OPMI: Ontology of Precision Medicine and Investigation
type: Ontology
Contributor: Becky Steck
Contributor: Christopher Park
Contributor: John F. O’Toole
Contributor: Matthias Kretzler
Contributor: Sean Mooney
creator: Anthony Huffman
creator: Asiyah Yu Lin
creator: Fred Dowd
creator: Hong Yu
creator: Jennifer Schaub
creator: Jie Zheng
creator: Long Tran
creator: Qingliang Leon Li
creator: Suyuan Peng
creator: Yongqun "Oliver" He (YH)
date: 3-15-2024
description: OPMI is a biomedical ontology in the area of precision medicine and its related investigations. It is community-driven and developed by following the OBO Foundry ontology development principles.
Format: OWL-DL
subject: OPMI subject: Precision medicine and related investigations
license: http://creativecommons.org/licenses/by/4.0/
version info: Vision Release: 1.0.166

BFO OWL specification label
type: AnnotationProperty
editor preferred label: BFO OWL specification label
definition: Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
curator note: Really of interest to developers only
sub property of: label

BFO CLIF specification label
type: AnnotationProperty
editor preferred label: BFO CLIF specification label
definition: Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
definition source: Person:Alan Ruttenberg
curator note: Really of interest to developers only
sub property of: label

editor preferred label
type: AnnotationProperty
editor preferred label: editor preferred label
editor preferred label: editor preferred term
editor preferred label: editor preferred term~editor preferred label
has curation status: ready for release
definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: editor preferred term
label: editor preferred term~editor preferred label

example of usage
type: AnnotationProperty
editor preferred label: example
editor preferred label: example of usage
has curation status: ready for release
definition: A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
definition: A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

has curation status
type: AnnotationProperty
editor preferred label: has curation status
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bill Bug
definition editor: PERSON:Melanie Courtot
definition source: OBI_0000281

definition
type: AnnotationProperty
editor preferred label: definition
editor preferred label: textual definition
has curation status: ready for release
definition: English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
has exact synonym: DEFINITION
label: textual definition

editor note
type: AnnotationProperty
editor preferred label: editor note
has curation status: ready for release
definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
definition source: GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
database_cross_reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: 1
shorthand: editor_note

definition editor
type: AnnotationProperty
editor preferred label: definition editor
editor preferred label: term editor
has curation status: ready for release
definition: Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people
definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: term editor

alternative term
type: AnnotationProperty
editor preferred label: alternative term
has curation status: pending final vetting
definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

definition source
type: AnnotationProperty
editor preferred label: definition source
has curation status: ready for release
definition: Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

has obsolescence reason
type: AnnotationProperty
editor preferred label: has obsolescence reason
definition: Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification.
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Melanie Courtot

curator note
type: AnnotationProperty
editor preferred label: curator note
has curation status: ready for release
definition: An administrative note of use for a curator but of no use for a user
definition editor: PERSON:Alan Ruttenberg
database_cross_reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: 1
shorthand: curator_notes
label: curator notes

term tracker item
type: AnnotationProperty
editor preferred label: term tracker item
example of usage: the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
has curation status: pending final vetting
definition: An IRI or similar locator for a request or discussion of an ontology term.
definition editor: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
definition source: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
comment: The 'tracker item' can associate a tracker with a specific ontology term.

ontology term requester
type: AnnotationProperty
editor preferred label: ontology term requester
has curation status: pending final vetting
definition: The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition.
definition editor: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
definition source: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
comment: The 'term requester' can credit the person, organization or project who request the ontology term.

imported from
type: AnnotationProperty
editor preferred label: imported from
has curation status: pending final vetting
definition: For external terms/classes, the ontology from which the term was imported
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

expand expression to
type: AnnotationProperty

expand assertion to
type: AnnotationProperty

OBO foundry unique label
type: AnnotationProperty
editor preferred label: OBO foundry unique label
has curation status: pending final vetting
definition: An alternative name for a class or property which is unique across the OBO Foundry.
editor note: The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools .
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
definition editor: PERSON:Chris Mungall
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBO Foundry <http://obofoundry.org/>

elucidation
type: AnnotationProperty
editor preferred label: elucidation
definition editor: person:Alan Ruttenberg
definition source: Person:Barry Smith
elucidation: Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms

has associated axiom(nl)
type: AnnotationProperty
editor preferred label: has associated axiom(nl)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom associated with a term expressed using natural language

has associated axiom(fol)
type: AnnotationProperty
editor preferred label: has associated axiom(fol)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom expressed in first order logic using CLIF syntax

term_mapping_to_UMLS
type: AnnotationProperty
term_mapping_to_UMLS: C3829466
term_mapping_to_NCIT: NCIT_C106180
sub property of: seeAlso

term_mapping_to_NCIT
type: AnnotationProperty
sub property of: seeAlso

Has_NICHD_Parent
type: AnnotationProperty
definition: A property created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source.
code: A11
Semantic_Type: Conceptual Entity
Preferred_Name: Has_NICHD_Parent
has exact synonym: Has_NICHD_Parent

code
type: AnnotationProperty
read only: true
code: NHC0
Preferred_Name: code
has exact synonym: code

Semantic_Type
type: AnnotationProperty
definition: The semantic type describes the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
code: P106
Semantic_Type: Conceptual Entity
Display_Name: Semantic Type
Preferred_Name: Semantic_Type
DesignNote: In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS.
has exact synonym: Semantic_Type

Display_Name
type: AnnotationProperty
definition: Provides an alternative Preferred Name for use in some NCI systems.
code: P107
Semantic_Type: Conceptual Entity
Display_Name: Display Name
Preferred_Name: Display_Name
has exact synonym: Display Name
has exact synonym: Display_Name

Preferred_Name
type: AnnotationProperty
definition: The word or phrase that NCI uses by preference to refer to the concept.
code: P108
Semantic_Type: Conceptual Entity
Display_Name: Preferred Name
Preferred_Name: Preferred_Name
has exact synonym: Preferred Name
has exact synonym: Preferred Term
has exact synonym: Preferred_Name

UMLS_CUI
type: AnnotationProperty
definition: Concept Unique Identifiers, or CUIs, are concept numbers assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
code: P207
Semantic_Type: Conceptual Entity
Display_Name: UMLS CUI
Preferred_Name: UMLS_CUI
has exact synonym: UMLS_CUI

NCI_META_CUI
type: AnnotationProperty
definition: Contains a Concept Unique Identifier for those concepts that appear in NCI Metathesaurus but not in the NLM UMLS.
code: P208
Semantic_Type: Conceptual Entity
Display_Name: NCI Metathesaurus CUI
Preferred_Name: NCI_META_CUI
has exact synonym: NCI_META_CUI

Concept_Status
type: AnnotationProperty
definition: An NCI Thesaurus property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used.
code: P310
Semantic_Type: Conceptual Entity
Display_Name: Concept Status
Preferred_Name: Concept_Status
has exact synonym: Concept_Status

Contributing_Source
type: AnnotationProperty
definition: This property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake.
code: P322
Semantic_Type: Conceptual Entity
Display_Name: Contributing Source
Preferred_Name: Contributing_Source
has exact synonym: Contributing_Source

ALT_DEFINITION
type: AnnotationProperty
definition: English language definitions of what a source other than NCI means by the concept. These are limited to 1024 characters. They include information about the definition's source in a form that can easily be interpreted by software.
code: P325
Semantic_Type: Conceptual Entity
Display_Name: [source] Definition
Preferred_Name: ALT_DEFINITION
has exact synonym: ALT_DEFINITION

Legacy_Concept_Name
type: AnnotationProperty
read only: true
definition: A retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding.
code: P366
Semantic_Type: Conceptual Entity
Preferred_Name: Legacy Concept Name
has exact synonym: Legacy Concept Name

NICHD_Hierarchy_Term
type: AnnotationProperty
code: P371
Semantic_Type: Conceptual Entity
Preferred_Name: NICHD_Hierarchy_Term
Contributing_Source: NICHD
has exact synonym: NICHD_Hierarchy_Term

DesignNote
type: AnnotationProperty
definition: Design notes are notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
code: P98
Semantic_Type: Conceptual Entity
Display_Name: DesignNote
Preferred_Name: DesignNote
has exact synonym: DesignNote

has_MedDRA_id
type: AnnotationProperty

ISA alternative term
type: AnnotationProperty
editor preferred label: ISA alternative term
has curation status: ready for release
definition: An alternative term used by the ISA tools project (http://isa-tools.org).
editor note: Requested by Alejandra Gonzalez-Beltran https://sourceforge.net/tracker/?func=detail&aid=3603413&group_id=177891&atid=886178
definition editor: Person: Alejandra Gonzalez-Beltran
definition editor: Person: Philippe Rocca-Serra
definition source: ISA tools project (http://isa-tools.org)
sub property of: alternative term

NIAID GSCID-BRC alternative term
type: AnnotationProperty
editor preferred label: NIAID GSCID-BRC alternative term
has curation status: ready for release
definition: An alternative term used by the National Institute of Allergy and Infectious Diseases (NIAID) Genomic Sequencing Centers for Infectious Diseases (GSCID) and Bioinformatics Resource Centers (BRC).
definition editor: PERSON: Chris Stoeckert, Jie Zheng
definition source: NIAID GSCID-BRC metadata working group
sub property of: alternative term

IEDB alternative term
type: AnnotationProperty
editor preferred label: IEDB alternative term
has curation status: ready for release
definition: An alternative term used by the IEDB.
definition editor: PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters
definition source: IEDB
sub property of: alternative term

term mapping to NCIT ID
type: AnnotationProperty
definition: A subproperty of seeAlso that represents a NCIT identifier mapped to the specified term
definition editor: Oliver He
sub property of: seeAlso

term mapping to UMLS CUI
type: AnnotationProperty
definition: A subproperty of seeAlso that represents a UMLS CUI identifier mapped to the specified term
definition editor: Oliver He
sub property of: seeAlso

NCIT code
type: AnnotationProperty
definition: An annotation property that refers to a code defined by NCIT

alternative term in Chinese
type: AnnotationProperty
sub property of: alternative term

temporal interpretation
type: AnnotationProperty
definition: An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.
sub property of: logical macro assertion on an object property

never in taxon
type: AnnotationProperty
example of usage: tooth SubClassOf 'never in taxon' value 'Aves'
definition: x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
expand assertion to: ?X DisjointWith RO_0002162 some ?Y
sub property of: taxonomic class assertion

taxonomic class assertion
type: AnnotationProperty
definition: An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon.
sub property of: logical macro assertion on a class

dubious_for_taxon
type: AnnotationProperty
definition: S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
database_cross_reference: RO:0002174
has_obo_namespace: uberon
id: dubious_for_taxon
is class level: 1
is metadata tag: 1
shorthand: dubious_for_taxon
comment: this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost

present_in_taxon
type: AnnotationProperty
definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
database_cross_reference: RO:0002175
has exact synonym: applicable for taxon
has_obo_namespace: uberon
id: present_in_taxon
is class level: 1
is metadata tag: 1
shorthand: present_in_taxon

logical macro assertion
type: AnnotationProperty
definition: An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL.

logical macro assertion on a class
type: AnnotationProperty
definition: A logical macro assertion whose domain is an IRI for a class
editor note: The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL
sub property of: logical macro assertion

logical macro assertion on a property
type: AnnotationProperty
definition: A logical macro assertion whose domain is an IRI for a property
sub property of: logical macro assertion

logical macro assertion on an object property
type: AnnotationProperty
sub property of: logical macro assertion on a property

logical macro assertion on an annotation property
type: AnnotationProperty
sub property of: logical macro assertion on a property

is direct form of
type: AnnotationProperty
definition: relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y
logical macro assertion on an annotation property: If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'
creator: Chris Mungall
sub property of: logical macro assertion on an object property

external_definition
type: AnnotationProperty
definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: UBPROP:0000001
has_obo_namespace: uberon
id: external_definition
is metadata tag: 1
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

axiom_lost_from_external_ontology
type: AnnotationProperty
definition: A textual description of an axiom loss in this ontology compared to an external ontology.
database_cross_reference: UBPROP:0000002
has_obo_namespace: uberon
id: axiom_lost_from_external_ontology
is metadata tag: 1
shorthand: axiom_lost_from_external_ontology
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

homology_notes
type: AnnotationProperty
definition: Notes on the homology status of this class.
database_cross_reference: UBPROP:0000003
has_obo_namespace: uberon
id: homology_notes
is metadata tag: 1
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

has_relational_adjective
type: AnnotationProperty
curator note: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
database_cross_reference: UBPROP:0000007
has_obo_namespace: uberon
id: has_relational_adjective
is metadata tag: 1
shorthand: has_relational_adjective

taxon_notes
type: AnnotationProperty
definition: Notes on the how instances of this class vary across species.
database_cross_reference: UBPROP:0000008
has_obo_namespace: uberon
id: taxon_notes
is metadata tag: 1
shorthand: taxon_notes

structure_notes
type: AnnotationProperty
definition: Notes on the structure, composition or histology of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000010
has_obo_namespace: uberon
id: structure_notes
is metadata tag: 1
shorthand: structure_notes

development_notes
type: AnnotationProperty
definition: Notes on the ontogenic development of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000011
has_obo_namespace: uberon
id: development_notes
is metadata tag: 1
shorthand: development_notes

external_ontology_notes
type: AnnotationProperty
definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000012
has_obo_namespace: uberon
id: external_ontology_notes
is metadata tag: 1
shorthand: external_ontology_notes

terminology_notes
type: AnnotationProperty
definition: Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000013
has_obo_namespace: uberon
id: terminology_notes
is metadata tag: 1
shorthand: terminology_notes

has_rank
type: AnnotationProperty
definition: A metadata relation between a class and its taxonomic rank (eg species, family)
has_obo_namespace: ncbi_taxonomy

Contributor
type: AnnotationProperty
description: Examples of a Contributor include a person, an organisation, or a service. Typically, the name of a Contributor should be used to indicate the entity.
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: 1
shorthand: dc-contributor
comment: An entity responsible for making contributions to the content of the resource.
label: contributor

Creator
type: AnnotationProperty
description: Examples of a Creator include a person, an organisation, or a service. Typically, the name of a Creator should be used to indicate the entity.
comment: An entity primarily responsible for making the content of the resource.

Date
type: AnnotationProperty
description: Typically, Date will be associated with the creation or availability of the resource. Recommended best practice for encoding the date value is defined in a profile of ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format.
comment: A date associated with an event in the life cycle of the resource.

Description
type: AnnotationProperty
description: Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content.
comment: An account of the content of the resource.

Format
type: AnnotationProperty
description: Typically, Format may include the media-type or dimensions of the resource. Format may be used to determine the software, hardware or other equipment needed to display or operate the resource. Examples of dimensions include size and duration. Recommended best practice is to select a value from a controlled vocabulary (for example, the list of Internet Media Types [MIME] defining computer media formats).
comment: The physical or digital manifestation of the resource.

Source
type: AnnotationProperty
description: The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system.
comment: A reference to a resource from which the present resource is derived.

Subject and Keywords
type: AnnotationProperty
description: Typically, a Subject will be expressed as keywords, key phrases or classification codes that describe a topic of the resource. Recommended best practice is to select a value from a controlled vocabulary or formal classification scheme.
comment: The topic of the content of the resource.

license
type: AnnotationProperty
definition editor: Mark Miller
date: 2018-05-11T13:47:29Z

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has exact synonym
type: AnnotationProperty
definition: Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
has exact synonym: FULL_SYN
has exact synonym: Synonym with Source Data
label: has_exact_synonym

has_narrow_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

in subset
type: AnnotationProperty
definition: Used to associate the concept defining a particular terminology subset with concepts that belong to this subset.
has exact synonym: Concept_In_Subset
label: in_subset

shorthand
type: AnnotationProperty

label
type: AnnotationProperty
editor preferred label: label

depicted_by
type: AnnotationProperty
has_obo_namespace: uberon
id: foaf-depicted_by
is metadata tag: 1
shorthand: foaf-depicted_by

part of
type: ObjectProperty
sub property of: overlaps
inverse of: has part
type: TransitiveProperty
editor preferred label: is part of
example of usage: my brain is part of my body (continuant parthood, two material entities)
example of usage: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
example of usage: this day is part of this year (occurrent parthood)
definition: a core relation that holds between a part and its whole
editor note: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
alternative term: part_of
imported from: envo.owl
imported from: go.owl
imported from: iao.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
database_cross_reference: BFO:0000050
has_obo_namespace: uberon
id: part_of
shorthand: part_of

has part
type: ObjectProperty
equivalent property:
  inverse of: part of
sub property of: overlaps
sub property of: determined by
type: TransitiveProperty
editor preferred label: has part
example of usage: my body has part my brain (continuant parthood, two material entities)
example of usage: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
example of usage: this year has part this day (occurrent parthood)
definition: a core relation that holds between a whole and its part
editor note: Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
alternative term: has_part
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
database_cross_reference: BFO:0000051
has_obo_namespace: uberon
id: has_part
shorthand: has_part

is_bearer_of
type: ObjectProperty
sub property of: topObjectProperty
alternative term: bearer of
alternative term: bearer_of
imported from: dron.owl
imported from: http://purl.obolibrary.org/obo/omrse.owl
label: is bearer of

realized in
type: ObjectProperty
sub property of: topObjectProperty
inverse of: realizes
domain: realizable entity
range: process
editor preferred label: realized in
example of usage: this disease is realized in this disease course
example of usage: this fragility is realized in this shattering
example of usage: this investigator role is realized in this investigation
alternative term: is realized by
alternative term: realized_in
imported from: dron.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl
imported from: http://purl.obolibrary.org/obo/ro.owl
elucidation: [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

realizes
type: ObjectProperty
domain: process
range: realizable entity
editor preferred label: realizes
example of usage: this disease course realizes this disease
example of usage: this investigation realizes this investigator role
example of usage: this shattering realizes this fragility
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
elucidation: to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

preceded_by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: starts during
property chain axiom: happens during
editor preferred label: preceded by
definition: X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)
definition: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
editor note: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
alternative term: is preceded by
alternative term: preceded_by
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
Source: http://www.obofoundry.org/ro/#OBO_REL:preceded_by
database_cross_reference: BFO:0000062
has exact synonym: is preceded by
has exact synonym: takes place after
has_obo_namespace: uberon
id: preceded_by
in subset: ro-eco
shorthand: preceded_by
label: preceded by

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: happens during
editor preferred label: precedes
definition: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: BFO:0000063
has_obo_namespace: uberon
id: precedes
in subset: ro-eco
shorthand: precedes

occurs in
type: ObjectProperty
inverse of: contains process
domain: occurrent
range: independent continuant
property chain axiom: part of
editor preferred label: occurs in
definition: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
alternative term: occurs_in
alternative term: unfolds in
alternative term: unfolds_in
imported from: go.owl
imported from: oae.owl
imported from: ro.owl
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant

contains process
type: ObjectProperty
editor preferred label: site of
definition: [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant

has temporal occupant
type: ObjectProperty
range: occurrent
BFO OWL specification label: span-of
BFO CLIF specification label: spanOf
imported from: obib.owl
imported from: bfo.owl
elucidation: [copied from inverse property 'occupies temporal region'] p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001])

anterior_to
type: ObjectProperty
type: TransitiveProperty
definition: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer
imported from: oae.owl
imported from: uberon.owl
created by: cjm
creation date: 2009-07-31T02:15:46Z
database_cross_reference: BSPO:0000096
has_obo_namespace: uberon
id: anterior_to
shorthand: anterior_to

dorsal_to
type: ObjectProperty
inverse of: ventral_to
type: TransitiveProperty
definition: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000098
has_obo_namespace: uberon
id: dorsal_to
shorthand: dorsal_to

ventral_to
type: ObjectProperty
type: TransitiveProperty
definition: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000102
has_obo_namespace: uberon
id: ventral_to
shorthand: ventral_to

deep_to
type: ObjectProperty
type: TransitiveProperty
definition: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000107
has_obo_namespace: uberon
id: deep_to
shorthand: deep_to

superficial_to
type: ObjectProperty
definition: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000108
has_obo_namespace: uberon
id: superficial_to
shorthand: superficial_to

in_proximal_side_of
type: ObjectProperty
sub property of: part of
inverse of: in_distal_side_of
definition: X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000124
has_obo_namespace: uberon
id: in_proximal_side_of
shorthand: in_proximal_side_of

in_distal_side_of
type: ObjectProperty
sub property of: part of
definition: X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000125
has_obo_namespace: uberon
id: in_distal_side_of
shorthand: in_distal_side_of

in_lateral_side_of
type: ObjectProperty
sub property of: part of
property disjoint with: in_central_side_of
definition: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000126
has_obo_namespace: uberon
id: in_lateral_side_of
shorthand: in_lateral_side_of

proximalmost_part_of
type: ObjectProperty
sub property of: in_proximal_side_of
definition: X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0001106
has_obo_namespace: uberon
id: proximalmost_part_of
shorthand: proximalmost_part_of

has measurement unit label
type: ObjectProperty
sub property of: has part
type: FunctionalProperty
range: measurement unit label
imported from: iao.owl

is about
type: ObjectProperty
domain: information content entity
example of usage: This document is about information artifacts and their representations
has curation status: pending final vetting
definition: A (currently) primitive relation that relates an information artifact to an entity.
definition: is_about is a (currently) primitive relation that relates an information artifact to an entity.
editor note: 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. We will try to build it back up by elaborating the various subproperties that are more precisely defined. Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
definition editor: person:Alan Ruttenberg
definition source: Smith, Ceusters, Ruttenberg, 2000 years of philosophy
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl

denotes
type: ObjectProperty
sub property of: is about
inverse of: denoted by
domain: information content entity
range: entity
example of usage: A person's name denotes the person. A variable name in a computer program denotes some piece of memory. Lexically equivalent strings can denote different things, for instance "Alan" can denote different people. In each case of use, there is a case of the denotation relation obtaining, between "Alan" and the person that is being named.
definition: A primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically
definition: denotes is a primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically
editor note: 2009-11-10 Alan Ruttenberg. Old definition said the following to emphasize the generic nature of this relation. We no longer have 'specifically denotes', which would have been primitive, so make this relation primitive. g denotes r =def r is a portion of reality there is some c that is a concretization of g every c that is a concretization of g specifically denotes r
definition editor: person:Alan Ruttenberg
definition source: Conversations with Barry Smith, Werner Ceusters, Bjoern Peters, Michel Dumontier, Melanie Courtot, James Malone, Bill Hogan
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

denoted by
type: ObjectProperty
domain: entity
range: information content entity
definition: inverse of the relation 'denotes'
definition editor: Person: Jie Zheng, Chris Stoeckert, Mike Conlon
term tracker item: https://github.com/information-artifact-ontology/IAO/issues/206
imported from: Ontology for Biomedical Investigations

is duration of
type: ObjectProperty
sub property of: is about
domain: time measurement datum
range: process
has curation status: metadata complete
definition: relates a process to a time-measurement-datum that represents the duration of the process
definition editor: Person:Alan Ruttenberg
imported from: iao.owl

has participant quality
type: ObjectProperty
example of usage: An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased.
definition: an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality.
editor note: This is a shortcut relation of the following full version: 'has participant' some (participant 'has quality' ) in: process 'has participant' some (participant 'has quality' some quality)
definition editor: Yongqun He
imported from: oae.owl

AE occurs in
type: ObjectProperty
sub property of: occurs in
definition: a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in.
definition editor: Yongqun He
alternative term: adverse event occurs in
imported from: oae.owl

adverse event preceded by
type: ObjectProperty
sub property of: preceded_by
domain: adverse event
definition: a specific 'preceded by' object property that has a domain of an adverse event.
definition editor: Yongqun He
imported from: oae.owl

provides_service_consumer_with
type: ObjectProperty
sub property of: has part
domain: service
editor preferred label: provides_service_consumer_with
example of usage: The provides_service_consumer_with relation links the service to its primary process it provides for the consumer (as opposed to secondary processual parts of a service process such as payment or documentation). For example, a 'DNA sequencing service' provides_service_consumer_with 'DNA sequencing' as the essential process performed by the provider for the client.
has curation status: metadata incomplete
definition: A relation between a service and the primary processual part of the service that is performed by the provider for the consumer.
imported from: Ontology for Biomedical Investigations

is_supported_by_data
type: ObjectProperty
domain: conclusion based on data
range: data item
editor preferred label: is_supported_by_data
example of usage: The relation between the conclusion "Gene tpbA is involved in EPS production" and the data items produced using two sets of organisms, one being a tpbA knockout, the other being tpbA wildtype tested in polysacharide production assays and analyzed using an ANOVA.
has curation status: ready for release
definition: The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process
definition editor: OBI
definition source: OBI
definition source: Philly 2011 workshop
imported from: Ontology for Biomedical Investigations

has_specified_input
type: ObjectProperty
equivalent property:
  inverse of: is_specified_input_of
sub property of: has_participant
inverse of: is_specified_input_of
domain: planned process
editor preferred label: has_specified_input
example of usage: see is_input_of example_of_usage
has curation status: ready for release
definition: A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
definition: The inverse property of is_specified_input_of
editor note: 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Larry Hunter
definition editor: PERSON: Melanie Coutot
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl

is_specified_input_of
type: ObjectProperty
sub property of: participates in
range: planned process
editor preferred label: is_specified_input_of
example of usage: some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay
has curation status: ready for release
definition: A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
definition editor: Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

has_specified_output
type: ObjectProperty
equivalent property:
  inverse of: is_specified_output_of
sub property of: has_participant
sub property of: topObjectProperty
inverse of: is_specified_output_of
domain: planned process
editor preferred label: has_specified_output
has curation status: ready for release
definition: A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
definition: The inverse property of is_specified_output_of
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Larry Hunter
definition editor: PERSON: Melanie Courtot
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl

is_specified_output_of
type: ObjectProperty
equivalent property:
  inverse of: has_specified_output
sub property of: participates in
range: planned process
editor preferred label: is_specified_output_of
has curation status: ready for release
definition: A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
definition editor: Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl

achieves_planned_objective
type: ObjectProperty
inverse of: objective_achieved_by
domain: planned process
range: objective specification
editor preferred label: achieves_planned_objective
example of usage: A cell sorting process achieves the objective specification 'material separation objective'
has curation status: metadata complete
definition: This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process.
definition editor: BP, AR, PPPB branch
definition source: PPPB branch derived
curator note: modified according to email thread from 1/23/09 in accordince with DT and PPPB branch
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

has grain
type: ObjectProperty
sub property of: has part
editor preferred label: has grain
has curation status: metadata complete
definition: the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car.
editor note: Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form
definition editor: PERSON: Alan Ruttenberg
definition source: PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349
imported from: Ontology for Biomedical Investigations

objective_achieved_by
type: ObjectProperty
domain: objective specification
range: planned process
editor preferred label: objective_achieved_by
has curation status: ready for release
definition: This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process.
definition editor: OBI
definition source: OBI
imported from: Ontology for Biomedical Investigations

has organization member
type: ObjectProperty
domain: organization
range: Class
  union of: Homo sapiens
  union of: organization
imported from: omrse.owl

has value specification
type: ObjectProperty
sub property of: has part
domain: information content entity
range: value specification
editor preferred label: has value specification
has curation status: metadata complete
definition: A relation between an information content entity and a value specification that specifies its value.
definition editor: PERSON: James A. Overton
definition source: OBI
imported from: Ontology for Biomedical Investigations

is-aggregate-of
type: ObjectProperty
has obsolescence reason: BFO relation takes precedence.
imported from: omrse.owl
comment: We anticipate BFO 2.0 including and defining this relation. When it does, we will obsolete this property and declare it equivalent to the BFO 2.0 relation.
deprecated: true

executed in
type: ObjectProperty
example of usage: A kidney biopsy protocol is executed in a kidney biopsy process.
definition: A shortcut relation that is concretized and realized in some process.
definition editor: Jie Zheng, Oliver He

has question
type: ObjectProperty
sub property of: has part
range: textual question
definition: A 'has part' object property that has the range of a textual question
definition editor: Oliver He

form generated by
type: ObjectProperty

has answer
type: ObjectProperty
definition: An object property that indicates a relation between a question and an answer
alternative term: has answer to question

has exclusion question
type: ObjectProperty
sub property of: has question
definition: An object property that represents a relation between a form and a question where the question sets up an exclusion criterion. Specifically, when the answer to the question is Yes, the candidate becomes ineligible for the participation of a study.
definition editor: Fred Dowd, Oliver He

has inclusion question
type: ObjectProperty
sub property of: has question
definition: An object property that represents a relation between a form and a question where the question sets up an inclusion criterion. Specifically, when the answer to the question is Yes, then the candidate fulfills a criterion for being eligible for participating in a study. Note that there might be other criteria that the candidate also need to meet in order to be fully eligible. Meanwhile, if the answer is No, the candidate may still be eligible depending on the other restriction.
definition editor: Fred Dowd, Oliver He

has process quality
type: ObjectProperty

has sex-specific susceptibility to
type: ObjectProperty
definition: An object property that represents a relation between a person with a biological sex and a process where the person has a specific susceptbility to a process
definition editor: Anthony Huffman, Oliver He

has increased susceptibility compared to male to
type: ObjectProperty
sub property of: has sex-specific susceptibility to
definition: An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding male population
definition editor: Anthony Huffman, Oliver He

has increased susceptibility compared to female to
type: ObjectProperty
sub property of: has sex-specific susceptibility to
example of usage: Male has increased susceptibility to death due to COVID-19 infection compared to female. Note that in this case, the male can mean one single male individual. however, the female here means the whole female population. It is reported that the ratio of deaths in COVID-19 infected males to females is 1·21:1 in high-income countries, but 2·8:1 in low-income countries (Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023692/).
definition: An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding female population
definition editor: Anthony Huffman, Oliver He

has increased sex-specific susceptibility compared to sex baseline to
type: ObjectProperty
sub property of: has sex-specific susceptibility to
definition: An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to the whole population with all sexes included
definition editor: Anthony Huffman, Oliver He

has identifier
type: ObjectProperty
example of usage: A care_site has a care_site_id (OMOP: http://ohdsi.github.io/CommonDataModel/cdm54.html#CARE_SITE)
definition: An object property that represents a relation between an entity and its corresponding identifier that is owned by the entity.
definition editor: Oliver He, Long Tran

admitted from
type: ObjectProperty
example of usage: A patient was admitted to the hospital from home or a long-term care facility.
definition: An object property that represents a relation between a patient and a site from which the patient was admitted.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

discharged to
type: ObjectProperty
example of usage: After a visit, a person was discharged to home or a long-term care site. Typically this applies only to visits that have a length of stay of a day or more.
definition: An object property that represents a relation between a patient and a site to which the patient was discharged after a visit.
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

has status content
type: ObjectProperty
domain: status
range: information content entity
example of usage: An admission diagnosis status has the content of adimission diagnosis (as an information content entity).
definition: An object property that represents a relation between a status and an information content entity where the status has its content information defined by the information content entity.
definition editor: Oliver He, Long Tran

characteristic of
type: ObjectProperty
equivalent property:
  inverse of: bearer of
sub property of: inheres in part of
sub property of: topObjectProperty
inverse of: bearer of
type: FunctionalProperty
editor preferred label: inheres in
example of usage: this fragility inheres in this vase
example of usage: this fragility is a characteristic of this vase
example of usage: this red color inheres in this apple
example of usage: this red color is a characteristic of this apple
definition: a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
definition: a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence
editor note: A dependent inheres in its bearer at all times for which the dependent exists.
alternative term: 'inheres in at all times'
alternative term: inheres_in
imported from: dron.owl
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
imported from: http://purl.obolibrary.org/obo/ro.owl
temporal interpretation: axiom holds for all times
comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
label: inheres in

bearer of
type: ObjectProperty
type: InverseFunctionalProperty
range: specifically dependent continuant
editor preferred label: bearer of
example of usage: this apple is bearer of this red color
example of usage: this vase is bearer of this fragility
definition: Inverse of characteristic_of
definition: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
editor note: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
alternative term: bearer of
alternative term: bearer_of
alternative term: is bearer of
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
temporal interpretation: axiom holds for all times
label: bearer_of
label: has characteristic
label: is bearer of

participates in
type: ObjectProperty
inverse of: has_participant
domain: continuant
range: occurrent
editor preferred label: participates in
example of usage: this blood clot participates in this blood coagulation
example of usage: this input material (or this output material) participates in this process
example of usage: this investigator participates in this investigation
definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process
alternative term: participates_in
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl

has_participant
type: ObjectProperty
sub property of: topObjectProperty
domain: occurrent
range: continuant
property chain axiom: has part
property chain axiom: realizes
property chain axiom: characteristic of
editor preferred label: has participant
example of usage: this blood coagulation has participant this blood clot
example of usage: this investigation has participant this investigator
example of usage: this process has participant this input material (or this output material)
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
editor note: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
alternative term: has_participant
imported from: dron.owl
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
imported from: http://purl.obolibrary.org/obo/ro.owl
Source: http://www.obofoundry.org/ro/#OBO_REL:has_participant
label: has participant

concretizes
type: ObjectProperty
sub property of: topObjectProperty
domain: specifically dependent continuant
range: generically dependent continuant
editor preferred label: concretizes
example of usage: A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant).
example of usage: An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process).
definition: A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant.
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
comment: It is recommended to not use this if possible in OMRSE. According to OntoBee this relation has been obsoleted and replaced with 'concretization of at all times'. As of Dec. 2, 2013 iao-main still uses this relation.

function of
type: ObjectProperty
sub property of: characteristic of
inverse of: has function
domain: function
example of usage: this catalysis function is a function of this enzyme
definition: a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
editor note: A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists.
alternative term: function_of
alternative term: is function of
imported from: Ontology for Biomedical Investigations

role of
type: ObjectProperty
sub property of: characteristic of
inverse of: has role
example of usage: this investigator role is a role of this person
definition: a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
editor note: A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.
alternative term: is role of
alternative term: role_of
imported from: Ontology for Biomedical Investigations

has function
type: ObjectProperty
sub property of: bearer of
domain: independent continuant
range: function
example of usage: this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)
definition: a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
editor note: A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
alternative term: has_function
imported from: Ontology for Biomedical Investigations

has quality
type: ObjectProperty
sub property of: bearer of
range: quality
example of usage: this apple has quality this red color
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
editor note: A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
alternative term: has_quality
imported from: envo.owl

has role
type: ObjectProperty
sub property of: bearer of
domain: independent continuant
range: role
example of usage: this person has role this investigator role (more colloquially: this person has this role of investigator)
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
editor note: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
alternative term: has_role
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

derives from
type: ObjectProperty
sub property of: topObjectProperty
inverse of: derives into
domain: independent continuant
range: independent continuant
editor preferred label: derives from
example of usage: this cell derives from this parent cell (cell division)
example of usage: this nucleus derives from this parent nucleus (nuclear division)
has curation status: pending final vetting
definition: a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
editor note: This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'.
alternative term: derives_from
imported from: Ontology for Biomedical Investigations
imported from: ro.owl

derives into
type: ObjectProperty
example of usage: this parent cell derives into this cell (cell division)
example of usage: this parent nucleus derives into this nucleus (nuclear division)
has curation status: pending final vetting
definition: a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
editor note: This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'.
alternative term: derives_into
imported from: Ontology for Biomedical Investigations

location_of
type: ObjectProperty
inverse of: located_in
type: TransitiveProperty
editor preferred label: is location of
example of usage: my head is the location of my brain
example of usage: this cage is the location of this rat
definition: a relation between two independent continuants, the location and the target, in which the target is entirely within the location
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: location_of
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
database_cross_reference: RO:0001015
has_obo_namespace: uberon
id: location_of
shorthand: location_of
label: location of

located_in
type: ObjectProperty
type: TransitiveProperty
property chain axiom: subClassOf
editor preferred label: located in
example of usage: my brain is located in my head
example of usage: this rat is located in this cage
definition: a relation between two independent continuants, the target and the location, in which the target is entirely within the location
editor note: Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: located_in
imported from: envo.owl
imported from: gaz.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
Source: http://www.obofoundry.org/ro/#OBO_REL:located_in
database_cross_reference: RO:0001025
has_obo_namespace: file:/Users/michaelashburner/Desktop/gaz/gaz.oboInOwl
has_obo_namespace: uberon
id: located_in
shorthand: located_in
label: located in
label: located_in (type level)

has boundary
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002002
has_obo_namespace: uberon
id: has_boundary
shorthand: has_boundary

bounding layer of
type: ObjectProperty
sub property of: part of
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002007
has_obo_namespace: uberon
id: bounding_layer_of
shorthand: bounding_layer_of
comment: A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.

before or simultaneous with
type: ObjectProperty
sub property of: temporally related to
definition editor: David Osumi-Sutherland
alternative term: <=
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: Primitive instance level timing relation between events

simultaneous_with
type: ObjectProperty
sub property of: before or simultaneous with
sub property of: starts
sub property of: ends
type: TransitiveProperty
definition: Relation between occurrents, shares start and end boundaries.
definition editor: David Osumi-Sutherland
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002082
has exact synonym: coincides_with
has exact synonym: is_equal_to
has_obo_namespace: uberon
id: simultaneous_with
in subset: ro-eco
shorthand: simultaneous_with
comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
label: simultaneous with

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
property chain axiom: ends during
property chain axiom: preceded_by
definition editor: David Osumi-Sutherland
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)

immediately_preceded_by
type: ObjectProperty
sub property of: preceded_by
inverse of: immediately precedes
property chain axiom: starts with
property chain axiom: ends with
definition: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
definition editor: David Osumi-Sutherland
alternative term: starts_at_end_of
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
external_definition: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
database_cross_reference: RO:0002087
has exact synonym: directly preceded by
has exact synonym: is directly preceded by
has exact synonym: is immediately preceded by
has exact synonym: starts_at_end_of
has_obo_namespace: uberon
id: immediately_preceded_by
shorthand: immediately_preceded_by
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
label: immediately preceded by

immediately precedes
type: ObjectProperty
sub property of: precedes
property chain axiom: ends with
property chain axiom: starts with
definition editor: David Osumi-Sutherland
alternative term: ends_at_start_of
alternative term: meets
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
is direct form of: precedes
in subset: ro-eco
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)

starts during
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
definition editor: David Osumi-Sutherland
alternative term: io
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
definition editor: David Osumi-Sutherland
alternative term: d
alternative term: during
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

ends during
type: ObjectProperty
sub property of: temporally related to
definition editor: David Osumi-Sutherland
alternative term: o
alternative term: overlaps
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).

overlaps
type: ObjectProperty
sub property of: mereotopologically related to
property chain axiom: part of
property chain axiom: has part
has curation status: pending final vetting
definition: x overlaps y if and only if there exists some z such that x has part z and z part of y
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
temporal interpretation: axiom holds for all times
in subset: ro-eco

spatially disjoint from
type: ObjectProperty
sub property of: mereotopologically related to
has curation status: pending final vetting
definition: A is spatially_disjoint_from B if and only if they have no parts in common
editor note: There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom.
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
curator note: Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy
imported from: envo.owl
expand expression to: BFO_0000051 exactly 0 (BFO_0000050 some ?Y)
temporal interpretation: axiom holds for all times
in subset: ro-eco

connects
type: ObjectProperty
definition: Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.
editor note: this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002176
has_obo_namespace: uberon
id: connects
shorthand: connects

develops_from
type: ObjectProperty
sub property of: has developmental contribution from
sub property of: determined by
inverse of: develops_into
type: TransitiveProperty
property chain axiom: part of
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002202
has_obo_namespace: uberon
id: develops_from
shorthand: develops_from

develops_into
type: ObjectProperty
sub property of: has potential to develop into
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002203
has_obo_namespace: uberon
id: develops_into
shorthand: develops_into

regulates (processual)
type: ObjectProperty
sub property of: causally upstream of
inverse of: regulated by
type: TransitiveProperty
domain: process
range: process
property chain axiom: ends with
property chain axiom: directly regulates
has curation status: pending final vetting
definition: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
editor note: We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit
definition editor: Chris Mungall
definition editor: David Hill
definition editor: Tanya Berardini
definition source: causal-relations
definition source: GO
curator note: Regulation precludes parthood; the regulatory process may not be within the regulated process.
imported from: envo.owl
OBO foundry unique label: regulates (processual)
elucidation: false
label: regulates

capable of
type: ObjectProperty
sub property of: capable of part of
domain: independent continuant
range: process
example of usage: mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)
example of usage: osteoclast SubClassOf 'capable of' some 'bone resorption'
has curation status: pending final vetting
definition: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
definition editor: Chris Mungall
alternative term: has function realized in
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20123131
definition source: http://www.ncbi.nlm.nih.gov/pubmed/21208450
curator note: For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".
imported from: envo.owl
expand expression to: RO_0000053 some (RO_0000054 only ?Y)
in subset: ro-eco

capable of part of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal agent in
property chain axiom: capable of
property chain axiom: part of
has curation status: pending final vetting
definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
definition editor: Chris Mungall
alternative term: has function in
imported from: envo.owl
expand expression to: RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))

has active participant
type: ObjectProperty
sub property of: has_participant
example of usage: 'heart development' has active participant some Shh protein
has curation status: pending final vetting
definition: x has participant y if and only if x realizes some active role that inheres in y
editor note: This may be obsoleted and replaced by the original 'has agent' relation
definition editor: Chris Mungall
alternative term: has agent
imported from: envo.owl
imported from: omrse.owl
in subset: ro-eco

surrounded by
type: ObjectProperty
sub property of: adjacent_to
inverse of: surrounds
has curation status: pending final vetting
definition: x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
definition: x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y
definition editor: Chris Mungall
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
database_cross_reference: RO:0002219
has_obo_namespace: uberon
id: surrounded_by
shorthand: surrounded_by
label: surrounded_by

adjacent_to
type: ObjectProperty
sub property of: spatially disjoint from
type: SymmetricProperty
domain: independent continuant
range: independent continuant
example of usage: A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts.
example of usage: The epidermis layer of a vertebrate is adjacent to the dermis.
example of usage: The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies.
example of usage: The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used.
has curation status: pending final vetting
definition: x adjacent to y if and only if x and y share a boundary.
definition: x adjacent_to y iff: x and y share a boundary
editor note: This relation acts as a join point with BSPO
definition editor: Chris Mungall
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
database_cross_reference: RO:0002220
has_obo_namespace: uberon
id: adjacent_to
shorthand: adjacent_to
label: adjacent to

surrounds
type: ObjectProperty
sub property of: adjacent_to
has curation status: pending final vetting
definition: inverse of surrounded by
definition: inverse of surrounded_by
definition editor: Chris Mungall
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
database_cross_reference: RO:0002221
has_obo_namespace: uberon
id: surrounds
in subset: RO_0002259
shorthand: surrounds

temporally related to
type: ObjectProperty
domain: occurrent
range: occurrent
has curation status: pending final vetting
definition editor: Chris Mungall
definition source: Allen's interval algebra
curator note: Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
Source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
in subset: ro-eco
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

starts
type: ObjectProperty
sub property of: part of
inverse of: starts with
definition: Relation between occurrents, shares a start boundary with.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002223
has_obo_namespace: uberon
id: starts
shorthand: starts

starts with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
example of usage: Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor
has curation status: pending final vetting
definition: x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: Chris Mungall
alternative term: started by
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002224
has_obo_namespace: uberon
id: starts_with
in subset: ro-eco
shorthand: starts_with

ends
type: ObjectProperty
sub property of: part of
definition: Relation between occurrents, shares an end boundary with.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002229
has exact synonym: finishes
has_obo_namespace: uberon
id: ends
shorthand: ends

ends with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
has curation status: pending final vetting
definition: x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: Chris Mungall
alternative term: finished by
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002230
has_obo_namespace: uberon
id: ends_with
in subset: ro-eco
shorthand: ends_with

has input
type: ObjectProperty
sub property of: has_participant
inverse of: input of
domain: process
range: material entity
property chain axiom: starts with
has curation status: pending final vetting
definition: p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p.
definition editor: Chris Mungall
alternative term: consumes
imported from: envo.owl
in subset: ro-eco

has output
type: ObjectProperty
sub property of: has_participant
inverse of: output of
property chain axiom: ends with
has curation status: pending final vetting
definition: p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p.
definition editor: Chris Mungall
alternative term: produces
imported from: envo.owl
in subset: ro-eco

has developmental contribution from
type: ObjectProperty
sub property of: determined by
type: TransitiveProperty
property chain axiom: has part
property chain axiom: develops_from
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002254
has_obo_namespace: uberon
id: has_developmental_contribution_from
shorthand: has_developmental_contribution_from

developmentally_induced_by
type: ObjectProperty
definition: t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002256
has_obo_namespace: uberon
id: developmentally_induced_by
shorthand: developmentally_induced_by
comment: sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)

developmentally preceded by
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002258
has_obo_namespace: uberon
id: developmentally_preceded_by
shorthand: developmentally_preceded_by

developmentally_replaces
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002285
has_obo_namespace: uberon
id: developmentally_replaces
shorthand: developmentally_replaces

inheres in part of
type: ObjectProperty
sub property of: depends on
property chain axiom: characteristic of
property chain axiom: part of
definition: q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w.
editor note: Because part_of is transitive, inheres in is a sub-relation of inheres in part of
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
imported from: envo.owl
temporal interpretation: axiom holds for all times

mereotopologically related to
type: ObjectProperty
definition: A mereological relationship or a topological relationship
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
temporal interpretation: axiom holds for all times

enables
type: ObjectProperty
sub property of: capable of
inverse of: enabled by
example of usage: a particular instances of akt-2 enables some instance of protein kinase activity
definition editor: Chris Mungall
alternative term: catalyzes
alternative term: executes
alternative term: has
alternative term: is catalyzing
alternative term: is executing
curator note: This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
curator note: This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.
imported from: envo.owl

functionally related to
type: ObjectProperty
definition editor: Chris Mungall
curator note: This is a grouping relation that collects relations used for the purpose of connecting structure and function
imported from: envo.owl

enabled by
type: ObjectProperty
sub property of: functionally related to
sub property of:
  inverse of: capable of
definition: inverse of enables
definition editor: Chris Mungall
imported from: envo.owl

regulated by
type: ObjectProperty
sub property of: causally downstream of or within
type: TransitiveProperty
domain: process
range: process
definition: inverse of regulates
definition editor: Chris Mungall
imported from: envo.owl
OBO foundry unique label: regulated by (processual)
in subset: RO_0002259

member of
type: ObjectProperty
sub property of: part of
inverse of: has member
example of usage: An organism that is a member of a population of organisms
definition: is member of is a mereological relation between a item and a collection.
alternative term: is member of
alternative term: member part of
definition source: SIO
imported from: omrse.owl
temporal interpretation: axiom holds for all times

has member
type: ObjectProperty
sub property of: has part
type: IrreflexiveProperty
definition: has member is a mereological relation between a collection and an item.
definition source: SIO
imported from: oae.owl
imported from: omrse.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
database_cross_reference: RO:0002351
has_obo_namespace: uberon
id: has_member
shorthand: has_member

input of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: inverse of has input
definition editor: Chris Mungall
imported from: envo.owl
in subset: RO_0002259
in subset: ro-eco

output of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: inverse of has output
definition editor: Chris Mungall
imported from: envo.owl
in subset: RO_0002259
in subset: ro-eco

formed as result of
type: ObjectProperty
sub property of: output of
definition editor: Chris Mungall
imported from: envo.owl

has potential to develop into
type: ObjectProperty
definition: x has the potential to develop into y iff x develops into y or if x is capable of developing into y
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002387
has_obo_namespace: uberon
id: has_potential_to_develop_into
shorthand: has_potential_to_develop_into

causally related to
type: ObjectProperty
sub property of: related via dependence to
has curation status: requires discussion
definition: This relation groups causal relations between material entities and causal relations between processes
editor note: This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yiel…
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: envo.owl

causally upstream of
type: ObjectProperty
sub property of: precedes
sub property of: causally upstream of or within
type: TransitiveProperty
has curation status: requires discussion
definition: p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain
definition editor: Chris Mungall
imported from: envo.owl

immediately causally upstream of
type: ObjectProperty
sub property of: immediately precedes
sub property of: causally upstream of
has curation status: requires discussion
definition: p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.
definition editor: Chris Mungall
imported from: envo.owl
is direct form of: causally upstream of

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
inverse of: causally downstream of or within
type: TransitiveProperty
definition: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
editor note: We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2
definition editor: Chris Mungall
alternative term: influences (processual)
imported from: envo.owl
has_related_synonym: affects

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
definition: inverse of causally upstream of or within
definition editor: Chris Mungall
definition source: causal-relations
imported from: envo.owl
in subset: RO_0002259

contributes to morphology of
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002433
has_obo_namespace: uberon
id: contributes_to_morphology_of
shorthand: contributes_to_morphology_of

composed primarily of
type: ObjectProperty
sub property of: has part
example of usage: 'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'
definition: x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
definition: x composed_primarily_of y iff: more than half of the mass of x is made from parts of y
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: axiom holds for all times
has_alternative_id: UBREL:0000002
database_cross_reference: RO:0002473
has_obo_namespace: uberon
id: composed_primarily_of
in subset: ro-eco
shorthand: composed_primarily_of

existence starts during
type: ObjectProperty
sub property of: existence starts during or after
property chain axiom: part of
definition: Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: BFO:0000068
database_cross_reference: RO:0002488
has exact synonym: begins_to_exist_during
has_obo_namespace: uberon
id: existence_starts_during
shorthand: existence_starts_during

existence starts with
type: ObjectProperty
sub property of: existence starts during
definition: Relation between continuant and occurrent, such that c comes into existence at the start of p.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002489
has_obo_namespace: uberon
id: existence_starts_with
shorthand: existence_starts_with

existence ends during
type: ObjectProperty
sub property of: existence ends during or before
property chain axiom: part of
definition: Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: BFO:0000069
database_cross_reference: RO:0002492
has exact synonym: ceases_to_exist_during
has_obo_namespace: uberon
id: existence_ends_during
shorthand: existence_ends_during

existence ends with
type: ObjectProperty
sub property of: existence ends during
definition: Relation between continuant and occurrent, such that c ceases to exist at the end of p.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002493
has_obo_namespace: uberon
id: existence_ends_with
shorthand: existence_ends_with

transformation of
type: ObjectProperty
sub property of: develops_from
type: TransitiveProperty
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002494
has exact synonym: transforms from
has_obo_namespace: uberon
id: transformation_of
shorthand: transformation_of

immediate transformation of
type: ObjectProperty
sub property of: transformation of
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002495
has exact synonym: direct_transformation_of
has exact synonym: immediately transforms from
has_obo_namespace: uberon
id: immediate_transformation_of
shorthand: immediate_transformation_of

existence starts during or after
type: ObjectProperty
property chain axiom: part of
property chain axiom: developmentally preceded by
property chain axiom: preceded_by
property chain axiom: simultaneous_with
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002496
has_obo_namespace: uberon
id: existence_starts_during_or_after
shorthand: existence_starts_during_or_after

existence ends during or before
type: ObjectProperty
property chain axiom: part of
property chain axiom: precedes
property chain axiom: simultaneous_with
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002497
has_obo_namespace: uberon
id: existence_ends_during_or_before
shorthand: existence_ends_during_or_before

causal agent in
type: ObjectProperty
sub property of: causal relation between material entity and a process
inverse of: has causal agent
definition: A relationship between a material entity and a process where the material entity has some causal role that influences the process
definition source: causal-relations
imported from: envo.owl

causal relation between processes
type: ObjectProperty
sub property of: causally related to
domain: occurrent
range: occurrent
definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
definition editor: Chris Mungall
definition source: causal-relations
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: envo.owl

depends on
type: ObjectProperty
definition editor: Chris Mungall
imported from: envo.owl

causal relation between material entities
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: material entity
editor note: The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch
definition editor: Chris Mungall
definition source: causal-relations
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: envo.owl

determined by
type: ObjectProperty
sub property of: part of
sub property of: determined by part of
sub property of: causally influenced by
inverse of: determines
type: TransitiveProperty
domain: system
range: material entity
property chain axiom: has part
property chain axiom: develops_from
example of usage: A coral reef environment is determined by a particular coral reef
definition: s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s.
editor note: The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/24330602
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
OBO foundry unique label: determined by (system to material entity)
creator: Chris Mungall
creator: Pier Buttigieg
database_cross_reference: RO:0002507
has_obo_namespace: uberon
id: has_material_contribution_from
in subset: ro-eco
shorthand: has_material_contribution_from
label: has material contribution from

determines
type: ObjectProperty
sub property of: causally influences
definition: inverse of determined by
definition editor: Chris Mungall
imported from: envo.owl
OBO foundry unique label: determines (material entity to system)
in subset: RO_0002259
in subset: ro-eco

determined by part of
type: ObjectProperty
sub property of: overlaps
sub property of: causal relation between material entities
domain: system
range: material entity
property chain axiom: determined by
property chain axiom: part of
definition: s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w.
definition editor: Chris Mungall
imported from: envo.owl
in subset: ro-eco

has skeleton
type: ObjectProperty
sub property of: has part
inverse of: skeleton of
definition: A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002551
has_obo_namespace: uberon
has_related_synonym: has sekeletal support
has_related_synonym: has supporting framework
id: has_skeleton
shorthand: has_skeleton

causally influenced by
type: ObjectProperty
sub property of: causal relation between material entities
inverse of: causally influences
definition editor: Chris Mungall
definition source: causal-relations
imported from: envo.owl
OBO foundry unique label: causally influenced by (material entity to material entity)

causally influences
type: ObjectProperty
sub property of: causal relation between material entities
property chain axiom: enables
property chain axiom: causally upstream of
property chain axiom: has input
property chain axiom: enabled by
definition: Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b
definition editor: Chris Mungall
definition source: causal-relations
imported from: envo.owl
OBO foundry unique label: causally influences (material entity to material entity)

luminal space of
type: ObjectProperty
sub property of: part of
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002572
has_obo_namespace: uberon
id: luminal_space_of
shorthand: luminal_space_of

skeleton of
type: ObjectProperty
sub property of: part of
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002576
has_obo_namespace: uberon
id: skeleton_of
shorthand: skeleton_of

directly regulates
type: ObjectProperty
sub property of: regulates (processual)
sub property of: immediately causally upstream of
definition: Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
definition editor: Chris Mungall
definition source: causal-relations
imported from: envo.owl
OBO foundry unique label: directly regulates (processual)
is direct form of: regulates (processual)

causal relation between material entity and a process
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: process
definition: A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
editor note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
definition editor: Chris Mungall
definition source: causal-relations
imported from: envo.owl

has causal agent
type: ObjectProperty
sub property of: causally related to
definition: Inverse of 'causal agent in'
definition source: causal-relations
imported from: envo.owl

related via dependence to
type: ObjectProperty
definition: A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: envo.owl

produces
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0003000
has_obo_namespace: uberon
id: produces
shorthand: produces

produced_by
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0003001
has_obo_namespace: uberon
id: produced_by
shorthand: produced_by

channel for
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: carries
has_obo_namespace: uberon
id: channel_for

conduit for
type: ObjectProperty
definition: x is a conduit for y iff y passes through the lumen of x.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: conduit_for

existence starts and ends during
type: ObjectProperty
sub property of: existence starts during
sub property of: existence ends during
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: existence_starts_and_ends_during

in_central_side_of
type: ObjectProperty
sub property of: part of
definition: X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: in_central_side_of

subdivision of
type: ObjectProperty
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: subdivision_of
comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B

has_proper_part
type: ObjectProperty
sub property of: topObjectProperty
type: TransitiveProperty
imported from: dron.owl
imported from: http://purl.org/obo/owl/relationship
has_alternative_id: OBO_REL:0000007
has_obo_namespace: relationship

has measurement value
type: DatatypeProperty
sub property of: topDataProperty
type: FunctionalProperty
domain: scalar measurement datum
range: double
imported from: iao.owl

has digit number
type: DatatypeProperty
range: integer
example of usage: The data type "last 4 digits of social security number" has digit number of 4.
definition: A data property that represents a relation between a data type and a number of integer digits that the data type has.
definition editor: Oliver He

quality measured by year
type: DatatypeProperty
domain: quality
range: integer

entity
type: Class
subclass of: Thing
BFO OWL specification label: entity
BFO CLIF specification label: Entity
editor preferred label: entity
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: ico.owl
imported from: mondo.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])

continuant
type: Class
subclass of: entity
BFO OWL specification label: continuant
BFO CLIF specification label: Continuant
editor preferred label: continuant
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: pato.owl
imported from: ro.owl
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]

occurrent
type: Class
subclass of: entity
BFO OWL specification label: occurrent
BFO CLIF specification label: Occurrent
editor preferred label: occurrent
definition: An entity that has temporal parts and that happens, unfolds or develops through time.
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: ico.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: ro.owl
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]

independent continuant
type: Class
subclass of: continuant
BFO OWL specification label: ic
BFO CLIF specification label: IndependentContinuant
example of usage: a chair
example of usage: a heart
example of usage: a leg
example of usage: a molecule
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
definition: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]

temporal region
type: Class
subclass of: occurrent
BFO OWL specification label: t-region
BFO CLIF specification label: TemporalRegion
editor note: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
elucidation: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has associated axiom(nl): All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has associated axiom(nl): Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has associated axiom(fol): (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has associated axiom(fol): (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has associated axiom(fol): (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]

process
type: Class
subclass of: occurrent
BFO OWL specification label: process
BFO CLIF specification label: Process
editor preferred label: process
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
example of usage: the course of a disease
example of usage: the flight of a bird
example of usage: the life of an organism
example of usage: your process of aging.
definition: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: ico.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: ro.owl
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]

disposition
type: Class
subclass of: realizable entity
BFO OWL specification label: disposition
BFO CLIF specification label: Disposition
example of usage: an atom of element X has the disposition to decay to an atom of element Y
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
imported from: Ontology for Biomedical Investigations
imported from: ogms.owl
imported from: omrse.owl
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]

realizable entity
type: Class
subclass of: specifically dependent continuant
BFO OWL specification label: realizable
BFO CLIF specification label: RealizableEntity
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
imported from: dron.owl
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]

quality
type: Class
subclass of: specifically dependent continuant
BFO OWL specification label: quality
BFO CLIF specification label: Quality
editor preferred label: quality
example of usage: the ambient temperature of this portion of air
example of usage: the color of a tomato
example of usage: the length of the circumference of your waist
example of usage: the mass of this piece of gold.
example of usage: the shape of your nose
example of usage: the shape of your nostril
imported from: bfo.owl
imported from: envo.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: pato.owl
imported from: ro.owl
elucidation: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
has associated axiom(nl): If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
has associated axiom(fol): (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
has associated axiom(fol): (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]

specifically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: sdc
BFO CLIF specification label: SpecificallyDependentContinuant
editor preferred label: specifically dependent continuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
definition: b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: pato.owl
imported from: ro.owl
has associated axiom(fol): (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]

role
type: Class
subclass of: realizable entity
BFO OWL specification label: role
BFO CLIF specification label: Role
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
definition: A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
imported from: dron.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]

fiat object
type: Class
subclass of: material entity
imported from: envo.owl
label: fiat object part

object aggregate
type: Class
subclass of: material entity
BFO OWL specification label: object-aggregate
BFO CLIF specification label: ObjectAggregate
example of usage: a collection of cells in a blood biobank.
example of usage: a swarm of bees is an aggregate of members who are linked together through natural bonds
example of usage: a symphony orchestra
example of usage: an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)
example of usage: defined by fiat: the aggregate of members of an organization
example of usage: defined through physical attachment: the aggregate of atoms in a lump of granite
example of usage: defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container
example of usage: defined via attributive delimitations such as: the patients in this hospital
example of usage: the aggregate of bearings in a constant velocity axle joint
example of usage: the aggregate of blood cells in your body
example of usage: the nitrogen atoms in the atmosphere
example of usage: the restaurants in Palo Alto
example of usage: your collection of Meissen ceramic plates.
editor note: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
editor note: BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee).
definition source: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
imported from: dron.owl
imported from: envo.owl
elucidation: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
has associated axiom(fol): (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]

site
type: Class
subclass of: immaterial entity
BFO OWL specification label: site
BFO CLIF specification label: Site
example of usage: Manhattan Canyon)
example of usage: a hole in the interior of a portion of cheese
example of usage: a rabbit hole
example of usage: an air traffic control region defined in the airspace above an airport
example of usage: the Grand Canyon
example of usage: the Piazza San Marco
example of usage: the cockpit of an aircraft
example of usage: the hold of a ship
example of usage: the interior of a kangaroo pouch
example of usage: the interior of the trunk of your car
example of usage: the interior of your bedroom
example of usage: the interior of your office
example of usage: the interior of your refrigerator
example of usage: the lumen of your gut
example of usage: your left nostril (a fiat part – the opening – of your left nasal cavity)
imported from: envo.owl
imported from: iao.owl
imported from: omrse.owl
elucidation: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has associated axiom(fol): (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]

object
type: Class
subclass of: material entity
BFO OWL specification label: object
BFO CLIF specification label: Object
example of usage: atom
example of usage: cell
example of usage: cells and organisms
example of usage: engineered artifacts
example of usage: grain of sand
example of usage: molecule
example of usage: organelle
example of usage: organism
example of usage: planet
example of usage: solid portions of matter
example of usage: star
editor note: BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
editor note: BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
editor note: BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
editor note: BFO 2 Reference: an object is a maximal causally unified material entity
editor note: BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
imported from: dron.owl
imported from: envo.owl
elucidation: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])

generically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: gdc
BFO CLIF specification label: GenericallyDependentContinuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
definition: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
imported from: dron.owl
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]

function
type: Class
subclass of: disposition
BFO OWL specification label: function
BFO CLIF specification label: Function
example of usage: the function of a hammer to drive in nails
example of usage: the function of a heart pacemaker to regulate the beating of a heart through electricity
example of usage: the function of amylase in saliva to break down starch into sugar
editor note: BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl
elucidation: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
has associated axiom(fol): (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]

one-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 1d-t-region
BFO CLIF specification label: OneDimensionalTemporalRegion
example of usage: the temporal region during which a process occurs.
editor note: BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
elucidation: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]

material entity
type: Class
subclass of: independent continuant
BFO OWL specification label: material
BFO CLIF specification label: MaterialEntity
editor preferred label: material entity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
example of usage: the undetached arm of a human being
definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: ido.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: omrse.owl
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]

immaterial entity
type: Class
subclass of: independent continuant
BFO OWL specification label: immaterial
BFO CLIF specification label: ImmaterialEntity
editor note: BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10
imported from: envo.owl
imported from: iao.owl
imported from: omrse.owl

process profile
type: Class
subclass of: process
BFO OWL specification label: process-profile
BFO CLIF specification label: ProcessProfile
example of usage: On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels
example of usage: One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance.
example of usage: The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on.
definition: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
imported from: Ontology for Biomedical Investigations
elucidation: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
has associated axiom(fol): (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
has associated axiom(fol): (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]

zero-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 0d-t-region
BFO CLIF specification label: ZeroDimensionalTemporalRegion
example of usage: a temporal region that is occupied by a process boundary
example of usage: right now
example of usage: the moment at which a child is born
example of usage: the moment at which a finger is detached in an industrial accident
example of usage: the moment of death.
alternative term: temporal instant.
imported from: Ontology for Biomedical Investigations
elucidation: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]

history
type: Class
subclass of: process
BFO OWL specification label: history
BFO CLIF specification label: History
imported from: Ontology for Biomedical Investigations
elucidation: A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001])

organism or virus or viroid
type: Class
subclass of: organismal entity
definition: Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
imported from: envo.owl

antihypotensive agent
type: Class
subclass of: role
definition: A cardiovascular drug that tends to raise reduced blood pressure.
imported from: chebi.owl
database_cross_reference: Wikipedia:Antihypotensive_agent
has_obo_namespace: chebi_ontology
has_related_synonym: antihypotensive agents
has_related_synonym: pressor
has_related_synonym: pressors
has_related_synonym: vasopressor agens
has_related_synonym: vasopressor agent
id: CHEBI:137431
in subset: 3 STAR

peptide
type: Class
subclass of: macromolecule
editor preferred label: peptide
definition: Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
imported from: chebi.owl
imported from: Ontology for Biomedical Investigations

penicillin
type: Class
subclass of: penicillanic acids
definition: Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.
imported from: chebi.owl
imported from: dron.owl
charge: 0
formula: C9H11N2O4SR
mass: 243.26000
monoisotopicmass: 243.04395
has_alternative_id: CHEBI:14742
has_alternative_id: CHEBI:25869
has_alternative_id: CHEBI:7961
database_cross_reference: CiteXplore:12833570
database_cross_reference: CiteXplore:1502708
database_cross_reference: CiteXplore:16033609
database_cross_reference: CiteXplore:7798534
database_cross_reference: KEGG COMPOUND:C00395
database_cross_reference: KEGG:C00395
database_cross_reference: PMID:11851248
database_cross_reference: PMID:12833570
database_cross_reference: PMID:1502708
database_cross_reference: PMID:16033609
database_cross_reference: PMID:7061385
database_cross_reference: PMID:7798534
database_cross_reference: Wikipedia:Penicillin
has exact synonym: Penicillin
has exact synonym: penicillin
has exact synonym: penicillins
has_obo_namespace: chebi_ontology
has_related_synonym: C9H11N2O4SR
has_related_synonym: penicillins
id: CHEBI:17334
in subset: 3 STAR

cephalosporin
type: Class
subclass of: cephem
definition: A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring.
definition: A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy.
imported from: chebi.owl
imported from: dron.owl
charge: 0
formula: C7H5NO3SR2
mass: 183.18500
monoisotopicmass: 182.99901
has_alternative_id: CHEBI:3538
database_cross_reference: CiteXplore:12833570
database_cross_reference: CiteXplore:6762896
database_cross_reference: KEGG COMPOUND:C00875
database_cross_reference: KEGG:C00875
database_cross_reference: PMID:10069359
database_cross_reference: PMID:11936371
database_cross_reference: PMID:12833570
database_cross_reference: PMID:24269048
database_cross_reference: PMID:3320614
database_cross_reference: PMID:6762896
database_cross_reference: PMID:8426246
database_cross_reference: Wikipedia:Cephalosporin
has exact synonym: Cephalosporin
has_obo_namespace: chebi_ontology
has_related_synonym: C7H5NO3SR2
has_related_synonym: cephalosphorin
has_related_synonym: cephalosphorins
has_related_synonym: cephalosporins
id: CHEBI:23066
in subset: 3 STAR

molecular entity
type: Class
subclass of: object
subclass of: material entity
subclass of: chemical entity
editor preferred label: molecular entity
definition: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
editor note: We are assuming that every molecular entity has to be completely connected by chemical bonds. This excludes protein complexes, which are comprised of minimally two separate molecular entities. We will follow up with Chebi to ensure this is their understanding as well
imported from: chebi.owl
imported from: dron.owl
imported from: Ontology for Biomedical Investigations
has exact synonym: molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: entidad molecular
has_related_synonym: entidades moleculares
has_related_synonym: entite moleculaire
has_related_synonym: molecular entities
has_related_synonym: molekulare Entitaet
id: CHEBI:23367
in subset: 3 STAR

