to answer refused to answer declined to answer to question An answer to question that is not enumerated in the list and then may be entered with free text in a separate text box Oliver He, Fred Dowd other answer to question An answer to question that is not listed in the whole list of response options Oliver He, Fred Dowd none answer to question A textual entity that is a question presented in text Fred Dowd, Oliver He textual question medical history form A form with questions that is used to assess a person's eligibility to participate in a specific study (e.g., kidney precision medicine project). Fred Down, Oliver He eligibility assessment form A form with questions that includes statistical data related to particular groups within a population where a person belongs to Fred Dowd, Oliver He demographics form https://www.investopedia.com/terms/d/demographics.asp demographic information form physical measurement form A textual question that includes a list of enumerated answers Fred Dowd, Oliver He question with enumerated responses A question that has two primary and definitive answers: Yes and No, and there may be other given options like Don't know or Decline to answer. Fred Dowd, Oliver He question with yes and no responses A question with enumerated responses where one can only choose one answer. Fred Dowd, Oliver He question with enumerated responses where only one answer chosen A question with enumerated responses where one can choose multiple answers. Fred Dowd, Oliver He question with enumerated responses where multiple answers may be chosen A case report form (or CRF) is a paper or electronic questionnaire specifically used in clinical trial research Oliver He, Edison Ong, Fred Dowd, Hong Yu CRF https://en.wikipedia.org/wiki/Case_report_form https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170533/ case report form Fred Down, Oliver He laboratory result form Fred Down, Oliver He new patient form Fred Down, Oliver He biopsy procedure form kidney biopsy procedure form Fred Down, Oliver He consent form Fred Down, Oliver He paper form Medical records release form is usually required to be a paper form that should be signed by the patient who agrees to have his/her medical records released. Fred Dowd, Oliver He paper form with signature required A public health process that involves clean drinking water and adequate treatment and disposal of human and animal excreta and sewage. https://en.wikipedia.org/wiki/Sanitation sanitation A form that includes the information of contact for a person Edison Ong, Oliver He contact information form biosample collection form clinic reception form medications form participant study status form hospitalization form personal history form AKI hospitalization form CKD hospitalization form Fred Dowd, Oliver He This should be a paper form participant reported outcome measures form health literacy questionnaire form biopsy safety checklist form post biopsy form A clinical report form that covers the information about the tracking of biopsied tissue tissue tracking form pathology images upload form Dx core - .jpg images QC form diagnostic core .jpg images QC form Dx core - disease categories form diagnostic core - disease categories form central path quality metrics assessment Dx core form central path quality metrics assessment interrogation core form post-biopsy patient experience survey form adverse event entry form month of year The first month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar January The second month of the year in the Gregorian calendar. https://en.wikipedia.org/wiki/Gregorian_calendar February The third month of the year in the Gregorian calendar. https://en.wikipedia.org/wiki/Gregorian_calendar March The4th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar April The 5th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar May The 6th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar June The 7th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar July The 8th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar August The 9th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar September The 10th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar October The 11th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar November The 12th month of the year in the Gregorian calendar https://en.wikipedia.org/wiki/Gregorian_calendar December A day of a calendar week that includes covers 24 hours each day. https://en.wikipedia.org/wiki/Week day of week The first day of the week. https://en.wikipedia.org/wiki/Week Monday The second day of the week. https://en.wikipedia.org/wiki/Week Tuesday The third day of the week. https://en.wikipedia.org/wiki/Week Wednesday The fourth day of the week. https://en.wikipedia.org/wiki/Week Thursday The fifth day of the week. https://en.wikipedia.org/wiki/Week Friday The 6th day of the week. https://en.wikipedia.org/wiki/Week Saturday The 7th day of the week. https://en.wikipedia.org/wiki/Week Sunday A day when an organism (e.g., a human) is born. Oliver He, Long Tran birth date https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:person day of birth the anniversary of the birth of a person Oliver He https://en.wikipedia.org/wiki/Birthday There is a difference between birthday and birthdate: The former, such as February 29, occurs each year, while the latter is the exact date a person was born (e.g., January 15, 2001). birthday information associated with an individual Oliver He https://www.oic.qld.gov.au/guidelines/for-government/access-and-amendment/introduction-to-the-acts/what-is-personal-information personal information A name of a person, which can have different types human name https://en.wikipedia.org/wiki/Personal_name person name Christian name forename given name https://en.wikipedia.org/wiki/Personal_name person first name family name surname https://en.wikipedia.org/wiki/Personal_name person last name https://en.wikipedia.org/wiki/Personal_name person middle name 患者本人在公安户籍管理部门正式登记注册的姓氏和名称 Suyuan Peng, Hong Yu, Yongqun He https://en.wikipedia.org/wiki/Personal_name 《电子病历基本数据集 第10部分：住院病案首页》WS 445.10-2014 person full name A person name that identifies a person for legal, administrative and other official purposes Oliver He legal name https://en.wikipedia.org/wiki/Legal_name person legal name A person name that is given at birth birth name A person name that is used for a person to access a computer system. person login username A woman's surname before marriage Edison Ong, Oliver He https://en.wikipedia.org/wiki/Maiden_and_married_names maiden name A person name that is fictitious and generated for a person to perform a particular social role. pseudonym Personal information that indicates a person's status in marriage https://en.wikipedia.org/wiki/Marital_status marital status civil status married https://en.wikipedia.org/wiki/Marital_status married marital status single marrital status divorced marrital status A marital status that indicates no marriage status due to the death of his/her spouse and no remarriage. Oliver He https://en.wikipedia.org/wiki/Widow widowed marrital status legally separated marital status not married marital status An education level that indicates that the highest level of education achievement for a person. Oliver He, Edison Ong highest degree of education completed highest degree of education received highest degree of school completed education level A telephone number is a sequence of digits assigned to a fixed-line telephone subscriber station connected to a telephone line or to a wireless electronic telephony device, such as a radio telephone or a mobile telephone, or to other devices for data transmission via the public switched telephone network (PSTN) or other public and private networks. Oliver He phone number https://en.wikipedia.org/wiki/Telephone_number telephone number A telephone number used for a phone at home Oliver He home phone number home telephone number A telephone number used for a phone at work Oliver He work phone number work telephone number A telephone number that is used in a cellular device Oliver He cell phone number cellular phone number cellular telephone number The status of actively looking for employment, but not being currently employed. joblessness unemployment https://en.wikipedia.org/wiki/Unemployment NCIT_C75563 C0041674 unemployment status home postal address work postal address A series of letters or digits or both, sometimes including spaces or punctuation, included in a postal address for the purpose of sorting mail. Oliver He post code postcode https://en.wikipedia.org/wiki/Postal_code postal code A ZIP Code is a postal code used by the United States Postal Service (USPS). The term ZIP is an acronym for Zone Improvement Plan. Oliver He, Fred Dowd https://en.wikipedia.org/wiki/ZIP_Code ZIP code The personal information that indicates an individual's or his/her family's economic and social position in relation to others, based on income, education, and occupation. Oliver He https://en.wikipedia.org/wiki/Socioeconomic_status socioeconomic status An socioeconomic status that indicates the status of being employed in an occupation to perform an activity or service for wage or salary. It is the status of a worker in a company or institute on the basis of the contract of work or duration of work done. Oliver He https://definitions.uslegal.com/e/employment-status/ https://en.wikipedia.org/wiki/Employment NCIT_C25172 C0014003 employment status A state of employment in which a person works for a minimum number of hours defined as full-time by their employer. https://en.wikipedia.org/wiki/Full-time NCIT_C52658 C0682295 full time employment status a status of employment that carries fewer hours per week than a full-time job. part-time contract part-time employment https://en.wikipedia.org/wiki/Part-time_contract NCIT_C75562 C0682294 part time employment status an employment status where the work is arranged and paid on a hourly basis. NCIT_C116002 C0681101 hourly employment status The state of working for oneself rather than an employer. https://en.wikipedia.org/wiki/Self-employment NCIT_C116000 C0425092 self-employment status An employment situation where the working arrangement is limited to a certain period of time based on the needs of the employing organization. odd job temporary work https://en.wikipedia.org/wiki/Temporary_work temporary employment status An education level that indicates that the highest level of education achievement for a person is a Master's degree. M.S. degree education level MS degree completed Master's degree education level An education level that indicates that the highest level of education achievement for a person is an academic Doctorate degree Ph.D. degree education level PhD degree completed academic Doctorate degree education level An education level that indicates that a person does not have formal school education. no formal school education level An education level that indicates that the highest level of education achievement for a person is a high school completion. high school education level An education level that indicates that the highest level of education achievement for a person is a Bachelor's degree B.S. degree completed B.S. degree education level Bacholar's degree completed Bachelor's degree education level An education level that indicates that a person has obtained a degree allowing them to practice a profession, such as law, medicine, music, or ministry. NCIT_C70558 C2347690 professional doctorate degree education level M.D. completion education level Pharmacy complete education level An education level that indicates that the highest level of education achievement for a person is kindergarten completion. kindergarten completion education level An education level that indicates that the highest level of education achievement for a person is preschool. preschool completion education level An education level that indicates that the highest level of education achievement for a person is the pass of a General Education Development (GED) tests. The GED tests are a group of four subject tests which, when passed, provide certification that the test taker has United States or Canadian high school-level academic skills. general equivalency diploma completion https://en.wikipedia.org/wiki/General_Educational_Development GED education level An education level that indicates that the highest level of education achievement for a person is the 1st Grade elementary school completion. 1st Grade education level An education level that indicates that the highest level of education achievement for a person is the second Grade elementary school completion. 2nd Grade education level An education level that indicates that the highest level of education achievement for a person is the third Grade elementary school completion. 3rd Grade education level An education level that indicates that the highest level of education achievement for a person is the 4th Grade elementary school completion. 4th Grade education level An education level that indicates that the highest level of education achievement for a person is the 5th Grade elementary school completion. 5th Grade education level An education level that indicates that the highest level of education achievement for a person is the 6th Grade elementary school completion. 6th Grade education level An education level that indicates that the highest level of education achievement for a person is the 7th Grade elementary school completion. 7th Grade education level An education level that indicates that the highest level of education achievement for a person is the 8th Grade elementary school completion. 8th Grade education level An education level that indicates that the highest level of education achievement for a person is the 9th Grade elementary school completion. 9th Grade education level An education level that indicates that the highest level of education achievement for a person is the 10th Grade elementary school completion. 10th Grade education level An education level that indicates that the highest level of education achievement for a person is the 11th Grade elementary school completion. 11th Grade education level An education level that indicates that the highest level of education achievement for a person is the 12th Grade elementary school completion. 12th Grade education level An education level that indicates that the highest level of education achievement for a person is a degree from a 2 year college program. NCIT_C19752 C1879750 associate academic degree education level An education level that indicates that the highest level of education achievement for a person is a degree from an occupational, technical, or vocational program NCIT_C67141 C1883542 vocational program completion education level The code in the specific coding system for the payment method of the expenses incurred in a single hospitalization of the patient 患者单次住院诊疗所发生费用的支付方式的特定编码体系中的代码 Suyuan Peng, Hong Yu, Yongqun He 《电子病历基本数据集 第10部分：住院病案首页》WS 445.10-2014 NCIT_C16745 C0021672 医疗付费方式 health insurance plan A joint federal and state program that helps with medical costs for some people with limited income and resources. https://en.wikipedia.org/wiki/Medicaid Medicaid Medicare is a national health insurance program in the United States, begun in 1966 under the Social Security Administration and now administered by the Centers for Medicare and Medicaid Services (CMS). https://en.wikipedia.org/wiki/Medicare_(United_States) Medicare private health insurance plan worker compensation insurance plan body weight A body weight that is obtained immediately after birth Oliver He, Edison Ong NCIT_C76325 birth weight emergency contact phone number Yujia Tian This indicate that the individuals who deliver healthcare, supporting attribution and analysis of care delivery. care provider 1st care provider primary care provider a centrally registered identifier symobol that refers to a specific study Oliver He, Edison Ong study ID centrally registered study identifier symbol 2nd care provider secondary care provider 3rd care provider tertiary care provider An email address that is used secondary after the de fault first email address. 2nd email address A textual question about age Fred Dowd, Oliver he age question A textual question that asks whether a person's age is less than 18 years old Fred Dowd, Oliver He Whether age less than 18 years old An eligibility assessment form that is designed and used by the Kidney Precision Medicine Project (KPMP; http://kpmp.org) organization. Oliver He, Edison Ong, Fred Dowd KPMP eligibility assessment form BMI question Whether BMI greater than 40 kg/m2 Whether BMI greater than 40 kg per m2 BMI greater than 40 kg per m2 question about blood transfusion Edison Ong, Oliver He Whether unwilling to receive blood transfusion pregnancy question A pregnancy question that asks whether a person is pregnant at the moment of being questioned Fred Dowd, Oliver He Whether pregnancy occurs now Whether pregnant transplant question A transplant question that asks whether a person has received some transplant (includes solid transplant and bone marrow). Example transplants are kidney transplant and heart transplant. Fred Dowd, Oliver He Whether transplant recipient A transplant question that asks whether a person has received a kidney transplant. Fred Dowd, Oliver He Whether kidney transplant recipient KPMP clinical report form A biopsy procedure form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization. Oliver He, Fred Dowd, Edison Ong KPMP biopsy procedure form A biosample collection form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization. KPMP biosample collection form An adverse event entry form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization. KPMP adverse event entry form A biopsy safety checklist form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization. Oliver He, Fred Dowd, Edison Ong KPMP biopsy safety checklist form A clinic reception form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization. Oliver He, Edison Ong, Fred Dowd KPMP clinic reception form A contact information form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization. KPMP contact information form KPMP demographic information form KPMP health literacy questionnaire form A textual question that is about eligibility of a person to participate in a project. Edison Ong, Oliver He eligibility question KPMP AKI hospitalization form KPMP CKD hospitalization form KPMP laboratory result form KPMP medical history form Fred Dowd, Oliver He This form is the end of a successful screening process KPMP consent form KPMP medications form KPMP new patient form KPMP participant reported outcome measures form KPMP participant study status form KPMP pathology images upload form KPMP patient experience survey form KPMP personal history form KPMP physical measurement form KPMP post biopsy form KPMP tissue tracking form KPMP Dx core - .jpg images QC form KPMP Dx core - disease categories form KPMP central path quality metrics assessment Dx core form KPMP central path quality metrics assessment interrogation core form The last four digits of a social security number, which is often asked in a survey form. Oliver He last 4 digits of SSN http://en.wikipedia.org/wiki/Social_Security_number last four digits of social security number A question in a survey form may ask whether a provided email address belongs to self The self is an individual person as the object of his or her own reflective consciousness. Oliver He human self https://en.wikipedia.org/wiki/Self self A textual question about email Fred Dowd, Oliver he email question An email question that asks the exact email address What email address An email question that asks whether the email address provided belongs to the person being surveyed. Whether self owns email address An email question that asks who owns the email address. Who owns email address A textual question that asks the birthday of the person being surveyed What is your birthday The textual name of the contact person or organization contact name The textual name of the contact person or organization that will be contacted during emergency emergency contact name Who owns the 2nd email address Who owns the 3rd email address physician information physician specialty information Health care or healthcare is the maintenance or improvement of health via the prevention, diagnosis, and treatment of disease, illness, injury, and other physical and mental impairments in human beings. Oliver He healthcare https://en.wikipedia.org/wiki/Health_care health care A health care rendered for the benefit of a patient. C0017313 C15239 patient care Primary care refers to the work of health professionals who act as a first point of consultation for all patients within the health care system Oliver He https://en.wikipedia.org/wiki/Health_care#Primary_care C94340 C0033137 primary care Secondary care includes acute care: necessary treatment for a short period of time for a brief but serious illness, injury, or other health condition. This care is often found in a hospital emergency department. Secondary care also includes skilled attendance during childbirth, intensive care, and medical imaging services. Oliver He https://en.wikipedia.org/wiki/Health_care#Secondary_care secondary care Tertiary care is specialized consultative health care, usually for inpatients and on referral from a primary or secondary health professional, in a facility that has personnel and facilities for advanced medical investigation and treatment, such as a tertiary referral hospital. Oliver He https://en.wikipedia.org/wiki/Health_care#Tertiary_care tertiary care The term quaternary care is sometimes used as an extension of tertiary care in reference to advanced levels of medicine which are highly specialized and not widely accessed. Oliver He https://en.wikipedia.org/wiki/Health_care#Quaternary_care quaternary care A patient care that is provided in hospital. Oliver He https://en.wikipedia.org/wiki/Health_care#Secondary_care It is sometimes the synonym of secondary care. However, many secondary care providers, such as psychiatrists, clinical psychologists, occupational therapists, most dental specialties or physiotherapists do not necessarily work in hospitals. Some primary care services are delivered within hospitals. Depending on the organization and policies of the national health system, patients may be required to see a primary care provider for a referral before they can access secondary care. hospital care nephrology care endocrinology care physician question What is the physician's specialty? What physician's specialty hospital question What is name of clinic or hospital what name of hospital postal address question address question What street name What is the city name? What city What state What Zip code What street number and name What apartment number What apartment Which country? What country Do you have physician who provides your usual medical care? Whether have physician for usual medical care nephrologist care provider nephrology care provider patient condition question Whether diabetic kidney disease (DKD) Whether hypertensive CKD (H-CKD) Whether diabetic nephropathy resisters percutaneous biopsy Whether AKI percutaneous biopsy Whether AKI open biopsy Whether biopsy CRF filled up by patient What postal code CRF filled up by research coordinator CRF filled up by biopsy operator biopsy-related CRF post biopsy hospitlization form A clinical report form that is related to the processing and analysis of tissue of diseased patient. pathology CRF screening and patient tracking CRF enrollment CRF A eligibility question that asks whether a patient is eligible to consent to participate in a project. Oliver He, Edison Ong Whether patient eligible to consent HIPAA release Whether patient signed HIPPA release form When HIPAA release form signed Whether scanned HIPAA release form uploaded A chronic kidney disease that is accompanied with elevated blood pressure or hypertension Oliver He H-CKD https://www.nejm.org/doi/full/10.1056/NEJMoa0910975 Oliver note: This term is not shown in MONDO or DOID. May request an addition. hypertensive chronic kidney disease a process that obtains a tissue from a living body in order to discover the presence, cause, or extent of a disease, or perform further biomeidcal investigation Oliver He, Hong Yu https://en.oxforddictionaries.com/definition/biopsy https://en.wikipedia.org/wiki/Biopsy biopsy A systematized collection of patient and population electronically-stored health information in a digital format Oliver He, Edison Ong EHR EMR electronic medical record https://en.wikipedia.org/wiki/Electronic_health_record NCIT_C142529 NCIT definition: A digital version of a patient's medical history. [def-source: NCI] electronic health record A biopsy that takes a small piece of tissue out of a living body through the skin, using only a tiny incision Oliver He, Hong Yu http://www.wales.nhs.uk/sitesplus/documents/866/PIU433%284%29%28ABUHB%29%28Active%29%28JAN%2017%29.pdf percutaneous biopsy AKi percutaneous biopsy A biopsy process in which a surgical incision (cut) is made through the skin to expose and remove tissues Oliver He, Hong Yu https://en.wikipedia.org/wiki/Open_biopsy open biopsy AKI open biopsy diabetic nephropathy resisters percutaneous biopsy The state of being free from illness or injury Oliver He, Edison Ong health state https://en.oxforddictionaries.com/definition/health https://en.wikipedia.org/wiki/Health https://www.healthknowledge.org.uk/public-health-textbook/research-methods/1c-health-care-evaluation-health-care-assessment/measures-health-status health status The medical state or condition of a patient Oliver He, Edison Ong medical state https://en.wikipedia.org/wiki/Medical_state medical condition Whether diseased Whether kidney diseased the date or time on which a visit occurs Oliver He clinical visit date visit time NCIT_C83031 C1320303 visit temporal region a machine-readable centrally registered identifier that is represented in a visual format on a surface bar code https://en.wikipedia.org/wiki/Barcode barcode a barcode that represents a specific specimen specimen barcode A planned process that tracks the tissue specimen including tissue vial number, storage location, time of vial arrival to storage, storage temperature, etc. Oliver He, Edison Ong tissue tracking A centrally registered identifier that is assigned for a specific clinical trial registered in the ClinicalTrials.gov. The format for the ClinicalTrials.gov registry number is “NCT” followed by an 8-digit number, e.g.: NCT00000419. Qingliang Leon Li, Asiyah Yu Lin, Oliver He NCT identifier NCT number National Clinical Trial identifier https://clinicaltrials.gov/ct2/about-site/link-to https://www.nlm.nih.gov/bsd/policy/clin_trials.html USA National Clinical Trial identifier A textual entity that is the title of a clinical trial https://prsinfo.clinicaltrials.gov/definitions.html title of clinical trial A title of clinical trial that is recorded as official https://prsinfo.clinicaltrials.gov/definitions.html official title of clinical trial A title of clinical trial that is meant for lay people understanding https://prsinfo.clinicaltrials.gov/definitions.html lay title of clinical trial A person who performs an investigation task and takes the role of an investigator role. Leon Li, Oliver He, Asiyah Lin https://prsinfo.clinicaltrials.gov/definitions.html investigator An investigator who is involved in a clinical trial and is responsible for ensuring that an investigation is conducted according to the signed investigator statement, the investigational plan, and applicable regulations; for protecting