cyclic amide
type: Class
subclass of: amide
imported from: dron.owl
has exact synonym: cyclic amide
has_related_synonym: cyclic amides
id: CHEBI:23443

chemical entity
type: Class
subclass of: material entity
definition: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: chemical entity
has_obo_namespace: chebi_ontology
id: CHEBI:24431
in subset: 3 STAR

heterocyclic antibiotic
type: Class
subclass of: organic heterocyclic compound
imported from: dron.owl
id: CHEBI:24531

organic heterocyclic compound
type: Class
subclass of: heteroorganic entity
subclass of: organic cyclic compound
subclass of: heterocyclic compound
definition: A cyclic compound having as ring members atoms of carbon and at least of one other element.
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic heterocycle
has_related_synonym: organic heterocyclic compounds
id: CHEBI:24532
in subset: 3 STAR

hydroxides
type: Class
subclass of: oxygen molecular entity
subclass of: main group molecular entity
subclass of: hydrogen molecular entity
subclass of: polyatomic entity
subclass of: heteroatomic molecular entity
definition: Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24651
in subset: 3 STAR

oxoacid
type: Class
subclass of: hydroxides
definition: A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
imported from: dron.owl
has exact synonym: oxoacid
has exact synonym: oxoacids
has_related_synonym: oxacids
has_related_synonym: oxiacids
has_related_synonym: oxo acid
has_related_synonym: oxy-acids
has_related_synonym: oxyacids
id: CHEBI:24833

lactam
type: Class
subclass of: cyclic amide
subclass of: amide
subclass of: cyclic pseudoketone
subclass of: carboxamide
subclass of: organonitrogen heterocyclic compound
definition: Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: lactam
has exact synonym: lactams
has_obo_namespace: chebi_ontology
has_related_synonym: Laktam
has_related_synonym: Laktame
has_related_synonym: lactams
id: CHEBI:24995
in subset: 3 STAR

molecule
type: Class
subclass of: polyatomic entity
definition: Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
imported from: chebi.owl
has exact synonym: molecule
has_obo_namespace: chebi_ontology
has_related_synonym: Molekuel
has_related_synonym: molecula
has_related_synonym: molecules
has_related_synonym: neutral molecular compounds
id: CHEBI:25367
in subset: 3 STAR

organonitrogen heterocyclic antibiotic
type: Class
subclass of: heterocyclic antibiotic
subclass of: organic heterocyclic compound
subclass of: organonitrogen heterocyclic compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organonitrogen heterocyclic antibiotics
id: CHEBI:25558
in subset: 3 STAR

oxygen molecular entity
type: Class
subclass of: chalcogen molecular entity
imported from: chebi.owl
imported from: dron.owl
has exact synonym: oxygen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: oxygen molecular entities
id: CHEBI:25806
in subset: 3 STAR

penicillanic acids
type: Class
subclass of: carboxylic acid
subclass of: penams
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
id: CHEBI:25865
in subset: 3 STAR

sulfur molecular entity
type: Class
subclass of: chalcogen molecular entity
imported from: dron.owl
has exact synonym: sulfur molecular entity
has_related_synonym: sulfur molecular entities
id: CHEBI:26835

organic heterobicyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heterobicyclic compound
subclass of: organic heteropolycyclic compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterobicyclic compounds
has_related_synonym: organic heterobicyclic compounds
id: CHEBI:27171
in subset: 3 STAR

beta-lactam antibiotic
type: Class
subclass of: organonitrogen heterocyclic antibiotic
subclass of: beta-lactam
definition: An organonitrogen heterocyclic antibiotic that contains a beta-lactam ring.
imported from: chebi.owl
imported from: dron.owl
has_alternative_id: CHEBI:10427
has_alternative_id: CHEBI:22844
database_cross_reference: KEGG:C03438
database_cross_reference: PMID:19254642
database_cross_reference: PMID:22594007
database_cross_reference: Wikipedia:Beta-lactam_antibiotic
has_obo_namespace: chebi_ontology
has_related_synonym: beta-Lactam antibiotics
has_related_synonym: beta-lactam antibiotics
id: CHEBI:27933
in subset: 3 STAR

amide
type: Class
subclass of: nitrogen molecular entity
definition: An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
imported from: chebi.owl
imported from: dron.owl
has_alternative_id: CHEBI:22473
has_alternative_id: CHEBI:2633
database_cross_reference: KEGG COMPOUND:C00241
database_cross_reference: KEGG:C00241
has exact synonym: Amide
has exact synonym: amides
has_obo_namespace: chebi_ontology
id: CHEBI:32988
in subset: 3 STAR

atom
type: Class
subclass of: material entity
editor preferred label: atom
definition: A chemical entity constituting the smallest component of an element having the chemical properties of the element.
imported from: chebi.owl
imported from: Ontology for Biomedical Investigations

organosulfur compound
type: Class
subclass of: sulfur molecular entity
subclass of: chalcogen molecular entity
subclass of: organochalcogen compound
definition: An organosulfur compound is a compound containing at least one carbon-sulfur bond.
imported from: chebi.owl
imported from: dron.owl
has_alternative_id: CHEBI:23010
has_alternative_id: CHEBI:25714
database_cross_reference: Wikipedia:Organosulfur_compounds
has exact synonym: organosulfur compound
has_obo_namespace: chebi_ontology
has_related_synonym: organosulfur compounds
id: CHEBI:33261
in subset: 3 STAR

heteroorganic entity
type: Class
subclass of: organic molecular entity
definition: A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heteroorganic entities
has_related_synonym: organoelement compounds
id: CHEBI:33285
in subset: 3 STAR

pnictogen molecular entity
type: Class
subclass of: p-block molecular entity
imported from: dron.owl
has exact synonym: pnictogen molecular entity
has_related_synonym: pnictogen molecular entities
id: CHEBI:33302

chalcogen molecular entity
type: Class
subclass of: p-block molecular entity
definition: Any p-block molecular entity containing a chalcogen.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: chalcogen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: chalcogen compounds
has_related_synonym: chalcogen molecular entities
id: CHEBI:33304
in subset: 3 STAR

carboxylic acid
type: Class
subclass of: oxoacid
subclass of: carbon oxoacid
subclass of: carbonyl compound
subclass of: organic molecular entity
definition: A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
definition: An oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
imported from: chebi.owl
imported from: dron.owl
charge: 0
formula: CHO2R
mass: 45.01740
monoisotopicmass: 44.99765
smiles: OC([*])=O
has_alternative_id: CHEBI:13428
has_alternative_id: CHEBI:13627
has_alternative_id: CHEBI:23027
database_cross_reference: CiteXplore:17147560
database_cross_reference: CiteXplore:18433345
database_cross_reference: PMID:17147560
database_cross_reference: PMID:18433345
database_cross_reference: Wikipedia:Carboxylic_acid
has exact synonym: carboxylic acid
has exact synonym: carboxylic acids
has_obo_namespace: chebi_ontology
has_related_synonym: CHO2R
has_related_synonym: Carbonsaeure
has_related_synonym: Carbonsaeuren
has_related_synonym: Karbonsaeure
has_related_synonym: OC([*])=O
has_related_synonym: RC(=O)OH
has_related_synonym: acide carboxylique
has_related_synonym: acides carboxyliques
has_related_synonym: acido carboxilico
has_related_synonym: acidos carboxilicos
id: CHEBI:33575
in subset: 3 STAR

main group molecular entity
type: Class
subclass of: molecular entity
definition: A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: main group compounds
has_related_synonym: main group molecular entities
id: CHEBI:33579
in subset: 3 STAR

carbon group molecular entity
type: Class
subclass of: p-block molecular entity
imported from: dron.owl
has exact synonym: carbon group molecular entity
has_related_synonym: carbon group molecular entities
id: CHEBI:33582

cyclic compound
type: Class
subclass of: molecule
subclass of: polyatomic entity
definition: Any molecule that consists of a series of atoms joined together to form a ring.
imported from: chebi.owl
imported from: dron.owl
database_cross_reference: Wikipedia:Cyclic_compound
has_obo_namespace: chebi_ontology
has_related_synonym: cyclic compounds
id: CHEBI:33595
in subset: 3 STAR

hydrogen molecular entity
type: Class
subclass of: s-block molecular entity
imported from: dron.owl
has_related_synonym: hydrogen compounds
has_related_synonym: hydrogen molecular entities
id: CHEBI:33608

bicyclic compound
type: Class
subclass of: cyclic compound
definition: A molecule that features two fused rings.
imported from: dron.owl
has_related_synonym: bicyclic compounds
id: CHEBI:33636

heteropolycyclic compound
type: Class
subclass of: cyclic compound
subclass of: heterocyclic compound
definition: A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.
imported from: chebi.owl
has exact synonym: heteropolycyclic compounds
has_obo_namespace: chebi_ontology
has_related_synonym: polyheterocyclic compounds
id: CHEBI:33671
in subset: 3 STAR

heterobicyclic compound
type: Class
subclass of: cyclic compound
subclass of: bicyclic compound
subclass of: heterocyclic compound
definition: A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: heterobicyclic compounds
has_obo_namespace: chebi_ontology
id: CHEBI:33672
in subset: 3 STAR

s-block molecular entity
type: Class
subclass of: main group molecular entity
definition: An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
imported from: dron.owl
has exact synonym: s-block molecular entity
has_related_synonym: s-block compounds
has_related_synonym: s-block molecular entities
id: CHEBI:33674

p-block molecular entity
type: Class
subclass of: main group molecular entity
definition: A main group molecular entity that contains one or more atoms of a p-block element.
definition: A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element.
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: p-block compounds
has_related_synonym: p-block molecular entities
has_related_synonym: p-block molecular entitiy
id: CHEBI:33675
in subset: 3 STAR

nucleic acid
type: Class
subclass of: macromolecule
editor preferred label: nucleic acid
definition: A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.
imported from: chebi.owl
imported from: Ontology for Biomedical Investigations

organic cyclic compound
type: Class
subclass of: cyclic compound
subclass of: organic molecular entity
subclass of: organic molecule
definition: Any organic molecule that consists of atoms connected in the form of a ring.
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic cyclic compounds
id: CHEBI:33832
in subset: 3 STAR

macromolecule
type: Class
subclass of: molecular entity
editor preferred label: macromolecule
definition: A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
alternative term: polymer
imported from: chebi.owl
imported from: Ontology for Biomedical Investigations

organonitrogen compound
type: Class
subclass of: heteroorganic entity
subclass of: nitrogen molecular entity
definition: Any heteroorganic entity containing at least one carbon-nitrogen bond.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: organonitrogen compounds
has_obo_namespace: chebi_ontology
has_related_synonym: organonitrogens
id: CHEBI:35352
in subset: 3 STAR

carbon oxoacid
type: Class
subclass of: hydroxides
subclass of: organooxygen compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carbon oxoacids
has_related_synonym: oxoacids of carbon
id: CHEBI:35605
in subset: 3 STAR

beta-lactam
type: Class
subclass of: lactam
definition: A beta-lactam is a lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.
definition: A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.
imported from: chebi.owl
imported from: dron.owl
charge: 0
formula: C3H2NOR3
mass: 68.054
monoisotopicmass: 68.01364
smiles: C1(C(N(*)C1*)=O)*
has_alternative_id: CHEBI:10426
has_alternative_id: CHEBI:13203
has_alternative_id: CHEBI:22845
database_cross_reference: KEGG COMPOUND:C01866
database_cross_reference: KEGG:C01866
database_cross_reference: Wikipedia:Beta-lactam
has exact synonym: beta-Lactam
has exact synonym: beta-lactam
has_obo_namespace: chebi_ontology
has_related_synonym: a beta-lactam
has_related_synonym: beta-lactams
id: CHEBI:35627
in subset: 3 STAR

penams
type: Class
subclass of: organic heterobicyclic compound
subclass of: beta-lactam antibiotic
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
definition: Natural and synthetic antibiotics containing the 4-thia-1-azabicyclo[3.2.0]heptan-7-one structure, generally assumed to have the 5R configuration unless otherwise specified.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: penams
has_obo_namespace: chebi_ontology
id: CHEBI:35992
in subset: 3 STAR

polyatomic entity
type: Class
subclass of: molecular entity
definition: Any molecular entity consisting of more than one atom.
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: polyatomic entities
id: CHEBI:36357
in subset: 3 STAR

pseudoketone
type: Class
subclass of: carbonyl compound
imported from: dron.owl
has exact synonym: pseudoketone
has exact synonym: pseudoketones
has_related_synonym: pseudoketones
id: CHEBI:36585

carbonyl compound
type: Class
subclass of: organic oxo compound
subclass of: organooxygen compound
subclass of: organic molecule
definition: Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: carbonyl compounds
has_obo_namespace: chebi_ontology
id: CHEBI:36586
in subset: 3 STAR

organic oxo compound
type: Class
subclass of: organic molecular entity
definition: Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
imported from: dron.owl
has exact synonym: oxo compounds
has_related_synonym: organic oxo compounds
id: CHEBI:36587

cyclic pseudoketone
type: Class
subclass of: pseudoketone
definition: A cyclic compound in which a carbonyl group in a ring is bonded to one or two skeletal heteroatoms.
imported from: dron.owl
has_related_synonym: cyclic pseudoketones
id: CHEBI:36588

organochalcogen compound
type: Class
subclass of: heteroorganic entity
subclass of: chalcogen molecular entity
definition: An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: organochalcogen compound
has_obo_namespace: chebi_ontology
has_related_synonym: organochalcogen compounds
id: CHEBI:36962
in subset: 3 STAR

organooxygen compound
type: Class
subclass of: oxygen molecular entity
subclass of: organochalcogen compound
definition: An organochalcogen compound containing at least one carbon-oxygen bond.
imported from: chebi.owl
imported from: dron.owl
database_cross_reference: CiteXplore:17586126
database_cross_reference: PMID:17586126
has exact synonym: organooxygen compound
has_obo_namespace: chebi_ontology
has_related_synonym: organooxygen compounds
id: CHEBI:36963
in subset: 3 STAR

heteroatomic molecular entity
type: Class
subclass of: polyatomic entity
definition: A molecular entity consisting of two or more chemical elements.
imported from: dron.owl
has_related_synonym: chemical compound
has_related_synonym: heteroatomic molecular entities
id: CHEBI:37577

carboxamide
type: Class
subclass of: amide
subclass of: organonitrogen compound
subclass of: organooxygen compound
definition: An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.
imported from: chebi.owl
charge: 0
formula: CNOR3
mass: 42.01680
monoisotopicmass: 41.99799
smiles: [*]C(=O)N([*])[*]
has_alternative_id: CHEBI:35354
has_alternative_id: CHEBI:35355
has exact synonym: carboxamides
has_obo_namespace: chebi_ontology
has_related_synonym: carboxamides
has_related_synonym: primary carboxamide
id: CHEBI:37622
in subset: 3 STAR

organonitrogen heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organonitrogen compound
definition: Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterocyclic organonitrogen compounds
has_related_synonym: organonitrogen heterocyclic compounds
id: CHEBI:38101
in subset: 3 STAR

organosulfur heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organosulfur compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterocyclic organosulfur compounds
has_related_synonym: organosulfur heterocyclic compounds
id: CHEBI:38106
in subset: 3 STAR

organic heteropolycyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteropolycyclic compound
imported from: chebi.owl
has_alternative_id: CHEBI:25429
has_alternative_id: CHEBI:38075
has_obo_namespace: chebi_ontology
has_related_synonym: organic heteropolycyclic compounds
id: CHEBI:38166
in subset: 3 STAR

cephem
type: Class
subclass of: organic heterobicyclic compound
subclass of: beta-lactam antibiotic
subclass of: beta-lactam
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cephems
id: CHEBI:38311
in subset: 3 STAR

organic molecular entity
type: Class
subclass of: carbon group molecular entity
subclass of: p-block molecular entity
definition: Any molecular entity that contains carbon.
imported from: chebi.owl
imported from: dron.owl
has_alternative_id: CHEBI:25700
has_alternative_id: CHEBI:33244
has_obo_namespace: chebi_ontology
has_related_synonym: organic compounds
has_related_synonym: organic entity
has_related_synonym: organic molecular entities
id: CHEBI:50860
in subset: 3 STAR

nitrogen molecular entity
type: Class
subclass of: pnictogen molecular entity
subclass of: p-block molecular entity
imported from: chebi.owl
imported from: dron.owl
has_alternative_id: CHEBI:25556
has_alternative_id: CHEBI:7594
database_cross_reference: KEGG COMPOUND:C06061
database_cross_reference: KEGG:C06061
has_obo_namespace: chebi_ontology
has_related_synonym: Nitrogenous compounds
has_related_synonym: nitrogen compounds
has_related_synonym: nitrogen molecular entities
id: CHEBI:51143
in subset: 3 STAR

heterocyclic compound
type: Class
subclass of: cyclic compound
definition: A cyclic compound having as ring members atoms of at least two different elements.
imported from: chebi.owl
imported from: dron.owl
has exact synonym: Heterocyclic compound
has_obo_namespace: chebi_ontology
has_related_synonym: compuesto heterociclico
has_related_synonym: compuestos heterociclicos
has_related_synonym: heterocycle
has_related_synonym: heterocyclic compounds
id: CHEBI:5686
in subset: 3 STAR

organic molecule
type: Class
subclass of: molecule
subclass of: organic molecular entity
definition: Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic compound
has_related_synonym: organic compounds
has_related_synonym: organic molecules
id: CHEBI:72695
in subset: 3 STAR

cell
type: Class
subclass of: material entity
editor preferred label: cell
example of usage: PMID:18089833.Cancer Res. 2007 Dec 15;67(24):12018-25. "...Epithelial cells were harvested from histologically confirmed adenocarcinomas .."
definition: A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
imported from: cl.owl
imported from: Ontology for Biomedical Investigations

cultured cell
type: Class
subclass of: experimentally modified cell in vitro
subclass of: Class
  union of: Restriction
    on property: is_specified_output_of
    some values from: establishing cell culture
  union of: Restriction
    on property: derives from
    some values from: Restriction
      on property: is_specified_output_of
      some values from: establishing cell culture
editor preferred label: cultured cell
definition: A cell in vitro that is or has been maintained or propagated as part of a cell culture.
imported from: cl.owl
imported from: Ontology for Biomedical Investigations

experimentally modified cell in vitro
type: Class
subclass of: cell
subclass of: processed material
subclass of: Restriction
  on property: is_specified_output_of
  some values from: material processing
editor preferred label: experimentally modified cell in vitro
definition: A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.
imported from: cl.owl
imported from: Ontology for Biomedical Investigations

clinical measurement
type: Class
subclass of: measurement datum
imported from: cmo.owl
def: A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation.

cardiovascular measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels.

heart rate
type: Class
subclass of: heart measurement
imported from: cmo.owl
def: The number of contractions of the cardiac ventricles per unit of time.

blood pressure measurement
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
def: Measurement of the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood.
has related synonym: Not4Curation

systolic blood pressure
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
def: The maximum arterial pressure within the cardiac cycle, i.e. at the point at which the heart is in its maximal state of contraction. This is the time when the blood is forced from the ventricles of the heart into the pulmonary artery and the aorta.

diastolic blood pressure
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
def: The minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.

left ventricular diastolic blood pressure
type: Class
subclass of: diastolic blood pressure
imported from: cmo.owl
def: The minimum pressure in the heart left ventricle, usually at the point at which the heart is in a state of relaxation and expansion and the ventricles fill with blood.

left ventricular systolic blood pressure
type: Class
subclass of: systolic blood pressure
imported from: cmo.owl
def: Measurement of the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta.

calculated blood pressure
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
def: A blood pressure measurement which has been normalized or adjusted by a mathematical process or computation. Blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood.
has related synonym: Not4Curation

mean arterial blood pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
def: The average blood pressure within an artery over a specified period of time. It is often calculated using the formula of one third systolic pressure plus two thirds diastolic pressure, or alternatively, using the formula diastolic pressure plus 1/3 of the difference between systolic pressure and diastolic pressure (i.e. 1/3 pulse pressure).

developed blood pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
def: A calculated value for the difference between the systolic blood pressure and the diastolic blood pressure at a given point in time when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

body temperature
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: The level of heat in an organism.

heart morphological measurement
type: Class
subclass of: organ morphological measurement
subclass of: heart measurement
imported from: cmo.owl
def: A measurement of the physical form or structure of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system.
comment: This is the term which was just "heart measurement". Since it was under body morphological measurement it seemed to clearly refer to a morphological measurement. I made this term more specific so that another term for "heart measurement" could be added to the ontology above it which would also be a parent to other non-morphological heart-related terms. JRS 2-15-2012.

heart weight
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
def: The heaviness of the heart (the central cardiac muscle which maintains the circulation of the blood) or the degree to which it is drawn to the earth by gravity.

left ventricular developed pressure
type: Class
subclass of: developed blood pressure
subclass of: calculated left ventricular blood pressure
imported from: cmo.owl
def: A calculated measurement of the difference between the systolic pressure and the diastolic pressure in the heart left ventricle at a given point in time in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

body morphological measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: Measurement of the structure or forms of the entire body or parts of the body of an organism.
has related synonym: anthropometric measurement
has related synonym: morphometry

blood chemistry measurement
type: Class
subclass of: blood measurement
imported from: cmo.owl
def: A quantification of a parameter of the chemical composition of blood.
has related synonym: blood molecular composition measurement

calculated differential white blood cell count
type: Class
subclass of: blood differential white blood cell count
subclass of: white blood cell measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:32:58Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of one or more of the various, specific types of leukocytes present in a sample of blood for which a total white blood cell count was taken, usually 1 cubic mm of peripheral venous blood.
has related synonym: calculated blood differential WBC count
has related synonym: calculated blood differential leukocyte count

blood hemoglobin level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
def: The amount of hemoglobin in a specific volume of blood, expressed as grams per deciliter of whole blood in humans.
has exact synonym: blood haemoglobin level

white blood cell count
type: Class
subclass of: immune cell count
subclass of: white blood cell measurement
imported from: cmo.owl
def: The number of white blood cells in a specified volume of blood.
has related synonym: leukocyte count
has related synonym: white corpuscle count

blood protein measurement
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in blood.

platelet count
type: Class
subclass of: blood cell measurement
imported from: cmo.owl
def: The number of platelets (thrombocytes) in a specified volume of blood, usually expressed as platelets per cubic millimeter of whole blood.

blood measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: A measurement of the blood, it's contents, cells or other factors contained within the blood.

blood cell measurement
type: Class
subclass of: blood measurement
subclass of: cell measurement
imported from: cmo.owl
def: A value resulting from the quantification of a morphological or physiological parameter of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.

blood urea nitrogen level
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: The level of urea in the blood in terms of nitrogen content; converted to urea concentration by multiplying by 60/28 or 2.14. Urea is the chief nitrogenous end product of protein metabolism in whole blood. Urea is formed in the liver from amino acids and from ammonia compounds and can be found in urine, blood, and lymph.
has related synonym: BUN level

blood lipid measurement
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: Any value resulting from the quantification of a morphological or physiological parameter of a blood-derived lipid, any of a structurally diverse group of organic compounds found in blood that are insoluble in water but soluble innonpolar solvents that, among other biological functions, serve as a source of fuel and are an important constituent of cell structure.

blood total cholesterol level
type: Class
subclass of: blood lipoprotein level
subclass of: blood cholesterol level
imported from: cmo.owl
def: Measurement of the entire amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, without taking into account any association with other molecules such as lipoproteins, in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them.
has related synonym: blood TC level

blood high density lipoprotein cholesterol level
type: Class
subclass of: blood lipoprotein cholesterol level
imported from: cmo.owl
def: Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in high-density lipoprotein (HDL) molecules in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. HDL is the smallest of the major lipoprotein particles, complex molecules that consist of a protein membrane surrounding a core of lipids. The HDL class of lipoproteins, specifically the subtypes of HDL2 and HDL3, have densities between 1.063 and 1.210 g/ml.
has related synonym: blood HDL level
has related synonym: blood HDL-C
comment: Values for density ranges of the lipoprotein classes are approximate. The classes may be defined differently by different researchers, in part because class definitions depend on the number of subclasses into which the lipoprotein fractions are divided.

blood low density lipoprotein cholesterol level
type: Class
subclass of: blood lipoprotein cholesterol level
imported from: cmo.owl
def: Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in low-density lipoprotein (LDL) molecules in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. LDL constitute a class of relatively large, heterogeneous lipoprotein particles, complex molecules that consist of a protein membrane surrounding a core of lipids. The LDL class of lipoproteins has a density between 1.019 and 1.063 g/ml. In some animal species, such as canine and rodents, this may overlap with the HDL1 class and be designated LDL/HDL1.
has related synonym: blood LDL level
has related synonym: blood LDL-C level
comment: Values for density ranges of the lipoprotein classes are approximate. The classes may be defined differently by different researchers, in part because class definitions depend on the number of subclasses into which the lipoprotein fractions are divided.

plasma total protein level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
def: Measurement of the total amount of all proteins, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, found in a specific volume of plasma, the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended.

blood electrolyte measurement
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: A quantification of one or more mineral salts found in the blood in the form of electrically charged ions.

blood enzyme activity level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
def: Any quantitation of the catalytic effect exerted by an enzyme in a specified sample of blood. An enzyme is a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reaction(s).
has related synonym: Not4Curation

organ morphological measurement
type: Class
subclass of: body morphological measurement
subclass of: organ measurement
imported from: cmo.owl
def: A measurement of the physical form and structure of an organ.
comment: This is the term which used to be just "organ measurement". Since it was under body morphological measurement, it clearly referred to a morphological measurement. Because a term for organ measurement was needed that was not morphological, and since this one already had annotations, I changed the term while keeping the ID and location in the ontology the same. JRS 2-15-2012.

heart wet weight
type: Class
subclass of: heart weight
imported from: cmo.owl
def: The weight of the heart after removal from the body but without desiccation.

heart dry weight
type: Class
subclass of: heart weight
imported from: cmo.owl
def: The weight of the heart after desiccation.

heart left ventricle wet weight
type: Class
subclass of: heart wet weight
subclass of: heart left ventricle weight
imported from: cmo.owl
def: The weight of the lower left chamber of the heart, which pumps oxygenated blood through the aorta into the systemic arteries, after removal from the body and separation from the rest of the heart but without desiccation.
has alternative id: CMO_0000655

heart right ventricle wet weight
type: Class
subclass of: heart wet weight
subclass of: heart right ventricle weight
imported from: cmo.owl
def: The weight of the lower right chamber of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, after removal from the body and separation from the rest of the heart but without desiccation.
has alternative id: CMO_0000624

calculated heart weight
type: Class
subclass of: heart weight
imported from: cmo.owl

heart weight to body weight ratio
type: Class
subclass of: calculated heart weight
imported from: cmo.owl
def: A calculated value in which the weight of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system, is divided by the total weight of the body, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism.

heart weight as percentage of body weight
type: Class
subclass of: calculated heart weight
imported from: cmo.owl
def: A calculated value in which the weight of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system, is presented as percentage of the total weight of the body, thus normalizing it to body weight.

aorta weight
type: Class
subclass of: aorta morphological measurement
imported from: cmo.owl
def: The weight of the aorta, the main trunk from which the arterial system proceeds. Weight is the heaviness or degree to which a body is drawn to the earth by gravity.

blood vessel measurement
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
def: Any quantification of a morphological or physiological parameter of one or more blood vessels, the network of muscular tubes that carry blood through the body.

renal/urinary measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl

kidney weight
type: Class
subclass of: kidney morphological measurement
imported from: cmo.owl
def: The weight of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

right kidney wet weight
type: Class
subclass of: single kidney wet weight
imported from: cmo.owl
def: The weight of the right kidney, the organ which lies on the right side of the body from the perspective of the subject and functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

left kidney wet weight
type: Class
subclass of: single kidney wet weight
imported from: cmo.owl
def: The weight of the left kidney, the organ which lies on the left side of the body from the perspective of the subject and functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

single kidney wet weight
type: Class
subclass of: kidney wet weight
imported from: cmo.owl
def: The weight of a single kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.
has exact synonym: individual kidney wet weight

both kidneys wet weight
type: Class
subclass of: kidney wet weight
imported from: cmo.owl
def: The weight of both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

kidney morphological measurement
type: Class
subclass of: organ morphological measurement
subclass of: kidney measurement
imported from: cmo.owl
def: Measurement of the physical form or structure of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

heart right ventricle weight to left ventricle weight ratio
type: Class
subclass of: calculated heart left ventricle weight
subclass of: calculated heart right ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T08:17:35Z
def: A calculated value which compares the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, with the weight of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, and presents it as a ratio.

blood granulocyte count
type: Class
subclass of: blood differential white blood cell count
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T08:22:51Z
def: The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter.

blood lipoprotein level
type: Class
subclass of: blood lipoprotein measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T10:21:58Z
def: The amount of lipoproteins, any of a group of conjugated proteins that have at least one lipid component, in a specific volume of blood.

urine creatinine level
type: Class
subclass of: urine measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T11:00:47Z
def: Measurement of the amount of creatinine in a specified sample of urine, the fluid waste product excreted by the kidneys. Creatinine is a nitrogenous compound formed in muscle as the end product of creatine metabolism. Blood and urine tests for creatinine are used as diagnostic indicators of kidney function and muscle mass.
xref: CHEBI_16737

muscle morphological measurement
type: Class
subclass of: body morphological measurement
subclass of: muscle measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-24T01:24:08Z
def: Any measurement of the physical form or structure of the skeletal, smooth and/or heart muscles of the body.

urine albumin level
type: Class
subclass of: urine protein level
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T11:01:46Z
def: The amount of albumin in a specified volume of urine. Urine albumin levels which are above normal but not detectable with routine protein testing are referred to as microalbuminuria.
has related synonym: urine microalbumin level

both kidneys wet weight as percentage of body weight
type: Class
subclass of: both kidneys wet weight
subclass of: calculated both kidneys weight
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-17T01:48:45Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a percentage, thus normalizing it to body weight.

calculated kidney weight
type: Class
subclass of: kidney weight
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-25T04:01:05Z
def: Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the weight of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has related synonym: Not4Curation

kidney wet weight
type: Class
subclass of: kidney weight
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-25T04:11:18Z
def: The weight of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

kidney dry weight
type: Class
subclass of: kidney weight
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-25T04:11:36Z
def: The weight after desiccation of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

blood vessel diameter
type: Class
subclass of: blood vessel morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:05:26Z
def: The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at either the inner surface or outer surface of the blood vessel wall.

ejection fraction
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:06:25Z
def: Percentage of blood pumped out of the left ventricle with each heart beat.
has related synonym: heart left ventricle ejection fraction

end-systolic volume
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:08:28Z
def: Volume of blood left in a ventricle at end of contraction.

circulation measurement
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:38:29Z
def: Any measurement of the movement of blood through the heart and blood vessels.
has related synonym: blood flow measurement

blood flow rate
type: Class
subclass of: circulation measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:38:42Z
def: The volume of blood flowing through a vessel or organ per unit of time.

cardiac output measurement
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:51:29Z
def: The volume of blood pumped from the right or left ventricle per minute, also used to calculate - stroke volume X heart rate.

arterial blood flow rate
type: Class
subclass of: blood flow rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:56:23Z
def: The volume of blood flowing through an artery per unit time.

venous blood flow rate
type: Class
subclass of: blood flow rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:56:38Z
def: The volume of blood passing through a vein per unit time.

vessel shear stress measurement
type: Class
subclass of: circulation measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T10:04:04Z
def: Movement of blood along the solid wall of a vessel, often represented by the Hagen-Poiseuille equation.

in vitro vessel shear stress
type: Class
subclass of: vessel shear stress measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T10:51:43Z

in vivo vessel shear stress
type: Class
subclass of: vessel shear stress measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T10:52:06Z

activated partial thromboplastin time
type: Class
subclass of: blood measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T11:20:31Z
def: The time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent. It is used to evaluate the intrinsic clotting system.

blood vessel dilation measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:02:16Z
has related synonym: vasodilation measurement

lumen diameter at maximum dilation expressed as percent of baseline
type: Class
subclass of: blood vessel dilation measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:02:34Z

blood vessel constriction measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:34:30Z
has related synonym: vasoconstriction measurement

lumen diameter at maximum constriction expressed as percent of baseline
type: Class
subclass of: blood vessel constriction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:35:20Z

systemic vascular resistance (SVR)
type: Class
subclass of: circulation measurement
subclass of: blood vessel resistance measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:41:52Z
def: Resistance to blood flow by blood vessels throughout the body, the degree to which the blood vessels impede the flow of blood, often calculated as SVR equal to the difference between mean arterial blood pressure(MAP) and central venous pressure(CVP) divided by cardiac output(CO).

end-diastolic volume
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T03:56:38Z
def: Volume of blood in ventricle immediately before a contraction.

stroke volume
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-11T01:32:10Z
def: Volume of blood pumped from one ventricle of the heart with each beat, calculated by subtracting the volume of blood in the ventricle at the end of a beat (end-systolic volume) from the volume of blood just prior to the beat (end-diastolic volume).

cell measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:30:36Z
def: Any quantification of a morphological or physiological parameter of one or more cells. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.

cardiomyocyte count
type: Class
subclass of: heart morphological measurement
subclass of: cell measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:30:50Z
def: Number of cells of muscular tissue in the heart in a specified sample size.

blood vessel endothelial cell count
type: Class
subclass of: blood vessel endothelium measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:33:11Z
def: The enumeration, i.e. measurement of the total number, of the specialized liner cells that form an interface between the circulating blood and the rest of the vessel wall in a specified sample of blood vessel, any one of the network of muscular tubes that carry blood through the body.
has exact synonym: blood vessel endothelial cell number
has exact synonym: vascular endothelial cell count

heart electrical conduction measurement
type: Class
subclass of: heart measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:36:15Z
def: Any measurement of components of the Electrical conduction system of the heart.The electrical conduction system of the heart transmits signals generated usually by the sinoatrial node to cause contraction of the heart muscle.

RR interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:39:30Z
def: Interval between an R wave and the next R wave of successive heart beats, inverse of the heart rate.
has related synonym: RR_Interval

PR interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:40:52Z
def: Time between the beginning of the P wave to the beginning of the QRS complex, reflects the time the electrical impulse takes to travel from the sinus node through the AVE node and entering the ventricles, used as an estimate of AV node function.
has related synonym: PR_Interval

ST interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:43:21Z
def: The time between the J point ( the point at which the QRS complex finishes and the ST segment begins) to the end of the T wave.
has related synonym: ST_Interval

QT interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:45:44Z
def: An interval measured from the onset of the QRS wave complex to the offset of the T wave.
has related synonym: QT_Interval

heart wall thickness
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:53:08Z

aorta wall thickness
type: Class
subclass of: artery wall thickness
subclass of: aorta wall morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:54:17Z
def: The depth of the wall of the aorta, the main trunk from which the arterial system proceeds.
has exact synonym: aortic wall thickness

heart posterior wall thickness
type: Class
subclass of: heart wall thickness
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T11:13:15Z
def: The thickness or depth of the dorsal/posterior wall of the heart. The dorsal wall is the portion of the heart muscle which is closest to the spine and farthest from the chest wall of the organism.
has related synonym: heart dorsal wall thickness

heart left ventricle posterior wall thickness
type: Class
subclass of: heart posterior wall thickness
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T11:15:28Z
def: The thickness or depth (i.e. the measurement of the two-dimensional extent of the distance between the inner and outer surfaces) of the dorsal/posterior wall of the left ventricle of the heart. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.
has related synonym: heart left ventricle dorsal wall thickness
comment: Note that "left" in this context refers to the perspective of the organism, not that of the observer.

heart right ventricle posterior wall thickness
type: Class
subclass of: heart posterior wall thickness
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T11:15:42Z
def: The thickness or depth of the dorsal/posterior wall of the right ventricle of the heart. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism.
has related synonym: heart right ventricle dorsal wall thickness

urine measurement
type: Class
subclass of: renal/urinary measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:26:05Z
def: Any measurement of urine, the fluid waste product excreted by the kidneys, or its components.

urine specific gravity
type: Class
subclass of: urine measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:27:01Z
def: Measure of the concentration of particles in the urine.
has related synonym: urine density

P wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:38:44Z
def: The magnitude of the P wave, the initial deflection of the cardiac cycle representing excitation of the atria as presented in an electrocardiogram.

P wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:39:11Z
def: The time from start to finish of the P wave , in the electrocardiograph illustrating the initial deflection of the cardiac cycle, representing the excitation of the atria.

Q wave depth
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:39:35Z
def: The distance to the lowest part of the Q wave which shows the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by electrocardiograph.

Q wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:39:55Z
def: The time from start to finish of the Q wave which illustrates the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by an electrocardiograph.

QRS duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:40:13Z
def: The time from start to finish of the QRS interval as calculated from a set of measurements taken from the beginning of the QRS complex to the end of the QRS complex representing the time it takes for ventricles to depolarize.

QRS amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:40:30Z
def: The magnitude of the portion of the electrocardiograph comprising the Q, R, and S waves which together represent ventricular depolarization.

QTC interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:40:52Z
def: QT interval corrected for heart rate calculated by the QT interval divided by the square root of the interval from one QRS complex to the onset of the next QRS complex measured in seconds.

R wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:41:09Z
def: The magnitude of the R wave, which is the initial upward deflection of the QRS complex following the Q wave representing early depolarization of the ventricles as illustrated by an electrocardiograph.

R wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:41:26Z
def: The time from start to finish of the R wave, the initial upward deflection of the QRS complex following the Q wave which represents early depolarization of the ventricles as illustrated in and electrocardiograph.

S wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:41:54Z
def: The magnitude of the S wave, the downward deflection of the QRS complex following the R wave representing late depolarization of the ventricles as illustrated in an electrocardiograph.

S wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:42:07Z
def: The time from start to finish of the S wave which is the downward deflection of the QRS complex following the R wave representing late depolarization as illustrated by an electrocardiograph.

ST amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:42:27Z

ST slope
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:42:46Z

ST wave displacement
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:43:04Z

T wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:43:21Z
def: The magnitude of the T wave, the deflection following the QRS complex representing repolarization of the ventricles as illustrated by and electrocardiograph.

PP interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T03:09:47Z
def: An interval measured from the onset of the P wave in one PQRST wave complex to the onset of the P wave in the following PQRST wave complex.
has related synonym: PP_Interval

pulse pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-25T01:54:10Z
def: The difference between systolic and diastolic blood pressures, i.e. the difference between the maximal arterial pressure and minimal arterial pressure during the cardiac cycle.

pulse
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-08-04T10:37:40Z
def: The count of the rhythmic contractions and expansions of an artery due to the surge of blood from the beat of the heart.

heart atrium morphological measurement
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:15Z
def: Measurement of the physical form or structure of either the right or the left upper chamber of the heart that receives blood from the veins and forces it into a ventricle.

left atrium weight
type: Class
subclass of: heart left atrium morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:28Z
def: The weight of the left atrium of the heart, the upper chamber on the left which empties into the lower chamber. Weight is the heaviness or degree to which a body is drawn toward the earth by gravity.

right atrium weight
type: Class
subclass of: heart right atrium morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:45Z
def: The weight of the right atrium, the upper right chamber of the heart which empties into the lower right chamber, i.e. the right ventricle. Weight is the heaviness or degree to which a body is drawn to the earth by gravity.

left atrium volume
type: Class
subclass of: heart left atrium morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:56Z
def: A measure of the capacity of the left heart atrium, the upper left chamber which empties into the lower heart chamber.

right atrium volume
type: Class
subclass of: heart right atrium morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:31:06Z
def: A measure of the three dimensional capacity of the right atrium of the heart, the upper right chamber which empties into the lower right chamber, i.e. the right ventricle.

heart ventricle morphological measurement
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:31:46Z
def: Any measurement of the physical form or structure of one or both ventricles of the heart, that is, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body.

both kidneys wet weight to body weight ratio
type: Class
subclass of: both kidneys wet weight
subclass of: calculated both kidneys weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-09-21T01:41:55Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a ratio, fraction or quotient, thus normalizing it to body weight.

serum triglyceride level
type: Class
subclass of: blood lipid measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-11-12T09:44:31Z
def: The amount of triglycerides in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Triglycerides are any of a group of lipids that are esters formed from one molecule of glycerol and three molecules of one or more fatty acids, are widespread in adipose tissue, and commonly circulate in the blood in the form of lipoproteins.

serum total cholesterol level
type: Class
subclass of: blood total cholesterol level
subclass of: serum cholesterol level
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-11-12T09:46:59Z
def: Measurement of the entire amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, without taking into account any association with other molecules such as lipoproteins, in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed.
has related synonym: serum TC level

blood differential white blood cell count
type: Class
subclass of: white blood cell count
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:24:28Z
def: The number of each type of leukocyte present in a specific volume of blood, usually 1 cubic millimeter.
has exact synonym: blood differential leukocyte count
has related synonym: blood differential WBC count

blood granulocyte count to total leukocyte count ratio
type: Class
subclass of: blood granulocyte count
subclass of: blood differential leukocyte count to total leukocyte count ratio
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:35:10Z
def: A calculated measurement in which the number of all granulocytes (regardless of type) in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
has related synonym: granulocyte count as percentage of total white blood cells
has related synonym: granulocyte count to total WBC count ratio
has related synonym: granulocyte count to total white blood cell count ratio
has related synonym: granulocyte percentage

blood eosinophil count to total leukocyte count ratio
type: Class
subclass of: blood granulocyte count
subclass of: blood granulocyte count to total leukocyte count ratio
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:38:12Z
def: A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. An eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes.
has related synonym: eosinophil count as percentage of total white blood cells
has related synonym: eosinophil count to total WBC count ratio
has related synonym: eosinophil granulocyte percentage
has related synonym: eosinophil percentage

blood neutrophil count to total leukocyte count ratio
type: Class
subclass of: blood granulocyte count
subclass of: blood granulocyte count to total leukocyte count ratio
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:39:37Z
def: A calculated measurement in which the number of neutrophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes.
has exact synonym: neutrophil granulocyte percentage
has related synonym: neutrophil count as percentage of total white blood cells
has related synonym: neutrophil count to total WBC count ratio
has related synonym: neutrophil percentage
has related synonym: polymorphonuclear cell percentage

blood lymphocyte count to total leukocyte count ratio
type: Class
subclass of: blood mononuclear cell count
subclass of: blood differential leukocyte count to total leukocyte count ratio
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:45:39Z
def: A calculated measurement in which the number of lymphocytes in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
has related synonym: lymphocyte count as percentage of total white blood cells
has related synonym: lymphocyte count to total WBC count ratio
has related synonym: lymphocyte percentage

total serum bilirubin level
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T11:30:05Z
def: The complete or entire amount of bilirubin in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Bilirubin is the bile pigment produced by breakdown of heme and reduction of biliverdin.

serum bicarbonate level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T12:01:33Z
def: The amount of carbonic acid dissolved in carbon dioxide and carbonate ion found in a specified volume of serum.

serum chloride level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T12:06:48Z
def: The amount of chloride ions found in a specified volume of serum.

blood glomerular filtration rate
type: Class
subclass of: blood chemistry measurement
subclass of: kidney measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:41:58Z
def: An estimation of the volume of blood filtered from the kidney glomerular capillaries into the Bowman's capsule per specified unit of time based on serum creatinine level, wieght and age of organism and other factors.

blood glomerular filtration rate, Diet in Renal Disease Formula (MDRD)
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:48:14Z

blood glomerular filtration rate, Chronic Kidney Disease Epidemiology Collaboration formula (CKE-EPI)
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:48:55Z
def: A calculated measurement which estimates the glomerular filtration rate (GFR), that is, the volume of fluid filtered from the renal capillaries per unit time, based on the serum creatinine level and adjusted for gender.

blood glomerular filtration rate, May Quadratic formula
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:50:15Z

blood glomerular filtration rate, Schwartz formula
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:50:43Z

serum potassium level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:52:02Z
def: Amount of potassium ions in a specified volume of serum.

serum sodium level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:56:30Z
def: The amount of sodium ions in a specified volume of serum.

serum calcium level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T03:15:06Z
def: The amount of calcium ions in a specified volume of serum.

pulmonary arterial diastolic blood pressure
type: Class
subclass of: diastolic blood pressure
subclass of: pulmonary arterial blood pressure measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-21T08:57:36Z
def: Blood pressure measured in the pulmonary artery during diastole, that is, during dilation or relaxation of the heart ventricles.

pulmonary arterial systolic blood pressure
type: Class
subclass of: systolic blood pressure
subclass of: pulmonary arterial blood pressure measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-21T08:58:00Z
def: Blood pressure measured in the pulmonary artery during systole, that is, during contraction of the heart ventricles.

heart left ventricle weight to body weight ratio
type: Class
subclass of: calculated heart left ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-21T09:42:17Z
def: A calculated value in which the weight of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, is divided by the total weight of the body and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and by extension to the size of the organism.
has alternative id: CMO_0000540
has exact synonym: heart left ventricle weight as a percentage of body weight
has related synonym: LV mass/BW

absolute change in mean arterial blood pressure
type: Class
subclass of: mean arterial blood pressure
subclass of: change in calculated blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:24:16Z
def: The difference in mean arterial blood pressure between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

absolute change in heart rate
type: Class
subclass of: calculated heart rate measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:25:37Z
def: Absolute difference in heart rate between two points in time or two conditions.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

glomerulus count
type: Class
subclass of: kidney morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:29:17Z
def: The number of glomeruli in all or part of a kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.
has exact synonym: glomeruli count

heart left ventricle dry weight
type: Class
subclass of: heart left ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:33:14Z

serum phosphate level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T02:44:01Z
def: The amount of phosphorus, measured as inorganic phosphate, in a specified sample of serum.
has related synonym: serum inorganic phosphate level
has related synonym: serum inorganic phosphorus level
has related synonym: serum phosphorus level

serum glucose level
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T02:45:05Z
def: Measurement of the amount of glucose, the monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues which is one of the three dietary monosaccharides that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms, in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed.

serum albumin level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T02:48:13Z
def: The amount of albumin in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed.

serum alanine aminotransferase activity level
type: Class
subclass of: blood enzyme activity level
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T04:10:11Z
def: The amount of ezymatic activity of glutamic-pyruvate transaminase enzyme, commonly known as alanine transaminase or alanine aminotransferase (ALT), enzyme in a specified sample of serum. ALT catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Serum ALT level is used as an enzymatic marker for liver disease or damage.
has exact synonym: serum alanine transaminase activity level
has exact synonym: serum glutamic-pyruvate transaminase activity level
has related synonym: serum ALT activity level
has related synonym: serum GPT activity level

serum alkaline phosphatase activity level
type: Class
subclass of: blood enzyme activity level
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T04:11:05Z
def: Quantitation of the catalytic effect exerted by alkaline phosphatase (AP) in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. AP is an enzyme that catalyzes the cleavage of orthophosphate from orthophosphoric monoesters under alkaline conditions.

serum aspartate aminotransferase activity level
type: Class
subclass of: blood enzyme activity level
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T04:18:08Z
def: The amount of enzymatic activity of glutamic-oxaloacetic transaminase enzyme, commonly known as aspartate transaminase or aspartate aminotransferase (AST), in a specified sample of serum. AST catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid. Serum AST level is used as an enzymatic marker for liver disease or damage.
has exact synonym: serum aspartate transaminase activity level
has exact synonym: serum glutamic-oxaloacetic transaminase activity level
has related synonym: SGOT activity level
has related synonym: serum AST activity level
has related synonym: serum GOT activity level

urine protein level
type: Class
subclass of: urine measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T01:45:21Z

left ventricular end-systolic blood pressure
type: Class
subclass of: left ventricular systolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:34:53Z
def: Measurement of the pressure within the heart left ventricle at the end of systole, the period of contraction of the heart when the blood is forced from the ventricles into the pulmonary artery (right ventricle) and the aorta (left ventricle).

left ventricular end-diastolic blood pressure
type: Class
subclass of: left ventricular diastolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:35:59Z
def: The pressure in the heart left ventricle at the end of diastole, the period when the heart is in a state of relaxation and expansion and the ventricles fill with blood.

absolute change in systolic blood pressure
type: Class
subclass of: change in systolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:36:40Z
def: Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

absolute change in diastolic blood pressure
type: Class
subclass of: change in diastolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:36:56Z
def: Calculated measurement of a difference in diastolic blood pressure between two points or two conditions expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

single kidney wet weight to body weight ratio
type: Class
subclass of: single kidney wet weight
subclass of: calculated single kidney weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:50:38Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of a single kidney, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a ratio, fraction or quotient, thus normalizing it to body weight.
has exact synonym: individual kidney wet weight to body weight ratio

single kidney wet weight as percentage of body weight
type: Class
subclass of: single kidney wet weight
subclass of: calculated single kidney weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:50:52Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of a single kidney, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a percentage, thus normalizing it to body weight.
has exact synonym: individual kidney wet weight as percentage of body weight

heart right ventricle dry weight
type: Class
subclass of: heart right ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-04T12:57:25Z

heart contraction measurement
type: Class
subclass of: heart measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:39:00Z
def: Any measurement of components of the periodic tightening and loosening of the heart muscle.
has related synonym: heart contractility measurement

time to onset of heart contraction
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:42:05Z
def: Measure of the time from the relaxation of the heart muscle to the beginning of the tightening of the heart muscle during contraction.

time to peak heart contraction
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:48:18Z
def: Measurement of the time from the beginning of heart muscle contraction to the maximum contracted state.

heart contraction pressure
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:56:51Z
def: Pressure exerted by the heart muscle in its maximally contracted state.

organ measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:00:53Z
def: Any measurement of a structural part of a system of the body that is composed of tissues and cells that enable it to perform a particular function.

heart measurement
type: Class
subclass of: cardiovascular measurement
subclass of: organ measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:06:19Z
comment: This is not the same term as the original "heart measurement". That term is now "heart morphological measurement".

heart effluent measurement
type: Class
subclass of: organ measurement
subclass of: heart measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:11:39Z
def: A measurement made on a fluid flowing out of the heart.

heart effluent volume
type: Class
subclass of: heart effluent measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:14:44Z
def: The volume of a fluid flowing out of the heart.

timed heart effluent volume
type: Class
subclass of: heart effluent volume
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:16:22Z
def: The volume of a fluid flowing out of the heart during a specified amount of time.

heart effluent enzyme level
type: Class
subclass of: heart effluent measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:21:20Z
def: The amount of an enzyme in a specified volume of fluid flowing out of the heart.

heart effluent lactate dehydrogenase activity level
type: Class
subclass of: heart effluent enzyme level
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:25:02Z
def: The amount of lactate dehydrogenase activity measured in a specified volume of fluid flowing out of the heart.
has exact synonym: heart effluent LDH activity level

organ lesion measurement
type: Class
subclass of: organ measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:45:18Z
def: Measurement of a lesion in an organ. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.
has related synonym: tissue damage measurement

heart lesion measurement
type: Class
subclass of: heart measurement
subclass of: organ lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:48:03Z
def: A measurement of any lesion of the heart. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.

infarction measurement
type: Class
subclass of: organ non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:50:09Z
def: Measurement of an area of necrotic tissue resulting from a reduction or obstruction of the oxygen supplied to that tissue.

heart infarction measurement
type: Class
subclass of: infarction measurement
subclass of: heart non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:58:36Z
def: Measurement of an area of necrotic tissue in the heart resulting from a reduction or obstruction of the oxygen supply.
has related synonym: myocardial infarction measurement

heart left ventricle infarction measurement
type: Class
subclass of: heart infarction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:09:00Z
def: Measurement of an area of necrotic tissue in the left ventricle of the heart resulting from a reduction or obstruction of the oxygen supply to the heart.

infarction size
type: Class
subclass of: infarction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:11:07Z
def: Measurement of the area, volume or weight of necrotic tissue resulting from a reduction or obstruction of the oxygen supplied to that tissue.

heart infarction size
type: Class
subclass of: heart infarction measurement
subclass of: infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:14:35Z
def: Measurement of the area, volume or weight of necrotic tissue in the heart resulting from a reduction or obstruction of the oxygen supply to the heart.

heart left ventricle infarction size
type: Class
subclass of: heart left ventricle infarction measurement
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:18:51Z
def: Measurement of the area, volume or weight of necrotic tissue in the heart left ventricle resulting from a reduction or obstruction of the oxygen supply to the heart.

calculated heart left ventricle infarction size
type: Class
subclass of: heart left ventricle infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:27:35Z

heart left ventricle infarction size as percentage of total heart left ventricle size
type: Class
subclass of: calculated heart left ventricle infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:28:08Z

heart ventricle weight
type: Class
subclass of: heart weight
subclass of: heart ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:46:40Z
def: The heaviness of one or both ventricles of the heart, that is, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body, or the degree to which one or both ventricles of the heart are drawn toward the earth by gravity.

heart infarction weight
type: Class
subclass of: heart weight
subclass of: infarction size
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T02:50:48Z

heart infarction area
type: Class
subclass of: infarction size
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:02:09Z

heart left ventricle infarction weight
type: Class
subclass of: heart left ventricle infarction size
subclass of: heart infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:02:46Z

heart left ventricle infarction area
type: Class
subclass of: heart left ventricle infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:03:35Z

calculated heart left ventricle infarction area
type: Class
subclass of: heart left ventricle infarction area
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:04:15Z

calculated heart left ventricle infarction weight
type: Class
subclass of: calculated heart left ventricle infarction size
subclass of: heart left ventricle infarction weight
subclass of: calculated heart infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:04:51Z

heart left ventricle infarction weight as percentage of total heart left ventricle weight
type: Class
subclass of: heart left ventricle infarction size as percentage of total heart left ventricle size
subclass of: calculated heart left ventricle infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:05:44Z

calculated heart infarction weight
type: Class
subclass of: heart infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:08:57Z

absolute change in body temperature
type: Class
subclass of: body temperature
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T04:05:52Z
def: The difference in body temperature between two different points in time or between two different conditions.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

blood vessel resistance measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T05:24:30Z
def: Measurement of the amount of resistance in a blood vessel to the flow of blood or other fluid through it.

pulmonary vascular resistance (PVR)
type: Class
subclass of: blood vessel resistance measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T05:53:03Z
def: Resistance to blood flow by blood vessels in the lung.

calculated pulmonary vascular resistance
type: Class
subclass of: pulmonary vascular resistance (PVR)
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T05:57:02Z
def: Measurement of vascular resistance in lung blood vessels calculated from other indirect measurements.
has exact synonym: calculated PVR

calculated pulmonary vascular resistance normalized to body weight
type: Class
subclass of: calculated pulmonary vascular resistance
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T06:00:03Z
has narrow synonym: R_Flow100

blood vessel endothelium measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T12:26:02Z
def: Measurement made on the endothelial tissue or endothelial cells lining a blood vessel.

calculated blood vessel endothelium measurement
type: Class
subclass of: blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T12:29:04Z

FAPGG metabolism-surface area product
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T12:31:07Z

methylene blue metabolism-surface area product without auto-oxidation
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T01:02:07Z

methylene blue metabolism-surface area product after auto-oxidation
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T01:03:47Z

methylene blue to FAPGG metabolism-surface area product ratio
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T01:12:29Z
def: Ratio of the methylene blue metabolism-surface area product without auto-oxidation to the FAPGG metabolism-surface area product.

blood vessel contractile force measurement
type: Class
subclass of: blood vessel constriction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T04:15:39Z
def: Any measurement of the energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel.
has related synonym: blood vessel contractility measurement

blood vessel maximum contractile force
type: Class
subclass of: blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T04:46:14Z
def: Measurement of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel.
has related synonym: blood vessel maximum contractility measurement

maximum contractile force per wet weight of vessel
type: Class
subclass of: blood vessel maximum contractile force
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T04:47:52Z

chemical response/sensitivity measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:09:34Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to a drug or other chemical stimulus.

calculated blood vessel contractile force measurement
type: Class
subclass of: blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:16:11Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel.

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
type: Class
subclass of: phenylephrine response/sensitivity measurement
subclass of: concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50)
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:17:28Z
def: A calculated value for the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy.
has exact synonym: phenylephrine half maximal effective concentration (EC50)
xref: CHEBI 8093

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
type: Class
subclass of: phenylephrine response/sensitivity measurement
subclass of: logarithm of the concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (Log EC50)
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:17:54Z
def: A calculated value for logarithm of the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
has exact synonym: phenylephrine Log half maximal effective concentration (Log EC50)
xref: CHEBI 8093

calculated blood vessel dilation force reduction measurement
type: Class
subclass of: blood vessel dilation force reduction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:21:12Z
def: Measurement of the reduction in force during dilation of a blood vessel via calculations from direct measurements rather than expressing the direct measurements themselves.

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: acetylcholine response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:23:57Z
def: A calculated value for the concentration of acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of ACh is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during ACh-induced relaxation of the vessel wall (i.e. the maximum effect of Ach which is the minimum contractile energy).
has exact synonym: acetylcholine half maximal effective concentration (EC50)
xref: CHEBI_15355

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: acetylcholine response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:24:16Z
def: A calculated value for logarithm of the concentration of acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of ACh is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during ACh-induced relaxation of the vessel wall (i.e. the maximum effect of Ach which is the minimum contractile energy). The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
has exact synonym: acetylcholine Log half maximal effective concentration (Log EC50)
xref: CHEBI_15355

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: sodium nitroprusside response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:24:44Z
def: A calculated value for the concentration of sodium nitroprusside (SNP), the red-colored inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of SNP is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during SNP-induced relaxation of the vessel wall (i.e. the maximum effect of SNP which is the minimum contractile energy).
has exact synonym: sodium nitroprusside half maximal effective concentration (EC50)
xref: CHEBI_29321
xref: CHEBI 9179

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: sodium nitroprusside response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:25:16Z
def: A calculated value for logarithm of the concentration of sodium nitroprusside (SNP), the red-coloured inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of SNP is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during SNP-induced relaxation of the vessel wall (i.e. the maximum effect of SNP which is the minimum contractile energy).
has exact synonym: sodium nitroprusside Log half maximal effective concentration (Log EC50)
xref: CHEBI_29321
xref: CHEBI 9179

maximum contractile force per wet weight of aorta
type: Class
subclass of: maximum contractile force per wet weight of vessel
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:42:31Z

blood vessel dilation force reduction measurement
type: Class
subclass of: blood vessel dilation measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:48:29Z
def: Measurement of the reduction in force during blood vessel dilation.

blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:53:37Z

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: blood vessel dilation expressed as percent of force at maximum constriction
subclass of: acetylcholine response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:55:20Z
has related synonym: acetylcholine-induced blood vessel dilation expressed as percent of phenylephrine-induced vasoconstriction

sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: blood vessel dilation expressed as percent of force at maximum constriction
subclass of: sodium nitroprusside response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:59:59Z
has related synonym: sodium nitroprusside-induced blood vessel dilation expressed as percent of phenylephrine-induced vasoconstriction

hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: blood vessel dilation expressed as percent of force at maximum constriction
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:00:51Z

slope measurement of chemical-induced contraction
type: Class
subclass of: calculated blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:03:40Z
has narrow synonym: slope measurement of phenylephrine-induced contraction
has related synonym: slope measurement of drug-induced contraction

fast-slope measurement of chemical-induced contraction
type: Class
subclass of: slope measurement of chemical-induced contraction
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:05:49Z
has narrow synonym: fast-slope measurement of phenylephrine-induced contraction
has related synonym: fast-slope measurement of drug-induced contraction

slow-slope measurement of chemical-induced contraction
type: Class
subclass of: slope measurement of chemical-induced contraction
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:06:21Z
has narrow synonym: slow-slope measurement of phenylephrine-induced contraction
has related synonym: slow-slope measurement of drug-induced contraction

acetylcholine response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:11:24Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter.
xref: CHEBI_15355

phenylephrine response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:12:47Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor.
xref: CHEBI 8093

sodium nitroprusside response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:13:21Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to sodium nitroprusside (SNP), the red-colored inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator.
xref: CHEBI_29321

percent change in heart rate
type: Class
subclass of: calculated heart rate measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:21:00Z

change in calculated blood pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:31:30Z
def: Calculation of a difference between representations of blood pressure in a treated versus untreated state or over time, after the original values have been normalized or adjusted by a mathematical process or computation. Blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood.

change in developed blood pressure
type: Class
subclass of: developed blood pressure
subclass of: change in calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:31:52Z
def: A calculated measurement of the difference in developed blood pressure between a treated state and a control state. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

percent change in developed blood pressure
type: Class
subclass of: change in developed blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:32:19Z
def: A calculated measurement of the difference in developed blood pressure between a treated state and a control state, expressed as a percentage. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

change in systolic blood pressure
type: Class
subclass of: systolic blood pressure
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:34:31Z
def: Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions.

percent change in systolic blood pressure
type: Class
subclass of: change in systolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:35:00Z
def: The relative difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions expressed as a percentage.

change in arterial blood flow rate
type: Class
subclass of: arterial blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:37:30Z

percent change in arterial blood flow rate
type: Class
subclass of: change in arterial blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:38:02Z

absolute change in arterial blood flow rate
type: Class
subclass of: change in arterial blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:38:35Z
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

percent change in left ventricular developed pressure
type: Class
subclass of: percent change in developed blood pressure
subclass of: change in left ventricular developed pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:08:08Z
def: A calculated measurement of the difference in developed pressure measured in the heart left ventricle between a treated state and a control state, expressed as a percentage. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

change in left ventricular developed pressure
type: Class
subclass of: left ventricular developed pressure
subclass of: change in developed blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:09:30Z
def: A calculated measurement of the difference in developed pressure measured in the heart left ventricle between a treated state and a control state. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

change in left ventricular systolic blood pressure
type: Class
subclass of: left ventricular systolic blood pressure
subclass of: change in systolic blood pressure
subclass of: calculated left ventricular blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:13:41Z
def: Difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions.

percent change in left ventricular systolic blood pressure
type: Class
subclass of: percent change in systolic blood pressure
subclass of: change in left ventricular systolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:14:31Z
def: The relative difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions expressed as a percentage.

heart effluent lactate dehydrogenase activity level normalized to heart weight
type: Class
subclass of: heart effluent lactate dehydrogenase activity level
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-30T07:52:39Z
def: The activity level of LDH in effluent expressed relative to the weight of the heart; calculated as LDH activity divided by heart wet weight.

heart left ventricle weight
type: Class
subclass of: heart ventricle weight
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T11:37:18Z

heart right ventricle weight
type: Class
subclass of: heart ventricle weight
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T11:38:49Z

mean pulmonary arterial blood pressure
type: Class
subclass of: mean arterial blood pressure
subclass of: pulmonary arterial blood pressure measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T12:01:20Z
def: The average blood pressure within the pulmonary artery over a specified period of time, or technically over a complete cycle of one heartbeat.
has related synonym: mean pulmonary artery (PA) pressure

pulmonary arterial blood pressure measurement
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T02:24:23Z
def: Measurement of blood pressure in the pulmonary artery.
has related synonym: pulmonary artery (PA) blood pressure measurement
has related synonym: pulmonary artery pressure

organ tumorous lesion measurement
type: Class
subclass of: organ lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T11:34:46Z
def: Measurement of an organ lesion which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells.

organ non-tumorous lesion measurement
type: Class
subclass of: organ lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T11:46:40Z
def: Measurement of an organ lesion which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc.

heart non-tumorous lesion measurement
type: Class
subclass of: heart lesion measurement
subclass of: organ non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T12:53:39Z
def: Measurement of a heart lesion which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc.

heart tumorous lesion measurement
type: Class
subclass of: heart lesion measurement
subclass of: organ tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T01:22:44Z
def: Measurement of a lesion of the heart which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells.

kidney measurement
type: Class
subclass of: renal/urinary measurement
subclass of: organ measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:34:14Z
def: Any measurement, morphological or physiological, involving the kidney or any part thereof.
has related synonym: Not4Curation

renal blood flow rate
type: Class
subclass of: blood flow rate
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:38:08Z
def: Renal blood flow (RBF) is the volume of blood delivered to or exiting from the kidneys per unit time.

renal arterial blood flow rate
type: Class
subclass of: arterial blood flow rate
subclass of: renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:44:48Z
def: Arterial renal blood flow (RBFa) is the volume of blood delivered to the kidneys per unit time via the renal arteries.

renal venous blood flow rate
type: Class
subclass of: venous blood flow rate
subclass of: renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:48:22Z
def: Venous renal blood flow (RBFv) is the volume of blood exiting from the kidneys per unit time via the renal veins.

heart right ventricle weight to body weight ratio
type: Class
subclass of: calculated heart right ventricle weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T12:08:49Z
def: A calculated value in which the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is divided by the total weight of the body and presented as a ratio thus normalizing it to body weight.

heart right ventricle weight as a percentage of body weight
type: Class
subclass of: calculated heart right ventricle weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T12:09:38Z
def: A calculated value in which the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is presented as percentage of the total weight of the body thus normalizing it to body weight.

heart left ventricle morphological measurement
type: Class
subclass of: heart ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-18T04:24:26Z
def: Any measurement of the physical form or structure of the left ventricle of the heart. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.
comment: Note, "left" in this context refers to the perspective of the organism, not that of the nobserver.

heart right ventricle morphological measurement
type: Class
subclass of: heart ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-18T04:30:51Z
def: Any measurement of the physical form or structure of the right ventricle of the heart. The right ventricle is the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung.

blood vessel lesion measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T10:04:12Z
def: Measurement of a localized pathological change in structure of a blood vessel due to injury or disease; especially one that is circumscribed and well defined.

calculated blood vessel diameter measurement
type: Class
subclass of: blood vessel diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:15:46Z
def: A measurement of blood vessel diameter which has been normalized or adjusted by a mathematical process or computation.
has related synonym: Not4Curation

blood vessel wall thickness
type: Class
subclass of: blood vessel morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:18:48Z

calculated blood vessel wall thickness measurement
type: Class
subclass of: blood vessel wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:20:54Z
def: A measurement of the depth of the wall of a blood vessel which has been normalized or adjusted by a mathematical process or computation.
has related synonym: Not4Curation

artery wall thickness
type: Class
subclass of: blood vessel wall thickness
subclass of: artery wall measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:23:13Z
def: A measurement of the depth of the wall of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues.

calculated artery wall thickness measurement
type: Class
subclass of: calculated blood vessel wall thickness measurement
subclass of: artery wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:27:42Z
def: A measurement of the depth of the wall of an artery which has been normalized or adjusted by a mathematical process or computation. An artery is one of the large blood vessels carrying blood in a direction away from the heart to the tissues.
has related synonym: Not4Curation

artery diameter
type: Class
subclass of: blood vessel diameter
subclass of: artery measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:32:00Z

blood vessel inner diameter
type: Class
subclass of: blood vessel diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:39:26Z
def: The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at the inner surface of the blood vessel wall.
has exact synonym: blood vessel lumen diameter

blood vessel outer diameter
type: Class
subclass of: blood vessel diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:41:25Z
def: The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at the outer surface of the blood vessel wall.

artery inner diameter
type: Class
subclass of: artery diameter
subclass of: blood vessel inner diameter
subclass of: artery lumen measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:43:00Z
def: The length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall.
has exact synonym: artery lumen diameter

artery outer diameter
type: Class
subclass of: artery diameter
subclass of: blood vessel outer diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:44:18Z
def: The length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the outer surface of the blood vessel wall.

calculated artery diameter measurement
type: Class
subclass of: calculated blood vessel diameter measurement
subclass of: artery diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:48:55Z
def: Measurement of the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at either the inner surface or outer surface of the blood vessel wall, which has been normalized or adjusted by a mathematical process or computation.
has related synonym: Not4Curation

artery measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:57:08Z
def: Any measurement of one of the large blood vessels carrying blood in a direction away from the heart to the tissues.

artery lesion measurement
type: Class
subclass of: blood vessel lesion measurement
subclass of: artery measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:59:52Z
def: Measurement of any localized pathological change in structure of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues, due to injury or disease; especially one that is circumscribed and well defined.

calculated artery lesion measurement
type: Class
subclass of: artery lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:04:57Z
def: Measurement which has been normalized or adjusted by a mathematical process or computation of any localized pathological change in structure of an artery due to injury or disease; especially one that is circumscribed and well defined.
has related synonym: Not4Curation

calculated blood vessel lesion measurement
type: Class
subclass of: blood vessel lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:13:01Z
def: Measurement which has been normalized or adjusted by a mathematical process or computation of any localized pathological change in structure of a blood vessel due to injury or disease; especially one that is circumscribed and well defined.
has related synonym: Not4Curation

blood vessel wall thickness to blood vessel inner diameter ratio
type: Class
subclass of: calculated blood vessel diameter measurement
subclass of: calculated blood vessel wall thickness measurement
subclass of: calculated blood vessel lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:14:51Z
def: A calculated measurement in which the ratio of the wall thickness (WT) of a blood vessel is divided by the inner diameter (ID) of that vessel at that location, and the result presented as a ratio, fraction, quotient or percentage, for example, WT/ID x 100. This measurement is often used to assess stenosis, a pathological narrowing of a blood vessel.
has exact synonym: blood vessel wall thickness as percentage of blood vessel lumen diameter
has related synonym: blood vessel stenosis measurement
has related synonym: blood vessel wall thickness as percentage of blood vessel inner diameter

artery wall thickness to artery inner diameter ratio
type: Class
subclass of: calculated artery wall thickness measurement
subclass of: calculated artery lesion measurement
subclass of: blood vessel wall thickness to blood vessel inner diameter ratio
subclass of: calculated artery inner diameter measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:16:51Z
def: Ratio of the wall thickness (WT) of an artery to inner diameter (ID) of that artery at that location, usually expressed as a percentage, i.e. WT/ID x 100, but could also be expressed as a ratio, fraction or quotient. This measurement can be used to assess stenosis, a pathological narrowing of a blood vessel.
has related synonym: arterial stenosis measurement
has related synonym: artery wall thickness as percentage of artery inner diameter
has related synonym: artery wall thickness as percentage of artery lumen diameter

calculated artery inner diameter measurement
type: Class
subclass of: artery inner diameter
subclass of: calculated artery diameter measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:25:16Z
def: A measurement of the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall, after that measurement has been normalized or adjusted by a mathematical process or computation. An artery is a blood vessel that carries blood away from the heart.
has related synonym: Not4Curation

ventricle contraction measurement
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T03:24:53Z
def: Any measurement of components of the periodic tightening and loosening of the muscles of a ventricle of the heart.

heart left ventricular end-diastolic diameter
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:14:05Z
def: The diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter.
has related synonym: LVDD
has related synonym: LVEDD
has related synonym: left ventricular end-diastolic dimension

heart left ventricle end-systolic diameter
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:32:16Z
def: The diameter across the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter.
has related synonym: LVESD
has related synonym: LVSD
has related synonym: left ventricular end-systolic dimension

calculated heart left ventricle morphological measurement
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:42:40Z
def: A measurement of the physical form or structure of the left ventricle of the heart which has been normalized or adjusted by a mathematical process or computation. The heart left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.

heart left ventricle fractional shortening
type: Class
subclass of: calculated heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:51:33Z
def: A calculated measurement corresponding to the ratio or percent reduction in left ventricular diameter between end-diastole and end-systole. Can be calculated as the left ventricle end-diastolic diameter (LVDd) minus the left ventricle end-systolic diameter (LVSd) divided by the left ventricle end-diastolic diameter (LVDd) with the quotient multiplied by 100, i.e. FS = [(LVDd-LVSd)/LVDd] x 100.

heart left ventricle anterior wall thickness
type: Class
subclass of: heart left ventricle morphological measurement
subclass of: heart anterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T04:11:09Z
def: The thickness or depth of the ventral/anterior wall of the left ventricle of the heart. The ventral/anterior wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism.
has related synonym: heart left ventricle ventral wall thickness

heart ventricle septal wall thickness
type: Class
subclass of: heart right ventricle posterior wall thickness
subclass of: heart left ventricle anterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T05:59:34Z
def: The thickness or depth of the septal wall of the heart ventricles. The septal wall is the portion of the heart left ventricle ventral/anterior wall and right ventricle dorsal/posterior wall which is shared between the ventricles.
has exact synonym: heart ventricle septal wall thickness
has related synonym: SWT
has related synonym: antero-septal wall thickness
has related synonym: heart interventricular septum thickness
has related synonym: heart intraventricular wall thickness
has related synonym: heart ventricle septum thickness

heart left ventricle relative wall thickness
type: Class
subclass of: calculated heart left ventricle morphological measurement
subclass of: heart ventricle relative wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T06:00:34Z
def: A calculated measurement of left ventricular geometry and is calculated by dividing the end-diastolic diameter into 2x the posterior wall thickness, 2x the septal wall thickness or the sum of the posterior and septal wall thicknesses. It represents a measure of the wall thickness normalized to the size of the ventricle lumen.

heart left ventricle end-diastolic relative wall thickness
type: Class
subclass of: heart left ventricle relative wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T06:15:29Z
def: A calculated measurement of left ventricular geometry and is calculated by dividing the end-diastolic diameter into 2x the posterior wall thickness at end-diastole, 2x the septal wall thickness at end-diastole or the sum of the posterior and septal wall thicknesses at end-diastole. It represents a measure of the wall thickness normalized to the size of the ventricle lumen.

heart anterior wall thickness
type: Class
subclass of: heart wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T10:15:23Z
def: The thickness or depth of the ventral/anterior wall of the heart. The ventral wall is the portion of the heart muscle which is farthest from the spine and closest to the chest wall of the organism.
has related synonym: heart ventral wall thickness

calculated heart wall thickness measurement
type: Class
subclass of: heart wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T10:31:58Z
has related synonym: Not4Curation

heart relative wall thickness
type: Class
subclass of: calculated heart wall thickness measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T11:04:28Z

heart ventricle relative wall thickness
type: Class
subclass of: heart relative wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T11:05:55Z

mean velocity of circumferential fiber shortening
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T01:25:59Z
def: The extent of shortening of the minor internal circumference (at the midpoint of the long axis) between end-diastole and end-systole, divided by the time required for shortening.
has exact synonym: mean circumferential fiber shortening rate
has related synonym: mean VCF

heart right ventricle anterior wall thickness
type: Class
subclass of: heart anterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T02:57:57Z
def: The thickness or depth of the ventral/anterior wall of the right ventricle of the heart. The ventral wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism.
has related synonym: heart right ventricle ventral wall thickness

superficial glomerulus count
type: Class
subclass of: glomerulus count
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-02T01:00:46Z
def: Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.
has exact synonym: superficial glomeruli count

count of superficial glomeruli directly contacting the kidney surface
type: Class
subclass of: superficial glomerulus count
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-02T01:14:28Z
def: Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis, and directly in contact with the surface of the kidney, i.e. the renal capsule. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.
has related synonym: surface glomeruli count

count of superficial glomeruli not directly contacting the kidney surface
type: Class
subclass of: superficial glomerulus count
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-02T01:15:32Z
def: Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis but without any direct contact with the surface of the kidney, i.e. the renal capsule. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.

heart infarction volume
type: Class
subclass of: infarction size
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-03T06:05:33Z

change in diastolic blood pressure
type: Class
subclass of: diastolic blood pressure
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-03T06:17:05Z
def: Measurement of any change or difference in the diastolic blood pressure between two points or two conditions. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.
has related synonym: Not4Curation

percent change in diastolic blood pressure
type: Class
subclass of: change in diastolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-03T06:19:27Z
def: The relative difference in the diastolic blood pressure between two points or two conditions, expressed as a percentage. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.

absolute change in left ventricular systolic blood pressure
type: Class
subclass of: change in left ventricular systolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-13T01:16:23Z
def: Calculated measurement of a difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

head temperature
type: Class
subclass of: body temperature
imported from: cmo.owl
created by: jsmith
creation date: 2012-08-23T03:27:50Z
def: Temperature measured at the surface of or within the head of an experimental subject. Because the temperature of the head/brain can influence neurological measurements, head temperature is or can be considered to be distinct from core body temperature.
has related synonym: cranial temperature

core body temperature
type: Class
subclass of: body temperature
imported from: cmo.owl
created by: jsmith
creation date: 2012-08-23T04:06:16Z
def: The temperature of the internal tissues and organs of the body.
has related synonym: core temperature

calculated heart left ventricle weight
type: Class
subclass of: calculated heart weight
subclass of: heart left ventricle weight
subclass of: calculated heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-09-13T06:09:33Z
def: A measurement which has been normalized or adjusted by a mathematical process or computation of the weight of the left ventricle of the heart, that is, its the heaviness or degree to which it is drawn toward the earth by gravity. The heart left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.

calculated heart right ventricle weight
type: Class
subclass of: calculated heart weight
subclass of: heart right ventricle weight
subclass of: calculated heart right ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-09-13T06:11:08Z

calculated heart right ventricle morphological measurement
type: Class
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-09-13T06:14:55Z

cerebral artery inner diameter
type: Class
subclass of: artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:31:53Z
def: The length of a line which crosses a transverse view of a cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The cerebral arteries are those which supply blood to the brain, more specifically, to the cerebrum.
has related synonym: cerebral artery lumen diameter

anterior cerebral artery inner diameter
type: Class
subclass of: cerebral artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:39:47Z
def: The length of a line which crosses a transverse view of an anterior cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The anterior cerebral artery (ACA) is one of a pair of arteries that supply oxygenated blood to the most medial portions of the frontal lobes and superior medial parietal lobes of the brain.
has related synonym: ACA inner diameter
has related synonym: anterior cerebral artery lumen diameter

middle cerebral artery inner diameter
type: Class
subclass of: cerebral artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:48:00Z
def: The length of a line which crosses a transverse view of a middle cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain.
has related synonym: MCA inner diameter
has related synonym: middle cerebral artery lumen diameter

posterior cerebral artery inner diameter
type: Class
subclass of: cerebral artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:59:18Z
def: The length of a line which crosses a transverse view of a posterior cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The posterior cerebral artery (PCA) is one of a pair of blood vessels that supply blood to the posterior aspect, i.e. the occipital lobe, of the brain.
has related synonym: PCA inner diameter
has related synonym: posterior cerebral artery lumen diameter

kidney lesion measurement
type: Class
subclass of: organ lesion measurement
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T02:59:36Z
def: Measurement of a lesion in kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.

kidney non-tumorous lesion measurement
type: Class
subclass of: organ non-tumorous lesion measurement
subclass of: kidney lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:01:39Z
def: Measurement of a lesion in the kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc.

kidney tumorous lesion measurement
type: Class
subclass of: organ tumorous lesion measurement
subclass of: kidney lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:03:01Z
def: Measurement of a lesion in the kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells.

kidney glomerulosclerotic lesion measurement
type: Class
subclass of: kidney fibrotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:09:04Z
def: Any measurement of lesions resulting from fibrosis, scarring or hyaline deposits within a kidney glomerulus, a tuft of capillaries situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney, that filters waste products from the blood and thus initiates urine formation.
has related synonym: kidney glomerulosclerosis measurement
has related synonym: renal glomerulosclerosis measurement
has related synonym: renal glomerulosclerotic lesion measurement

calculated kidney glomerulosclerotic lesion measurement
type: Class
subclass of: kidney glomerulosclerotic lesion measurement
subclass of: calculated kidney non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:43:25Z
def: A measurement of lesions resulting from fibrosis, scarring or hyaline deposits within one or more kidney glomeruli which has been normalized, adjusted or derived by a mathematical process or computation.
has related synonym: calculated kidney glomerulosclerosis measurement
has related synonym: calculated renal glomerulosclerosis measurement
has related synonym: calculated renal glomerulosclerotic lesion measurement

index of glomerular damage
type: Class
subclass of: calculated kidney glomerulosclerotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:45:56Z
def: A measurement of lesions resulting from fibrosis, scarring or hyaline deposits within kidney glomeruli which is derived from a combination of multiple measurements and/or objective or subjective severity scores according to a specified formula or set of criteria.
has related synonym: glomerular damage composite score
has related synonym: glomerulosclerosis composite score
has related synonym: glomerulosclerosis damage index

muscle measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-12T05:28:37Z
def: Any measurement, morphological or physiological of a muscle or a group of muscles. Muscles are organs or tissues composed of bundles of fibers that have the power to contract and hence to produce movement.

kidney glomerulus morphological measurement
type: Class
subclass of: kidney morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:45:27Z
def: Measurement of the physical form or structure of one or more glomeruli in the kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.

kidney glomerulus diameter
type: Class
subclass of: kidney glomerulus morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:48:00Z
def: The length of a straight line passing through the center of a kidney glomerulus and connecting opposite points on its circumference.
has exact synonym: kidney glomerular diameter

calculated renal blood flow rate
type: Class
subclass of: renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:55:42Z
def: A measurement of the volume of blood delivered to or exiting from the kidneys per unit time, which has been normalized, adjusted or derived by a mathematical process or computation.

absolute change in renal blood flow rate
type: Class
subclass of: calculated renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:59:32Z
def: The difference in the volume of blood delivered to or exiting from the kidneys per unit time between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

kidney glomerulosclerotic lesion count
type: Class
subclass of: kidney glomerulosclerotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T12:14:30Z
def: The number of kidney glomeruli with lesions resulting from fibrosis, scarring or hyaline deposits, or the number of such lesions in a specified sample.
has related synonym: damaged glomeruli count
has related synonym: number of sclerotic glomeruli
has related synonym: sclerotic glomeruli count
has related synonym: sclerotic glomerulus count

kidney protein/peptide composition measurement
type: Class
subclass of: kidney molecular composition measurement
subclass of: tissue protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T01:31:20Z
def: Any measurement involving the composition, that is, the absolute amount, relative amount or type of one or more proteins (complex high molecular weight organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) or peptides (low molecular weight compounds composed of at least two amino acids joined by peptide linkages) in kidney.
has exact synonym: kidney tissue protein/peptide composition measurement

renal cortex measurement
type: Class
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:13:42Z
def: Any measurement, morphological or physiological of the outer part of the kidney, composed mainly of glomeruli and convoluted tubules.
has exact synonym: kidney cortex measurement

renal medulla measurement
type: Class
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:20:09Z
def: Any measurement, morphological or physiological, of the renal medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood.
has exact synonym: kidney medulla measurement

renal medulla protein measurement
type: Class
subclass of: renal medulla measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:28:36Z
def: Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in kidney medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood.
has exact synonym: kidney medulla protein measurement

renal cortex protein measurement
type: Class
subclass of: renal cortex measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:31:18Z
def: Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in renal cortex, the outer part of the kidney, composed mainly of glomeruli and convoluted tubules.
has exact synonym: kidney cortex protein measurement

calculated kidney protein composition measurement
type: Class
subclass of: kidney protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:34:08Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the composition, that is, the absolute amount, relative amount or type, of protein (the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) in kidney.
has related synonym: calculated renal protein composition measurement

calculated renal cortex protein composition measurement
type: Class
subclass of: renal cortex protein measurement
subclass of: calculated kidney protein composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:41:53Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation involving the amount, composition or type of protein in the kidney cortex, the outer part of the kidney, composed mainly of glomeruli and convoluted tubules.
has related synonym: calculated kidney cortex protein composition measurement

calculated renal medulla protein composition measurement
type: Class
subclass of: renal medulla protein measurement
subclass of: calculated kidney protein composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:43:38Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation involving the amount, composition or type of protein in the renal medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood.
has exact synonym: calculated kidney medulla protein composition measurement

kidney TRPV4 protein level to beta-actin protein level ratio
type: Class
subclass of: calculated kidney protein composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T04:00:13Z
def: A calculated value in which the amount of TRPV4 protein in a specified sample of kidney is divided by the amount of beta-actin protein in the same or a corresponding sample of kidney and presented as a ratio, fraction or quotient, thus normalizing it to the beta-actin protein level.
has exact synonym: renal TRPV4 protein level to beta-actin protein level ratio

renal cortex TRPV4 protein level to beta-actin protein level ratio
type: Class
subclass of: calculated renal cortex protein composition measurement
subclass of: kidney TRPV4 protein level to beta-actin protein level ratio
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T04:33:48Z
def: A calculated value in which the amount of TRPV4 protein in a specified sample of renal cortex is divided by the amount of beta-actin protein in the same or a corresponding sample of renal cortex and presented as a ratio, fraction or quotient, thus normalizing it to the beta-actin protein level.
has exact synonym: kidney cortex TRPV4 protein level to beta-actin protein level ratio

renal medulla TRPV4 protein level to beta-actin protein level ratio
type: Class
subclass of: calculated renal medulla protein composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T04:35:29Z
def: A calculated value in which the amount of TRPV4 protein in a specified sample of renal medulla is divided by the amount of beta-actin protein in the same or a corresponding sample of renal medulla and presented as a ratio, fraction or quotient, thus normalizing it to the beta-actin protein level.
has related synonym: kidney medulla TRPV4 protein level to beta-actin protein level ratio

calculated cerebral artery inner diameter measurement
type: Class
subclass of: calculated artery inner diameter measurement
subclass of: cerebral artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-23T10:05:50Z
def: The length of a line which crosses a transverse view of a cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall, after that measurement has been normalized or adjusted by a mathematical process or computation. The cerebral arteries are those which supply blood to the brain, more specifically, to the cerebrum.

calculated middle cerebral artery inner diameter measurement
type: Class
subclass of: middle cerebral artery inner diameter
subclass of: calculated cerebral artery inner diameter measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-23T10:06:14Z
def: The length of a line which crosses a transverse view of a middle cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall, after that measurement has been normalized or adjusted by a mathematical process or computation. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain.

percent change in middle cerebral artery inner diameter
type: Class
subclass of: calculated middle cerebral artery inner diameter measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-23T10:09:32Z
def: A calculated measurement of the relative difference in the middle cerebral artery inner diameter between a treated state and a control state or between two points in time, expressed as a percentage.

heart left ventricle end-diastolic area
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-11-12T15:45:39Z
def: A measurement of the extent of a two-dimensional plane through the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter.
has related synonym: EDA
has related synonym: LVAd
has related synonym: LVDa

heart left ventricle end-systolic area
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-11-12T15:47:47Z
def: A measurement of the extent of a two-dimensional plane through the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter.
has related synonym: ESA
has related synonym: LVAs
has related synonym: LVSa

heart weight to tibia length ratio
type: Class
subclass of: calculated heart weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-11-15T15:35:17Z
def: A calculated value in which the weight of the heart, the chambered, muscular organ that maintains the circulation of the blood, is divided by the length of the tibia, the inner and larger bone of the lower leg or hindlimb, and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the length of the leg and, by extension, to the length of the body.

both kidneys wet weight to tibia length ratio
type: Class
subclass of: both kidneys wet weight
subclass of: calculated both kidneys weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-11-15T15:38:38Z
def: A calculated value in which the total weight after removal from the body but without desiccation of both kidneys is divided by the length of the tibia, the inner and larger bone of the lower leg or hindlimb, and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the length of the leg and, by extension, to the length of the body.

change in mean arterial blood pressure to change in intracerebroventricular sodium concentration ratio
type: Class
subclass of: mean arterial blood pressure
subclass of: change in calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-07T13:24:24Z
def: A calculated measurement of the ratio between the change in mean arterial blood pressure and the concentration of sodium infused directly into the ventricle(s) of the brain; calculated as the slope of the curve of mean arterial blood pressure versus intracerebroventricular-infused sodium concentration.

change in heart rate to change in intracerebroventricular sodium concentration ratio
type: Class
subclass of: calculated heart rate measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-07T13:34:46Z
def: A calculated measurement of the ratio between the change in heart rate and the concentration of sodium infused directly into the ventricle(s) of the brain; calculated as the slope of the curve of heart rate versus intracerebroventricular-infused sodium concentration.

ratio of change in renal blood flow to change in renal perfusion pressure
type: Class
subclass of: calculated renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-07T15:55:09Z
def: A value calculated by dividing the proportionate change in renal blood flow (RBF) by the proportionate change in renal perfusion pressure (RPP), i.e. (RBF2 - RBF1)/RBF1 divided by (RPP2 - RPP1)/RPP1.
has related synonym: autoregulatory index
has related synonym: ratio of renal blood flow change to renal perfusion pressure change

kidney fibrotic lesion measurement
type: Class
subclass of: kidney non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-08T14:41:50Z
def: Any measurement of a lesion in the kidney characterized by an abnormal proliferation of fibrous connective tissue. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.

kidney fibrotic lesion size measurement
type: Class
subclass of: kidney fibrotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-08T14:54:45Z
def: Any measurement of the physical dimensions, proportions, magnitude, or extent of a lesion in the kidney characterized by an abnormal proliferation of fibrous connective tissue. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.

kidney fibrotic lesion area measurement
type: Class
subclass of: kidney fibrotic lesion size measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-08T15:03:27Z
def: A measurement of the extent of a two-dimensional surface of or plane through a single kidney fibrotic lesion, or a measurement of the total area occupied by fibrotic lesions in a cross-section of the kidney.

calculated kidney fibrotic lesion area measurement
type: Class
subclass of: kidney fibrotic lesion area measurement
subclass of: calculated kidney non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-08T15:17:52Z
def: A measurement of the extent of a two-dimensional surface of or plane through a single kidney fibrotic lesion, or a measurement of the total area occupied by fibrotic lesions in a cross-section of the kidney, when that value has been normalized, adjusted or derived by a mathematical process or computation.

kidney fibrotic lesion area to total kidney area ratio
type: Class
subclass of: calculated kidney fibrotic lesion area measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-08T15:20:55Z
def: A calculated value in which the extent of the two-dimensional surface occupied by fibrotic lesions is divided by the total extent of the two-dimensional surface of the kidney and presented as a ratio, fraction, quotient or percentage, thus normalizing it to the size of the kidney.

kidney sclerotic glomeruli count to total glomeruli count ratio
type: Class
subclass of: calculated kidney glomerulosclerotic lesion measurement
subclass of: kidney glomerulosclerotic lesion count
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-08T16:28:12Z
def: A calculated value in which the number of glomeruli with lesions resulting from fibrosis, scarring or hyaline deposits is divided by the total number of glomeruli in a specified sample of kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total number of glomeruli.
has alternative id: CMO_0001176
has broad synonym: sclerotic glomeruli to total glomeruli ratio
has exact synonym: kidney glomerulosclerotic lesion count to total glomeruli count ratio

total heart ventricle weight
type: Class
subclass of: heart ventricle weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-09T15:09:49Z
def: The combined weight of both ventricles of the heart, that is, their heaviness or the degree to which they are drawn toward the earth by gravity. The ventricles are the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body.

calculated total heart ventricle weight
type: Class
subclass of: total heart ventricle weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-09T16:00:43Z
def: A measurement of the combined weight of both heart ventricles that has been normalized, adjusted or derived by a mathematical process or computation.
has related synonym: Not4Curation

total heart ventricle weight as a percentage of body weight
type: Class
subclass of: calculated total heart ventricle weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-09T16:03:12Z
def: A calculated value in which the combined weight of both the left and right ventricles, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body, is presented as percentage of the total weight of the body thus normalizing it to body weight.

artery lumen measurement
type: Class
subclass of: artery measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T10:37:51Z
def: Any measurement of the cavity or channel within an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues.

artery lumen area
type: Class
subclass of: artery lumen measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T10:50:23Z
def: A measurement of the two-dimensional extent of the enclosed cavity or channel in a cross-section of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues.

artery wall measurement
type: Class
subclass of: artery measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T11:04:30Z
def: Any measurement of the fibrous and muscular structure of one of the large blood vessels carrying blood in a direction away from the heart to the tissues. The wall of an artery is composed of three layers: the tunica intima, the inner coat; the tunica media, the middle coat; and the tunica adventitia, the outer coat.
has exact synonym: arterial wall measurement

artery tunica media measurement
type: Class
subclass of: artery wall measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T11:17:48Z
def: Any measurement of the tunica media, or middle coat, of the wall of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues.
has exact synonym: arterial tunica media measurement

artery tunica media area
type: Class
subclass of: artery wall thickness
subclass of: artery tunica media measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T11:21:04Z
def: A direct measurement of two dimensional extent of the tunica media, the middle coat of the arterial wall, in a cross-section of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. The total area of the tunica media gives an indication of the thickness of the arterial wall.
has exact synonym: arterial tunica media area
has related synonym: media area (MA) of artery

artery tunica media width
type: Class
subclass of: calculated artery wall thickness measurement
subclass of: artery tunica media measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T11:34:35Z
def: A calculated measurement of the average width of the tunica media, the middle coat of the arterial wall. Can be calculated using the media area and the length of the internal elastic lamina.
has exact synonym: arterial tunica media width
has related synonym: media width (MW) of artery

artery neointimal hyperplastic lesion area
type: Class
subclass of: artery lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T12:10:01Z
def: A measurement of the extent of a two-dimensional surface of or plane through a single hyperplastic lesion of the tunica intima, that is, the inner coat of the arterial wall, or a measurement of the total area occupied by hyperplastic lesions of the tunica intima in a cross-section of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues. A hyperplastic lesion is a localized pathological increase in the number of cells of an organ or tissue resulting from an increased rate of cellular division due to injury or disease; especially one that is circumscribed and well defined.
has related synonym: artery intimal hyperplastic lesion area
has related synonym: neointimal hyperplasia area of artery

calculated artery neointimal hyperplastic lesion area
type: Class
subclass of: calculated artery lesion measurement
subclass of: artery neointimal hyperplastic lesion area
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T12:33:00Z
def: Any measurement of one or more hyperplastic lesions of the arterial tunica intima which has been normalized, adjusted or derived by a mathematical process.
has exact synonym: calculated arterial intima hyperplasia area

artery neointimal hyperplastic lesion area to total wall area ratio
type: Class
subclass of: calculated artery neointimal hyperplastic lesion area
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T12:33:16Z
def: A calculated measurement in which the area of the arterial tunica intima occupied by one or more hyperplastic lesions is divided by the total cross-sectional area of the artery wall and presented as a ratio, fraction, quotient or percentage.
has exact synonym: ratio of neointimal hyperplasia area to total wall area of artery

lesioned artery residual lumen area
type: Class
subclass of: calculated artery lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-15T12:50:46Z
def: The area of the arterial lumen remaining when the luminal space is restricted by a pathological process, e.g. hyperplasia.
has exact synonym: residual lumen area of diseased artery

both kidneys dry weight
type: Class
subclass of: kidney dry weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-16T13:36:09Z
def: The weight after desiccation of both kidneys, the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

single kidney dry weight
type: Class
subclass of: kidney dry weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-16T13:36:57Z
def: The weight after desiccation of a single kidney, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: individual kidney dry weight

aorta measurement
type: Class
subclass of: artery measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-21T16:32:31Z
def: Any measurement of the great artery arising from the left ventricle from which the systemic arterial system proceeds.

aorta morphological measurement
type: Class
subclass of: aorta measurement
subclass of: blood vessel morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-21T16:37:23Z
def: Any quantification of the physical form or structure of the great artery arising from the left ventricle from which the systemic arterial system proceeds.

blood flow velocity
type: Class
subclass of: circulation measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T12:50:21Z
def: The speed at which the blood flows through the circulatory system or through a specific segment of a vein or artery, expressed as distance per unit of time.

arterial blood flow velocity
type: Class
subclass of: blood flow velocity
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T12:56:43Z
def: The speed at which the blood flows through an artery, expressed as distance per unit of time.

aortic blood flow velocity
type: Class
subclass of: arterial blood flow velocity
subclass of: aortic blood flow measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:10:05Z
def: The speed at which the blood flows through the aorta, the great artery arising from the left ventricle from which the systemic arterial system proceeds, expressed as distance per unit of time.

aortic blood flow measurement
type: Class
subclass of: aorta measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:15:01Z
def: Any measurement of the movement of blood through the aorta, the great artery arising from the left ventricle from which the systemic arterial system proceeds.

aortic blood flow rate
type: Class
subclass of: arterial blood flow rate
subclass of: aortic blood flow measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:18:41Z
def: The volume of blood flowing through the aorta, the great artery arising from the left ventricle from which the systemic arterial system proceeds, per unit of time.

peak aortic velocity
type: Class
subclass of: aortic blood flow velocity
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:21:50Z
def: The maximum speed at which the blood flows through the aorta during the cardiac cycle, expressed as distance per unit of time.
has exact synonym: aortic peak velocity (APV)
has exact synonym: maximum aortic velocity
has exact synonym: peak aortic blood flow velocity
has exact synonym: peak of aortic outflow velocity (PAV)

heart isovolumetric relaxation time
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:29:29Z
def: The length of time in the cardiac cycle between the closing of the aortic and pulmonic/pulmonary semilunar valves and opening of the atrioventricular (AV) valves marking the beginning of ventricular filling. Used as an indicator of diastolic dysfunction.
has related synonym: IVRT

heart left atrium morphological measurement
type: Class
subclass of: heart atrium morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:35:08Z
def: Measurement of the physical form or structure of the left upper chamber of the heart that receives blood from the veins and forces it into the left ventricle.

heart right atrium morphological measurement
type: Class
subclass of: heart atrium morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:42:05Z
def: Measurement of the physical form or structure of the right upper chamber of the heart that receives blood from the veins and forces it into the right ventricle.

heart left atrium end-systolic diameter
type: Class
subclass of: heart left atrium morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T13:51:15Z
def: The distance between two specified opposite points on the periphery of the left atrium of the heart at the end of systole, that is, when the left ventricle is maximally contracted, and usually corresponds to the left atrium's largest diameter.

heart left atrium end-diastolic diameter
type: Class
subclass of: heart left atrium morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T15:50:33Z
def: The distance between two specified opposite points on the periphery of the left atrium of the heart at the end of diastole, that is, when the left ventricle is maximally dilated, and usually corresponds to the left atrium's smallest diameter.

calculated heart left atrium morphological measurement
type: Class
subclass of: heart left atrium morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T15:51:30Z
def: A measurement of the physical form or structure of the left atrium, the left upper chamber of the heart that receives blood from the veins and forces it into the left ventricle, which has been normalized, adjusted or derived by a mathematical process or computation.

heart left atrium fractional shortening
type: Class
subclass of: calculated heart left atrium morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-25T16:00:18Z
def: A calculated measurement corresponding to the ratio or percent reduction in left atrial diameter between end-systole and end-diastole. It is calculated as the left atrium end-systolic diameter (LADs) minus the left atrium end-diastolic diameter (LADd) divided by the left atrium end-systolic diameter (LADs).

blood mononuclear cell count
type: Class
subclass of: blood differential white blood cell count
subclass of: mononuclear cell count
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-28T16:41:10Z
def: Measurement of the number of white blood cells, including lymphocytes and monocytes, with a single round or oval nucleus in a specified volume of blood.
has related synonym: mononuclear leukocyte count

calculated blood flow measurement
type: Class
subclass of: circulation measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-30T14:16:47Z
def: A measurement of the movement of blood through one or more vessels or organs in the body which has been normalized, adjusted or derived by a mathematical process or computation.

myocardium measurement
type: Class
subclass of: heart measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-03-15T17:22:25Z
def: Any measurement of the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart wall.

myocardial flow rate
type: Class
subclass of: blood flow rate
subclass of: myocardium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-03-15T17:29:25Z
def: The volume of fluid flowing into, out of or through the blood vessels and microvasculature of the myocardium, the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart wall, per unit time.

myocardial clearance rate
type: Class
subclass of: myocardium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-03-15T17:38:35Z
def: Measurement of the amount of radioactive or other tracer is lost from the myocardium, the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart wall, per unit time.

blood vessel smooth muscle measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T10:33:25Z
def: A value resulting from the quantification of a morphological or physiological parameter of vascular smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of blood vessels, the network of muscular tubes that carry blood through the body.
has exact synonym: vascular smooth muscle measurement
has related synonym: Not4Curation

aorta wall morphological measurement
type: Class
subclass of: aorta morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T10:41:10Z
def: Any quantification of the physical form or structure of the layered tissue which encloses and constitutes the structural component of the great artery arising from the left ventricle from which the systemic arterial system proceeds.
has exact synonym: aortic wall morphological measurement

aorta smooth muscle cell count
type: Class
subclass of: aorta wall morphological measurement
subclass of: blood vessel smooth muscle cell count
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T10:42:34Z
def: Measurement of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of the aorta smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of the great artery arising from the left ventricle from which the systemic arterial system proceeds.
has exact synonym: aortic smooth muscle cell count

blood vessel smooth muscle cell count
type: Class
subclass of: blood vessel smooth muscle measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T11:29:28Z
def: Measurement of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of vascular smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of blood vessels, the network of muscular tubes that carry blood through the body.
has exact synonym: vascular smooth muscle cell count

calculated blood vessel smooth muscle cell count
type: Class
subclass of: blood vessel smooth muscle cell count
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T12:57:40Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of vascular smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of blood vessels, the network of muscular tubes that carry blood through the body.
has exact synonym: calculated vascular smooth muscle cell count

calculated aorta smooth muscle cell count
type: Class
subclass of: calculated blood vessel smooth muscle cell count
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T12:59:11Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of the aorta smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of the great artery arising from the left ventricle from which the systemic arterial system proceeds.
has exact synonym: calculated aortic smooth muscle cell count

aorta smooth muscle cell count per unit vessel length
type: Class
subclass of: calculated aorta smooth muscle cell count
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T13:25:39Z
def: A calculated value in which the total number of cells, membrane-enclosed protoplasmic masses constituting the smallest structural unit of an organism that is capable of independent functioning, in a specified sample of the aorta smooth muscle, the contractile soft tissue having fine myofibrils but lacking transverse striations composing the majority of the wall of the great artery arising from the left ventricle from which the systemic arterial system proceeds, is divided by the length of the smooth muscle section in which that number is determined.
has exact synonym: aortic smooth muscle cell count per unit vessel length

heart left ventricle deoxyribonucleic acid content
type: Class
subclass of: heart left ventricle molecular composition measurement
subclass of: heart nucleic acid measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T14:44:11Z
def: The amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart left ventricle, the lower chamber of the left side of the heart (from the perspective of the organism rather than the observer), which pumps oxygenated blood out through the aorta to all the tissues of the body.
has related synonym: heart LV DNA content
has related synonym: heart left ventricle DNA content

calculated heart left ventricle deoxyribonucleic acid content
type: Class
subclass of: calculated heart left ventricle morphological measurement
subclass of: heart left ventricle deoxyribonucleic acid content
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T14:46:40Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart left ventricle, the lower chamber of the left side of the heart (from the perspective of the organism rather than the observer), which pumps oxygenated blood out through the aorta to all the tissues of the body.
has related synonym: calculated heart LV DNA content
has related synonym: calculated heart left ventricle DNA content

heart left ventricle deoxyribonucleic acid content to body weight ratio
type: Class
subclass of: calculated heart left ventricle deoxyribonucleic acid content
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T14:49:33Z
def: A calculated measurement in which amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart left ventricle, the lower chamber of the left side of the heart (from the perspective of the organism rather than the observer), which pumps oxygenated blood out through the aorta to all the tissues of the body, is divided by the total weight or heaviness of the body and presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism.
has related synonym: heart LV DNA content to body weight ratio
has related synonym: heart left ventricle DNA content to BW ratio
has related synonym: heart left ventricle DNA content to body weight ratio

heart right ventricle deoxyribonucleic acid content
type: Class
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T14:52:32Z
def: The amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung.
has related synonym: heart RV DNA content
has related synonym: heart right ventricle DNA content

calculated heart right ventricle deoxyribonucleic acid content
type: Class
subclass of: calculated heart right ventricle morphological measurement
subclass of: heart right ventricle deoxyribonucleic acid content
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T14:54:27Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung.
has related synonym: calculated heart RV DNA content
has related synonym: calculated heart right ventricle DNA content

heart right ventricle deoxyribonucleic acid content to body weight ratio
type: Class
subclass of: calculated heart right ventricle deoxyribonucleic acid content
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-18T14:56:34Z
def: A calculated measurement in which amount of deoxyribonucleic acid (DNA), the molecule composed of the sugar deoxyribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or thymine, extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is divided by the total weight or heaviness of the body and presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism.
has related synonym: heart RV DNA content to body weight ratio
has related synonym: heart right ventricle DNA content to BW ratio
has related synonym: heart right ventricle DNA content to body weight ratio

receptor-independent blood vessel maximum contractile force
type: Class
subclass of: blood vessel maximum contractile force
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-20T14:09:54Z
def: Measurement of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from a contraction of the muscular wall of the vessel which does not involve the action of a receptor, a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect.
has related synonym: blood vessel receptor-independent maximum contractility

receptor-dependent blood vessel maximum contractile force
type: Class
subclass of: blood vessel maximum contractile force
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-20T14:10:59Z
def: Measurement of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from a contraction of the muscular wall of the vessel which is instigated by the activation of a receptor, a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect.
has related synonym: blood vessel receptor-dependent maximum contractility

calculated blood vessel maximum contractile force measurement
type: Class
subclass of: blood vessel maximum contractile force
subclass of: calculated blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-20T14:12:17Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel.

receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio
type: Class
subclass of: calculated blood vessel maximum contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-20T14:14:00Z
def: A calculated measurement in which the receptor-dependent maximum contractile force of a blood vessel is divided by the receptor-independent maximum contractile force of a blood vessel and presented as a ratio, fraction, quotient or percentage. The maximum contractile force of a blood vessel is the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from a contraction of the muscular wall of the vessel. Receptor-dependent refers to such a contraction which is instigated by the activation of a receptor, a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect. Receptor-independent denotes such a contraction that does not involve the action of a receptor.
has related synonym: blood vessel receptor-dependent contractility to receptor-independent contractility ratio
has related synonym: receptor-dependent blood vessel maximum contractile force exoressed as a percentage of receptor-independent blood vessel maximum contractile force

concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (EC50)
type: Class
subclass of: angiotensin II response/sensitivity measurement
subclass of: concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50)
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-20T14:22:08Z
def: A calculated value for the concentration of angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of AngII is halfway between the baseline value and the highest achievable value of such AngII-induced contractile energy.
has related synonym: Ang2 half maximal effective concentration
has related synonym: AngII half maximal effective concentration
has related synonym: angiotensin 2 half maximal effective concentration
has related synonym: angiotensin II half maximal effective concentration (EC50)
xref: CHEBI_48432

logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)
type: Class
subclass of: angiotensin II response/sensitivity measurement
subclass of: logarithm of the concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (Log EC50)
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-20T14:24:41Z
def: A calculated value for logarithm of the concentration of angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of AngII is halfway between the baseline value and the highest achievable value of such AngII-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
has related synonym: Ang2 Log half maximal effective concentration
has related synonym: AngII Log half maximal effective concentration
has related synonym: angiotensin 2 Log half maximal effective concentration
has related synonym: angiotensin II Log half maximal effective concentration (EC50)
xref: CHEBI_48432

angiotensin II response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-06-20T15:45:33Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion.
xref: CHEBI_48432

absolute change in left ventricular diastolic blood pressure
type: Class
subclass of: left ventricular diastolic blood pressure
subclass of: absolute change in diastolic blood pressure
subclass of: calculated left ventricular blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-07-31T13:40:52Z
def: The difference in left ventricular diastolic blood pressure between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
has related synonym: absolute change in LVDBP
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

calculated left ventricular blood pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-07-31T15:17:53Z
def: Any measurement of the blood pressure in the left ventricle of the heart which has been normalized or adjusted by a mathematical process or computation. Left ventricular blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.
has related synonym: calculated left ventricular pressure

maximum rate of positive change in left ventricular blood pressure
type: Class
subclass of: calculated left ventricular blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-07-31T15:24:11Z
def: A calculated measurement that is used as an index to characterize the contractile ability of the heart. It is believed that maximum dP/dt is a reasonable index of the initial velocity of myocardial contraction.
has related synonym: LV +dP/dt Max
has related synonym: peak +LVdP/dt
has related synonym: rate of maximum positive change in left ventricular blood pressure

maximum rate of negative change in left ventricular blood pressure
type: Class
subclass of: calculated left ventricular blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-07-31T15:27:12Z
def: A calculated hemodynamic measurement related to the ability of the heart left ventricle to relax. The point at which the negative pressure fall velocity reaches its peak is taken to be the onset of isovolumic relaxation of the left ventricle.
has related synonym: LV -dP/dt Max
has related synonym: peak -LVdP/dt
has related synonym: rate of maximum negative change in left ventricular blood pressure

time constant of left ventricular pressure decay
type: Class
subclass of: calculated left ventricular blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-07-31T15:29:00Z
def: A calculated hemodynamic value related to the ability of the heart left ventricle to relax. Tau is calculated as an exponential function of the change in intraventricular pressure during the diastolic isovolumic left ventricular pressure decrease.
has related synonym: time constant of left ventricular relaxation

heart left ventricle end-systolic posterior wall thickness
type: Class
subclass of: heart left ventricle posterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2013-10-16T12:18:32Z
def: The thickness or depth (i.e. the measurement of the two-dimensional extent of the distance between the inner and outer surfaces) of the dorsal/posterior wall of the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.
has exact synonym: end-systolic heart left ventricle posterior wall thickness
has related synonym: end-systolic heart left ventricle PWT
comment: Note that "left" in this context refers to the perspective of the organism, not that of the observer.

kidney molecular composition measurement
type: Class
subclass of: kidney morphological measurement
subclass of: tissue molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-04T17:14:28Z
def: Any quantification of the amounts or proportions of proteins, lipids, minerals, nutrients, gases, or other substances ina specified sample of kidney tissue, that is, tissue from one or both of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

kidney lipid composition measurement
type: Class
subclass of: kidney molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-04T17:16:16Z
def: Quanitification of one or more lipids in a specified sample of kidney tissue, that is, tissue from one or both of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. A lipid is any of a structurally diverse group of organic compounds that are insoluble in water but soluble innonpolar solvents that, among other biological functions, serve as a source of fuel and are an important constituent of cell structure.

kidney 20-HETE level
type: Class
subclass of: kidney lipid composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-04T17:22:56Z
def: The amount of 20-hydroxyeicosatetraenoic acid, a vasoconstrictor that consists of arachidonic acid (a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14) bearing a hydroxy substituent at position 20, in a specified sample of kidney tissue, that is, tissue from one or both of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: kidney 20-hydroxyeicosatetraenoic acid level
xref: CHEBI_34306

immune cell count
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-07T16:12:26Z
def: The number of immune cells in a specified sample. An immune cell is any cell involved in the immune system, a complex set of interconnected and interdependent cellular and molecular components having the primary functions of distinguishing self from not self and of defense against foreign organisms or substances. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.

absolute change in pulse pressure
type: Class
subclass of: pulse pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-08T16:00:08Z
def: The difference in the pulse pressure of an individual between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. Pulse pressure is the difference between systolic and diastolic blood pressures, i.e. the difference between the maximal arterial pressure and minimal arterial pressure during the cardiac cycle.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

compensatory renal growth score
type: Class
subclass of: calculated kidney weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-18T15:00:01Z
def: A calculated measurement of the degree to which a change in the size of the remaining kidney after surgical removal of the other kidney can be attributed to compensatory growth, calculated as the ratio of the normalized weight of a single kidney at the time of surgical removal divided by the similarly normalized weight of the single remaining kidney at a specified period of time after removal. The normalized kidney weight is the weight of the kidney corrected for body weight using an empirically determined allometric scaling factor (i.e., an exponential factor which adjusts for the normal increase in kidney weight due to normal growth and development of the individual). Compensatory growth is the phenomenon in which the impaired function of one organ in a paired organ system or of part of an organ in a single organ system is followed by enlargement of the surviving organ or tissue so that functional capacity is maintained. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has related synonym: CRG score

ratio of change in renal blood flow rate to kidney weight
type: Class
subclass of: calculated renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-18T16:20:39Z
def: A calculated measurement in which the difference in the volume of blood delivered to and/or exiting from the kidneys per unit time between two points in time or two conditions is divided by the weight (heaviness or degree to which a body is drawn toward the earth by gravity) of one or both kidneys, and presented as a ratio, fraction, quotient or percentage. The kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

renal vascular resistance
type: Class
subclass of: blood vessel resistance measurement
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-18T17:22:16Z
def: A measurement of the degree to which the blood vessels of the kidneys impede the flow of blood through them. Renal vascular resistance is calculated as the renal blood flow rate divided by the mean arterial pressure.
has exact synonym: kidney vascular resistance

calculated renal vascular resistance
type: Class
subclass of: renal vascular resistance
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-18T17:23:40Z
def: A measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the degree to which the blood vessels of the kidneys impede the flow of blood through them. Blood vessels are the network of muscular tubes that carry blood throughout the body. Blood is the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: calculated kidney vascular resistance

absolute change in renal vascular resistance
type: Class
subclass of: calculated renal vascular resistance
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-18T17:26:57Z
def: The difference in renal vascular resistance between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity. Renal vascular resistance is the degree to which the blood vessels of the kidneys impede the flow of blood through them. Blood vessels are the network of muscular tubes that carry blood throughout the body. Blood is the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: absolute change in kidney vascular resistance
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

slope of contraction-induced renal vascular resistance curve
type: Class
subclass of: calculated renal vascular resistance
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-18T17:27:01Z
def: A calculated measurement of the slope, the ratio of vertical change to horizontal change, of the line of a graph designating the change in renal vascular resistance in response to a drug or other condition which causes constriction or reduction of the interior diameter of blood vessels. Renal vascular resistance is the degree to which the blood vessels of the kidneys impede the flow of blood through them. Blood vessels are the network of muscular tubes that carry blood throughout the body. Blood is the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. Kidney is the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: slope of constriction-induced renal vascular resistance curve
has exact synonym: slope of contraction-induced kidney vascular resistance curve

artery internal elastic lamina non-tumorous lesion count
type: Class
subclass of: artery lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-19T13:00:18Z
def: The enumeration, i.e. measurement of the total number, of defects or lesions of the internal elastic lamina which are not hyperplastic or neoplastic in origin in a specified sample of artery. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. The internal elastic lamina (IEL) is a fenestrated (perforated) layer of elastic tissue, i.e., one having the property of returning to the original shape after being distorted, that is the outermost part of the intima (innermost layer) of an artery. The IEL is the elastic layer that is situated between the tunica intima (inner layers) and tunica media (middle layers) of artery walls. An artery is any one of the branching system of muscular, elastic blood vessels that carry blood away from the heart.
has related synonym: artery internal elastic lamina defect count

renal plasma flow
type: Class
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-19T14:28:34Z
def: The amount of plasma that perfuses the kidneys per unit time. Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: renal plasma flow rate
has related synonym: RPF

ratio of the effective renal plasma flow to the weight of both kidneys
type: Class
subclass of: effective renal plasma flow
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-19T14:51:51Z
def: A calculated measurement in which the effective renal plasma flow rate (eRPF) is divided by weight (i.e. the heaviness or the degree to which an object is drawn toward the earth by gravity) of both kidneys and presented as a ratio, fraction, quotient or percentage. The eRPF is the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of a non-metabolizable solute such as para-aminohippurate (PAH). Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: effective renal plasma flow rate to both kidney weight ratio
has related synonym: eRPF to both kidney weight ratio

effective renal plasma flow
type: Class
subclass of: calculated renal plasma flow
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-19T14:52:06Z
def: A calculated measurement of the amount of plasma that perfuses the renal tubules per unit time, derived by measurement of the clearance rate of a non-metabolizable solute such as para-aminohippurate (PAH). The effective RPF is approximately 10% less than the actual RPF. Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: effective renal plasma flow rate
has related synonym: eRPF

calculated renal plasma flow
type: Class
subclass of: renal plasma flow
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-19T14:52:10Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of plasma that perfuses the kidneys per unit time. Plasma is the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. The kidneys are the paired organs that function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: calculated renal plasma flow rate
has related synonym: calculated RPF

calculated single kidney weight
type: Class
subclass of: calculated kidney weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-26T15:36:46Z
def: Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the weight of only one of the kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

calculated both kidneys weight
type: Class
subclass of: calculated kidney weight
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-26T15:39:42Z
def: Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the weight of both (the complete set of two) of the kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

right kidney wet weight to body weight ratio
type: Class
subclass of: right kidney wet weight
subclass of: single kidney wet weight to body weight ratio
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-26T15:48:04Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of only the single right kidney is divided by the total weight of the body and presented as a ratio, fraction, quotient or percent, thus normalizing it to body weight and by extension to the size of the organism. The right kidney is the organ which lies on the right side of the body from the perspective of the subject.
has exact synonym: individual right kidney wet weight to body weight ratio

left kidney wet weight to body weight ratio
type: Class
subclass of: left kidney wet weight
subclass of: single kidney wet weight to body weight ratio
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-26T15:48:07Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of only the left kidney is divided by the total weight of the body and presented as a ratio, fraction, quotient or percent, thus normalizing it to body weight and, by extension, to the size of the organism. The left kidney is the organ which lies on the left side of the body from the perspective of the subject.
has exact synonym: individual left kidney wet weight to body weight ratio

renal blood flow rate to kidney weight ratio
type: Class
subclass of: calculated renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2013-11-26T16:04:13Z
def: A calculated measurement in which the value for the volume of blood delivered to and/or exiting from the kidneys per unit time is divided by the weight (heaviness or degree to which an object is drawn toward the earth by gravity) of one or both kidneys, and presented as a ratio, fraction, quotient or percentage.

change in mean arterial blood pressure to change in the logarithm of the vasoconstrictor dose ratio
type: Class
subclass of: mean arterial blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-02T10:53:31Z
def: A calculated measurement in which difference in the mean arterial blood pressure between two or more dosages of a drug or chemical which reduces the interior diameter of blood vessels is divided by difference in the logarithm of the applied dosages and presented as a ratio, fraction, quotient or percentage. The value is calculated as the slope of the curve of the mean arterial blood pressure versus log of the vasoconstrictor dose [VC] graph, given by the equation (log[VC]2 - log[VC]1)/(MAP at [VC]2 - MAP at [VC]1). A logarithm is the power to which a base, such as 10, must be raised to produce a given number.
has related synonym: change in MAP to change in log[vasoconstrictor] ratio

kidney glomerulosclerotic lesion diameter
type: Class
subclass of: kidney glomerulosclerotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-02T11:03:44Z
def: Measurement of the length of a straight line passing through the center and connecting opposite points on the circumference of a circle delineating the outer limits of a glomerulosclerotic lesion.

kidney glomerulosclerotic lesion diameter to mean arterial blood pressure ratio
type: Class
subclass of: calculated kidney glomerulosclerotic lesion measurement
subclass of: kidney glomerulosclerotic lesion diameter
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-02T11:54:57Z
def: A calculated measurement in which the diameter of kidney glomerular injury is divided by the value of the mean arterial blood pressure and presented as a ratio, fraction, quotient or percentage, for example to give an index of kidney damage relative to the level of hypertension.

blood vessel morphological measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-03T17:32:45Z
def: Measurement of the physical form or structure of one or more blood vessels, the network of muscular tubes that carry blood through the body.

aorta wall molecular composition measurement
type: Class
subclass of: aorta wall morphological measurement
subclass of: tissue molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-03T18:01:02Z
def: Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the wall of the aorta, the layered tissue which encloses and constitutes the structural component of the great artery arising from the left ventricle from which the systemic arterial system proceeds. A molecule is an aggregation of atoms, specifically a chemical combination of two or more atoms forming a specific chemical substance.
has exact synonym: aortic wall molecular composition measurement

aorta wall extracellular elastin level
type: Class
subclass of: aorta wall protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-03T18:08:51Z
def: The amount of elastin in a specified sample of aorta wall tissue. Elastin is an elastic, fibrous mucoprotein, similar to collagen, and the major connective tissue protein of elastic fibers, such as those in arterial walls.
has exact synonym: aortic wall elastin level

aorta wall extracellular collagen level
type: Class
subclass of: aorta wall protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-03T18:13:06Z
def: The amount of collagen in a specified sample of aorta wall tissue. Collagen refers to any of a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility.
has exact synonym: aortic wall collagen level

calculated aorta wall molecular composition measurement
type: Class
subclass of: aorta wall molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-03T18:14:39Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the molecules, atoms and/or ions which constitute the chemical make-up of the wall of the aorta.
has exact synonym: calculated aortic wall molecular composition measurement

aorta wall extracellular elastin dry weight to aorta wall dry weight ratio
type: Class
subclass of: aorta wall extracellular elastin level
subclass of: calculated aorta wall molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-03T18:21:20Z
def: A calculated measurement in which the weight after dessication of the extracellular elastin in a specified sample of aorta wall is divided by the total weight after dessication of that sample of aorta wall, and the result presented as a ratio, fraction, quotient or percentage.
has exact synonym: aortic wall elastin dry weight to total aortic wall dry weight ratio

aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio
type: Class
subclass of: aorta wall extracellular elastin level
subclass of: aorta wall extracellular collagen level
subclass of: calculated aorta wall molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-03T18:29:26Z
def: A calculated measurement in which the weight after dessication of the extracellular elastin in a specified sample of aorta wall is divided by the weight of extracellular collagen in that sample of aorta wall, and the result presented as a ratio, fraction, quotient or percentage.
has exact synonym: aortic wall elastin dry weight to aortic wall collagen weight ratio

aorta wall intracellular protein level
type: Class
subclass of: aorta wall protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2013-12-04T10:31:25Z
def: The total amount of protein extracted from within the cells of the aortic wall in a specified sample of aorta. Protein is any of a group of complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages.
has related synonym: aorta cellular protein level
has related synonym: aorta wall total intracellular protein level

percent change in mean arterial blood pressure
type: Class
subclass of: mean arterial blood pressure
subclass of: change in calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-07T16:35:21Z
def: The difference in mean arterial blood pressure between two points in time or two conditions expressed as a percentage (the proportion or rate per hundred parts).
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

change in heart rate to change in mean arterial blood pressure ratio
type: Class
subclass of: mean arterial blood pressure
subclass of: change in calculated blood pressure
subclass of: calculated heart rate measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-07T16:51:06Z
def: Average slope of the line defined by the change in heart rate (the number of contractions of the cardiac ventricles per unit of time) relative to the change in mean arterial blood pressure (the average force the blood exerts on an artery wall) over time and/or in response to a change in conditions.

maximum change in heart rate to change in mean arterial blood pressure ratio
type: Class
subclass of: change in heart rate to change in mean arterial blood pressure ratio
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-07T16:53:44Z
def: Maximum, largest or steepest slope of the line defined by the change in heart rate (the number of contractions of the cardiac ventricles per unit of time) relative to the change in mean arterial blood pressure (the average blood pressure within an artery over a specified period of time) over time and/or in response to a change in conditions.

blood sterol level
type: Class
subclass of: blood chemistry measurement
subclass of: blood lipid measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-23T17:03:36Z
def: The amount of sterol, any of a group of steroids with a long (8 to 10 carbons) aliphatic side-chain at position 17 and at least one alcoholic group, in a specified sample of blood.

serum sterol level
type: Class
subclass of: blood lipid measurement
subclass of: blood sterol level
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-23T17:04:50Z
def: The amount of sterol, any of a group of steroids with a long (8 to 10 carbons) aliphatic side-chain at position 17 and at least one alcoholic group, in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed.

tissue molecular composition measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-24T15:13:32Z
def: Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of a specified tissue or set of tissues.

mononuclear cell count
type: Class
subclass of: cell measurement
subclass of: immune cell count
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-27T15:49:38Z
def: Determination of the number of mononuclear cells, i.e. leukocytes such as lymphocytes and monocytes with a single round or oval nucleus (including but not limited to such cells found in blood, lymph or spleen) found in a specified sample.
has related synonym: mononuclear cell number

kidney crescentic glomeruli count to kidney normal glomeruli count ratio
type: Class
subclass of: calculated kidney glomerulosclerotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-28T16:41:28Z
def: A calculated measurement in which .the number of kidney glomeruli displaying an abnormal (i.e., pathogenic) crescentic morphology is divided by the number of kidney glomeruli displaying normal morphology, and the result presented as a ratio, fraction, quotient or percentage.

calculated heart rate measurement
type: Class
subclass of: heart rate
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-31T16:39:20Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of heart rate, the number of contractions of the cardiac ventricles per unit of time.

absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio
type: Class
subclass of: calculated heart rate measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-01-31T16:41:23Z
def: The difference between two points in time or two conditions in heart rate expressed as the ratio of the low frequency R-R interval component of the power spectrum analysis to the high frequency R-R interval component of the power spectrum analysis, expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
has broad synonym: absolute change in heart rate variability
has related synonym: absolute change in ECG LF/HF ratio
has related synonym: absolute change in EKG LF/HF ratio
has related synonym: absolute change in electrocardiographic low frequency R-R interval to high frequency R-R interval ratio
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

heart left ventricle molecular composition measurement
type: Class
subclass of: heart left ventricle morphological measurement
subclass of: heart molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-02-03T17:42:14Z
def: Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the tissue(s) of the heart left ventricle. A molecule is an aggregation of atoms, specifically a chemical combination of two or more atoms forming a specific chemical substance.

heart left ventricle natriuretic peptide A level
type: Class
subclass of: heart left ventricle molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-02-03T17:43:11Z
def: The amount in a specified sample of tissue from the heart left ventricle, of natriuretic peptide A (NPPA), a powerful vasodilator and peptide hormone secreted mainly by heart muscle cells and involved in control of extracellular fluid volume and electrolyte homeostasis.
has exact synonym: heart left ventricle atrial natriuretic factor level
has exact synonym: heart left ventricle natriuretic peptide A protein level
has related synonym: heart left ventricle NPPA level

kidney renin level
type: Class
subclass of: kidney protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-02-03T17:55:31Z
def: The amount of renin in a specified sample of kidney tissue. Renin, an aspartyl protease, catalyzes the cleavage of angiotensinogen to form angiotensin I, the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure.
has exact synonym: kidney renin protein level
has related synonym: kidney REN level

kidney protein activity measurement
type: Class
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T15:24:43Z
def: Any quantification of the ability of a protein of the kidney to accomplish an effect, e.g. take part in a chemical reaction or carry out a specified molecular function.

kidney enzyme activity measurement
type: Class
subclass of: kidney protein activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T15:31:04Z
def: Any quantification of the ability of a kidney enzyme, i.e. a protein located in the kidney that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions, to carry out its specified molecular function.

kidney catalase activity to total protein level ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:51:03Z
def: A calculated measurement in which the level of catalase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen.

kidney glucose-6-phosphate dehydrogenase activity to total protein level ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:52:00Z
def: A calculated measurement in which the level of glucose-6-phosphate dehydrogenase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Glucose-6-phosphate dehydrogenase catalizes the conversion of D-glucose 6-phosphate + NADP+ to 6-phospho-D-glucono-1,5-lactone + NADPH.
has related synonym: kidney G6PD activity to total protein level ratio

kidney glutathione reductase activity to total protein level ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:53:05Z
def: A calculated measurement in which the level of glutathione reductase (GSR) enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. GSR reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH.
has related synonym: kidney GSR activity to total protein level ratio

kidney glutathione peroxidase activity to total protein level ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:54:38Z
def: A calculated measurement in which the level of glutathione peroxidase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Glutathione peroxidases constitute a family of proteins that reduce lipid hydroperoxides to their corresponding alcohols and reduce free hydrogen peroxide to water.

kidney glutathione-S-transferase activity to total protein level ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:55:21Z
def: A calculated measurement in which the level of glutathione-S-transferase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Glutathione-S-transferase refers to any of a family of proteins with the ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification.

kidney superoxide dismutase activity to total protein level ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:55:56Z
def: A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. superoxide dismutases constitute a family of proteins that convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide.

kidney paraoxonase1 activity to total protein level ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:56:39Z
def: A calculated measurement in which the level of paraoxonase 1 enzyme activity in a specified sample of kidney is divided by the weight of total protein in that sample. Paraoxonase 1 is an arylesterase that mainly hydrolyzes paroxon, an organophosphorus anticholinesterase compound, to produce p-nitrophenol.
has exact synonym: kidney paraoxonase-1 activity to total protein level ratio

kidney glutathione peroxidase activity to glutathione reductase activity ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:57:32Z
def: A calculated measurement in which the level of glutathione peroxidase enzyme activity in a specified sample of kidney is divided by the level of glutathione reductase enzyme activity in that same sample.

kidney superoxide dismutase to catalase activity ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:58:30Z
def: A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the level of catalase enzyme activity in that same sample.

kidney superoxide dismutase to glutathione peroxidase ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:59:04Z
def: A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the level of glutathione peroxidase enzyme activity in that same sample.

kidney superoxide dismutase to paraoxonase1 activity ratio
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T17:59:34Z
def: A calculated measurement in which the level of superoxide dismutase enzyme activity in a specified sample of kidney is divided by the level of paraoxonase 1 enzyme activity in that same sample.
has exact synonym: kidney superoxide dismutase to paraoxonase-1 activity ratio

kidney glutathione level
type: Class
subclass of: kidney protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T18:02:47Z
def: The amount of glutathione in a specified sample of kidney tissue. Glutathione (GSH/GSSG) is an antioxidant tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain.
has related synonym: kidney GSH level
xref: CHEBI_16856

kidney malondialdehyde level
type: Class
subclass of: kidney molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T18:03:40Z
def: The amount of malondialdehyde in a specified sample of kidney tissue. Malondialdehyde is an organic compound with the formula CH2(CHO)2. It is a reactive species which occurs naturally, is generally found in the enol form (HOCH=CH-CHO), and is a marker for oxidative stress.
xref: CHEBI_566274

kidney protein carbonyl level to total protein level ratio
type: Class
subclass of: calculated kidney protein composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T18:04:53Z
def: A calculated measurement in which the level of protein carbonyl (PCO) derivatives in a specified sample of kidney is divided by the total amount of protein in the sample. Protein carbonyl (PCO) derivatives are produced by the oxidation of amino acids and can be used as a marker of oxidative stress.

kidney platinum level
type: Class
subclass of: kidney molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-10T18:06:09Z
def: The amount of platinum, the chemical element with atomic number 78, in a specified sample of kidney tissue.
xref: CHEBI_33364

serum creatine kinase activity level
type: Class
subclass of: blood enzyme activity level
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-11T14:14:26Z
def: The amount of enzymatic activity of creatine kinase (CK) enzyme in a specified sample of serum. CK catalyses the reversible transfer of phosphate between ATP and various phosphogens such as creatine phosphate. Serum CK level is used as an enzymatic marker for myocardial infarction, rhabdomyolysis and acute renal failure.
has exact synonym: serum creatine phosphokinase activity level
has related synonym: serum CK activity level
has related synonym: serum CPK activity level

kidney lipid peroxide level
type: Class
subclass of: kidney lipid composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-11T16:52:38Z
def: The amount of lipid peroxidation end products in a specified sample of kidney tissue. Lipid peroxidation is the oxidative degradation of lipids.
has related synonym: kidney LPO level
has related synonym: kidney lipid peroxidation level

kidney glomerulus volume
type: Class
subclass of: kidney glomerulus morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-12T15:00:11Z
def: Measurement of the size of the three dimensional space occupied by a single kidney glomerulus.

absolute diurnal change in systolic blood pressure
type: Class
subclass of: absolute change in systolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-24T12:45:12Z
def: Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time, one during the day and the other at night, expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity.
has related synonym: absolute circadian change in systolic blood pressure
has related synonym: systolic diurnal amplitude
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

blood cholesterol level
type: Class
subclass of: blood sterol level
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-24T13:34:25Z
def: The amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, in a specified sample of blood. Cholesterol in the blood is generally associated with various lipoproteins.
has related synonym: Not4Curation

serum cholesterol level
type: Class
subclass of: serum sterol level
subclass of: blood cholesterol level
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-24T13:36:35Z
def: The amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Cholesterol in the serum is associated with various lipoproteins.
has related synonym: Not4Curation

change in mean arterial blood pressure to change in vasoactive chemical dose ratio
type: Class
subclass of: mean arterial blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-28T12:01:46Z
def: A calculated measurement in which difference in the mean arterial blood pressure between two or more dosages of a drug or chemical which reduces or increases the interior diameter of blood vessels is divided by difference the applied dosages and presented as a ratio, fraction, quotient or percentage. The value is calculated as the slope of the curve of the mean arterial blood pressure versus the chemical dose graph.
has related synonym: beta coefficient of mean arterial blood pressure change
has related synonym: change in MAP to change in [vasoactive chemical] ratio
has related synonym: slope of the change in mean arterial blood pressure

artery wall thickness to artery total diameter ratio
type: Class
subclass of: calculated artery wall thickness measurement
subclass of: calculated artery lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-03-28T16:44:54Z
def: Ratio of the wall thickness (WT) of an artery to outer diameter (OD) of that artery at that location, usually expressed as a percentage, i.e. WT/OD x 100, but could also be expressed as a ratio, fraction or quotient. This measurement can be used to assess stenosis, a pathological narrowing of a blood vessel.
has related synonym: arterial stenosis measurement
has related synonym: artery wall thickness as percentage of artery outer diameter
has related synonym: artery wall thickness as percentage of artery total diameter

white blood cell measurement
type: Class
subclass of: blood cell measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-04-24T12:47:44Z
def: Any value resulting from the quantification of a morphological or physiological parameter of leukocytes, largely colorless blood corpuscles capable of ameboid movement, whose chief function is to protect the body against microorganisms and other disease-causing entities.
has exact synonym: leukocyte measurement

blood differential leukocyte count to total leukocyte count ratio
type: Class
subclass of: calculated differential white blood cell count
imported from: cmo.owl
created by: JSmith
creation date: 2014-05-13T18:19:12Z
def: A calculated measurement in which the number of white blood cells of one or more specific types in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
has related synonym: Not4Curation
has related synonym: blood differential leukocyte count to total WBC count ratio
has related synonym: blood differential leukocyte count as percentage of total white blood cells
has related synonym: differential white blood cell percentage

calculated kidney non-tumorous lesion measurement
type: Class
subclass of: kidney non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-05-27T13:59:17Z
def: Any measurement which has been normalized, adjusted or derived by a mathematical process or computation, of a morphological or physiological parameter of non-neoplastic lesions in the kidney.
has related synonym: Not4Curation
has related synonym: calculated renal non-tumorous lesion measurement

ratio of the area occupied by protein casts to the total area of the kidney outer medulla outer stripe and cortex
type: Class
subclass of: calculated kidney non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-05-27T14:01:07Z
def: A calculated measurement in which the area occupied by renal protein casts is divided by the total, combined area of the outer stripe of the kidney outer medulla and the kidney cortex, and the result presented as a ratio, fraction, quotient or percentage. Renal protein casts are gelled proteins precipitated in the renal tubules and molded to the tubular lumen. The medulla outer stripe is the section of the renal medula adjacent to the renal cortex and contains portions of the nephron, including the straight proximal tubules, and portions of the loops of henle and outer medullary collecting ducts.
has related synonym: percent area of renal protein casting

heart wet weight to body weight ratio
type: Class
subclass of: heart wet weight
subclass of: heart weight to body weight ratio
imported from: cmo.owl
created by: JSmith
creation date: 2014-05-28T15:22:49Z
def: A calculated value in which the weight of the heart after removal from the body but without dessication is divided by the total weight of the body, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism.
has related synonym: heart wet weight as a percentage of body weight

vasoconstrictor-induced blood vessel contractile force expressed as percent of force at baseline
type: Class
subclass of: calculated blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T17:16:49Z
def: A calculated measurement in which the difference between the contractile force of a blood vessel in response to a vasoconstrictor and the baseline contractile force exerted by that vessel in the absence of any external stimuli, is divided by the baseline contractile force measurement and the result expressed as a percentage. A vasoconstrictor is any agent or condition that narrows blood vessels by constricting the smooth muscle in the vessel walls.

phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline
type: Class
subclass of: phenylephrine response/sensitivity measurement
subclass of: vasoconstrictor-induced blood vessel contractile force expressed as percent of force at baseline
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T17:21:51Z
def: A calculated measurement in which the difference between the contractile force of a blood vessel in response to a specified dosage of phenylephrine and the baseline contractile force exerted by that vessel in the absence of any external stimuli, is divided by the baseline contractile force measurement and the result expressed as a percentage. Phenylephrine is an adrenergic drug that is a powerful vasoconstrictor.
has related synonym: phenylephrine-induced blood vessel constriction expressed as percent of force at baseline

potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline
type: Class
subclass of: vasoconstrictor-induced blood vessel contractile force expressed as percent of force at baseline
subclass of: potassium chloride response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T17:30:04Z
def: A calculated measurement in which the difference between the contractile force of a blood vessel in response to a specified dosage of potassium chloride and the baseline contractile force exerted by that vessel in the absence of any external stimuli, is divided by the baseline contractile force measurement and the result expressed as a percentage. Potassium chloride is the salt of the potassium cation (K+) and the chlorine/chloride anion (Cl-). It is used as an eletroylyte replenisher and has mild vasoconstrictive properties when applied directly to blood vessels.
has related synonym: KCl-induced blood vessel constriction expressed as percent of force at baseline
xref: CHEBI_32588

potassium chloride response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T18:11:50Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to potassium chloride, the salt of the potassium cation (K+) and the chlorine/chloride anion (Cl-). Potassium chloride is used as an eletroylyte replenisher and has mild vasoconstrictive properties when applied directly to blood vessels.
has related synonym: KCl response/sensitivity measurement
xref: CHEBI_32588

concentration of potassium chloride at which the force of blood vessel contraction is half the maximum value (EC50)
type: Class
subclass of: potassium chloride response/sensitivity measurement
subclass of: concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50)
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T18:19:26Z
def: A calculated value for the concentration of potassium chloride (KCl) at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of KCl is halfway between the baseline value and the highest achievable value of such KCl-induced contractile energy. Potassium chloride is the salt of the potassium cation (K+) and the chlorine/chloride anion (Cl-). It is used as an eletroylyte replenisher and has mild vasoconstrictive properties when applied directly to blood vessels.
has exact synonym: potassium chloride half maximal effective concentration (EC50)
has related synonym: KCl half maximal effective concentration (EC50)
xref: CHEBI_32588

logarithm of the concentration of potassium chloride at which the force of blood vessel contraction is half the maximum value (Log EC50)
type: Class
subclass of: potassium chloride response/sensitivity measurement
subclass of: logarithm of the concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (Log EC50)
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T18:28:02Z
def: A calculated value for logarithm of the concentration of potassium chloride (KCl) at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of KCl is halfway between the baseline value and the highest achievable value of such KCl-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
has exact synonym: potassium chloride Log half maximal effective concentration (Log EC50)
has related synonym: KCl Log half maximal effective concentration (Log EC50)
xref: CHEBI_32588

concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50)
type: Class
subclass of: calculated blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T18:33:14Z
def: A calculated value for the concentration of a vasoconstrictor at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of the stimulus is halfway between the baseline value and the highest achievable value of such stimulus-induced contractile energy. A vasoconstrictor is any agent or condition that narrows blood vessels by constricting the smooth muscle in the vessel walls.
has exact synonym: vasoconstrictor half maximal effective concentration (EC50)

logarithm of the concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (Log EC50)
type: Class
subclass of: calculated blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-09T18:47:36Z
def: A calculated value for logarithm of the concentration of a vasoconstrictor at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of the stimulus is halfway between the baseline value and the highest achievable value of such stimulus-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value. A vasoconstrictor is any agent or condition that narrows blood vessels by constricting the smooth muscle in the vessel walls.
has exact synonym: vasoconstrictor Log half maximal effective concentration (Log EC50)

heart left ventricle end-diastolic anterior wall thickness
type: Class
subclass of: heart left ventricle anterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-24T10:28:27Z
def: The thickness or depth of the ventral/anterior wall of the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed. The ventral/anterior wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism.
has exact synonym: heart left ventricle end-diastolic ventral wall thickness
has related synonym: LVAWd

heart left ventricle weight to heart left ventricle end-diastolic area ratio
type: Class
subclass of: calculated heart left ventricle weight
subclass of: heart left ventricle end-diastolic area
imported from: cmo.owl
created by: JSmith
creation date: 2014-06-24T10:38:32Z
def: A calculated measurement in which the weight of the left ventricle of the heart is divided by its area at end-diastole, that is, when the heart muscle is maximally relaxed, and the result presented as a ratio, fraction, quotient or percentage.

heart blood flow measurement
type: Class
subclass of: circulation measurement
subclass of: heart measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-07-01T11:15:11Z
def: Any measurement of the movement of blood into, through or out of the heart.