the rights, safety, and welfare of subjects under the investigator's care; and for the control of drugs under investigation. Oliver He https://en.wikipedia.org/wiki/Clinical_investigator clinical investigator The date on which a study starts study start date The (estimated) date on which the clinical study is open for recruitment of participants, or the actual date on which the first participant is enrolled. https://prsinfo.clinicaltrials.gov/definitions.html clinical trial start date The date on which a study completes Oliver He study completion date The date the final participant was examined or received an intervention for purposes of final collection of data for the primary and secondary outcome measures and adverse events (for example, last participant’s last visit), whether the clinical study concluded according to the pre-specified protocol or was terminated. https://prsinfo.clinicaltrials.gov/definitions.html clinical trial study completion date The date that the final participant was examined or received an intervention for the purposes of final collection of data for the primary outcome, whether the clinical study concluded according to the pre-specified protocol or was terminated. In the case of clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all of the primary outcomes. https://prsinfo.clinicaltrials.gov/definitions.html clinical trial primary completion date The main objective of the intervention(s) being evaluated by the clinical trial. primary purpose of clinical trial https://prsinfo.clinicaltrials.gov/definitions.html clinical trial primary purpose specification a date when a registration occurs date of registration A primary outcome measure used to describe patterns of diseases or traits or associations with exposures, risk factors or treatment. primary outcome https://prsinfo.clinicaltrials.gov/definitions.html primary health outcome measurement datum The current stage of a clinical study and whether it is or will be open for enrollment Oliver He https://clinicaltrials.gov/ct2/help/glossary/recruitment-status recruitment status A case report form that is presented in an electronic format Fred Dowd, Oliver He eCRF https://en.wikipedia.org/wiki/Case_report_form#eCRF electronic case report form A human being who is a candidate to participant in a clinical study Fred Dowd, Oliver He clinical study participant candidate answering textual question a date of the present date Oliver He, Edison Ong today's date CRF filled up by participant candidate Fred Dowd, Edison Ong, Oliver He pregnancy test positive Fred Dowd, Edison Ong, Oliver He hemoglobin test finding Fred Dowd, Edison Ong, Oliver He In KPMP, the hemoglobin < 9 g/dl is considered as hemoblobin test positive. hemoglobin test positive with result < 9 g/dl a date when a test is performed at the first time Oliver He, Edison Ong date of first test a date when a test is performed Oliver He, Edison Ong date of test a date when a test is performed at the second time Oliver He, Edison Ong date of second test A person name that includes both the first and last name Edison Ong, Oliver He first and last name human first and last name person first and last name A date when a document is signed Oliver He, Edison Ong sign date Oliver He, Edison Ong status The current stage of a clinical study and whether it is or will be open for enrollment Oliver He https://clinicaltrials.gov/ct2/help/glossary/recruitment-status study status Oliver He, Edison Ong patient status a selection criterion (rule) which defines and states the exclusion condition for an entity to be considered as suitable for a given task or participation in a process. Oliver He, Edison Ong https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044655/ Replace by a corresponding OBI term obsolete exclusion criterion true An exclusion criterion that relates to the process of bleeding Oliver He, Edison Ong bleeding exclusion criteria A case report form of PROMIS: Patient-Reported Outcomes Measurement Information System. PROMIS is a set of person-centered measures that evaluates and monitors physical, mental, and social health in adults and children. It can be used with the general population and with individuals living with chronic conditions. Fred Dowd, Edison Ong, Oliver He Patient-Reported Outcome Measures form http://www.healthmeasures.net/explore-measurement-systems/promis PROMIS form kit identifier A centrally registered identifier that is for a kit used in biopsy Fred Dowd, Edison Ong, Oliver He biopsy kit identifier A PROMIS form that is designed and used by the KPMP project (http://kpmp.org). Oliver He KPMP PROMIS form A biopsy attempt Fred Dowd, Edison Ong, Oliver He biopsy pass A biopsy that uses needle Fred Dowd, Edison Ong, Oliver He needle biopsy A textual question about health condition Oliver He, Edison Ong health status question A health status question that asks about the condition of a person's heath, which can be a selection from different options such as Excellent, Very good, Good, Fair, or Poor. Oliver He, Edison Ong what health status excellent health status very good health status good health status fair health status poor health status quality of life excellent quality of life very good quality of life good quality of life fair quality of life poor quality of life consent status A consent status that indicates a participant unwilling to receive a procedure of blood transfusion Edison Ong, Oliver He unwilling to receive a blood transfusion A consent status that indicates a participate willing to receive a procedure of blood transfusion Edison Ong, Oliver He willing to receive a blood transfusion year A textual quesition thta is about medical history of a person medical history question What birth weight Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://pubchem.ncbi.nlm.nih.gov/source/NIPH%20Clinical%20Trials%20Search%20of%20Japan https://rctportal.niph.go.jp/en/ Japan clinical trial identifier A Japan clinical trial identifier provided by the University Hospital Medical Information Network Center (UMIN-CTR) Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://rctportal.niph.go.jp/en/ UMIN-CTR clinical trial identifier Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://rctportal.niph.go.jp/en/ JAPIC clinical trial identifier Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://rctportal.niph.go.jp/en/ JMACCT clinical trial identifier EudraCT Number: 2007-002422-29 Qingliang Leon Li, Asiyah Yu Lin, Oliver He EudraCT identifier https://en.wikipedia.org/wiki/EudraCT https://www.clinicaltrialsregister.eu/ctr-search/search https://www.clinicaltrialsregister.eu/ctr-search/search?query=eudract European clinical trial registry identifier A clinical trial that covers both Phase 1 and 2 Leon Li, Asiyah Lin, Oliver He https://en.wikipedia.org/wiki/Clinical_trial Phase I/II clinical trial Leon Li, Asiyah Lin, Oliver He combinational intervention The quality of a clinical trial that studies a drug or biological product. The phase is based on the study's objective, the number of participants, and other characteristics. According to USA FDA, there are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Leon Li, Asiyah Lin, Oliver He clinical trial stage https://www.clinicaltrials.gov/ct2/help/glossary/phase clinical trial phase A clinical trial phase that represents the first-in-man trial, which tests within a small group of people (typically 20-80) to evaluate safety, determine safe dosage ranges, and begin to identify side effects. A drug's side effects could be subtle or long term, or may only happen with a few people, so phase 1 trials are not expected to identify all side effects. Leon Li, Asiyah Lin, Oliver He Phase 1 Phase I http://purl.obolibrary.org/obo/NCIT_C15600 https://en.wikipedia.org/wiki/Clinical_trial C0920321 C15600 clinical trial phase 1 A clinical trial phase that is designed to study a biomedical or behavioral intervention in a larger group of people (several hundred), to evaluate the drug's effectiveness for a particular indication in patients with the disease or condition under study, and to determine the common short-term side effects and risks associated with the intervention. [def-source: NCI] Leon Li, Asiyah Lin, Oliver He Phase II http://purl.obolibrary.org/obo/NCIT_C15601 https://en.wikipedia.org/wiki/Clinical_trial C0282460 C15601 clinical trial phase 2 A clinical trial phase that is designed to investigate the efficacy of the biomedical or behavioral intervention in large groups of human subjects (from several hundred to several thousand), to confirm efficacy, to monitor adverse reactions to the new medication or treatment regimen with respect to long-term use and by comparing the intervention to other standard or experimental interventions as well as to a placebo. [def-source: NCI] Leon Li, Asiyah Lin, Oliver He Phase III http://purl.obolibrary.org/obo/NCIT_C15602 https://en.wikipedia.org/wiki/Clinical_trial C0282461 C15602 clinical trial phase 3 A clinical trial phase that is designed for a randomized, controlled trial to evaluate the long-term safety and efficacy of a drug for a given indication. Often they are designed to study side effects that may have become apparent after the phase III study was completed. [def-source: NCI] Leon Li, Asiyah Lin, Oliver He Phase IV https://en.wikipedia.org/wiki/Clinical_trial C0282462 C15603 clinical trial phase 4 A clinical trial phase that is designed to use an investigational agent that is available only in very limited quantities and which has never previously given to humans or for which there is extremely limited human experience. Phase 0 clinical trials are intended to enable researchers to understand the path of the drug in the body and its efficacy. Adverse event reporting in Phase 0 trials is expedited. [def-source: NCI] Leon Li, Asiyah Lin, Oliver He Early Phase 1 Pre-Clinical Phase clinical trial phase 0 http://purl.obolibrary.org/obo/NCIT_C54721 https://en.wikipedia.org/wiki/Clinical_trial C1882358 C54721 clinical trial early phase 1 A clinical trial that covers both Phase 2 and 3 Leon Li, Asiyah Lin, Oliver He https://en.wikipedia.org/wiki/Clinical_trial Phase II/III clinical trial Leon Li, Asiyah Lin, Oliver He radiation procedure radiation Leon Li, Asiyah Lin, Oliver He genetic intervention A medical intervention that involves a behavioral process to control, prevent, or treat a behavior problem. Leon Li, Asiyah Lin, Oliver He https://www.understood.org/en/learning-attention-issues/treatments-approaches/educational-strategies/behavior-intervention-plans-what-you-need-to-know behavioral intervention ImmPort study accession: SDY269 Edison Ong, Oliver He study accession study accession identifier Edison Ong, Oliver He title of investigation title of study A livinging individual who is or becomes a participant in research, either as a recipient of a test article or as a control. A subject may be either a healthy human or a patient. Based on the NIH definition, a living individual about whom an investigator (whether professional or student) conducting the following research: (1) Obtains information or biospecimens through intervention or interaction with the individual, and uses, studies, or analyzes the information or biospecimens; or (2) Obtains, uses, studies, analyzes, or generates identifiable private information or identifiable biospecimens. Oliver He, Anthony Huffman https://grants.nih.gov/policy/humansubjects/research.htm https://irb.research.chop.edu/who-human-subject https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ human subject In clinicaltrials.gov, contact information character limits: First Name: 62 characters Last Name: 62 characters Degree: 30 characters Phone: 30 characters Phone Ext: 14 characters Email: 254 characters Citation: https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials A person who serves as a contact role and has disclosed specified information to be reached. Usually the contact information, such as email and phone number, is provided., Leon, Asiyah, Oliver: Since each contact needs to provide some contact information, we may need to define the contact information. Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials contact person A contact person for each facility participating in a study. Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html facility contact biosample identifier GSM identiifier ImmPort biosample identifier Person to contact if Facility Contact is not available (that is, a second contact person). Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials facility contact backup Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials contact of scientific queries An investigation agent role that is taken by a human individual Leon Li, Asiyah Lin, Oliver He human investigator role investigator role a role taken by a person who serves as a contact for some process. Leon Li, Asiyah Lin, Oliver He contact person role Topical ocular hypotensive eye drops Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials contact for public queries A person who is responsible for the overall scientific leadership of the protocol, including study principal investigator Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials overall study official A person to whom questions concerning enrollment at any location of the study can be addressed. Leon Li, Asiyah Lin, Oliver He central contact person https://prsinfo.clinicaltrials.gov/definitions.html central contact person of study A person to contact if Central Contact is not available. Leon Li, Asiyah Lin, Oliver He central contact person https://prsinfo.clinicaltrials.gov/definitions.html central contact backup of study information content entity about a contact person Leon Li, Asiyah Lin, Oliver He contact person information A sponsor role taken by an individual, organization, group or other legal entity which takes responsibility for initiating, managing and/or financing a study. The Primary Sponsor is responsible for ensuring that the trial is properly registered. The Primary Sponsor may or may not be the main funder. Leon Li, Asiyah Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ primary sponsor role A sponsor role taken by an additional individual, organization or another legal person, if any, that has agreed with the primary sponsor to take on responsibilities of sponsorship. Leon Li, Asiyah Lin, Oliver He collaborator role https://www.who.int/ictrp/network/trds/en/ A secondary sponsor may have agreed to: - take on all the responsibilities of sponsorship jointly with the primary sponsor; or - form a group with the Primary Sponsor in which the responsibilities of sponsorship are allocated among the members of the group; or - act as the Primary Sponsor’s legal representative in relation to some or all of the trial sites. by WHO (https://www.who.int/ictrp/network/trds/en/) In clinicaltrials.gov, the secondary sponsor role can be taken by a project collaborator (Reference: https://prsinfo.clinicaltrials.gov/trainTrainer/WHO-ICMJE-ClinTrialsgov-Cross-Ref.pdf). However, a secondary sponsor may serve as a collaborator role, but a collaborator may not serve as a secondary sponsor role. secondary sponsor role An investigator role taken by an individual who is designated as responsible party by the sponsor Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html principal investigator role An investigator role taken by an individual who both initiates and conducts the study Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html sponsor investigator role An investigation agent role taken by an agent (an individual, organization, group or another legal entity) who provides support to an investigation. The support may include funding, design, implementation, data analysis or reporting. The responsible party is responsible for confirming all collaborators before listing them. Leon Li, Asiyah Li, Oliver He collaborator role https://prsinfo.clinicaltrials.gov/definitions.html#Collaborators https://www.who.int/ictrp/network/trds/en/ A secondary sponsor may serve as a collaborator role. However, a collaborator may not serve as a secondary sponsor role. investigation collaborator role a selection criterion (rule) which defines and states the inclusion condition for an entity to be considered as suitable for a given task or participation in a process. Oliver He, Edison Ong, Leon Li, Asiyah Lin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044655/ Replace by a corresponding OBI term obsolete inclusion criterion true A centrally registered unique identifier assigned by the primary registry to a study including a clinical trial. Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ primary registry identifier An individual, organization, group or other legal entity that involves with any of the following activities: initiating, managing and funding a study Leon Li, Asiyah Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ NCIT_C48355 sponsor investigation agent The individual, organization, group or other legal entity which takes responsibility for initiating, managing and/or financing a study. In clinical trial, the Primary Sponsor is responsible for ensuring that the trial is properly registered. The Primary Sponsor may or may not be the main funder. Leon Li, Asiyah Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ primary sponsor An additional individual, organization or another legal person, if any, that has agreed with the primary sponsor to take on responsibilities of sponsorship. Leon Li, Asiyah Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ A secondary sponsor may have agreed to: - take on all the responsibilities of sponsorship jointly with the primary sponsor; or - form a group with the Primary Sponsor in which the responsibilities of sponsorship are allocated among the members of the group; or - act as the Primary Sponsor’s legal representative in relation to some or all of the trial sites. Reference: https://www.who.int/ictrp/network/trds/en/ secondary sponsor A centrally registered unique identifier besides the primary registry identifier allocated by the Primary Registry, if any. Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ secondary registry identifier An agent (an individual, organization, group or another legal entity) who provides support to an investigation. The support may include funding, design, implementation, data analysis or reporting. The responsible party is responsible for confirming all collaborators before listing them. Leon Li, Asiyah Li, Oliver He investigation collaborator https://prsinfo.clinicaltrials.gov/definitions.html#Collaborators https://www.who.int/ictrp/network/trds/en/ collaborator An investigator who is designated as responsible party by the sponsor Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html principal investigator An investigator who both initiates and conducts the study. Leon Li, Asiyah Lin, Oliver He https://prsinfo.clinicaltrials.gov/definitions.html sponsor investigator A role taken by a string (which may have mixed integer and text) that serves as a unique record. Leon Li, Asiyah Lin, Oliver He identifier role An identifier role that inheres in a unique record which provides an identifier secondary to the primary registry identifier. Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ secondary registry identifier role An identifier role that is assigned by a primary registry and provides a unique record. Qingliang Leon Li, Asiyah Yu Lin, Oliver He https://www.who.int/ictrp/network/trds/en/ primary registry identifier role a human who is a recipient of a health care service performed by healthcare professionals. human patient https://en.wikipedia.org/wiki/Patient Hong Yu, Oliver He patient A systematic, scientific investigation that can be either interventional or observational and involves human beings as research subjects. Human subject research can be either medical (clinical) research or non-medical (e.g., social science) research. Oliver He human investigation human study https://en.wikipedia.org/wiki/Human_subject_research human subject study A collection of humans who share a defining characteristic, typically those who are collectively experiencing a common event (e.g., a clincal trial study) in a selected period. Anthony Huffman, Oliver He https://en.wikipedia.org/wiki/Cohort_study human cohort A material entity that is composed of organic structure and is capable of self-replication (with or without host support). Various types of self-replicating organic structures can be found at: https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures. Oliver He organic self-replicating system https://en.wikipedia.org/wiki/Self-replication https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496545/ self-replicating organic structure A self-replicating organic structure that is composed of one cell or multiple cells and embodies the properties of life. Oliver He cellular self-replicating organic structure organism https://en.wikipedia.org/wiki/Organism cellular organism A self-replicating organic structure that does not have the unit of cell but it may use the cells to replicate. Oliver He non-cellular self-replicating organic structure non-organism self-replicating organic structure https://en.wikipedia.org/wiki/Self-replication acellular self-replicating organic structure An non-organism infectious agent that is composed solely of a short strand of circular, single-stranded RNA and has no protein coating. Oliver He https://en.wikipedia.org/wiki/Mobile_genetic_elements https://en.wikipedia.org/wiki/Viroid viroid A process of a dynamic system that produces an identiical or similar copy of itself. Oliver He https://en.wikipedia.org/wiki/Self-replication self-replication organic chemical entity A measurement datum that is about the age of human subject Oliver He, Jie Zheng, Anthony Huffman https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ human subject age data For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, a child is defined as an individual under the age of 18 years. Oliver He, Jie Zheng, Anthony Huffman child human subject https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ child age data of human subject (by NIH) The regular aged adult group is defined here as an individual over 18 years of age. Oliver He, Jie Zheng, Anthony Huffman adult human subject https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ adult age data of human subject For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, an older adult is defined as an individual 65 years of age or older. Oliver He, Jie Zheng, Anthony Huffman older adult human subject https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ older adult data of human subject (by NIH) The representation of a positive conclusion of a diagnostic process, which indicates that the patient is diagnozed as positive for a hypothetic disease. Oliver He 阳性诊断 positive diagnosis The representation of a negative conclusion of a diagnostic process, which indicates that the patient is diagnozed as negative for a hypothetic disease. Oliver He 阴性诊断 negative diagnosis The representation of a presumptive positive conclusion of a diagnostic process, which indicates that the patient is diagnozed as presumptive positive for a hypothetic disease. Oliver He 假定阳性诊断 疑是诊断 presumptive positive diagnosis A human subject classified as adult, which is defined by NIH as an individual under the age of 18 years. For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, a child is defined as an individual under the age of 18 years. Oliver He https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ child human subject A human subject classified as adult, which is defined by NIH as an individual 65 years of age or older. For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, an older adult is defined as an individual 65 years of age or older. Oliver He https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ older adult human subject A human subject classified as adult, which is defined by NIH as an individual over 18 years of age. Oliver He https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/ adult human subject Yingtong Liu, Anthony Huffman, Oliver He biomarker role Anthony Huffman, Oliver He immune signature role Anthony Huffman, Oliver He cytokine signature role Anthony Huffman, Oliver He inflammatory cytokine signature role A material entity that has a measurable quality or process profile(s), which can be used as an indicator of an underlying biological state or identity. The NIH Biomarkers and Surrogate Endpoint Working Group defined a biomarker as “A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention” (https://pubmed.ncbi.nlm.nih.gov/11240971/). However, the definition of 'characteriistc' is unclear, so we do not use the exact definintion in the ontology. Yingtong Liu, Anthony Huffman, Oliver He https://en.wikipedia.org/wiki/Biomarker https://en.wikipedia.org/wiki/Biomarker_(cell) https://en.wikipedia.org/wiki/Biomarker_(medicine) biomarker Anthony Huffman, Oliver He A biomarker that is indicative of an immune response https://pubmed.ncbi.nlm.nih.gov/22072636/ https://pubmed.ncbi.nlm.nih.gov/32286245/ immune biomarker Anthony Huffman, Oliver He cytokine biomarker Anthony Huffman, Oliver He inflammatory cytokine biomarker Yingtong Liu, Anthony Huffman, Oliver He disease biomarker role A biomarker that is indicative of a disease Yingtong Liu, Anthony Huffman, Oliver He https://en.wikipedia.org/wiki/Biomarker_(medicine) disease biomarker A biomarker that is an indicator of a cell lineage or cell type Yingtong Liu, Anthony Huffman, Oliver He cell marker cell type marker https://en.wikipedia.org/wiki/Biomarker_(medicine) cell lineage biomarker Oliver He, Yingtong Liu https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers molecular biomarker Cellular biomarkers are marked cells that can be isolated, sorted, quantified and characterized by their morphology and physiology, and used in both clinical and laboratory settings for different biomarker applications. An example of a cellular biomarker sorting technique is Fluorescent-activated cell sorting. Oliver He, Yingtong Liu https://en.wikipedia.org/wiki/Biomarker https://en.wikipedia.org/wiki/Biomarker_(cell)#Cellular_Biomarkers cellular biomarker Oliver He, Yingtong Liu https://en.wikipedia.org/wiki/Biomarker https://en.wikipedia.org/wiki/Biomarker_(cell)#Imaging_Biomarkers imaging biomarker A biomarker that can predict clincal outcome. Oliver He, Yingtong Liu https://en.wikipedia.org/wiki/Biomarker predictive biomarker A biomarker that provides information about the patient's overall outcome, regardless of therapy. Oliver He, Yingtong Liu https://en.wikipedia.org/wiki/Biomarker prognostic biomarker A biomarker that can serve a role in narrowing down diagnosis, which can lead to diagnosis that is significantly more specific to individual patients. Oliver He, Yingtong Liu https://en.wikipedia.org/wiki/Biomarker diagnostic biomarker A molecular biomarker at the DNA gene level Oliver He, Yingtong Liu genomic biomarker https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers DNA biomarker A molecular biomarker at the RNA level Oliver He, Yingtong Liu transcriptomic biomarker https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers RNA biomarker A molecular biomarker at the protein level Oliver He, Yingtong Liu proteomic biomarker https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers protein biomarker A biomarker that is indicative of a disease and achieved through imaging. https://en.wikipedia.org/wiki/Biomarker_(medicine)#Imaging_disease_biomarkers_by_magnetic_resonance_imaging_(MRI) imaging disease biomarker A disposition that a material entity (e.g., gene or protein) is susceptible to be up or down-regulated in an organism or virus. Oliver He, Anthony Huffman susceptibility to biological regulation Oliver He imaging disease biomarkers by magnetic resonance imaging https://en.wikipedia.org/wiki/Biomarker_(medicine)#Imaging_disease_biomarkers_by_magnetic_resonance_imaging_(MRI) imaging disease biomarkers by MRI Oliver He A biomarker that is indicative of the presence of cancer in the body https://en.wikipedia.org/wiki/Cancer_biomarker cancer marker A disposition that a material entity (e.g., gene or protein) is susceptible to be up-regulated in an organism or virus. Oliver He, Anthony Huffman susceptibility to biological up-regulation A disposition that a material entity (e.g., gene or protein) is susceptible to be down-regulated in an organism or virus. Oliver He, Anthony Huffman susceptibility to biological down-regulation A Unified Social Credit Identifier is issued to registered companies and other types of organization by the Chinese government. Suyuan Peng, Hong Yu, Oliver He https://en.wikipedia.org/wiki/Unified_Social_Credit_Identifier 组织机构代码 Unified Social Credit Identifier Suyuan Peng, Hong Yu, Oliver He health care organization https://www.sciencedirect.com/topics/nursing-and-health-professions/health-care-organization 医疗机构 healthcare organization A centrality registered identifier for a medical record. Suyuan Peng, Hong Yu, Oliver He medical record ID https://en.wikipedia.org/wiki/Medical_record 病案号 medical record number A centrally registered identifier that is uniquely assigned to a person. Oliver He, Long Tran https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:person person ID 指患者在本医疗机构住院诊治的次数 Suyuan Peng, Hong Yu, Oliver He 《卫生部关于修订住院病案首页的通知》卫医政发〔2011〕84号 住院次数 number of hospital admissions A time measurement datum that is about a human being who bears a patient role and specifies the date of the patient's admission to a hospital 指患者实际入病房的接诊时间 Suyuan Peng, Hong Yu, Oliver He http://purl.obolibrary.org/obo/EUPATH_0000319 《住院病案首页数据填写质量规范（暂行）》国卫办医发〔2016〕24号 入院时间 date of hospital admission A year when an organism (e.g., a human) is born. Oliver He, Long Tran https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:person year of birth A month when an organism (e.g., a human) is born. Oliver He, Long Tran https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:person month of birth The date and time of birth of a person. Oliver He, Long Tran https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:person https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:single-page This term is generated to be equivalent to the "birth_datetime" in OMOP. Also note: in OMOP v6.0, DATETIME fields were made mandatory and date fields were made optional. Reference: https://ohdsi.github.io/CommonDataModel/cdm60.html#PERSON birth datetime A time measurement datum that is about a human being who bears a patient role and specifies the date of the patient's discharge from a hospital 出院时间是指患者治疗结束或终止治疗离开病房的时间，其中死亡患者是指其死亡时间；记录时间应当精确到分钟 Suyuan Peng, Hong Yu, Oliver He http://purl.obolibrary.org/obo/EUPATH_0000320 《住院病案首页数据填写质量规范（暂行）》国卫办医发〔2016〕24号 入院时间 date of hospital discharge The number of health card for residents of the People's Republic of China 在已统一发放“中华人民共和国居民健康卡”的地区填写健康卡号码，尚未发放“健康卡”的地区填写“-” Suyuan Peng, Hong Yu, Yongqun He 《卫生部关于修订住院病案首页的通知》卫医政发〔2011〕84号 健康卡号 residents health card number time that is related to the birth Oliver He, Long Tran time of birth birth-related time A care site is a uniquely identified institutional (physical or organizational) unit where healthcare delivery is practiced, for example, office, ward, hospital, clinic, etc. Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#CARE_SITE http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON https://en.wikipedia.org/wiki/Health_care According to OMOP, care site does not consider the provider (human) information such a specialty. Instead, care site is considered at the institutional level. care site A centrally registered identifier that refers to where the care provider typically provides the primary care. Oliver He, Long Tran care site id http://ohdsi.github.io/CommonDataModel/cdm54.html#CARE_SITE http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON care site identifier A medical occurrence where a person engages with the healthcare system for a duration of time. Oliver He, Long Tran visit occurrence http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE medical visit A centrally registered identifier that refers to a specific visit occurrence. This identifier identifies a unique interaction between a person and the health care system. Oliver He, Long Tran visit occurrence id http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE visit occurrence identifier A vist ocurrence in which the patient's condition requires admission to a hospital. Oliver He, Long Tran inpatient visit occurrence http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Inpatient_care inpatient visit A vist ocurrence in which a patient attends an outpatient clinic with no plan to stay beyond the duration of the visit. Oliver He, Long Tran outpatient visit occurrence http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients outpatient visit A vist ocurrence in which a patient visits an emergeny room with no plan to stay beyond the duration of the visit. Oliver He, Long Tran ER visit http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients emergency room visit The date on which a visit starts. In the case of an inpatient visit this should be the date the patient was admitted to the hospital or institution. In all other cases this should be the date of the patient-provider interaction. Oliver He, Long Tran clinical visit start date http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE visit start date The date on which a visit ends. For inpatient visits the end date is typically the discharge date. If a Person is still an inpatient in the hospital at the time of the data extract and does not have a visit_end_date, then set the visit_end_date to the date of the data pull. Oliver He, Long Tran clinical visit end date http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE visit end date A temporal region that covers the time period from the visit start time to the visit end time. Oliver He, Long Tran visit duration The date and time on which a visit starts. In the case of an inpatient visit this should be the date the patient was admitted to the hospital or institution. In all other cases this should be the date of the patient-provider interaction. Oliver He, Long Tran clinical visit start datetime http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE visit start datetime The date and time on which a visit ends. For inpatient visits the end date is typically the discharge date. If a Person is still an inpatient in the hospital at the time of the data extract and does not have a visit_end_date, then set the visit_end_date to the date of the data pull. Oliver He, Long Tran clinical visit end datetime http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE visit end datetime A visit occurrence that occurs for the person prior to the given visit. There could be a few days or a few years in between. Oliver He, Long Tran preceding visit preceding visit occurrence http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE preceding medical visit A vist ocurrence that includes a visit to the emergency room followed by a subsequent inpatient visit. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients emergency room and inpatient visit A visit to a dedicated institution for reasons of poor health, at a Care Site, long-term or permanently, with no physician but possibly other Providers permanently available to deliver service around the clock Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients non-hospital institution visit A visit where a provider visits a person, without a care site, within one day, delivering service Oliver He, Long Tran home visit http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients home medical visit A visit in which a patient engages with a Provider through communication media. A patient can use digital information and communication technologies, such as computers and mobile devices, to access health care services remotely and manage their health care. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients telehealth visit A visit to the pharmacy for dispensing of drug, at a care site, within one day Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients pharmacy visit A visit to a dedicated institution, at a care site, within one day, for the purpose of a measurement. The visit is carried out in a medical laboratory or clinical laboratory where tests are carried out on clinical specimens to obtain information about the health of a patient to aid in diagnosis, treatment, and prevention of disease Oliver He, Long Tran laboratory clinical visit laboratory visit http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients laboratory medical visit A medical visit occurrence that involves an interaction with the healthcare system, without a care site, within a day, with no providers involved, for the administrative purpose of patient case management. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients case management visit A site that is used as a permanent or semi-permanent residence for one or many humans. Long Tran, Oliver He https://en.wikipedia.org/wiki/Home home A centrally registered identifier that refers to the National Provider Number issued to health care providers in the US by the Centers for Medicare and Medicaid Services (CMS). NPI is assigned for use in all administrative and financial transactions specified by HIPAA. Oliver He, Long Tran National Providier Number http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON http://purl.obolibrary.org/obo/NCIT_C54633 National Provider Identifier A centrally registered identifier that is issued by the Drug Enforcement Administration (DEA), a US federal agency, that allows a provider to write prescriptions for controlled substances. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON https://en.wikipedia.org/wiki/Drug_Enforcement_Administration DEA identifier A medicl occurrence that is ordered by, or carried out by, a healthcare provider on a patient with a diagnostic or therapeutic purpose. Oliver He, Long Tran procedure occurrence https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE medical procedure occurrence A centrally registered identifier that refers to a procedure occurrence, which is an activity or process that is ordered by, or carried out by, a healthcare provider on a patient with a diagnostic or therapeutic purpose. Oliver He, Long Tran procedure occurrence ID https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE procedure occurrence identifier A temporal region that is associated with a procedure Long Tran, Oliver He procedure time http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE procedure temporal region The date when a procedure starts Long Tran, Oliver He procedure date http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE procedure start date The date and time when a procedure starts Long Tran, Oliver He procedure date http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE procedure start datetime The date when a procedure ends Long Tran, Oliver He procedure date http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE procedure end date The date and time when a procedure ends Long Tran, Oliver He procedure date http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE procedure end datetime The information content entity that represents the origin of record such as the clinical form as the origin record of death. Oliver He, Long Tran type concept https://github.com/OHDSI/Vocabulary-v5.0/wiki/Vocab.-TYPE_CONCEPT provenance of record As part of the OMOP CDM, PROCEDURE TYPE CONCEPT best represents the provenance of the record, for example whether it came from an EHR record or billing claim. If a procedure is recorded as an EHR encounter, the PROCEDURE_TYPE_CONCEPT would be ‘EHR encounter record’. A provenance of record that determines the provenance of the Procedure record, as in whether the procedure was from an EHR system, insurance claim, registry, or other sources. Long Tran, Oliver He Procedure Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE provenance of procedure record The status of being diagnosed as death Oliver He, Long Tran death diagnosis https://athena.ohdsi.org/search-terms/terms/32895 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status death diagnosis status OMOP4976965 A provenance of record that designates the source (provenance) of the cost data. Long Tran, Oliver He Cost Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#COST provenance of cost record As part of the OMOP CDM, use the type concept that be reflects the source of the death record. It is possible that an administrative claims database would source death information from a government file so do not assume the Death Type is the same as the Visit Type, etc. A provenance of record that determines the provenance of the death record, i.e., where it came from. Long Tran, Oliver He Death Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#DEATH provenance of death record A provenance of record that determines the provenance of the record, as in whether the record is from administrative claims or EHR. Long Tran, Oliver He Device Exposure Type Concept Device Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE provenance of device record As part of the OMOP CDM, choose the drug_type_concept_id that best represents the provenance of the record, for example whether it came from a record of a prescription written or physician administered drug. A provenance of record that determines the provenance of a drug prescription, which delineates prescriptions written, prescriptions dispensed, medication history, patient-reported exposure, etc. Long Tran, Oliver He Drug Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE provenance of drug record A provenance of record that determines the provenance of the Episode record, as in whether the procedure was from an EHR system, insurance claim, registry, or other sources. Long Tran, Oliver He Procedure Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#EPISODE provenance of episode record A provenance of record that determines the provenance of the Measurement record, as in whether the procedure was from an EHR system, insurance claim, registry, or other sources. Long Tran, Oliver He Measurement Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT provenance of measurement record As part of the OMOP CDM, the provenance of the notes most likely will be EHR. A provenance of record that determines the provenance of the note. Long Tran, Oliver He Note Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#NOTE provenance of note record A provenance of record that determines the provenance of the Observation record, as in whether the measurement was from an EHR system, insurance claim, registry, or other sources. Long Tran, Oliver He Observation Period Type Concept Observation Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#OBSERVATION provenance of observation record A provenance of record that determines the source of the specimen record, as in an EHR system. Long Tran, Oliver He Specimen Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#SPECIMEN provenance of specimen record As part of the OMOP CDM, populate this field based on the provenance of the visit record, as in whether it came from an EHR record or billing claim. A provenance of record that determines the provenance of the visit record, or where the record comes from. Long Tran, Oliver He Visit Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE provenance of visit record A provenance of record that determines the provenance of the Condition record, as in whether the condition was from an EHR system, insurance claim, registry, or other sources. Long Tran, Oliver He Condition Occurrence Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE provenance of condition occurrence record The primary diagnosis refers to the patient condition that demands the most provider resources during the patient’s stay. Oliver He, Long Tran primary diagnosis https://athena.ohdsi.org/search-terms/terms/32902 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://www.definitivehc.com/resources/glossary/primary-diagnosis There is often confusion surrounding primary and principal diagnoses and, consequently, the terms are commonly used interchangeably. While these can be (and frequently are) the same diagnosis in practice, their definitions are distinct. While a principal diagnosis is the underlying cause of patient symptoms, the primary diagnosis is used for healthcare billing purposes. Reference: https://www.definitivehc.com/resources/glossary/primary-diagnosis primary diagnosis status OMOP4976972 A medicl occurrence where a person presents a disease or medical condition stated as a diagnosis, a sign, or a symptom, which is either observed by a Provider or reported by the patient. Oliver He, Long Tran condition occurrence medical condition occurrence https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE medical condition occurrence the date or time on which a condition occurs Oliver He, Long Tran clinical condition date condition time https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE condition temporal region The date on which a condition ends. Oliver He, Long Tran clinical condition end date https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE condition end date The date and time on which a clinical condition ends. Oliver He, Long Tran clinical condition end datetime https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE condition end datetime The date on which a condition starts. Oliver He, Long Tran clinical condition start date https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE condition start date The date and time on which a condition starts. Oliver He, Long Tran clinical condition start datetime https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE In OMOP CDM, most often data sources do not have the idea of a start date for a condition. Rather, if a source only has one date associated with a condition record it is acceptable to use that date for both the CONDITION_START_DATE and the CONDITION_END_DATE. Reference: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE condition start datetime The state or status at the point during the visit the diagnosis was given (admitting diagnosis, final diagnosis), whether the diagnosis was determined due to laboratory findings, if the diagnosis was exclusionary, or if it was a preliminary diagnosis, among others. Oliver He, Long Tran diagnosis status https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://build.fhir.org/ig/HL7/UTG/CodeSystem-condition-clinical.html https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE In OPMI, we treated medical condition status as a status, which is a realizable entitry. One major section of the branch is various diagnosis condition status. There are basically two types of diagnosis: one type diagnosis is treated as a condition status, the other is diagnosis (OGMS_0000073) as a type of clinical data item. One good example to illustrate the difference is the difference between primary and principal diagnoses. While these can be (and frequently are) the same diagnosis in practice, their definitions are distinct. While a principal diagnosis is the underlying cause of patient symptoms, the primary diagnosis is used for healthcare billing purposes and is a type of medical condition status. Reference: https://www.definitivehc.com/resources/glossary/primary-diagnosis medical condition status An action specification that indicates why a Condition is no longer valid with respect to the purpose specified within the source data. Oliver He, Long Tran https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE In OMOP CDM, a Stop Reason does not necessarily imply that the condition is no longer occurring. medical condition stop reason specification The status of have the primary admission diagnosis Oliver He, Long Tran primary admission diagnosis https://athena.ohdsi.org/search-terms/terms/32901 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status primary admission diagnosis status OMOP4976971 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status confirmed diagnosis status OMOP4976963 Principal diagnosis describes the underlying cause behind a patient’s initial hospital admission and is assigned only after a physician has completed necessary tests and examinations. Oliver He, Long Tran https://www.definitivehc.com/resources/glossary/principal-diagnosis principal diagnosis A discharge diagnosis is a final diagnosis given a patient before release from the hospital after all testing, surgery, and workup are complete. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://medical-dictionary.thefreedictionary.com/discharge+diagnosis discharge diagnosis status OMOP4976966 A postoperative diagnosis is a diagnosis or diagnoses discovered or confirmed during the surgery. Often it is the same as the preoperative diagnosis. Oliver He, Long Tran primary admission diagnosis https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85779000#:~:text=Definition%3A,same%20as%20the%20Preoperative%20Diagnosis. postoperative diagnosis status OMOP4976968 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status preliminary diagnosis status OMOP4976969 A preoperative diagnosis is a surgical diagnosis or diagnoses that are assigned to the patient before the surgical procedure, and is the reason for the surgery. A preoperative diagnosis is, in the opinion of the surgeon, the diagnosis that will be confirmed during surgery. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85778000#:~:text=Definition%3A,will%20be%20confirmed%20during%20surgery. preoperative diagnosis status OMOP4976970 An admitting diagnosis is defined as the initial working diagnosis documented by the patient's admitting or attending physician who determined that inpatient care was necessary. Oliver He, Long Tran admission diagnosis https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://manual.jointcommission.org/releases/TJC2016B/DataElem0540.html#:~:text=Definition%3A&text=The%20admitting%20diagnosis%20is%20defined,that%20inpatient%20care%20was%20necessary. admission diagnosis status OMOP4976960 A cause of death is an official determination of conditions resulting in a human's death, which may be recorded on a death certificate. A cause of death is determined by a medical examiner. Oliver He, Long Tran cause of death https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://en.wikipedia.org/wiki/Cause_of_death https://www.cdc.gov/nchs/data/misc/hb_cod.pdf cause of death status OMOP4976961 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status primary referral diagnosis status OMOP4976974 A referral is a written request from one health professional to another health professional or health service, asking them to diagnose or treat you for a particular condition. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://www.healthdirect.gov.au/what-is-a-referral#:~:text=A%20referral%20is%20a%20written,you%20for%20a%20particular%20condition. referral diagnosis status OMOP4976975 A secondary diagnosis is a condition that coexists at the time of admission, that develops subsequently, or that affects the treatment received and/or length of stay. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://medcom.uiowa.edu/theloop/announcements/understanding-principal-and-secondary-conditions-2 secondary diagnosis status OMOP4976978 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status secondary discharge diagnosis status OMOP4976979 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status secondary referral diagnosis status OMOP4976980 The status of have the primary admission diagnosis Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms/32901 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status preliminary admission diagnosis status OMOP4976971 The status of have the primary admission diagnosis Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms/32901 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status preliminary discharge diagnosis status OMOP4976971 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status condition to be diagnosed by procedure status OMOP4976962 A contributory cause of death is a significant condition that unfavourably influences the course of the morbid process and thus contributes to the fatal outcome, but which is not related to the disease or condition directly causing death. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://stats.oecd.org/glossary/detail.asp?ID=444 contributory cause of death status OMOP4976964 An immediate cause of death is a final disease, injury, or complication directly causing the death Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://www.cdc.gov/nchs/data/misc/hb_cod.pdf immediate cause of death status OMOP4976967 A process of a person’s exposure to a foreign physical object or instrument which is used for diagnostic or therapeutic purposes through a mechanism beyond chemical action. Devices include implantable objects (e.g. pacemakers, stents, artificial joints), medical equipment and supplies (e.g. bandages, crutches, syringes), other instruments used in medical procedures (e.g. sutures, defibrillators) and material used in clinical care (e.g. adhesives, body material, dental material, surgical material). Oliver He, Long Tran device exposure https://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE medical device exposure http://purl.obolibrary.org/obo/NCIT_C102617 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status primary discharge diagnosis status OMOP4976973 the date or time on which a device exposure occurs Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE device exposure temporal region The date on which a device exposure ends. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE "Put the end date or discontinuation date as it appears from the source data or leave blank if unavailable." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE device exposure end date The date and time on which a device exposure ends. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE "If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE device exposure end datetime Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status secondary admission diagnosis status OMOP4976977 A medical condition status in which the subject is not presently experiencing the condition or situation and there is a negligible perceived risk of the condition or situation returning. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms/32906 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://build.fhir.org/ig/HL7/UTG/CodeSystem-condition-clinical.html resolved condition status OMOP4976976 The underlying cause of death refers to the disease or injury that initiated the train of morbid events leading directly to death or the circumstances of the accident or violence that produced the injury. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://stats.oecd.org/glossary/detail.asp?ID=2790 https://www.cdc.gov/nchs/data/misc/hb_cod.pdf underlying cause of death status OMOP4976981 The date on which a device exposure starts. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE "Valid entries include a start date of a procedure to implant a device, the date of a prescription for a device, or the date of device administration." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE device exposure start date The date and time on which a device exposure starts. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE "This is not required, though it is in v6. If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE device exposure start datetime the date or time on which a drug exposure occurs in a patient Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug exposure temporal region The date on which a drug exposure starts. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE "Valid entries include a start date of a prescription, the date a prescription was filled, or the date on which a Drug administration was recorded. It is a valid ETL choice to use the date the drug was ordered as the DRUG_EXPOSURE_START_DATE." http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug exposure start date The date and time on which a drug exposure starts. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE "This is not required, though it is in v6. If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)." http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug exposure start datetime The date on which a drug exposure ends for a patient. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug exposure end date The date and time on which a drug exposure ends for a patient. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE "This is not required, though it is in v6. If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)". http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug exposure end datetime The reason a person stopped a medication as it is represented in the source. Reasons include regimen completed, changed, removed, etc. Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE This information is often not populated in source data and it is a valid etl choice to leave it blank if the information does not exist. This field will be retired in v6.0 of the OMOP CDM, . http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug exposure stop reason specification An action specification that represents the intended refills at time of the prescription. Oliver He, Long Tran drug refills specification from prescription http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE This is only filled in when the record is coming from a prescription. http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug refills specification The end date of a drug exposure as it appears in the source data Oliver He, Long Tran http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug exposure verbatim end date An exposure or contact of a person to a drug. The drug exposure includes drug dispensing or administration for a person. http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE This term is used in OMOP CDM. This term appears similar to 'drug administration'. However, drug exposure also covers involuntary, but drug administration usually means voluntary. More discussion is needed. http://purl.obolibrary.org/obo/NCIT_C41362 drug exposure In drug exposure, the quantity refers to number of pieces, e.g. tablets. In the example: 20 Ingredient dose= quantity x amount_value [amount_unit_concept_id] Acetaminophen dose = 20 x 500mg = 10,000mg Daily dose = Acetaminophen dose/drug duration The quantity of drug exposure refers to the number of drug pieces, e.g. tablets, that are exposed to a person. Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE https://ohdsi.github.io/CommonDataModel/drug_dose.html quantity of drug exposure This days of the supply of a drug that is given on the prescription. Long Tran, Oliver He days supply of drug http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE days of drug supply A period time when an observation is conducted. Oliver He, Long Tran participant observation duration time https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD In OMOP, the observation table contains records that defines spans of time during which two conditions are expected to hold: (i) Clinical Events that happened to the Person are recorded in the Event tables, and (ii) absense of records indicate such Events did not occur during this span of time. observation period EUPATH_0000138 A temporal region that is associated with an observation Long Tran, Oliver He https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD observation temporal region A date when an observation starts. Long Tran, Oliver He https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD observation period start date A date when an observation ends. Long Tran, Oliver He https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD observation period end date A time when a measurement is conducted. Long Tran, Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT measurement time A date when a measurement is conducted. Long Tran, Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT measurement date A datetime when a measurement is conducted. Long Tran, Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT measurement datetime A unique key given to a Measurement record for a Person. Such record can be used in the ETL for how duplicate Measurements during the same Visit were handled. Oliver He, Long Tran measurement ID http://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT clnical measurement identifier Payer plan is a plan specification that captures the details of the period of time that a person is continuously enrolled under a specific health Plan benefit structure from a given payer. Each person receiving healthcare is typically covered by a health benefit plan, which pays for (fully or partially), or directly provides, the care. These benefit plans are provided by payers, such as health insurances or state or government agencies. Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD payer plan A temporal region that is associated with the payment process defined in a payer plan Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD payer plan temporal region A period time of the payment that is covered by a payer plan for a person. Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD payer plan period A date when a payer plan period starts. Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD payer plan period start date A date when a payer plan period ends. Long Tran, Oliver He http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD payer plan period end date A process that a patient experiences over a period of time. Oliver He, Long Tran https://ohdsi.github.io/CommonDataModel/cdm54.html medical occurrence An electronic health record that records the information of medical condition. Long Tran, Oliver He Condition Occurrence Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE condition occurrence record An electronic health record that records the information of medical cost. Long Tran, Oliver He Cost Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#COST electronic health cost record As part of the OMOP CDM, use the type concept that be reflects the source of the death record. It is possible that an administrative claims database would source death information from a government file so do not assume the Death Type is the same as the Visit Type, etc. An electronic health record that records the information of the death record of a person. Long Tran, Oliver He Death Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#DEATH electronic death record An electronic health record that records the information of medical device usage. Long Tran, Oliver He Device Exposure Type Concept Device Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE electronic device record As part of the OMOP CDM, choose the drug_type_concept_id that best represents the provenance of the record, for example whether it came from a record of a prescription written or physician administered drug. An electronic health record that records the information of drug usage including drug prescriptions written, prescriptions dispensed, medication history, patient-reported exposure, etc. Long Tran, Oliver He Drug Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE electronic drug record A data item that captures clinical facts about a patient obtained in the context of examination, questioning or a procedure. Long Tran, Oliver He medical observation observation http://ohdsi.github.io/CommonDataModel/cdm54.html#OBSERVATION This term is dervied from OMOP:Observation term. Observations differ from Measurements in that they do not require a standardized test or some other activity to generate clinical fact. Typical observations are medical history, family history, the stated need for certain treatment, social circumstances, lifestyle choices, healthcare utilization patterns, etc. medical observation data An electronic health record that records the information of medical Episode record. Long Tran, Oliver He Procedure Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#EPISODE electronic episode record An electronic health record that records the information of medical measurement record. Long Tran, Oliver He Measurement Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT electronic measurement record As part of the OMOP CDM, the provenance of the notes most likely will be EHR. An electronic health record that records the information of medical notes. Long Tran, Oliver He Note Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#NOTE electronic health note record An electronic health record that records the information of medical observational record. Long Tran, Oliver He Observation Period Type Concept Observation Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#OBSERVATION electronic health observation record As part of the OMOP CDM, PROCEDURE TYPE CONCEPT best represents the provenance of the record, for example whether it came from an EHR record or billing claim. If a procedure is recorded as an EHR encounter, the PROCEDURE_TYPE_CONCEPT would be ‘EHR encounter record’. An electronic health record that records the information of Procedure record. Long Tran, Oliver He Procedure Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE electronic health procedure record An electronic health record that records the information of the specimen record. Long Tran, Oliver He Specimen Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#SPECIMEN electronic specimen record As part of the OMOP CDM, populate this field based on the provenance of the visit record, as in whether it came from an EHR record or billing claim. An electronic health record that records the information of medical visit. Long Tran, Oliver He Visit Type Concept https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE electronic medical visit record Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status preliminary diagnosis OMOP4976969 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms/32901 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status preliminary admission diagnosis OMOP4976971 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms/32901 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status preliminary discharge diagnosis OMOP4976971 The primary diagnosis is a diagnosis of the patient condition that demands the most provider resources during the patient’s stay. Oliver He, Long Tran primary diagnosis https://athena.ohdsi.org/search-terms/terms/32902 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://www.definitivehc.com/resources/glossary/primary-diagnosis There is often confusion surrounding primary and principal diagnoses and, consequently, the terms are commonly used interchangeably. While these can be (and frequently are) the same diagnosis in practice, their definitions are distinct. While a principal diagnosis is the underlying cause of patient symptoms, the primary diagnosis is used for healthcare billing purposes. Reference: https://www.definitivehc.com/resources/glossary/primary-diagnosis primary diagnosis OMOP4976972 Oliver He, Long Tran primary admission diagnosis https://athena.ohdsi.org/search-terms/terms/32901 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status primary admission diagnosis OMOP4976971 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status primary discharge diagnosis OMOP4976973 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status primary referral diagnosis OMOP4976974 A secondary diagnosis is a diagnosis made at the time of admission, that develops subsequently, or that affects the treatment received and/or length of stay. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://medcom.uiowa.edu/theloop/announcements/understanding-principal-and-secondary-conditions-2 secondary diagnosis OMOP4976978 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status secondary admission diagnosis OMOP4976977 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status secondary discharge diagnosis OMOP4976979 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status secondary referral diagnosis OMOP4976980 An admitting diagnosis is defined as the initial working diagnosis documented by the patient's admitting. Oliver He, Long Tran admission diagnosis https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://manual.jointcommission.org/releases/TJC2016B/DataElem0540.html#:~:text=Definition%3A&text=The%20admitting%20diagnosis%20is%20defined,that%20inpatient%20care%20was%20necessary. admission diagnosis OMOP4976960 Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status confirmed diagnosis OMOP4976963 The diagnosis of the death of a person Oliver He, Long Tran death diagnosis https://athena.ohdsi.org/search-terms/terms/32895 https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status death diagnosis OMOP4976965 A discharge diagnosis is a final diagnosis given a patient before release from the hospital after all testing, surgery, and workup are complete. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://medical-dictionary.thefreedictionary.com/discharge+diagnosis discharge diagnosis OMOP4976966 A postoperative diagnosis is a diagnosis or diagnoses discovered or confirmed during the surgery. Often it is the same as the preoperative diagnosis. Oliver He, Long Tran primary admission diagnosis https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85779000#:~:text=Definition%3A,same%20as%20the%20Preoperative%20Diagnosis. postoperative diagnosis OMOP4976968 A medical occurrence in which a patience is exposed to a medical related material entity such as drug or medical device. Medical exposure refers primarily to exposure incurred by patients for the purpose of medical diagnosis or treatment. Oliver He, Long Tran https://www.sciencedirect.com/topics/engineering/medical-exposure medical exposure A preoperative diagnosis is a surgical diagnosis or diagnoses that are assigned to the patient before the surgical procedure, and is the reason for the surgery. A preoperative diagnosis is, in the opinion of the surgeon, the diagnosis that will be confirmed during surgery. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85778000#:~:text=Definition%3A,will%20be%20confirmed%20during%20surgery. preoperative diagnosis OMOP4976970 A referral is a written request from one health professional to another health professional or health service, asking them to diagnose or treat you for a particular condition. Oliver He, Long Tran https://athena.ohdsi.org/search-terms/terms?domain=Condition+Status https://www.healthdirect.gov.au/what-is-a-referral#:~:text=A%20referral%20is%20a%20written,you%20for%20a%20particular%20condition. referral diagnosis OMOP4976975 An acellular self-replicating organic structure that is composed of nucleic acid Oliver He https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures self-replicating nucleic acid A self-replicating nucleic acid that can move around within a genome, or that can be transferred from one species or replicon to another. Oliver He https://en.wikipedia.org/wiki/Mobile_genetic_elements https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures mobile genetic element A mobile genetic element that is composed of a generally circular extrachromosomal DNA molecule and is able to replicate and be transmitted independent of chromosomal DNA. Oliver He https://en.wikipedia.org/wiki/Mobile_genetic_elements https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures plasmid A mobile genetic element that is composed of a DNA sequence and can move and replicate in different parts of a cell's genome. Oliver He https://en.wikipedia.org/wiki/Mobile_genetic_elements https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures transposon A centrally registered identifier that is a unique identifier for an episode in precision medicine. As defined in OMOP CDM, the EPISODE table aggregates lower-level clinical events (e.g., VISIT_OCCURRENCE) into a higher-level abstraction representing clinically and analytically relevant disease phases, outcomes and treatments. The EPISODE_EVENT table connects qualifying clinical events to the appropriate EPISODE entry. Oliver He, Minh-Y Nguyen episode_id https://ohdsi.github.io/CommonDataModel/cdm54.html#episode episode ID A medical episode is a medical event that aggregates lower-level clinical events (e.g., visit occurrence, drug exposure, procedure occurrence, device occurrence) into a higher-level abstraction representing clinically and analytically relevant disease phases, outcomes, and treatments. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode medical episode A medical episode event connects qualifying specific clinical events (such as condition or procedure occurrence, or measurement) to the appropriate episode entry. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode_event medical episode event The date when a medical episode begins. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode episode start date The date when a medical episode ends. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode episode end date The date and time when a medical episode begins. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode episode start datetime The date and time when a medical episode ends. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode episode end datetime A medical episode that includes events related to a patient disease. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode disease episode A medical episode that includes events related to a patient treatment. Minh-Y Nguyen Oliver He https://ohdsi.github.io/CommonDataModel/cdm54.html#episode treatment episode A centrally registered identifier that refers to a value defined by the original data source, such as a patient's value assigned by the original hospital. Oliver He Yujia Tian http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON source value A person source value that refers to a person identifier assigned by the original data source, such as a hospital where the person sees doctors. Oliver He Yujia Tian person_source_value http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON person source value A gender source value refers to the biological sex of the person from original data source. Only use for reference. Yujia Tian gender_source_value http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON gender source value A race source value that refers to the race of the person from the original data source. For reference only. Yujia Tian race_source_value http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON race source value A ethnicity source value that refers to the ethnicity of the person from the original data source. Yujia Tian ethnicity_source_value http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON ethnicity source value A visit source value that refers to the original term used to describe the visit type (e.g., inpatient, outpatient, emergency) in the source data. For reference only. Yujia Tian visit_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#visit_occurrence visit source value A discharge destination source value that refers to the verbatim value from the original data source describing where the patient was discharged to. Yujia Tian discharged_to_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#visit_occurrence discharged to source value A visit detail source value that refers to the original description of the visit type (e.g., inpatient, outpatient, emergency) from the source data. For reference only. Yujia Tian visit_detail_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#visit_detail visit detail source value An admission source value that refers to where the patient was admitted from, as recorded in the original data source (e.g., home, another hospital, emergency room). Yujia Tian admitted_from_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#visit_detail admitted from source value A condition source value that refers to the condition as recorded in the original data source (e.g., ICD-10 or Read code). Yujia Tian condition_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#condition_occurrence condition source value A concept that corresponds to the condition source value, which may not be standard. Not recommended for analysis, as it is not required to use Standard Concepts. Use only when no suitable Standard Concept exists to capture the necessary source detail. Prefer using condition_concept_id for consistent, standardized analytics across the network. Yujia Tian condition_status_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#condition_occurrence condition status source value A drug exposure source value that refers to the medication as recorded in the original data source (e.g., NDC or Gemscript code). Yujia Tian drug_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#drug_exposure drug source value A drug route source value that refers to the route of administration as recorded in the original data source (e.g., oral, intravenous). For reference only. Yujia Tian route_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#drug_exposure route source value A dose unit source value that refers to the verbatim value from the source data representing the dose unit of the drug given. Yujia Tian dose_unit_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#drug_exposure dose unit source value A procedure source value that refers to the procedure recorded in the original data source (e.g., CPT4 or OPCS4 code). For reference only. Yujia Tian procedure_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#procedure_occurrence procedure source value A procedure modifier source value that refers to the modifier code recorded in the original data source. For reference only. Yujia Tian modifier_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#procedure_occurrence modifier source value A device source value that refers to the device recorded in the original data source (e.g., NDC or Gemscript code). Yujia Tian device_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#device_exposure device source value A unit source value that refers to the unit recorded in the original data source (e.g., mL for blood transfusions). For reference only. Yujia Tian unit_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#device_exposure unit source value A measurement source value that refers to the measurement recorded in the original data source. For reference only. Yujia Tian measurement_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#measurement measurement source value A value source value that refers the verbatim result value of the Measurement from the source data. For reference only. Yujia Tian value_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#measurement value source value An observation source value that refers to the observation recorded in the original data source. Yujia Tian observation_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#observation observation source value An qualifier source value that refers to the verbatim value from the source data representing the qualifier of the Observation that occurred. For reference only. Yujia Tian qualifier_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#observation qualifier source value A cause source value that refers to the person's death cause reason in original data source. Yujia Tian cause_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#death cause source value A note source value that refers to the note stored in original source value. For reference only. Yujia Tian note_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#note note source value A specimen source value that refers to the specimen type or description recorded in the original data source. For reference only. Yujia Tian specimen_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#specimen specimen source value An anatomic site source value that refers to the body location recorded in the original data source. Yujia Tian anatomic_site_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#specimen anatomic site source value A disease status source value that refers to the condition status (e.g., active, remission) recorded in the original data source. Yujia Tian disease_status_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#specimen disease status source value A location source value that refers to the place or address information recorded in the original data source. For reference only. Yujia Tian location_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#location location source value A country source value that refers to the name of the country in the original data source. Yujia Tian country_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#location country source value A care site source identifier as recorded in the original data source. May differ from the care site name. Yujia Tian care_site_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#care_site care site source value A place of service source value that refers to the setting of care (e.g., outpatient clinic, inpatient hospital) recorded in the original data source. For reference only. Yujia Tian place_of_service_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#care_site place of service source value A provider source value used to link back to the provider in the original data source, typically for ETL validation or error checking. For reference only. Yujia Tian provider_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#provider provider source value A provider specialty source value that refers to the type of healthcare provider or field of expertise recorded in the original data source (e.g., internal medicine, emergency medicine, nursing, physical therapy). For reference only. Yujia Tian specialty_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#provider specialty source value A payer source value that refers to this is the Payer as it appears in the source data. For reference only. Yujia Tian payer_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period payer source value A plan source value that refers to the insurance or coverage type recorded in the original data source. For reference only. Yujia Tian plan_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period plan source value A plan sponsor source value that refers to the sponsor or organization responsible for the health plan, as recorded in the original data source. For reference only. Yujia Tian sponsor_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period sponsor source value A family source value that refers to the common identifier for all individuals covered under the same policy, as recorded in the original data source. For reference only. Yujia Tian family_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period family source value A stop reason source value that refers to the reason the person left the plan, as recorded