E wave velocity
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-07-01T11:21:13Z
def: Measurement of the speed at which blood flows into the ventricle during passive filling, that is, during the period when the blood flows from the atrium to the ventricle due to gravity rather than as a result of active contraction of the atrium.

E wave deceleration time
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-07-01T11:23:06Z
def: An echocardiographic measurement of the amount of time between the maximum 'E point', that is, the maximum velocity of passive blood flow from the atrium to the ventricle, and the return to baseline at the end of early mitral flow.
has related synonym: DT
has related synonym: EDT

E wave deceleration rate
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-07-01T11:26:09Z
def: Measurement of the decrease in transmitral blood flow velocity per unit time or the rate at which the velocity of passive blood flow from the atrium to the ventricle decreases over time as the ventricle fills and the atrium empties, calculated as the slope of transmitral velocity vs time.
has related synonym: EDR

muscle fiber morphological measurement
type: Class
subclass of: muscle morphological measurement
subclass of: muscle measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-05T16:41:32Z
def: Any measurement of the physical form or structure of a muscle fiber, any of the cells of skeletal or cardiac muscle tissue. Each cell is one fiber of the muscle.

skeletal muscle fiber morphological measurement
type: Class
subclass of: muscle morphological measurement
subclass of: muscle fiber morphological measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-05T16:42:27Z
def: Any measurementof the physical form or structure of a skeletal muscle fiber, a cylindrical multinucleate cell of skeletal muscle tissue containing contracting myofibrils and across which run transverse striations.

number of capillaries per skeletal muscle fiber
type: Class
subclass of: skeletal muscle fiber morphological measurement
subclass of: capillary measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-05T16:43:25Z
def: The average number of capillaries associated with and/or surrounding an individual skeletal muscle fiber, a cylindrical multinucleate cell of skeletal muscle tissue containing contracting myofibrils and across which run transverse striations. Capillaries are the minute vessels connecting arterioles and venules, the walls of which act as a semipermeable membrane for interchange of various substances between the blood and tissue fluid.
has related synonym: number of capillaries per skeletal muscle cell

capillary measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-05T16:46:26Z
def: Any measurement, morphological or physiological of the minute vessels connecting arterioles and venules, the walls of which act as a semipermeable membrane for interchange of various substances between the blood and tissue fluid.

left ventricular isovolumetric relaxation time
type: Class
subclass of: heart isovolumetric relaxation time
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-06T10:31:27Z
def: The length of time in the cardiac cycle between the end of left ventricular relaxation and the start of left ventricular filling. This represents the time in the cardiac cycle between closure of the aortic valve and opening of the mitral valve.
has exact synonym: time constant of isovolumetric LV fall
has related synonym: LV-IVRT

left ventricular isovolumetric contraction time
type: Class
subclass of: ventricle contraction measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-06T10:46:35Z
def: The time interval from the completion of the mitral valve closure to the beginning of the aortic valve opening, that is, the period of contraction during which both the mitral and aortic valves are closed so that the volume of the ventricular space doesn't change.

right ventricular isovolumetric relaxation time
type: Class
subclass of: heart isovolumetric relaxation time
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T11:44:51Z
def: The length of time in the cardiac cycle between the end of right ventricular relaxation and the start of right ventricular filling.
has related synonym: RV-IVRT

calculated left ventricular isovolumetric relaxation time
type: Class
subclass of: left ventricular isovolumetric relaxation time
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T11:59:50Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the length of time in the cardiac cycle between the end of left ventricular relaxation and the start of left ventricular filling.
has related synonym: calculated LV-IVRT

heart rate-corrected left ventricular isovolumetric relaxation time
type: Class
subclass of: calculated left ventricular isovolumetric relaxation time
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T12:04:19Z
def: A calculated measurement in which the value of the left ventricular isovolumetric relaxation time is corrected by the square root of the R-R interval [IVRT/(RR)1/2] on a simultaneously-recorded ECG.

mitral valve closure to opening time
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T12:19:05Z
def: Measurement of the length of time between the closing of the mitral valve (the dual-flap valve in the heart that controls blood flow between the left atrium and the left ventricle) at the end of ventricular filling (that is, after atrial contraction) and its opening at the beginning of the next round of ventricular filling.
has related synonym: MV co

left ventricular ejection time
type: Class
subclass of: ventricle contraction measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T13:27:39Z
def: The time interval from the opening to the closing of the aortic valve (mechanical systole).
has related synonym: LVET

myocardial performance index
type: Class
subclass of: left ventricular isovolumetric contraction time
subclass of: calculated left ventricular isovolumetric relaxation time
subclass of: left ventricular ejection time
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T13:54:20Z
def: A calculated measurement comprised of the sum of left ventricular isovolumetric contraction time and isovolumetric relaxation time divided by the left ventricular ejection time.
has related synonym: MPI
has related synonym: TEI-Doppler index

cardiovascular disease severity measurement
type: Class
subclass of: clinical measurement
subclass of: cardiovascular disease measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T14:05:03Z
def: Any measurement of the degree to which the presentation of any cardiovascular disease state, causes pain or damage, or interferes with the normal functioning of an organism or of any part thereof.

cardiovascular disease measurement
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T14:20:49Z
def: Any measurement related to a deviation from or interruption of the normal structure or function of the cardiovascular system that is manifested by a characteristic set of symptoms and signs.

arterial disease severity measurement
type: Class
subclass of: cardiovascular disease severity measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T14:23:23Z
def: Any measurement of the degree to which the presentation of an arterial disease state, causes pain or damage, or interferes with the normal functioning of an organism or of any part thereof. Arterial disease is a deviation from or interruption of the normal structure or function of one or more arteries, the vessels in which blood flows away from the heart carrying oxygenated blood, that is manifested by a characteristic set of symptoms and signs.

aortic rupture severity measurement
type: Class
subclass of: arterial disease severity measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T15:16:50Z
def: Measurement of the degree to which a tear or break in the continuity or configuration of the aorta (the great artery arising from the left ventricle and from which the systemic arterial system proceeds) causes pain or damage, or interferes with the normal functioning of an organism or of any part thereof.

number of ruptures of arterial internal elastic lamina
type: Class
subclass of: arterial disease severity measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T15:33:42Z
def: The value or quantity determined by count of tears or breaks in the continuity or configuration of the fenestrated layer of elastic tissue that is the outermost part of the intima of an artery.
has exact synonym: number of ruptures of internal elastic lamina in arteries
has exact synonym: number of ruptures of internal elastic laminae in arteries
has related synonym: number of RIEL in arteries
has related synonym: number of ruptures of arterial IEL

number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries
type: Class
subclass of: number of ruptures of arterial internal elastic lamina
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T15:35:18Z
def: The value or quantity determined by count of tears or breaks in the continuity or configuration of the internal elastic lamina (IEL) of the abdominal aorta and iliac arteries, that is, the distal segment of the descending aorta and the large arteries that originate from it.
has related synonym: number of AA- and IA-RIEL
has related synonym: number of RIEL in abdominal aorta and iliac arteries

number of ruptures of the internal elastic lamina of the renal arteries
type: Class
subclass of: number of ruptures of arterial internal elastic lamina
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T15:47:20Z
def: The value or quantity determined by count of tears or breaks in the continuity or configuration of the internal elastic lamina (IEL) of the renal arteries, that is, the ateries which arise from the side of the abdominal aorta and which supply the kidneys with blood.
has related synonym: number of RIEL in renal arteries

arterial internal elastic lamina rupture composite score
type: Class
subclass of: arterial disease severity measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T15:50:34Z
def: A measurement of the severity of tears or breaks in the arterial internal elastic lamina (IEL) which is derived from a combination of multiple measurements and/or objective or subjective severity scores according to a specified formula or set of criteria. The IEL is the fenestrated layer of elastic tissue that is the outermost part of the intima of an artery.
has related synonym: arterial RIEL score

aorta wall extracellular elastin dry weight to aorta length ratio
type: Class
subclass of: aorta wall extracellular elastin level
subclass of: calculated aorta wall molecular composition measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T18:42:12Z
def: A calculated measurement in which the weight after dessication of the extracellular elastin in a specified sample of the wall of the aorta is divided by the length (that is, the distance between the two ends) of that segment, and the result presented as a ratio, fraction, quotient or percentage.

patent ductus arteriosus score
type: Class
subclass of: arterial disease severity measurement
imported from: cmo.owl
created by: JSMITH
creation date: 2014-08-18T18:54:19Z
def: A measurement of the existance and severity of a patent ductus arteriosus (PDA) when such a measurement is derived from a combination of multiple measurements and/or an objective or subjective ranking or rating system according to a specified formula or set of criteria. PDA is the abnormal persistence of an open lumen in the ductus arteriosus, between the aorta and the pulmonary artery, after birth.
has related synonym: PDA score
has related synonym: score for PDA

tissue protein/peptide composition measurement
type: Class
subclass of: tissue molecular composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-08-26T13:32:08Z
def: Any measurement involving the composition, that is, the absolute amount, relative amount or type of one or more proteins (complex high molecular weight organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) or peptides (low molecular weight compounds composed of at least two amino acids joined by peptide linkages) in a specified tissue or set of tissues.

aorta wall protein/peptide composition measurement
type: Class
subclass of: aorta wall molecular composition measurement
subclass of: tissue protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2014-08-26T13:35:55Z
def: Any measurement involving the composition, that is, the absolute amount, relative amount or type of one or more proteins or peptides in a specified sample of tissue from the wall of the aorta.
has exact synonym: aortic wall protein/peptide composition measurement

blood pressure time series calculated parameter
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T17:13:44Z
def: A calculated parameter derived from a a sequence of blood pressure measurements taken sequentially and ordered in time. A parameter is a mathematical and statistical variable in a model system that partially or completely characterises the mathematical model.

blood pressure time series baroreceptor response calculation parameter
type: Class
subclass of: blood pressure time series calculated parameter
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T18:09:25Z
def: A mathematical and statistical variable in a model system that partially or completely characterises the baroreceptor response in a blood pressure time series calculation. The baroreceptor response is the system whereby specific nerve terminals that stabilize moment to moment blood pressure variability in the carotid sinus and aortic arch sense deviations from the baseline pressure and initiate signals that dampens such deviations.

blood pressure time series first order moving average coefficient
type: Class
subclass of: blood pressure time series calculated parameter
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T18:10:33Z
def: The first order coefficient parameter derived from a blood pressure time series moving average (also known as a rolling average, running average, moving mean, or rolling mean) calculation.

blood pressure time series fractal parameter
type: Class
subclass of: blood pressure time series calculated parameter
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T18:24:22Z
def: The fractal parameter derived from a blood pressure time series calculation based on a autoregressive fractionally integrated moving average time series model (ARFIMA, FARIMA, or fARIMA).

blood pressure time series experimental set point of the baroreceptor response
type: Class
subclass of: blood pressure time series baroreceptor response calculation parameter
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T18:26:20Z
def: The experimental set point parameter of the blood pressure time series baroreceptor response calculation.

blood pressure time series average exponential scaling factor of the baroreceptor response
type: Class
subclass of: blood pressure time series baroreceptor response calculation parameter
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T18:28:14Z
def: The average exponential scaling factor parameter of the blood pressure time series baroreceptor response calculation.

blood pressure time series linear term first order parameter
type: Class
subclass of: blood pressure time series calculated parameter
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T18:33:18Z
def: A parameter based on a blood pressure time series calculation using a first order mechanistic model.

blood pressure time series linear term second order parameter
type: Class
subclass of: blood pressure time series calculated parameter
imported from: cmo.owl
created by: JSmith
creation date: 2014-09-11T18:33:53Z
def: A parameter based on a blood pressure time series calculation using a second order mechanistic model.

heart left ventricle end-diastolic posterior wall thickness
type: Class
subclass of: heart left ventricle posterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2014-10-29T10:36:08Z
def: The thickness or depth (i.e. the measurement of the two-dimensional extent of the distance between the inner and outer surfaces) of the dorsal/posterior wall of the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism.
has exact synonym: end-diastolic heart left ventricle posterior wall thickness
has related synonym: end-diastolic heart left ventricle PWT
comment: Note that "left" in this context refers to the perspective of the organism, not that of the observer.

blood lipoprotein measurement
type: Class
subclass of: blood protein measurement
subclass of: blood lipid measurement
imported from: cmo.owl
created by: jesmith
creation date: 2015-12-03T15:18:18Z
def: A value resulting from the quantification of a morphological or physiological parameter of a blood-derived lipoprotein, any of a class of complex molecules found in blood that consist of a protein membrane surrounding a core of lipids.

blood lipoprotein cholesterol level
type: Class
subclass of: blood lipoprotein level
subclass of: blood cholesterol level
imported from: cmo.owl
created by: jesmith
creation date: 2015-12-03T15:41:10Z
def: Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in lipoprotein molecules in a specified volume of blood. Lipoprotein particles are complex molecules that consist of a protein membrane surrounding a core of lipids.

aorta length
type: Class
subclass of: aorta morphological measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-02-22T13:08:55Z
def: The distance between the two ends, that is, of the extent of the longest dimension, of the aorta, the main trunk from which the arterial system proceeds.

calculated aorta morphological measurement
type: Class
subclass of: aorta morphological measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-02-22T13:12:37Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the physical form or structure of the aorta, the main trunk from which the arterial system proceeds.

aorta weight to aorta length to body weight ratio
type: Class
subclass of: calculated aorta morphological measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-02-22T13:14:54Z
def: A calculated measurement in which the weight of the aorta is divided by its length and the resulting quantity is divided by the total body weight of the organism.
has related synonym: Am/AI/Bm
has related synonym: aorta mass to aorta length to body mass ratio

percent change in pulse pressure
type: Class
subclass of: pulse pressure
imported from: cmo.owl
created by: jesmith
creation date: 2017-02-22T13:28:13Z
def: A calculated measurement of the relative difference in pulse pressure between a treated state and a control state or between two points in time, expressed as a percentage.

heart protein activity measurement
type: Class
subclass of: heart measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-19T12:56:36Z
def: Any quantification of the ability of a protein of the heart to accomplish an effect, e.g. take part in a chemical reaction or carry out a specified molecular function.

heart enzyme activity level
type: Class
subclass of: heart protein activity measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-19T13:02:57Z
def: Any quantification of the ability of a heart enzyme, i.e. a protein located in the heart that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions, to carry out its specified molecular function.

heart angiotensin I converting enzyme 2 activity level
type: Class
subclass of: heart enzyme activity level
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-19T13:04:34Z
def: Quantitation of the catalytic effect exerted by angiotensin I converting enzyme 2 (ACE2) in a specified sample of heart tissue. ACE2, an ACE homolog, is a zinc-dependent peptidase of the M2-metalloprotease family that is sensitive to chloride ion concentration, is a membrane-bound enzyme that acts as a monocarboxypeptidase, and is an essential regulator of heart function.
has related synonym: heart ACE2 activity level
has related synonym: heart angiotensin II converting enzyme activity level

heart angiotensin I converting enzyme activity level
type: Class
subclass of: heart enzyme activity level
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-19T13:05:42Z
def: Quantitation of the catalytic effect exerted by angiotensin I converting enzyme (ACE) in a specified sample of heart tissue. ACE is one of the enzymes of the renin-angiotensin system, and catalyzes the conversion of angiotensin I into a physiologically active vasoconstrictor peptide angiotensin II.
has related synonym: heart ACE activity level

kidney angiotensin I converting enzyme 2 activity level
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-20T10:00:38Z
def: Quantitation of the catalytic effect exerted by angiotensin converting enzyme2 (ACE2) in a specified sample of kidney. ACE2, an ACE homolog, is a zinc-dependent peptidase of the M2-metalloprotease family that is sensitive to chloride ion concentration, and is a membrane-bound enzyme that acts as a monocarboxypeptidase and is an essential regulator of heart function.
has related synonym: kidney ACE2 activity level
has related synonym: kidney angiotensin II converting enzyme activity level

kidney angiotensin I converting enzyme activity level
type: Class
subclass of: kidney enzyme activity measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-20T10:01:18Z
def: Quantitation of the catalytic effect exerted by angiotensin I converting enzyme (ACE) in a specified sample of kidney tissue. ACE is one of the enzymes of the renin-angiotensin system, and catalyzes the conversion of angiotensin I into a physiologically active vasoconstrictor peptide angiotensin II.
has related synonym: kidney ACE activity level

cardiac muscle fiber morphological measurement
type: Class
subclass of: heart morphological measurement
subclass of: muscle fiber morphological measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-20T13:40:53Z
def: Any measurement of the physical form or structure of a cardiac muscle fiber, a striated cardiac muscle cell (cardiomyocyte) that is responsible for heart contraction.
has exact synonym: cardiac muscle cell morphological measurement
has exact synonym: cardiac myocyte morphological measurement
has exact synonym: cardiomyocyte morphological measurement
has exact synonym: heart muscle cell morphological measurement
has related synonym: cardiocyte morphological measurement

cardiac muscle fiber diameter
type: Class
subclass of: cardiac muscle fiber morphological measurement
imported from: cmo.owl
created by: jesmith
creation date: 2017-07-20T13:43:26Z
def: The length of a straight line passing through a cardiac muscle fiber, that is a cardiomyocyte, for instance through the center of its nucleus, and connecting opposite points on its periphery.
has exact synonym: cardiac myocyte diameter
has exact synonym: cardiomyocyte diameter
has exact synonym: heart muscle cell diameter
has related synonym: cardiocyte diameter
has related synonym: cardiomyocyte width

renal plasma flow to body weight ratio
type: Class
subclass of: calculated renal plasma flow
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-03T09:34:26Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the amount of plasma that perfuses the kidneys per unit time per amount of body weight.

glomerular filtration rate to body weight ratio
type: Class
subclass of: calculated glomerular filtration rate
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-03T17:41:50Z
def: A calculated measurement in which glomerular filtration rate, an estimate of the volume of fluid filtered from the kidney glomerular capillaries into the Bowman's capsule per specified unit of time, is divided by the total weight of the body and the result is presented as a ratio, fraction, quotient or percentage.

kidney sclerotic glomerular volume to total kidney glomerular volume ratio
type: Class
subclass of: calculated kidney glomerulosclerotic lesion measurement
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-11T12:56:54Z
def: A calculated value in which the volume of glomeruli with lesions resulting from fibrosis, scarring or hyaline deposits is divided by the total volume of glomeruli in a specified sample of kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total volume of glomeruli.

heart left ventricle weight to tibia length ratio
type: Class
subclass of: calculated heart left ventricle weight
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-15T16:59:53Z
def: A calculated value in which the weight of the heart left ventricle is divided by the length of the tibia (the medial and larger of the two bones of the lower leg of bipeds or hindlimb of quadrupeds which articulates with the femur, fibula, and talus), and the result is presented as a ratio, fraction, quotient or percentage,thus normalizing it to the length of the leg and, by extension, to the size of the body.
has exact synonym: LV weight/tibial length

calculated heart blood flow measurement
type: Class
subclass of: calculated blood flow measurement
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-15T17:02:51Z
def: Any measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the movement of blood into, through or out of the heart.

E/A wave ratio
type: Class
subclass of: calculated heart blood flow measurement
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-15T17:05:23Z
def: A calculated measurement in which the value of the E wave (that is, the velocity of the blood flow across the mitral valve during passive filling of the left ventricle in early diastole) is divided by the value of the A wave (that is, the velocity of the blood flow across the mitral valve during active filling of the left ventricle caused by atrial contraction in late diastole).
has related synonym: mitral E/A wave ratio

artery tunica media width to artery inner diameter ratio
type: Class
subclass of: calculated artery wall thickness measurement
subclass of: artery tunica media measurement
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-15T17:08:42Z
def: A calculated measurement in which the average width of the tunica media is divided by the inner diameter (that is, the diameter of the lumen) of the artery and the result is presented as a ratio, fraction, quotient or percentage.

heart intraventricular end-diastolic wall thickness
type: Class
subclass of: heart ventricle septal wall thickness
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-15T17:12:15Z
def: The thickness, width or depth of the septal wall of the heart ventricles (that is, the portion of the wall between the left and right ventricles that is shared between the two) at the end of diastole when the heart muscle is maximally relaxed.
has exact synonym: heart intraventricular septum end-diastolic thickness
has related synonym: IVSd

heart intraventricular end-systolic wall thickness
type: Class
subclass of: heart ventricle septal wall thickness
imported from: cmo.owl
created by: jrsmith
creation date: 2018-05-15T17:13:43Z
def: The thickness, width or depth of the septal wall of the heart ventricles (that is, the portion of the wall between the left and right ventricles that is shared between the two) at the end of systole when the heart muscle is maximally contracted.
has exact synonym: heart intraventricular septum end-systolic thickness
has related synonym: IVSs

systolic blood pressure variability
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-13T15:00:11Z
def: A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour systolic blood pressure measurements.

diastolic blood pressure variability
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-13T15:02:20Z
def: A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour diastolic blood pressure measurements.

mean arterial blood pressure variability
type: Class
subclass of: mean arterial blood pressure
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-13T15:04:28Z
def: A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour mean arterial blood pressure measurements.

heart rate variability
type: Class
subclass of: calculated heart rate measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-13T15:12:25Z
def: A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour heart rate measurements.

ratio of number of glomeruli with microaneurysms to number of total glomeruli
type: Class
subclass of: calculated kidney non-tumorous lesion measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-14T10:49:02Z
def: A calculated value in which the number of glomeruli with microaneurysm (focal dilation of arteriocapillary junctions), is divided by the total number of glomeruli in the kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total number of glomeruli.

ratio of glomerular area occupied by activated mesangial cells to total glomerular area
type: Class
subclass of: calculated kidney glomerulus measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-14T11:16:40Z
def: A calculated value in which the area of glomeruli with activated mesangial cells (determined by the expression of α-smooth muscle actin), is divided by the total area of glomeruli counted in the kidney and presented as a ratio, fraction or quotient, thus normalizing it to the total number of glomeruli.

calculated kidney glomerulus measurement
type: Class
subclass of: kidney glomerulus morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-14T11:19:47Z
def: Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the glomeruli of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has exact synonym: calculated kidney glomerulus morphological measurement

mesenteric artery morphological measurement
type: Class
subclass of: blood vessel morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-19T15:28:14Z
def: Any measurement of the physical form or structure of one or more of the mesenteric arteries, which arise from the anterior surface of the abdominal aorta, just inferior to the origin of the celiac trunk, and supplies blood to the intestine from the lower part of the duodenum through two-thirds of the transverse colon, as well as the pancreas.

mesenteric artery molecular composition measurement
type: Class
subclass of: tissue molecular composition measurement
subclass of: mesenteric artery morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-19T15:30:34Z
def: Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the wall of one or more of the mesenteric arteries.

calculated mesenteric artery molecular composition measurement
type: Class
subclass of: mesenteric artery molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-19T15:33:20Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation of the physical form or structure of any of the mesenteric arteries.
has exact synonym: calculated mesenteric artery wall molecular composition measurement

mesenteric artery phosphylated eNOS level to total eNOS level ratio
type: Class
subclass of: calculated mesenteric artery molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-19T15:35:54Z
def: A calculated measurement in which mesenteric artery phosphorylated eNOS protein level is divided by aorta wall total eNOS protein level and presented as a ratio, fraction, quotient or percentage. Phosphorylation of eNOS is a mechanism that catylzes a structural change of the enzyme to an activated form.
has exact synonym: mesenteric artery phosphylated eNOS protein level to total eNOS protein level ratio
has exact synonym: mesenteric artery wall phosphylated eNOS level to total eNOS level ratio

aorta wall phosphylated eNOS level to total eNOS level ratio
type: Class
subclass of: calculated aorta wall molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-19T15:53:29Z
def: A calculated measurement in which aorta wall phosphorylated eNOS protein level is divided by aorta wall total eNOS protein level and presented as a ratio, fraction, quotient or percentage. Phosphorylation of eNOS is a mechanism that catylzes a structural change of the enzyme to an activated form.
has exact synonym: aorta wall phosphylated eNOS protein level to total eNOS protein level ratio

Monophasic action potential
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T13:03:49Z
def: Monophasic action potentials (MAPs) are recorded using contact electrode catheters. The recordings provide local information about the actual cellular depolarization and repolarization process of myocardial tissue. They are different from body surface electrocardiographic (ECG) recordings or standard endocardial electrograms, which produce a summative or derivative view of the heart's electrical activity

Conduction velocity
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T13:39:11Z
def: Conduction velocity is calculated as the distance from pacing electrode to the monophasic action potential recording electrode across the epicardial surface, divided by the conduction time, the time from the pacing spike to monophasic action potential onset.

E/E' wave ratio
type: Class
subclass of: calculated heart blood flow measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T14:10:18Z
def: The E/E' is a ratio of peak velocity of early diastolic trans-mitral flow (E) to the peak velocity of early diastolic mitral annular motion (E')
has related synonym: E wave velocity to E' wave velocity ratio

heart molecular composition measurement
type: Class
subclass of: heart morphological measurement
subclass of: tissue molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T14:27:05Z
def: Any quantitation of the molecules, atoms and/or ions which constitute the chemical make-up of the tissue(s) of the heart.
has exact synonym: cardiac molecular composition measurement

heart free fatty acid level
type: Class
subclass of: heart molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T14:31:33Z
def: Measurement of the amount of free fatty acids within the heart.
has exact synonym: cardiac free fatty acid level
has exact synonym: cardiac non-esterified fatty acid level
has exact synonym: heart NEFA level
has exact synonym: heart non-esterified fatty acid level

heart triglyceride level
type: Class
subclass of: heart molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T14:35:50Z
def: Measurement of the amount of triglycerides within the heart.
has exact synonym: cardiac triglyceride level

calculated heart left ventricle end-systolic posterior wall thickness
type: Class
subclass of: heart left ventricle end-diastolic posterior wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T14:44:30Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the end-systolic heart left ventricle posterior wall thickness.

heart left ventricle end-systolic posterior wall index
type: Class
subclass of: calculated heart left ventricle end-systolic posterior wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T14:50:07Z
def: A calculated measurement in which the heart left ventricle end-systolic posterior wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.

calculated heart left ventricle end-systolic internal diameter
type: Class
subclass of: calculated heart left ventricle morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T14:59:27Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart left ventricle end-systolic internal diameter.
has exact synonym: calculated heart left ventricle end-systolic internal dimension

heart left ventricle end-systolic internal diameter index
type: Class
subclass of: calculated heart left ventricle end-systolic internal diameter
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T15:03:09Z
def: A calculated measurement in which the heart left ventricle end-systolic internal diameter is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.
has exact synonym: heart left ventricle end-systolic internal dimension index

calculated heart ventricle end-systolic septal wall thickness
type: Class
subclass of: heart intraventricular end-systolic wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T15:08:05Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart ventricle end-systolic septal wall thickness.
has exact synonym: calculated heart end-systolic intraventricular wall thickness

heart ventricle end-systolic septal wall index
type: Class
subclass of: calculated heart ventricle end-systolic septal wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T15:11:20Z
def: A calculated measurement in which the heart ventricle end-systolic septal wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.

A wave velocity
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T15:13:54Z
def: Peak velocity of late atrial diastolic trans-mitral flow (A).

E' wave velocity
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T15:20:51Z
def: E' wave velocity is the peak velocity of early mitral annular diastolic motion.
has exact synonym: e' wave velocity

A' wave velocity
type: Class
subclass of: heart blood flow measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-26T15:23:27Z
def: A' wave velocity (A') is the peak velocity of late (atrial) diastolic mitral annular motion.
has exact synonym: a' wave velocity

calculated cardiac output measurement
type: Class
subclass of: cardiac output measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:03:00Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of cardiac output.

cardiac index
type: Class
subclass of: calculated cardiac output measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:09:41Z
def: A calculated measurement in which the cardiac output is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.

calculated stroke volume
type: Class
subclass of: stroke volume
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:14:24Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of cardiac stroke volume.

stroke index
type: Class
subclass of: calculated stroke volume
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:16:25Z
def: A calculated measurement in which the cardiac stroke volume is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.

calculated left ventricular end-systolic blood pressure
type: Class
subclass of: left ventricular end-systolic blood pressure
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:20:50Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the left ventricular end-systolic blood pressure.

arterial elastance
type: Class
subclass of: calculated left ventricular end-systolic blood pressure
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:23:57Z
def: Effective arterial elastance (Ea), defined as the ratio of left ventricular (LV) end-systolic pressure and stroke volume, lumps the steady and pulsatile components of the arterial load in a concise way.

ventricle stroke work
type: Class
subclass of: ventricle contraction measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:29:19Z
def: Defined as the work performed by the left or right ventricle to eject the stroke volume into the aorta or pulmonary artery, respectively.

left ventricle stroke work
type: Class
subclass of: ventricle stroke work
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:32:24Z
def: Defined as the work performed by the left ventricle to eject the stroke volume into the aorta.

preload recruitable left ventricle stroke work
type: Class
subclass of: left ventricle stroke work
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:34:52Z
def: Preload recruitable stroke work (PRSW) is determined by the linear regression of stroke work with the end-diastolic volume. The slope of the PRSW relationship is a highly linear index of myocardial contractility that is insensitive to preload and afterload.

maximum rate of positive change in left ventricular blood pressure to left ventricular end-diastolic volume ratio
type: Class
subclass of: maximum rate of positive change in left ventricular blood pressure
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:38:49Z
def: A calculated measurement in which the maximum rate of positive change in left ventricular blood pressure is divided by the left ventricular end-diastolic volume, and the result presented as a ratio, fraction, quotient or percentage.

calculated heart left ventricle end-diastolic posterior wall thickness
type: Class
subclass of: heart left ventricle end-diastolic posterior wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:46:13Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the end-diastolic heart left ventricle posterior wall thickness.

heart left ventricle end-diastolic posterior wall index
type: Class
subclass of: calculated heart left ventricle end-diastolic posterior wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:56:21Z
def: A calculated measurement in which the heart left ventricle end-diastolic posterior wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.

calculated heart left ventricle end-diastolic anterior wall thickness
type: Class
subclass of: heart left ventricle end-diastolic anterior wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T15:58:19Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart left ventricle end-diastolic anterior wall thickness.

heart left ventricle end-diastolic anterior wall index
type: Class
subclass of: calculated heart left ventricle end-diastolic anterior wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T16:14:56Z
def: A calculated measurement in which the heart left ventricle end-diastolic anterior wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.

calculated heart ventricle end-diastolic septal wall thickness
type: Class
subclass of: heart intraventricular end-diastolic wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T16:18:07Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the heart ventricle end-diastolic septal wall thickness.

heart ventricle end-diastolic septal wall index
type: Class
subclass of: calculated heart ventricle end-diastolic septal wall thickness
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-27T16:19:43Z
def: A calculated measurement in which the heart ventricle end-diastolic septal wall thickness is divided by the weight of the body, and the result presented as a ratio, fraction, quotient or percentage.

renal medullary blood flow rate
type: Class
subclass of: renal blood flow rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-11-30T15:55:22Z
def: Renal medullary blood flow (MBF) is the volume of blood delivered to or exiting from the renal medulla per unit time.

heart left ventricle end-diastolic elastance
type: Class
subclass of: calculated ventricle contraction measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-03T16:21:42Z
def: Left ventricle end-diastolic elastance (Eed) is the estimate of the slope of the line Ped=Eed(Ved-V0), which is based on linear regression of points determined by iterative calculation of the LV end-diastolic pressurevolume relationship.

heart left ventricle end-systolic elastance
type: Class
subclass of: calculated ventricle contraction measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-03T16:24:05Z
def: Left ventricle end-systolic elastance (Ees) is the estimate of the slope of the line Pes=Ees(Ves-V0), which is based on linear regression of points determined by iterative calculation of the LV end-systolic pressurevolume relationship.

calculated ventricle contraction measurement
type: Class
subclass of: ventricle contraction measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-04T12:06:42Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of components of the periodic tightening and loosening of the muscles of a ventricle of the heart.

Heart left ventricle diastolic volume-axis intercept (V0)
type: Class
subclass of: calculated ventricle contraction measurement
subclass of: Calculated endo-diastolic volume
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-04T12:31:25Z
def: Left ventricle diastolic volume-axis intercept (V0) is determined by the line Ped=Eed(Ved-V0), which is based on linear regression of points determined by interative calculation of the LV end-diastolic pressurevolume relationship.

Heart left ventricle systolic volume-axis intercept (V0)
type: Class
subclass of: calculated ventricle contraction measurement
subclass of: Calculated endo-systolic volume
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-04T12:34:18Z
def: Left ventricle systolic volume-axis intercept (V0) is determined by the line Pes=Ees(Ves-V0), which is based on linear regression of points determined by iterative calculation of the LV end-diastolic pressurevolume relationship.

Calculated endo-diastolic volume
type: Class
subclass of: end-diastolic volume
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-04T12:46:20Z
def: A measurement of the volume of blood in ventricle immediately before a contraction which has been normalized or adjusted by a mathematical process or computation. .

Calculated endo-systolic volume
type: Class
subclass of: end-systolic volume
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-04T12:59:56Z
def: A measurement of the volume of blood in a ventricle at the end of a contraction which has been normalized or adjusted by a mathematical process or computation.

kidney adrenomedullin level
type: Class
subclass of: kidney protein/peptide composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-05T13:54:43Z
def: The amount of adrenomedullin in a specified sample of kidney tissue.

kidney medullary adrenomedullin level
type: Class
subclass of: kidney adrenomedullin level
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-05T13:57:39Z
def: The amount of adrenomedullin in a specified sample of medullary kidney tissue.

kidney cortical adrenomedullin level
type: Class
subclass of: kidney adrenomedullin level
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-05T13:59:17Z
def: The amount of adrenomedullin in a specified sample of cortical kidney tissue.

calculated glomerular filtration rate
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T10:37:27Z
def: Any measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the volume of fluid filtered from the kidney glomerular capillaries into the Bowman's capsule per specified unit of time based on serum creatinine level, wieght and age of organism and other factors.

heart nucleic acid measurement
type: Class
subclass of: heart molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T11:57:13Z
def: Any quantification of a morphological or physiological parameter of one or more nucleic acids in the heart. Nucleic acids are high-molecular-weight polymeric compounds composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose or deoxyribose sugar, and a phosphate group, and are involved in the determination and transmission of genetic characteristics.

heart ribonucleic acid composition measurement
type: Class
subclass of: heart nucleic acid measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:02:20Z
def: Any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) of which the heart is formed or composed.

heart insulin-like growth factor 1 mRNA level
type: Class
subclass of: heart ribonucleic acid composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:04:28Z
has exact synonym: heart Igf1 mRNA level

heart left ventricle ribonucleic acid content
type: Class
subclass of: heart left ventricle molecular composition measurement
subclass of: heart ribonucleic acid composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:09:49Z
def: Any measurement of the absolute or relative amount(s) of one or more of the ribonucleic acids (RNAs) of which the heart left ventricle is formed or composed.

heart right ventricle insulin-like growth factor 1 mRNA level
type: Class
subclass of: heart insulin-like growth factor 1 mRNA level
subclass of: heart right ventricle ribonucleic acid content
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:23:27Z

heart right ventricle ribonucleic acid content
type: Class
subclass of: heart ribonucleic acid composition measurement
subclass of: heart right ventricle molecular composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:28:34Z
def: The amount of ribonucleic acid (DNA), the molecule composed of the sugar ribose, phosphate groups and any combination of the bases adenine, guanine, cytosine, and/or uracil , extracted from or contained in the heart right ventricle, the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung.

heart right ventricle molecular composition measurement
type: Class
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:30:31Z

heart left ventricle insulin-like growth factor 1 mRNA level
type: Class
subclass of: heart insulin-like growth factor 1 mRNA level
subclass of: heart left ventricle ribonucleic acid content
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:35:54Z
has exact synonym: heart left ventricle Igf1r mRNA level

heart insulin-like growth factor 1 receptor mRNA level
type: Class
subclass of: heart ribonucleic acid composition measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:44:11Z
has exact synonym: heart Igf1r mRNA level

heart right ventricle insulin-like growth factor 1 receptor mRNA level
type: Class
subclass of: heart right ventricle ribonucleic acid content
subclass of: heart insulin-like growth factor 1 receptor mRNA level
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:46:44Z

heart left ventricle insulin-like growth factor 1 receptor mRNA level
type: Class
subclass of: heart left ventricle ribonucleic acid content
subclass of: heart insulin-like growth factor 1 receptor mRNA level
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T12:49:23Z

renal filtration fraction
type: Class
subclass of: calculated renal plasma flow
subclass of: calculated glomerular filtration rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T14:45:56Z
def: Filtration fraction is the ratio of the glomerular filtration rate (GFR) to the renal plasma flow (RPF). Filtration Fraction, FF = GFR/RPF. The filtration fraction, therefore, represents the proportion of the fluid reaching the kidneys which passes into the renal tubules.
has exact synonym: FF
has exact synonym: filtration fraction

glomerular filtration rate to kidney weight ratio
type: Class
subclass of: calculated glomerular filtration rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T14:51:40Z

single nephron glomerular filtration rate
type: Class
subclass of: calculated glomerular filtration rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T14:54:49Z
def: A calculated measurement to determine the volume of fluid filtered from the renal (kidney) glomerular capillaries of a single nephron into Bowman's capsule per unit time.
has exact synonym: SNGFR

single nephron filtration fraction
type: Class
subclass of: calculated renal plasma flow
subclass of: single nephron glomerular filtration rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T14:57:04Z
def: A calculated measurement to determine the ratio of the single nephron glomerular filtration rate (SNGFR) to the renal plasma flow (RPF). Single nephron filtration Fraction, SNFF = SNGFR/RPF. The single nephron filtration fraction, therefore, represents the proportion of the fluid reaching the kidneys which passes into the renal tubules from a single nephron.
has exact synonym: SNFF

calculated kidney morphological measurement
type: Class
subclass of: kidney morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T15:14:18Z

renal tubulointerstitial score
type: Class
subclass of: calculated kidney morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-07T15:16:47Z
def: ""A semiquantitative evaluation of the renal interstitium using a grading system with a score of 0 to 4+, which assesses the tubules and the interstitium for the presence of (1) tubular atrophy, (2) tubular dilatation, (3) interstitial inflammatory cell infiltrates, and (4) interstitial fibrosis. A score of 0 indicates no lesion (normal kidney), 1+ indicates a single, small focal lesion with very minimal tubular alterations and interstitial inflammatory cell infiltration, and 2+ to 4+ indicated increasing severity of tubular lesions, interstitial inflammatory cell infiltration, and/or fibrosis. A score of 4+ indicates involvement of approximately 50% or more of the renal parenchyma or interstitium." [PMID:PMID\:9369281]
has exact synonym: kidney tubulointerstitial score

heart left atrium weight to body weight ratio
type: Class
subclass of: calculated heart left atrium morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-20T14:50:34Z
def: A calculated value in which the weight of the left atrium, the upper chamber on the left side of the heart which empties into the lower left chamber, is divided by the total weight of the body and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight.

calculated heart right atrium morphological measurement
type: Class
subclass of: heart right atrium morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-20T14:57:33Z
def: A measurement of the physical form or structure of the right atrium, the right upper chamber of the heart that receives blood from the vena cava and forces it into the right ventricle, which has been normalized, adjusted or derived by a mathematical process or computation.

heart right atrium weight to body weight ratio
type: Class
subclass of: calculated heart right atrium morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-20T14:59:58Z
def: A calculated value in which the weight of the right atrium, the upper chamber on the right side of the heart which empties into the lower right left chamber, is divided by the total weight of the body and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight.

Heart septum weight
type: Class
subclass of: heart weight
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-20T15:02:38Z
def: The weight of the septum of the heart, which is the portion of the heart left ventricle ventral/anterior wall and right ventricle dorsal/posterior wall which is shared between the ventricles, after removal from the body and separation from the rest of the heart.

number of podocytes per kidney glomerulus
type: Class
subclass of: kidney glomerulus morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-20T15:09:32Z
def: The average number of podocytes in the kidney glomeruli.

number of podocytes to glomerular volume ratio
type: Class
subclass of: calculated kidney glomerulus measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-20T15:13:54Z
def: A calculated measurement in which the average number of podocytes is divided by the average volume of kidney glomeruli.

number of nucleated cells per kidney glomerulus
type: Class
subclass of: kidney glomerulus morphological measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-26T16:17:20Z
def: The average number of nucleated cells in the kidney glomeruli.

mesangial injury score
type: Class
subclass of: index of glomerular damage
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-26T16:20:07Z
def: An injury score obtained by multiplying the degree of glomerular damage (0 to 4) with the percentage of the glomeruli with that type of injury (i.e., increase in mesangial matrix material or glomerulosclerosis).

glomerular capillary plasma flow rate
type: Class
subclass of: calculated renal plasma flow
subclass of: calculated glomerular filtration rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T11:44:39Z
def: Volume of blood plasma delivered to a single glomerulus per unit time
has exact synonym: Qa

glomerular capillary hydraulic pressure
type: Class
subclass of: capillary measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T11:55:22Z
def: Force exerted on the luminal capillary wall from fluid flowing through the capillary.

arteriole measurement
type: Class
subclass of: artery measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:03:45Z
def: Any measurement of one of the small blood vessels carrying blood between arteries and capillaries.

arteriolar resistance
type: Class
subclass of: blood vessel resistance measurement
subclass of: arteriole measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:07:55Z
def: Resistance that must be overcome to push blood through arterioles to create flow.

efferent arteriolar resistance
type: Class
subclass of: renal vascular resistance
subclass of: arteriolar resistance
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:21:25Z
def: Resistance to blood flow measured within the efferent arteriole proximal to a glomerular capillary network.
has exact synonym: Re
has exact synonym: efferent glomerular arteriolar resistance

afferent arteriolar resistance
type: Class
subclass of: renal vascular resistance
subclass of: arteriolar resistance
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:27:17Z
def: Resistance to blood flow measured within the afferent arteriole distal to a glomerular capillary network.
has exact synonym: Ra
has exact synonym: afferent glomerular arteriolar resistance

total arteriolar resistance
type: Class
subclass of: calculated renal vascular resistance
subclass of: arteriolar resistance
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:33:35Z
def: Total resistance to blood flow measured within the afferent arteriole proximal and distal to a glomerular capillary network (Rt = Ra + Re).
has exact synonym: Rt; total glomerular arteriolar resistance

afferent arteriolar plasma protein concentration
type: Class
subclass of: plasma total protein level
subclass of: renal cortex protein measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:45:26Z
def: Measurement of the total amount of all proteins found in a specific volume of afferent arteriolar plasma.
has exact synonym: Ca

efferent arteriolar plasma protein concentration
type: Class
subclass of: plasma total protein level
subclass of: renal cortex protein measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:49:32Z
def: Measurement of the total amount of all proteins found in a specific volume of efferent arteriolar plasma.
has exact synonym: Ce

afferent colloid osmotic pressure
type: Class
subclass of: arteriole measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T12:53:15Z
def: A form of osmotic pressure exerted by proteins, notably albumin, in the afferent arteriole's plasma that tends to pull water into the circulatory system. It is the opposing force to hydrostatic pressure. It has a major effect on the pressure across the glomerular filter.

efferent colloid osmotic pressure
type: Class
subclass of: arteriole measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T13:07:24Z
def: A form of osmotic pressure exerted by proteins, notably albumin, in the efferent arteriole's plasma that tends to pull water into the circulatory system. It is the opposing force to hydrostatic pressure. It has a major effect on the pressure across the glomerular filter

glomerular capillary ultrafiltration coefficient
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T13:11:50Z
def: A measure of a membrane's permeability to water; specifically, the volume of fluid filtered in unit time through a unit area of membrane per unit pressure difference, and it is defined as the glomerular filtration rate (GFR) for both kidneys per millimeter of mercury (mmHg) of filtration pressure.
has exact synonym: Kf

ratio of the area occupied by cysts to the total area of the kidney
type: Class
subclass of: calculated kidney non-tumorous lesion measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T14:28:13Z
def: A calculated measurement in which the area occupied by renal cysts is divided by the total the kidney, and the result presented as a ratio, fraction, quotient or percentage.

mean proximal tubular hydraulic pressure
type: Class
subclass of: renal cortex measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T15:20:35Z
def: Force exerted on the luminal surface of the proximal tubule from fluid flowing through the tubule.

efferent arteriolar hydraulic pressure
type: Class
subclass of: arteriole measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T15:22:41Z
def: Force exerted on the luminal vessel wall from fluid flowing through the efferent arteriole.
has exact synonym: efferent glomerular arteriolar hydraulic pressure

glomerular transcapillary hydraulic pressure gradient
type: Class
subclass of: capillary measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T15:27:01Z
def: The difference between the force exerted on the luminal glomerular capillary wall and the force exerted on the luminal proximal tubular membrane (Pgc - Pt = delta P).
has exact synonym: Pgc - Pt = delta P

calculated left ventricular end-diastolic blood pressure measurement
type: Class
subclass of: left ventricular end-diastolic blood pressure
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T15:58:18Z

heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio
type: Class
subclass of: heart left ventricular end-diastolic diameter
subclass of: calculated left ventricular end-diastolic blood pressure measurement
imported from: cmo.owl
created by: sjwang
creation date: 2018-12-27T16:00:35Z
def: A calculated measurement in which the pressure in the heart left ventricle at the end of diastole, the period when the heart is in a state of relaxation and expansion and the ventricles fill with blood, divided by the diameter across the left ventricle of the heart at the end of diastole and the result presented as a ratio, fraction, quotient or percentage.
has exact synonym: LVEDP/LVDd

rate-pressure product
type: Class
subclass of: calculated heart rate measurement
imported from: cmo.owl
created by: sjwang
creation date: 2019-01-02T13:36:28Z
def: Rate-pressure product is defined as the product of the heart rate (the number of contractions of the cardiac ventricles per unit of time) and mean arterial blood pressure (the average force the blood exerts on an artery wall).
has exact synonym: RPP

artery tunica media to artery total diameter ratio
type: Class
subclass of: calculated artery wall thickness measurement
imported from: cmo.owl
created by: sjwang
creation date: 2019-01-22T15:47:09Z
def: A calculated measurement of the average width of the tunica media (the middle coat of the arterial wall) divided by the artery total diameter (measured as the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the outer surface of the blood vessel wall).

artery lumen to artery total diameter ratio
type: Class
subclass of: calculated artery wall thickness measurement
imported from: cmo.owl
created by: sjwang
creation date: 2019-01-22T15:50:45Z
def: A calculated measurement of the average width of the artery lumen (measured as the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall) divided by the artery total diameter (measured as the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the outer surface of the blood vessel wall).

clinical drug role
type: Class
subclass of: role
definition: the role of a material entity to prevent, diagnose, treat, or study disease and/or its effects
definition editor: William Hogan
imported from: dron.owl
creator: William Hogan

drug product
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: is_bearer_of
    some values from: clinical drug role
  intersection of: Restriction
    on property: has_proper_part
    some values from: Class
      intersection of: scattered molecular aggregate
      intersection of: Restriction
        on property: is_bearer_of
        some values from: active ingredient
definition: a material entity (1) containing at least one scattered molecular aggregate as part that is the bearer of an active ingredient role and (2) that is itself the bearer of a clinical drug role
definition editor: William Hogan
imported from: dron.owl
creator: William Hogan

active ingredient
type: Class
subclass of: role of scattered molecular aggregate
subclass of: Restriction
  on property: realized in
  all values from: Class
    intersection of: process
    intersection of: Restriction
      on property: has part
      some values from: drug administration
    intersection of: Restriction
      on property: has part
      some values from: Class
        intersection of: process
        intersection of: Restriction
editor preferred label: active ingredient role
definition: a role of a scattered molecular aggregate that is part of a drug product that is realized by (1) administration of the drug to an organism followed by (2) some change in the structure or functioning of some part of the organism
definition editor: William R. Hogan
imported from: dron.owl

role of scattered molecular aggregate
type: Class
equivalent class: Class
  intersection of: role
  intersection of: Restriction
    on property: characteristic of
    some values from: scattered molecular aggregate
subclass of: role
editor preferred label: role of a scattered molecular aggregate
definition: a role borne by a scattered molecular aggregate and realized by its grains participating in one or more processes
definition editor: William R. Hogan
imported from: dron.owl

drug administration
type: Class
subclass of: treatment
subclass of: Class
  intersection of: treatment
  intersection of: Restriction
    on property: has_participant
    some values from: drug product
  intersection of: Restriction
    on property: has_participant
    some values from: organism
editor preferred label: administration of a drug product to an organism
definition: a treatment that has as participants an extended organism and a drug product and that results in part of the drug product being located in the extended organism
definition editor: William R. Hogan
imported from: dron.owl

geographic feature
type: Class
subclass of: astronomical body part
imported from: envo.owl
database_cross_reference: https://en.wikipedia.org/wiki/Geographic_feature
has exact synonym: macroscopic spatial feature
in subset: envoPolar
comment: May appear on a map.

anthropogenic geographic feature
type: Class
equivalent class: Class
  intersection of: astronomical body part
  intersection of: Restriction
    on property: formed as result of
    some values from: anthropisation
subclass of: geographic feature
subclass of: Restriction
  on property: formed as result of
  some values from: anthropisation
definition: An anthropogenic geographic feature is a geographic feature resulting from the influence of human beings on nature.
imported from: envo.owl
database_cross_reference: FTT:78
database_cross_reference: TGN:50001
has_related_synonym: man-made feature
has_related_synonym: manmade feature

administrative region
type: Class
subclass of: site
imported from: envo.owl
database_cross_reference: FTT:1242
database_cross_reference: FTT:1252
database_cross_reference: FTT:15
database_cross_reference: FTT:16
database_cross_reference: FTT:18
database_cross_reference: FTT:19
database_cross_reference: FTT:21
database_cross_reference: FTT:22
database_cross_reference: FTT:23
database_cross_reference: FTT:24
database_cross_reference: FTT:25
database_cross_reference: FTT:26
database_cross_reference: FTT:27
database_cross_reference: FTT:28
database_cross_reference: FTT:29
database_cross_reference: FTT:37
database_cross_reference: SWEETRealm:AdministrativeRegion
database_cross_reference: TGN:80001
database_cross_reference: TGN:81099
database_cross_reference: TGN:81123
database_cross_reference: https://en.wikipedia.org/wiki/Administrative_region
has exact synonym: administrative area
has_related_synonym: administrative division
has_related_synonym: administrative entity
has_related_synonym: boundary region
has_related_synonym: civil area
has_related_synonym: district
has_related_synonym: free trade zone
has_related_synonym: governed place
has_related_synonym: leased area (government)
has_related_synonym: leased zone (government)
has_related_synonym: neutral zone (political)
has_related_synonym: prefecture
has_related_synonym: protectorate
has_related_synonym: sheikdom
has_related_synonym: sultanate
has_related_synonym: trade zone

national geopolitical entity
type: Class
subclass of: political entity
definition: A political association with effective dominion over a geographic area.
imported from: envo.owl
imported from: gaz.owl
database_cross_reference: FTT:424
database_cross_reference: FTT:566
database_cross_reference: FTT:567
database_cross_reference: FTT:571
database_cross_reference: SWEETRealm:Country
database_cross_reference: SWEETRealm:State
database_cross_reference: TGN:80006
database_cross_reference: TGN:81010
database_cross_reference: TGN:81011
database_cross_reference: TGN:81102
database_cross_reference: https://en.wikipedia.org/wiki/Nation
has exact synonym: nation
has_narrow_synonym: independent nation
has_narrow_synonym: independent political entity
has_narrow_synonym: independent sovereign nation
has_obo_namespace: ENVO
has_related_synonym: country
has_related_synonym: political entity
has_related_synonym: state
id: ENVO:00000009

populated place
type: Class
subclass of: environmental zone
subclass of: Restriction
  on property: location_of
  some values from: Homo sapiens
subclass of: Restriction
  on property: location_of
  min qualified cardinality: 1
  on class: building
definition: Place or area with clustered or scattered buildings and a permanent human population.
imported from: envo.owl
has_broad_synonym: place
database_cross_reference: FTT:1097
database_cross_reference: FTT:33
database_cross_reference: Geonames:P.PPL
database_cross_reference: Geonames:P.PPLS
database_cross_reference: TGN:22201
database_cross_reference: TGN:83002
database_cross_reference: https://en.wikipedia.org/wiki/Populated_place
has exact synonym: inhabited place
has exact synonym: populated place
has exact synonym: populated places
has exact synonym: settlement
has_obo_namespace: ENVO
has_related_synonym: inhabited region
has_related_synonym: populated locality
id: ENVO:00000062

construction
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: output of
    some values from: construction process
equivalent class: Class
  intersection of: environmental feature
  intersection of: Restriction
    on property: output of
    some values from: construction process
subclass of: anthropogenic geographic feature
subclass of: Restriction
  on property: part of
  some values from: technosphere
subclass of: Restriction
  on property: output of
  some values from: construction process
definition: A feature that has been constructed by deliberate human effort.
editor note: "constructed" should probably be made something like a quality and this class obsoleted or filled only by inference
imported from: envo.owl
has exact synonym: constructed feature

building
type: Class
subclass of: construction
subclass of: Restriction
  on property: has part
  some values from: building part
definition: A permanent walled and roofed construction.
imported from: envo.owl
database_cross_reference: FTT:42
database_cross_reference: Geonames:S.BLDG
database_cross_reference: LTER:76
database_cross_reference: TGN:51011
database_cross_reference: https://en.wikipedia.org/wiki/Building
has exact synonym: BUILDING
has exact synonym: building

political entity
type: Class
subclass of: administrative region
definition: A geographical region whose affairs and population are administered by an authority.
imported from: envo.owl
database_cross_reference: FTT:1093
database_cross_reference: Geonames:A.PCL
database_cross_reference: TGN:80002
has_related_synonym: political entity

city
type: Class
subclass of: dense settlement
definition: Incorporated populated place.
imported from: envo.owl
has_broad_synonym: urban area
database_cross_reference: EcoLexicon:city
database_cross_reference: FTT:430
database_cross_reference: FTT:483
database_cross_reference: FTT:484
database_cross_reference: FTT:485
database_cross_reference: SWEETRealm:City
database_cross_reference: TGN:83020
database_cross_reference: TGN:83040
database_cross_reference: TGN:83043
database_cross_reference: https://en.wikipedia.org/wiki/City
has_obo_namespace: ENVO
id: ENVO:00000856

mesoscopic physical object
type: Class
subclass of: object
subclass of: environmental feature
definition: An environmental feature that is, or can be, contained and is predominantly composed of one or a few types of stuff.
definition: An object which is large enough to be visible to humans, but small enough that humans can handle the object (i.e. transport it, examine it, etc) in its entirety with little to no technological assistance.
alternative term: mesoscopic physical object
imported from: envo.owl
comment: This is a legacy class from ENVO's early versions. It will be depopulated and filled in by inference using a PATO quality. Not to be confused with "mesoscopic" as defined in physics, which deals with objects typically between 10e-6 and 10-8 meters in diameter.
label: physical object of mesoscopic geological size

environmental feature
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: determines
    some values from: environmental system
subclass of: material entity
subclass of: Restriction
  on property: determines
  some values from: environmental system
definition: A material entity which determines an environmental system.
imported from: envo.owl
has_obo_namespace: ENVO
id: ENVO:00002297
comment: A material entity determines an environmental system when its removal would cause the collapse of that system. For example, a seamount determines a seamount environment, acting as its 'hub'. This class is currently being aligned to the Basic Formal Ontology. Following this alignment, its definition and the definitions of its subclasses will be revised.

manufactured product
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: output of
    some values from: manufacturing process
subclass of: anthropogenic abiotic mesoscopic feature
subclass of: Restriction
  on property: output of
  some values from: manufacturing process
definition: A material entity that has been processed by humans or their technology in any way, including intermediate products as well as final products.
imported from: envo.owl
has exact synonym: manufactured good

anthropogenic abiotic mesoscopic feature
type: Class
subclass of: abiotic mesoscopic physical object
imported from: envo.owl
has_obo_namespace: ENVO
id: ENVO:00003075

environmental material
type: Class
subclass of: fiat object
subclass of: material entity
definition: A portion of environmental material is a fiat object part which forms the medium or part of the medium of an environmental system.
definition: A portion of environmental material is a fiat object which forms the medium or part of the medium of an environmental system.
imported from: envo.owl
has exact synonym: portion of environmental material
comment: Everything under this parent must be a mass noun. All subclasses are to be understood as being composed primarily of the named entity, rather than restricted to that entity. For example, "ENVO:water" is to be understood as "environmental material composed primarly of some CHEBI:water". This class is currently being aligned to the Basic Formal Ontology. Following this alignment, its definition and the definitions of its subclasses will be revised.

abiotic mesoscopic physical object
type: Class
subclass of: mesoscopic physical object
imported from: envo.owl
has_obo_namespace: ENVO
id: ENVO:01000010

environmental system
type: Class
subclass of: system
definition: A system which has the disposition to environ one or more material entities.
imported from: envo.owl
creation date: 2013-09-23T16:04:08Z
database_cross_reference: EcoLexicon:environment
has exact synonym: environment
comment: In ENVO's alignment with the Basic Formal Ontology, this class is being considered as a subclass of a proposed BFO class "system". The relation "environed_by" is also under development. Roughly, a system which includes a material entity (at least partially) within its site and causally influences that entity may be considered to environ it. Following the completion of this alignment, this class' definition and the definitions of its subclasses will be revised.

anthropogenic environment
type: Class
equivalent class: Class
  intersection of: environmental system
  intersection of: Restriction
    on property: determined by
    some values from: Restriction
      on property: output of
      some values from: anthropisation
subclass of: environmental system
subclass of: Restriction
  on property: determined by
  some values from: Restriction
    on property: output of
    some values from: anthropisation
definition: An anthropogenic environment is an environmental system which is the product of human activity.
imported from: envo.owl
comment: Unsatisfactory definition here. Must consider the threshold that makes an environmental system anthropogenic.

environmental zone
type: Class
subclass of: site
subclass of: Restriction
  on property: part of
  some values from: environmental system
definition: A site which has its extent determined by the presence or influence of one or more components of an environmental system or the processes occurring therein.
imported from: envo.owl
has_related_synonym: environmental area
in subset: envoPolar
comment: Formerly, this class was an experimental class and a subclass of "environmental feature". It is now aligned to BFO. The class was not obsoleted as the core semantics maintained their stability through its transition.

building part
type: Class
subclass of: construction
subclass of: Restriction
  on property: part of
  some values from: building
definition: A building part is a construction which is part of a building.
imported from: envo.owl
comment: Not recommended for annotation. This class is likely to be made into an inferred class as its subclasses are distributed among more meaningful superclasses (i.e. ceiling is_a surface layer). See for example, "building floor". The boundaries between building parts may be bona fide or fiat.

outer space
type: Class
subclass of: environmental feature
subclass of: environmental material
definition: Outer space is a hard vacuum containing a low density of particles, predominantly a plasma of hydrogen and helium as well as electromagnetic radiation, magnetic fields, neutrinos, dust and cosmic rays that exists between celestial bodies.
imported from: envo.owl
has_broad_synonym: space
in subset: envoAstro

dense settlement
type: Class
subclass of: populated place
definition: A settlement with a high density of buildings and inhabitants.
editor note: See also: http://www.ecotope.org/anthromes/v1/guide/urban/12_dense_settlements/default.aspx
imported from: envo.owl
comment: The thresholds for what makes a settlment "dense" can be determined as needed. If there is a specific threshold that should be added to ENVO, please make a new class request.

human dwelling
type: Class
subclass of: construction
subclass of: domestic building
definition: A self-contained constructed feature used by one or more households as a home, such as a house, apartment, mobile home, houseboat or other 'substantial' structure. A dwelling typically includes nearby outbuildings, sheds etc. within the curtilage of the property, excluding any 'open fields beyond'. It has significance in relation to search and seizure, conveyancing of real property, burglary, trespass, and land use planning.
editor note: See https://github.com/EnvironmentOntology/envo/issues/264 for discussion. This definition needs a lot of clean up and links to household and related classes must be made to form logical definitions for inference to work.
editor note: Subclasses will be added by inference.
imported from: envo.owl

village
type: Class
subclass of: populated place
definition: A village is a clustered human settlement or community, larger than a hamlet but smaller than a town, with a population ranging from a few hundred to a few thousand. Though often located in rural areas, the term urban village is also applied to certain urban neighbourhoods. Villages are normally permanent, with fixed dwellings; however, transient villages can occur. Further, the dwellings of a village are fairly close to one another, not scattered broadly over the landscape, as a dispersed settlement.
editor note: This class may be split. "urban village" doesn't sit well and prevents relations to village biomes.
imported from: envo.owl

astronomical body
type: Class
subclass of: astronomical object
definition: An object which is naturally occuring, bound together by gravitational or electromagnetic forces, and surrounded by space.
imported from: envo.owl
has_related_synonym: celestial body
in subset: envoAstro
comment: Astronomical bodies are usually cohesive, thus the use of the term 'object' sensu BFO 'object'.

astronomical object
type: Class
subclass of: object
subclass of: environmental feature
subclass of: Restriction
  on property: has quality
  some values from: geodiversity
subclass of: Restriction
  on property: surrounded by
  some values from: outer space
subclass of: Restriction
  on property: has part
  min qualified cardinality: 1
  on class: astronomical body
definition: An object which is composed of one or more gravitationally bound structures that are associated with a position in space.
imported from: envo.owl
has_related_synonym: celestial object
in subset: envoAstro
comment: If there is only one astronomical body involved, this class is equivalent to ENVO:01000799. This may be problematic with reasoning, but it seems to be true to the rather fuzzy definitions found thus far.

astronomical body part
type: Class
subclass of: fiat object
subclass of: environmental feature
subclass of: Restriction
  on property: part of
  some values from: astronomical body
definition: A material part of an astronomical body.
imported from: envo.owl
in subset: envoAstro
in subset: envoPolar

biosphere
type: Class
subclass of: astronomical body part
subclass of: ecosystem
subclass of: Restriction
  on property: has part
  some values from: collection of organisms
definition: A biosphere is a part of an astronomical body which includes, as parts, all the living entities within the gravitational sphere of influence of that body, as well as the non-living and dead entities with which they interact.
definition: A biosphere is an environmental system which includes, as parts, all the living entities within the gravitational sphere of influence of an astronomical body, and the non-living and dead entities which they interact with.
editor note: Whether this class should be grouped with classes such as "hydrosphere" and "cryosphere" requires some discussion.
imported from: envo.owl
in subset: envoAstro
in subset: envoPolar
comment: The gravitational sphere of influence referenced in this class' definition is the Hill sphere: a region in which an object dominates the attraction of satellites despite gravitational perturbations.

natural environment
type: Class
equivalent class: Class
  intersection of: environmental system
  intersection of: Class
    complement of: Restriction
      on property: contains process
      some values from: anthropisation
  intersection of: Class
    complement of: Restriction
      on property: formed as result of
      some values from: anthropisation
equivalent class: Class
  intersection of: environmental system
  intersection of: Class
    complement of: Restriction
      on property: formed as result of
      some values from: anthropisation
subclass of: environmental system
definition: An environmental system in which minimal to no anthropisation has occurred and non-human agents are the primary determinants of the system's dynamics and composition.
alternative term: non-anthropised environment
alternative term: non-anthropized environment
imported from: envo.owl
comment: In most contexts, 'natural' is defined by the lack of intervention or influence by humans and their activities. On Earth, most environments fall on a scale between completely natural and anthropised.

anthropisation
type: Class
equivalent class: Class
  intersection of: anthropogenic ecosystem conversion process
  intersection of: Restriction
    on property: has input
    some values from: natural environment
  intersection of: Restriction
    on property: has output
    some values from: anthropogenic environment
equivalent class: Class
  intersection of: anthropogenic environmental process
  intersection of: Restriction
    on property: has input
    some values from: natural environment
  intersection of: Restriction
    on property: has output
    some values from: anthropogenic environment
subclass of: anthropogenic ecosystem conversion process
subclass of: anthropogenic environmental process
subclass of: Restriction
  on property: has input
  some values from: natural environment
subclass of: Restriction
  on property: has output
  some values from: anthropogenic environment
definition: A process during which a natural environmental system is altered by human action.
imported from: envo.owl
has exact synonym: anthropization
comment: An area may be classified as anthropized even though it looks natural, such as grasslands that have been deforested by humans. It can be difficult to determine how much a site has been anthropized in the case of urbanization because one must be able to estimate the state of the landscape before significant human action.

technosphere
type: Class
subclass of: astronomical body part
subclass of: Restriction
  on property: has part
  some values from: construction
subclass of: Restriction
  on property: has part
  some values from: manufactured product
subclass of: Restriction
  on property: overlaps
  some values from: biosphere
definition: A part of an astronomical body which includes, as parts, all the entities which have been constructed or manufactured by humans or their technology and which are within the gravitational sphere of influence of that body.
definition: An environmental system which includes, as parts, all the entities which have been constructed or manufactured by humans or their technology within the gravitational sphere of influence of an astronomical body.
imported from: envo.owl
in subset: envoAstro
comment: The gravitational sphere of influence referenced in this class' definition is the Hill sphere: a region in which an object dominates the attraction of satellites despite gravitational perturbations.

manufacturing process
type: Class
equivalent class: Class
  intersection of: anthropisation
  intersection of: Restriction
    on property: has output
    some values from: manufactured product
equivalent class: Class
  intersection of: planned process
  intersection of: Restriction
    on property: has output
    some values from: manufactured product
subclass of: anthropisation
subclass of: planned process
subclass of: Restriction
  on property: has output
  some values from: manufactured product
definition: A planned process during which raw or recycled materials are transformed into products for use or sale using labour and machines, tools, chemical and biological processing, or formulation.
imported from: envo.owl
comment: The term may refer to a range of human activity, from handicraft to high tech, but is most commonly applied to industrial production, in which raw materials are transformed into finished goods on a large scale.

construction process
type: Class
equivalent class: Class
  intersection of: anthropisation
  intersection of: Restriction
    on property: has output
    some values from: construction
equivalent class: Class
  intersection of: planned process
  intersection of: Restriction
    on property: has output
    some values from: construction
subclass of: anthropisation
subclass of: planned process
subclass of: Restriction
  on property: has part
  some values from: material transport process
subclass of: Restriction
  on property: has part
  some values from: material transformation process
subclass of: Restriction
  on property: has output
  some values from: construction
definition: An process during which natural or manufactured materials and products are processed and arranged by humans or their technology into structures.
editor note: The nature of "structures" must be further specified.
imported from: envo.owl

ecosystem
type: Class
subclass of: environmental system
definition: An environmental system which includes both living and non-living components.
imported from: envo.owl
has_alternative_id: LTER:173
comment: This class will be primarily filled by inference, any environmental system which necessarily includes living parts should be autoclassified here.

geodiversity
type: Class
subclass of: physical object quality
definition: A quality which inheres in a astronomical body or astronomical body part by virtue of the variation in its material composition, participation in geological processes, and the variation in is land- and hydroforms.
imported from: envo.owl
comment: Materials which are usually assessed when appraising geodiversity include minerals, rocks, sediments, fossils, soils and water. Landforms factored into geodiversity metrics typically include folds, faults, and other expressions of morphology or relations between units of earth material. Natural processes that are included in measures of geodiversity are those which either maintain or change materials or geoforms, including tectonics, sediment transport, and pedogenesis. Geodiversity does not usually factor in anthropogenic entities.

active ecosystem management process
type: Class
subclass of: anthropogenic modulatory intervention process
subclass of: anthropogenic environmental process
subclass of: Restriction
  on property: has_participant
  some values from: ecosystem
definition: A process during which an ecosystem, its parts, or the processes it participates in are modified by human intervention to accomplish an objective.
imported from: envo.owl
has exact synonym: ecosystem management
has_related_synonym: Umweltmaßnahme @de
has_related_synonym: environmental management

anthropogenic ecosystem conversion process
type: Class
subclass of: anthropogenic environmental process
definition: A process during which an ecosystem - natural or anthropised - is changed by the actions of humans.
imported from: envo.owl
created by: http://orcid.org/0000-0002-4366-3088

planned environmental usage process
type: Class
subclass of: anthropogenic environmental process
subclass of: planned process
subclass of: Restriction
  on property: has part
  some values from: active ecosystem management process
subclass of: Restriction
  on property: has_participant
  some values from: Class
    union of: anthropogenic environment
    union of: natural environment
definition: A planned process during which humans access and obtain resources, benefits, or services from a natural or anthropised ecosystem.
imported from: envo.owl
created by: http://orcid.org/0000-0002-4366-3088

usage of an environment for residential activity
type: Class
subclass of: planned environmental usage process
subclass of: Restriction
  on property: has_participant
  some values from: human dwelling
subclass of: Restriction
  on property: has_participant
  some values from: Class
    intersection of: ecological community
    intersection of: Restriction
      on property: composed primarily of
      some values from: Homo sapiens
definition: A planned environmental usage process during which an environment supports the settlement and dwelling of a community of humans.
imported from: envo.owl
created by: http://orcid.org/0000-0002-4366-3088
has_broad_synonym: residential
comment: This class does not include environments which are primarily used for commerce or industry.

domestic building
type: Class
equivalent class: Class
  intersection of: building
  intersection of: Restriction
    on property: participates in
    some values from: usage of an environment for residential activity
subclass of: building
subclass of: Restriction
  on property: participates in
  some values from: usage of an environment for residential activity
definition: A building which is primarily used for the long-term habitation of humans.
imported from: envo.owl
created by: http://orcid.org/0000-0002-4366-3088
creation date: 2018-10-04T14:04:49Z

environmental system process
type: Class
equivalent class: Class
  intersection of: process
  intersection of: Restriction
    on property: has_participant
    some values from: Class
      union of: environmental feature
      union of: environmental material
      union of: environmental system
subclass of: process
subclass of: Restriction
  on property: has_participant
  some values from: Class
    union of: environmental feature
    union of: environmental material
    union of: environmental system
definition: A process in which includes the components of an environmental system as participants.
imported from: envo.owl
comment: This is a convenience class for organisation and should not be used for annotation.

anthropogenic modulatory intervention process
type: Class
equivalent class: Class
  intersection of: planned process
  intersection of: Restriction
    on property: regulates (processual)
    some values from: environmental system process
  intersection of: Restriction
    on property: has active participant
    some values from: Homo sapiens
subclass of: planned process
subclass of: Restriction
  on property: regulates (processual)
  some values from: environmental system process
subclass of: Restriction
  on property: has active participant
  some values from: Homo sapiens
definition: A process during which humans apply technology to alter the magnitude, duration, rate, or impact of an environmental process.
imported from: envo.owl
comment: Relabel the obo foundry unique label to be generic process

anthropogenic environmental process
type: Class
equivalent class: Class
  intersection of: environmental system process
  intersection of: Restriction
    on property: has active participant
    some values from: Homo sapiens
subclass of: environmental system process
subclass of: Restriction
  on property: has active participant
  some values from: Homo sapiens
definition: An environmental process which is driven by the action of humans.
imported from: envo.owl

material transport process
type: Class
subclass of: environmental system process
subclass of: Restriction
  on property: has output
  some values from: Class
    intersection of: material entity
    intersection of: Restriction
      on property: has quality
      some values from: displaced
definition: A process during which material is displaced from its original location and transported either to a new location or back to the original location.
definition editor: http://orcid.org/0000-0002-3410-4655
definition editor: http://orcid.org/0000-0002-4366-3088
imported from: envo.owl
in subset: envoPolar
comment: Experimental class for structural purposes not recommended for annotation.

material transformation process
type: Class
subclass of: environmental system process
subclass of: Restriction
  on property: has input
  some values from: environmental material
subclass of: Restriction
  on property: has output
  some values from: environmental material
definition: A process during which a portion of some environmental material is converted into a different material or a collection of materials.
editor note: A different material transformation process class (or similarly named class) pertaining to the conversion of a specific chemical into another belongs in CHEBI and or REX ontologies.
definition editor: http://orcid.org/0000-0002-3410-4655
definition editor: http://orcid.org/0000-0002-4366-3088
imported from: envo.owl
in subset: envoPolar
comment: Experimental class for structural purposes not recommended for annotation. A material transformation process only refers to ENVO:environmental material classes (e.g. bulk and typically impure substances), rather than transformations converting a specific chemical into another.

continent
type: Class
subclass of: geographic location
type: NamedIndividual
id: GAZ:00000013
definition: One of the large, unbroken masses of land into which the Earth's surface is divided.
imported from: gaz.owl
database_cross_reference: FTT:540
database_cross_reference: TGN:21402
has_obo_namespace: GAZ
database_cross_reference: GeoNames:CONT
has exact synonym: continental region
has_alternative_id: GAZ:00190836
has exact synonym: CONTIN
has exact synonym: continent {alternative name}
has exact synonym: Continent {alternative name}
database_cross_reference: TGN:29000

geographic location
type: Class
subclass of: site
type: NamedIndividual
imported from: iao.owl
has_alternative_id: GAZ:00000467
id: GAZ:00000448
definition: A reference to a place on the Earth, by its name or by its geographical location.
has_obo_namespace: GAZ
has exact synonym: geographic region {alternative name}
imported from: gaz.owl
editor preferred label: geographic location

Eurasia
type: Class
subclass of: continent
type: NamedIndividual
id: GAZ:00000460
has_obo_namespace: GAZ
imported from: gaz.owl
definition: The convention used in gaz.obo is that the Europe-Asia boundary follows the watershed of the Ural Mountains from near Kara, Russia on the Kara Sea to the source of the Ural River, then follows that river to the Caspian Sea. The border then follows the watershed of the Caucasus Mountains from the Caspian Sea to the Black Sea.

United States of America
type: Class
subclass of: geographic location
type: NamedIndividual
has exact synonym: USA
id: GAZ:00002459
has_obo_namespace: GAZ
database_cross_reference: ISO3166-1:US
database_cross_reference: ISO3166-1:840
definition: A federal constitutional republic comprising fifty states and a federal district. The country is situated mostly in central North America, where its forty-eight contiguous states and Washington, DC, the capital district, lie between the Pacific and Atlantic Oceans, bordered by Canada to the north and Mexico to the south. The State of Alaska is in the northwest of the continent, with Canada to its east and Russia to the west across the Bering Strait, and the State of Hawaii is in the mid-Pacific. The United States also possesses several territories, or insular areas, that are scattered around the Caribbean and Pacific. The states are divided into smaller administrative regions, called counties in most states, exceptions being Alaska (parts of the state are organized into subdivisions called boroughs; the rest of the state's territory that is not included in any borough is divided into "census areas"), and Louisiana (which is divided into county-equivalents that are called parishes). There are also independent cities which are within particular states but not part of any particular county or consolidated city-counties. Another type of organization is where the city and county are unified and function as an independent city. There are thirty-nine independent cities in Virginia and other independent cities or city-counties are San Francisco, California, Baltimore, Maryland, St. Louis, Missouri, Denver, Colorado and Carson City, Nevada. Counties can include a number of cities, towns, villages, or hamlets, or sometimes just a part of a city. Counties have varying degrees of political and legal significance, but they are always administrative divisions of the state. Counties in many states are further subdivided into townships, which, by definition, are administrative divisions of a county. In some states, such as Michigan, a township can file a charter with the state government, making itself into a "charter township", which is a type of mixed municipal and township statu…
has exact synonym: U.S.A
imported from: gaz.owl
database_cross_reference: ISO3166-2:US
database_cross_reference: ISO3166-1:USA

immunoglobulin complex
type: Class
subclass of: protein-containing complex
editor preferred label: immunoglobulin complex
definition: A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
imported from: go.owl
imported from: Ontology for Biomedical Investigations

B cell receptor complex
type: Class
subclass of: adaptive immune receptor
editor preferred label: B cell receptor complex
definition: An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
imported from: go.owl
imported from: Ontology for Biomedical Investigations

protein-containing complex
type: Class
subclass of: material entity
subclass of: Restriction
  on property: has part
  some values from: protein
editor preferred label: protein-containing complex
example of usage: A ribosome is a protein complex.
definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
alternative term: protein complex
imported from: go.owl
imported from: Ontology for Biomedical Investigations

T cell receptor complex
type: Class
subclass of: adaptive immune receptor
editor preferred label: T cell receptor complex
definition: A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
imported from: go.owl
imported from: Ontology for Biomedical Investigations

immunoglobulin complex, circulating
type: Class
subclass of: immunoglobulin complex
subclass of: adaptive immune receptor
editor preferred label: immunoglobulin complex, circulating
definition: An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
alternative term: antibody
imported from: go.owl
imported from: Ontology for Biomedical Investigations
IEDB alternative term: antibody

Phenotypic abnormality
type: Class
subclass of: quality
definition: A phenotypic abnormality.
imported from: hp.owl

Osteoporosis
type: Class
subclass of: Phenotypic abnormality
definition: Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO, osteoporosis is characterized by a value of BMD 2.5 standard deviations or more below the young adult mean.
imported from: hp.owl

Eczema
type: Class
subclass of: Phenotypic abnormality
definition: Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding.
imported from: hp.owl

Abnormality of the cardiovascular system
type: Class
subclass of: Phenotypic abnormality
definition: Any abnormality of the cardiovascular system.
imported from: hp.owl

Abnormality of metabolism/homeostasis
type: Class
subclass of: Phenotypic abnormality
imported from: hp.owl

Fever
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: Elevated body temperature due to failed thermoregulation.
imported from: hp.owl

Gastroesophageal reflux
type: Class
subclass of: Morphological abnormality of the gastrointestinal tract
subclass of: Functional abnormality of the gastrointestinal tract
definition: A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter.
imported from: hp.owl

Anorexia
type: Class
subclass of: Abnormality of digestive system physiology
definition: A lack or loss of appetite for food (as a medical condition).
imported from: hp.owl

Abnormality of the respiratory system
type: Class
subclass of: Phenotypic abnormality
definition: An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.
imported from: hp.owl

Dyspnea
type: Class
subclass of: Functional respiratory abnormality
definition: Difficult or labored breathing.
imported from: hp.owl

Headache
type: Class
subclass of: Abnormality of nervous system physiology
definition: Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
imported from: hp.owl

Drowsiness
type: Class
subclass of: Abnormality of nervous system physiology
definition: Excessive daytime sleepiness.
imported from: hp.owl

Functional respiratory abnormality
type: Class
subclass of: Abnormality of the respiratory system
imported from: hp.owl

Atrial fibrillation
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute.
imported from: hp.owl

Stridor
type: Class
subclass of: Abnormal breath sound
definition: Stridor is a high pitched sound resulting from turbulent air flow in the upper airway.
imported from: hp.owl

Edema of the lower limbs
type: Class
subclass of: Phenotypic abnormality
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormal accumulation of fluid beneath the skin of the legs.
imported from: hp.owl

Abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the digestive system
definition: An abnormality of the gastrointestinal tract.
imported from: hp.owl

Abnormality of cardiovascular system physiology
type: Class
subclass of: Abnormality of the cardiovascular system
definition: Abnormal functionality of the cardiovascular system.
imported from: hp.owl

Respiratory tract infection
type: Class
subclass of: Abnormality of the respiratory system
definition: An infection of the upper or lower respiratory tract.
imported from: hp.owl

Chemosis
type: Class
subclass of: Phenotypic abnormality
definition: Edema (swelling) of the bulbar conjunctiva.
imported from: hp.owl

Abnormality of nervous system physiology
type: Class
subclass of: Phenotypic abnormality
definition: A functional anomaly of the nervous system.
imported from: hp.owl

Morphological abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
subclass of: Abnormality of the digestive system
definition: Abnormal structure of the gastrointestinal tract.
imported from: hp.owl

Functional abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
subclass of: Abnormality of digestive system physiology
definition: Abnormal functionality of the gastrointestinal tract.
imported from: hp.owl

Cough
type: Class
subclass of: Functional respiratory abnormality
definition: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
imported from: hp.owl

Abnormality of the digestive system
type: Class
subclass of: Phenotypic abnormality
imported from: hp.owl

Abnormality of digestive system physiology
type: Class
subclass of: Abnormality of the digestive system
definition: A functional anomaly of the digestive system.
imported from: hp.owl

Abnormal vascular physiology
type: Class
subclass of: Abnormality of the cardiovascular system
subclass of: Abnormality of cardiovascular system physiology
definition: Abnormality of vascular function.
imported from: hp.owl

Wheezing
type: Class
subclass of: Abnormal breath sound
definition: A high-pitched whistling sound associated with labored breathing.
imported from: hp.owl

Abnormal breath sound
type: Class
subclass of: Functional respiratory abnormality
definition: An anomalous (adventitious) sound produced by the breathing process.
imported from: hp.owl

Rales
type: Class
subclass of: Abnormal breath sound
definition: Abnormal breath sounds characterized by discontinuous clicking or rattling.
imported from: hp.owl

Rhonchi
type: Class
subclass of: Abnormal breath sound
definition: Abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds.
imported from: hp.owl

Elevated jugular venous pressure
type: Class
subclass of: Abnormal vascular physiology
definition: Increased jugular venous pressure.
imported from: hp.owl

measurement unit label
type: Class
subclass of: datum label
editor preferred label: measurement unit label
example of usage: Examples of measurement unit labels are liters, inches, weight per volume.
has curation status: pending final vetting
definition: A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure.
editor note: 2009-03-16: provenance: a term measurement unit was proposed for OBI (OBI_0000176) , edited by Chris Stoeckert and Cristian Cocos, and subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definition of this, different, term.
editor note: 2009-03-16: review of this term done during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Melanie Courtot
imported from: iao.owl

objective specification
type: Class
subclass of: directive information entity
editor preferred label: objective specification
example of usage: In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction.
has curation status: ready for release
definition: A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved.
editor note: 2009-03-16: original definition when imported from OBI read: "objective is an non realizable information entity which can serve as that proper part of a plan towards which the realization of the plan is directed."
editor note: 2014-03-31: In the example of usage ("In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction") there is a protocol which is the ChIP assay protocol. In addition to being concretized on paper, the protocol can be concretized as a realizable entity, such as a plan that inheres in a person. The objective specification is the part that says that some protein and DNA interactions are identified. This is a specification of a process endpoint: the boundary in the process before which they are not identified and after which they are. During the realization of the plan, the goal is to get to the point of having the interactions, and participants in the realization of the plan try to do that.
editor note: Answers the question, why did you do this experiment?
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Barry Smith
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Jennifer Fostel
alternative term: goal specification
definition source: OBI Plan and Planned Process/Roles Branch
definition source: OBI_0000217
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

action specification
type: Class
subclass of: directive information entity
example of usage: Pour the contents of flask 1 into flask 2
has curation status: ready for release
definition: A directive information entity that describes an action the bearer will take.
definition editor: Alan Ruttenberg
definition source: OBI Plan and Planned Process branch
imported from: Ontology for Biomedical Investigations

datum label
type: Class
subclass of: information content entity
editor preferred label: datum label
has curation status: metadata incomplete
definition: A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label
editor note: http://www.golovchenko.org/cgi-bin/wnsearch#4n
definition editor: GROUP: IAO
curator note: 9/22/11 BP: changed the rdfs:label for this class from 'label' to 'datum label' to convey that this class is not intended to cover all kinds of labels (stickers, radiolabels, etc.), and not even all kind of textual labels, but rather the kind of labels occuring in a datum.
imported from: iao.owl

model number
type: Class
subclass of: symbol
editor preferred label: model number
has curation status: pending final vetting
definition: A model number is an information content entity specifically borne by catalogs, design specifications, advertising materials, inventory systems and similar that is about manufactured objects of the same class. The model number is an alternative term for the class. The manufactered objects may or may not also bear the model number. Model numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots.
editor note: manufactered items may have more than one model number, sometimes by rebranding, or because companies are sold and the products issued new model numbers
definition editor: Person: Alan Ruttenberg
imported from: iao.owl

data item
type: Class
subclass of: information content entity
editor preferred label: data item
example of usage: Data items include counts of things, analyte concentrations, and statistical summaries.
has curation status: pending final vetting
definition: An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.
definition: a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.
editor note: 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers.
editor note: 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum.
editor note: 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym.
editor note: 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/
editor note: JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Chris Stoeckert
definition editor: PERSON: Jonathan Rees
alternative term: data
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl

symbol
type: Class
subclass of: information content entity
editor preferred label: symbol
example of usage: a serial number such as "12324X"
example of usage: a stop sign
example of usage: a written proper name such as "OBI"
has curation status: pending final vetting
definition: An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity.
editor note: 20091104, MC: this needs work and will most probably change
editor note: 2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://code.google.com/p/information-artifact-ontology/issues/detail?id=154).
editor note: 2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154).
definition editor: PERSON: James A. Overton
definition editor: PERSON: Jonathan Rees
definition source: based on Oxford English Dictionary
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

numeral
type: Class
subclass of: symbol
editor preferred label: numeral
has curation status: metadata incomplete
definition: A symbol that denotes a number.
definition editor: PERSON: Jonathan Rees
imported from: iao.owl

information content entity
type: Class
subclass of: generically dependent continuant
subclass of: Restriction
  on property: is about
  some values from: entity
editor preferred label: information content entity
example of usage: Examples of information content entites include journal articles, data, graphical layouts, and graphs.
has curation status: ready for release
definition: A generically dependent continuant that is about some thing.
editor note: 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ).
editor note: information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity.
definition editor: PERSON: Chris Stoeckert
definition source: OBI_0000142
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: ico.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl

integer numeral
type: Class
subclass of: numeral
editor preferred label: integer numeral
has curation status: metadata incomplete
definition: a numeral that denotes an integer
definition editor: PERSON: Jonathan Rees
imported from: iao.owl

scalar measurement datum
type: Class
subclass of: measurement datum
subclass of: Restriction
  on property: has measurement unit label
  min cardinality: 1
subclass of: Restriction
  on property: has measurement value
  min cardinality: 1
example of usage: 10 feet. 3 ml.
has curation status: metadata complete
definition: a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label.
editor note: 2009-03-16: we decided to keep datum singular in scalar measurement datum, as in this case we explicitly refer to the singular form
editor note: Would write this as: has_part some 'measurement unit label' and has_part some numeral and has_part exactly 2, except for the fact that this won't let us take advantage of OWL reasoning over the numbers. Instead use has measurment value property to represent the same. Use has measurement unit label (subproperty of has_part) so we can easily say that there is only one of them.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Melanie Courtot
imported from: iao.owl

directive information entity
type: Class
subclass of: information content entity
subclass of: Restriction
  on property: is about
  some values from: realizable entity
has curation status: ready for release
definition: An information content entity whose concretizations indicate to their bearer how to realize them in a process.
editor note: 2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was "is the specification of a process that can be concretized and realized by an actor" with alternative term "instruction".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term.
editor note: 2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it.
editor note: 8/6/2009 Alan Ruttenberg: Changed label from "information entity about a realizable" after discussions at ICBO
editor note: Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

dot plot
type: Class
subclass of: graph
editor preferred label: dot plot
example of usage: Dot plot of SSC-H and FSC-H.
has curation status: example to be eventually removed
definition: A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions.
definition editor: person:Allyson Lister
definition editor: person:Chris Stoeckert
definition source: OBI_0000123
definition source: group:OBI
imported from: iao.owl

graph
type: Class
subclass of: diagram
editor preferred label: graph
has curation status: pending final vetting
definition: A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way.
definition editor: PERSON: Lawrence Hunter
definition editor: person:Alan Ruttenberg
definition editor: person:Allyson Lister
definition source: OBI_0000240
definition source: group:OBI
imported from: iao.owl

contour plot
type: Class
subclass of: graph
editor preferred label: contour plot
example of usage: Contour plot of SSC-H, FSC-H, and FL1-H.
has curation status: example to be eventually removed
editor note: generically_dependent_continuants
definition editor: person:Allyson Lister
definition editor: person:Chris Stoeckert
definition source: OBI_0000246
definition source: group:Flow Cytometry community
imported from: iao.owl

curation status specification
type: Class
equivalent class: Class
  one of: example to be eventually removed
  one of: metadata complete
  one of: organizational term
  one of: ready for release
  one of: metadata incomplete
  one of: uncurated
  one of: pending final vetting
  one of: to be replaced with external ontology term
  one of: requires discussion
subclass of: data about an ontology part
editor preferred label: curation status specification
has curation status: pending final vetting
definition: The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value.
editor note: Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)
definition editor: PERSON:Bill Bug
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition source: OBI_0000266
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl

density plot
type: Class
subclass of: graph
editor preferred label: density plot
example of usage: Density plot of SSC-H and FSC-H.
has curation status: example to be eventually removed
definition: A density plot is a report graph which is a graphical representation of data where the tint of a particular pixel corresponds to some kind of function corresponding the the amount of data points relativelly with their distance from the the pixel.
definition editor: person:Allyson Lister
definition editor: person:Chris Stoeckert
definition source: OBI_0000179
definition source: group:Flow Cytometry community
imported from: iao.owl

data set
type: Class
subclass of: data item
editor preferred label: data set
example of usage: Intensity values in a CEL file or from multiple CEL files comprise a data set (as opposed to the CEL files themselves).
has curation status: pending final vetting
definition: A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets.
editor note: 2009/10/23 Alan Ruttenberg. The intention is that this term represent collections of like data. So this isn't for, e.g. the whole contents of a cel file, which includes parameters, metadata etc. This is more like java arrays of a certain rather specific type
editor note: 2014-05-05: Data sets are aggregates and thus must include two or more data items. We have chosen not to add logical axioms to make this restriction.
definition editor: person:Allyson Lister
definition editor: person:Chris Stoeckert
definition source: OBI_0000042
definition source: group:OBI
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

image
type: Class
subclass of: figure
editor preferred label: image
has curation status: ready for release
definition: An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface.
definition editor: person:Alan Ruttenberg
definition editor: person:Allyson
definition editor: person:Chris Stoeckert
definition source: OBI_0000030
definition source: group:OBI
imported from: iao.owl

data about an ontology part
type: Class
subclass of: data item
editor preferred label: data about an ontology part
definition: Data about an ontology part is a data item about a part of an ontology, for example a term
definition: data about an ontology part is a data item about a part of an ontology, for example a term
definition editor: Person:Alan Ruttenberg
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl

plan specification
type: Class
subclass of: directive information entity
subclass of: Restriction
  on property: has part
  some values from: objective specification
subclass of: Restriction
  on property: has part
  some values from: action specification
editor preferred label: plan specification
example of usage: PMID: 18323827.Nat Med. 2008 Mar;14(3):226.New plan proposed to help resolve conflicting medical advice.
has curation status: ready for release
definition: A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified.
editor note: 2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was " a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan". It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term.
editor note: 2014-03-31: A plan specification can have other parts, such as conditional specifications.
editor note: Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved
definition editor: Alan Ruttenberg
definition source: OBI Plan and Planned Process branch
definition source: OBI_0000344
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
comment: 2/3/2009 Comment from OBI review. Action specification not well enough specified. Conditional specification not well enough specified. Question whether all plan specifications have objective specifications. Request that IAO either clarify these or change definitions not to use them

measurement datum
type: Class
subclass of: data item
subclass of: Restriction
  on property: has value specification
  some values from: value specification
editor preferred label: measurement datum
example of usage: Examples of measurement data are the recoding of the weight of a mouse as {40,mass,"grams"}, the recording of an observation of the behavior of the mouse {,process,"agitated"}, the recording of the expression level of a gene as measured through the process of microarray experiment {3.4,luminosity,}.
has curation status: pending final vetting
definition: A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device.
editor note: 2/2/2009 is_specified_output of some assay?
definition editor: person:Chris Stoeckert
definition source: OBI_0000305
definition source: group:OBI
imported from: iao.owl
imported from: Ontology for Biomedical Investigations

version number
type: Class
subclass of: symbol
editor preferred label: version number
has curation status: metadata incomplete
definition: A version number is an information content entity which is a sequence of characters borne by part of each of a class of manufactured products or its packaging and indicates its order within a set of other products having the same name.
editor note: Note: we feel that at the moment we are happy with a general version number, and that we will subclass as needed in the future. For example, see 7. genome sequence version
definition editor: GROUP: IAO
imported from: iao.owl

serial number
type: Class
subclass of: symbol
editor preferred label: serial number
has curation status: metadata incomplete
definition: A serial number is an information content entity which is a unique sequence of characters borne by part of manufactured product or its packaging that is assigned to each individual in some class of products, and so can serve as a way to identify an individual product within the class. Serial numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots.
editor note: Note: during the call there was some confusion between serial number and model number. We agreed that it would be very helpful for all those terms to have example of usages - please add if you have any :-)
definition editor: GROUP: IAO
imported from: iao.owl

lot number
type: Class
subclass of: symbol
editor preferred label: lot number
has curation status: metadata incomplete
definition: A lot number is an information content entity which is an identical sequence of character borne by part of manufactured product or its packaging for each instances of a product class in a discrete batch of an item. Lot numbers are usually assigned to each separate production run of an item. Manufacturing as a lot might be due to a variety of reasons, for example, a single process during which many individuals are made from the same portion of source material. Lot numbers can be encoded in a pattern of other information objects, such as bar codes, numerals, or patterns of dots.
definition editor: GROUP: IAO
alternative term: batch number
imported from: iao.owl

histogram
type: Class
subclass of: graph
editor preferred label: histogram
has curation status: ready for release
definition: A histogram is a report graph which is a statistical description of a distribution in terms of occurrence frequencies of different event classes.
definition editor: PERSON:Chris Stoeckert
definition editor: PERSON:James Malone
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBI
imported from: iao.owl

heatmap
type: Class
subclass of: graph
editor preferred label: heatmap
has curation status: ready for release
definition: A heatmap is a report graph which is a graphical representation of data where the values taken by a variable(s) are shown as colors in a two-dimensional map.
definition editor: PERSON:Chris Stoeckert
definition editor: PERSON:James Malone
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBI
imported from: iao.owl

Venn diagram
type: Class
subclass of: graph
editor preferred label: Venn diagram
has curation status: ready for release
definition: A Venn diagram is a report graph showing all hypothetically possible logical relations between a finite collection of sets.
definition editor: PERSON:Chris Stoeckert
definition editor: PERSON:James Malone
definition editor: PERSON:Melanie Courtot
definition source: WEB: http://en.wikipedia.org/wiki/Venn_diagram
imported from: iao.owl

dendrogram
type: Class
subclass of: graph
editor preferred label: dendrogram
example of usage: Dendrograms are often used in computational biology to illustrate the clustering of genes.
has curation status: ready for release
definition: A dendrogram is a report graph which is a tree diagram frequently used to illustrate the arrangement of the clusters produced by a clustering algorithm.
definition editor: PERSON:Chris Stoeckert
definition editor: PERSON:James Malone
definition editor: PERSON:Melanie Courtot
definition source: WEB: http://en.wikipedia.org/wiki/Dendrogram
imported from: iao.owl

scatter plot
type: Class
subclass of: graph
editor preferred label: scatter plot
example of usage: Comparison of gene expression values in two samples can be displayed in a scatter plot
has curation status: ready for release
definition: A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis.
definition editor: PERSON:Chris Stoeckert
definition editor: PERSON:James Malone
definition editor: PERSON:Melanie Courtot
alternative term: scattergraph
definition source: WEB: http://en.wikipedia.org/wiki/Scatterplot
imported from: iao.owl

photograph
type: Class
subclass of: image
has curation status: ready for release
definition: A photograph is created by projecting an image onto a photosensitive surface such as a chemically treated plate or film, CCD receptor, etc.
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Joanne Luciano
definition editor: PERSON:Melanie Courtot
definition source: WEB: http://en.wiktionary.org/wiki/photograph
imported from: iao.owl

textual entity
type: Class
subclass of: information content entity
editor preferred label: textual entity
example of usage: Words, sentences, paragraphs, and the written (non-figure) parts of publications are all textual entities
has curation status: metadata incomplete
definition: A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc.
editor note: AR, (IAO call 2009-09-01): a document as a whole is not typically a textual entity, because it has pictures in it - rather there are parts of it that are textual entities. Examples: The title, paragraph 2 sentence 7, etc.
editor note: MC, 2009-09-14 (following IAO call 2009-09-01): textual entities live at the FRBR (http://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records) manifestation level. Everything is significant: line break, pdf and html versions of same document are different textual entities.
definition editor: PERSON: Lawrence Hunter
alternative term: text
imported from: iao.owl
imported from: Ontology for Biomedical Investigations

citation
type: Class
subclass of: textual entity
subclass of: Restriction
  on property: is about
  some values from: document
editor preferred label: citation
example of usage: Verspoor, K., Cohen, KB., Hunter, L. Textual characteristics of traditional and Open Access scientific journals are similar, BMC Bioinformatics 2009, 10:183.
has curation status: pending final vetting
definition: a textual entity intended to identify a particular publication
definition editor: PERSON: Lawrence Hunter
imported from: iao.owl

document title
type: Class
subclass of: textual entity
editor preferred label: document title
example of usage: Textual characteristics of traditional and Open Access scientific journals are similar
has curation status: pending final vetting
definition: A textual entity that names a document
definition editor: PERSON: Lawrence Hunter
imported from: iao.owl

table
type: Class
subclass of: textual entity
editor preferred label: table
example of usage: | T F --+----- T | T F F | F F
has curation status: pending final vetting
definition: A textual entity that contains a two-dimensional arrangement of texts repeated at regular intervals across a spatial range, such that the spatial relationships among the constituent texts expresses propositions
definition editor: PERSON: Lawrence Hunter
imported from: iao.owl

figure
type: Class
subclass of: information content entity
editor preferred label: figure
example of usage: Any picture, diagram or table
has curation status: metadata complete
definition: An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something.
definition editor: PERSON: Lawrence Hunter
imported from: iao.owl

diagram
type: Class
subclass of: figure
editor preferred label: diagram
example of usage: A molecular structure ribbon cartoon showing helices, turns and sheets and their relations to each other in space.
has curation status: metadata complete
definition: A figure that expresses one or more propositions
definition editor: PERSON: Lawrence Hunter
imported from: iao.owl

document
type: Class
subclass of: information content entity
editor preferred label: document
example of usage: A journal article, patent application, laboratory notebook, or a book
has curation status: metadata complete
definition: A collection of information content entities intended to be understood together as a whole
definition editor: PERSON: Lawrence Hunter
imported from: iao.owl
imported from: ico.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

hypothesis textual entity
type: Class
subclass of: textual entity
editor preferred label: hypothesis textual entity
example of usage: that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper 'Pilot clinical study to evaluate the anticoagulant activity of fucoidan', by Lowenthal et. al.PMID:19696660
has curation status: metadata complete
definition: A textual entity that expresses an assertion that is intended to be tested.
editor note: 2009/09/28 Alan Ruttenberg. Fucoidan-use-case
definition editor: Person:Alan Ruttenberg
imported from: iao.owl

time measurement datum
type: Class
subclass of: scalar measurement datum
subclass of: Class
  intersection of: Restriction
    on property: has measurement unit label
    all values from: time unit
  intersection of: Restriction
    on property: is duration of
    all values from: process
has curation status: metadata incomplete
definition: A scalar measurement datum that is the result of measuring a temporal interval
editor note: 2009/09/28 Alan Ruttenberg. Fucoidan-use-case
definition editor: Person:Alan Ruttenberg
imported from: iao.owl

postal address
type: Class
subclass of: textual entity
subclass of: Restriction
  on property: is about
  some values from: geographic location
has curation status: metadata incomplete
definition: A textual entity that is used as directive to deliver something to a person, or organization
editor note: 2010-05-24 Alan Ruttenberg. Use label for the string representation. See issue https://github.com/information-artifact-ontology/IAO/issues/59
imported from: iao.owl

email address
type: Class
subclass of: information content entity
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
subclass of: Restriction
  on property: is about
  some values from: contact person
editor preferred label: email address
has curation status: metadata incomplete
editor note: Alan Ruttenberg 1/3/2012 - Provisional id, see issue at https://github.com/information-artifact-ontology/IAO/issues/130&thanks=130&ts=1325636583
definition editor: Person:Alan Ruttenberg
definition editor: Person:Chris Stoeckart
imported from: iao.owl

documenting
type: Class
subclass of: planned process
subclass of: Restriction
  on property: has_specified_input
  some values from: information content entity
subclass of: Restriction
  on property: has_specified_output
  some values from: document
example of usage: Recording the current temperature in a laboratory notebook. Writing a journal article. Updating a patient record in a database.
has curation status: pending final vetting
definition: A planned process in which a document is created or added to by including the specified input in it.
definition: a planned process in which a document is created or added to by including the specified input in it.
editor note: 6/11/9: Edited at OBI workshop. We need to be able identify a child form of information artifact which corresponds to something enduring (not brain like). This used to be restricted to physical document or digital entity as the output, but that excludes e.g. an audio cassette tape
definition editor: Bjoern Peters
definition source: wikipedia http://en.wikipedia.org/wiki/Documenting
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

line graph
type: Class
subclass of: graph
editor preferred label: line graph
has curation status: ready for release
definition: A line graph is a type of graph created by connecting a series of data points together with a line.
definition editor: PERSON:Chris Stoeckert
definition editor: PERSON:Melanie Courtot
alternative term: line chart
definition source: GROUP:OBI
definition source: WEB: http://en.wikipedia.org/wiki/Line_chart
imported from: iao.owl

assigning a centrally registered identifier
type: Class
subclass of: planned process
subclass of: Restriction
  on property: has_specified_output
  some values from: centrally registered identifier symbol
subclass of: Restriction
  on property: has_participant
  some values from: centrally registered identifier registry
example of usage: A new pubmed ID being created for a journal article, and the associated pubmed record containing information to the journal article. A license plate number registered at the DMV to be belonging to a specific vehicle and owner. Placing a barcode on a product and entering information in a database that this barcode is assigned.
has curation status: metadata complete
definition: A planned process in which a new CRID is created, associated with an entity, and stored in the CRID registry thereby registering it as being associated with some entity
editor note: 2014-05-05: It is the CRID registry that assigns CRIDs, not the users of the registry.
definition editor: Person:Alan Ruttenberg
definition editor: Person:Bjoern Peters
definition editor: Person:Melanie Courtot
alternative term: assigning a CRID
imported from: Ontology for Biomedical Investigations

centrally registered identifier symbol
type: Class
subclass of: symbol
subclass of: Restriction
  on property: part of
  some values from: CRID
example of usage: The sentence "The article has Pubmed ID 12345." contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed.
has curation status: metadata complete
definition: A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bill Hogan
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Melanie Courtot
alternative term: CRID symbol
definition source: Original proposal from Bjoern, discussions at IAO calls
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

CRID
type: Class
subclass of: information content entity
subclass of: Restriction
  on property: has part
  some values from: centrally registered identifier symbol
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: denotes
    some values from: centrally registered identifier registry
example of usage: Entries in a Column of which the header is "Pubmed ID"
example of usage: PMID:12345
example of usage: The following URL: "http://www.ncbi.nlm.nih.gov/pubmed/19918065"
example of usage: The following sentence contains a CRID: "The article with Pubmed ID: 19918065".
example of usage: The sentence "The article has Pubmed ID 12345." contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed.
has curation status: metadata complete
definition: An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs.
definition: An information content entity that consists of a CRID symbol and additional information about which CRID registry it belongs.
editor note: 2014-05-05: In defining this term we take no position on what the CRID denotes. In particular do not assume it denotes a *record* in the CRID registry (since the registry might not have 'records').
editor note: Alan, IAO call 20101124: potentially the CRID denotes the instance it was associated with during creation.
editor note: Note, IAO call 20101124: URIs are not always CRID, as not centrally registered. We acknowledge that CRID is a subset of a larger identifier class, but this subset fulfills our current needs. OBI PURLs are CRID as they are registered with OCLC. UPCs (Universal Product Codes from AC Nielsen)are not CRID as they are not centrally registered.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bill Hogan
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Melanie Courtot
alternative term: CRID
alternative term: Centrally Registered IDentifier
definition source: Original proposal from Bjoern, discussions at IAO calls
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl
label: centrally registered identifier

centrally registered identifier registry
type: Class
subclass of: data set
example of usage: PubMed is a CRID registry. It has a dataset of PubMed identifiers associated with journal articles.
has curation status: metadata complete
definition: A CRID registry is a dataset of CRID records, each consisting of a CRID symbol and additional information which was recorded in the dataset through a assigning a centrally registered identifier process.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bill Hogan
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Melanie Courtot
alternative term: CRID registry
definition source: Original proposal from Bjoern, discussions at IAO calls
imported from: iao.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

written name
type: Class
subclass of: textual entity
editor preferred label: written name
example of usage: "Bill Clinton"
example of usage: "The Eiffel Tower"
example of usage: "United States of America"
has curation status: pending final vetting
definition: A textual entity that denotes a particular in reality.
definition editor: PERSON: Bill Hogan
definition source: https://github.com/information-artifact-ontology/IAO/issues/114
curator note: The qualifier "written" is to set it apart from spoken names. Also, note the restrictions to particulars. We are not naming universals. We could however, be naming, attributive collections which are particulars, so "All people located in the boundaries of the city of Little Rock, AR on June 18, 2011 at 9:50a CDT" would be a name.
imported from: iao.owl

author information textual entity
type: Class
subclass of: textual entity
editor preferred label: author information textual entity
example of usage: From Takon. Ann Gen Psychiatry. 2011; 10: 25. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204268/): IT [the author] is the lead paediatrician for ADHD services in East Hertfordshire, UK, where she runs a weekly joint ADHD clinic with the Child and Adolescent psychiatrist and works within an ADHD specialist team. IT also sees children with other neurodisability issues who may have comorbid ADHD, where the presentation may be more complex and challenging to manage. IT has vast experience in managing children with complex ADHD. She has 18 years of experience in paediatrics and also has extensive experience in the use of psychopharmacologic agents in managing children with ADHD.
definition: A textual entity expression information about an author of a document. This information may include biographical information and may discuss how the authors' professional experiences are relevant to the work described in the document.
definition editor: PERSON: Bill Baumgartner
term tracker item: https://github.com/information-artifact-ontology/IAO/issues/183
imported from: iao.owl

case report textual entity
type: Class
subclass of: textual entity
editor preferred label: case report textual entity
example of usage: Excerpt from Taglia et al. Acta Myol. 2012 Dec; 31(3): 201–203. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631801/): The patient is a 50-year-old man. His medical history was not contributory. At the age of 37 years, he complained of persistent fatigue and dyspnoea even for modest efforts and oedema of lower limbs. The patient was examined at the department of internal medicine of the local hospital, and hospitalised with a diagnosis of dilated cardiomyopathy probably consequence of a myocarditis process. Soon after he was transferred to the cardiologic department of the regional hospital, and pharmacologically treated for heart failure and pulmonary hypertension.
definition: A textual entity that expresses a detailed account of a portion of the medical history for a specific patient.
definition editor: PERSON: Bill Baumgartner
term tracker item: https://github.com/information-artifact-ontology/IAO/issues/183
imported from: iao.owl

social act
type: Class
subclass of: process
subclass of: planned process
example of usage: Colonel Klink giving Sergeant Schultz an order, Jake promising Jill to take her to the junior prom
definition: A planned process that is carried out by a conscious being or an organization, and is self-generated, directed towards another conscious being or an aggregate of conscious beings, an organization or an aggregate of organizations, and that needs to be perceived.
definition: A process that is carried out by a conscious being or an aggregate of conscious beings and is spontaneous, directed towards other conscious beings and aggregates thereof and needs to be perceived.
definition editor: Mathias Brochhausen
imported from: ico.owl
imported from: omrse.owl
comment: MB: Regarding the use of the term 'sponteneous' in the definition: The term is used in the following meaning of being self generated. It does not stand in contrast to being planned.

socio-legal generically dependent continuant
type: Class
equivalent class: Restriction
  on property: is_specified_output_of
  some values from: declaration
subclass of: generically dependent continuant
example of usage: the claim of a piece of land, the obligation to pay rent to the owner of a rental property
definition: Socio-legal generically dependent continuants are generically dependent continuants that come into existence through declarations and are concretized as roles. They differ from information content entities in that they are not about something, but exist as quasi-abstract social entities. Socio-legal generically dependent continuants are not concretized as qualities inhering in independent continuants, but only as realizable entities borne by an organism or an aggregate of organisms.
definition editor: Mathias Brochhausen
imported from: omrse.owl

declaration
type: Class
equivalent class: Class
  intersection of: Class
    union of: Restriction
      on property: IAO_0021011
      some values from: Class
        union of: role
        union of: socio-legal generically dependent continuant
    union of: Restriction
      on property: IAO_0021012
      some values from: socio-legal generically dependent continuant
    union of: Restriction
      on property: has_specified_output
      some values from: Class
        union of: role
        union of: socio-legal generically dependent continuant
  intersection of: Restriction
    on property: realizes
    some values from: declaration performer role
  intersection of: Restriction
    on property: has active participant
    some values from: Class
      intersection of: Class
        union of: Homo sapiens
        union of: organization
        union of: collection of humans
        union of: aggregate of organizations
      intersection of: Restriction
        on property: bearer of
        some values from: declaration performer role
subclass of: social act
example of usage: my consenting verbally to buy a used TV set for $ 500, Jane Doe's signing of the divorce papers, John Robie's taking of Mrs. Steven's jewels
definition: A social act that brings about, transfers or revokes a socio-legal generically dependent continuant or brings about or revokes a role. Declarations do not depend on words spoken or written, but sometimes are merely actions, for instance the signing of a document.
definition editor: Mathias Brochhausen
imported from: omrse.owl

document act input document
type: Class
subclass of: document
definition: A document that is intended to be the specified input in a document act. It has a plan specification as a part that specifies the intended socio-legal entities that are created through the document (objective specification) and the way in which the document act is to be performed (by signing, by stamping, etc.) (action specification).
definition editor: Mathias Brochhausen
imported from: ico.owl

declaration performer role
type: Class
subclass of: role
subclass of: Class
  intersection of: Restriction
    on property: characteristic of
    some values from: Class
      union of: Homo sapiens
      union of: organization
      union of: collection of humans
      union of: aggregate of organizations
  intersection of: Restriction
    on property: realized in
    all values from: declaration
example of usage: a judge's role of signing a court order, a hospital committee's to sanction conformance to a specific guideline for hospital employees.
definition: A role inhering in a human being or an organization or an aggregate of any of the aforementioned that is realized by the bearer being the agent in a declaration.
definition editor: Mathias Brochhausen
imported from: omrse.owl

informed consent form
type: Class
equivalent class: Class
  union of: incomplete informed consent form
  union of: complete informed consent form indicating consent
subclass of: document act input document
definition: A document that explains all relevant information to assist a human being in understanding the expectations and requirements of participation in a process, and is an instrument in obtaining consent and, after having obtained consent, is a record that such a consent has occurred.
editor note: The term definition is adapted from NCIt definition of 'consent form' (C16468) with modification. For instance, whereas the NCIt definition restricted informed consent forms to clinical trials, the present definition does not.
definition editor: Alla Karnovsky, Frank Manion, Yongqun He, Asiyah Yu Lin, Marcy Harris, Elizabeth Eisenhauer, Jonathan Vajda, Cooper Stansbury, J. Neil Otte
alternative term: informed consent document
definition source: NCIt C16468
curator note: See curator note for 'incomplete informed consent form'.
imported from: ico.owl
term_mapping_to_UMLS: C0009797
term_mapping_to_NCIT: C16468

signing an informed consent form
type: Class
subclass of: social act
definition: A social act that is a part of an informed consent process and has output of a signed informed consent form. The signing process leads to a legal obligation.
definition editor: Alla Karnovsky, Frank Manion, Yongqun He, Jihad Obeid, Chris Stoeckert, and Mathias Brochhausen
curator note: This class is under group discussion as of 03/26/2019.
imported from: ico.owl
comment: Signing here does not mean that we have to sign with a pen. It may happen in terms of signing a piece of a paper or an electronic form.

incomplete informed consent form
type: Class
subclass of: informed consent form
definition: A document act input document that explains all relevant information to assist a human being in understanding the expectations and requirements of participation in a process, and whose purpose is to assist in obtaining consent.
definition editor: J. Neil Otte
imported from: ico.owl
comment: Note: instances of 'incomplete informed consent form' include both blank informed consent forms that are waiting to be used in a process of informed consent, as well as those that have been left blank by a patient, whether on purpose or in error. Those that have been left blank on purpose have been used in a process of informed consent, where the patient must have reached a decision.

complete informed consent form indicating consent
type: Class
subclass of: informed consent form
definition: A document act input document that has, as part, an incomplete informed consent form, along with some additional parts, such as a signature, stamp, or initials, which serve as a record to an act of consent that had the incomplete informed consent form as a specified input.
definition editor: J. Neil Otte
imported from: ico.owl

signature
type: Class
subclass of: information content entity
definition: An information content entity that is a handwritten depiction of a name.
definition editor: Jonathan Vajda, Cooper Stansbury, J. Neil Otte.
imported from: ico.owl

acute kidney failure
type: Class
subclass of: kidney disease
definition: Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria.
imported from: mondo.owl
database_cross_reference: DOID:3021
database_cross_reference: ICD10:N17
database_cross_reference: MESH:D058186
database_cross_reference: NCIT:C26808
has exact synonym: AKI
has exact synonym: ARF
has exact synonym: acute kidney injury
has exact synonym: acute renal failure
has exact synonym: kidney failure, acute
id: MONDO:0002492

diabetic nephropathy
type: Class
subclass of: chronic kidney disease
definition: Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis.
imported from: mondo.owl
database_cross_reference: EFO:0000401
database_cross_reference: ICD9:250.4
database_cross_reference: ICD9:250.40
database_cross_reference: ICD9:583.81
database_cross_reference: MESH:D003928
database_cross_reference: NCIT:C84417
database_cross_reference: SCTID:127013003
has exact synonym: diabetic Nephropathy
has exact synonym: diabetic kidney disease
id: MONDO:0005016

kidney disease
type: Class
subclass of: disease
definition: A disease involving the kidney.
imported from: mondo.owl
database_cross_reference: DOID:557
database_cross_reference: EFO:0003086
database_cross_reference: ICD10:N08
database_cross_reference: ICD10:N28.9
database_cross_reference: ICD9:583.81
database_cross_reference: MESH:D007674
database_cross_reference: NCIT:C3149
database_cross_reference: SCTID:90708001
database_cross_reference: UMLS:C0022658
has exact synonym: disease of kidney
has exact synonym: disease or disorder of kidney
has exact synonym: disorder of kidney
has exact synonym: kidney disease
has exact synonym: kidney disease or disorder
has exact synonym: kidney disorder
has exact synonym: nephropathy
has exact synonym: renal disease
has exact synonym: renal disorder
has_related_synonym: disorder of kidney
id: MONDO:0005240

chronic kidney disease
type: Class
subclass of: kidney disease
definition: Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.
imported from: mondo.owl
database_cross_reference: COHD:46271022
database_cross_reference: DOID:784
database_cross_reference: EFO:0003884
database_cross_reference: ICD10:N18.9
database_cross_reference: ICD9:585
database_cross_reference: ICD9:585.6
database_cross_reference: MESH:D007676
database_cross_reference: NCIT:C80078
database_cross_reference: SCTID:709044004
database_cross_reference: UMLS:C0022661
has exact synonym: CKD
has exact synonym: CKD - chronic kidney disease
has exact synonym: chronic kidney disease
has exact synonym: chronic kidney failure
has exact synonym: chronic renal disease
has exact synonym: kidney disease, chronic
has exact synonym: renal failure - chronic
has_narrow_synonym: chronic renal failure syndrome
has_related_synonym: chronic renal insufficiency
id: MONDO:0005300

Viruses
type: Class
subclass of: organism
subclass of: acellular self-replicating organic structure
editor preferred label: Viruses
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has_rank: NCBITaxon superkingdom
database_cross_reference: GC_ID:1
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Vira
has_related_synonym: Viridae
has_related_synonym: viruses

Teleostomi
type: Class
subclass of: Gnathostomata <vertebrate>
imported from: envo.owl

Euteleostomi
type: Class
subclass of: Teleostomi
subclass of: Vertebrata <Metazoa>
subclass of: Gnathostomata <vertebrate>
editor preferred label: Euteleostomi
alternative term: bony vertebrates
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has exact synonym: bony vertebrates

Dipnotetrapodomorpha
type: Class
subclass of: Euteleostomi
subclass of: Sarcopterygii
imported from: envo.owl

Boreoeutheria
type: Class
subclass of: Eutheria
imported from: envo.owl
has_related_synonym: Boreotheria

Bacteria
type: Class
subclass of: organism
subclass of: cellular organism
editor preferred label: Bacteria
alternative term: eubacteria
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has_rank: NCBITaxon superkingdom
database_cross_reference: GC_ID:11
database_cross_reference: PMID:10425795
database_cross_reference: PMID:10425796
database_cross_reference: PMID:10425797
database_cross_reference: PMID:10490293
database_cross_reference: PMID:10843050
database_cross_reference: PMID:10939651
database_cross_reference: PMID:10939673
database_cross_reference: PMID:10939677
database_cross_reference: PMID:11211268
database_cross_reference: PMID:11321083
database_cross_reference: PMID:11321113
database_cross_reference: PMID:11411719
database_cross_reference: PMID:11540071
database_cross_reference: PMID:11542017
database_cross_reference: PMID:11542087
database_cross_reference: PMID:11760965
database_cross_reference: PMID:12054223
database_cross_reference: PMID:2112744
database_cross_reference: PMID:270744
database_cross_reference: PMID:7520741
database_cross_reference: PMID:8123559
database_cross_reference: PMID:8186100
database_cross_reference: PMID:8590690
database_cross_reference: PMID:9103655
database_cross_reference: PMID:9336922
has exact synonym: eubacteria
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Monera
has_related_synonym: Procaryotae
has_related_synonym: Prokaryota
has_related_synonym: Prokaryotae
has_related_synonym: bacteria
has_related_synonym: not Bacteria Haeckel 1894
has_related_synonym: prokaryote
has_related_synonym: prokaryotes

Homininae
type: Class
subclass of: Hominidae
imported from: envo.owl
has_related_synonym: Homo/Pan/Gorilla group

Archaea
type: Class
subclass of: organism
subclass of: cellular organism
editor preferred label: Archaea
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has_rank: NCBITaxon superkingdom
database_cross_reference: GC_ID:11
database_cross_reference: PMID:10425795
database_cross_reference: PMID:10425796
database_cross_reference: PMID:10425797
database_cross_reference: PMID:10490293
database_cross_reference: PMID:10843050
database_cross_reference: PMID:10939651
database_cross_reference: PMID:10939673
database_cross_reference: PMID:10939677
database_cross_reference: PMID:11211268
database_cross_reference: PMID:11321083
database_cross_reference: PMID:11321113
database_cross_reference: PMID:11411719
database_cross_reference: PMID:11540071
database_cross_reference: PMID:11541975
database_cross_reference: PMID:11542064
database_cross_reference: PMID:11542149
database_cross_reference: PMID:11760965
database_cross_reference: PMID:12054223
database_cross_reference: PMID:2112744
database_cross_reference: PMID:25527841
database_cross_reference: PMID:270744
database_cross_reference: PMID:8123559
database_cross_reference: PMID:8590690
database_cross_reference: PMID:9103655
database_cross_reference: PMID:9336922
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Archaebacteria
has_related_synonym: Mendosicutes
has_related_synonym: Metabacteria
has_related_synonym: Monera
has_related_synonym: Procaryotae
has_related_synonym: Prokaryota
has_related_synonym: Prokaryotae
has_related_synonym: archaea
has_related_synonym: prokaryote
has_related_synonym: prokaryotes

Eukaryota
type: Class
subclass of: organism
subclass of: cellular organism
editor preferred label: Eukaryota
alternative term: eucaryotes
alternative term: eukaryotes
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has_rank: NCBITaxon superkingdom
has rank: NCBITaxon superkingdom
database_cross_reference: GC_ID:1
database_cross_reference: PMID:23020233
database_cross_reference: PMID:30257078
has exact synonym: eucaryotes
has exact synonym: eukaryotes
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Eucarya
has_related_synonym: Eucaryotae
has_related_synonym: Eukarya
has_related_synonym: Eukaryotae
has_related_synonym: eukaryotes
id: NCBITaxon:2759

Euarchontoglires
type: Class
subclass of: Boreoeutheria
subclass of: Mammalia
editor preferred label: Euarchontoglires
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations

Simiiformes
type: Class
subclass of: Euarchontoglires
subclass of: Haplorrhini
imported from: envo.owl
has_related_synonym: Anthropoidea

Hominoidea
type: Class
subclass of: Catarrhini
imported from: envo.owl
has exact synonym: ape
has exact synonym: apes

Tetrapoda
type: Class
subclass of: Euteleostomi
subclass of: Dipnotetrapodomorpha
editor preferred label: Tetrapoda
alternative term: tetrapods
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has exact synonym: tetrapods

Amniota
type: Class
subclass of: Tetrapoda
editor preferred label: Amniota
alternative term: amniotes
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has exact synonym: amniotes

Theria <Mammalia>
type: Class
subclass of: Mammalia
imported from: envo.owl
has exact synonym: Theria

Opisthokonta
type: Class
subclass of: Eukaryota
editor preferred label: Opisthokonta
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
database_cross_reference: GC_ID:1
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Fungi/Metazoa group
has_related_synonym: opisthokonts
id: NCBITaxon:33154

Metazoa
type: Class
subclass of: Opisthokonta
imported from: envo.owl
has exact synonym: metazoans
has exact synonym: multicellular animals
has_related_synonym: Animalia
has_related_synonym: animals

Bilateria
type: Class
subclass of: Opisthokonta
subclass of: Eumetazoa
editor preferred label: Bilateria
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations

Deuterostomia
type: Class
subclass of: Bilateria
imported from: envo.owl
has exact synonym: deuterostomes

prion
type: Class
subclass of: acellular self-replicating organic structure
definition: A misfolded protein that has the ability to transmit its misfolded shape onto normal variants of the same protein.
definition source: https://en.wikipedia.org/wiki/Prion
imported from: ncbitaxon.owl
has_rank: NCBITaxon species
database_cross_reference: GC_ID:1
has_obo_namespace: ncbi_taxonomy

Haplorrhini
type: Class
subclass of: Primates
imported from: envo.owl

Mammalia
type: Class
subclass of: Amniota
editor preferred label: Mammalia
alternative term: mammals
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has exact synonym: mammals
has_related_synonym: mammals

Eumetazoa
type: Class
subclass of: Metazoa
imported from: envo.owl

Chordata
type: Class
subclass of: Deuterostomia
imported from: envo.owl
has exact synonym: chordates
has_related_synonym: chordates

Vertebrata <Metazoa>
type: Class
subclass of: Bilateria
subclass of: Chordata
subclass of: Craniata <chordata>
editor preferred label: Vertebrata <vertebrates>
alternative term: Vertebrata
alternative term: vertebrates
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
has exact synonym: Vertebrata
has exact synonym: vertebrates
has_related_synonym: vertebrates
label: Vertebrata <vertebrates>

Gnathostomata <vertebrate>
type: Class
subclass of: Vertebrata <Metazoa>
imported from: envo.owl
has exact synonym: Gnathostomata
has exact synonym: jawed vertebrates

Sarcopterygii
type: Class
subclass of: Euteleostomi
imported from: envo.owl

Craniata <chordata>
type: Class
subclass of: Chordata
imported from: envo.owl
has exact synonym: Craniata

Eutheria
type: Class
subclass of: Theria <Mammalia>
imported from: envo.owl
has exact synonym: eutherian mammals
has exact synonym: placental mammals
has exact synonym: placentals
has_related_synonym: Placentalia
has_related_synonym: placentals

Primates
type: Class
subclass of: Euarchontoglires
imported from: envo.owl
has exact synonym: primate
has_related_synonym: Primata
has_related_synonym: primates

Catarrhini
type: Class
subclass of: Simiiformes
imported from: envo.owl

Hominidae
type: Class
subclass of: Hominoidea
imported from: envo.owl
has exact synonym: great apes
has_related_synonym: Pongidae

Homo
type: Class
subclass of: Homininae
imported from: envo.owl
has exact synonym: humans

Homo sapiens
type: Class
subclass of: Eukaryota
subclass of: Euarchontoglires
subclass of: Catarrhini
subclass of: Homo
subclass of: Restriction
  on property: has quality
  some values from: biological sex
editor preferred label: Homo sapiens
alternative term: human
alternative term: human being
alternative term: man
alternative term: person
imported from: envo.owl
imported from: ncbitaxon.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl
has_rank: NCBITaxon species
database_cross_reference: GC_ID:1
has exact synonym: human
has exact synonym: man
has_obo_namespace: ncbi_taxonomy
has_related_synonym: humans

Number of Siblings
type: Class
subclass of: Socioeconomic Factors
definition: An individual's total number of brothers and sisters.
imported from: ncit.owl
code: C102469
Semantic_Type: Qualitative Concept
Preferred_Name: Number of Siblings
UMLS_CUI: C0557094
Contributing_Source: FDA
has exact synonym: Number of Siblings
in subset: NCIT C54447
in subset: NCIT C88088

Age at Time of Vaccination
type: Class
subclass of: Age
definition: The age of the subject at the time of the vaccination.
imported from: ncit.owl
code: C103173
Semantic_Type: Organism Attribute
Preferred_Name: Age at Time of Vaccination
UMLS_CUI: C3641107
Contributing_Source: FDA
has exact synonym: Age at Time of Vaccination
has exact synonym: Age at the Time of Vaccination
in subset: NCIT C54447
in subset: NCIT C88088

Religious Group
type: Class
subclass of: Population Group
definition: A group of people characterized by the practice of a common religion.
imported from: ncit.owl
code: C103282
Semantic_Type: Population Group
Preferred_Name: Religious Group
UMLS_CUI: C0597369
has exact synonym: Religious Group

Sephardic Jew
type: Class
subclass of: Religious Group
subclass of: Ethnic Group
definition: A member of the Jewish faith whose ancestors lived in North Africa, the Middle East, Portugal or Spain.
imported from: ncit.owl
code: C103283
Semantic_Type: Population Group
Preferred_Name: Sephardic Jew
UMLS_CUI: C0574825
ALT_DEFINITION: A person of Sephardic Jewish descent.
has exact synonym: SEPHARDIC JEW
has exact synonym: Sephardi
has exact synonym: Sephardic Jew
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Other Race
type: Class
subclass of: Race
definition: Individuals who do not necessarily identify with any particular race or others who do not wish to self select into a racial category(ies).
imported from: ncit.owl
code: C104495
Semantic_Type: Population Group
Preferred_Name: Other Race
UMLS_CUI: C0425379
has exact synonym: OTHER RACE
has exact synonym: Other Race
has exact synonym: RACEOTH
in subset: NCIT C83187

Age at Menopause
type: Class
subclass of: Age
definition: The age at which permanent cessation of menses occurs.
imported from: ncit.owl
code: C106497
Semantic_Type: Clinical Attribute
Preferred_Name: Age at Menopause
UMLS_CUI: C1629609
Contributing_Source: CDISC
ALT_DEFINITION: The age at which permanent cessation of menses occurred. (NCI)
has exact synonym: Age at Menopause
has exact synonym: MENOAGE
has exact synonym: Menopause Age
in subset: NCIT C106478
in subset: NCIT C106479
in subset: NCIT C61410
in subset: NCIT C66830