in the original data source (if available). For reference only. Yujia Tian stop_reason_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period stop reason source value A revenue code source value that refers to the billing classification for procedures or conditions, as recorded in the original data source (used in the U.S. hospital system). For reference only. Yujia Tian revenue_code_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#cost revenue code source value A diagnosis-related group (DRG) source value that refers to the classification code for hospital cases (used in the U.S.), as recorded in the original data source. Yujia Tian drg_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#cost drg source value An episode source value that refers to the original code for the episode recorded in the source data. This code is mapped to a standard condition concept, and the original value is stored here. Yujia Tian episode_source_value https://ohdsi.github.io/CommonDataModel/cdm54.html#episode episode source value A medical vist that occurs within the scope of a parent medical visit. Each subvisit represents a meaningful subdivision of the overall visit, such as a change in care setting, a specific unit stay, or an individual service episode (e.g., a claim line), and is linked to a single parent visit. Oliver He, Yujia Tian detail visit nested visit subvisit visit episode https://en.wikipedia.org/wiki/Inpatient_care medical subvisit It is based on drug exposure table to combined all exposures close enough into a single drug era. Yujia Tian http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE drug era condition_era groups multiple, closely timed occurrences of the same diagnosis into one interval, making analysis of prevalence, duration, and chronicity much easier and more accurate Yujia Tian condition_era medical condition era A textual entity represents the free text note prvide from provider about a patient notes in given date Yujia Tian clinical note clinical note Vocabulary have few related definitions, in linguistics or data science a vocabulary can mean a set of recognized terms or tokens Yujia Tian vocabulary Terminology refers to a set of specialized words or expressions used in a specific field, subject, or profession Yujia Tian terminology Ontology is a formal representation of knowledge as a set of concepts (classes), relationships, and terms within a domain, often with defined meanings and logical structure. Yujia Tian ontology A centrally registered identifier that refers to a value defined by the original data source, such as a patient's value assigned by the original hospital. Oliver He Yujia Tian http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON concept ID Transfer the value from different source value into a standard concept. Yujia Tian https://ohdsi.github.io/CommonDataModel/cdm54.html#source_to_concept_map source concept identifier Stores the concept_id corresponding to the concept of "sex at birth" in the source system. Yujia Tian gender_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#person gender source concept identifier Stores the concept_id corresponding to the concept of race in the source system. Yujia Tian race_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#person race source concept identifier Stores the concept_id corresponding to the concept of "ethnicity" in the source system. Yujia Tian ethnicity_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#person ethnicity source concept identifier The visit source concept represents the concept_id from the source system that was used to encode the type of visit—this is only populated if the source stores visit types as concept IDs; otherwise it is set to 0. Yujia Tian visit_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#visit_occurrence visit source concept identifier visit_source_concept_id stores the identifier of the concept originally used by the source system to represent the visit type—only included if the source itself recorded visits using concept IDs; otherwise, it’s set to 0. Yujia Tian visit_detail_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#visit_occurrence visit detail source concept identifier The concept identifier representing the original condition code from the source data, which may be non-standard and primarily used when greater source detail is needed. Yujia Tian condition_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#condition_occurrence condition source concept identifier A concept identifier representing the original drug code from the source data, used when standard concepts do not capture sufficient detail. Yujia Tian drug_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#drug_exposure drug source concept identifier A concept identifier representing the original procedure code from the source data, used when standard concepts do not fully capture the procedure details. Yujia Tian procedure_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#procedure_occurrence procedure source concept identifier A concept identifier that captures the original device code from the source data when standard device concepts do not provide sufficient detail. Yujia Tian device_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#device_exposure device source concept identifier A concept identifier that captures the original unit of measurement from the source data when standard unit concepts are insufficient. Yujia Tian unit_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#device_exposure unit source concept identifier A concept identifier used to capture the original source-specific measurement type when standard concepts are insufficient to represent it. Yujia Tian measurement_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#measurement measurement source concept identifier A concept identifier used to capture the original source-specific observation when standardized concepts are not sufficient to represent its detail. Yujia Tian observation_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#observation observation source concept identifier A concept identifier used to record the original cause of death as coded in the source system, even if it is not standardized. Yujia Tian cause_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#death cause source concept identifier A concept identifier that represents the original source code for clinical terms extracted from notes using natural language processing. Yujia Tian note_nlp_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#note_nlp note nlp source concept identifier A concept identifier that represents the source code for provider specialty, if recorded using a supported vocabulary; often zero when proprietary codes are used. Yujia Tian specialty_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#provider specialty source concept identifier A concept identifier that represents the source code for the payer (e.g., insurance provider) from the original data, when available in a supported vocabulary. Yujia Tian payer_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period payer source concept identifier A concept identifier representing the source code for the insurance plan in the original data, when the plan is coded using a vocabulary supported by the data network. Yujia Tian plan_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period plan source concept identifier A concept identifier representing the source code for the sponsor of the insurance plan, if the source data uses a supported vocabulary. Yujia Tian sponser_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period sponsor source concept identifier A concept identifier representing the coded reason for stopping a treatment or drug, based on the original source vocabulary. Yujia Tian stop_reason_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#payer_plan_period stop reason source concept identifier The source code for the Episode as it appears in the original source data. This code is mapped to a Standard Condition Concept in the Standardized Vocabularies, and the original code is stored here for reference. Yujia Tian episode_source_concept_id https://ohdsi.github.io/CommonDataModel/cdm54.html#episode episode source concept identifier The date and time of death of a person. Yujia Tian https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:person https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:single-page This term is generated to be equivalent to the "death_date" in OMOP. Also note: in OMOP v6.0, DATETIME fields were made mandatory and date fields were made optional. Reference: https://ohdsi.github.io/CommonDataModel/cdm60.html#PERSON date of death time that is related to the death Yujia Tian time of death death-related time The date and time of death of a person. Yujia Tian https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:person https://www.ohdsi.org/web/wiki/doku.php?id=documentation:cdm:single-page This term is generated to be equivalent to the "death_datetime" in OMOP. Also note: in OMOP v6.0, DATETIME fields were made mandatory and date fields were made optional. Reference: https://ohdsi.github.io/CommonDataModel/cdm60.html#PERSON death datetime Geographic coordinates are a system of using latitude and longitude to pinpoint exact locations on Earth. Yujia Tian geographic coordinate Latitude is a geographic coordinate that specifies the north-south position of a point on the Earth's surface. It's measured as an angle, ranging from 0° at the Equator to 90° at the North and South Poles. Yujia Tian latitude Longitude is a geographic coordinate that specifies the east-west position of a point on Earth's surface. It's measured in degrees, with the Prime Meridian (passing through Greenwich, England) being 0°. Yujia Tian longitude 17 A age quality that is measured by the value of less than 18 years old Fred Dowd, Oliver He age less than 18 years old age less than 18 years GFR 30-59 mL/min/1.73m2 eGFR >=60 mL/min/1.73m2 with urine albumin excretion >= 30 mg/g creatinine eGFR >= 60 mL/min/1.73m2 with urine protein excretion >= 150 mg/g creatinine A role of a person (e.g., a study participant, participant's family member, or participant's physician) who provides the medical history information. Edison Ong, Oliver He medical history information provider role A role of a person who is a family member of a participant in an investigation study. Edison Ong, Oliver He study participant's family member role a role of a physician who takes care of a study participant Edison Ong, Oliver He study participant's physician role An age when a disease is first diagnosed age at diagnosis of disease age at diagnosis of kidney disease Whether chronic kidney disease Whether acute kidney injury time of biopsy year of kidney biopsy time of kidney biopsy month of kidney biopsy age at the start of kidney stone An age when a disease started in a patient age at the start of disease Whether diabetes age at diagosis of diabetes What disease What type of diabetes treatment question medicatoin treatment question surgical treatment question Whether taking medication for diabetes An age when a medication is first used age at the start of medication age at the start of taking medication for diabetes What medication What medication taken for diabetes Whether insulin taken for diabetes Whether diabetes during pregnancy a clinical trial is a medical interventional study where participants are assigned prospectively to an intervention or interventions according to a protocol to evaluate the safety and efficacy of the intervention(s) on biomedical or other health related outcomes. The Interventions include but are not restricted to drugs, cells and other biological products, surgical procedures, radiologic procedures, devices, behavioral treatments, process-of-care changes, preventive care, etc. Oliver He, Asiyah Yu Lin, Qingliang Li interventional trial https://clinicaltrials.gov/ct2/search/map https://en.wikipedia.org/wiki/Clinical_trial https://prsinfo.clinicaltrials.gov/definitions.html https://www.who.int/ictrp/en/ clinical trial A clinical trial that is at an Early Phase i or Phase 0, which is designed to use an investigational agent that is available only in very limited quantities and which has never previously given to humans or for which there is extremely limited human experience. Phase 0 clinical trials are intended to enable researchers to understand the path of the drug in the body and its efficacy. Adverse event reporting in Phase 0 trials is expedited. [def-source: NCI] Leon Li, Asiyah Lin, Oliver He Phase 0 clinical trial Phase 0 trial Pre-Clinical Trial http://purl.obolibrary.org/obo/NCIT_C54721 https://en.wikipedia.org/wiki/Clinical_trial Early Phase 1 clinical trial A clinical trial that is at Phase 1, which is often the first-in-man trial, and it tests within a small group of people (typically 20-80) to evaluate safety, determine safe dosage ranges, and begin to identify side effects. A drug's side effects could be subtle or long term, or may only happen with a few people, so phase 1 trials are not expected to identify all side effects. Leon Li, Asiyah Lin, Oliver He Phase 1 trial Phase I clinical trial clinical trial for safety screening http://purl.obolibrary.org/obo/NCIT_C15600 https://en.wikipedia.org/wiki/Clinical_trial C0920321 C15600 Phase 1 clinical trial A clinical trial that is at Phase 2, which is designed to study a biomedical or behavioral intervention in a larger group of people (several hundred), to evaluate the drug's effectiveness for a particular indication in patients with the disease or condition under study, and to determine the common short-term side effects and risks associated with the intervention. [def-source: NCI] Leon Li, Asiyah Lin, Oliver He Phase 2 trial Phase II clinical trial Phase II trial http://purl.obolibrary.org/obo/NCIT_C15601 https://en.wikipedia.org/wiki/Clinical_trial C0282460 C15601 Phase 2 clinical trial A clinical trial that is at Phase 3, which is designed to investigate the efficacy of the biomedical or behavioral intervention in large groups of human subjects (from several hundred to several thousand), to confirm efficacy, to monitor adverse reactions to the new medication or treatment regimen with respect to long-term use and by comparing the intervention to other standard or experimental interventions as well as to a placebo. [def-source: NCI] Leon Li, Asiyah Lin, Oliver He Phase III trial https://en.wikipedia.org/wiki/Clinical_trial C0282461 C15602 Phase 3 clinical trial A clinical trial that is at Phase 4 Leon Li, Asiyah Lin, Oliver He https://en.wikipedia.org/wiki/Clinical_trial C0282462 C15603 Phase 4 clinical trial A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities quality (PATO) trait quality A time quality inhering in a bearer by virtue of how long the bearer has existed. quality PATO:0000011 age An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved. 患者生理性别在特定编码体系中的代码 Suyuan Peng, Hong Yu, Yongqun He 《电子病历基本数据集 第10部分：住院病案首页》WS 445.10-2014 quality PATO:0000047 biological sex A 1-D extent quality inhering in a bearer by virtue of the bearer's vertical dimension of extension. quality PATO:0000119 height A physical quality inhering in a bearer that has mass near a gravitational body. quality PATO:0000128 weight A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity. location placement relational spatial quality position An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation. PATO:0001722 behavioural quality quality PATO:0000186 behavioral quality A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes. quality PATO:0000383 female A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes. quality PATO:0000384 male A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. PATO:0002079 Wikipedia:Physical_property relational physical quality quality PATO:0001018 physical quality A quality which inheres in an process. PATO:0001239 PATO:0001240 quality of a process quality of occurrent quality of process relational quality of occurrent quality PATO:0001236 See comments of relational quality of a physical entity. process quality A quality which inheres in a continuant. PATO:0001237 PATO:0001238 snap:Quality monadic quality of a continuant multiply inhering quality of a physical entity multiply inhering quality of a physical entity quality of a continuant quality of a single physical entity quality of an object quality of continuant monadic quality of an object monadic quality of continuant quality PATO:0001241 Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. physical object quality An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics. quality PATO:0001894 phenotypic sex A quality that inheres in an entire organism or part of an organism. quality PATO:0001995 organismal quality A positional quality inhering in a bearer by virtue the bearer's being changed in position. displaced A material entity that consists of two or more organisms, viruses, or viroids. A material entity that consists of two or more organisms, viruses, or viroids. collection of organisms collection of organisms A community of at least two different species, living in a particular area. Must have at least two populations of different species as members. envoPolar ecological community A collection of organisms of the same species whose members are all either genealogically related to each other or have mated with each other. community A collection of organisms that consists of two or more organisms from at least two species. multi-species collection of organisms A material entity that is one or more organisms, viruses or viroids. organismal entity An anatomical entity that is or was part of a plant. entidad anat&#243mica vegetal (Spanish, exact) 植物 解剖学（形態）的実体 (Japanese, exact) plant anatomical entity protein antithrombin III is a protein An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. protein A material entity consisting of multiple components that are causally integrated. May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43 Chris Mungall http://www.jbiomedsem.com/content/4/1/43 system region A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids. primary structure of sequence macromolecule sequence region Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG] we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive EHDAA2:0001844 EHDAA:6530 EMAPA:17525 EV:0100152 FMA:86166 GAID:933 MA:0000151 MAT:0000284 MESH:D012867 MIAA:0000284 OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA VHOG:0000860 portion of skin region of skin skin skin region skin zone uberon UBERON:0000014 zone of skin A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. AEO:0000192 CARO:0000010 FMA:50705 uberon UBERON:0000015 Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. anatomical boundary Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts) tubular galen:Tube anatomical tube duct uberon UBERON:0000025 tube Major subdivision of an organism that protrudes from the body[DOS, CARO]. An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018]. Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]. appendicular this is currently a subtype of organism subdivision - which would exclude feathers AEO:0000193 BILA:0000018 BTO:0001492 CARO:0010003 EFO:0000799 EHDAA2:0003193 EV:0100155 FBbt:00007000 HAO:0000144 MAT:0000023 MESH:D005121 MIAA:0000023 OpenCyc:Mx4rvViC-JwpEbGdrcN5Y29ycA UMLS:C0598782 VSAO:0000075 XAO:0000218 uberon appendages extremitaet extremity limbs/digits/tail UBERON:0000026 appendage The head is the anterior-most division of the body [GO]. Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO] Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO] Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG] AAO:0010335 AEO:0000106 BILA:0000115 BTO:0000282 CALOHA:TS-0436 EFO:0000964 EHDAA2:0003106 EMAPA:31858 FBbt:00000004 FMA:7154 GAID:61 HAO:0000397 MA:0000023 MAT:0000294 MESH:D006257 MIAA:0000294 OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA SPD:0000016 TAO:0001114 TGMA:0000002 UMLS:C0018670 VHOG:0001644 WBbt:0005739 XAO:0003024 ZFA:0001114 galen:Head head (volume) adult head uberon cephalic area UBERON:0000033 head multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO] a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP] in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA. FMA:9581 GAID:19 MESH:D012704 TAO:0005425 UMLS:C0036760 ZFA:0005425 tunica serosa wall of serous sac uberon serosa UBERON:0000042 serous membrane A tubular structure that contains, conveys body fluid, such as blood or lymph. uberon UBERON:0000055 vessel A tubular structure that transports secreted or excreted substances. A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]. Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here. AAO:0011123 FBbt:00100314 FMA:30320 TAO:0005171 UMLS:C0687028 XAO:0004000 ZFA:0005171 galen:Duct anatomical duct exocrine duct exocrine gland duct uberon ducts UBERON:0000058 duct Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. in FMA, serosa is a wall UBERON:0009915 wall EMAPA:25036 FMA:82482 galen:Wall wall of organ uberon organ wall UBERON:0000060 anatomical wall Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. AAO:0010825 AEO:0000003 BILA:0000003 CARO:0000003 EHDAA2:0003003 EMAPA:0 FBbt:00007001 FMA:67135 GAID:781 HAO:0000003 MA:0003000 MESH:D000825 TAO:0000037 TGMA:0001823 VHOG:0001759 WBbt:0000100 XAO:0003000 ZFA:0000037 biological structure connected biological structure uberon UBERON:0000061 anatomical structure Anatomical structure that performs a specific function or group of functions [WP]. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4 CARO:0020004 EFO:0000634 EMAPA:35949 ENVO:01000162 FMA:67498 MA:0003001 OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA UMLS:C0178784 WBbt:0003760 uberon anatomical unit body organ element UBERON:0000062 organ A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball. Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal. FMA:86140 uberon organ region with fixed fiat boundary organ segment segment of organ UBERON:0000063 organ subunit A multicellular structure that is a part of an organ. currently defined in a very broad sense, may be replaced by more specific classes in the future AAO:0011124 EFO:0000635 FMA:82472 cardinal organ part uberon regional part of organ UBERON:0000064 organ part The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. adult stage BTO:0001043 BilaDO:0000004 EFO:0001272 FBdv:00005369 WBls:0000041 XtroDO:0000084 fully formed animal stage juvenile-adult stage uberon UBERON:0000066 fully formed stage A stage that is part of the embryo stage. embryonic stage part uberon UBERON:0000067 embryo stage part A life cycle stage that starts with fertilization and ends with the fully formed embryo. BilaDO:0000002 EV:0300001 FBdv:00005289 FMA:72652 HsapDv:0000002 MmusDv:0000002 OGES:000000 OGES:000022 WBls:0000003 WBls:0000092 WBls:0000102 XAO:1000012 embryonic stage uberon embryogenesis UBERON:0000068 embryo stage End of the life of an organism. ncit:Death is an outcome XAO:0000437 XtroDO:0000085 uberon death UBERON:0000071 death stage Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. UBERON:0010322 FMA:85544 UMLS:C1519343 galen:ComplexSkeletalStructure skeletal system subdivision uberon skeletal system part UBERON:0000075 subdivision of skeletal system The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube) (or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis EHDAA2:0001968 EHDAA:1494 EHDAA:350 EHDAA:4784 EHDAA:4790 EHDAA:4796 EHDAA:7860 EMAPA:16096 FMA:87656 UMLS:C1515087 surface (external) ectoderm surface ectoderm uberon UBERON:0000076 external ectoderm stage succeeding embryo, including mature structure In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997) BilaDO:0000003 OGES:000010 OGES:000014 OGES:000024 WBls:0000022 WBls:0000093 WBls:0000103 postembryonic stage post-hatching stage uberon postembryonic UBERON:0000092 post-embryonic stage Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA] cjm 2009-07-30T05:19:13Z membrane FMA:7145 membrane of organ uberon UBERON:0000094 membrane organ An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. FBdv:00000000 HsapDv:0000001 MmusDv:0000001 OGES:000011 ncithesaurus:Life entire life cycle entire lifespan life lifespan uberon UBERON:0000104 life cycle A spatiotemporal region encompassing some part of the life cycle of an organism. this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here the WBls class 'all stages' belongs here as it is the superclass of other WBls stages we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage BILS:0000105 EFO:0000399 FBdv:00007012 FMA:24120 HsapDv:0000000 MmusDv:0000000 OlatDv:0000010 PdumDv:0000090 WBls:0000002 XAO:1000000 ZFS:0000000 ZFS:0100000 ncithesaurus:Developmental_Stage developmental stage stage uberon UBERON:0000105 life cycle stage A stage at which the organism is a single cell produced by means of sexual reproduction. As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG] BILS:0000106 BilaDO:0000005 EFO:0001322 EHDAA:27 EMAPA:16033 FBdv:00005288 PdumDv:0000100 VHOG:0000745 XAO:1000001 ZFS:0000001 1-cell stage fertilized egg stage one cell stage uberon fertilized egg stage one-cell stage zygote zygotum UBERON:0000106 zygote stage The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. BILS:0000107 BilaDO:0000006 EFO:0001290 FBdv:00000054 MESH:A16.254.270 MmusDv:0000004 OGES:000015 OGES:000020 PdumDv:0000200 XAO:1000004 ZFS:0000046 uberon UBERON:0000107 cleavage stage An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. consider adding a preceding stage 'morula stage' as part of cleavage BILS:0000108 BilaDO:0000007 EFO:0001282 HsapDv:0000006 MmusDv:0000007 OGES:000003 OGES:000016 OGES:000021 OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg WBls:0000005 XAO:1000003 ZFS:0000045 uberon UBERON:0000108 blastula stage A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. BILS:0000109 BilaDO:0000008 EFO:0001296 FBdv:00005317 HsapDv:0000010 MmusDv:0000013 OGES:000004 OGES:000019 WBls:0000010 XAO:1000005 ZFS:0000047 uberon blastocystis trilaminaris stage trilaminar blastocyst stage trilaminar blastoderm stage trilaminar disk stage trilaminar germ stage trilaminar stage UBERON:0000109 gastrula stage Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. BILS:0000110 BilaDO:0000009 HsapDv:0000012 MmusDv:0000017 XAO:1000006 uberon UBERON:0000110 neurula stage A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. BILS:0000111 BilaDO:0000010 HsapDv:0000015 MmusDv:0000018 OGES:000005 OGES:000032 uberon segmentation stage UBERON:0000111 organogenesis stage The stage of being a sexually immature adult animal[XAO:1000010]. In mammals this would include infant (nourishment from lactation) and juvenile (prepubertal no longer dependent on mother) BILS:0000112 BTO:0002168 EFO:0001300 EV:0300051 MmusDv:0000043 OGES:000009 XAO:1000010 XtroDO:0000083 ZFS:0000051 immature stage juvenile stage uberon subadult stage UBERON:0000112 sexually immature stage uberon UBERON:0000153 anterior region of body uberon UBERON:0000154 posterior region of body The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO] Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG] oral some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips AAO:0010355 BTO:0001090 BTO:0004698 CALOHA:TS-1315 EFO:0000825 EHDAA2:0001326 EHDAA:542 EMAPA:16262 FBbt:00003126 FMA:49184 GAID:75 MA:0000341 MA:0002474 MAT:0000038 MESH:D009055 MIAA:0000038 OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA TADS:0000040 TAO:0000547 TAO:0000590 TGMA:0000131 VHOG:0000280 VHOG:0000812 XAO:0003029 ZFA:0000547 ZFA:0000590 galen:Mouth regio oralis adult mouth uberon cavital oralis cavitas oris cavum oris mouth cavity oral region oral vestibule rima oris stoma stomatodaeum trophic apparatus vestibule of mouth vestibulum oris UBERON:0000165 mouth A fluid that is composed of blood plasma and erythrocytes. This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO] Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG] AAO:0000046 BTO:0000089 CALOHA:TS-0079 EFO:0000296 EHDAA2:0000176 EHDAA:418 EMAPA:16332 ENVO:02000027 EV:0100047 FMA:9670 GAID:965 MA:0000059 MESH:D001769 MIAA:0000315 OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA TAO:0000007 UMLS:C0005767 VHOG:0000224 XAO:0000124 ZFA:0000007 galen:Blood portion of blood vertebrate blood uberon whole blood UBERON:0000178 blood Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. cjm 2009-04-08T04:38:19Z CARO:0000081 uberon blood or blood analog circulating fluid UBERON:0000179 haemolymphatic fluid Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula UBERON:0007011 BILA:0000059 BTO:0000128 GAID:1294 MESH:A16.254.270.274 OGEM:000006 OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg blastula embryo uberon blastosphere UBERON:0000307 blastula The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77 Anatomical system that consists of the muscles of the body.[VSAO] we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA AAO:0000307 BILA:0000088 BTO:0001369 BTO:0001485 EFO:0000801 EMAPA:35578 FBbt:00005069 FMA:72954 MA:0002888 MAT:0000025 MIAA:0000025 VSAO:0000033 XAO:0004042 muscle system muscle system of body muscular system musculature system set of all muscles set of muscles of body vertebrate muscular system uberon muskelsystem UBERON:0000383 musculature of body A gland in which the principal secretory cells are serous secreting cells. glands that secrete watery albuminous material that often contains enzymes[MP:0008052]. BTO:0001837 FMA:62889 uberon UBERON:0000409 serous gland A portion of organism substance that is produced by exocrine glands. BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions UBERON:0006540 secretion AEO:0001005 BTO:0002977 BTO:0002979 EMAPA:36535 FMA:9675 MA:0002504 MESH:D012634 UMLS:C1516992 galen:Secretion exocrine gland fluid/secretion secreted substance uberon exocrine gland fluid exocrine gland fluid or secretion exocrine gland secretion external secretion UBERON:0000456 bodily secretion organism substance Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. AAO:0010839 AEO:0000004 BILA:0000004 CALOHA:TS-2101 CARO:0000004 EHDAA2:0003004 EMAPA:35178 FBbt:00007019 FMA:9669 HAO:0000004 MA:0002450 SPD:0000008 TAO:0001487 TGMA:0001824 VHOG:0001726 XAO:0004001 ZFA:0001487 galen:BodySubstance body fluid or substance body substance organism substance portion of body substance portion of organism substance uberon UBERON:0000463 organism substance Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. lumen space AAO:0010110 AEO:0000005 BILA:0000005 CARO:0000005 EHDAA2:0003005 FBbt:00007017 FMA:5897 HAO:0000005 TAO:0001668 TGMA:0001825 UMLS:C0524461 VHOG:0001728 XAO:0003190 ZFA:0001643 lumen space uberon anatomical spaces UBERON:0000464 anatomical space material anatomical entity Anatomical entity that has mass. AAO:0010264 AEO:0000006 BILA:0000006 CARO:0000006 EHDAA2:0003006 FBbt:00007016 FMA:67165 HAO:0000006 TAO:0001836 TGMA:0001826 VHOG:0001721 uberon UBERON:0000465 material anatomical entity Anatomical entity that has no mass. AAO:0010265 AEO:0000007 BILA:0000007 CARO:0000007 EHDAA2:0003007 FBbt:00007015 FMA:67112 HAO:0000007 TAO:0001835 TGMA:0001827 VHOG:0001727 immaterial physical anatomical entity uberon UBERON:0000466 immaterial anatomical entity Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. system AAO:0000007 AEO:0000011 BILA:0000011 BSA:0000049 CALOHA:TS-2088 CARO:0000011 EHDAA2:0003011 EHDAA:392 EMAPA:16103 EV:0100000 FBbt:00004856 FMA:7149 HAO:0000011 MA:0000003 OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ TAO:0001439 TGMA:0001831 UMLS:C0460002 VHOG:0001725 WBbt:0005746 WBbt:0005763 XAO:0003002 ZFA:0001439 galen:AnatomicalSystem body system connected anatomical system organ system uberon anatomical systems UBERON:0000467 anatomical system Anatomical structure that is an individual member of a species and consists of more than one cell. TODO - split body and mc organism? body continues after death stage organismal AAO:0010026 AEO:0000191 BILA:0000012 BSA:0000038 BTO:0000042 CARO:0000012 EFO:0002906 EHDAA2:0003103 EHDAA2:0003191 EHDAA:1 EHDAA:9178 EMAPA:25765 EV:0100016 FBbt:00000001 FMA:256135 HAO:0000012 TADS:0000001 TAO:0001094 TGMA:0001832 VHOG:0000671 WBbt:0007833 XAO:0003004 ZFA:0001094 galen:Organism ncithesaurus:Whole_Organism multi-cellular organism organism whole organism animal uberon Koerper body whole body UBERON:0000468 multicellular organism Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency AAO:0010053 AEO:0000032 BILA:0000032 CALOHA:TS-2084 CARO:0000032 EFO:0000808 EHDAA2:0003032 EMAPA:36031 FBbt:00007009 FMA:7153 HAO:0000032 MA:0002433 MAT:0000293 MESH:D001829 MIAA:0000293 OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA TAO:0001308 TGMA:0001840 UMLS:C0229962 VHOG:0001758 XAO:0003013 ZFA:0001308 galen:BodyPart anatomic region uberon body part body region cardinal body part UBERON:0000475 organism subdivision Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. AAO:0010268 AEO:0000040 BILA:0000040 CARO:0000040 EHDAA2:0003040 FBbt:00007013 FMA:63863 HAO:0000040 TAO:0000382 TGMA:0001841 XAO:0003162 ZFA:0000382 uberon acellular anatomical structures UBERON:0000476 acellular anatomical structure anatomical cluster Anatomical group that has its parts adjacent to one another. Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3] AAO:0010009 AEO:0000041 BILA:0000041 CARO:0000041 EHDAA2:0003041 FBbt:00007277 FMA:49443 HAO:0000041 TADS:0000605 TAO:0001478 TGMA:0001842 VHOG:0001737 XAO:0003160 ZFA:0001478 uberon UBERON:0000477 anatomical cluster Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. changed label and definition to reflect CARO2 AAO:0000607 AAO:0010054 AEO:0000043 BILA:0000043 CALOHA:TS-2090 CARO:0000043 EHDAA2:0003043 EMAPA:35868 FBbt:00007003 FMA:9637 HAO:0000043 MA:0003002 MESH:D014024 TAO:0001477 TGMA:0001844 UMLS:C0040300 VHOG:0001757 WBbt:0005729 XAO:0003040 ZFA:0001477 galen:Tissue portion of tissue tissue portion simple tissue uberon UBERON:0000479 tissue Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. AAO:0010048 AEO:0000055 BILA:0000055 CARO:0000055 EHDAA2:0003055 FBbt:00007010 HAO:0000055 TAO:0001488 TGMA:0001847 VHOG:0001762 XAO:0003037 ZFA:0001488 uberon multi-tissue structures UBERON:0000481 multi-tissue structure Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG] epithelial AAO:0000144 AAO:0010055 AEO:0000066 BILA:0000066 BTO:0000416 CALOHA:TS-0288 CARO:0000066 EHDAA2:0003066 EMAPA:32738 FBbt:00007005 FMA:9639 GAID:402 HAO:0000066 MA:0003060 MESH:D004848 TAO:0001486 UMLS:C0014609 VHOG:0000387 XAO:0003045 ZFA:0001486 epithelial tissue portion of epithelium uberon UBERON:0000483 epithelium Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] Epithelium that consists of more than one layer of epithelial cells.[CARO] AAO:0010059 AEO:0000069 BILA:0000069 BTO:0002074 CARO:0000069 EHDAA2:0003069 FMA:45562 HAO:0000069 TAO:0001494 UMLS:C0682575 XAO:0004006 ZFA:0001494 stratified epithelium uberon laminated epithelium UBERON:0000486 multilaminar epithelium Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA] Unilaminar epithelium that consists of a single layer of squamous cells.[CARO] AAO:0010066 AEO:0000070 BILA:0000070 BTO:0002073 CARO:0000070 EHDAA2:0003070 FMA:45565 HAO:0000070 TAO:0001498 UMLS:C0836133 XAO:0004010 ZFA:0001498 epithelium simplex squamosum uberon simple squamous epithelia UBERON:0000487 simple squamous epithelium Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA] consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable Epithelium that consists of a single layer of epithelial cells.[CARO] AAO:0010062 AEO:0000073 BILA:0000073 BTO:0002073 CARO:0000073 EHDAA2:0003073 FMA:45561 HAO:0000073 TAO:0001495 UMLS:C0682574 XAO:0004007 ZFA:0001495 simple epithelium uberon unilaminar epithelia UBERON:0000490 unilaminar epithelium Subdivision of trunk that lies between the head and the abdomen. note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest EMAPA:35862 FMA:259209 MA:0000022 thorax uberon anterior subdivision of trunk upper body upper trunk UBERON:0000915 thoracic segment of trunk Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. embryonic Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo AAO:0011035 AEO:0000169 BILA:0000056 BSA:0000039 BTO:0000379 CALOHA:TS-0229 EFO:0001367 EHDAA2:0000002 EHDAA2_RETIRED:0003236 EHDAA:38 EMAPA:16039 FBbt:00000052 FMA:69068 GAID:963 MAT:0000226 MESH:D004622 MIAA:0000019 OGEM:000001 OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA UMLS:C0013935 VHOG:0001766 XAO:0000113 ZFA:0000103 embryonic organism uberon developing organism developmental tissue UBERON:0000922 embryo A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] embryonic tissue AAO:0000480 BILA:0000035 BTO:0000556 EMAPA:36033 FBbt:00000110 FMA:69069 GAID:1303 MESH:A16.254.425 TAO:0001122 UMLS:C0920502 UMLS:C1708239 VHOG:0001223 XAO:0003011 ZFA:0001122 germinal layer primary germ layer uberon embryonic germ layer embryonic germ layers UBERON:0000923 Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] germ layer Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] ectodermal AAO:0000137 BILA:0000036 BTO:0000315 CALOHA:TS-0216 EFO:0000414 EHDAA2:0000428 EMAPA:16069 EV:0100003 FBbt:00000111 FMA:69070 GAID:1304 MAT:0000155 MAT:0000173 MESH:A16.254.425.273 MIAA:0000173 TAO:0000016 UMLS:C0013574 VHOG:0000153 XAO:0000001 ZFA:0000016 embryonic ectoderm uberon UBERON:0000924 ectoderm Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal AAO:0000139 BILA:0000038 BTO:0000800 CALOHA:TS-0273 EFO:0002545 EHDAA2:0000436 EMAPA:16062 EV:0100005 FBbt:00000125 FMA:69071 GAID:1305 MAT:0000175 MESH:A16.254.425.407 MIAA:0000175 TAO:0000017 UMLS:C0014144 VHOG:0000154 XAO:0000090 ZFA:0000017 uberon entoderm UBERON:0000925 endoderm The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] mesodermal sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates UBERON:0003263 AAO:0000304 BILA:0000037 BTO:0000839 CALOHA:TS-0623 EFO:0001981 EHDAA2:0001128 EHDAA:124 EHDAA:160 EHDAA:168 EHDAA:183 EMAPA:16083 EV:0100006 FBbt:00000126 FMA:69072 GAID:522 MAT:0000174 MESH:A16.254.425.660 MIAA:0000174 TAO:0000041 UMLS:C0025485 VHOG:0000152 XAO:0000050 ZFA:0000041 uberon embryonic mesoderm entire mesoderm mesodermal mantle UBERON:0000926 mesoderm Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO] the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx stomodeal This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity. stomodeal-hypophyseal primordium BTO:0004224 EHDAA2:0001929 EMAPA:16263 FBbt:00000439 FMA:295846 TAO:0001290 TGMA:0000135 UMLS:C1514977 XAO:0000269 ZFA:0001290 mouth primordium primitive oral cavity stomatodeum stomodaeum uberon mouth pit oral ectoderm oral pit UBERON:0000930 stomodeum A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO] Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO] relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG] cardiac AAO:0010210 BILA:0000020 BTO:0000562 CALOHA:TS-0445 EFO:0000815 EHDAA2:0000738 EHDAA:420 EMAPA:16105 EV:0100018 FMA:7088 GAID:174 MA:0000072 MAT:0000036 MESH:D006321 MIAA:0000036 OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA TAO:0000114 UMLS:C0018787 VHOG:0000276 XAO:0000064 ZFA:0000114 galen:Heart chambered heart vertebrate heart branchial heart uberon Herz@de cardium UBERON:0000948 Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" http://dx.doi.org/10.1101/gad.1485706 heart Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO] Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO] articulation joint AEO:0000182 BTO:0001686 CALOHA:TS-2023 EFO:0000948 EMAPA:35456 FMA:7490 GAID:102 MA:0000319 MAT:0000188 MESH:D007596 MIAA:0000188 OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0003182 TAO:0000367 UMLS:C0022417 VHOG:0001276 VSAO:0000101 XAO:0000171 ZFA:0001596 galen:Joint uberon articular joint joints UBERON:0000982 skeletal joint The outer epithelial layer of the skin that is superficial to the dermis. A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO] The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO] relationship loss: subclass external integument structures (AAO:0000961)[AAO] (...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG] epidermal Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes). epidermis skin AAO:0000143 BTO:0000404 CALOHA:TS-0283 EFO:0000954 EMAPA:17528 EV:0100153 FMA:70596 GAID:932 MA:0000153 MAT:0000154 MESH:D004817 MIAA:0000154 TAO:0000105 UMLS:C0014520 VHOG:0000077 XAO:0000028 ZFA:0000105 vertebrate epidermis uberon UBERON:0001003 skin epidermis Functional system which consists of structures involved in respiration. The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] AAO:0000541 BTO:0000203 CALOHA:TS-1319 EFO:0000804 EHDAA2:0001604 EHDAA:2203 EMAPA:16727 EV:0100036 FMA:7158 GAID:78 MA:0000327 MAT:0000030 MESH:D012137 MIAA:0000030 OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA TAO:0000272 UMLS:C0035237 VHOG:0000202 XAO:0000117 ZFA:0000272 apparatus respiratorius respiratory system uberon Atmungssystem apparatus respiratorius systema respiratorium UBERON:0001004 respiratory system Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO] digestive many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class AAO:0000129 BILA:0000082 BTO:0000058 CALOHA:TS-1293 EFO:0000793 EV:0100056 FBbt:00005055 FMA:7152 GAID:278 MA:0002431 MAT:0000018 MESH:D004064 MIAA:0000018 TADS:0000170 TAO:0000339 WBbt:0005748 XAO:0000125 ZFA:0000339 galen:DigestiveSystem ncithesaurus:Digestive_System uberon alimentary system alimentary tract gastrointestinal system gut UBERON:0001007 digestive system The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.. In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO] Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG] In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans AAO:0010257 BILA:0000015 BTO:0001244 BTO:0003092 CALOHA:TS-1323 EFO:0000803 EHDAA2:0001601 EHDAA:5901 EMAPA:17366 EV:0100095 FBbt:00005056 FMA:7159 GAID:391 MA:0000325 MAT:0000027 MESH:D014551 MIAA:0000027 TADS:0000162 TAO:0000163 UMLS:C1508753 VHOG:0000723 WBbt:0005736 XAO:0000143 ZFA:0000163 galen:UrinaryTract excretory system renal system systema urinaria systema urinarium urinary system urinary tract uberon renal or urinary system renal/urinary system UBERON:0001008 renal system organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. the cardiovascular system and the lymphatic system are parts of the circulatory system Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO] We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] AAO:0000959 CALOHA:TS-2103 FBbt:00005057 OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA VHOG:0001248 uberon systema cardiovasculare UBERON:0001009 circulatory system Portion of connective tissue composed of adipocytes enmeshed in areolar tissue Connective tissue in which fat is stored.[TAO] Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO] relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG] adipose In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen. in FMA this is dense irregular connective tissue AAO:0000001 AEO:000020 BTO:0001487 CALOHA:TS-0013 EFO:0000790 EHDAA2:0003120 EMAPA:35112 EV:0100381 FMA:20110 GAID:920 MA:0000009 MAT:0000015 MESH:D000273 MIAA:0000015 OpenCyc:Mx4rvVjc_ZwpEbGdrcN5Y29ycA TAO:0002134 UMLS:C0001527 VHOG:0001284 XAO:0003049 ZFA:0005345 galen:FattyTissue fat fat tissue fatty tissue uberon adipose bodyfat fatty depot UBERON:0001013 adipose tissue A subdivision of the muscular system corresponding to a subdisivision of an organism. In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here. AAO:0011066 BTO:0000887 EFO:0001949 EMAPA:32715 EMAPA:35577 FMA:32558 MA:0000165 OpenCyc:Mx4rvVjmr5wpEbGdrcN5Y29ycA TAO:0000548 UMLS:C0026845 VSAO:0005038 WBbt:0005737 ZFA:0000548 muscle group muscles set musculature musculi set of muscles set of skeletal muscles uberon muscle system muscles musculature system UBERON:0001015 musculature The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO] Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO] Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] nervous neural AAO:0000324 BILA:0000079 BTO:0001484 CALOHA:TS-1313 EFO:0000802 EHDAA2:0001246 EHDAA:826 EMAPA:16469 EV:0100162 FBbt:00005093 FMA:7157 GAID:466 MA:0000016 MAT:0000026 MESH:D009420 MIAA:0000026 OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA TAO:0000396 UMLS:C0027763 VHOG:0000402 WBbt:0005735 XAO:0000177 ZFA:0000396 neurological system nerve net uberon systema nervosum UBERON:0001016 nervous system The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] The brain and spinal cord. Kimmel et al, 1995.[TAO] The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] AAO:0000090 BAMS:CNS BILA:0000080 BTO:0000227 CALOHA:TS-0150 EFO:0000908 EHDAA2:0000225 EHDAA:828 EMAPA:16470 EMAPA:16754 EV:0100163 FBbt:00005094 FMA:55675 GAID:570 MA:0000167 MAT:0000457 MESH:D002490 OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA TAO:0000012 UMLS:C0927232 VHOG:0000293 XAO:0000215 ZFA:0000012 CNS systema nervosum centrale cerebrospinal axis uberon neuraxis UBERON:0001017 central nervous system Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. AEO:0000171 BTO:0001886 EFO:0001652 EHDAA2:0003171 FBbt:00005495 FMA:86589 MAT:0000482 UMLS:C0678727 XAO:0003043 uberon bud future organ placode primordia rudiment UBERON:0001048 primordium In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO] The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium AAO:0010617 BTO:0001057 CALOHA:TS-2371 DHBA:10154 EHDAA2:0001254 EHDAA:2869 EHDAA:908 EMAPA:16164 EMAPA:16530 EMAPA:16757 FMA:293882 MAT:0000069 MIAA:0000069 TAO:0001135 UMLS:C0231024 VHOG:0000307 XAO:0003204 ZFA:0001135 uberon neural primordium presumptive central nervous system tubus neuralis UBERON:0001049 neural tube Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. AAO:0010841 AEO:0000000 BILA:0000000 CARO:0000000 EHDAA2:0002229 FBbt:10000000 FBbt_root:00000000 FMA:62955 HAO:0000000 MA:0000001 TAO:0100000 TGMA:0001822 UMLS:C1515976 XAO:0000000 ZFA:0100000 uberon UBERON:0001062 anatomical entity Transudate contained in the synovial cavity of joints, and in the cavity of tendon sheaths and bursae. Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO] BTO:0001339 CALOHA:TS-0996 ENVO:02000039 FMA:12277 GAID:265 MA:0002544 MESH:D013582 TAO:0005154 UMLS:C0039097 ZFA:0005154 galen:SynovialFluid joint fluid uberon UBERON:0001090 synovial fluid Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. http://en.wikipedia.org/wiki/ The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). AEO:0000111 BTO:0002422 CALOHA:TS-1183 EHDAA2_RETIRED:0003111 EHDAA:2331 EHDAA:2349 EHDAA:295 EHDAA:6073 EHDAA:640 EHDAA:646 EMAPA:32856 FMA:14074 MA:0000565 UMLS:C0086610 uberon UBERON:0001136 mesothelium Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO] Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO] System that provides physical support to the organism.[AAO] By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG] skeletal GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates AAO:0000566 BTO:0001486 CALOHA:TS-1320 EFO:0000806 EHDAA2:0003168 EMAPA:35773 FMA:23881 MA:0000018 OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA TAO:0000434 UMLS:C0037253 VHOG:0001254 VSAO:0000027 XAO:0003060 ZFA:0000434 skeleton system set of all bones and joints uberon Skelettsystem UBERON:0001434 skeletal system https://github.com/obophenotype/uberon/wiki/The-skeletal-system Skeletal element that is composed of bone tissue. Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO] Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO] Skeletal element that is composed of bone tissue.[VSAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG] AAO:0000047 AEO:0000082 BTO:0000140 CALOHA:TS-0088 EFO:0000298 EHDAA2:0003082 EMAPA:32782 ENVO:00002039 EV:0100140 FMA:30317 FMA:5018 GAID:92 MA:0001459 MAT:0000299 MIAA:0000299 OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA TAO:0001514 UMLS:C0262950 VHOG:0001190 VSAO:0000057 XAO:0000169 ZFA:0001514 galen:Bone bone element bone organ uberon bone bones UBERON:0001474 bone element An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. check ncita FMA:34836 GAID:263 MA:0001519 MESH:D017746 UMLS:C0206207 galen:JointCapsule capsula articularis fibrous capsule of joint joint capsule joint fibrous capsule uberon capsulae articulares UBERON:0001484 articular capsule A tube extending from the mouth to the anus. The alimentary or digestive tract, and associated organs.[TAO] The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] FMA also has a term 'gastrointestinal tract', but this includes the liver. we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509 we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this gut AAO:0010023 BILA:0000083 BTO:0000511 BTO:0000545 EHDAA2:0000726 EHDAA:518 EMAPA:16247 FBbt:00003125 FMA:45615 MA:0000917 OpenCyc:Mx4rvVi0GpwpEbGdrcN5Y29ycA TAO:0000112 TGMA:0001819 UMLS:C0017189 VHOG:0000309 WBbt:0005743 ZFA:0000112 galen:AlimentaryTract digestive tube enteric tract alimentary canal alimentary tract uberon digestive canal gut tube UBERON:0001555 digestive tract Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. Portion of tissue composed of contractile fibers.[TAO] It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG] muscular muscle AAO:0011066 EMAPA:32715 EV:0100146 FMA:5022 GAID:131 MA:0000015 OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA TAO:0005145 VHOG:0001245 XAO:0000172 ZFA:0005145 galen:Muscle uberon UBERON:0001630 muscle organ The liquid component of blood, in which erythrocytes are suspended. plasma portion of plasma BTO:0000131 CALOHA:TS-0800 EFO:0001905 EMAPA:35690 FMA:62970 GAID:1178 MA:0002501 MAT:0000052 MESH:D010949 MIAA:0000052 OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw UMLS:C0032105 blood plasm portion of blood plasma uberon UBERON:0001969 blood plasma A vessel through which blood circulates in the body. consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG] Any of the vessels through which blood circulates in the body.[AAO] The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] annelids have blood vessels, but this class is not applicable to annelids. FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX vascular element AAO:0011004 AEO:0000207 BTO:0001102 CALOHA:TS-0080 EFO:0000817 EHDAA2:0003252 EHDAA:240 EMAPA:32743 EMAPA:35993 FMA:50722 FMA:63183 GAID:169 MA:0000060 MAT:0000393 MESH:D001808 OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA TAO:0002137 UMLS:C0005847 VHOG:0001250 XAO:0001011 ZFA:0005314 region of vascular tree organ vascular tree organ region uberon vas sanguineum UBERON:0001981 blood vessel An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. see also: vascular system. Consider merging? vascular BTO:0003718 FMA:69050 TAO:0005249 ZFA:0005249 vascular network uberon UBERON:0002049 vasculature Anatomical structure that is part of an embryo. Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO] Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO] Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO] in FMA embryo is_a embryonic structure AAO:0000138 BILA:0000034 BTO:0000174 CALOHA:TS-2110 EFO:0000461 FBbt:00004208 FMA:69067 GAID:407 MESH:D004628 RETIRED_EHDAA2:0003169 TAO:0001105 UMLS:C0013948 VSAO:0000178 XAO:0003042 ZFA:0001105 developing embryonic structure embryonic anatomical structure uberon developing structure embryonale Struktur embryonic structures UBERON:0002050 embryonic structure The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. Consider adding a layer-of-skin grouping class for all skin layers A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] dermal AAO:0000128 BTO:0000294 CALOHA:TS-2076 EFO:0000953 EMAPA:17527 EV:0100154 FMA:70323 GAID:1321 MA:0000152 MAT:0000153 MESH:D020405 MIAA:0000153 TAO:0001119 UMLS:C0011646 VHOG:0000108 XAO:0000217 ZFA:0001119 vertebrate dermis uberon corium cutis UBERON:0002067 dermis Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO] A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]. hypodermal subcutaneous subcutaneus BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument. BTO:0001314 CALOHA:TS-2366 FMA:70544 TAO:0001136 UMLS:C0278403 ZFA:0001136 hypoderm vertebrate hypodermis uberon sub-tegumental tissue subcutaneous tissue subcutis subtegumental tissue superficial fascia tela subcutanea UBERON:0002072 hypodermis The post-cranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO] The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO] The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO] The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG] axial skeleton AAO:0000034 EFO:0000942 EHDAA2:0000161 EHDAA:5049 EMAPA:17214 FMA:71221 MA:0002986 MAT:0000148 MIAA:0000148 TAO:0000317 VHOG:0000317 VSAO:0000093 XAO:0003073 ZFA:0000317 post-cranial axial skeleton uberon UBERON:0002090 previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. postcranial axial skeleton http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton The organ covering the body that consists of the dermis and epidermis. consider 'integumentary system' for invertebrates MA uses the term skin to refer to what is called here: zone of skin BTO:0001253 CALOHA:TS-0934 EFO:0000962 EHDAA2:0001844 EMAPA:17525 FMA:7163 MESH:D012867 MFMO:0000099 OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA UMLS:C1123023 XAO:0000023 galen:Skin entire skin skin organ uberon entire integument integument integumental organ pelt skin UBERON:0002097 skin of body Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO] Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO] AAO:0010339 BILA:0000116 BTO:0001493 CALOHA:TS-1071 EFO:0000966 EMAPA:31857 FMA:7181 MA:0000004 MAT:0000296 MIAA:0000296 OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA TAO:0001115 UMLS:C0460005 XAO:0000054 XAO:0003025 ZFA:0001115 galen:Trunk thoracolumbar region torso trunk region uberon Rumpf UBERON:0002100 trunk Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. CALOHA:TS-2018 EHDAA2:0004615 EMAPA:18765 FMA:74562 MA:0000013 hematolymphoid system lymphomyeloid complex uberon haemolymphoid system UBERON:0002193 hemolymphoid system The dermis, epidermis and hypodermis. in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition. Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO] Surface structure that is the outer protective covering of the body.[VSAO] The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO] integumental integumentary AAO:0000239 BTO:0000634 FMA:74657 TAO:0000368 VSAO:0000029 ZFA:0000368 galen:Integument dermis plus epidermis plus hypodermis integumentum commune skin and subcutaneous tissue skin plus hypodermis the integument uberon Hautsystem@de dermal system dermoid system skin tegument vertebrate integument UBERON:0002199 integument Anatomical system that consists of the muscular and skeletal systems. Anatomical system that provides locomotion and physical support to the organism.