Other Asian
type: Class
subclass of: Asian
definition: A person having origins in the original peoples of Asia, but not China, India, Korea, the Philippine Islands or Vietnam.
imported from: ncit.owl
code: C107601
Semantic_Type: Population Group
Preferred_Name: Other Asian
UMLS_CUI: C0438971
Contributing_Source: FDA
has exact synonym: Other Asian

Other Pacific Islander
type: Class
subclass of: Native Hawaiian or Other Pacific Islander
definition: A person having origins in the original peoples of the Pacific Islands, but not Guam, Hawaii, the Mariana Islands or Samoa.
imported from: ncit.owl
code: C107602
Semantic_Type: Population Group
Preferred_Name: Other Pacific Islander
UMLS_CUI: C1553351
Contributing_Source: FDA
has exact synonym: Other Pacific Islander

Mexican or Mexican American
type: Class
subclass of: Hispanic or Latino
definition: A person of Mexican or Mexican American culture or origin, regardless of race.
imported from: ncit.owl
code: C107607
Semantic_Type: Population Group
Preferred_Name: Mexican or Mexican American
UMLS_CUI: C3829110
Contributing_Source: FDA
has exact synonym: Mexican or Mexican American

Cuban
type: Class
subclass of: Hispanic or Latino
definition: A person of Cuban culture or origin, regardless of race.
imported from: ncit.owl
code: C107608
Semantic_Type: Population Group
Preferred_Name: Cuban
UMLS_CUI: C1553379
Contributing_Source: FDA
ALT_DEFINITION: A person of Cuban descent.
has exact synonym: CUBAN
has exact synonym: Cuban
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Other Hispanic or Latino(a)
type: Class
subclass of: Hispanic or Latino
definition: A person of Spanish culture or origin, but not Cuban, Mexican, Puerto Rican, South or Central American, regardless of race.
imported from: ncit.owl
code: C107609
Semantic_Type: Population Group
Preferred_Name: Other Hispanic or Latino(a)
UMLS_CUI: C3828691
Contributing_Source: FDA
has exact synonym: Other Hispanic or Latino(a)

Conception Age
type: Class
subclass of: Age
definition: The time elapsed between the day of conception and the day of delivery.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C89335
code: C114088
Semantic_Type: Organism Attribute
Preferred_Name: Conception Age
UMLS_CUI: C3827345
Contributing_Source: NICHD
ALT_DEFINITION: The time elapsed between the day of conception and the day of delivery.
NICHD_Hierarchy_Term: Conception Age
has exact synonym: Conception Age
has exact synonym: Conceptional Age
has exact synonym: Conceptual Age
has exact synonym: Post-Conceptional Age
has exact synonym: Post-Conceptual Age
in subset: NCIT C118466
in subset: NCIT C90259

Corrected Age
type: Class
subclass of: Age
definition: Chronological age reduced by the number of weeks born before 40 weeks of gestation; most appropriately used to describe children up to 3 years of age who were born preterm.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C89335
code: C114089
Semantic_Type: Organism Attribute
Preferred_Name: Corrected Age
UMLS_CUI: C3831006
Contributing_Source: NICHD
ALT_DEFINITION: Chronological age reduced by the number of weeks born before 40 weeks of gestation; most appropriately used to describe children up to 3 years of age who were born preterm.
NICHD_Hierarchy_Term: Corrected Age
has exact synonym: Adjusted Age
has exact synonym: Corrected Age
has exact synonym: Corrected Gestational Age
in subset: NCIT C118466
in subset: NCIT C90259

Postmenstrual Age
type: Class
subclass of: Age
definition: Best estimate of the first day of last menstrual period to birth plus time elapsed from day of birth.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C89335
code: C114090
Semantic_Type: Organism Attribute
Preferred_Name: Postmenstrual Age
UMLS_CUI: C3828508
Contributing_Source: NICHD
ALT_DEFINITION: Best estimate of the first day of last menstrual period to birth plus time elapsed from day of birth.
NICHD_Hierarchy_Term: Postmenstrual Age
has exact synonym: Postmenstrual Age
in subset: NCIT C118466
in subset: NCIT C90259

Very Low Birth Weight
type: Class
subclass of: Birth Weight (NCIT)
definition: Birth weight less than 1500 grams.
imported from: ncit.owl
Has_NICHD_Parent: Birth Weight (NCIT)
code: C114935
Semantic_Type: Finding
Preferred_Name: Very Low Birth Weight
UMLS_CUI: C0282666
Contributing_Source: GAIA
Contributing_Source: NICHD
ALT_DEFINITION: Birth weight less than 1500 grams.
NICHD_Hierarchy_Term: Very Low Birth Weight
has exact synonym: VLBW
has exact synonym: Very Low Birth Weight
in subset: NCIT C118466
in subset: NCIT C125481
in subset: NCIT C128701
in subset: NCIT C90259

Extremely Low Birth Weight
type: Class
subclass of: Birth Weight (NCIT)
definition: Birth weight less than 1000 grams.
imported from: ncit.owl
Has_NICHD_Parent: Birth Weight (NCIT)
code: C114936
Semantic_Type: Finding
Preferred_Name: Extremely Low Birth Weight
UMLS_CUI: C0456065
Contributing_Source: GAIA
Contributing_Source: NICHD
ALT_DEFINITION: Birth weight less than 1000 grams.
NICHD_Hierarchy_Term: Extremely Low Birth Weight
has exact synonym: ELBW
has exact synonym: Extremely Low Birth Weight
in subset: NCIT C118466
in subset: NCIT C125481
in subset: NCIT C128701
in subset: NCIT C90259

Ultra Low Birth Weight
type: Class
subclass of: Birth Weight (NCIT)
definition: Birth weight less than 750 grams.
imported from: ncit.owl
code: C114937
Semantic_Type: Finding
Preferred_Name: Ultra Low Birth Weight
UMLS_CUI: C3896584
has exact synonym: ULBW
has exact synonym: Ultra Low Birth Weight

Ideal Body Weight
type: Class
subclass of: Body Weight
definition: A person's optimum weight as calculated by a standard methodology.
imported from: ncit.owl
code: C117976
Semantic_Type: Quantitative Concept
Preferred_Name: Ideal Body Weight
UMLS_CUI: C0421272
Contributing_Source: CDISC
ALT_DEFINITION: A person's optimum weight as calculated by a standard methodology.
has exact synonym: IDEALWT
has exact synonym: Ideal Body Weight
in subset: NCIT C61410
in subset: NCIT C66741
in subset: NCIT C66830
in subset: NCIT C67153
in subset: NCIT C77526

Social Security Retirement Benefit
type: Class
subclass of: Income
definition: The money received by retired workers who have paid in to the Social Security system during their working years.
imported from: ncit.owl
code: C120451
Semantic_Type: Group Attribute
Preferred_Name: Social Security Retirement Benefit
UMLS_CUI: C0037435
has exact synonym: Social Security
has exact synonym: Social Security Retirement Benefit

Pension
type: Class
subclass of: Income
definition: A fixed sum paid regularly to a person by their former employer.
imported from: ncit.owl
code: C120452
Semantic_Type: Group Attribute
Preferred_Name: Pension
UMLS_CUI: C0030854
has exact synonym: Pension

Left Ventricular End Diastolic Pressure
type: Class
subclass of: Diastolic Blood Pressure
definition: The pressure within the left ventricle following the completion of diastolic filling, just prior to systole.
imported from: ncit.owl
code: C120919
Semantic_Type: Quantitative Concept
Preferred_Name: Left Ventricular End Diastolic Pressure
UMLS_CUI: C0456190
Contributing_Source: CDISC
ALT_DEFINITION: The pressure within the left ventricle of the heart at the end of the period when the chambers of the heart refill with blood and just before the contraction begins.
has exact synonym: LVEDP
has exact synonym: Left Ventricular End Diastolic Pressure
in subset: NCIT C120532
in subset: NCIT C120533
in subset: NCIT C61410
in subset: NCIT C77526

Left Ventricular Systolic Pressure
type: Class
subclass of: Systolic Blood Pressure
definition: The pressure in the left ventricle at any point prior to the ejection of its contents into the aorta (systole).
imported from: ncit.owl
code: C120920
Semantic_Type: Quantitative Concept
Preferred_Name: Left Ventricular Systolic Pressure
UMLS_CUI: C0456189
Contributing_Source: CDISC
ALT_DEFINITION: The pressure within the left ventricle of the heart during the contraction of the left ventricle of the heart.
has exact synonym: LVSYSBP
has exact synonym: Left Ventricular Systolic Pressure
in subset: NCIT C120532
in subset: NCIT C120533
in subset: NCIT C61410
in subset: NCIT C77526

Estimated Gestational Age
type: Class
subclass of: Age
definition: An approximate calculation of the gestational age of the fetus.
imported from: ncit.owl
code: C122188
Semantic_Type: Organism Attribute
Preferred_Name: Estimated Gestational Age
UMLS_CUI: C0262472
Contributing_Source: CDISC
ALT_DEFINITION: An approximate calculation of the gestational age of the fetus.
has exact synonym: EGESTAGE
has exact synonym: Estimated Gestational Age
in subset: NCIT C106478
in subset: NCIT C106479
in subset: NCIT C61410
in subset: NCIT C66830

Number of Years of Education
type: Class
subclass of: Socioeconomic Factors
definition: The number of education years that a subject has competed.
imported from: ncit.owl
code: C122393
Semantic_Type: Qualitative Concept
Preferred_Name: Number of Years of Education
UMLS_CUI: C4054327
Contributing_Source: CDISC
ALT_DEFINITION: The number of years of education that a person has completed.
has exact synonym: EDUYRNUM
has exact synonym: Number of Years of Education
in subset: NCIT C103330
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C74559

Age at First Episode
type: Class
subclass of: Age
definition: The age at which the first episode occurred.
imported from: ncit.owl
code: C124438
Semantic_Type: Organism Attribute
Preferred_Name: Age at First Episode
UMLS_CUI: C4085940
Contributing_Source: CDISC
ALT_DEFINITION: The age at which the first episode occurred.
has exact synonym: AGEEPSD1
has exact synonym: Age At First Episode
has exact synonym: Age at First Episode
in subset: NCIT C124302
in subset: NCIT C124303
in subset: NCIT C61410
in subset: NCIT C66830

Age at First Hospitalization
type: Class
subclass of: Age
definition: The age at which the first hospitalization event occurred.
imported from: ncit.owl
code: C124439
Semantic_Type: Organism Attribute
Preferred_Name: Age at First Hospitalization
UMLS_CUI: C4085941
Contributing_Source: CDISC
ALT_DEFINITION: The age at which the first hospitalization event occurred.
has exact synonym: AGEHOSP1
has exact synonym: Age At First Hospitalization
has exact synonym: Age at First Hospitalization
in subset: NCIT C124302
in subset: NCIT C124303
in subset: NCIT C61410
in subset: NCIT C66830

Age at First Treatment
type: Class
subclass of: Age
definition: The age at which the first treatment event occurred.
imported from: ncit.owl
code: C124440
Semantic_Type: Organism Attribute
Preferred_Name: Age at First Treatment
UMLS_CUI: C4085942
Contributing_Source: CDISC
ALT_DEFINITION: The age at which the first treatment for the condition occurred.
has exact synonym: AGETRT1
has exact synonym: Age At First Treatment
has exact synonym: Age at First Treatment
in subset: NCIT C124302
in subset: NCIT C124303
in subset: NCIT C61410
in subset: NCIT C66830

Gravid Uterus Adjusted Maternal Body Weight
type: Class
subclass of: Body Weight
definition: The maternal body weight adjusted for the weight of the gravid uterus. This is derived by subtracting the gravid uterus weight from the total maternal body weight.
imported from: ncit.owl
code: C124477
Semantic_Type: Conceptual Entity
Preferred_Name: Gravid Uterus Adjusted Maternal Body Weight
UMLS_CUI: C4086368
Contributing_Source: CDISC
ALT_DEFINITION: The maternal body weight adjusted for the weight of the gravid uterus. This is derived by subtracting the gravid uterus weight from the total maternal body weight.
has exact synonym: BWADJGU
has exact synonym: Gravid Uterus Adjusted Body Weight
has exact synonym: Gravid Uterus Adjusted Maternal Body Weight
in subset: NCIT C61410
in subset: NCIT C77526
in subset: NCIT C89961
in subset: NCIT C89962

Fetal Body Weight
type: Class
subclass of: Body Weight
definition: An estimate or direct measurement of the heaviness of a fetus.
imported from: ncit.owl
code: C124479
Semantic_Type: Conceptual Entity
Preferred_Name: Fetal Body Weight
UMLS_CUI: C0751992
Contributing_Source: CDISC
ALT_DEFINITION: The weight of a fetus.
has exact synonym: BWFETAL
has exact synonym: Fetal Body Weight
in subset: NCIT C124311
in subset: NCIT C124312
in subset: NCIT C61410
in subset: NCIT C77526

Average Live Fetal Weight
type: Class
subclass of: Body Weight
definition: A measurement of the average weight of all live fetuses.
imported from: ncit.owl
code: C124627
Semantic_Type: Conceptual Entity
Preferred_Name: Average Live Fetal Weight
UMLS_CUI: C4086012
Contributing_Source: CDISC
ALT_DEFINITION: A measurement of the average weight of all live fetuses.
has exact synonym: Average Live Fetal Weight
has exact synonym: FWAVGL
in subset: NCIT C124324
in subset: NCIT C124325
in subset: NCIT C61410
in subset: NCIT C77526

Average Female Live Fetal Weight
type: Class
subclass of: Body Weight
definition: A measurement of the average weight of all live female fetuses.
imported from: ncit.owl
code: C124628
Semantic_Type: Conceptual Entity
Preferred_Name: Average Female Live Fetal Weight
UMLS_CUI: C4086011
Contributing_Source: CDISC
ALT_DEFINITION: A measurement of the average weight of all live female fetuses.
has exact synonym: Average Female Live Fetal Weight
has exact synonym: FWAVGLF
in subset: NCIT C124324
in subset: NCIT C124325
in subset: NCIT C61410
in subset: NCIT C77526

Average Male Live Fetal Weight
type: Class
subclass of: Body Weight
definition: A measurement of the average weight of all live male fetuses.
imported from: ncit.owl
code: C124629
Semantic_Type: Conceptual Entity
Preferred_Name: Average Male Live Fetal Weight
UMLS_CUI: C4086996
Contributing_Source: CDISC
ALT_DEFINITION: A measurement of the average weight of all live male fetuses.
has exact synonym: Average Male Live Fetal Weight
has exact synonym: FWAVGLM
in subset: NCIT C124324
in subset: NCIT C124325
in subset: NCIT C61410
in subset: NCIT C77526

Total Live Fetal Weight
type: Class
subclass of: Body Weight
definition: A measurement of the total weight of all live fetuses.
imported from: ncit.owl
code: C124630
Semantic_Type: Conceptual Entity
Preferred_Name: Total Live Fetal Weight
UMLS_CUI: C4086909
Contributing_Source: CDISC
ALT_DEFINITION: A measurement of the total weight of all live fetuses.
has exact synonym: FWTOTL
has exact synonym: Total Live Fetal Weight
in subset: NCIT C124324
in subset: NCIT C124325
in subset: NCIT C61410
in subset: NCIT C77526

Age of Majority
type: Class
subclass of: Age
definition: The age at which a minor assumes legal control over their person, actions, and decisions.
imported from: ncit.owl
code: C126362
Semantic_Type: Organism Attribute
Preferred_Name: Age of Majority
NCI_META_CUI: CL504920
has exact synonym: Age of Majority

Central African
type: Class
subclass of: African
definition: Denotes a person whose ancestry is in any of the countries of the central part of the African continent: Burundi, the Central African Republic, Chad, the Democratic Republic of the Congo, and Rwanda.
imported from: ncit.owl
code: C126528
Semantic_Type: Population Group
Preferred_Name: Central African
UMLS_CUI: C0238602
has exact synonym: Central African

North African
type: Class
subclass of: African
definition: Denotes a person whose ancestry is in any of the countries of the northern part of the African continent: Algeria, Egypt, Libya, Morocco, Sudan, Tunisia, and Western Sahara.
imported from: ncit.owl
code: C126529
Semantic_Type: Population Group
Preferred_Name: North African
UMLS_CUI: C0238604
has exact synonym: North African

South African
type: Class
subclass of: African
definition: Denotes a person whose ancestry is in the country of South Africa.
imported from: ncit.owl
code: C126530
Semantic_Type: Population Group
Preferred_Name: South African
UMLS_CUI: C0238605
has exact synonym: South African

Latin American
type: Class
subclass of: Race
definition: Denotes a person whose ancestry is in any of the countries of the Americas or the Caribbean where Spanish or Portuguese is spoken.
imported from: ncit.owl
code: C126531
Semantic_Type: Population Group
Preferred_Name: Latin American
UMLS_CUI: C1553378
ALT_DEFINITION: A person of Latin American descent.
has exact synonym: LATIN AMERICAN
has exact synonym: Latin American
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

South American
type: Class
subclass of: Race
definition: Denotes a person whose ancestry is in any of the countries of South America.
imported from: ncit.owl
code: C126532
Semantic_Type: Population Group
Preferred_Name: South American
UMLS_CUI: C0425359
ALT_DEFINITION: A person of South American descent.
has exact synonym: SOUTH AMERICAN
has exact synonym: South American
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Southeast Asian
type: Class
subclass of: Asian
definition: Denotes a person whose ancestry is in any of the Asian countries south of China, east of India, west of New Guinea and north of Australia.
imported from: ncit.owl
code: C126533
Semantic_Type: Population Group
Preferred_Name: Southeast Asian
UMLS_CUI: C0238697
has exact synonym: Southeast Asian

Central Asian
type: Class
subclass of: Asian
definition: Denotes a person whose ancestry is in any of the Asian countries between the Caspian Sea in the west, China in the east, Afghanistan in the south, and Russia in the north.
imported from: ncit.owl
code: C126534
Semantic_Type: Population Group
Preferred_Name: Central Asian
UMLS_CUI: C0238696
has exact synonym: Central Asian

Australian
type: Class
subclass of: Race
definition: Denotes a person whose ancestry is in the country or continent of Australia.
imported from: ncit.owl
code: C126535
Semantic_Type: Population Group
Preferred_Name: Australian
UMLS_CUI: C0238711
has exact synonym: Australian

New Zealander
type: Class
subclass of: Race
definition: Denotes a person whose ancestry is in the country of New Zealand.
imported from: ncit.owl
code: C126536
Semantic_Type: Population Group
Preferred_Name: New Zealander
NCI_META_CUI: CL505027
has exact synonym: New Zealander

Icelander
type: Class
subclass of: Race
definition: Denotes a person whose ancestry is in the country of Iceland.
imported from: ncit.owl
code: C126537
Semantic_Type: Population Group
Preferred_Name: Icelander
UMLS_CUI: C0337808
has exact synonym: Icelander
has exact synonym: Icelandic

Scandinavian
type: Class
subclass of: Race
definition: Denotes a person whose ancestry is in the countries of Scandinavia: Denmark, Norway and Sweden. Finland and Iceland are generally included as part of the Scandinavian region.
imported from: ncit.owl
code: C126538
Semantic_Type: Population Group
Preferred_Name: Scandinavian
UMLS_CUI: C0240951
has exact synonym: Scandinavian

American Ethnicity
type: Class
subclass of: Ethnic Group
definition: A collection of ethnic geographical categories including African American, North American, Latin American, Caribbean, and South American.
imported from: ncit.owl
code: C128457
Semantic_Type: Population Group
Preferred_Name: American Ethnicity
UMLS_CUI: C0596070
has exact synonym: American
has exact synonym: American Ethnicity
has exact synonym: Americas

Australian/New Zealand Ethnicity
type: Class
subclass of: Ethnic Group
definition: A collection of ethnic geographical categories including Australian and New Zealander.
imported from: ncit.owl
code: C128458
Semantic_Type: Population Group
Preferred_Name: Australian/New Zealand Ethnicity
NCI_META_CUI: CL509688
has exact synonym: Australian/New Zealand
has exact synonym: Australian/New Zealand Ethnicity

Intercontinental Ethnicity
type: Class
subclass of: Ethnic Group
definition: A collection of ethnic geographical categories including Middle Eastern and Hispanic.
imported from: ncit.owl
code: C128459
Semantic_Type: Population Group
Preferred_Name: Intercontinental Ethnicity
NCI_META_CUI: CL509475
has exact synonym: Intercontinental
has exact synonym: Intercontinental Ethnicity

African American
type: Class
subclass of: Black or African American
definition: Denotes a person of African ancestral origins whose family settled in America.
imported from: ncit.owl
code: C128937
Semantic_Type: Population Group
Preferred_Name: African American
NCI_META_CUI: CL415133
ALT_DEFINITION: A person having origins in the original peoples of sub-Saharan Africa and the United States.
has exact synonym: AFRICAN AMERICAN
has exact synonym: African American
has exact synonym: Afro American
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Black
type: Class
subclass of: Black or African American
imported from: ncit.owl
code: C128938
Semantic_Type: Population Group
Preferred_Name: Black
UMLS_CUI: C0005680
Contributing_Source: CDISC
ALT_DEFINITION: A person having origins in the original peoples of sub-Saharan Africa or the Caribbean.
has exact synonym: BLACK
has exact synonym: Black
has exact synonym: Black Populations
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Black Central American
type: Class
subclass of: Race
definition: Denotes a person of African ancestral origins whose family settled in Central America.
imported from: ncit.owl
code: C128991
Semantic_Type: Population Group
Preferred_Name: Black Central American
NCI_META_CUI: CL512097
ALT_DEFINITION: A person having origins in the original peoples of sub-Saharan Africa and Central America.
has exact synonym: BLACK CENTRAL AMERICAN
has exact synonym: Black Central American
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Black South American
type: Class
subclass of: Race
definition: Denotes a person of African ancestral origins whose family settled in South America.
imported from: ncit.owl
code: C128992
Semantic_Type: Population Group
Preferred_Name: Black South American
NCI_META_CUI: CL512098
ALT_DEFINITION: A person having origins in the original peoples of sub-Saharan Africa and South America.
has exact synonym: BLACK SOUTH AMERICAN
has exact synonym: Black South American
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

White Central American
type: Class
subclass of: White
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa and Central America.
imported from: ncit.owl
code: C128993
Semantic_Type: Population Group
Preferred_Name: White Central American
NCI_META_CUI: CL512246
ALT_DEFINITION: A person having origins in the original peoples of Europe, the Middle East, or North Africa, and Central America.
has exact synonym: WHITE CENTRAL AMERICAN
has exact synonym: White Central American
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

White South American
type: Class
subclass of: White
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa and South America.
imported from: ncit.owl
code: C128994
Semantic_Type: Population Group
Preferred_Name: White South American
NCI_META_CUI: CL512247
ALT_DEFINITION: A person having origins in the original peoples of Europe, the Middle East, or North Africa, and South America.
has exact synonym: WHITE SOUTH AMERICAN
has exact synonym: White South American
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Right Ventricular Systolic Pressure
type: Class
subclass of: Systolic Blood Pressure
definition: The maximum pressure exerted into the systemic arterial circulation during the contraction of the right ventricle of the heart.
imported from: ncit.owl
code: C129953
Semantic_Type: Quantitative Concept
Preferred_Name: Right Ventricular Systolic Pressure
UMLS_CUI: C0456181
has exact synonym: RVSP
has exact synonym: Right Ventricular Systolic Pressure

Pulmonary Artery Pressure
type: Class
subclass of: Blood Pressure
definition: Blood pressure in the pulmonary artery.
imported from: ncit.owl
code: C129958
Semantic_Type: Clinical Attribute
Preferred_Name: Pulmonary Artery Pressure
UMLS_CUI: C0428642
has exact synonym: PAP
has exact synonym: Pulmonary Artery Pressure

Left Atrial Pressure
type: Class
subclass of: Blood Pressure
definition: Blood pressure within the left atrium. It is commonly measured indirectly by a pulmonary capillary wedge pressure.
imported from: ncit.owl
code: C129959
Semantic_Type: Clinical Attribute
Preferred_Name: Left Atrial Pressure
UMLS_CUI: C0456170
has exact synonym: LAP
has exact synonym: Left Atrial Pressure
has exact synonym: PLA

Estimated Mean Atrial Pressure
type: Class
subclass of: Blood Pressure
definition: The estimated arithmetic average of atrial pressure.
imported from: ncit.owl
code: C130056
Semantic_Type: Quantitative Concept
Preferred_Name: Estimated Mean Atrial Pressure
NCI_META_CUI: CL514049
has exact synonym: Estimated Mean Atrial Pressure

Estimated Body Weight
type: Class
subclass of: Body Weight
definition: An approximate determination of the weight of a body.
imported from: ncit.owl
code: C132482
Semantic_Type: Conceptual Entity
Preferred_Name: Estimated Body Weight
NCI_META_CUI: CL521346
Contributing_Source: CDISC
ALT_DEFINITION: An approximate determination of the weight of the subject.
has exact synonym: EWEIGHT
has exact synonym: Estimated Body Weight
has exact synonym: Estimated Weight
in subset: NCIT C61410
in subset: NCIT C66741
in subset: NCIT C66830
in subset: NCIT C67153

Age at Death
type: Class
subclass of: Age
definition: The age at which death occurred.
imported from: ncit.owl
code: C135383
Semantic_Type: Organism Attribute
Preferred_Name: Age at Death
UMLS_CUI: C1546180
Contributing_Source: CDISC
ALT_DEFINITION: The age at which death occurred. (NCI)
has exact synonym: AGEDTH
has exact synonym: Age at Death
in subset: NCIT C116107
in subset: NCIT C116108
in subset: NCIT C61410
in subset: NCIT C66830

Body Mass Index Finding
type: Class
subclass of: physical examination finding
definition: The result of a body mass index measurement.
imported from: ncit.owl
code: C138901
Semantic_Type: Finding
Preferred_Name: Body Mass Index Finding
has exact synonym: BMI
has exact synonym: Body Mass Index
has exact synonym: Body Mass Index Finding

Body Mass Index Less Than 19
type: Class
subclass of: Body Mass Index Finding
definition: Indicates a body mass index measurement less than 19.
imported from: ncit.owl
code: C138932
Semantic_Type: Finding
Preferred_Name: Body Mass Index Less Than 19
has exact synonym: BMI < 19
has exact synonym: Body Mass Index Less Than 19
in subset: NCIT C138906

Body Mass Index 19 to Less Than 21
type: Class
subclass of: Body Mass Index Finding
definition: Indicates a body mass index measurement greater than or equal to 19 but below 21.
imported from: ncit.owl
code: C138933
Semantic_Type: Finding
Preferred_Name: Body Mass Index 19 to Less Than 21
has exact synonym: BMI 19 to < 21
has exact synonym: Body Mass Index 19 to Less Than 21
in subset: NCIT C138906

Body Mass Index 21 to Less Than 23
type: Class
subclass of: Body Mass Index Finding
definition: Indicates a body mass index measurement greater than or equal to 21 but below 23.
imported from: ncit.owl
code: C138934
Semantic_Type: Finding
Preferred_Name: Body Mass Index 21 to Less Than 23
has exact synonym: BMI 21 to < 23
has exact synonym: Body Mass Index 21 to Less Than 23
in subset: NCIT C138906

Body Mass Index Greater Than or Equal to 23
type: Class
subclass of: Body Mass Index Finding
definition: Indicates a body mass index measurement greater than or equal to 23.
imported from: ncit.owl
code: C138935
Semantic_Type: Finding
Preferred_Name: Body Mass Index Greater Than or Equal to 23
has exact synonym: BMI > 23
has exact synonym: Body Mass Index Greater Than or Equal to 23
in subset: NCIT C138906

Age Greater than 85 Years
type: Class
subclass of: Age
definition: An indication that an individual's age is or was greater than 85 years.
imported from: ncit.owl
code: C138936
Semantic_Type: Organism Attribute
Preferred_Name: Age Greater than 85 Years
has exact synonym: Age > 85
has exact synonym: Age Greater than 85 Years
in subset: NCIT C138906

Age Between 80 and 85 Years
type: Class
subclass of: Age
definition: An indication that an individual's age is or was between 80 and 85 years.
imported from: ncit.owl
code: C138937
Semantic_Type: Organism Attribute
Preferred_Name: Age Between 80 and 85 Years
has exact synonym: Age 80-85
has exact synonym: Age Between 80 and 85 Years
in subset: NCIT C138906

Age Less than 80 Years
type: Class
subclass of: Age
definition: An indication that an individual's age is or less than 80 years.
imported from: ncit.owl
code: C138938
Semantic_Type: Organism Attribute
Preferred_Name: Age Less than 80 Years
has exact synonym: Age < 80
has exact synonym: Age Less than 80 Years
in subset: NCIT C138906

Estimated Systolic Blood Pressure
type: Class
subclass of: Systolic Blood Pressure
definition: A quantitative estimate of the pressure in a given cardiovascular structure during ventricular systole.
imported from: ncit.owl
code: C139031
Semantic_Type: Quantitative Concept
Preferred_Name: Estimated Systolic Blood Pressure
Contributing_Source: CDISC
ALT_DEFINITION: A quantitative estimate of the pressure in a given cardiovascular structure during ventricular systole.
has exact synonym: Estimated Systolic Blood Pressure
has exact synonym: SYSPRS_E
has exact synonym: Systolic Pressure, Estimated
in subset: NCIT C101846
in subset: NCIT C101847
in subset: NCIT C61410
in subset: NCIT C66830

Age at Full-Time Use
type: Class
subclass of: Age
definition: The age at which the full-time use of an entity occurred.
imported from: ncit.owl
code: C139175
Semantic_Type: Organism Attribute
Preferred_Name: Age at Full-Time Use
Contributing_Source: CDISC
ALT_DEFINITION: The age at which the full-time use of a pre-specified object first occurred.
has exact synonym: AGEFTUSE
has exact synonym: Age at Full-Time Use
in subset: NCIT C139018
in subset: NCIT C139019
in subset: NCIT C61410
in subset: NCIT C66830

Asian American
type: Class
subclass of: Race
definition: Denotes a person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, and who was either born in the United States or who was naturalized as a citizen of the United States.
imported from: ncit.owl
code: C16310
Semantic_Type: Population Group
Preferred_Name: Asian American
UMLS_CUI: C0003988
ALT_DEFINITION: A person having origins in the original peoples of Asia and the United States.
Legacy_Concept_Name: Asian_American
has exact synonym: ASIAN AMERICAN
has exact synonym: Asian American
has exact synonym: Asian Americans
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Black or African American
type: Class
subclass of: Race
definition: A person having origins in any of the Black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American". (OMB)
imported from: ncit.owl
code: C16352
Semantic_Type: Population Group
Preferred_Name: Black or African American
UMLS_CUI: C0085756
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American." (FDA)
Legacy_Concept_Name: African_American
has exact synonym: BLACK OR AFRICAN AMERICAN
has exact synonym: Black or African American
in subset: NCIT C107675
in subset: NCIT C128689
in subset: NCIT C54452
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C74457
in subset: NCIT C77527

Body Mass Index
type: Class
subclass of: Personal Attribute
definition: A general indicator of the body fat an individual is carrying based upon the ratio of weight to height.
imported from: ncit.owl
code: C16358
Semantic_Type: Clinical Attribute
Preferred_Name: Body Mass Index
UMLS_CUI: C1305855
Contributing_Source: CDISC
Contributing_Source: NCPDP
ALT_DEFINITION: A general indicator of the body fat an individual is carrying based upon the ratio of weight to height. (NCI)
ALT_DEFINITION: A measure that relates body weight to height. BMI is sometimes used to measure total body fat and whether a person is a healthy weight. Excess body fat is linked to an increased risk of some diseases including heart disease and some cancers.
Legacy_Concept_Name: Body_Mass_Index
has exact synonym: BMI
has exact synonym: Body Mass Index
has exact synonym: Quetelet Index
has exact synonym: body mass index
in subset: NCIT C61410
in subset: NCIT C66741
in subset: NCIT C66830
in subset: NCIT C67153
in subset: NCIT C77526
in subset: NCIT C89415
in subset: NCIT C91101

Ethnic Group
type: Class
subclass of: Population Group
definition: A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C16495
code: C16564
Semantic_Type: Population Group
Preferred_Name: Ethnic Group
UMLS_CUI: C0015031
Contributing_Source: CDISC
Contributing_Source: CDISC-GLOSS
Contributing_Source: NICHD
ALT_DEFINITION: Denotes social groups with a shared history, sense of identity, geography, and cultural roots.
Legacy_Concept_Name: Ethnic_Group
NICHD_Hierarchy_Term: Ethnic Group
has exact synonym: ETHNIC
has exact synonym: Ethnic Group
has exact synonym: Ethnic Origin
has exact synonym: Ethnic Origins
has exact synonym: Ethnicity
has exact synonym: ethnicity
in subset: NCIT C61410
in subset: NCIT C67497
in subset: NCIT C83187
in subset: NCIT C83188
in subset: NCIT C89506
in subset: NCIT C90259

Population Group
type: Class
subclass of: material entity
definition: A group of individuals united by a common factor (e.g., geographic location, ethnicity, disease, age, gender)
imported from: ncit.owl
code: C17005
Semantic_Type: Population Group
Preferred_Name: Population Group
UMLS_CUI: C1257890
Contributing_Source: CDISC-GLOSS
ALT_DEFINITION: Any finite or infinite collection of subjects from which a sample is drawn for a study to obtain estimates for values that would be obtained if the entire population were sampled. [AMA style Manual]
Legacy_Concept_Name: Population_Group
has exact synonym: Group
has exact synonym: Population
has exact synonym: Population Group
has exact synonym: Subpopulation
has exact synonym: population
in subset: NCIT C61410
in subset: NCIT C67497

Poverty
type: Class
subclass of: Socioeconomic Factors
definition: A subjective and comparative term describing a lack of sufficient wealth (usually understood as capital, money, material goods, or resources especially natural resources) to live what is understood in a society as a "normal" life: for instance, to be capable of raising a healthy family, and especially educating children and participating in society. A person living in this condition of poverty is said to be poor. The meaning of "sufficient" varies widely across the different political and economic areas of the world.
imported from: ncit.owl
code: C17009
Semantic_Type: Group Attribute
Preferred_Name: Poverty
UMLS_CUI: C0032854
Legacy_Concept_Name: Poverty
has exact synonym: Low Income
has exact synonym: Poor
has exact synonym: Poverty
in subset: NCIT C19752

Race
type: Class
subclass of: Population Group
definition: An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C16495
code: C17049
Semantic_Type: Population Group
Preferred_Name: Race
UMLS_CUI: C0034510
Contributing_Source: FDA
Contributing_Source: NICHD
Legacy_Concept_Name: Race
NICHD_Hierarchy_Term: Race
has exact synonym: RACE
has exact synonym: Race
has exact synonym: Racial Group
in subset: NCIT C54447
in subset: NCIT C83187
in subset: NCIT C83188
in subset: NCIT C89506
in subset: NCIT C90259

Hispanic or Latino
type: Class
subclass of: Ethnic Group
definition: A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. The term, "Spanish origin," can be used in addition to "Hispanic or Latino." (OMB)
imported from: ncit.owl
code: C17459
Semantic_Type: Population Group
Preferred_Name: Hispanic or Latino
UMLS_CUI: C0086409
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: A person of Mexican, Puerto Rican, Cuban, Central or South American or other Spanish culture or origin, regardless of race. (NCI)
Legacy_Concept_Name: Hispanic
has exact synonym: HISPANIC OR LATINO
has exact synonym: Hispanic
has exact synonym: Hispanic Populations
has exact synonym: Hispanic or Latino
has exact synonym: Hispanics or Latinos
has exact synonym: Latino Population
has exact synonym: Spanish Origin
in subset: NCIT C128690
in subset: NCIT C19752
in subset: NCIT C61410
in subset: NCIT C66790
in subset: NCIT C66830
in subset: NCIT C77527

Socioeconomic Factors
type: Class
subclass of: information content entity
definition: Characteristics of a person such as education and occupation, used to describe the person's position in stratification systems, access to services, etc.
imported from: ncit.owl
code: C17468
Semantic_Type: Qualitative Concept
Preferred_Name: Socioeconomic Factors
UMLS_CUI: C0086996
Legacy_Concept_Name: Socioeconomic_Factors
has exact synonym: Socioeconomic Factors
has exact synonym: Socioeconomic Status

Ashkenazi Jew
type: Class
subclass of: Religious Group
subclass of: Ethnic Group
definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe.
imported from: ncit.owl
code: C17950
Semantic_Type: Population Group
Preferred_Name: Ashkenazi Jew
UMLS_CUI: C0337704
ALT_DEFINITION: A person of Ashkenazi Jewish descent.
ALT_DEFINITION: One of two major ancestral groups of Jewish individuals, comprised of those whose ancestors lived in Eastern Europe (Germany, Poland, Russia). The other group is designated Sephardic Jews and includes those whose ancestors lived in North Africa, the Middle East, and Spain. Most Jews living in the United States are Ashkenazi Jews.
Legacy_Concept_Name: Ashkenazi_Jew
has exact synonym: ASHKENAZI JEW
has exact synonym: Ashkenazi Jew
has exact synonym: Ashkenazim
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Alaska Native
type: Class
subclass of: American Indian or Alaska Native
definition: Denotes a person having origins in any indigenous people of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment. The concept refers to population subgroups such as Eskimos, Aleuts, Inupiat, Yupik, Alutiiq, Egegik,and Pribilovian, Alaskan Athabascan, Tlingit, and Haida. The concept refers also to individuals who classify themselves as such.
imported from: ncit.owl
code: C18237
Semantic_Type: Population Group
Preferred_Name: Alaska Native
UMLS_CUI: C0682125
ALT_DEFINITION: The native people of Alaska.
Legacy_Concept_Name: Alaska_Native
has exact synonym: ALASKA NATIVE
has exact synonym: Alaska Indian
has exact synonym: Alaska Indians
has exact synonym: Alaska Native
has exact synonym: Alaska Natives
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Average Household Income
type: Class
subclass of: Household Income
definition: A demographic parameter indicating the average amount of earnings made by a family in a particular population or/and during a particular period of time.
imported from: ncit.owl
code: C19308
Semantic_Type: Quantitative Concept
Preferred_Name: Average Household Income
UMLS_CUI: C1510993
Legacy_Concept_Name: Average_Household_Income
has exact synonym: Average Household Income

Number of Children in Household
type: Class
subclass of: Socioeconomic Factors
definition: a demographics parameter useful for identifying socio-economic groups.
imported from: ncit.owl
code: C19309
Semantic_Type: Quantitative Concept
Preferred_Name: Number of Children in Household
UMLS_CUI: C1518468
Legacy_Concept_Name: Number_of_Children_in_Household
has exact synonym: Number of Children in Household

Personal Attribute
type: Class
subclass of: information content entity
definition: The distinguishing qualities or prominent aspects of an individual person.
imported from: ncit.owl
code: C19332
Semantic_Type: Organism Attribute
Preferred_Name: Personal Attribute
UMLS_CUI: C0681884
Legacy_Concept_Name: Personal_Attribute
has exact synonym: Personal
has exact synonym: Personal Attribute
has exact synonym: Subject Characteristics

Age at Menarche
type: Class
subclass of: Age
definition: Age of first menstruation. A risk factor for breast cancer
imported from: ncit.owl
code: C19666
Semantic_Type: Clinical Attribute
Preferred_Name: Age at Menarche
UMLS_CUI: C1314691
Contributing_Source: CDISC
ALT_DEFINITION: The age at which the first menstruation event occurred. (NCI)
Legacy_Concept_Name: Age_at_Menarche
has exact synonym: Age at Menarche
has exact synonym: MENARAGE
has exact synonym: Menarche Age
in subset: NCIT C106478
in subset: NCIT C106479
in subset: NCIT C61410
in subset: NCIT C66830

Age at First Live Birth
type: Class
subclass of: Age
definition: The age at which a woman gave birth to her first live child.
imported from: ncit.owl
code: C19667
Semantic_Type: Clinical Attribute
Preferred_Name: Age at First Live Birth
UMLS_CUI: C1510831
Legacy_Concept_Name: Age_at_First_Live_Birth
has exact synonym: Age at First Full-Term Pregnancy
has exact synonym: Age at First Live Birth

Smoking Status
type: Class
subclass of: Personal Attribute
definition: An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history.
imported from: ncit.owl
code: C19796
Semantic_Type: Organism Attribute
Preferred_Name: Smoking Status
UMLS_CUI: C1519386
Legacy_Concept_Name: Smoking_Status
has exact synonym: Current Tobacco and Nicotine Consumption Status
has exact synonym: Smoking Status
in subset: NCIT C19752

Age
type: Class
subclass of: Personal Attribute
definition: How long something has existed; elapsed time since birth.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C89335
code: C25150
Semantic_Type: Organism Attribute
Preferred_Name: Age
UMLS_CUI: C0001779
Contributing_Source: CDISC
Contributing_Source: FDA
Contributing_Source: NICHD
ALT_DEFINITION: How long something has existed; elapsed time since birth. (NCI)
ALT_DEFINITION: The time elapsed since birth.
Legacy_Concept_Name: Age
NICHD_Hierarchy_Term: Chronological Age
has exact synonym: AGE
has exact synonym: Age
has exact synonym: Aged
has exact synonym: Chronological Age
has exact synonym: Postnatal Age
has exact synonym: age
in subset: NCIT C118466
in subset: NCIT C19752
in subset: NCIT C54447
in subset: NCIT C61410
in subset: NCIT C77526
in subset: NCIT C83187
in subset: NCIT C83188
in subset: NCIT C90007
in subset: NCIT C90009
in subset: NCIT C90259

Systolic Blood Pressure
type: Class
subclass of: Blood Pressure
definition: The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart.
imported from: ncit.owl
code: C25298
Semantic_Type: Quantitative Concept
Preferred_Name: Systolic Blood Pressure
UMLS_CUI: C0871470
Contributing_Source: CDISC
Contributing_Source: NCPDP
ALT_DEFINITION: The maximum blood pressure in the systemic arterial circulation during the cardiac cycle.
Legacy_Concept_Name: Systolic_Pressure
has exact synonym: SYSBP
has exact synonym: Systolic Blood Pressure
has exact synonym: Systolic Pressure
in subset: NCIT C120532
in subset: NCIT C120533
in subset: NCIT C61410
in subset: NCIT C66741
in subset: NCIT C66830
in subset: NCIT C67153
in subset: NCIT C77526
in subset: NCIT C89415
in subset: NCIT C91101

Diastolic Blood Pressure
type: Class
subclass of: Blood Pressure
definition: The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling.
imported from: ncit.owl
code: C25299
Semantic_Type: Clinical Attribute
Preferred_Name: Diastolic Blood Pressure
UMLS_CUI: C0428883
Contributing_Source: CDISC
Contributing_Source: NCPDP
ALT_DEFINITION: The minimum blood pressure in the systemic arterial circulation during the cardiac cycle.
Legacy_Concept_Name: Diastolic_Pressure
has exact synonym: DIABP
has exact synonym: Diastolic Blood Pressure
has exact synonym: Diastolic Pressure
in subset: NCIT C120532
in subset: NCIT C120533
in subset: NCIT C61410
in subset: NCIT C66741
in subset: NCIT C66830
in subset: NCIT C67153
in subset: NCIT C77526
in subset: NCIT C89415
in subset: NCIT C91101

Height
type: Class
subclass of: Personal Attribute
definition: The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension.
imported from: ncit.owl
code: C25347
Semantic_Type: Quantitative Concept
Preferred_Name: Height
UMLS_CUI: C0489786
Contributing_Source: CDISC
Contributing_Source: FDA
Contributing_Source: NCPDP
ALT_DEFINITION: The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension. (NCI)
ALT_DEFINITION: Vertical measurement value.
Legacy_Concept_Name: Height
has exact synonym: HEIGHT
has exact synonym: Height
in subset: NCIT C106039
in subset: NCIT C61410
in subset: NCIT C66741
in subset: NCIT C66830
in subset: NCIT C67153
in subset: NCIT C77526
in subset: NCIT C89415
in subset: NCIT C91101

International Normalized Ratio
type: Class
subclass of: blood measurement
definition: A system, commonly called the INR, established by the World Health Organization (WHO) and the International Committee on Thrombosis and Hemostasis for reporting the results of blood coagulation (clotting) tests. All results are standardized using the international sensitivity index (ISI) for the particular thromboplastin reagent and instrument combination utilized to perform the test; the ratio of a patient's clotting time to the lab's mean reference value is normalized against the ISI. (from medterms.com and medicine.ucsf.edu)
imported from: ncit.owl
code: C25352
Semantic_Type: Quantitative Concept
Preferred_Name: International Normalized Ratio
NCI_META_CUI: CL448971
Legacy_Concept_Name: International_Normalized_Ratio
has exact synonym: INR
has exact synonym: International Normalized Ratio

Low Birth Weight
type: Class
subclass of: Birth Weight (NCIT)
definition: A birth weight that is less than 2500 grams.
imported from: ncit.owl
Has_NICHD_Parent: Birth Weight (NCIT)
code: C34724
Semantic_Type: Finding
Preferred_Name: Low Birth Weight
UMLS_CUI: C0024032
Contributing_Source: GAIA
Contributing_Source: NICHD
ALT_DEFINITION: Birth weight less than 2500 grams.
Legacy_Concept_Name: Low_Birth_Weight
NICHD_Hierarchy_Term: Low Birth Weight
has exact synonym: Low Birth Weight
in subset: NCIT C118466
in subset: NCIT C125481
in subset: NCIT C128701
in subset: NCIT C89506
in subset: NCIT C90259

Age-Months
type: Class
subclass of: Age
definition: The length of a person's life, stated in months since birth.
imported from: ncit.owl
code: C37907
Semantic_Type: Organism Attribute
Preferred_Name: Age-Months
UMLS_CUI: C1510828
Contributing_Source: NCPDP
Legacy_Concept_Name: Age-Months
has exact synonym: Age, in Months
has exact synonym: Age-Months
in subset: NCIT C89415
in subset: NCIT C91101

Age-Years
type: Class
subclass of: Age
definition: The length of a person's life, stated in years since birth.
imported from: ncit.owl
code: C37908
Semantic_Type: Organism Attribute
Preferred_Name: Age-Years
UMLS_CUI: C1510829
Contributing_Source: NCPDP
Legacy_Concept_Name: Age-Years
has exact synonym: Age, in Years
has exact synonym: Age-Years
in subset: NCIT C89415
in subset: NCIT C91101

Income
type: Class
subclass of: Socioeconomic Factors
definition: A gain or recurrent benefit during a period of time, usually measured in money that derives from capital or labor.
imported from: ncit.owl
code: C41150
Semantic_Type: Group Attribute
Preferred_Name: Income
UMLS_CUI: C0021162
Legacy_Concept_Name: Income
DesignNote: Income is one of the major demographic parameters used in population-based biomedical research.
has exact synonym: Income
in subset: NCIT C19752

Native Hawaiian or Other Pacific Islander
type: Class
subclass of: Race
definition: A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands. (OMB)
imported from: ncit.owl
code: C41219
Semantic_Type: Population Group
Preferred_Name: Native Hawaiian or Other Pacific Islander
UMLS_CUI: C1513907
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: Denotes a person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands. The term covers particularly people who identify themselves as part-Hawaiian, Native Hawaiian, Guamanian or Chamorro, Carolinian, Samoan, Chuu. (FDA)
Legacy_Concept_Name: Native_Hawaiian_or_Other_Pacific_Islander
has exact synonym: NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER
has exact synonym: Native Hawaiian or Other Pacific Islander
in subset: NCIT C107675
in subset: NCIT C128689
in subset: NCIT C54452
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C74457
in subset: NCIT C77527

Not Hispanic or Latino
type: Class
subclass of: Ethnic Group
definition: A person not of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race.
imported from: ncit.owl
code: C41222
Semantic_Type: Population Group
Preferred_Name: Not Hispanic or Latino
UMLS_CUI: C1518424
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: A person not of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. An arbitrary ethnic classification. (NCI)
Legacy_Concept_Name: Not_Hispanic_or_Latino
has exact synonym: NOT HISPANIC OR LATINO
has exact synonym: Non-Hispanic
has exact synonym: Non-Hispanic or Latino
has exact synonym: Not Hispanic or Latino
has exact synonym: Not Hispanic/Spanish origin
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66790
in subset: NCIT C66830
in subset: NCIT C77527

African Caribbean
type: Class
subclass of: Race
definition: Denotes a person of African ancestral origins whose family settled in the Caribbean region.
imported from: ncit.owl
code: C41226
Semantic_Type: Population Group
Preferred_Name: African Caribbean
UMLS_CUI: C0422771
ALT_DEFINITION: A person having origins in the original peoples of sub-Saharan Africa and the Caribbean.
Legacy_Concept_Name: African_Caribbean
has exact synonym: AFRICAN CARIBBEAN
has exact synonym: African Caribbean
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

American Indian or Alaska Native
type: Class
subclass of: Population Group
subclass of: Race
definition: A person having origins in any of the original peoples of North and South America (including Central America) and who maintains tribal affiliation or community attachment. (OMB)
imported from: ncit.owl
code: C41259
Semantic_Type: Population Group
Preferred_Name: American Indian or Alaska Native
UMLS_CUI: C0282204
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the original peoples of North and South America (including Central America), and who maintains tribal affiliation or community attachment. (FDA)
Legacy_Concept_Name: American_Indian_or_Alaska_Native
has exact synonym: AMERICAN INDIAN OR ALASKA NATIVE
has exact synonym: American Indian or Alaska Native
has exact synonym: First Nations
has exact synonym: Native American
has exact synonym: Native Americans
in subset: NCIT C107675
in subset: NCIT C128689
in subset: NCIT C54452
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C74457
in subset: NCIT C77527

Asian
type: Class
subclass of: Race
definition: A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. (OMB)
imported from: ncit.owl
code: C41260
Semantic_Type: Population Group
Preferred_Name: Asian
UMLS_CUI: C0078988
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent including, for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. (FDA)
Legacy_Concept_Name: Asian
has exact synonym: ASIAN
has exact synonym: Asian
has exact synonym: Asians
in subset: NCIT C107675
in subset: NCIT C128689
in subset: NCIT C54452
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C74457
in subset: NCIT C77527

White
type: Class
subclass of: Race
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa. (OMB)
imported from: ncit.owl
code: C41261
Semantic_Type: Population Group
Preferred_Name: White
UMLS_CUI: C0043157
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: Denotes a person with European, Middle Eastern, or North African ancestral origin who identifies, or is identified, as White. (FDA)
Legacy_Concept_Name: White
has exact synonym: Caucasian
has exact synonym: Caucasians
has exact synonym: Caucasoid
has exact synonym: Occidental
has exact synonym: WHITE
has exact synonym: White
has exact synonym: Whites
in subset: NCIT C107675
in subset: NCIT C128689
in subset: NCIT C54452
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C74457
in subset: NCIT C77527

Asian Indian
type: Class
subclass of: South Asian
definition: A person having origins in the original peoples of the Indian sub-continent.
imported from: ncit.owl
code: C41262
Semantic_Type: Population Group
Preferred_Name: Asian Indian
UMLS_CUI: C1524069
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the original peoples of the Indian subcontinent.
Legacy_Concept_Name: Asian_Indian
DesignNote: The concept is close to the term South Asian but several major South Asian populations such as Pakistani and Bangladeshi may not identify with it.
has exact synonym: ASIAN INDIAN
has exact synonym: Asian Indian
has exact synonym: Asian Indians
has exact synonym: Indian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

South Asian
type: Class
subclass of: Asian
definition: Denotes a person whose ancestry is in the countries of the Indian sub-continent, including India, Pakistan, Bangladesh, and Sri Lanka.
imported from: ncit.owl
code: C41263
Semantic_Type: Population Group
Preferred_Name: South Asian
UMLS_CUI: C1519427
Legacy_Concept_Name: South_Asian
has exact synonym: South Asian
has exact synonym: South Asians

African
type: Class
subclass of: Race
definition: Denotes a person with African ancestral origins who self identifies, or is identified, as African. The concept does not refer to those of other ancestry, for example, European and South Asian. In practice, the term mainly refers to people originated from forty-eight sub-Saharan Africa nations; and excludes individuals from North Africa countries, e.g. such as Algeria, Morocco, Egypt, Tunisia with Arab and Berber ethnicity.
imported from: ncit.owl
code: C42331
Semantic_Type: Population Group
Preferred_Name: African
UMLS_CUI: C0027567
ALT_DEFINITION: A person having origins in any of the original peoples of sub-Saharan Africa.
Legacy_Concept_Name: African
has exact synonym: AFRICAN
has exact synonym: African
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Unit by Category
type: Class
subclass of: information content entity
imported from: ncit.owl
code: C42568
Semantic_Type: Classification
Preferred_Name: Unit by Category
UMLS_CUI: C1710551
Concept_Status: Header_Concept
Legacy_Concept_Name: Unit_by_Category
has exact synonym: Unit by Category

Aleutian
type: Class
subclass of: Unangan Aleut
definition: Aleutian - a person having origins from the Aleut indigenous group of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment.
imported from: ncit.owl
code: C43389
Semantic_Type: Population Group
Preferred_Name: Aleutian
UMLS_CUI: C1553304
Legacy_Concept_Name: Aleutian
has exact synonym: Aleutian

Eskimo
type: Class
subclass of: Race
definition: The native people inhabiting the Arctic of northern Canada, Greenland, Alaska, or eastern Siberia. The two main groups referred to as Eskimo are the Yupik and Inuit. A third group, the Aleut, is related. In Canada and Greenland, the term Eskimo has fallen out of favor, as it is considered pejorative by the natives and has been replaced by the term Inuit.
imported from: ncit.owl
code: C43390
Semantic_Type: Population Group
Preferred_Name: Eskimo
UMLS_CUI: C0014845
Legacy_Concept_Name: Eskimo
has exact synonym: Eskimo
has exact synonym: Inuit

Chinese
type: Class
subclass of: Asian
definition: A person having origins in any of the original peoples of China.
imported from: ncit.owl
code: C43391
Semantic_Type: Population Group
Preferred_Name: Chinese
UMLS_CUI: C0152035
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the original peoples of China.
Legacy_Concept_Name: Chinese
has exact synonym: CHINESE
has exact synonym: Chinese
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Japanese
type: Class
subclass of: Asian
definition: A person having origins in any of the original peoples of Japan..
imported from: ncit.owl
code: C43392
Semantic_Type: Population Group
Preferred_Name: Japanese
UMLS_CUI: C1556094
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the original peoples of Japan.
Legacy_Concept_Name: Japanese
has exact synonym: JAPANESE
has exact synonym: Japanese
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Filipino
type: Class
subclass of: Asian
definition: A person having origins in any of the original peoples of the Philippine Islands.
imported from: ncit.owl
code: C43393
Semantic_Type: Population Group
Preferred_Name: Filipino
UMLS_CUI: C1556093
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the original peoples of the Philippines.
Legacy_Concept_Name: Filipino
has exact synonym: FILIPINO
has exact synonym: Filipino
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Native Hawaiian
type: Class
subclass of: Polynesian
definition: A person having origins in any of the original peoples of Hawaii.
imported from: ncit.owl
code: C43394
Semantic_Type: Population Group
Preferred_Name: Native Hawaiian
UMLS_CUI: C0337920
Contributing_Source: FDA
Legacy_Concept_Name: Hawaiian
has exact synonym: Hawaiian
has exact synonym: Native Hawaiian

Korean
type: Class
subclass of: Asian
definition: A person having origins in any of the original peoples of Korea.
imported from: ncit.owl
code: C43395
Semantic_Type: Population Group
Preferred_Name: Korean
UMLS_CUI: C1556095
ALT_DEFINITION: A person having origins in any of the original peoples of North and South Korea.
Legacy_Concept_Name: Korean
has exact synonym: KOREAN
has exact synonym: Korean
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Vietnamese
type: Class
subclass of: Asian
definition: A person having origins in any of the original peoples of Viet Nam.
imported from: ncit.owl
code: C43396
Semantic_Type: Population Group
Preferred_Name: Vietnamese
UMLS_CUI: C1561452
Contributing_Source: FDA
ALT_DEFINITION: A person having origins in any of the original peoples of Viet Nam.
Legacy_Concept_Name: Vietnamese
has exact synonym: VIETNAMESE
has exact synonym: Vietnamese
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Laotian
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Laos, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43397
Semantic_Type: Population Group
Preferred_Name: Laotian
UMLS_CUI: C1553325
ALT_DEFINITION: A person having origins in any of the original peoples of Laos.
Legacy_Concept_Name: Laotian
has exact synonym: LAOTIAN
has exact synonym: Laotian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Hmong
type: Class
subclass of: Asian
definition: Denotes a person having origins in any of the original Hmong people originating in China around the Yellow River or Hoang Ho.
imported from: ncit.owl
code: C43398
Semantic_Type: Population Group
Preferred_Name: Hmong
UMLS_CUI: C1553324
ALT_DEFINITION: The native people originating in China around the Yellow River or Hoang Ho.
Legacy_Concept_Name: Hmong
DesignNote: Early in the 19th century, the Hmong migrated to French Indochina, which comprised Vietnam, Cambodia and Laos. In 1947, Hmong officially became citizens of Loas. Later a number of Hmong emigrated to Thailand and the United States.
has exact synonym: HMONG
has exact synonym: Hmong
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Cambodian
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Cambodia (formerly Kampuchea), a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43399
Semantic_Type: Population Group
Preferred_Name: Cambodian
UMLS_CUI: C1553323
ALT_DEFINITION: A person having origins in any of the original peoples of Cambodia (formerly Kampuchea).
Legacy_Concept_Name: Kampuchean
has exact synonym: CAMBODIAN
has exact synonym: Cambodian
has exact synonym: Kampuchean
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Thai
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Thailand, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43400
Semantic_Type: Population Group
Preferred_Name: Thai
UMLS_CUI: C0337910
ALT_DEFINITION: A person having origins in any of the original peoples of Thailand.
Legacy_Concept_Name: Thai
has exact synonym: THAI
has exact synonym: Thai
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Micronesian
type: Class
subclass of: Native Hawaiian or Other Pacific Islander
definition: Denotes a person from any of the islands in the western pacific encompassing the area from the Philippines in the west, Indonesia to the south west, Papua New Guinea and Melanesia to the south, and Polynesia to the south-east and east.
imported from: ncit.owl
code: C43402
Semantic_Type: Population Group
Preferred_Name: Micronesian
UMLS_CUI: C1556099
ALT_DEFINITION: A person having origins in any of the original peoples of Micronesia.
Legacy_Concept_Name: Micronesian
has exact synonym: MICRONESIAN
has exact synonym: Micronesian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Chamorran
type: Class
subclass of: Guamanian or Chamorro
definition: Denotes any of the indigenous Chamorro people of Guam and the Mariana Islands or persons of that ancestry.
imported from: ncit.owl
code: C43403
Semantic_Type: Population Group
Preferred_Name: Chamorran
UMLS_CUI: C1553343
Legacy_Concept_Name: Chamorran
has exact synonym: Chamorran
has exact synonym: Chamorro

Guamanian
type: Class
subclass of: Guamanian or Chamorro
definition: Denotes the inhabitants of Guam, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43404
Semantic_Type: Population Group
Preferred_Name: Guamanian
UMLS_CUI: C0920541
Legacy_Concept_Name: Guamanian
has exact synonym: Guamanian

Polynesian
type: Class
subclass of: Native Hawaiian or Other Pacific Islander
definition: Denotes a person from any of the over 1,000 islands in the central and southern Pacific Ocean bounded by a triangle with its three corners at Hawaii, New Zealand, and Easter Island or a person of that ancestry.
imported from: ncit.owl
code: C43405
Semantic_Type: Population Group
Preferred_Name: Polynesian
UMLS_CUI: C0240790
ALT_DEFINITION: A person having origins in any of the original peoples of Polynesia.
Legacy_Concept_Name: Polynesian
has exact synonym: POLYNESIAN
has exact synonym: Polynesian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Tahitian
type: Class
subclass of: Polynesian
definition: Denotes the inhabitants of Tahiti, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43406
Semantic_Type: Population Group
Preferred_Name: Tahitian
UMLS_CUI: C0241329
Legacy_Concept_Name: Tahitian
has exact synonym: Tahitian

Samoan
type: Class
subclass of: Polynesian
definition: A person having origins in any of the original peoples of Samoa.
imported from: ncit.owl
code: C43407
Semantic_Type: Population Group
Preferred_Name: Samoan
UMLS_CUI: C1556103
Contributing_Source: FDA
Legacy_Concept_Name: Samoan
has exact synonym: Samoan

Tongan
type: Class
subclass of: Polynesian
definition: Denotes the inhabitants of Tonga, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43408
Semantic_Type: Population Group
Preferred_Name: Tongan
UMLS_CUI: C0337933
Legacy_Concept_Name: Tongan
has exact synonym: Tongan

Melanesian
type: Class
subclass of: Native Hawaiian or Other Pacific Islander
definition: Denotes a person from any of the islands in the region extending from the west Pacific to the Arafura Sea, north and north-east of Australia. or of that ancestry.
imported from: ncit.owl
code: C43409
Semantic_Type: Population Group
Preferred_Name: Melanesian
UMLS_CUI: C0337924
ALT_DEFINITION: A person having origins in any of the original peoples of Melanesia.
Legacy_Concept_Name: Melanesian
has exact synonym: MELANESIAN
has exact synonym: Melanesian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Fiji Islander
type: Class
subclass of: Melanesian
definition: Denotes the inhabitants of Fiji, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43410
Semantic_Type: Population Group
Preferred_Name: Fiji Islander
UMLS_CUI: C1556097
Legacy_Concept_Name: Fiji_Islander
has exact synonym: Fiji Islander
has exact synonym: Fijian

Papua New Guinean
type: Class
subclass of: Melanesian
definition: Denotes the inhabitants of Papua New Guinea, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43411
Semantic_Type: Population Group
Preferred_Name: Papua New Guinean
UMLS_CUI: C1553350
Legacy_Concept_Name: New_Guinean
has exact synonym: New Guinean
has exact synonym: Papua New Guinean

Pakistani
type: Class
subclass of: South Asian
definition: Primarily refers to a person having origins in the original peoples of the Indian sub-continent, a subset of which formed Pakistan. The term also refers to a person from Pakistan, whether or not ancestors were from India.
imported from: ncit.owl
code: C43427
Semantic_Type: Population Group
Preferred_Name: Pakistani
UMLS_CUI: C0240620
ALT_DEFINITION: A person having origins in any of the original peoples of Pakistan.
Legacy_Concept_Name: Pakistani
has exact synonym: PAKISTANI
has exact synonym: Pakistani
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Alaska Indian
type: Class
subclass of: Alaska Native
imported from: ncit.owl
code: C43650
Semantic_Type: Population Group
Preferred_Name: Alaska Indian
NCI_META_CUI: CL333681
Legacy_Concept_Name: Alaska_Indian
has exact synonym: Alaska Indian

Bangladeshi
type: Class
subclass of: South Asian
definition: Denotes the inhabitants of Bangladesh, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43671
Semantic_Type: Population Group
Preferred_Name: Bangladeshi
UMLS_CUI: C1556107
ALT_DEFINITION: A person having origins in any of the original peoples of Bangladesh.
Legacy_Concept_Name: Bangladeshi
has exact synonym: BANGLADESHI
has exact synonym: Bangladeshi
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Sri Lankan
type: Class
subclass of: South Asian
definition: Denotes the inhabitants of Sri Lanka, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43672
Semantic_Type: Population Group
Preferred_Name: Sri Lankan
UMLS_CUI: C1553327
ALT_DEFINITION: A person having origins in any of the original peoples of Sri Lanka.
Legacy_Concept_Name: Sri_Lankan
has exact synonym: SRI LANKAN
has exact synonym: Sri Lankan
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Bhutanese
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Bhutan, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43673
Semantic_Type: Population Group
Preferred_Name: Bhutanese
UMLS_CUI: C0337894
Contributing_Source: CDISC
ALT_DEFINITION: A person having origins in any of the original peoples of Bhutan.
Legacy_Concept_Name: Bhutanese
has exact synonym: BHUTANESE
has exact synonym: Bhutanese
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Burmese
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Myanmar (formerly Burma), a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43674
Semantic_Type: Population Group
Preferred_Name: Burmese
UMLS_CUI: C1553322
ALT_DEFINITION: A person having origins in any of the original peoples of Myanmar (formerly Burma).
Legacy_Concept_Name: Burmese
has exact synonym: BURMESE
has exact synonym: Burmese
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Taiwanese
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Taiwan, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43675
Semantic_Type: Population Group
Preferred_Name: Taiwanese
UMLS_CUI: C1556096
ALT_DEFINITION: A person having origins in any of the original peoples of Taiwan.
Legacy_Concept_Name: Taiwanese
has exact synonym: TAIWANESE
has exact synonym: Taiwanese
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Indonesian
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Indonesia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43715
Semantic_Type: Population Group
Preferred_Name: Indonesian
UMLS_CUI: C0337900
ALT_DEFINITION: A person having origins in any of the original peoples of Indonesia.
Legacy_Concept_Name: Indonesian
has exact synonym: INDONESIAN
has exact synonym: Indonesian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Malaysian
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Malaysia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43716
Semantic_Type: Population Group
Preferred_Name: Malaysian
UMLS_CUI: C0240293
ALT_DEFINITION: A person having origins in any of the original peoples of Malaysia.
Legacy_Concept_Name: Malaysian
has exact synonym: MALAYSIAN
has exact synonym: Malaysian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Okinawan
type: Class
subclass of: Asian
definition: Denotes the inhabitants of the japanese island of Okinawa, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43717
Semantic_Type: Population Group
Preferred_Name: Okinawan
UMLS_CUI: C1553326
ALT_DEFINITION: A person having origins in any of the original peoples of Okinawa.
Legacy_Concept_Name: Okinawan
has exact synonym: OKINAWAN
has exact synonym: Okinawan
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Iwo Jiman
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Iwo Jima, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43718
Semantic_Type: Population Group
Preferred_Name: Iwo Jiman
UMLS_CUI: C1553328
ALT_DEFINITION: A person having origins in any of the original peoples of Iwo Jima.
Legacy_Concept_Name: Iwo_Jiman
has exact synonym: IWO JIMAN
has exact synonym: Iwo Jiman
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Maldivian
type: Class
subclass of: Asian
definition: Denotes the inhabitants of the Maldives, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43719
Semantic_Type: Population Group
Preferred_Name: Maldivian
UMLS_CUI: C1553329
ALT_DEFINITION: A person having origins in any of the original peoples of the Maldives.
Legacy_Concept_Name: Maldivian
has exact synonym: MALDIVIAN
has exact synonym: Maldivian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Nepalese
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Nepal, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43720
Semantic_Type: Population Group
Preferred_Name: Nepalese
UMLS_CUI: C1553330
ALT_DEFINITION: A person having origins in any of the original peoples of Nepal.
Legacy_Concept_Name: Nepalese
has exact synonym: NEPALESE
has exact synonym: Nepalese
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Singaporean
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Singapore, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43721
Semantic_Type: Population Group
Preferred_Name: Singaporean
UMLS_CUI: C1553331
ALT_DEFINITION: A person having origins in any of the original peoples of Singapore.
Legacy_Concept_Name: Singaporean
has exact synonym: SINGAPOREAN
has exact synonym: Singaporean
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Malagasy
type: Class
subclass of: African
definition: Denotes the inhabitants of Madagascar, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43722
Semantic_Type: Population Group
Preferred_Name: Malagasy
UMLS_CUI: C1553332
ALT_DEFINITION: A person having origins in any of the original peoples of Madagascar.
Legacy_Concept_Name: Madagascar_Race
has exact synonym: MALAGASY
has exact synonym: Madagascar
has exact synonym: Malagasy
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Barbadian
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of Barbados, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43823
Semantic_Type: Population Group
Preferred_Name: Barbadian
UMLS_CUI: C1553337
ALT_DEFINITION: A person having origins in any of the original peoples of Barbados.
Legacy_Concept_Name: Barbadian
has exact synonym: BARBADIAN
has exact synonym: Barbadian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Dominica Islander
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of Dominica, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43824
Semantic_Type: Population Group
Preferred_Name: Dominica Islander
UMLS_CUI: C1553338
ALT_DEFINITION: A person having origins in any of the original peoples of Dominica.
Legacy_Concept_Name: Dominican
has exact synonym: DOMINICA ISLANDER
has exact synonym: Dominica Islander
has exact synonym: Dominican
in subset: NCIT C128689
in subset: NCIT C19752
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Haitian
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of Haiti, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43825
Semantic_Type: Population Group
Preferred_Name: Haitian
UMLS_CUI: C0239806
ALT_DEFINITION: A person having origins in any of the original peoples of Haiti.
Legacy_Concept_Name: Haitian
has exact synonym: HAITIAN
has exact synonym: Haitian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Jamaican
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of Jamaica, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43826
Semantic_Type: Population Group
Preferred_Name: Jamaican
UMLS_CUI: C0240072
ALT_DEFINITION: A person having origins in any of the original peoples of Jamaica.
Legacy_Concept_Name: Jamaican
has exact synonym: JAMAICAN
has exact synonym: Jamaican
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Tobagoan
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of Tobago, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43827
Semantic_Type: Population Group
Preferred_Name: Tobagoan
UMLS_CUI: C1553339
ALT_DEFINITION: A person having origins in any of the original peoples of Tobago.
Legacy_Concept_Name: Tobagoan
has exact synonym: TOBAGOAN
has exact synonym: Tobagoan
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Trinidadian
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of Trinidad, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43828
Semantic_Type: Population Group
Preferred_Name: Trinidadian
UMLS_CUI: C1553340
ALT_DEFINITION: A person having origins in any of the original peoples of Trinidad.
Legacy_Concept_Name: Trinidadian
has exact synonym: TRINIDADIAN
has exact synonym: Trinidadian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

West Indian
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of the West Indies, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43829
Semantic_Type: Population Group
Preferred_Name: West Indian
UMLS_CUI: C0425373
ALT_DEFINITION: A person having origins in any of the original peoples of the West Indies.
Legacy_Concept_Name: West_Indian
has exact synonym: WEST INDIAN
has exact synonym: West Indian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Botswanan
type: Class
subclass of: African
definition: Denotes the inhabitants of Botswana, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43830
Semantic_Type: Population Group
Preferred_Name: Botswanan
UMLS_CUI: C1553333
ALT_DEFINITION: A person having origins in any of the original peoples of Botswana.
Legacy_Concept_Name: Botswanan
has exact synonym: BOTSWANAN
has exact synonym: Botswanan
has exact synonym: Motswana
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Ethiopian
type: Class
subclass of: African
definition: Denotes the inhabitants of Ethiopia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43831
Semantic_Type: Population Group
Preferred_Name: Ethiopian
UMLS_CUI: C0239304
ALT_DEFINITION: A person having origins in any of the original peoples of Ethiopia.
Legacy_Concept_Name: Ethiopian
has exact synonym: ETHIOPIAN
has exact synonym: Ethiopian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Liberian
type: Class
subclass of: African
definition: Denotes the inhabitants of Liberia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43832
Semantic_Type: Population Group
Preferred_Name: Liberian
UMLS_CUI: C1556088
ALT_DEFINITION: A person having origins in any of the original peoples of Liberia.
Legacy_Concept_Name: Liberian
has exact synonym: LIBERIAN
has exact synonym: Liberian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Namibian
type: Class
subclass of: African
definition: Denotes the inhabitants of Namibia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43833
Semantic_Type: Population Group
Preferred_Name: Namibian
UMLS_CUI: C1553334
ALT_DEFINITION: A person having origins in any of the original peoples of Namibia.
Legacy_Concept_Name: Namibian
has exact synonym: NAMIBIAN
has exact synonym: Namibian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Nigerian
type: Class
subclass of: African
definition: Denotes the inhabitants of Nigeria, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43834
Semantic_Type: Population Group
Preferred_Name: Nigerian
UMLS_CUI: C1556089
ALT_DEFINITION: A person having origins in any of the original peoples of Nigeria.
Legacy_Concept_Name: Nigerian
has exact synonym: NIGERIAN
has exact synonym: Nigerian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Zairean
type: Class
subclass of: African
definition: Denotes the inhabitants of the Democratic Republic of the Congo (formerly Zaire), a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43835
Semantic_Type: Population Group
Preferred_Name: Zairean
UMLS_CUI: C1553335
ALT_DEFINITION: A person having origins in any of the original peoples of Zaire.
Legacy_Concept_Name: Zairean
has exact synonym: ZAIREAN
has exact synonym: Zairean
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Tokelauan
type: Class
subclass of: Polynesian
definition: Denotes the inhabitants of Tokelau, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43836
Semantic_Type: Population Group
Preferred_Name: Tokelauan
UMLS_CUI: C0438967
Legacy_Concept_Name: Tokelauan
has exact synonym: Tokelauan

Guamanian or Chamorro
type: Class
subclass of: Micronesian
definition: A person having origins in any of the original peoples of Guam or the Mariana Islands.
imported from: ncit.owl
code: C43837
Semantic_Type: Population Group
Preferred_Name: Guamanian or Chamorro
UMLS_CUI: C1553342
Contributing_Source: FDA
Legacy_Concept_Name: Guamanian_or_Chamorro
has exact synonym: Guamanian or Chamorro

Mariana Islander
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the Northern Mariana Islands, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43838
Semantic_Type: Population Group
Preferred_Name: Mariana Islander
UMLS_CUI: C1553344
Legacy_Concept_Name: Mariana_Islander
has exact synonym: Mariana Islander

Marshallese
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the Marshall Islands, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43839
Semantic_Type: Population Group
Preferred_Name: Marshallese
UMLS_CUI: C1556098
Legacy_Concept_Name: Marshallese
has exact synonym: Marshallese

Palauan
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of Palau, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43840
Semantic_Type: Population Group
Preferred_Name: Palauan
UMLS_CUI: C0337928
Legacy_Concept_Name: Palauan
has exact synonym: Palauan

Carolinian
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the Caroline Islands, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43841
Semantic_Type: Population Group
Preferred_Name: Carolinian
UMLS_CUI: C1553345
Legacy_Concept_Name: Carolinian
has exact synonym: Carolinian

Kosraean
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the island of Kosrae, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43842
Semantic_Type: Population Group
Preferred_Name: Kosraean
UMLS_CUI: C1553346
Legacy_Concept_Name: Kosraean
has exact synonym: Kosraean

Pohnpeian
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the island of Pohnpei, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43843
Semantic_Type: Population Group
Preferred_Name: Pohnpeian
UMLS_CUI: C1553347
Legacy_Concept_Name: Pohnpeian
has exact synonym: Pohnpeian

Saipanese
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the Saipan Islands, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43844
Semantic_Type: Population Group
Preferred_Name: Saipanese
UMLS_CUI: C1556102
Legacy_Concept_Name: Saipanese
has exact synonym: Saipanese

Kiribati
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of Kiribati, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43845
Semantic_Type: Population Group
Preferred_Name: Kiribati
UMLS_CUI: C1553348
Legacy_Concept_Name: Kiribati_Race
has exact synonym: Kiribati

Chuukese
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the island of Chuuk, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43846
Semantic_Type: Population Group
Preferred_Name: Chuukese
UMLS_CUI: C1553349
Legacy_Concept_Name: Chuukese
has exact synonym: Chuukese

Yapese
type: Class
subclass of: Micronesian
definition: Denotes the inhabitants of the island of Yap, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43847
Semantic_Type: Population Group
Preferred_Name: Yapese
UMLS_CUI: C1556105
Legacy_Concept_Name: Yapese
has exact synonym: Yapese

Solomon Islander
type: Class
subclass of: Melanesian
definition: Denotes the inhabitants of the Solomon Islands, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43849
Semantic_Type: Population Group
Preferred_Name: Solomon Islander
UMLS_CUI: C0337932
Legacy_Concept_Name: Solomon_Islander
has exact synonym: Solomon Islander

New Hebrides
type: Class
subclass of: Melanesian
definition: Denotes the inhabitants of the islands of Vanuatu, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43850
Semantic_Type: Population Group
Preferred_Name: New Hebrides
UMLS_CUI: C1571857
Legacy_Concept_Name: New_Hebrides
has exact synonym: New Hebrides

European
type: Class
subclass of: White
definition: Denotes the inhabitants of any of the countries of Europe, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43851
Semantic_Type: Population Group
Preferred_Name: European
UMLS_CUI: C1535514
ALT_DEFINITION: A person having origins in any of the original peoples of Europe.
Legacy_Concept_Name: European
has exact synonym: EUROPEAN
has exact synonym: European
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Armenian
type: Class
subclass of: European
definition: Denotes the inhabitants of Armenia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43852
Semantic_Type: Population Group
Preferred_Name: Armenian
UMLS_CUI: C0337794
Legacy_Concept_Name: Armenian
has exact synonym: Armenian

English
type: Class
subclass of: European
definition: Denotes the inhabitants of England, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43853
Semantic_Type: Population Group
Preferred_Name: English
UMLS_CUI: C1556083
Legacy_Concept_Name: English
has exact synonym: English

French
type: Class
subclass of: European
definition: Denotes the inhabitants of France, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43854
Semantic_Type: Population Group
Preferred_Name: French
UMLS_CUI: C1556084
Legacy_Concept_Name: French
has exact synonym: French

German
type: Class
subclass of: European
definition: Denotes the inhabitants of Germany, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43855
Semantic_Type: Population Group
Preferred_Name: German
UMLS_CUI: C1556085
Legacy_Concept_Name: German
has exact synonym: German

Irish
type: Class
subclass of: European
definition: Denotes the inhabitants of Ireland, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43856
Semantic_Type: Population Group
Preferred_Name: Irish
UMLS_CUI: C0087186
Legacy_Concept_Name: Irish
has exact synonym: Irish

Italian
type: Class
subclass of: European
definition: Denotes the inhabitants of Italy, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43857
Semantic_Type: Population Group
Preferred_Name: Italian
UMLS_CUI: C0337810
Legacy_Concept_Name: Italian
has exact synonym: Italian

Polish
type: Class
subclass of: European
definition: Denotes the inhabitants of Poland, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43858
Semantic_Type: Population Group
Preferred_Name: Polish
UMLS_CUI: C0220896
Legacy_Concept_Name: Polish
has exact synonym: Polish

Scottish
type: Class
subclass of: European
definition: Denotes the inhabitants of Scotland, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43859
Semantic_Type: Population Group
Preferred_Name: Scottish
UMLS_CUI: C0240966
Legacy_Concept_Name: Scottish
has exact synonym: Scottish

Russian
type: Class
subclass of: White
definition: Denotes the inhabitants of Russia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43860
Semantic_Type: Population Group
Preferred_Name: Russian
UMLS_CUI: C0337816
ALT_DEFINITION: A person having origins in any of the original peoples of Russia.
Legacy_Concept_Name: Russian
has exact synonym: RUSSIAN
has exact synonym: Russian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Swedish
type: Class
subclass of: European
definition: Denotes the inhabitants of Sweden, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43861
Semantic_Type: Population Group
Preferred_Name: Swedish
UMLS_CUI: C1710263
Legacy_Concept_Name: Swedish
has exact synonym: Swedish

Norwegian
type: Class
subclass of: European
definition: Denotes the inhabitants of Norway, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43862
Semantic_Type: Population Group
Preferred_Name: Norwegian
UMLS_CUI: C0337812
Legacy_Concept_Name: Norwegian
has exact synonym: Norwegian

Ukranian
type: Class
subclass of: European
definition: Denotes the inhabitants of Ukraine, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43863
Semantic_Type: Population Group
Preferred_Name: Ukranian
UMLS_CUI: C1710525
Legacy_Concept_Name: Ukranian
has exact synonym: Ukranian

Mongolian
type: Class
subclass of: Asian
definition: Denotes the inhabitants of Mongolia, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43864
Semantic_Type: Population Group
Preferred_Name: Mongolian
UMLS_CUI: C1709065
ALT_DEFINITION: A person having origins in any of the original peoples of Mongolia.
Legacy_Concept_Name: Mongolian
has exact synonym: MONGOLIAN
has exact synonym: Mongolian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Finnish
type: Class
subclass of: European
definition: Denotes the inhabitants of Finland, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43865
Semantic_Type: Population Group
Preferred_Name: Finnish
UMLS_CUI: C1711254
Legacy_Concept_Name: Finnish
has exact synonym: Finnish

Middle Eastern or North African
type: Class
subclass of: White
definition: Denotes a person from any of the countries of southwest Asia and northeastern Africa; this region includes those countries east of Egypt and south of Turkey and extending to Iran in the east.
imported from: ncit.owl
code: C43866
Semantic_Type: Population Group
Preferred_Name: Middle Eastern or North African
UMLS_CUI: C1553353
Legacy_Concept_Name: Middle_Eastern_or_North_African
has exact synonym: Middle Eastern or North African

Assyrian
type: Class
subclass of: Middle Eastern or North African
definition: A collective term used to identify indigenous peoples of northern Iraq and neighboring areas of Syria and Turkey, who also identify themselves as Aramaeans and Chaldeans. They are the survivors of the formerly extensive Aramaic- or Syriac- speaking Christian community of northern Iraq, southeastern Turkey, and northwestern Iran.
imported from: ncit.owl
code: C43867
Semantic_Type: Population Group
Preferred_Name: Assyrian
UMLS_CUI: C1553354
Legacy_Concept_Name: Assyrian
has exact synonym: Assyrian

Egyptian
type: Class
subclass of: Middle Eastern or North African
definition: Denotes the inhabitants of Egypt, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43868
Semantic_Type: Population Group
Preferred_Name: Egyptian
UMLS_CUI: C0337801
Legacy_Concept_Name: Egyptian
has exact synonym: Egyptian

Iranian
type: Class
subclass of: Middle Eastern or North African
definition: Denotes the inhabitants of Iran, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43869
Semantic_Type: Population Group
Preferred_Name: Iranian
UMLS_CUI: C1553355
Legacy_Concept_Name: Iranian
has exact synonym: Iranian

Iraqi
type: Class
subclass of: Middle Eastern or North African
definition: Denotes the inhabitants of Iraq, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43870
Semantic_Type: Population Group
Preferred_Name: Iraqi
UMLS_CUI: C1556087
Legacy_Concept_Name: Iraqi
has exact synonym: Iraqi

Lebanese
type: Class
subclass of: Middle Eastern or North African
definition: Denotes the inhabitants of Lebanon, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43871
Semantic_Type: Population Group
Preferred_Name: Lebanese
UMLS_CUI: C1553356
Legacy_Concept_Name: Lebanese
has exact synonym: Lebanese

Palestinian
type: Class
subclass of: Middle Eastern or North African
definition: Denotes those persons of mainly Arabic speakers who regard themselves as a distinct branch of the Arabic-speaking peoples, with family origin in Palestine being the defining characteristic.
imported from: ncit.owl
code: C43872
Semantic_Type: Population Group
Preferred_Name: Palestinian
UMLS_CUI: C0282539
Legacy_Concept_Name: Palestinian
has exact synonym: Palestinian

Syrian
type: Class
subclass of: Middle Eastern or North African
definition: Denotes the inhabitants of Syria, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43873
Semantic_Type: Population Group
Preferred_Name: Syrian
UMLS_CUI: C0337819
Legacy_Concept_Name: Syrian
has exact synonym: Syrian

Afghanistani
type: Class
subclass of: Middle Eastern or North African
definition: Denotes the inhabitants of Afghanistan, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43874
Semantic_Type: Population Group
Preferred_Name: Afghanistani
UMLS_CUI: C1553357
Legacy_Concept_Name: Afghanistani
has exact synonym: Afghanistani

Israeli
type: Class
subclass of: Middle Eastern or North African
definition: Denotes the inhabitants of Israel, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C43875
Semantic_Type: Population Group
Preferred_Name: Israeli
UMLS_CUI: C0240069
Legacy_Concept_Name: Israeli
has exact synonym: Israeli

Arab
type: Class
subclass of: Middle Eastern or North African
definition: Denotes a person with ethnic origins in the Semitic people originally from the Arabian peninsula and surrounding territories in the Middle East and northern Africa.
imported from: ncit.owl
code: C43876
Semantic_Type: Population Group
Preferred_Name: Arab
UMLS_CUI: C0282540
ALT_DEFINITION: A person having origins in any of the original peoples of the Arabian peninsula and surrounding territories in the Middle East and northern Africa.
Legacy_Concept_Name: Arab
has exact synonym: ARAB
has exact synonym: Arab
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

American Indian
type: Class
subclass of: American Indian or Alaska Native
definition: Denotes a person having origins in one of the indigenous peoples of North America, who lived on the continent prior to the European colonization. The term includes individuals belonging to a large number of tribes, states, and ethnic groups, many of them still enduring as communities.
imported from: ncit.owl
code: C43877
Semantic_Type: Population Group
Preferred_Name: American Indian
UMLS_CUI: C0002460
ALT_DEFINITION: The native people of North America.
Legacy_Concept_Name: American_Indian
has exact synonym: AMERICAN INDIAN
has exact synonym: American Indian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Abenaki
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43878
Semantic_Type: Population Group
Preferred_Name: Abenaki
UMLS_CUI: C1555038
Legacy_Concept_Name: Abenaki
has exact synonym: Abenaki

Algonquian
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43879
Semantic_Type: Population Group
Preferred_Name: Algonquian
UMLS_CUI: C1555039
Legacy_Concept_Name: Algonquian
has exact synonym: Algonquian

Apache
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43880
Semantic_Type: Population Group
Preferred_Name: Apache
UMLS_CUI: C0337855
Legacy_Concept_Name: Apache
has exact synonym: Apache

Chiricahua
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43881
Semantic_Type: Population Group
Preferred_Name: Chiricahua
UMLS_CUI: C1555040
Legacy_Concept_Name: Chiricahua
has exact synonym: Chiricahua

Fort Sill Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43882
Semantic_Type: Population Group
Preferred_Name: Fort Sill Apache
UMLS_CUI: C1555041
Legacy_Concept_Name: Fort_Sill_Apache
has exact synonym: Fort Sill Apache

Jicarilla Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43883
Semantic_Type: Population Group
Preferred_Name: Jicarilla Apache
UMLS_CUI: C1555042
Legacy_Concept_Name: Jicarilla_Apache
has exact synonym: Jicarilla Apache

Lipan Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43884
Semantic_Type: Population Group
Preferred_Name: Lipan Apache
UMLS_CUI: C1555043
Legacy_Concept_Name: Lipan_Apache
has exact synonym: Lipan Apache

Mescalero Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43885
Semantic_Type: Population Group
Preferred_Name: Mescalero Apache
UMLS_CUI: C1555044
Legacy_Concept_Name: Mescalero_Apache
has exact synonym: Mescalero Apache

Oklahoma Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43886
Semantic_Type: Population Group
Preferred_Name: Oklahoma Apache
UMLS_CUI: C1555045
Legacy_Concept_Name: Oklahoma_Apache
has exact synonym: Oklahoma Apache

Payson Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43887
Semantic_Type: Population Group
Preferred_Name: Payson Apache
UMLS_CUI: C1555046
Legacy_Concept_Name: Payson_Apache
has exact synonym: Payson Apache

San Carlos Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43888
Semantic_Type: Population Group
Preferred_Name: San Carlos Apache
UMLS_CUI: C1555047
Legacy_Concept_Name: San_Carlos_Apache
has exact synonym: San Carlos Apache

White Mountain Apache
type: Class
subclass of: Apache
imported from: ncit.owl
code: C43889
Semantic_Type: Population Group
Preferred_Name: White Mountain Apache
UMLS_CUI: C1555048
Legacy_Concept_Name: White_Mountain_Apache
has exact synonym: White Mountain Apache

Arapaho
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43890
Semantic_Type: Population Group
Preferred_Name: Arapaho
UMLS_CUI: C0682104
Legacy_Concept_Name: Arapaho
has exact synonym: Arapaho

Northern Arapaho
type: Class
subclass of: Arapaho
imported from: ncit.owl
code: C43891
Semantic_Type: Population Group
Preferred_Name: Northern Arapaho
UMLS_CUI: C1555049
Legacy_Concept_Name: Northern_Arapaho
has exact synonym: Northern Arapaho

Southern Arapaho
type: Class
subclass of: Arapaho
imported from: ncit.owl
code: C43892
Semantic_Type: Population Group
Preferred_Name: Southern Arapaho
UMLS_CUI: C1555050
Legacy_Concept_Name: Southern_Arapaho
has exact synonym: Southern Arapaho

Wind River Arapaho
type: Class
subclass of: Arapaho
imported from: ncit.owl
code: C43893
Semantic_Type: Population Group
Preferred_Name: Wind River Arapaho
UMLS_CUI: C1555051
Legacy_Concept_Name: Wind_River_Arapaho
has exact synonym: Wind River Arapaho

Arikara
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43894
Semantic_Type: Population Group
Preferred_Name: Arikara
UMLS_CUI: C1555052
Legacy_Concept_Name: Arikara
has exact synonym: Arikara

Assiniboine
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43895
Semantic_Type: Population Group
Preferred_Name: Assiniboine
UMLS_CUI: C1555053
Legacy_Concept_Name: Assiniboine
has exact synonym: Assiniboine

Assiniboine Sioux
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43896
Semantic_Type: Population Group
Preferred_Name: Assiniboine Sioux
UMLS_CUI: C1555054
Legacy_Concept_Name: Assiniboine_Sioux
has exact synonym: Assiniboine Sioux

Fort Peck Assiniboine Sioux
type: Class
subclass of: Assiniboine Sioux
imported from: ncit.owl
code: C43897
Semantic_Type: Population Group
Preferred_Name: Fort Peck Assiniboine Sioux
UMLS_CUI: C1555055
Legacy_Concept_Name: Fort_Peck_Assiniboine_Sioux
has exact synonym: Fort Peck Assiniboine Sioux

Bannock
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43898
Semantic_Type: Population Group
Preferred_Name: Bannock
UMLS_CUI: C1555056
Legacy_Concept_Name: Bannock
has exact synonym: Bannock

Blackfeet
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43899
Semantic_Type: Population Group
Preferred_Name: Blackfeet
UMLS_CUI: C0337860
Legacy_Concept_Name: Blackfeet
has exact synonym: Blackfeet

Brotherton
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43900
Semantic_Type: Population Group
Preferred_Name: Brotherton
UMLS_CUI: C1555057
Legacy_Concept_Name: Brotherton
has exact synonym: Brotherton

Burt Lake Band
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43901
Semantic_Type: Population Group
Preferred_Name: Burt Lake Band
UMLS_CUI: C1555058
Legacy_Concept_Name: Burt_Lake_Band
has exact synonym: Burt Lake Band

Caddo
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43902
Semantic_Type: Population Group
Preferred_Name: Caddo
UMLS_CUI: C1555059
Legacy_Concept_Name: Caddo
has exact synonym: Caddo

Oklahoma Cado
type: Class
subclass of: Caddo
imported from: ncit.owl
code: C43903
Semantic_Type: Population Group
Preferred_Name: Oklahoma Cado
UMLS_CUI: C1555060
Legacy_Concept_Name: Oklahoma_Cado
has exact synonym: Oklahoma Cado

Cahuilla
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43904
Semantic_Type: Population Group
Preferred_Name: Cahuilla
UMLS_CUI: C1555061
Legacy_Concept_Name: Cahuilla
has exact synonym: Cahuilla

Agua Caliente Cahuilla
type: Class
subclass of: Cahuilla
imported from: ncit.owl
code: C43905
Semantic_Type: Population Group
Preferred_Name: Agua Caliente Cahuilla
UMLS_CUI: C1555062
Legacy_Concept_Name: Agua_Caliente_Cahuilla
has exact synonym: Agua Caliente Cahuilla

Augustine
type: Class
subclass of: Cahuilla
imported from: ncit.owl
code: C43909
Semantic_Type: Population Group
Preferred_Name: Augustine
UMLS_CUI: C1555063
Legacy_Concept_Name: Augustine
has exact synonym: Augustine

Cabazon
type: Class
subclass of: Cahuilla
imported from: ncit.owl
code: C43910
Semantic_Type: Population Group
Preferred_Name: Cabazon
UMLS_CUI: C1555064
Legacy_Concept_Name: Cabazon
has exact synonym: Cabazon

Los Coyotes
type: Class
subclass of: Cahuilla
imported from: ncit.owl
code: C43911
Semantic_Type: Population Group
Preferred_Name: Los Coyotes
UMLS_CUI: C1555065
Legacy_Concept_Name: Los_Coyotes
has exact synonym: Los Coyotes

Morongo
type: Class
subclass of: Cahuilla
imported from: ncit.owl
code: C43912
Semantic_Type: Population Group
Preferred_Name: Morongo
UMLS_CUI: C1555066
Legacy_Concept_Name: Morongo
has exact synonym: Morongo

Santa Rosa Cahuilla
type: Class
subclass of: Cahuilla
imported from: ncit.owl
code: C43913
Semantic_Type: Population Group
Preferred_Name: Santa Rosa Cahuilla
UMLS_CUI: C1555067
Legacy_Concept_Name: Santa_Rosa_Cahuilla
has exact synonym: Santa Rosa Cahuilla

Torres-Martinez
type: Class
subclass of: Cahuilla
imported from: ncit.owl
code: C43914
Semantic_Type: Population Group
Preferred_Name: Torres-Martinez
UMLS_CUI: C1555068
Legacy_Concept_Name: Torres_Martinez
has exact synonym: Torres-Martinez

California Tribes
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43915
Semantic_Type: Population Group
Preferred_Name: California Tribes
UMLS_CUI: C1555069
Legacy_Concept_Name: California_Tribes
has exact synonym: California Tribes

Canadian and Latin American Indian
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43916
Semantic_Type: Population Group
Preferred_Name: Canadian and Latin American Indian
UMLS_CUI: C1555083
Legacy_Concept_Name: Canadian_and_Latin_American_Indian
has exact synonym: Canadian and Latin American Indian

Catawba
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43917
Semantic_Type: Population Group
Preferred_Name: Catawba
UMLS_CUI: C0682102
Legacy_Concept_Name: Catawba
has exact synonym: Catawba

Cayuse
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43918
Semantic_Type: Population Group
Preferred_Name: Cayuse
UMLS_CUI: C1555088
Legacy_Concept_Name: Cayuse
has exact synonym: Cayuse

Chehalis
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43919
Semantic_Type: Population Group
Preferred_Name: Chehalis
UMLS_CUI: C1555089
Legacy_Concept_Name: Chehalis
has exact synonym: Chehalis

Chemakuan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43920
Semantic_Type: Population Group
Preferred_Name: Chemakuan
UMLS_CUI: C1555090
Legacy_Concept_Name: Chemakuan
has exact synonym: Chemakuan

Hoh
type: Class
subclass of: Chemakuan
imported from: ncit.owl
code: C43921
Semantic_Type: Population Group
Preferred_Name: Hoh
UMLS_CUI: C1555091
Legacy_Concept_Name: Hoh
has exact synonym: Hoh

Quileute
type: Class
subclass of: Chemakuan
imported from: ncit.owl
code: C43922
Semantic_Type: Population Group
Preferred_Name: Quileute
UMLS_CUI: C1555092
Legacy_Concept_Name: Quileute
has exact synonym: Quileute

Chemehuevi
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43923
Semantic_Type: Population Group
Preferred_Name: Chemehuevi
UMLS_CUI: C1555093
Legacy_Concept_Name: Chemehuevi
has exact synonym: Chemehuevi

Cherokee
type: Class
subclass of: Cherokee Shawnee
imported from: ncit.owl
code: C43924
Semantic_Type: Population Group
Preferred_Name: Cherokee
UMLS_CUI: C0682103
Legacy_Concept_Name: Cherokee
has exact synonym: Cherokee

Cherokee Shawnee
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43925
Semantic_Type: Population Group
Preferred_Name: Cherokee Shawnee
UMLS_CUI: C1555104
Legacy_Concept_Name: Cherokee_Shawnee
has exact synonym: Cherokee Shawnee

Cheyenne
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43926
Semantic_Type: Population Group
Preferred_Name: Cheyenne
UMLS_CUI: C0682106
Legacy_Concept_Name: Cheyenne
has exact synonym: Cheyenne

Northern Cheyenne
type: Class
subclass of: Cheyenne
imported from: ncit.owl
code: C43927
Semantic_Type: Population Group
Preferred_Name: Northern Cheyenne
UMLS_CUI: C1555105
Legacy_Concept_Name: Northern_Cheyenne
has exact synonym: Northern Cheyenne

Southern Cheyenne
type: Class
subclass of: Cheyenne
imported from: ncit.owl
code: C43928
Semantic_Type: Population Group
Preferred_Name: Southern Cheyenne
UMLS_CUI: C1555106
Legacy_Concept_Name: Southern_Cheyenne
has exact synonym: Southern Cheyenne

Cheyenne-Arapaho
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43929
Semantic_Type: Population Group
Preferred_Name: Cheyenne-Arapaho
UMLS_CUI: C1555107
Legacy_Concept_Name: Cheyenne_Arapaho
has exact synonym: Cheyenne-Arapaho

Chickahominy
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43930
Semantic_Type: Population Group
Preferred_Name: Chickahominy
UMLS_CUI: C1555108
Legacy_Concept_Name: Chickahominy
has exact synonym: Chickahominy

Eastern Chickahominy
type: Class
subclass of: Chickahominy
imported from: ncit.owl
code: C43931
Semantic_Type: Population Group
Preferred_Name: Eastern Chickahominy
UMLS_CUI: C1555109
Legacy_Concept_Name: Eastern_Chickahominy
has exact synonym: Eastern Chickahominy

Western Chickahominy
type: Class
subclass of: Chickahominy
imported from: ncit.owl
code: C43932
Semantic_Type: Population Group
Preferred_Name: Western Chickahominy
UMLS_CUI: C1555110
Legacy_Concept_Name: Western_Chickahominy
has exact synonym: Western Chickahominy

Chickasaw
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43933
Semantic_Type: Population Group
Preferred_Name: Chickasaw
UMLS_CUI: C0682101
Legacy_Concept_Name: Chickasaw
has exact synonym: Chickasaw

Chinook
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43934
Semantic_Type: Population Group
Preferred_Name: Chinook
UMLS_CUI: C1555111
Legacy_Concept_Name: Chinook
has exact synonym: Chinook

Chippewa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43935
Semantic_Type: Population Group
Preferred_Name: Chippewa
UMLS_CUI: C0337862
Legacy_Concept_Name: Chippewa
has exact synonym: Chippewa

Chippewa Cree
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43936
Semantic_Type: Population Group
Preferred_Name: Chippewa Cree
UMLS_CUI: C1555144
Legacy_Concept_Name: Chippewa_Cree
has exact synonym: Chippewa Cree

Rocky Boy's Chippewa Cree
type: Class
subclass of: Chippewa Cree
imported from: ncit.owl
code: C43937
Semantic_Type: Population Group
Preferred_Name: Rocky Boy's Chippewa Cree
UMLS_CUI: C1555145
Legacy_Concept_Name: Rocky_Boy_s_Chippewa_Cree
has exact synonym: Rocky Boy's Chippewa Cree

Chitimacha
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43938
Semantic_Type: Population Group
Preferred_Name: Chitimacha
UMLS_CUI: C1555146
Legacy_Concept_Name: Chitimacha
has exact synonym: Chitimacha

Choctaw
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43939
Semantic_Type: Population Group
Preferred_Name: Choctaw
UMLS_CUI: C0682100
Legacy_Concept_Name: Choctaw
has exact synonym: Choctaw

Clifton Choctaw
type: Class
subclass of: Choctaw
imported from: ncit.owl
code: C43940
Semantic_Type: Population Group
Preferred_Name: Clifton Choctaw
UMLS_CUI: C1555147
Legacy_Concept_Name: Clifton_Choctaw
has exact synonym: Clifton Choctaw

Jena Choctaw
type: Class
subclass of: Choctaw
imported from: ncit.owl
code: C43941
Semantic_Type: Population Group
Preferred_Name: Jena Choctaw
UMLS_CUI: C1555148
Legacy_Concept_Name: Jena_Choctaw
has exact synonym: Jena Choctaw

Mississippi Choctaw
type: Class
subclass of: Choctaw
imported from: ncit.owl
code: C43942
Semantic_Type: Population Group
Preferred_Name: Mississippi Choctaw
UMLS_CUI: C1555149
Legacy_Concept_Name: Mississippi_Choctaw
has exact synonym: Mississippi Choctaw

Mowa Band of Choctaw
type: Class
subclass of: Choctaw
imported from: ncit.owl
code: C43943
Semantic_Type: Population Group
Preferred_Name: Mowa Band of Choctaw
UMLS_CUI: C1555150
Legacy_Concept_Name: Mowa_Band_of_Choctaw
has exact synonym: Mowa Band of Choctaw

Oklahoma Choctaw
type: Class
subclass of: Choctaw
imported from: ncit.owl
code: C43944
Semantic_Type: Population Group
Preferred_Name: Oklahoma Choctaw
UMLS_CUI: C1555151
Legacy_Concept_Name: Oklahoma_Choctaw
has exact synonym: Oklahoma Choctaw

Chumash
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43945
Semantic_Type: Population Group
Preferred_Name: Chumash
UMLS_CUI: C0682116
Legacy_Concept_Name: Chumash
has exact synonym: Chumash

Santa Ynez
type: Class
subclass of: Chumash
imported from: ncit.owl
code: C43946
Semantic_Type: Population Group
Preferred_Name: Santa Ynez
UMLS_CUI: C1555152
Legacy_Concept_Name: Santa_Ynez
has exact synonym: Santa Ynez

Clear Lake
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43947
Semantic_Type: Population Group
Preferred_Name: Clear Lake
UMLS_CUI: C1555153
Legacy_Concept_Name: Clear_Lake
has exact synonym: Clear Lake

Coeur D'Alene
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43948
Semantic_Type: Population Group
Preferred_Name: Coeur D'Alene
UMLS_CUI: C1555154
Legacy_Concept_Name: Coeur_D_Alene
has exact synonym: Coeur D'Alene

Coharie
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43949
Semantic_Type: Population Group
Preferred_Name: Coharie
UMLS_CUI: C1555155
Legacy_Concept_Name: Coharie
has exact synonym: Coharie

Colorado River
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43950
Semantic_Type: Population Group
Preferred_Name: Colorado River
UMLS_CUI: C1555156
Legacy_Concept_Name: Colorado_River
has exact synonym: Colorado River

Colville
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43951
Semantic_Type: Population Group
Preferred_Name: Colville
UMLS_CUI: C1555157
Legacy_Concept_Name: Colville
has exact synonym: Colville

Comanche
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43952
Semantic_Type: Population Group
Preferred_Name: Comanche
UMLS_CUI: C0682105
Legacy_Concept_Name: Comanche
has exact synonym: Comanche

Oklahoma Comanche
type: Class
subclass of: Comanche
imported from: ncit.owl
code: C43953
Semantic_Type: Population Group
Preferred_Name: Oklahoma Comanche
UMLS_CUI: C1555158
Legacy_Concept_Name: Oklahoma_Comanche
has exact synonym: Oklahoma Comanche

Coos Lower Umpqua Siuslaw
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43954
Semantic_Type: Population Group
Preferred_Name: Coos Lower Umpqua Siuslaw
UMLS_CUI: C1555159
Legacy_Concept_Name: Coos_Lower_Umpqua_Siuslaw
has exact synonym: Coos Lower Umpqua Siuslaw

Coos
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43955
Semantic_Type: Population Group
Preferred_Name: Coos
UMLS_CUI: C1555160
Legacy_Concept_Name: Coos
has exact synonym: Coos

Coquilles
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43956
Semantic_Type: Population Group
Preferred_Name: Coquilles
UMLS_CUI: C1555161
Legacy_Concept_Name: Coquilles
has exact synonym: Coquilles

Costanoan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43957
Semantic_Type: Population Group
Preferred_Name: Costanoan
UMLS_CUI: C1555162
Legacy_Concept_Name: Costanoan
has exact synonym: Costanoan

Coushatta
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43958
Semantic_Type: Population Group
Preferred_Name: Coushatta
UMLS_CUI: C0337865
Legacy_Concept_Name: Coushatta
has exact synonym: Coushatta

Alabama Coushatta
type: Class
subclass of: Coushatta
imported from: ncit.owl
code: C43959
Semantic_Type: Population Group
Preferred_Name: Alabama Coushatta
UMLS_CUI: C1555163
Legacy_Concept_Name: Alabama_Coushatta
has exact synonym: Alabama Coushatta

Cowlitz
type: Class
subclass of: Yakama Cowlitz
imported from: ncit.owl
code: C43961
Semantic_Type: Population Group
Preferred_Name: Cowlitz
UMLS_CUI: C1555164
Legacy_Concept_Name: Cowlitz
has exact synonym: Cowlitz

Cree
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43962
Semantic_Type: Population Group
Preferred_Name: Cree
UMLS_CUI: C0702268
Legacy_Concept_Name: Cree
has exact synonym: Cree

Creek
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43963
Semantic_Type: Population Group
Preferred_Name: Creek
UMLS_CUI: C1555165
Legacy_Concept_Name: Creek
has exact synonym: Creek

Croatan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43964
Semantic_Type: Population Group
Preferred_Name: Croatan
UMLS_CUI: C1555178
Legacy_Concept_Name: Croatan
has exact synonym: Croatan

Crow
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43965
Semantic_Type: Population Group
Preferred_Name: Crow
UMLS_CUI: C1555179
Legacy_Concept_Name: Crow
has exact synonym: Crow

Cupeno
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43967
Semantic_Type: Population Group
Preferred_Name: Cupeno
UMLS_CUI: C1555180
Legacy_Concept_Name: Cupeno
has exact synonym: Cupeno

Agua Caliente
type: Class
subclass of: Cupeno
imported from: ncit.owl
code: C43968
Semantic_Type: Population Group
Preferred_Name: Agua Caliente
UMLS_CUI: C1555181
Legacy_Concept_Name: Agua_Caliente
has exact synonym: Agua Caliente

Delaware
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43969
Semantic_Type: Population Group
Preferred_Name: Delaware
UMLS_CUI: C1555182
Legacy_Concept_Name: Delaware_Indian
has exact synonym: Delaware

Diegueno
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43970
Semantic_Type: Population Group
Preferred_Name: Diegueno
UMLS_CUI: C0337867
Legacy_Concept_Name: Diegueno
has exact synonym: Diegueno
has exact synonym: Diegueño

Eastern Tribes
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43971
Semantic_Type: Population Group
Preferred_Name: Eastern Tribes
UMLS_CUI: C1555198
Legacy_Concept_Name: Eastern_Tribes
has exact synonym: Eastern Tribes

Esselen
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43972
Semantic_Type: Population Group
Preferred_Name: Esselen
UMLS_CUI: C1555214
Legacy_Concept_Name: Esselen
has exact synonym: Esselen

Fort Belknap
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43973
Semantic_Type: Population Group
Preferred_Name: Fort Belknap
UMLS_CUI: C1555215
Legacy_Concept_Name: Fort_Belknap
has exact synonym: Fort Belknap

Fort Berthold
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43974
Semantic_Type: Population Group
Preferred_Name: Fort Berthold
UMLS_CUI: C1555216
Legacy_Concept_Name: Fort_Berthold
has exact synonym: Fort Berthold

Fort McDowell
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43975
Semantic_Type: Population Group
Preferred_Name: Fort McDowell
UMLS_CUI: C1555217
Legacy_Concept_Name: Fort_McDowell
has exact synonym: Fort McDowell
has exact synonym: Fort Mcdowell

Fort Hall
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43976
Semantic_Type: Population Group
Preferred_Name: Fort Hall
UMLS_CUI: C1555218
Legacy_Concept_Name: Fort_Hall
has exact synonym: Fort Hall

Gabrieleno
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43977
Semantic_Type: Population Group
Preferred_Name: Gabrieleno
UMLS_CUI: C1555219
Legacy_Concept_Name: Gabrieleno
has exact synonym: Gabrieleno

Grand Ronde
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43978
Semantic_Type: Population Group
Preferred_Name: Grand Ronde
UMLS_CUI: C1555220
Legacy_Concept_Name: Grand_Ronde
has exact synonym: Grand Ronde

Gros Ventres
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43979
Semantic_Type: Population Group
Preferred_Name: Gros Ventres
UMLS_CUI: C1555221
Legacy_Concept_Name: Gros_Ventres
has exact synonym: Gros Ventres

Atsina
type: Class
subclass of: Gros Ventres
imported from: ncit.owl
code: C43980
Semantic_Type: Population Group
Preferred_Name: Atsina
UMLS_CUI: C1555222
Legacy_Concept_Name: Atsina
has exact synonym: Atsina

Haliwa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43981
Semantic_Type: Population Group
Preferred_Name: Haliwa
UMLS_CUI: C1555223
Legacy_Concept_Name: Haliwa
has exact synonym: Haliwa

Hidatsa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43982
Semantic_Type: Population Group
Preferred_Name: Hidatsa
UMLS_CUI: C1555224
Legacy_Concept_Name: Hidatsa
has exact synonym: Hidatsa

Hoopa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43983
Semantic_Type: Population Group
Preferred_Name: Hoopa
UMLS_CUI: C1555225
Legacy_Concept_Name: Hoopa
has exact synonym: Hoopa

Trinity
type: Class
subclass of: Hoopa
imported from: ncit.owl
code: C43984
Semantic_Type: Population Group
Preferred_Name: Trinity
UMLS_CUI: C1555226
Legacy_Concept_Name: Trinity
has exact synonym: Trinity

Whilkut
type: Class
subclass of: Hoopa
imported from: ncit.owl
code: C43985
Semantic_Type: Population Group
Preferred_Name: Whilkut
UMLS_CUI: C1555227
Legacy_Concept_Name: Whilkut
has exact synonym: Whilkut

Hoopa Extension
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43986
Semantic_Type: Population Group
Preferred_Name: Hoopa Extension
UMLS_CUI: C1555228
Legacy_Concept_Name: Hoopa_Extension
has exact synonym: Hoopa Extension

Houma
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43987
Semantic_Type: Population Group
Preferred_Name: Houma
UMLS_CUI: C1555229
Legacy_Concept_Name: Houma
has exact synonym: Houma

Inaja-Cosmit
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43988
Semantic_Type: Population Group
Preferred_Name: Inaja-Cosmit
UMLS_CUI: C1555230
Legacy_Concept_Name: Inaja_Cosmit
has exact synonym: Inaja-Cosmit

Iowa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43989
Semantic_Type: Population Group
Preferred_Name: Iowa
UMLS_CUI: C1555231
Legacy_Concept_Name: Iowa_Indian
has exact synonym: Iowa

Iowa of Kansas-Nebraska
type: Class
subclass of: Iowa
imported from: ncit.owl
code: C43990
Semantic_Type: Population Group
Preferred_Name: Iowa of Kansas-Nebraska
UMLS_CUI: C1555232
Legacy_Concept_Name: Iowa_of_Kansas_Nebraska
has exact synonym: Iowa of Kansas-Nebraska

Iowa of Oklahoma
type: Class
subclass of: Iowa
imported from: ncit.owl
code: C43991
Semantic_Type: Population Group
Preferred_Name: Iowa of Oklahoma
UMLS_CUI: C1555233
Legacy_Concept_Name: Iowa_of_Oklahoma
has exact synonym: Iowa of Oklahoma

Iroquois
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43992
Semantic_Type: Population Group
Preferred_Name: Iroquois
UMLS_CUI: C0682098
Legacy_Concept_Name: Iroquois
has exact synonym: Iroquois

Juaneno
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43993
Semantic_Type: Population Group
Preferred_Name: Juaneno
UMLS_CUI: C1555243
Legacy_Concept_Name: Juaneno
has exact synonym: Juaneno

Kalispel
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43994
Semantic_Type: Population Group
Preferred_Name: Kalispel
UMLS_CUI: C1555244
Legacy_Concept_Name: Kalispel
has exact synonym: Kalispel

Karuk
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43995
Semantic_Type: Population Group
Preferred_Name: Karuk
UMLS_CUI: C1555245
Legacy_Concept_Name: Karuk
has exact synonym: Karuk

Kaw
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43996
Semantic_Type: Population Group
Preferred_Name: Kaw
UMLS_CUI: C1555246
Legacy_Concept_Name: Kaw
has exact synonym: Kaw

Kickapoo
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C43997
Semantic_Type: Population Group
Preferred_Name: Kickapoo
UMLS_CUI: C1555247
Legacy_Concept_Name: Kickapoo
has exact synonym: Kickapoo

Oklahoma Kickapoo
type: Class
subclass of: Kickapoo
imported from: ncit.owl
code: C43998
Semantic_Type: Population Group
Preferred_Name: Oklahoma Kickapoo
UMLS_CUI: C1555248
Legacy_Concept_Name: Oklahoma_Kickapoo
has exact synonym: Oklahoma Kickapoo

Texas Kickapoo
type: Class
subclass of: Kickapoo
imported from: ncit.owl
code: C43999
Semantic_Type: Population Group
Preferred_Name: Texas Kickapoo
UMLS_CUI: C1555249
Legacy_Concept_Name: Texas_Kickapoo
has exact synonym: Texas Kickapoo

Kiowa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44000
Semantic_Type: Population Group
Preferred_Name: Kiowa
UMLS_CUI: C1555250
Legacy_Concept_Name: Kiowa
has exact synonym: Kiowa

Oklahoma Kiowa
type: Class
subclass of: Kiowa
imported from: ncit.owl
code: C44001
Semantic_Type: Population Group
Preferred_Name: Oklahoma Kiowa
UMLS_CUI: C1555251
Legacy_Concept_Name: Oklahoma_Kiowa
has exact synonym: Oklahoma Kiowa

Klallam
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44002
Semantic_Type: Population Group
Preferred_Name: Klallam
UMLS_CUI: C1555252
Legacy_Concept_Name: Klallam
has exact synonym: Klallam

Jamestown
type: Class
subclass of: Klallam
imported from: ncit.owl
code: C44003
Semantic_Type: Population Group
Preferred_Name: Jamestown
UMLS_CUI: C1555253
Legacy_Concept_Name: Jamestown
has exact synonym: Jamestown

Lower Elwha
type: Class
subclass of: Klallam
imported from: ncit.owl
code: C44004
Semantic_Type: Population Group
Preferred_Name: Lower Elwha
UMLS_CUI: C1555254
Legacy_Concept_Name: Lower_Elwha
has exact synonym: Lower Elwha

Port Gamble Klallam
type: Class
subclass of: Klallam
imported from: ncit.owl
code: C44005
Semantic_Type: Population Group
Preferred_Name: Port Gamble Klallam
UMLS_CUI: C1555255
Legacy_Concept_Name: Port_Gamble_Klallam
has exact synonym: Port Gamble Klallam

Klamath
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44006
Semantic_Type: Population Group
Preferred_Name: Klamath
UMLS_CUI: C1555256
Legacy_Concept_Name: Klamath
has exact synonym: Klamath

Konkow
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44007
Semantic_Type: Population Group
Preferred_Name: Konkow
UMLS_CUI: C1555257
Legacy_Concept_Name: Konkow
has exact synonym: Konkow

Kootenai
type: Class
subclass of: Salish and Kootenai
imported from: ncit.owl
code: C44008
Semantic_Type: Population Group
Preferred_Name: Kootenai
UMLS_CUI: C1555258
Legacy_Concept_Name: Kootenai
has exact synonym: Kootenai

Lassik
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44009
Semantic_Type: Population Group
Preferred_Name: Lassik
UMLS_CUI: C1555259
Legacy_Concept_Name: Lassik
has exact synonym: Lassik

Long Island
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44010
Semantic_Type: Population Group
Preferred_Name: Long Island
UMLS_CUI: C1555260
Legacy_Concept_Name: Long_Island
has exact synonym: Long Island

Matinecock
type: Class
subclass of: Long Island
imported from: ncit.owl
code: C44011
Semantic_Type: Population Group
Preferred_Name: Matinecock
UMLS_CUI: C1555261
Legacy_Concept_Name: Matinecock
has exact synonym: Matinecock

Montauk
type: Class
subclass of: Long Island
imported from: ncit.owl
code: C44012
Semantic_Type: Population Group
Preferred_Name: Montauk
UMLS_CUI: C1555262
Legacy_Concept_Name: Montauk
has exact synonym: Montauk

Poospatuck
type: Class
subclass of: Long Island
imported from: ncit.owl
code: C44013
Semantic_Type: Population Group
Preferred_Name: Poospatuck
UMLS_CUI: C1555263
Legacy_Concept_Name: Poospatuck
has exact synonym: Poospatuck

Setauket
type: Class
subclass of: Long Island
imported from: ncit.owl
code: C44014
Semantic_Type: Population Group
Preferred_Name: Setauket
UMLS_CUI: C1555264
Legacy_Concept_Name: Setauket
has exact synonym: Setauket

Luiseno
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44015
Semantic_Type: Population Group
Preferred_Name: Luiseno
UMLS_CUI: C0682114
Legacy_Concept_Name: Luiseno
has exact synonym: Luiseno

La Jolla
type: Class
subclass of: Luiseno
imported from: ncit.owl
code: C44016
Semantic_Type: Population Group
Preferred_Name: La Jolla
UMLS_CUI: C1555265
Legacy_Concept_Name: La_Jolla
has exact synonym: La Jolla

Pala
type: Class
subclass of: Luiseno
imported from: ncit.owl
code: C44017
Semantic_Type: Population Group
Preferred_Name: Pala
UMLS_CUI: C1555266
Legacy_Concept_Name: Pala
has exact synonym: Pala

Pauma
type: Class
subclass of: Luiseno
imported from: ncit.owl
code: C44018
Semantic_Type: Population Group
Preferred_Name: Pauma
UMLS_CUI: C1555267
Legacy_Concept_Name: Pauma
has exact synonym: Pauma

Pechanga
type: Class
subclass of: Luiseno
imported from: ncit.owl
code: C44019
Semantic_Type: Population Group
Preferred_Name: Pechanga
UMLS_CUI: C1555268
Legacy_Concept_Name: Pechanga
has exact synonym: Pechanga

Soboba
type: Class
subclass of: Luiseno
imported from: ncit.owl
code: C44020
Semantic_Type: Population Group
Preferred_Name: Soboba
UMLS_CUI: C1555269
Legacy_Concept_Name: Soboba
has exact synonym: SoboInOwlba

Twenty-Nine Palms
type: Class
subclass of: Luiseno
imported from: ncit.owl
code: C44021
Semantic_Type: Population Group
Preferred_Name: Twenty-Nine Palms
UMLS_CUI: C1555270
Legacy_Concept_Name: Twenty_Nine_Palms
has exact synonym: Twenty-Nine Palms

Temecula
type: Class
subclass of: Luiseno
imported from: ncit.owl
code: C44022
Semantic_Type: Population Group
Preferred_Name: Temecula
UMLS_CUI: C1555271
Legacy_Concept_Name: Temecula
has exact synonym: Temecula

Lumbee
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44023
Semantic_Type: Population Group
Preferred_Name: Lumbee
UMLS_CUI: C1555272
Legacy_Concept_Name: Lumbee
has exact synonym: Lumbee

Lummi
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44024
Semantic_Type: Population Group
Preferred_Name: Lummi
UMLS_CUI: C1555273
Legacy_Concept_Name: Lummi
has exact synonym: Lummi

Maidu
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44025
Semantic_Type: Population Group
Preferred_Name: Maidu
UMLS_CUI: C1555274
Legacy_Concept_Name: Maidu
has exact synonym: Maidu

Mountain Maidu
type: Class
subclass of: Maidu
imported from: ncit.owl
code: C44026
Semantic_Type: Population Group
Preferred_Name: Mountain Maidu
UMLS_CUI: C1555275
Legacy_Concept_Name: Mountain_Maidu
has exact synonym: Mountain Maidu

Nishinam
type: Class
subclass of: Maidu
imported from: ncit.owl
code: C44027
Semantic_Type: Population Group
Preferred_Name: Nishinam
UMLS_CUI: C1551415
Legacy_Concept_Name: Nishinam
has exact synonym: Nishinam

Makah
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44028
Semantic_Type: Population Group
Preferred_Name: Makah
UMLS_CUI: C1551416
Legacy_Concept_Name: Makah
has exact synonym: Makah

Maliseet
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44029
Semantic_Type: Population Group
Preferred_Name: Maliseet
UMLS_CUI: C1551417
Legacy_Concept_Name: Maliseet
has exact synonym: Maliseet

Mandan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44030
Semantic_Type: Population Group
Preferred_Name: Mandan
UMLS_CUI: C1551418
Legacy_Concept_Name: Mandan
has exact synonym: Mandan

Mattaponi
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44031
Semantic_Type: Population Group
Preferred_Name: Mattaponi
UMLS_CUI: C1551419
Legacy_Concept_Name: Mattaponi
has exact synonym: Mattaponi

Menominee
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44032
Semantic_Type: Population Group
Preferred_Name: Menominee
UMLS_CUI: C1551420
Legacy_Concept_Name: Menominee
has exact synonym: Menominee

Miami
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44033
Semantic_Type: Population Group
Preferred_Name: Miami
UMLS_CUI: C1551421
Legacy_Concept_Name: Miami
has exact synonym: Miami

Illinois Miami
type: Class
subclass of: Miami
imported from: ncit.owl
code: C44034
Semantic_Type: Population Group
Preferred_Name: Illinois Miami
UMLS_CUI: C1551422
Legacy_Concept_Name: Illinois_Miami
has exact synonym: Illinois Miami

Indiana Miami
type: Class
subclass of: Miami
imported from: ncit.owl
code: C44035
Semantic_Type: Population Group
Preferred_Name: Indiana Miami
UMLS_CUI: C1551423
Legacy_Concept_Name: Indiana_Miami
has exact synonym: Indiana Miami

Oklahoma Miami
type: Class
subclass of: Miami
imported from: ncit.owl
code: C44036
Semantic_Type: Population Group
Preferred_Name: Oklahoma Miami
UMLS_CUI: C1551424
Legacy_Concept_Name: Oklahoma_Miami
has exact synonym: Oklahoma Miami

Miccosukee
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44037
Semantic_Type: Population Group
Preferred_Name: Miccosukee
UMLS_CUI: C1551425
Legacy_Concept_Name: Miccosukee
has exact synonym: Miccosukee

Micmac
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44038
Semantic_Type: Population Group
Preferred_Name: Micmac
UMLS_CUI: C1551426
Legacy_Concept_Name: Micmac
has exact synonym: Micmac

Aroostook
type: Class
subclass of: Micmac
imported from: ncit.owl
code: C44039
Semantic_Type: Population Group
Preferred_Name: Aroostook
UMLS_CUI: C1551427
Legacy_Concept_Name: Aroostook
has exact synonym: Aroostook

Mission Indians
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44040
Semantic_Type: Population Group
Preferred_Name: Mission Indians
UMLS_CUI: C1551428
Legacy_Concept_Name: Mission_Indians
has exact synonym: Mission Indians

Miwok
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44041
Semantic_Type: Population Group
Preferred_Name: Miwok
UMLS_CUI: C1551429
Legacy_Concept_Name: Miwok
has exact synonym: Miwok

Modoc
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44042
Semantic_Type: Population Group
Preferred_Name: Modoc
UMLS_CUI: C1551430
Legacy_Concept_Name: Modoc
has exact synonym: Modoc

Mohegan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44043
Semantic_Type: Population Group
Preferred_Name: Mohegan
UMLS_CUI: C1551431
Legacy_Concept_Name: Mohegan
has exact synonym: Mohegan

Mono
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44044
Semantic_Type: Population Group
Preferred_Name: Mono
UMLS_CUI: C1551432
Legacy_Concept_Name: Mono
has exact synonym: Mono

Nanticoke
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44045
Semantic_Type: Population Group
Preferred_Name: Nanticoke
UMLS_CUI: C1551433
Legacy_Concept_Name: Nanticoke
has exact synonym: Nanticoke

Narragansett
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44046
Semantic_Type: Population Group
Preferred_Name: Narragansett
UMLS_CUI: C1551434
Legacy_Concept_Name: Narragansett
has exact synonym: Narragansett

Dine
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44048
Semantic_Type: Population Group
Preferred_Name: Dine
UMLS_CUI: C0337879
Legacy_Concept_Name: Dine
has exact synonym: Dine
has exact synonym: Navaho
has exact synonym: Navajo

Alamo Dine
type: Class
subclass of: Dine
imported from: ncit.owl
code: C44049
Semantic_Type: Population Group
Preferred_Name: Alamo Dine
UMLS_CUI: C1551435
Legacy_Concept_Name: Alamo_Dine
has exact synonym: Alamo Dine
has exact synonym: Alamo Navaho
has exact synonym: Alamo Navajo

Canoncito Dine
type: Class
subclass of: Dine
imported from: ncit.owl
code: C44050
Semantic_Type: Population Group
Preferred_Name: Canoncito Dine
UMLS_CUI: C1551436
Legacy_Concept_Name: Canoncito_Dine
has exact synonym: Canoncito Dine
has exact synonym: Canoncito Navaho
has exact synonym: Canoncito Navajo

Ramah Dine
type: Class
subclass of: Dine
imported from: ncit.owl
code: C44051
Semantic_Type: Population Group
Preferred_Name: Ramah Dine
UMLS_CUI: C1551437
Legacy_Concept_Name: Ramah_Dine
has exact synonym: Ramah Dine
has exact synonym: Ramah Navaho
has exact synonym: Ramah Navajo

Nez Perce
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44052
Semantic_Type: Population Group
Preferred_Name: Nez Perce
UMLS_CUI: C0337880
Legacy_Concept_Name: Nez_Perce
has exact synonym: Nez Perce
has exact synonym: Nez Percé

Nomalaki
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44053
Semantic_Type: Population Group
Preferred_Name: Nomalaki
UMLS_CUI: C1551438
Legacy_Concept_Name: Nomalaki
has exact synonym: Nomalaki

Northwest Tribes
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44054
Semantic_Type: Population Group
Preferred_Name: Northwest Tribes
UMLS_CUI: C1551439
Legacy_Concept_Name: Northwest_Tribes
has exact synonym: Northwest Tribes

Alsea
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44055
Semantic_Type: Population Group
Preferred_Name: Alsea
UMLS_CUI: C1551440
Legacy_Concept_Name: Alsea
has exact synonym: Alsea

Celilo
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44056
Semantic_Type: Population Group
Preferred_Name: Celilo
UMLS_CUI: C1551441
Legacy_Concept_Name: Celilo
has exact synonym: Celilo

Columbia
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44057
Semantic_Type: Population Group
Preferred_Name: Columbia
UMLS_CUI: C1551442
Legacy_Concept_Name: Columbia_Indian
has exact synonym: Columbia

Kalapuya
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44058
Semantic_Type: Population Group
Preferred_Name: Kalapuya
UMLS_CUI: C1551443
Legacy_Concept_Name: Kalapuya
has exact synonym: Kalapuya

Molala
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44059
Semantic_Type: Population Group
Preferred_Name: Molala
UMLS_CUI: C1551444
Legacy_Concept_Name: Molala
has exact synonym: Molala

Talakamish
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44060
Semantic_Type: Population Group
Preferred_Name: Talakamish
UMLS_CUI: C1551445
Legacy_Concept_Name: Talakamish
has exact synonym: Talakamish

Tenino
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44061
Semantic_Type: Population Group
Preferred_Name: Tenino
UMLS_CUI: C1551446
Legacy_Concept_Name: Tenino
has exact synonym: Tenino

Tillamook
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44062
Semantic_Type: Population Group
Preferred_Name: Tillamook
UMLS_CUI: C1551447
Legacy_Concept_Name: Tillamook
has exact synonym: Tillamook

Wenatchee
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44063
Semantic_Type: Population Group
Preferred_Name: Wenatchee
UMLS_CUI: C1551448
Legacy_Concept_Name: Wenatchee
has exact synonym: Wenatchee

Yahooskin
type: Class
subclass of: Northwest Tribes
imported from: ncit.owl
code: C44064
Semantic_Type: Population Group
Preferred_Name: Yahooskin
UMLS_CUI: C1551449
Legacy_Concept_Name: Yahooskin
has exact synonym: Yahooskin

Omaha
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44065
Semantic_Type: Population Group
Preferred_Name: Omaha
UMLS_CUI: C1551450
Legacy_Concept_Name: Omaha
has exact synonym: Omaha

Oregon Athabaskan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44066
Semantic_Type: Population Group
Preferred_Name: Oregon Athabaskan
UMLS_CUI: C1551451
Legacy_Concept_Name: Oregon_Athabaskan
has exact synonym: Oregon Athabaskan

Osage
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44067
Semantic_Type: Population Group
Preferred_Name: Osage
UMLS_CUI: C1551452
Legacy_Concept_Name: Osage
has exact synonym: Osage

Otoe-Missouria
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44068
Semantic_Type: Population Group
Preferred_Name: Otoe-Missouria
UMLS_CUI: C1551453
Legacy_Concept_Name: Otoe_Missouria
has exact synonym: Otoe-Missouria

Ottawa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44069
Semantic_Type: Population Group
Preferred_Name: Ottawa
UMLS_CUI: C1551454
Legacy_Concept_Name: Ottawa
has exact synonym: Ottawa

Burt Lake Ottawa
type: Class
subclass of: Ottawa
imported from: ncit.owl
code: C44070
Semantic_Type: Population Group
Preferred_Name: Burt Lake Ottawa
UMLS_CUI: C1551455
Legacy_Concept_Name: Burt_Lake_Ottawa
has exact synonym: Burt Lake Ottawa

Michigan Ottawa
type: Class
subclass of: Ottawa
imported from: ncit.owl
code: C44071
Semantic_Type: Population Group
Preferred_Name: Michigan Ottawa
UMLS_CUI: C1551456
Legacy_Concept_Name: Michigan_Ottawa
has exact synonym: Michigan Ottawa

Oklahoma Ottawa
type: Class
subclass of: Ottawa
imported from: ncit.owl
code: C44072
Semantic_Type: Population Group
Preferred_Name: Oklahoma Ottawa
UMLS_CUI: C1551457
Legacy_Concept_Name: Oklahoma_Ottawa
has exact synonym: Oklahoma Ottawa

Paiute
type: Class
subclass of: Shoshone Paiute
imported from: ncit.owl
code: C44073
Semantic_Type: Population Group
Preferred_Name: Paiute
UMLS_CUI: C0682113
Legacy_Concept_Name: Paiute
has exact synonym: Paiute

Pamunkey
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44074
Semantic_Type: Population Group
Preferred_Name: Pamunkey
UMLS_CUI: C1551479
Legacy_Concept_Name: Pamunkey
has exact synonym: Pamunkey

Passamaquoddy
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44075
Semantic_Type: Population Group
Preferred_Name: Passamaquoddy
UMLS_CUI: C1551480
Legacy_Concept_Name: Passamaquoddy
has exact synonym: Passamaquoddy

Indian Township
type: Class
subclass of: Passamaquoddy
imported from: ncit.owl
code: C44076
Semantic_Type: Population Group
Preferred_Name: Indian Township
UMLS_CUI: C1551481
Legacy_Concept_Name: Indian_Township
has exact synonym: Indian Township

Pleasant Point Passamaquoddy
type: Class
subclass of: Passamaquoddy
imported from: ncit.owl
code: C44077
Semantic_Type: Population Group
Preferred_Name: Pleasant Point Passamaquoddy
UMLS_CUI: C1551482
Legacy_Concept_Name: Pleasant_Point_Passamaquoddy
has exact synonym: Pleasant Point Passamaquoddy

Pawnee
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44078
Semantic_Type: Population Group
Preferred_Name: Pawnee
UMLS_CUI: C0682108
Legacy_Concept_Name: Pawnee
has exact synonym: Pawnee

Oklahoma Pawnee
type: Class
subclass of: Pawnee
imported from: ncit.owl
code: C44079
Semantic_Type: Population Group
Preferred_Name: Oklahoma Pawnee
UMLS_CUI: C1551483
Legacy_Concept_Name: Oklahoma_Pawnee
has exact synonym: Oklahoma Pawnee

Penobscot
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44080
Semantic_Type: Population Group
Preferred_Name: Penobscot
UMLS_CUI: C0682097
Legacy_Concept_Name: Penobscot
has exact synonym: Penobscot

Peoria
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44081
Semantic_Type: Population Group
Preferred_Name: Peoria
UMLS_CUI: C1551484
Legacy_Concept_Name: Peoria
has exact synonym: Peoria

Oklahoma Peoria
type: Class
subclass of: Peoria
imported from: ncit.owl
code: C44082
Semantic_Type: Population Group
Preferred_Name: Oklahoma Peoria
UMLS_CUI: C1551485
Legacy_Concept_Name: Oklahoma_Peoria
has exact synonym: Oklahoma Peoria

Pequot
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44083
Semantic_Type: Population Group
Preferred_Name: Pequot
UMLS_CUI: C1551486
Legacy_Concept_Name: Pequot
has exact synonym: Pequot

Marshantucket Pequot
type: Class
subclass of: Pequot
imported from: ncit.owl
code: C44084
Semantic_Type: Population Group
Preferred_Name: Marshantucket Pequot
UMLS_CUI: C1551487
Legacy_Concept_Name: Marshantucket_Pequot
has exact synonym: Marshantucket Pequot

Pima
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44085
Semantic_Type: Population Group
Preferred_Name: Pima
UMLS_CUI: C1551488
Legacy_Concept_Name: Pima
has exact synonym: Pima

Gila River Pima-Maricopa
type: Class
subclass of: Pima
imported from: ncit.owl
code: C44086
Semantic_Type: Population Group
Preferred_Name: Gila River Pima-Maricopa
UMLS_CUI: C1551489
Legacy_Concept_Name: Gila_River_Pima_Maricopa
has exact synonym: Gila River Pima-Maricopa

Salt River Pima-Maricopa
type: Class
subclass of: Pima
imported from: ncit.owl
code: C44087
Semantic_Type: Population Group
Preferred_Name: Salt River Pima-Maricopa
UMLS_CUI: C1551490
Legacy_Concept_Name: Salt_River_Pima_Maricopa
has exact synonym: Salt River Pima-Maricopa