[AAO] There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG] musculoskeletal AAO:0010546 CALOHA:TS-1311 EMAPA:32714 EV:0100139 FMA:7482 GAID:98 MA:0002418 MESH:D009141 OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g UMLS:C0026860 VHOG:0001275 VSAO:0000031 XAO:0000168 musculo-skeletal system uberon UBERON:0002204 musculoskeletal system Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA] Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO] AEO:0000183 CALOHA:TS-2138 EHDAA2:0003183 FMA:7501 MA:0000322 OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA TAO:0005153 ZFA:0005153 galen:SynovialJoint articulatio synoviale diarthroses diarthrosis diarthrosis joint uberon diarthrodial joints UBERON:0002217 synovial joint The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. In many species, the diaphragm separates thoracic and abdominal cavities EMAPA:36497 FMA:7565 GAID:93 MA:0000032 MESH:A01.911.800 OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA UMLS:C0230139 cavitas thoracis cavity of chest cavity of thorax chest cavity pectoral cavity space of thoracic compartment thoracic lumen uberon UBERON:0002224 thoracic cavity The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. check the FMA placement here; ncit placement of body cavity here probably not correct Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA]. The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]. In mammals it forms the peritoneal, pleural, and pericardial cavities UBERON:0000169 body cavity AEO:0000186 BTO:0001707 EHDAA2:0000267 FBbt:00005060 FMA:85006 RETIRED_EHDAA2:0003186 TAO:0001438 UMLS:C0333343 ZFA:0001438 galen:BodyCavity coelomic cavity coelomic cavity lumen main body cavity space of body compartment ventral body cavity uberon celom coelom coelome hemocoel UBERON:0002323 coelemic cavity lumen A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO] Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO] Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO] relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG] notochordal In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord. AAO:0000327 BTO:0001768 CALOHA:TS-0690 EHDAA2:0001277 EHDAA:1241 EHDAA:6021 EMAPA:16191 EV:0100002 FMA:85521 GAID:1311 MAT:0000281 MESH:A16.254.610 TAO:0000135 UMLS:C0028439 VHOG:0000199 VSAO:0000032 XAO:0000055 ZFA:0000135 embryonic notocord notocord uberon notochorda UBERON:0002328 The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] notochord Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk Post-cranial axial segments which form sclerotome and dermomyotome.[AAO] Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO] relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO] relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO] relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO] (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG] somitic mesodermal cluster AAO:0010569 AEO:0001015 BTO:0001558 EHDAA2:0003436 EHDAA:366 EHDAA:699 EMAPA:31169 FMA:85522 GAID:1306 MAT:0000068 MESH:A16.254.425.660.750 MIAA:0000068 TAO:0000155 UMLS:C0376449 VHOG:0000191 XAO:0000058 ZFA:0000155 uberon epimere epimere mesoderm epithelial somite somites somitic mesoderm somitus UBERON:0002329 When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] somite Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. CALOHA:TS-2057 EHDAA2:0002225 EMAPA:35329 FMA:85539 MA:0002411 UMLS:C1516995 WikipediaCategory:Exocrine_system exocrine glandular system uberon UBERON:0002330 exocrine system A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO] Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO] A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831] We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG] AAO:0010578 BTO:0001764 CALOHA:TS-0676 EHDAA2:0004419 EMAPA:32737 FMA:86666 GAID:1310 MAT:0000066 MESH:A16.254.600 MIAA:0000066 TAO:0000045 UMLS:C0027789 VHOG:0000057 XAO:0000048 ZFA:0000045 NC uberon crista neuralis neural crest material UBERON:0002342 Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. neural crest Embryonic ectoderm that gives rise to nervous tissue. (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG] neurectodermal we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here AAO:0011074 BILA:0000039 CALOHA:TS-1212 EHDAA2:0001248 EHDAA:1498 EHDAA:255 EMAPA:16073 EV:0100004 FBbt:00001061 FMA:87657 MAT:0000176 MIAA:0000176 TAO:0001120 UMLS:C1518271 VHOG:0000150 XAO:0000042 ZFA:0001120 neural ectoderm neuroectoderm uberon epithelium tubi neuralis; neuroectoderma neuaral ectoderm presumptive central nervous system ventral neurogenic region UBERON:0002346 neurectoderm A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses AEO:0000097 BTO:0000765 CALOHA:TS-2012 EHDAA2:0003097 EMAPA:35327 FMA:9596 GAID:34 MA:0002564 MESH:D005088 UMLS:C0015282 ducted gland glandula exocrina uberon UBERON:0002365 exocrine gland Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO] Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO] Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO] MA also has set of connective tissues AAO:0000098 BTO:0000421 CALOHA:TS-2009 EFO:0000952 EMAPA:35251 FMA:9640 GAID:100 MA:0000011 MAT:0000301 MESH:D003238 MIAA:0000301 OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA TAO:0001641 UMLS:C0009780 VSAO:0000017 XAO:0001017 ZFA:0001632 galen:ConnectiveTissue portion of connective tissue textus connectivus uberon Bindegewebe UBERON:0002384 connective tissue Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] AAO:0000306 AEO:0000122 CALOHA:TS-0642 EHDAA2:0003122 EMAPA:32715 FMA:9641 MA:0002437 MESH:D009132 UMLS:C2328219 galen:MuscleTissue muscular tissue portion of muscle tissue textus muscularis uberon UBERON:0002385 Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. muscle tissue Anatomical system that is involved in the production of hematopoietic cells. Anatomical system that consists of the blood and blood forming tissues.[AAO] Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG] hematopoietic In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes AAO:0011002 BTO:0000570 CALOHA:TS-0449 EFO:0000798 EMAPA:35402 EV:0100045 FMA:9667 GAID:1008 MA:0002434 MAT:0000022 MESH:D006413 MIAA:0000022 TAO:0005023 UMLS:C0018957 VHOG:0001624 XAO:0000122 ZFA:0005023 haematological system haemopoietic system organa haemopoietica uberon Blutbildungssystem haematopoietic system hematological system hematolymphoid system hemopoietic system UBERON:0002390 hematopoietic system Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] UBERON:0007029 AEO:0000154 BILA:0000118 CALOHA:TS-1299 CARO:0002001 EFO:0000807 EHDAA2:0000836 EHDAA2_RETIRED:0003154 EHDAA:6520 EMAPA:17524 EV:0100151 FBbt:00004969 FMA:72979 HAO:0000421 MA:0000014 MAT:0000033 MESH:D034582 MIAA:0000033 TADS:0000108 UMLS:C0037267 VHOG:0000403 XAO:0000176 galen:Surface integumentary system uberon body surface dermal system external covering of organism integumentum commune organism surface surface UBERON:0002416 integumental system The abdominal segment of the torso. EMAPA:35104 FMA:259211 MA:0000021 uberon abdomen/pelvis/perineum lower body lower trunk lumbar region UBERON:0002417 abdominal segment of trunk Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. see https://github.com/obophenotype/uberon/issues/27 Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO] CALOHA:TS-2011 EMAPA:35179 FMA:224804 MA:0002780 MESH:D001842 UMLS:C0391978 VSAO:0000047 XAO:0004040 ZFA:0005621 galen:BoneTissue calcium tissue osseous tissue osteogenic tissue mineralized bone tissue uberon bone portion of bone tissue UBERON:0002481 bone tissue an organ that functions as a secretory or excretory organ glandular UBERON:MIAA_0000021 AAO:0000212 AEO:0000096 BTO:0000522 EFO:0000797 EHDAA2:0003096 EHDAA:2161 EHDAA:4475 EHDAA:6522 EMAPA:18425 FBbt:00100317 FMA:7146 FMA:86294 HAO:0000375 MA:0003038 MAT:0000021 MIAA:0000021 OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA UMLS:C1285092 WikipediaCategory:Glands galen:Gland glandular organ uberon Druese glandula UBERON:0002530 gland In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA] MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG] BTO:0004593 FMA:296704 MAT:0000067 MIAA:0000067 VHOG:0000243 epiblast uberon blastocyst ectoblast epiblastus primitive ectoderm UBERON:0002532 epiblast (generic) Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. cavity FMA:67552 MA:0002447 galen:Cavity uberon UBERON:0002553 anatomical cavity A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO] relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO] In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP] In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html) EHDAA2:0001846 EHDAA:6538 FMA:295662 TAO:0001185 UMLS:C1518973 VHOG:0001680 XAO:0000029 ZFA:0001185 skin periderm uberon EVL epidermis epithelial layer epidermis outer layer epitrichium periderm UBERON:0003055 periderm Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] AAO:0011086 EFO:0001982 EMAPA:16189 EMAPA:16752 TAO:0000279 VHOG:0000559 XAO:0000057 ZFA:0000279 segmental plate unsegmented paraxial mesoderm uberon PSM presumptive somite mesoderm somitogenic mesoderm somitomeric mesoderm unsegmented mesenchyme UBERON:0003059 presomitic mesoderm Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO] Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO] relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO] Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG] EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac ventral lateral plate mesoderm AAO:0011006 EFO:0003489 EHDAA:207 TAO:0000094 TE:E5.11.2.0.0.0.4 UMLS:C1511224 VHOG:0000085 XAO:0000067 ZFA:0000094 blood islands uberon VBI caudal hematopoietic tissue posterior ICM posterior blood island ventral blood island UBERON:0003061 blood island The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] AAO:0011017 EFO:0003647 TAO:0001204 VHOG:0000107 XAO:0000205 ZFA:0001204 uberon chordamesoderm UBERON:0003068 axial mesoderm A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011072 BTO:0001765 DHBA:10153 DMBA:15565 EHDAA:346 EHDAA:902 EMAPA:35593 FMA:293879 RETIRED_EHDAA2:0001252 TAO:0000132 UMLS:C0920623 VHOG:0000068 XAO:0000249 ZFA:0000132 uberon lamina neuralis presumptive central nervous system UBERON:0003075 neural plate The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO] Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here) AAO:0010568 EFO:0003515 EMAPA:16183 EMAPA:16751 FMA:293145 TAO:0000255 UMLS:C1284009 VHOG:0000114 XAO:0000259 ZFA:0000255 paraxial mesenchyme somitic mesoderm uberon mesoderma paraxiale UBERON:0003077 paraxial mesoderm Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO] The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] subclass of mesoderm in ZFA. UBERON:0006258 AAO:0010574 EHDAA2:0000919 EHDAA:379 EMAPA:16179 FMA:293149 TAO:0000121 UMLS:C1517749 VHOG:0000118 XAO:0000311 ZFA:0000121 LPM lateral mesoderm uberon lateral plate lateral plate mesenchyme mesoderma laminae lateralis UBERON:0003081 lateral plate mesoderm Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. should probably be merged with heart rudiment. Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO] relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO] AAO:0011044 BTO:0001887 TAO:0000028 UMLS:C1514450 XAO:0000336 ZFA:0000028 uberon cardiac field fused heart primordium UBERON:0003084 heart primordium Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] part_of somite in XAO AAO:0010571 AEO:0000212 EHDAA2:0003439 EMAPA:31159 FMA:295652 TAO:0001080 UMLS:C0183176 VHOG:0000680 XAO:0000397 ZFA:0001080 sclerotomes uberon sclerotomus UBERON:0003089 sclerotome Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] AAO:0010337 AEO_RETIRED:0000010 EHDAA2_RETIRED:0003010 TAO:0000292 VSAO:0000001 XAO:0003028 ZFA:0000292 galen:SurfaceRegion anatomical surface feature uberon surface feature surface region surface structures UBERON:0003102 surface structure Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs AAO:0010015 AEO:0000024 BILA:0000024 CARO:0000024 EHDAA2:0003024 HAO:0000024 TADS:0000598 TAO:0000496 TGMA:0001837 VHOG:0001723 XAO:0003041 ZFA:0000496 uberon organ UBERON:0003103 compound organ Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO]. the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO] Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO] mesenchymal AAO:0010427 AEO:0000145 BTO:0001393 CALOHA:TS-0620 EHDAA2:0003145 EV:0100007 TAO:0000393 UMLS:C0162415 VHOG:0000170 XAO:0003046 ZFA:0000393 mesenchymal tissue mesenchyme tissue portion of mesenchymal tissue portion of mesenchyme tissue uberon mesenchyma UBERON:0003104 mesenchyme Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] FMA definition includes vasculature AAO:0000325 AEO:0000123 EHDAA2:0003123 FMA:9642 GAID:609 MESH:D009417 OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ UMLS:C0027757 nerve tissue nervous tissue portion of neural tissue uberon UBERON:0003714 neural tissue An anatomical cavity that has the potential to develop into a coelemic cavity lumen. uberon body cavity precursor UBERON:0003886 future coelemic cavity lumen The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] EHDAA:251 EMAPA:16088 UMLS:C1512940 VHOG:0000316 somatic coelom uberon UBERON:0003887 intraembryonic coelom Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers AEO:0000114 EHDAA2:0003114 FBbt:00007474 epithelial or endothelial tube uberon UBERON:0003914 epithelial tube A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. Not to be confused with 'dermatome segment of skin'. AAO:0011028 AEO:0001017 EHDAA2_RETIRED:0003428 EHDAA:1719 EHDAA:1725 EHDAA:1731 EHDAA:1737 EMAPA:32838 FMA:295656 UMLS:C0180383 XAO:0000220 cutis plate dermatomal mesenchyme uberon epimere mesoderm mesenchyma dermatomiale UBERON:0004016 dermatome 2 2 Any tube, opening or passage that connects two distinct anatomical spaces. FMA has both conduit and conduit space. In EHDAA2 this is a surface feature AEO:0000080 EHDAA2:0003080 FMA:242873 foramen foramina uberon opening ostia ostium UBERON:0004111 anatomical conduit An anatomical structure that develops (entirely or partially) from the mesoderm. Grouping term for query purposes uberon UBERON:0004120 mesoderm-derived structure An anatomical structure that develops (entirely or partially) from the ectoderm. Grouping term for query purposes uberon UBERON:0004121 ectoderm-derived structure The first recognizable structure derived from the heart field TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO (In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG] EHDAA2:0000215 EMAPA:16106 VHOG:0000975 myocardial plate uberon cardiac crescent cardiogenic crescent heart rudiment UBERON:0004139 cardiogenic plate A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] XAO:0004185 first heart field primary heart field uberon FHF PHF heart field UBERON:0004140 primary heart field An epithelial tube that will give rise to the mature heart. the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. AAO:0010411 EFO:0003526 EMAPA:32685 TAO:0000360 XAO:0000337 ZFA:0000360 embryonic heart tube endocardial heart tube endocardial tube uberon UBERON:0004141 heart tube A cardiac chamber surrounds an enclosed cavity within the heart FMA:7095 OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw chamber of heart heart chamber uberon UBERON:0004151 generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus cardiac chamber Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO] skeletal AEO:0000168 EHDAA2:0001843 EHDAA:5047 EMAPA:17213 FMA:23875 GAID:177 MA:0003006 MAT:0000032 MESH:D012863 MIAA:0000032 OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA VSAO:0000026 XAO:0004053 galen:Skeleton set of all bones set of bones of body uberon UBERON:0004288 skeleton https://github.com/obophenotype/uberon/wiki/The-skeletal-system The bilaminar epithelium formed from the myotome and dermatome. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] Portion of somites that gives rise to dermis and muscles.[AAO] all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis. Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG] AAO:0010572 AEO:0000214 EHDAA2:0003259 EMAPA:31109 FMA:295654 TAO:0001513 UMLS:C1511786 VHOG:0000676 ZFA:0001513 uberon dermamyotome dermomyotomes UBERON:0004290 dermomyotome A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO] TAO:0000115 ZFA:0000115 heart cone rudimentary heart uberon UBERON:0004291 heart rudiment Anatomical system that has as its parts the heart and blood vessels. we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph. The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG] AAO:0011001 BILA:0000016 BTO:0000088 CALOHA:TS-1297 EFO:0000791 EHDAA2:0000216 EHDAA:394 EMAPA:16104 EMAPA:16370 EV:0100017 FMA:7161 GAID:467 MA:0000010 MAT:0000016 MESH:D002319 MIAA:0000016 OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA TAO:0000010 UMLS:C0007226 VHOG:0000302 WikipediaCategory:Cardiovascular_system XAO:0000100 XAO:0001010 ZFA:0000010 uberon CV system Herz und Gefaesssystem UBERON:0004535 cardiovascular system A vascular network consisting of blood vessels. TAO:0001079 ZFA:0001079 blood vascular network set of blood vessels uberon blood system blood vessel system blood vessels UBERON:0004537 blood vasculature The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus AEO:0000194 BTO:0003834 EHDAA2:0000001 EHDAA2:0003235 EMAPA:36040 UMLS:C1516779 embryo plus adnexa uberon UBERON:0004716 conceptus Organism at the gastrula stage. We explicitly merge the NCITA terms here UBERON:0007012 BILA:0000060 BTO:0001403 FBbt:00005317 FMA:293108 GAID:1302 MESH:A16.254.412 MIAA:0000179 UMLS:C0017199 UMLS:C1284022 gastrula embryo uberon blastocystis trilaminaris tri-laminar disc tri-laminar disk trilaminar blastocyst trilaminar blastoderm trilaminar disc trilaminar disk trilaminar germ UBERON:0004734 gastrula A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] MA:0003047 VSAO:0000015 XAO:0004038 ZFA:0005619 uberon UBERON:0004755 Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] AAO:0011129 TAO:0001890 VSAO:0000128 XAO:0004012 ZFA:0005494 galen:SkeletalStructure uberon UBERON:0004765 skeletal element Anatomical system that consists of all the joints of the body. EMAPA:35150 FMA:23878 MA:0003007 VSAO:0000181 joint system set of all joints of body uberon set of all joints set of joints of body UBERON:0004770 articular system Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors visceral mesoderm AAO:0011102 BILA:0000044 FMA:295568 XAO:0000276 inner layer of lateral plate mesoderm uberon splanchnic mesoderm UBERON:0004872 splanchnic layer of lateral plate mesoderm The central region of trunk mesoderm. This tissue forms the notochord Notochord rudiment[ZFIN:ZDB-PUB-961014-576]. WP treats this as synonym of axial mesoderm. Induces neural tube. Gilbert: contains an anterior head process and the notochord. AAO:0000478 EFO:0003426 TAO:0000091 ZFA:0000091 axial chorda mesoderm chorda mesoderm dorsal mesoderm presumptive notochord uberon UBERON:0004880 chordamesoderm Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. FBbt:00005811 joint uberon UBERON:0004905 articulation A proximal-distal subdivision of the digestive tract. intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct. FBbt:00100315 FMA:71131 uberon alimentary system subdivision intestinal tract segment of intestinal tract subdivision of alimentary system UBERON:0004921 subdivision of digestive tract A part of a wall of an organ that forms a layer. FMA:82485 uberon UBERON:0004923 organ component layer The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]. AAO:0011071 EMAPA:35594 FMA:295624 UMLS:C0814992 XAO:0000248 uberon UBERON:0005061 neural groove One of the two elevated edges of the neural groove[GO,MP]. In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]. EHDAA2:0001249 EMAPA:16142 EMAPA:16146 EMAPA:16151 EMAPA:16155 EMAPA:16159 EMAPA:16162 EMAPA:16288 EMAPA:16292 EMAPA:16295 EMAPA:16299 EMAPA:16303 EMAPA:16307 EMAPA:16528 FMA:295618 UMLS:C0814993 XAO:0004087 medullary fold uberon UBERON:0005062 neural fold A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO] EFO:0003498 TAO:0000133 ZFA:0000133 uberon neural tube rod UBERON:0005068 neural rod Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila EMAPA:32715 FBbt:00005073 FMA:30316 musculus uberon muscle muscle element UBERON:0005090 muscle structure An epithelial sheet bent on a linear axis. uberon UBERON:0005157 epithelial fold An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. MA:0000516 trunk organ uberon UBERON:0005177 trunk region element An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. MA:0000557 thoracic cavity organ uberon UBERON:0005178 thoracic cavity element An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. MA:0000563 uberon upper body organ UBERON:0005181 thoracic segment organ Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 EHDAA:377 EMAPA:16177 TAO:0000081 VHOG:0000281 ZFA:0000081 uberon trunk and cervical mesenchyme UBERON:0005256 trunk mesenchyme A portion of tissue that is part of an embryo. CALOHA:TS-2100 portion of embryonic tissue uberon developing tissue UBERON:0005291 embryonic tissue AEO:0000125 CALOHA:TS-2122 EHDAA2:0003125 FBbt:00007006 FMA:292313 MIAA:0000019 uberon developing structure developmental structure developmental tissue UBERON:0005423 developing anatomical structure Multi-tissue structure that arises from the heart rudiment and will become the heart tube. EHDAA2:0001512 EHDAA:424 EHDAA:436 EMAPA:16208 EMAPA:16215 FMA:321916 TAO:0000149 ZFA:0000149 primitive heart tube early primitive heart tube uberon UBERON:0005498 primitive heart tube A acellular anatomical structure that is the bounding layer of a anatomical structure. FMA:63871 uberon UBERON:0005764 acellular membrane An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. this class represents a continuous sheet of basement membrane which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal membrane' represents a portion of substance on the scale of a single cell. AAO:0010596 FMA:63872 GAID:915 UMLS:C0004799 basement membrane of connective tissue membrana basalis uberon basement membrane UBERON:0005769 basement membrane of epithelium A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 EHDAA:8979 mesenchyme condensation uberon UBERON:0005856 developing mesenchymal condensation Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA] EMAPA:16060 FMA:9689 MA:0000005 uberon UBERON:0005906 See notes for serous membrane serous sac Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO] AAO:0000963 EMAPA:17214 EMAPA:18043 MA:0000308 UMLS:C0222645 VSAO:0000056 XAO:0004011 uberon skeleton axiale UBERON:0005944 axial skeleton plus cranial skeleton http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] EHDAA2:0001278 EHDAA:264 EMAPA:16101 UMLS:C1518429 VHOG:0001212 uberon UBERON:0006267 notochordal plate A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot EHDAA2:0001279 EHDAA:224 EMAPA:16102 FMA:293135 UMLS:C1518430 VHOG:0001213 uberon chordamesoderm presumptive notochord UBERON:0006268 The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process bodily fluid Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. fluid FMA:280556 GAID:266 MESH:D001826 galen:BodyFluid body fluid uberon UBERON:0006314 bodily fluid The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. currently this is an extremely generic class, encompassing both protostomes and deuterostomes. branchial pharyngeal FBbt:00005380 MAT:0000049 MIAA:0000049 uberon anterior part of foregut pharyngeal tube UBERON:0006562 pharynx Presumptive structure of the blastula that will develop into endoderm. AAO:0000471 EFO:0003437 TAO:0000416 ZFA:0000416 uberon UBERON:0006595 presumptive endoderm AAO:0000468 EFO:0003439 TAO:0000568 ZFA:0000568 future blood uberon UBERON:0006596 presumptive blood Portion of embryonic tissue determined by fate mapping to become a structure. Consider merging with anlage AAO:0000479 TAO:0001116 ZFA:0001116 future structure presumptive structures uberon UBERON:0006598 presumptive structure Presumptive structure of the blastula that will develop into ectoderm. AAO:0000470 EFO:0003466 TAO:0001376 XAO:0004132 ZFA:0001376 uberon presumptive epidermis UBERON:0006601 presumptive ectoderm Presumptive structure of the blastula that will develop into mesoderm. AAO:0000476 EFO:0003467 TAO:0001377 ZFA:0001377 uberon UBERON:0006603 presumptive mesoderm An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium BTO:0002072 UMLS:C0221909 uberon UBERON:0006914 squamous epithelium The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. EFO:0003709 TAO:0005077 ZFA:0005077 uberon UBERON:0006965 vascular cord A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n AAO:0010270 BILA:0000010 CARO:0001002 EHDAA2:0003192 FMA:24137 ID:0000000 UMLS:C1515977 ZFA:0005594 uberon UBERON:0006984 Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. anatomical surface The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. consider FBbt:00005541 ! cardiogenic mesoderm review EHDAA2 placement AAO:0011021 BILA:0000051 EFO:0000315 EHDAA2:0000214 EHDAA:385 FMA:293143 VHOG:0001641 XAO:0000235 uberon cardiogenic mesoderm cardiogenic region heart primordia UBERON:0007005 cardiac mesoderm Organism at the cleavage stage. BILA:0000058 uberon UBERON:0007010 cleaving embryo The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis BILA:0000084 UMLS:C1514442 future digestive tract future digestive tube future gut primitive gut uberon embryonic digestive tube primordial digestive tube primordial gut UBERON:0007026 presumptive gut A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis FBbt:00003154 SPD:0000130 TADS:0000147 dorsal tube heart uberon adult heart UBERON:0007100 Gene notes: Bmp, Nkx, Gata primary circulatory organ An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO] EFO:0003497 TAO:0000131 ZFA:0000131 uberon presumptive central nervous system UBERON:0007135 neural keel Of or pertaining to the period of time immediately following birth, or to the newborn. consider splitting infant/newborn BTO:0001762 EV:0300037 HsapDv:0000082 MmusDv:0000096 NIF_Organism:birnlex_695 OGES:000025 neonatal stage fledgling stage hatchling hatchling stage infant stage nestling stage pouch stage puggle puggle stage uberon newborn stage UBERON:0007221 neonate stage A presumptive structure that has the potential to develop into a presomitic mesoderm. EFO:0003421 TAO:0000053 ZFA:0000053 uberon presumptive segmental plates UBERON:0007282 presumptive segmental plate A presumptive structure that has the potential to develop into a neural plate. consider merging Region of the gastrula which gives rise to the neural plate.[TAO] EFO:0003424 TAO:0000063 ZFA:0000063 prospective neuroectoderm prospective vegetal ectoderm uberon UBERON:0007284 presumptive neural plate A presumptive structure that has the potential to develop into a paraxial mesoderm. EFO:0003443 TAO:0000591 XAO:0004134 ZFA:0000591 future paraxial mesoderm uberon UBERON:0007285 presumptive paraxial mesoderm The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. this grouping class exists primarily to align with GO - see GO:0008544. BSA:0000073 BTO:0000313 FBbt:00004993 HAO:0000298 TADS:0000109 WBbt:0005733 epidermis epidermis (sensu Metazoa) outer epidermal layer outer epithelial layer uberon hypoderm hypodermis UBERON:0007376 outer epithelium Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. Le Guellec et al, 2004.[TAO] relationship loss: develops_from collagenous dermal stroma (TAO:0001186)[TAO] connective tissue in the skin is usually diffuse and irregular, although in some species collagen bundles are arranged in a distinct ordered layer in the dermis AAO:0010600 TAO:0001182 ZFA:0001182 dermal deep region uberon UBERON:0007377 stratum compactum Outermost layer of cells surrounding the embryo. Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO] relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO] Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm. EFO:0003425 TAO:0000086 ZFA:0000086 EVL enveloping layer uberon UBERON:0007383 enveloping layer of ectoderm An epithelial tube open at both ends that allows fluid flow. AEO_RETIRED:0000116 RETIRED_EHDAA2:0003116 uberon UBERON:0007500 epithelial tube open at both ends A closed epithelium with a lumen. EHDAA2:0003119 AEO:0000119 EHDAA2:0003119 uberon UBERON:0007503 epithelial vesicle Mesenchyme with little extracellular matrix. EHDAA2:0003146 AEO:0000146 EHDAA2:0003146 uberon UBERON:0007524 dense mesenchyme tissue Mesenchymal cells that are migrating. this class will be an important part of the NC reorganization EHDAA2:0003152 AEO:0000152 EHDAA2:0003152 uberon UBERON:0007530 migrating mesenchyme population A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. BTO:0001338 CALOHA:TS-0998 FMA:66762 synovium stratum synoviale synovial layer synovial membrane uberon synovial tissue UBERON:0007616 layer of synovial tissue An anatomical cavity that surrounded_by a synovial joint. FMA:11356 articular cavity (synovial joint) cavitas articularis (junctura synovialis) cavity of synovial joint uberon joint cavity synovial cavity UBERON:0007617 synovial cavity of joint Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. field AEO:0000170 EFO:0001649 EHDAA2:0003170 FBbt:00005426 developmental field uberon future organ organ field UBERON:0007688 anlage Any fluid produced by a serous gland. the FMA def is Transudate contained in a serous sac FMA:20932 serous gland fluid uberon UBERON:0007794 serous fluid Anatomical system that consists of all blood and lymph vessels. consider merging with vasculature The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system BTO:0001085 CALOHA:TS-2053 EHDAA2:0004520 EMAPA:35905 MA:0002718 UMLS:C0489903 uberon Gefaesssystem@ge UBERON:0007798 vascular system The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. CALOHA:TS-2356 EV:0100009 FMA:280881 MA:0000006 UMLS:C0460004 WikipediaCategory:Head_and_neck galen:HeadAndNeck uberon cephalic area cephalic part of animal cephalic region head and neck head or neck UBERON:0007811 craniocervical region Sum total of mesenchyme in the embryo. consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm) UBERON:0003313 EHDAA2:0001113 EHDAA:177 EMAPA:16097 uberon UBERON:0009142 entire embryonic mesenchyme FMA:25054 region of trunk trunk subdivision uberon UBERON:0009569 subdivision of trunk EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon trunk paraxial mesenchyme UBERON:0009618 trunk paraxial mesoderm The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. acinar acinus FMA:55588 uberon acini UBERON:0009842 glandular acinus EFO:0003704 TAO:0005041 ZFA:0005041 ALPM uberon UBERON:0009881 anterior lateral plate mesoderm An anatomical structure that has more than one cell as a part. CARO:0010000 FBbt:00100313 multicellular structure uberon UBERON:0010000 multicellular anatomical structure Mesenchyme that has the potential to develop into a dermis. check development EHDAA2:0000598 uberon UBERON:0010083 future dermis An anatomical structure that has some part that develops from the neural crest. Grouping term for query purposes uberon UBERON:0010314 structure with developmental contribution from neural crest uberon UBERON:0010316 germ layer / neural crest Epithelium composed of cells that develops from the ectoderm[FMA,modified]. FMA:69064 ectoderm-derived epithelium uberon UBERON:0010371 ecto-epithelium Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 VSAO:0000042 skeletal subdivision uberon subdivision of skeleton (in vivo) UBERON:0010912 subdivision of skeleton Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. FMA:7491 solid joint uberon UBERON:0011134 nonsynovial joint Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. FMA:7483 uberon UBERON:0011137 axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints. axial skeletal system FMA:302077 uberon UBERON:0011138 post-cranial axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton A subdivision of an anatomical system. FBbt:00007330 FMA:67509 uberon UBERON:0011216 organ system subdivision compare with 'stratum basale of epidermis'. This class is the source for many adult structures - see WP2062. See also: 'enveloping layer of ectoderm' EHDAA2:0001845 uberon basal cell layer of skin outer epithelium of body UBERON:0011272 embryonic skin basal layer Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). consider obsoleting, coordinate with VSAO VSAO:0000006 XAO:0004021 uberon UBERON:0011585 cell condensation A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem axial subdivision of organism uberon body segment main body segment UBERON:0011676 subdivision of organism along main body axis A cardiovascular system that is part of a conceptus. EHDAA2:0000216 FMA:305965 conceptus cardiovascular system uberon embryonic circulatory system fetal circulatory system UBERON:0011695 embryonic cardiovascular system Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. FMA:20107 uberon UBERON:0011821 irregular connective tissue Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT] FMA:20109 UMLS:C0738366 irregular dense connective tissue typus irregularis (textus connectivus collagenosus compactus) uberon UBERON:0011822 dense irregular connective tissue Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid. Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT] AAO:0000121 UMLS:C1511770 uberon UBERON:0011823 dense connective tissue Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. FMA:19783 UMLS:C1253917 textus connectivus collagenosus laxus textus connectivus laxus uberon UBERON:0011825 loose connective tissue An acinus that is part of a exocrine gland. exocrine gland acinus uberon UBERON:0011858 acinus of exocrine gland the FMA class specifically refers to ureter FMA:63212 MESH:D024022 NIF_Subcellular:sao7547390221 uberon UBERON:0011860 collection of collagen fibrils The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining. coelomic EHDAA2:0004731 enterocoelom haemocoelom schizocoelom uberon coelem coelomic cavity UBERON:0011997 coelom Epithelium that derives from the mesoderm. [Automatically generated definition]. FMA:86452 mesoderm-derived epithelium mesoepithelium uberon UBERON:0012275 meso-epithelium The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. FMA:86279 acinus of serous gland uberon UBERON:0013232 serous acinus The space that surrounds an organism. external to organism outside of body uberon UBERON:0013514 space surrounding organism uberon UBERON:0013522 subdivision of tube 2 2 An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. FMA:9338 foramen space uberon UBERON:0013686 anatomical conduit space A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. uberon UBERON:0013701 main body axis The region of the organism associated with the visceral organs. Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]. AEO:0000103 BTO:0001489 EMAPA:36031 FMA:231424 uberon body whole body UBERON:0013702 body proper A organ component layer that is part of a integumental system. layer of skin skin layer uberon UBERON:0013754 integumentary system layer Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. EHDAA2:0002013 FMA:77169 skeleton of thorax thoracic part of axial skeleton thoracic skeleton uberon UBERON:0014477 thoracic skeleton A portion of tissue that will develop into vasculature. EFO:0003708 TAO:0005076 ZFA:0005076 uberon UBERON:0014903 primordial vasculature Any structure that is placed on one side of the left-right axis of a bilaterian. This class is primarily to implement taxon constraints. It may be removed in the future. uberon UBERON:0015212 lateral structure A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. heart SPD:0000130 cardiac pump heart or heart like organ circulatory vessel uberon cardiac structure UBERON:0015228 circulatory organ MA:0002449 heart/pericardium uberon UBERON:0015410 heart plus pericardium Primordium that develops into the central nervous system UBERON:3000469 future CNS presumptive central nervous system uberon UBERON:0016879 future central nervous system Primordium that develops into the nervous system UBERON:3000477 AAO:0000477 presumptive nervous system uberon UBERON:0016880 future nervous system The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. AEO:0000195 EHDAA2:0000003 EMAPA:16042 extra-embryonic component extraembryonic component uberon UBERON:0016887 entire extraembryonic component An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. AEO:0000132 uberon UBERON:0016888 transitional anatomical structure A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. AEO:0001016 uberon UBERON:0017650 developing mesenchymal structure A mammalian developmental stage that covers the period from birth until weaning. suckling stage uberon UBERON:0018685 nursing stage Nursing stage that follows the neonate stage in mammals and ends at weaning. uberon UBERON:0034920 infant stage An multicellular anatomical structure that has subparts of multiple organs as a part. CARO:0020001 uberon anatomical cluster UBERON:0034921 multi organ part structure A cluster of cells, largely surrounded by a morphological boundary. CARO:0020002 FMA:62807 uberon UBERON:0034922 cell cluster A collection of anatomical structures that are alike in terms of their morphology or developmental origin. resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected uberon UBERON:0034925 anatomical collection FMA:55268 organ sector organ zonal region organ zone uberon organ region with floating fiat boundary UBERON:0034944 zone of organ uberon duct epithelium ductal epithelium UBERON:0034969 epithelial layer of duct The primordial mouth region of the developing head. FMA:293105 primitive mouth primordial mouth uberon UBERON:0035804 future mouth Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon amphibian_anatomy_curators uberon/phenoscape-anatomy external integument structure time unit A unit which is a standard measure of the dimension in which events occur in sequence. time unit A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine. vaccine a medical intervention that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intent to invoke an adaptive immune response. vaccination GAZ GAZ:00000464 Europe Part of the landmass of Eurasia, with the western portion of the latter occupied by Europe, lying east of the Suez Canal, east of the Ural Mountains, and south of the Caucasus Mountains and the Caspian and Black Seas. It is bounded on the east by the Pacific Ocean, on the south by the Indian Ocean, and on the north by the Arctic Ocean. GAZ GAZ:00000465 Asia GAZ GAZ:00002471 East Asia A sovereign island country located off the northwestern coast of mainland Europe comprising of the four constituent countries; England, Scotland, Wales and Northern Ireland. It comprises the island of Great Britain, the northeast part of the island of Ireland and many small islands. Apart from Northern Ireland the UK is surrounded by the Atlantic Ocean, the North Sea, the English Channel and the Irish Sea. The largest island, Great Britain, is linked to France by the Channel Tunnel. ISO3166-1:826 ISO3166-1:GB ISO3166-1:GBR ISO3166-2:GB Britain G.B GB U.K. {abbrevation} UK United Kingdom of Great Britain and Northern Ireland GAZ GAZ:00002637 United Kingdom An island country in East Asia. Located in the Pacific Ocean, it lies to the east of China, Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea in the south. Nippon-koku GAZ GAZ:00002747 Japan A large country in Northeast Asia. China borders 14 nations (counted clockwise from south): Vietnam, Laos, Burma, India, Bhutan, Nepal, Pakistan, Afghanistan, Tajikistan, Kyrgyzstan, Kazakhstan, Russia, Mongolia and North Korea. Additionally the border between PRC and ROC is located in territorial waters. The People's Republic of China has administrative control over twenty-two provinces and considers Taiwan to be its twenty-third province. There are also five autonomous regions, each with a designated minority group; four municipalities; and two Special Administrative Regions that enjoy considerable autonomy. The People's Republic of China administers 33 province-level regions, 333 prefecture-level regions, 2,862 county-level regions, 41,636 township-level regions, and several village-level regions. People's Republic of China Zhonghua Renmin Gongheguo GAZ GAZ:00002845 China GAZ GAZ:00002846 Northeast Asia A group of islands off the northwest coast of continental Europe that include the islands of Great Britain and Ireland, and over six thousand smaller islands. There are two sovereign states located on the islands: the United Kingdom and the Republic of Ireland. The British Isles also include two dependencies of the United Kingdom: the Isle of Man and, by tradition, the Channel Islands, although the latter are not physically a part of the island group. michaelashburner 2010-05-16T10:11:46Z GAZ GAZ:00281547 British Isles example to be eventually removed example to be eventually removed metadata complete Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. metadata complete organizational term Term created to ease viewing/sort terms for development purpose, and will not be included in a release term created to ease viewing/sort terms for development purpose, and will not be included in a release PERSON:Alan Ruttenberg organizational term ready for release Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." ready for release metadata incomplete Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. metadata incomplete uncurated Nothing done yet beyond assigning a unique class ID and proposing a preferred term. uncurated pending final vetting All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. pending final vetting to be replaced with external ontology term Terms with this status should eventually replaced with a term from another ontology. Alan Ruttenberg group:OBI to be replaced with external ontology term requires discussion A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. Alan Ruttenberg group:OBI requires discussion KPMP organization participant candidate 1 participant candidate 2 participant candidate 3 filled CRF by candidate 1 filled CRF by candidate 2 filled CRF by candidate 3 European Union Drug Regulating Authorities Clinical Trials https://en.wikipedia.org/wiki/EudraCT EudraCT ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. https://clinicaltrials.gov/ Clinicaltrials.gov SDY269 study SDY269 human subject SUB112829 ## Elucidation This is used when the statement/axiom is assumed to hold true 'eternally' ## How to interpret (informal) First the "atemporal" FOL is derived from the OWL using the standard interpretation. This axiom is temporalized by embedding the axiom within a for-all-times quantified sentence. The t argument is added to all instantiation predicates and predicates that use this relation. ## Example Class: nucleus SubClassOf: part_of some cell forall t : forall n : instance_of(n,Nucleus,t) implies exists c : instance_of(c,Cell,t) part_of(n,c,t) ## Notes This interpretation is *not* the same as an at-all-times relation axiom holds for all times en Adam Goldstein Alan Ruttenberg Albert Goldfain Barry Smith Bjoern Peters Carlo Torniai Chris Mungall Chris Stoeckert Christian A. Boelling Darren Natale David Osumi-Sutherland Gwen Frishkoff Holger Stenzhorn James A. Overton James Malone Jennifer Fostel Jie Zheng Jonathan Rees Larisa Soldatova Lawrence Hunter Mathias Brochhausen Matt Brush Melanie Courtot Michel Dumontier Paolo Ciccarese Pat Hayes Philippe Rocca-Serra Randy Dipert Ron Rudnicki Satya Sahoo Sivaram Arabandi Werner Ceusters William Duncan William Hogan Yongqun (Oliver) He http://creativecommons.org/licenses/by/4.0/ An information artifact is, loosely, a dependent continuant or its bearer that is created as the result of one or more intentional processes. Examples: uniprot, the english language, the contents of this document or a printout of it, the temperature measurements from a weather balloon. For more information, see the project home page at https://github.com/information-artifact-ontology/IAO IDs allocated to related efforts: PNO: IAO_0020000-IAO_0020999, D_ACTS: IAO_0021000-IAO_0021999 IDs allocated to subdomains of IAO. pno.owl: IAO_0020000-IAO_0020999, d-acts.owl: IAO_0021000-IAO_0021999 The Information Artifact Ontology (IAO) is licensed under the Creative Commons Attribution License (CC-BY) version 4.0. You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. You must give appropriate credit (by using the original ontology IRI for the whole ontology and original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. For more information see http://www.obofoundry.org/docs/Citation.html This version of the ontology is the merge of all its imports and has added axioms inferred by an OWL reasoner en Ontology for Biomedical Investigations Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester Alan Ruttenberg Allyson Lister Barry Smith Bill Bug Bjoern Peters Carlo Torniai Chris Mungall Chris Stoeckert Chris Taylor Christian Bolling Cristian Cocos Daniel Rubin Daniel Schober Dawn Field Dirk Derom Elisabetta Manduchi Eric Deutsch Frank Gibson Gilberto Fragoso Helen C. Causton Helen Parkinson Holger Stenzhorn James A. Overton James Malone Jay Greenbaum Jeffrey Grethe Jennifer Fostel Jessica Turner Jie Zheng Joe White John Westbrook Kevin Clancy Larisa Soldatova Lawrence Hunter Liju Fan Luisa Montecchi Matthew Brush Matthew Pocock Melanie Courtot Melissa Haendel Mervi Heiskanen Monnie McGee Norman Morrison Philippe Rocca-Serra Phillip Lord Pierre Grenon Richard Bruskiewich Richard Scheuermann Robert Stevens Ryan R. Brinkman Stefan Wiemann Susanna-Assunta Sansone Tanya Gray Tina Hernandez-Boussard Trish Whetzel Yongqun He 2009-07-31 The Ontology for Biomedical Investigations (OBI) is build in a collaborative, international effort and will serve as a resource for annotating biomedical investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. This ontology arose from the Functional Genomics Investigation Ontology (FuGO) and will contain both terms that are common to all biomedical investigations, including functional genomics investigations and those that are more domain specific. OWL-DL An ontology for the annotation of biomedical and functional genomics experiments. http://creativecommons.org/licenses/by/4.0/ Ontology for Biomedical Investigations Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them. 2022-01-03 One of the large, unbroken masses of land into which the Earth's surface is divided. GAZ:00190836 FTT:540 GeoNames:CONT TGN:21402 TGN:29000 CONTIN Continent {alternative name} continent {alternative name} continental region GAZ GAZ:00000013 continent geographic location A reference to a place on the Earth, by its name or by its geographical location. GAZ:00000467 geographic region {alternative name} GAZ GAZ:00000448 geographic location The convention used in gaz.obo is that the Europe-Asia boundary follows the watershed of the Ural Mountains from near Kara, Russia on the Kara Sea to the source of the Ural River, then follows that river to the Caspian Sea. The border then follows the watershed of the Caucasus Mountains from the Caspian Sea to the Black Sea. GAZ GAZ:00000460 Eurasia A federal constitutional republic comprising fifty states and a federal district. The country is situated mostly in central North America, where its forty-eight contiguous states and Washington, DC, the capital district, lie between the Pacific and Atlantic Oceans, bordered by Canada to the north and Mexico to the south. The State of Alaska is in the northwest of the continent, with Canada to its east and Russia to the west across the Bering Strait, and the State of Hawaii is in the mid-Pacific. The United States also possesses several territories, or insular areas, that are scattered around the Caribbean and Pacific. The states are divided into smaller administrative regions, called counties in most states, exceptions being Alaska (parts of the state are organized into subdivisions called boroughs; the rest of the state's territory that is not included in any borough is divided into "census areas"), and Louisiana (which is divided into county-equivalents that are called parishes). There are also independent cities which are within particular states but not part of any particular county or consolidated city-counties. Another type of organization is where the city and county are unified and function as an independent city. There are thirty-nine independent cities in Virginia and other independent cities or city-counties are San Francisco, California, Baltimore, Maryland, St. Louis, Missouri, Denver, Colorado and Carson City, Nevada. Counties can include a number of cities, towns, villages, or hamlets, or sometimes just a part of a city. Counties have varying degrees of political and legal significance, but they are always administrative divisions of the state. Counties in many states are further subdivided into townships, which, by definition, are administrative divisions of a county. In some states, such as Michigan, a township can file a charter with the state government, making itself into a "charter township", which is a type of mixed municipal and township status (giving the township some of the rights of a city without all of the responsibilities), much in the way a metropolitan municipality is a mixed municipality and county. ISO3166-1:840 ISO3166-1:US ISO3166-1:USA ISO3166-2:US U.S.A USA GAZ GAZ:00002459 United States of America Eric Joseph Josh Hanna Mathias Brochhausen William Hogan https://creativecommons.org/licenses/by/3.0/ An ontology of drugs. DrOn contains content developed by the National Library of Medicine in RxNorm. In creating DrOn, we have used RxNorm content only with SAB = RXNORM. When citing DrOn, use the permanent URL of the ontology: http://purl.obolibrary.org/obo/dron.owl. When referencing a specific component of the DrOn, such as a class, object property, annotation property, or individual, use the Uniform Resource Identifier (URI) of that component. http://orcid.org/0000-0002-4366-3088 http://orcid.org/0000-0002-6601-2165 http://orcid.org/0000-0002-8343-612X http://orcid.org/0000-0003-1604-1512 https://orcid.org/0000-0002-6962-2807 ENVO is an ontology which represents knowledge about environments,environmental processes, ecosystems, habitats, and related entities. It interoperates with other ontologies in the OBO Foundry and Library. New terms or revisions can be requested at https://github.com/EnvironmentOntology/envo/issues/ Please see www.environmentontology.org for more information and citations. Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/envo/modules/chemical_concentration.owl>) VersionIRI(<null>))) [Axioms: 186 Logical Axioms: 30] Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/envo/modules/entity_attribute.owl>) VersionIRI(<null>))) [Axioms: 114 Logical Axioms: 19] Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/envo/modules/entity_attribute_location.owl>) VersionIRI(<null>))) [Axioms: 132 Logical Axioms: 23] Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/envo/modules/entity_quality_location.owl>) VersionIRI(<null>))) [Axioms: 40 Logical Axioms: 6] Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/envo/modules/process_attribute.owl>) VersionIRI(<null>))) [Axioms: 21 Logical Axioms: 2] Product version Darrell R. Abernethy Elizabeth Blair Izabela Birsanescu Keith Burkhart Luca Toldo Mathias Brochhausen Sydni Joubran "Asiyah" Yu Lin Abra Guo Barry Smith Bingjian Yang David Ameriguian Desikan Jagannathan Edison Ong Jiangan Xie Kelly Yang Kevin Mo Ling Wan Liwei Wang Meiu Wong Noemi Garg Qingping Liu Rebecca Racz Shelley Zhang Sirarat Sarntivijai Sydni Joubran Yongqun "Oliver" He (YH) Zuoshuang "Allen" Xiang 2019-2-21 The Ontology of Adverse Eventsy (OAE) is a biomedical ontology in the domain of adverse events. OAE aims to standardize adverse event annotation, integrate various adverse event data, and support computer-assisted reasoning. OAE is a community-based ontology. Its development follows the OBO Foundry principles. Vaccine adverse events have been used as an initial testing use case. OAE also studies adverse events associated with the administration of drug and nutritional products, the operation of surgeries, and the usage of medical devices, etc. OWL-DL An ontology for the annotation of the adverse event domain. OAE: Ontology of Adverse Events Vision Release; 1.2.19 Alice Nzinga Chris Stoeckert Jan-Eric Litton Jie Zheng Loreana Norlin Maria Anderberg Martin N. Fransson Mathias Brochhausen Mikael Eriksson Roxana Merino-Martinez Sanela Kjellqvist William R. Hogan The Ontology for Biobanking (OBIB) is an ontology for the annotation and modeling of the activities, contents, and administration of a biobank. Biobanks are facilities that store specimens, such as bodily fluids and tissues, typically along with specimen annotation and clinical data. OBIB is based on a subset of the Ontology for Biomedical Investigation (OBI), has the Basic Formal Ontology (BFO) as its upper ontology, and is developed following OBO Foundry principles. The first version of OBIB resulted from the merging of two existing biobank-related ontologies, OMIABIS and biobank ontology. MIABIS_v2_accepted and UPenn Biobank ontology Ontology for BIoBanking (OBIB) 2021-11-12 development version Alan Ruttenberg Albert Goldfain Anand Kumar Barry Smith Bill Hogan Brian Aevermann Cornelius Rosse Daniel Merico Jie Zheng Lindsay Cowell Richard Scheuermann Sivaram Arabandi Werner Ceusters 2009-08-07 The Ontology for General Medical Science (OGMS) is an ontology of entities involved in a clinical encounter. OGMS includes very general terms that are used across medical disciplines, including: 'disease', 'disorder', 'disease course', 'diagnosis', 'patient', and 'healthcare provider'. OGMS uses the Basic Formal Ontology (BFO) as an upper-level ontology. The scope of OGMS is restricted to humans, but many terms can be applied to a variety of organisms. OGMS provides a formal theory of disease that can be further elaborated by specific disease ontologies. This theory is implemented using OWL-DL and OBO Relation Ontology relations and is available in OWL and OBO formats. OGMS is based on the papers Toward an Ontological Treatment of Disease and Diagnosis and On Carcinomas and Other Pathological Entities. The ontology attempts to address some of the issues raised at the Workshop on Ontology of Diseases (Dallas, TX) and the Signs, Symptoms, and Findings Workshop(Milan, Italy). OGMS was formerly called the clinical phenotype ontology. Terms from OGMS hang from the Basic Formal Ontology. Ontology for General Medical Science http://creativecommons.org/licenses/by/4.0/ The Ontology for General Medical Science (OGMS) is based on the papers Toward an Ontological Treatment of Disease and Diagnosis and On Carcinomas and Other Pathological Entities. The ontology attempts to address some of the issues raised at the Workshop on Ontology of Diseases (Dallas, TX). OGMS was formerly called the clinical phenotype ontology. Terms from OGMS hang from the Basic Formal Ontology. The latest version of OGMS is available at http://purl.obolibrary.org/obo/ogms.owl The OGMS developer site is https://github.com/OGMS/ogms If you are interested in participating in the development of OGMS, please send email to baeverma 2021-08-19 Daniel Welch Amanda Hicks Mathias Brochhausen Shariq Tariq Swetha Garimalla William Hogan This ontology grew out of efforts to represent the reality underlying the demographic information required by the US federal government's "meaningful use" criteria for electronic medical records and a presentation by Dr. William Hogan at the Electronic Health Record of the Future conference in Buffalo, NY http://ontology.buffalo.edu/EHR/Demographics_Hogan_Buffalo_2010_09_22.ppt The Ontology of Medically Related Social Entities 2017-06-08