Piscataway
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44088
Semantic_Type: Population Group
Preferred_Name: Piscataway
UMLS_CUI: C1551491
Legacy_Concept_Name: Piscataway
has exact synonym: Piscataway

Pit River
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44089
Semantic_Type: Population Group
Preferred_Name: Pit River
UMLS_CUI: C1551492
Legacy_Concept_Name: Pit_River
has exact synonym: Pit River

Pomo
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44090
Semantic_Type: Population Group
Preferred_Name: Pomo
UMLS_CUI: C1551493
Legacy_Concept_Name: Pomo
has exact synonym: Pomo

Ponca
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44091
Semantic_Type: Population Group
Preferred_Name: Ponca
UMLS_CUI: C1551502
Legacy_Concept_Name: Ponca
has exact synonym: Ponca

Nebraska Ponca
type: Class
subclass of: Ponca
imported from: ncit.owl
code: C44092
Semantic_Type: Population Group
Preferred_Name: Nebraska Ponca
UMLS_CUI: C1551503
Legacy_Concept_Name: Nebraska_Ponca
has exact synonym: Nebraska Ponca

Oklahoma Ponca
type: Class
subclass of: Ponca
imported from: ncit.owl
code: C44093
Semantic_Type: Population Group
Preferred_Name: Oklahoma Ponca
UMLS_CUI: C1551504
Legacy_Concept_Name: Oklahoma_Ponca
has exact synonym: Oklahoma Ponca

Potawatomi
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44094
Semantic_Type: Population Group
Preferred_Name: Potawatomi
UMLS_CUI: C1551505
Legacy_Concept_Name: Potawatomi
has exact synonym: Potawatomi

Powhatan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44095
Semantic_Type: Population Group
Preferred_Name: Powhatan
UMLS_CUI: C1551513
Legacy_Concept_Name: Powhatan
has exact synonym: Powhatan

Pueblo
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44096
Semantic_Type: Population Group
Preferred_Name: Pueblo
UMLS_CUI: C1556090
Legacy_Concept_Name: Pueblo
has exact synonym: Pueblo

Puget Sound Salish
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44102
Semantic_Type: Population Group
Preferred_Name: Puget Sound Salish
UMLS_CUI: C1551539
Legacy_Concept_Name: Puget_Sound_Salish
has exact synonym: Puget Sound Salish

Quapaw
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44103
Semantic_Type: Population Group
Preferred_Name: Quapaw
UMLS_CUI: C1551561
Legacy_Concept_Name: Quapaw
has exact synonym: Quapaw

Quinault
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44104
Semantic_Type: Population Group
Preferred_Name: Quinault
UMLS_CUI: C1551562
Legacy_Concept_Name: Quinault
has exact synonym: Quinault

Rappahannock
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44105
Semantic_Type: Population Group
Preferred_Name: Rappahannock
UMLS_CUI: C1551563
Legacy_Concept_Name: Rappahannock
has exact synonym: Rappahannock

Reno-Sparks
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44106
Semantic_Type: Population Group
Preferred_Name: Reno-Sparks
UMLS_CUI: C1551564
Legacy_Concept_Name: Reno_Sparks
has exact synonym: Reno-Sparks

Round Valley
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44107
Semantic_Type: Population Group
Preferred_Name: Round Valley
UMLS_CUI: C1551565
Legacy_Concept_Name: Round_Valley
has exact synonym: Round Valley

Sac and Fox
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44108
Semantic_Type: Population Group
Preferred_Name: Sac and Fox
UMLS_CUI: C1551566
Legacy_Concept_Name: Sac_and_Fox
has exact synonym: Sac and Fox

Iowa Sac and Fox
type: Class
subclass of: Sac and Fox
imported from: ncit.owl
code: C44109
Semantic_Type: Population Group
Preferred_Name: Iowa Sac and Fox
UMLS_CUI: C1551567
Legacy_Concept_Name: Iowa_Sac_and_Fox
has exact synonym: Iowa Sac and Fox

Missouri Sac and Fox
type: Class
subclass of: Sac and Fox
imported from: ncit.owl
code: C44110
Semantic_Type: Population Group
Preferred_Name: Missouri Sac and Fox
UMLS_CUI: C1551568
Legacy_Concept_Name: Missouri_Sac_and_Fox
has exact synonym: Missouri Sac and Fox

Oklahoma Sac and Fox
type: Class
subclass of: Sac and Fox
imported from: ncit.owl
code: C44111
Semantic_Type: Population Group
Preferred_Name: Oklahoma Sac and Fox
UMLS_CUI: C1551569
Legacy_Concept_Name: Oklahoma_Sac_and_Fox
has exact synonym: Oklahoma Sac and Fox

Salinan
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44112
Semantic_Type: Population Group
Preferred_Name: Salinan
UMLS_CUI: C1551570
Legacy_Concept_Name: Salinan
has exact synonym: Salinan

Salish
type: Class
subclass of: Salish and Kootenai
imported from: ncit.owl
code: C44113
Semantic_Type: Population Group
Preferred_Name: Salish
UMLS_CUI: C1551571
Legacy_Concept_Name: Salish
has exact synonym: Salish

Salish and Kootenai
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44114
Semantic_Type: Population Group
Preferred_Name: Salish and Kootenai
UMLS_CUI: C1551572
Legacy_Concept_Name: Salish_and_Kootenai
has exact synonym: Salish and Kootenai

Schaghticoke
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44115
Semantic_Type: Population Group
Preferred_Name: Schaghticoke
UMLS_CUI: C1551573
Legacy_Concept_Name: Schaghticoke
has exact synonym: Schaghticoke

Scott Valley
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44116
Semantic_Type: Population Group
Preferred_Name: Scott Valley
UMLS_CUI: C1551574
Legacy_Concept_Name: Scott_Valley
has exact synonym: Scott Valley

Seminole
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44117
Semantic_Type: Population Group
Preferred_Name: Seminole
UMLS_CUI: C1556091
Legacy_Concept_Name: Seminole
has exact synonym: Seminole

Big Cypress
type: Class
subclass of: Seminole
imported from: ncit.owl
code: C44118
Semantic_Type: Population Group
Preferred_Name: Big Cypress
UMLS_CUI: C1551575
Legacy_Concept_Name: Big_Cypress
has exact synonym: Big Cypress

Brighton
type: Class
subclass of: Seminole
imported from: ncit.owl
code: C44119
Semantic_Type: Population Group
Preferred_Name: Brighton
UMLS_CUI: C1551576
Legacy_Concept_Name: Brighton
has exact synonym: Brighton

Florida Seminole
type: Class
subclass of: Seminole
imported from: ncit.owl
code: C44120
Semantic_Type: Population Group
Preferred_Name: Florida Seminole
UMLS_CUI: C1551577
Legacy_Concept_Name: Florida_Seminole
has exact synonym: Florida Seminole

Hollywood Seminole
type: Class
subclass of: Seminole
imported from: ncit.owl
code: C44121
Semantic_Type: Population Group
Preferred_Name: Hollywood Seminole
UMLS_CUI: C1551578
Legacy_Concept_Name: Hollywood_Seminole
has exact synonym: Hollywood Seminole

Oklahoma Seminole
type: Class
subclass of: Seminole
imported from: ncit.owl
code: C44122
Semantic_Type: Population Group
Preferred_Name: Oklahoma Seminole
UMLS_CUI: C1551579
Legacy_Concept_Name: Oklahoma_Seminole
has exact synonym: Oklahoma Seminole

Serrano
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44123
Semantic_Type: Population Group
Preferred_Name: Serrano
UMLS_CUI: C1551580
Legacy_Concept_Name: Serrano
has exact synonym: Serrano

San Manual
type: Class
subclass of: Serrano
imported from: ncit.owl
code: C44124
Semantic_Type: Population Group
Preferred_Name: San Manual
UMLS_CUI: C1551581
Legacy_Concept_Name: San_Manual
has exact synonym: San Manual

Shasta
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44125
Semantic_Type: Population Group
Preferred_Name: Shasta
UMLS_CUI: C1551582
Legacy_Concept_Name: Shasta
has exact synonym: Shasta

Shawnee
type: Class
subclass of: Cherokee Shawnee
imported from: ncit.owl
code: C44126
Semantic_Type: Population Group
Preferred_Name: Shawnee
UMLS_CUI: C1551583
Legacy_Concept_Name: Shawnee
has exact synonym: Shawnee

Absentee Shawnee
type: Class
subclass of: Shawnee
imported from: ncit.owl
code: C44127
Semantic_Type: Population Group
Preferred_Name: Absentee Shawnee
UMLS_CUI: C1551584
Legacy_Concept_Name: Absentee_Shawnee
has exact synonym: Absentee Shawnee

Eastern Shawnee
type: Class
subclass of: Shawnee
imported from: ncit.owl
code: C44128
Semantic_Type: Population Group
Preferred_Name: Eastern Shawnee
UMLS_CUI: C1551585
Legacy_Concept_Name: Eastern_Shawnee
has exact synonym: Eastern Shawnee

Shinnecock
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44129
Semantic_Type: Population Group
Preferred_Name: Shinnecock
UMLS_CUI: C1551586
Legacy_Concept_Name: Shinnecock
has exact synonym: Shinnecock

Shoalwater Bay
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44130
Semantic_Type: Population Group
Preferred_Name: Shoalwater Bay
UMLS_CUI: C1551587
Legacy_Concept_Name: Shoalwater_Bay
has exact synonym: Shoalwater Bay

Shoshone
type: Class
subclass of: Shoshone Paiute
imported from: ncit.owl
code: C44131
Semantic_Type: Population Group
Preferred_Name: Shoshone
UMLS_CUI: C0337886
Legacy_Concept_Name: Shoshone
has exact synonym: Shoshone

Shoshone Paiute
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44132
Semantic_Type: Population Group
Preferred_Name: Shoshone Paiute
UMLS_CUI: C1551602
Legacy_Concept_Name: Shoshone_Paiute
has exact synonym: Shoshone Paiute

Duck Valley
type: Class
subclass of: Shoshone Paiute
imported from: ncit.owl
code: C44133
Semantic_Type: Population Group
Preferred_Name: Duck Valley
UMLS_CUI: C1551603
Legacy_Concept_Name: Duck_Valley
has exact synonym: Duck Valley

Fallon
type: Class
subclass of: Shoshone Paiute
imported from: ncit.owl
code: C44134
Semantic_Type: Population Group
Preferred_Name: Fallon
UMLS_CUI: C1551604
Legacy_Concept_Name: Fallon
has exact synonym: Fallon

Fort McDermitt
type: Class
subclass of: Shoshone Paiute
imported from: ncit.owl
code: C44135
Semantic_Type: Population Group
Preferred_Name: Fort McDermitt
UMLS_CUI: C1551605
Legacy_Concept_Name: Fort_McDermitt
has exact synonym: Fort McDermitt

Siletz
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44136
Semantic_Type: Population Group
Preferred_Name: Siletz
UMLS_CUI: C1551606
Legacy_Concept_Name: Siletz
has exact synonym: Siletz

Sioux
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44137
Semantic_Type: Population Group
Preferred_Name: Sioux
UMLS_CUI: C0682107
Legacy_Concept_Name: Sioux
has exact synonym: Sioux

Blackfoot Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44138
Semantic_Type: Population Group
Preferred_Name: Blackfoot Sioux
UMLS_CUI: C1551607
Legacy_Concept_Name: Blackfoot_Sioux
has exact synonym: Blackfoot Sioux

Brule Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44139
Semantic_Type: Population Group
Preferred_Name: Brule Sioux
UMLS_CUI: C1551608
Legacy_Concept_Name: Brule_Sioux
has exact synonym: Brule Sioux

Cheyenne River Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44140
Semantic_Type: Population Group
Preferred_Name: Cheyenne River Sioux
UMLS_CUI: C1551609
Legacy_Concept_Name: Cheyenne_River_Sioux
has exact synonym: Cheyenne River Sioux

Lakota
type: Class
subclass of: Sioux
imported from: ncit.owl
code: C44141
Semantic_Type: Population Group
Preferred_Name: Lakota
UMLS_CUI: C1551631
Legacy_Concept_Name: Lakota
has exact synonym: Lakota
has exact synonym: Lakota Sioux
has exact synonym: Teton Sioux

Dakota
type: Class
subclass of: Sioux
imported from: ncit.owl
code: C44142
Semantic_Type: Population Group
Preferred_Name: Dakota
UMLS_CUI: C1551611
Legacy_Concept_Name: Dakota
has exact synonym: Dakota
has exact synonym: Dakota Sioux

Nakota
type: Class
subclass of: Sioux
imported from: ncit.owl
code: C44143
Semantic_Type: Population Group
Preferred_Name: Nakota
NCI_META_CUI: CL448673
Legacy_Concept_Name: Nakota
has exact synonym: Nakota
has exact synonym: Nakota Sioux

Crow Creek Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44144
Semantic_Type: Population Group
Preferred_Name: Crow Creek Sioux
UMLS_CUI: C1551610
Legacy_Concept_Name: Crow_Creek_Sioux
has exact synonym: Crow Creek Sioux

Flandreau Santee
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44145
Semantic_Type: Population Group
Preferred_Name: Flandreau Santee
UMLS_CUI: C1551612
Legacy_Concept_Name: Flandreau_Santee
has exact synonym: Flandreau Santee

Lake Traverse Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44146
Semantic_Type: Population Group
Preferred_Name: Lake Traverse Sioux
UMLS_CUI: C1551614
Legacy_Concept_Name: Lake_Traverse_Sioux
has exact synonym: Lake Traverse Sioux

Fort Peck Sioux
type: Class
subclass of: Nakota
imported from: ncit.owl
code: C44147
Semantic_Type: Population Group
Preferred_Name: Fort Peck Sioux
UMLS_CUI: C1551613
Legacy_Concept_Name: Fort_Peck_Sioux
has exact synonym: Fort Peck
has exact synonym: Fort Peck Sioux

Lower Brule Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44148
Semantic_Type: Population Group
Preferred_Name: Lower Brule Sioux
UMLS_CUI: C1551615
Legacy_Concept_Name: Lower_Brule_Sioux
has exact synonym: Lower Brule Sioux

Lower Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44149
Semantic_Type: Population Group
Preferred_Name: Lower Sioux
UMLS_CUI: C1551616
Legacy_Concept_Name: Lower_Sioux
has exact synonym: Lower Sioux

Mdewakanton Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44150
Semantic_Type: Population Group
Preferred_Name: Mdewakanton Sioux
UMLS_CUI: C1551617
Legacy_Concept_Name: Mdewakanton_Sioux
has exact synonym: Mdewakanton Sioux

Miniconjou
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44151
Semantic_Type: Population Group
Preferred_Name: Miniconjou
UMLS_CUI: C1551618
Legacy_Concept_Name: Miniconjou
has exact synonym: Miniconjou

Oglala Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44152
Semantic_Type: Population Group
Preferred_Name: Oglala Sioux
UMLS_CUI: C1551619
Legacy_Concept_Name: Oglala_Sioux
has exact synonym: Oglala Sioux

Pine Ridge Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44153
Semantic_Type: Population Group
Preferred_Name: Pine Ridge Sioux
UMLS_CUI: C1551620
Legacy_Concept_Name: Pine_Ridge_Sioux
has exact synonym: Pine Ridge Sioux

Pipestone Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44154
Semantic_Type: Population Group
Preferred_Name: Pipestone Sioux
UMLS_CUI: C1551621
Legacy_Concept_Name: Pipestone_Sioux
has exact synonym: Pipestone Sioux

Prairie Island Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44155
Semantic_Type: Population Group
Preferred_Name: Prairie Island Sioux
UMLS_CUI: C1551622
Legacy_Concept_Name: Prairie_Island_Sioux
has exact synonym: Prairie Island Sioux

Prior Lake Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44156
Semantic_Type: Population Group
Preferred_Name: Prior Lake Sioux
UMLS_CUI: C1551623
Legacy_Concept_Name: Prior_Lake_Sioux
has exact synonym: Prior Lake Sioux

Rosebud Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44157
Semantic_Type: Population Group
Preferred_Name: Rosebud Sioux
UMLS_CUI: C1551624
Legacy_Concept_Name: Rosebud_Sioux
has exact synonym: Rosebud Sioux

Sans Arc Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44158
Semantic_Type: Population Group
Preferred_Name: Sans Arc Sioux
UMLS_CUI: C1551625
Legacy_Concept_Name: Sans_Arc_Sioux
has exact synonym: Sans Arc Sioux

Santee Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44159
Semantic_Type: Population Group
Preferred_Name: Santee Sioux
UMLS_CUI: C1551626
Legacy_Concept_Name: Santee_Sioux
has exact synonym: Santee Sioux

Sisseton-Wahpeton
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44160
Semantic_Type: Population Group
Preferred_Name: Sisseton-Wahpeton
UMLS_CUI: C1551627
Legacy_Concept_Name: Sisseton_Wahpeton
has exact synonym: Sisseton-Wahpeton

Sisseton Sioux
type: Class
subclass of: Sisseton-Wahpeton
imported from: ncit.owl
code: C44161
Semantic_Type: Population Group
Preferred_Name: Sisseton Sioux
UMLS_CUI: C1551628
Legacy_Concept_Name: Sisseton_Sioux
has exact synonym: Sisseton Sioux

Wahpeton Sioux
type: Class
subclass of: Sisseton-Wahpeton
imported from: ncit.owl
code: C44162
Semantic_Type: Population Group
Preferred_Name: Wahpeton Sioux
UMLS_CUI: C1551635
Legacy_Concept_Name: Wahpeton_Sioux
has exact synonym: Wahpeton Sioux

Spirit Lake Sioux
type: Class
subclass of: Nakota
imported from: ncit.owl
code: C44163
Semantic_Type: Population Group
Preferred_Name: Spirit Lake Sioux
UMLS_CUI: C1551629
Legacy_Concept_Name: Spirit_Lake_Sioux
has exact synonym: Spirit Lake Sioux

Standing Rock Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44164
Semantic_Type: Population Group
Preferred_Name: Standing Rock Sioux
UMLS_CUI: C1551630
Legacy_Concept_Name: Standing_Rock_Sioux
has exact synonym: Standing Rock Sioux

Two Kettle Sioux
type: Class
subclass of: Lakota
imported from: ncit.owl
code: C44165
Semantic_Type: Population Group
Preferred_Name: Two Kettle Sioux
UMLS_CUI: C1551632
Legacy_Concept_Name: Two_Kettle_Sioux
has exact synonym: Two Kettle Sioux

Upper Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44187
Semantic_Type: Population Group
Preferred_Name: Upper Sioux
UMLS_CUI: C1551633
Legacy_Concept_Name: Upper_Sioux
has exact synonym: Upper Sioux

Wahpekute Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44188
Semantic_Type: Population Group
Preferred_Name: Wahpekute Sioux
UMLS_CUI: C1551634
Legacy_Concept_Name: Wahpekute_Sioux
has exact synonym: Wahpekute Sioux

Wazhaza Sioux
type: Class
subclass of: Dakota
imported from: ncit.owl
code: C44189
Semantic_Type: Population Group
Preferred_Name: Wazhaza Sioux
UMLS_CUI: C1551636
Legacy_Concept_Name: Wazhaza_Sioux
has exact synonym: Wazhaza Sioux

Yankton Sioux
type: Class
subclass of: Nakota
imported from: ncit.owl
code: C44190
Semantic_Type: Population Group
Preferred_Name: Yankton Sioux
UMLS_CUI: C1551637
Legacy_Concept_Name: Yankton_Sioux
has exact synonym: Yankton Sioux

Yanktonai Sioux
type: Class
subclass of: Nakota
imported from: ncit.owl
code: C44191
Semantic_Type: Population Group
Preferred_Name: Yanktonai Sioux
UMLS_CUI: C1551638
Legacy_Concept_Name: Yanktonai_Sioux
has exact synonym: Yanktonai Sioux

Siuslaw
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44192
Semantic_Type: Population Group
Preferred_Name: Siuslaw
UMLS_CUI: C1551639
Legacy_Concept_Name: Siuslaw
has exact synonym: Siuslaw

Spokane
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44193
Semantic_Type: Population Group
Preferred_Name: Spokane
UMLS_CUI: C1551640
Legacy_Concept_Name: Spokane
has exact synonym: Spokane

Stewart
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44194
Semantic_Type: Population Group
Preferred_Name: Stewart
UMLS_CUI: C1551641
Legacy_Concept_Name: Stewart
has exact synonym: Stewart

Stockbridge
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44195
Semantic_Type: Population Group
Preferred_Name: Stockbridge
UMLS_CUI: C1551642
Legacy_Concept_Name: Stockbridge
has exact synonym: Stockbridge

Susanville
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44196
Semantic_Type: Population Group
Preferred_Name: Susanville
UMLS_CUI: C1551643
Legacy_Concept_Name: Susanville
has exact synonym: Susanville

Tohono O'Odham
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44197
Semantic_Type: Population Group
Preferred_Name: Tohono O'Odham
UMLS_CUI: C1551644
Legacy_Concept_Name: Tohono_O_Odham
has exact synonym: Tohono O'Odham

Ak-Chin
type: Class
subclass of: Tohono O'Odham
imported from: ncit.owl
code: C44198
Semantic_Type: Population Group
Preferred_Name: Ak-Chin
UMLS_CUI: C1551645
Legacy_Concept_Name: Ak_Chin
has exact synonym: Ak-Chin

Gila Bend
type: Class
subclass of: Tohono O'Odham
imported from: ncit.owl
code: C44199
Semantic_Type: Population Group
Preferred_Name: Gila Bend
UMLS_CUI: C1551646
Legacy_Concept_Name: Gila_Bend
has exact synonym: Gila Bend

San Xavier
type: Class
subclass of: Tohono O'Odham
imported from: ncit.owl
code: C44200
Semantic_Type: Population Group
Preferred_Name: San Xavier
UMLS_CUI: C1551647
Legacy_Concept_Name: San_Xavier
has exact synonym: San Xavier

Sells
type: Class
subclass of: Tohono O'Odham
imported from: ncit.owl
code: C44201
Semantic_Type: Population Group
Preferred_Name: Sells
UMLS_CUI: C1551648
Legacy_Concept_Name: Sells
has exact synonym: Sells

Tolowa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44202
Semantic_Type: Population Group
Preferred_Name: Tolowa
UMLS_CUI: C1551649
Legacy_Concept_Name: Tolowa
has exact synonym: Tolowa

Tonkawa
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44203
Semantic_Type: Population Group
Preferred_Name: Tonkawa
UMLS_CUI: C1551650
Legacy_Concept_Name: Tonkawa
has exact synonym: Tonkawa

Tygh
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44204
Semantic_Type: Population Group
Preferred_Name: Tygh
UMLS_CUI: C1551651
Legacy_Concept_Name: Tygh
has exact synonym: Tygh

Umatilla
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44205
Semantic_Type: Population Group
Preferred_Name: Umatilla
UMLS_CUI: C1551652
Legacy_Concept_Name: Umatilla
has exact synonym: Umatilla

Umpqua
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44206
Semantic_Type: Population Group
Preferred_Name: Umpqua
UMLS_CUI: C1551653
Legacy_Concept_Name: Umpqua
has exact synonym: Umpqua

Cow Creek Umpqua
type: Class
subclass of: Umpqua
imported from: ncit.owl
code: C44207
Semantic_Type: Population Group
Preferred_Name: Cow Creek Umpqua
UMLS_CUI: C1551654
Legacy_Concept_Name: Cow_Creek_Umpqua
has exact synonym: Cow Creek Umpqua

Ute
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44208
Semantic_Type: Population Group
Preferred_Name: Ute
UMLS_CUI: C1556092
Legacy_Concept_Name: Ute
has exact synonym: Ute

Allen Canyon
type: Class
subclass of: Ute
imported from: ncit.owl
code: C44209
Semantic_Type: Population Group
Preferred_Name: Allen Canyon
UMLS_CUI: C1551655
Legacy_Concept_Name: Allen_Canyon
has exact synonym: Allen Canyon

Uintah Ute
type: Class
subclass of: Ute
imported from: ncit.owl
code: C44210
Semantic_Type: Population Group
Preferred_Name: Uintah Ute
UMLS_CUI: C1551656
Legacy_Concept_Name: Uintah_Ute
has exact synonym: Uintah Ute

Ute Mountain Ute
type: Class
subclass of: Ute
imported from: ncit.owl
code: C44211
Semantic_Type: Population Group
Preferred_Name: Ute Mountain Ute
UMLS_CUI: C1551657
Legacy_Concept_Name: Ute_Mountain_Ute
has exact synonym: Ute Mountain Ute

Wailaki
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44212
Semantic_Type: Population Group
Preferred_Name: Wailaki
UMLS_CUI: C1551658
Legacy_Concept_Name: Wailaki
has exact synonym: Wailaki

Walla-Walla
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44213
Semantic_Type: Population Group
Preferred_Name: Walla-Walla
UMLS_CUI: C1551659
Legacy_Concept_Name: Walla_Walla
has exact synonym: Walla-Walla

Wampanoag
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44214
Semantic_Type: Population Group
Preferred_Name: Wampanoag
UMLS_CUI: C1551660
Legacy_Concept_Name: Wampanoag
has exact synonym: Wampanoag

Gay Head Wampanoag
type: Class
subclass of: Wampanoag
imported from: ncit.owl
code: C44215
Semantic_Type: Population Group
Preferred_Name: Gay Head Wampanoag
UMLS_CUI: C1551661
Legacy_Concept_Name: Gay_Head_Wampanoag
has exact synonym: Gay Head Wampanoag

Mashpee Wampanoag
type: Class
subclass of: Wampanoag
imported from: ncit.owl
code: C44216
Semantic_Type: Population Group
Preferred_Name: Mashpee Wampanoag
UMLS_CUI: C1551662
Legacy_Concept_Name: Mashpee_Wampanoag
has exact synonym: Mashpee Wampanoag

Warm Springs
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44217
Semantic_Type: Population Group
Preferred_Name: Warm Springs
UMLS_CUI: C1551663
Legacy_Concept_Name: Warm_Springs
has exact synonym: Warm Springs

Wascopum
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44218
Semantic_Type: Population Group
Preferred_Name: Wascopum
UMLS_CUI: C1551664
Legacy_Concept_Name: Wascopum
has exact synonym: Wascopum

Washoe
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44219
Semantic_Type: Population Group
Preferred_Name: Washoe
UMLS_CUI: C1551665
Legacy_Concept_Name: Washoe
has exact synonym: Washoe

Alpine
type: Class
subclass of: Washoe
imported from: ncit.owl
code: C44220
Semantic_Type: Population Group
Preferred_Name: Alpine
UMLS_CUI: C1551666
Legacy_Concept_Name: Alpine
has exact synonym: Alpine

Carson
type: Class
subclass of: Washoe
imported from: ncit.owl
code: C44221
Semantic_Type: Population Group
Preferred_Name: Carson
UMLS_CUI: C1551667
Legacy_Concept_Name: Carson
has exact synonym: Carson

Dresslerville
type: Class
subclass of: Washoe
imported from: ncit.owl
code: C44222
Semantic_Type: Population Group
Preferred_Name: Dresslerville
UMLS_CUI: C1551668
Legacy_Concept_Name: Dresslerville
has exact synonym: Dresslerville

Wichita
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44223
Semantic_Type: Population Group
Preferred_Name: Wichita
UMLS_CUI: C1551669
Legacy_Concept_Name: Wichita
has exact synonym: Wichita

Wind River
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44224
Semantic_Type: Population Group
Preferred_Name: Wind River
UMLS_CUI: C1551670
Legacy_Concept_Name: Wind_River
has exact synonym: Wind River

Winnebago
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44225
Semantic_Type: Population Group
Preferred_Name: Winnebago
UMLS_CUI: C1551671
Legacy_Concept_Name: Winnebago
has exact synonym: Winnebago

Ho-Chunk
type: Class
subclass of: Winnebago
imported from: ncit.owl
code: C44226
Semantic_Type: Population Group
Preferred_Name: Ho-Chunk
UMLS_CUI: C1551672
Legacy_Concept_Name: Ho_Chunk
has exact synonym: Ho-Chunk

Nebraska Winnebago
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44227
Semantic_Type: Population Group
Preferred_Name: Nebraska Winnebago
UMLS_CUI: C1551673
Legacy_Concept_Name: Nebraska_Winnebago
has exact synonym: Nebraska Winnebago

Winnemucca
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44228
Semantic_Type: Population Group
Preferred_Name: Winnemucca
UMLS_CUI: C1551674
Legacy_Concept_Name: Winnemucca
has exact synonym: Winnemucca

Wintun
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44229
Semantic_Type: Population Group
Preferred_Name: Wintun
UMLS_CUI: C1551675
Legacy_Concept_Name: Wintun
has exact synonym: Wintun

Wiyot
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44230
Semantic_Type: Population Group
Preferred_Name: Wiyot
UMLS_CUI: C1551676
Legacy_Concept_Name: Wiyot
has exact synonym: Wiyot

Table Bluff
type: Class
subclass of: Wiyot
imported from: ncit.owl
code: C44231
Semantic_Type: Population Group
Preferred_Name: Table Bluff
UMLS_CUI: C1551677
Legacy_Concept_Name: Table_Bluff
has exact synonym: Table Bluff

Yakama
type: Class
subclass of: Yakama Cowlitz
imported from: ncit.owl
code: C44232
Semantic_Type: Population Group
Preferred_Name: Yakama
UMLS_CUI: C1551678
Legacy_Concept_Name: Yakama
has exact synonym: Yakama

Yakama Cowlitz
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44233
Semantic_Type: Population Group
Preferred_Name: Yakama Cowlitz
UMLS_CUI: C1551679
Legacy_Concept_Name: Yakama_Cowlitz
has exact synonym: Yakama Cowlitz

Yaqui
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44234
Semantic_Type: Population Group
Preferred_Name: Yaqui
UMLS_CUI: C1551680
Legacy_Concept_Name: Yaqui
has exact synonym: Yaqui

Barrio Libre
type: Class
subclass of: Yaqui
imported from: ncit.owl
code: C44236
Semantic_Type: Population Group
Preferred_Name: Barrio Libre
UMLS_CUI: C1551681
Legacy_Concept_Name: Barrio_Libre
has exact synonym: Barrio Libre

Pascua Yaqui
type: Class
subclass of: Yaqui
imported from: ncit.owl
code: C44237
Semantic_Type: Population Group
Preferred_Name: Pascua Yaqui
UMLS_CUI: C1551682
Legacy_Concept_Name: Pascua_Yaqui
has exact synonym: Pascua Yaqui

Yavapai Apache
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44238
Semantic_Type: Population Group
Preferred_Name: Yavapai Apache
UMLS_CUI: C1551683
Legacy_Concept_Name: Yavapai_Apache
has exact synonym: Yavapai Apache

Yokuts
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44239
Semantic_Type: Population Group
Preferred_Name: Yokuts
UMLS_CUI: C1551684
Legacy_Concept_Name: Yokuts
has exact synonym: Yokuts

Chukchansi
type: Class
subclass of: Yokuts
imported from: ncit.owl
code: C44240
Semantic_Type: Population Group
Preferred_Name: Chukchansi
UMLS_CUI: C1551685
Legacy_Concept_Name: Chukchansi
has exact synonym: Chukchansi

Tachi
type: Class
subclass of: Yokuts
imported from: ncit.owl
code: C44241
Semantic_Type: Population Group
Preferred_Name: Tachi
UMLS_CUI: C1551686
Legacy_Concept_Name: Tachi
has exact synonym: Tachi

Tule River
type: Class
subclass of: Yokuts
imported from: ncit.owl
code: C44242
Semantic_Type: Population Group
Preferred_Name: Tule River
UMLS_CUI: C1551687
Legacy_Concept_Name: Tule_River
has exact synonym: Tule River

Yuchi
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44244
Semantic_Type: Population Group
Preferred_Name: Yuchi
UMLS_CUI: C1551688
Legacy_Concept_Name: Yuchi
has exact synonym: Yuchi

Yuman
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44245
Semantic_Type: Population Group
Preferred_Name: Yuman
UMLS_CUI: C1551689
Legacy_Concept_Name: Yuman
has exact synonym: Yuman

Cocopah
type: Class
subclass of: Yuman
imported from: ncit.owl
code: C44246
Semantic_Type: Population Group
Preferred_Name: Cocopah
UMLS_CUI: C1551690
Legacy_Concept_Name: Cocopah
has exact synonym: Cocopah

Havasupai
type: Class
subclass of: Yuman
imported from: ncit.owl
code: C44247
Semantic_Type: Population Group
Preferred_Name: Havasupai
UMLS_CUI: C1551691
Legacy_Concept_Name: Havasupai
has exact synonym: Havasupai

Hualapai
type: Class
subclass of: Yuman
imported from: ncit.owl
code: C44248
Semantic_Type: Population Group
Preferred_Name: Hualapai
UMLS_CUI: C1551692
Legacy_Concept_Name: Hualapai
has exact synonym: Hualapai

Maricopa
type: Class
subclass of: Yuman
imported from: ncit.owl
code: C44249
Semantic_Type: Population Group
Preferred_Name: Maricopa
UMLS_CUI: C1551693
Legacy_Concept_Name: Maricopa
has exact synonym: Maricopa

Mohave
type: Class
subclass of: Yuman
imported from: ncit.owl
code: C44250
Semantic_Type: Population Group
Preferred_Name: Mohave
UMLS_CUI: C1551694
Legacy_Concept_Name: Mohave
has exact synonym: Mohave

Quechan
type: Class
subclass of: Yuman
imported from: ncit.owl
code: C44251
Semantic_Type: Population Group
Preferred_Name: Quechan
UMLS_CUI: C1551695
Legacy_Concept_Name: Quechan
has exact synonym: Quechan

Yurok
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C44252
Semantic_Type: Population Group
Preferred_Name: Yurok
UMLS_CUI: C1551697
Legacy_Concept_Name: Yurok
has exact synonym: Yurok

Coast Yurok
type: Class
subclass of: Yurok
imported from: ncit.owl
code: C44253
Semantic_Type: Population Group
Preferred_Name: Coast Yurok
UMLS_CUI: C1551698
Legacy_Concept_Name: Coast_Yurok
has exact synonym: Coast Yurok

Alaskan Athabascan
type: Class
subclass of: Alaska Indian
imported from: ncit.owl
code: C44254
Semantic_Type: Population Group
Preferred_Name: Alaskan Athabascan
UMLS_CUI: C1551699
Legacy_Concept_Name: Alaskan_Athabascan
has exact synonym: Alaskan Athabascan

Southeast Alaska
type: Class
subclass of: Alaska Indian
imported from: ncit.owl
code: C44257
Semantic_Type: Population Group
Preferred_Name: Southeast Alaska
UMLS_CUI: C1551770
Legacy_Concept_Name: Southeast_Alaska
has exact synonym: Southeast Alaska

Tlingit-Haida
type: Class
subclass of: Southeast Alaska
imported from: ncit.owl
code: C44259
Semantic_Type: Population Group
Preferred_Name: Tlingit-Haida
UMLS_CUI: C1551771
Legacy_Concept_Name: Tlingit_Haida
has exact synonym: Tlingit-Haida
has exact synonym: Tlinit-Haida

Tsimshian
type: Class
subclass of: Southeast Alaska
imported from: ncit.owl
code: C44261
Semantic_Type: Population Group
Preferred_Name: Tsimshian
UMLS_CUI: C1551792
Legacy_Concept_Name: Tsimshian
has exact synonym: Tsimshian

Metlakatla
type: Class
subclass of: Tsimshian
imported from: ncit.owl
code: C44263
Semantic_Type: Population Group
Preferred_Name: Metlakatla
UMLS_CUI: C1551793
Legacy_Concept_Name: Metlakatla
has exact synonym: Metlakatla

Greenland Eskimo
type: Class
subclass of: Eskimo
imported from: ncit.owl
code: C44265
Semantic_Type: Population Group
Preferred_Name: Greenland Eskimo
UMLS_CUI: C1551794
ALT_DEFINITION: The native people of Greenland.
Legacy_Concept_Name: Greenland_Eskimo
has exact synonym: GREENLAND INUIT
has exact synonym: Greenland Eskimo
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Inupiat Eskimo
type: Class
subclass of: Eskimo
imported from: ncit.owl
code: C44268
Semantic_Type: Population Group
Preferred_Name: Inupiat Eskimo
UMLS_CUI: C1551795
ALT_DEFINITION: The native people inhabiting the territory spanning the Norton Sound on the Bering Sea to the Canadian border.
Legacy_Concept_Name: Inupiat_Eskimo
has exact synonym: INUPIAT INUIT
has exact synonym: Inupiat Eskimo
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Siberian Eskimo
type: Class
subclass of: Eskimo
imported from: ncit.owl
code: C44269
Semantic_Type: Population Group
Preferred_Name: Siberian Eskimo
UMLS_CUI: C1551841
ALT_DEFINITION: The native Yupik people inhabiting the coast of the Chukchi Peninsula in the far northeast of the Russian Federation and on St. Lawrence Island in Alaska.
Legacy_Concept_Name: Siberian_Eskimo
has exact synonym: SIBERIAN ESKIMO
has exact synonym: Siberian Eskimo
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Yupik Eskimo
type: Class
subclass of: Eskimo
imported from: ncit.owl
code: C44270
Semantic_Type: Population Group
Preferred_Name: Yupik Eskimo
UMLS_CUI: C1551845
ALT_DEFINITION: The native people inhabiting western, southwestern, and southcentral Alaska and the Russian Far East.
Legacy_Concept_Name: Yupik_Eskimo
has exact synonym: YUPIK ESKIMO
has exact synonym: Yupik Eskimo
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Alutiiq Aleut
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44286
Semantic_Type: Population Group
Preferred_Name: Alutiiq Aleut
UMLS_CUI: C1553271
Legacy_Concept_Name: Alutiiq_Aleut
has exact synonym: Alutiiq Aleut

Tatitlek
type: Class
subclass of: Alutiiq Aleut
imported from: ncit.owl
code: C44287
Semantic_Type: Population Group
Preferred_Name: Tatitlek
UMLS_CUI: C1553272
Legacy_Concept_Name: Tatitlek
has exact synonym: Tatitlek

Ugashik
type: Class
subclass of: Alutiiq Aleut
imported from: ncit.owl
code: C44288
Semantic_Type: Population Group
Preferred_Name: Ugashik
UMLS_CUI: C1553273
Legacy_Concept_Name: Ugashik
has exact synonym: Ugashik

Bristol Bay Aleut
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44289
Semantic_Type: Population Group
Preferred_Name: Bristol Bay Aleut
UMLS_CUI: C1553507
Legacy_Concept_Name: Bristol_Bay_Aleut
has exact synonym: Bristol Bay Aleut

Chugach Aleut
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44290
Semantic_Type: Population Group
Preferred_Name: Chugach Aleut
UMLS_CUI: C1553284
Legacy_Concept_Name: Chugach_Aleut
has exact synonym: Chugach Aleut

Eyak
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44486
Semantic_Type: Population Group
Preferred_Name: Eyak
UMLS_CUI: C1553289
Legacy_Concept_Name: Eyak
has exact synonym: Eyak

Koniag Aleut
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44487
Semantic_Type: Population Group
Preferred_Name: Koniag Aleut
UMLS_CUI: C1553290
Legacy_Concept_Name: Koniag_Aleut
has exact synonym: Koniag Aleut

Sugpiaq
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44488
Semantic_Type: Population Group
Preferred_Name: Sugpiaq
UMLS_CUI: C1553299
Legacy_Concept_Name: Sugpiaq
has exact synonym: Sugpiaq

Suqpigaq
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44489
Semantic_Type: Population Group
Preferred_Name: Suqpigaq
UMLS_CUI: C1553300
Legacy_Concept_Name: Suqpigaq
has exact synonym: Suqpigaq

Unangan Aleut
type: Class
subclass of: Aleut
imported from: ncit.owl
code: C44490
Semantic_Type: Population Group
Preferred_Name: Unangan Aleut
UMLS_CUI: C1553301
Legacy_Concept_Name: Unangan_Aleut
has exact synonym: Unangan Aleut

Chenega
type: Class
subclass of: Chugach Aleut
imported from: ncit.owl
code: C44491
Semantic_Type: Population Group
Preferred_Name: Chenega
UMLS_CUI: C1553285
Legacy_Concept_Name: Chenega
has exact synonym: Chenega

Chugach Corporation
type: Class
subclass of: Chugach Aleut
imported from: ncit.owl
code: C44492
Semantic_Type: Population Group
Preferred_Name: Chugach Corporation
UMLS_CUI: C1553286
Legacy_Concept_Name: Chugach_Corporation
has exact synonym: Chugach Corporation

English Bay
type: Class
subclass of: Chugach Aleut
imported from: ncit.owl
code: C44493
Semantic_Type: Population Group
Preferred_Name: English Bay
UMLS_CUI: C1553287
Legacy_Concept_Name: English_Bay
has exact synonym: English Bay

Port Graham
type: Class
subclass of: Chugach Aleut
imported from: ncit.owl
code: C44494
Semantic_Type: Population Group
Preferred_Name: Port Graham
UMLS_CUI: C1553288
Legacy_Concept_Name: Port_Graham
has exact synonym: Port Graham

Akhiok
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44495
Semantic_Type: Population Group
Preferred_Name: Akhiok
UMLS_CUI: C1553291
Legacy_Concept_Name: Akhiok
has exact synonym: Akhiok

Agdaagux
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44496
Semantic_Type: Population Group
Preferred_Name: Agdaagux
UMLS_CUI: C1553292
Legacy_Concept_Name: Agdaagux
has exact synonym: Agdaagux

Karluk
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44497
Semantic_Type: Population Group
Preferred_Name: Karluk
UMLS_CUI: C1553293
Legacy_Concept_Name: Karluk
has exact synonym: Karluk

Kodiak
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44498
Semantic_Type: Population Group
Preferred_Name: Kodiak
UMLS_CUI: C1553294
Legacy_Concept_Name: Kodiak
has exact synonym: Kodiak

Larsen Bay
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44499
Semantic_Type: Population Group
Preferred_Name: Larsen Bay
UMLS_CUI: C1553295
Legacy_Concept_Name: Larsen_Bay
has exact synonym: Larsen Bay

Old Harbor
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44500
Semantic_Type: Population Group
Preferred_Name: Old Harbor
UMLS_CUI: C1553296
Legacy_Concept_Name: Old_Harbor
has exact synonym: Old Harbor

Ouzinkie
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44501
Semantic_Type: Population Group
Preferred_Name: Ouzinkie
UMLS_CUI: C1553297
Legacy_Concept_Name: Ouzinkie
has exact synonym: Ouzinkie

Port Lions
type: Class
subclass of: Koniag Aleut
imported from: ncit.owl
code: C44502
Semantic_Type: Population Group
Preferred_Name: Port Lions
UMLS_CUI: C1553298
Legacy_Concept_Name: Port_Lions
has exact synonym: Port Lions

Gambell
type: Class
subclass of: Siberian Eskimo
imported from: ncit.owl
code: C44503
Semantic_Type: Population Group
Preferred_Name: Gambell
UMLS_CUI: C1551842
Legacy_Concept_Name: Gambell
has exact synonym: Gambell

Savoonga
type: Class
subclass of: Siberian Eskimo
imported from: ncit.owl
code: C44504
Semantic_Type: Population Group
Preferred_Name: Savoonga
UMLS_CUI: C1551843
Legacy_Concept_Name: Savoonga
has exact synonym: Savoonga

Siberian Yupik
type: Class
subclass of: Siberian Eskimo
imported from: ncit.owl
code: C44505
Semantic_Type: Population Group
Preferred_Name: Siberian Yupik
UMLS_CUI: C1551844
Legacy_Concept_Name: Siberian_Yupik
has exact synonym: Siberian Yupik

Cahto
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44506
Semantic_Type: Population Group
Preferred_Name: Cahto
UMLS_CUI: C1555070
Legacy_Concept_Name: Cahto
has exact synonym: Cahto

Chimariko
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44507
Semantic_Type: Population Group
Preferred_Name: Chimariko
UMLS_CUI: C1555071
Legacy_Concept_Name: Chimariko
has exact synonym: Chimariko

Coast Miwok
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44508
Semantic_Type: Population Group
Preferred_Name: Coast Miwok
UMLS_CUI: C1555072
Legacy_Concept_Name: Coast_Miwok
has exact synonym: Coast Miwok

Digger
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44509
Semantic_Type: Population Group
Preferred_Name: Digger
UMLS_CUI: C1555073
Legacy_Concept_Name: Digger
has exact synonym: Digger

Kawaiisu
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44510
Semantic_Type: Population Group
Preferred_Name: Kawaiisu
UMLS_CUI: C1555074
Legacy_Concept_Name: Kawaiisu
has exact synonym: Kawaiisu

Kern River
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44511
Semantic_Type: Population Group
Preferred_Name: Kern River
UMLS_CUI: C1555075
Legacy_Concept_Name: Kern_River
has exact synonym: Kern River

Mattole
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44512
Semantic_Type: Population Group
Preferred_Name: Mattole
UMLS_CUI: C1555076
Legacy_Concept_Name: Mattole
has exact synonym: Mattole

Red Wood
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44513
Semantic_Type: Population Group
Preferred_Name: Red Wood
UMLS_CUI: C1555077
Legacy_Concept_Name: Red_Wood
has exact synonym: Red Wood

Santa Rosa
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44514
Semantic_Type: Population Group
Preferred_Name: Santa Rosa
UMLS_CUI: C1555078
Legacy_Concept_Name: Santa_Rosa
has exact synonym: Santa Rosa

Takelma
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44515
Semantic_Type: Population Group
Preferred_Name: Takelma
UMLS_CUI: C1555079
Legacy_Concept_Name: Takelma
has exact synonym: Takelma

Wappo
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44516
Semantic_Type: Population Group
Preferred_Name: Wappo
UMLS_CUI: C1555080
Legacy_Concept_Name: Wappo
has exact synonym: Wappo

Yana
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44517
Semantic_Type: Population Group
Preferred_Name: Yana
UMLS_CUI: C1555081
Legacy_Concept_Name: Yana
has exact synonym: Yana

Yuki
type: Class
subclass of: California Tribes
imported from: ncit.owl
code: C44518
Semantic_Type: Population Group
Preferred_Name: Yuki
UMLS_CUI: C1555082
Legacy_Concept_Name: Yuki
has exact synonym: Yuki

Campo
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44525
Semantic_Type: Population Group
Preferred_Name: Campo
UMLS_CUI: C1555189
Legacy_Concept_Name: Campo
has exact synonym: Campo

Capitan Grande
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44526
Semantic_Type: Population Group
Preferred_Name: Capitan Grande
UMLS_CUI: C1555190
Legacy_Concept_Name: Capitan_Grande
has exact synonym: Capitan Grande

Cuyapaipe
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44527
Semantic_Type: Population Group
Preferred_Name: Cuyapaipe
UMLS_CUI: C1555191
Legacy_Concept_Name: Cuyapaipe
has exact synonym: Cuyapaipe

La Posta
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44528
Semantic_Type: Population Group
Preferred_Name: La Posta
UMLS_CUI: C1555192
Legacy_Concept_Name: La_Posta
has exact synonym: La Posta

Manzanita
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44529
Semantic_Type: Population Group
Preferred_Name: Manzanita
UMLS_CUI: C1555193
Legacy_Concept_Name: Manzanita
has exact synonym: Manzanita

Mesa Grande
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44530
Semantic_Type: Population Group
Preferred_Name: Mesa Grande
UMLS_CUI: C1555194
Legacy_Concept_Name: Mesa_Grande
has exact synonym: Mesa Grande

San Pasqual
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44531
Semantic_Type: Population Group
Preferred_Name: San Pasqual
UMLS_CUI: C1555195
Legacy_Concept_Name: San_Pasqual
has exact synonym: San Pasqual

Santa Ysabel
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44532
Semantic_Type: Population Group
Preferred_Name: Santa Ysabel
UMLS_CUI: C1555196
Legacy_Concept_Name: Santa_Ysabel
has exact synonym: Santa Ysabel

Sycuan
type: Class
subclass of: Diegueno
imported from: ncit.owl
code: C44533
Semantic_Type: Population Group
Preferred_Name: Sycuan
UMLS_CUI: C1555197
Legacy_Concept_Name: Sycuan
has exact synonym: Sycuan

Bishop
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44534
Semantic_Type: Population Group
Preferred_Name: Bishop
UMLS_CUI: C1551458
Legacy_Concept_Name: Bishop
has exact synonym: Bishop

Bridgeport
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44535
Semantic_Type: Population Group
Preferred_Name: Bridgeport
UMLS_CUI: C1551459
Legacy_Concept_Name: Bridgeport
has exact synonym: Bridgeport

Burns Paiute
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44536
Semantic_Type: Population Group
Preferred_Name: Burns Paiute
UMLS_CUI: C1551460
Legacy_Concept_Name: Burns_Paiute
has exact synonym: Burns Paiute

Cedarville
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44537
Semantic_Type: Population Group
Preferred_Name: Cedarville
UMLS_CUI: C1551461
Legacy_Concept_Name: Cedarville
has exact synonym: Cedarville

Fort Bidwell
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44538
Semantic_Type: Population Group
Preferred_Name: Fort Bidwell
UMLS_CUI: C1551462
Legacy_Concept_Name: Fort_Bidwell
has exact synonym: Fort Bidwell

Fort Independence
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44539
Semantic_Type: Population Group
Preferred_Name: Fort Independence
UMLS_CUI: C1551463
Legacy_Concept_Name: Fort_Independence
has exact synonym: Fort Independence

Kaibab
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44540
Semantic_Type: Population Group
Preferred_Name: Kaibab
UMLS_CUI: C1551464
Legacy_Concept_Name: Kaibab
has exact synonym: Kaibab

Las Vegas
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44541
Semantic_Type: Population Group
Preferred_Name: Las Vegas
UMLS_CUI: C1551465
Legacy_Concept_Name: Las_Vegas
has exact synonym: Las Vegas

Lone Pine
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44542
Semantic_Type: Population Group
Preferred_Name: Lone Pine
UMLS_CUI: C1551466
Legacy_Concept_Name: Lone_Pine
has exact synonym: Lone Pine

Lovelock
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44543
Semantic_Type: Population Group
Preferred_Name: Lovelock
UMLS_CUI: C1551467
Legacy_Concept_Name: Lovelock
has exact synonym: Lovelock

Malheur Paiute
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44544
Semantic_Type: Population Group
Preferred_Name: Malheur Paiute
UMLS_CUI: C1551468
Legacy_Concept_Name: Malheur_Paiute
has exact synonym: Malheur Paiute

Moapa
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44545
Semantic_Type: Population Group
Preferred_Name: Moapa
UMLS_CUI: C1551469
Legacy_Concept_Name: Moapa
has exact synonym: Moapa

Northern Paiute
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44546
Semantic_Type: Population Group
Preferred_Name: Northern Paiute
UMLS_CUI: C1551470
Legacy_Concept_Name: Northern_Paiute
has exact synonym: Northern Paiute

Owens Valley
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44547
Semantic_Type: Population Group
Preferred_Name: Owens Valley
UMLS_CUI: C1551471
Legacy_Concept_Name: Owens_Valley
has exact synonym: Owens Valley

Pyramid Lake
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44548
Semantic_Type: Population Group
Preferred_Name: Pyramid Lake
UMLS_CUI: C1551472
Legacy_Concept_Name: Pyramid_Lake
has exact synonym: Pyramid Lake

San Juan Southern Paiute
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44549
Semantic_Type: Population Group
Preferred_Name: San Juan Southern Paiute
UMLS_CUI: C1551473
Legacy_Concept_Name: San_Juan_Southern_Paiute
has exact synonym: San Juan Southern Paiute

Southern Paiute
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44550
Semantic_Type: Population Group
Preferred_Name: Southern Paiute
UMLS_CUI: C1551474
Legacy_Concept_Name: Southern_Paiute
has exact synonym: Southern Paiute

Summit Lake
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44551
Semantic_Type: Population Group
Preferred_Name: Summit Lake
UMLS_CUI: C1551475
Legacy_Concept_Name: Summit_Lake
has exact synonym: Summit Lake

Utu Utu Gwaitu Paiute
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44552
Semantic_Type: Population Group
Preferred_Name: Utu Utu Gwaitu Paiute
UMLS_CUI: C1551476
Legacy_Concept_Name: Utu_Utu_Gwaitu_Paiute
has exact synonym: Utu Utu Gwaitu Paiute

Walker River
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44553
Semantic_Type: Population Group
Preferred_Name: Walker River
UMLS_CUI: C1551477
Legacy_Concept_Name: Walker_River
has exact synonym: Walker River

Yerington Paiute
type: Class
subclass of: Paiute
imported from: ncit.owl
code: C44554
Semantic_Type: Population Group
Preferred_Name: Yerington Paiute
UMLS_CUI: C1551478
Legacy_Concept_Name: Yerington_Paiute
has exact synonym: Yerington Paiute

Battle Mountain
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44555
Semantic_Type: Population Group
Preferred_Name: Battle Mountain
UMLS_CUI: C1551588
Legacy_Concept_Name: Battle_Mountain
has exact synonym: Battle Mountain

Duckwater
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44556
Semantic_Type: Population Group
Preferred_Name: Duckwater
UMLS_CUI: C1551589
Legacy_Concept_Name: Duckwater
has exact synonym: Duckwater

Elko
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44557
Semantic_Type: Population Group
Preferred_Name: Elko
UMLS_CUI: C1551590
Legacy_Concept_Name: Elko
has exact synonym: Elko

Ely
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44558
Semantic_Type: Population Group
Preferred_Name: Ely
UMLS_CUI: C1551591
Legacy_Concept_Name: Ely
has exact synonym: Ely

Goshute
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44559
Semantic_Type: Population Group
Preferred_Name: Goshute
UMLS_CUI: C1551592
Legacy_Concept_Name: Goshute
has exact synonym: Goshute

Panamint
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44560
Semantic_Type: Population Group
Preferred_Name: Panamint
UMLS_CUI: C1551593
Legacy_Concept_Name: Panamint
has exact synonym: Panamint

Ruby Valley
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44561
Semantic_Type: Population Group
Preferred_Name: Ruby Valley
UMLS_CUI: C1551594
Legacy_Concept_Name: Ruby_Valley
has exact synonym: Ruby Valley

Skull Valley
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44562
Semantic_Type: Population Group
Preferred_Name: Skull Valley
UMLS_CUI: C1551595
Legacy_Concept_Name: Skull_Valley
has exact synonym: Skull Valley

South Fork Shoshone
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44563
Semantic_Type: Population Group
Preferred_Name: South Fork Shoshone
UMLS_CUI: C1551596
Legacy_Concept_Name: South_Fork_Shoshone
has exact synonym: South Fork Shoshone

Te Moak Western Shoshone
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44564
Semantic_Type: Population Group
Preferred_Name: Te Moak Western Shoshone
UMLS_CUI: C1551597
Legacy_Concept_Name: Te_Moak_Western_Shoshone
has exact synonym: Te Moak Western Shoshone
has exact synonym: Te-Moak Western Shoshone

Timbi Sha Shoshone
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44565
Semantic_Type: Population Group
Preferred_Name: Timbi Sha Shoshone
UMLS_CUI: C1551598
Legacy_Concept_Name: Timbi_Sha_Shoshone
has exact synonym: Timbi Sha Shoshone
has exact synonym: Timbi-Sha Shoshone

Washakie
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44566
Semantic_Type: Population Group
Preferred_Name: Washakie
UMLS_CUI: C1551599
Legacy_Concept_Name: Washakie
has exact synonym: Washakie

Wind River Shoshone
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44567
Semantic_Type: Population Group
Preferred_Name: Wind River Shoshone
UMLS_CUI: C1551600
Legacy_Concept_Name: Wind_River_Shoshone
has exact synonym: Wind River Shoshone

Yomba
type: Class
subclass of: Shoshone
imported from: ncit.owl
code: C44568
Semantic_Type: Population Group
Preferred_Name: Yomba
UMLS_CUI: C1551601
Legacy_Concept_Name: Yomba
has exact synonym: Yomba

Akiachak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44569
Semantic_Type: Population Group
Preferred_Name: Akiachak
UMLS_CUI: C1551846
Legacy_Concept_Name: Akiachak
has exact synonym: Akiachak

Akiak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44570
Semantic_Type: Population Group
Preferred_Name: Akiak
UMLS_CUI: C1551847
Legacy_Concept_Name: Akiak
has exact synonym: Akiak

Alakanuk
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44571
Semantic_Type: Population Group
Preferred_Name: Alakanuk
UMLS_CUI: C1551848
Legacy_Concept_Name: Alakanuk
has exact synonym: Alakanuk

Aleknagik
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44572
Semantic_Type: Population Group
Preferred_Name: Aleknagik
UMLS_CUI: C1551849
Legacy_Concept_Name: Aleknagik
has exact synonym: Aleknagik

Andreafsky
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44573
Semantic_Type: Population Group
Preferred_Name: Andreafsky
UMLS_CUI: C1551850
Legacy_Concept_Name: Andreafsky
has exact synonym: Andreafsky

Aniak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44574
Semantic_Type: Population Group
Preferred_Name: Aniak
UMLS_CUI: C1551851
Legacy_Concept_Name: Aniak
has exact synonym: Aniak

Atmautluak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44575
Semantic_Type: Population Group
Preferred_Name: Atmautluak
UMLS_CUI: C1551852
Legacy_Concept_Name: Atmautluak
has exact synonym: Atmautluak

Bethel
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44576
Semantic_Type: Population Group
Preferred_Name: Bethel
UMLS_CUI: C1551853
Legacy_Concept_Name: Bethel
has exact synonym: Bethel

Bill Moore's Slough
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44577
Semantic_Type: Population Group
Preferred_Name: Bill Moore's Slough
UMLS_CUI: C1551854
Legacy_Concept_Name: Bill_Moore_s_Slough
has exact synonym: Bill Moore's Slough

Bristol Bay Yupik
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44578
Semantic_Type: Population Group
Preferred_Name: Bristol Bay Yupik
UMLS_CUI: C1551855
Legacy_Concept_Name: Bristol_Bay_Yupik
has exact synonym: Bristol Bay Yupik

Calista Yupik
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44579
Semantic_Type: Population Group
Preferred_Name: Calista Yupik
UMLS_CUI: C1551856
Legacy_Concept_Name: Calista_Yupik
has exact synonym: Calista Yupik

Chefornak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44580
Semantic_Type: Population Group
Preferred_Name: Chefornak
UMLS_CUI: C1551857
Legacy_Concept_Name: Chefornak
has exact synonym: Chefornak

Chevak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44581
Semantic_Type: Population Group
Preferred_Name: Chevak
UMLS_CUI: C1551858
Legacy_Concept_Name: Chevak
has exact synonym: Chevak

Chuathbaluk
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44582
Semantic_Type: Population Group
Preferred_Name: Chuathbaluk
UMLS_CUI: C1551859
Legacy_Concept_Name: Chuathbaluk
has exact synonym: Chuathbaluk

Clark's Point
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44583
Semantic_Type: Population Group
Preferred_Name: Clark's Point
UMLS_CUI: C1551860
Legacy_Concept_Name: Clark_s_Point
has exact synonym: Clark's Point

Crooked Creek
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44584
Semantic_Type: Population Group
Preferred_Name: Crooked Creek
UMLS_CUI: C1551861
Legacy_Concept_Name: Crooked_Creek
has exact synonym: Crooked Creek

Dillingham
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44585
Semantic_Type: Population Group
Preferred_Name: Dillingham
UMLS_CUI: C1551862
Legacy_Concept_Name: Dillingham
has exact synonym: Dillingham

Eek
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44586
Semantic_Type: Population Group
Preferred_Name: Eek
UMLS_CUI: C1551863
Legacy_Concept_Name: Eek
has exact synonym: Eek

Ekuk
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44587
Semantic_Type: Population Group
Preferred_Name: Ekuk
UMLS_CUI: C1551864
Legacy_Concept_Name: Ekuk
has exact synonym: Ekuk

Ekwok
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44588
Semantic_Type: Population Group
Preferred_Name: Ekwok
UMLS_CUI: C1551865
Legacy_Concept_Name: Ekwok
has exact synonym: Ekwok

Emmonak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44589
Semantic_Type: Population Group
Preferred_Name: Emmonak
UMLS_CUI: C1551866
Legacy_Concept_Name: Emmonak
has exact synonym: Emmonak

Goodnews Bay
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44590
Semantic_Type: Population Group
Preferred_Name: Goodnews Bay
UMLS_CUI: C1551867
Legacy_Concept_Name: Goodnews_Bay
has exact synonym: Goodnews Bay

Hooper Bay
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44591
Semantic_Type: Population Group
Preferred_Name: Hooper Bay
UMLS_CUI: C1551868
Legacy_Concept_Name: Hooper_Bay
has exact synonym: Hooper Bay

Iqurmuit Russian Mission
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44592
Semantic_Type: Population Group
Preferred_Name: Iqurmuit Russian Mission
UMLS_CUI: C1551869
Legacy_Concept_Name: Iqurmuit_Russian_Mission
has exact synonym: Iqurmuit (Russian Mission)
has exact synonym: Iqurmuit Russian Mission

Kalskag
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44593
Semantic_Type: Population Group
Preferred_Name: Kalskag
UMLS_CUI: C1551870
Legacy_Concept_Name: Kalskag
has exact synonym: Kalskag

Kasigluk
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44594
Semantic_Type: Population Group
Preferred_Name: Kasigluk
UMLS_CUI: C1551871
Legacy_Concept_Name: Kasigluk
has exact synonym: Kasigluk

Kipnuk
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44595
Semantic_Type: Population Group
Preferred_Name: Kipnuk
UMLS_CUI: C1551872
Legacy_Concept_Name: Kipnuk
has exact synonym: Kipnuk

Koliganek
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44596
Semantic_Type: Population Group
Preferred_Name: Koliganek
UMLS_CUI: C1551873
Legacy_Concept_Name: Koliganek
has exact synonym: Koliganek

Kongiganak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44597
Semantic_Type: Population Group
Preferred_Name: Kongiganak
UMLS_CUI: C1551874
Legacy_Concept_Name: Kongiganak
has exact synonym: Kongiganak

Kotlik
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44598
Semantic_Type: Population Group
Preferred_Name: Kotlik
UMLS_CUI: C1551875
Legacy_Concept_Name: Kotlik
has exact synonym: Kotlik

Kwethluk
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44599
Semantic_Type: Population Group
Preferred_Name: Kwethluk
UMLS_CUI: C1551876
Legacy_Concept_Name: Kwethluk
has exact synonym: Kwethluk

Kwigillingok
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44600
Semantic_Type: Population Group
Preferred_Name: Kwigillingok
UMLS_CUI: C1551877
Legacy_Concept_Name: Kwigillingok
has exact synonym: Kwigillingok

Levelock
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44601
Semantic_Type: Population Group
Preferred_Name: Levelock
UMLS_CUI: C1551878
Legacy_Concept_Name: Levelock
has exact synonym: Levelock

Lower Kalskag
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44602
Semantic_Type: Population Group
Preferred_Name: Lower Kalskag
UMLS_CUI: C1551879
Legacy_Concept_Name: Lower_Kalskag
has exact synonym: Lower Kalskag

Manokotak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44603
Semantic_Type: Population Group
Preferred_Name: Manokotak
UMLS_CUI: C1551880
Legacy_Concept_Name: Manokotak
has exact synonym: Manokotak

Marshall
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44604
Semantic_Type: Population Group
Preferred_Name: Marshall
UMLS_CUI: C1551881
Legacy_Concept_Name: Marshall
has exact synonym: Marshall

Mekoryuk
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44605
Semantic_Type: Population Group
Preferred_Name: Mekoryuk
UMLS_CUI: C1551882
Legacy_Concept_Name: Mekoryuk
has exact synonym: Mekoryuk

Mountain Village
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44606
Semantic_Type: Population Group
Preferred_Name: Mountain Village
UMLS_CUI: C1551883
Legacy_Concept_Name: Mountain_Village
has exact synonym: Mountain Village

Naknek
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44607
Semantic_Type: Population Group
Preferred_Name: Naknek
UMLS_CUI: C1551884
Legacy_Concept_Name: Naknek
has exact synonym: Naknek

Napaumute
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44608
Semantic_Type: Population Group
Preferred_Name: Napaumute
UMLS_CUI: C1551885
Legacy_Concept_Name: Napaumute
has exact synonym: Napaumute

Napakiak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44609
Semantic_Type: Population Group
Preferred_Name: Napakiak
UMLS_CUI: C1551886
Legacy_Concept_Name: Napakiak
has exact synonym: Napakiak

Napaskiak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44610
Semantic_Type: Population Group
Preferred_Name: Napaskiak
UMLS_CUI: C1551887
Legacy_Concept_Name: Napaskiak
has exact synonym: Napaskiak

Newhalen
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44611
Semantic_Type: Population Group
Preferred_Name: Newhalen
UMLS_CUI: C1553245
Legacy_Concept_Name: Newhalen
has exact synonym: Newhalen

New Stuyahok
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44612
Semantic_Type: Population Group
Preferred_Name: New Stuyahok
UMLS_CUI: C1553246
Legacy_Concept_Name: New_Stuyahok
has exact synonym: New Stuyahok

Newtok
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44613
Semantic_Type: Population Group
Preferred_Name: Newtok
UMLS_CUI: C1553247
Legacy_Concept_Name: Newtok
has exact synonym: Newtok

Nightmute
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44614
Semantic_Type: Population Group
Preferred_Name: Nightmute
UMLS_CUI: C1553248
Legacy_Concept_Name: Nightmute
has exact synonym: Nightmute

Nunapitchukv
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44615
Semantic_Type: Population Group
Preferred_Name: Nunapitchukv
UMLS_CUI: C1553249
Legacy_Concept_Name: Nunapitchukv
has exact synonym: Nunapitchukv

Oscarville
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44616
Semantic_Type: Population Group
Preferred_Name: Oscarville
UMLS_CUI: C1553250
Legacy_Concept_Name: Oscarville
has exact synonym: Oscarville

Pilot Station
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44617
Semantic_Type: Population Group
Preferred_Name: Pilot Station
UMLS_CUI: C1553251
Legacy_Concept_Name: Pilot_Station
has exact synonym: Pilot Station

Pitkas Point
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44618
Semantic_Type: Population Group
Preferred_Name: Pitkas Point
UMLS_CUI: C1553252
Legacy_Concept_Name: Pitkas_Point
has exact synonym: Pitkas Point

Portage Creek
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44619
Semantic_Type: Population Group
Preferred_Name: Portage Creek
UMLS_CUI: C1553254
Legacy_Concept_Name: Portage_Creek
has exact synonym: Portage Creek

Quinhagak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44620
Semantic_Type: Population Group
Preferred_Name: Quinhagak
UMLS_CUI: C1553255
Legacy_Concept_Name: Quinhagak
has exact synonym: Quinhagak

Red Devil
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44621
Semantic_Type: Population Group
Preferred_Name: Red Devil
UMLS_CUI: C1553256
Legacy_Concept_Name: Red_Devil
has exact synonym: Red Devil

Scammon Bay
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44623
Semantic_Type: Population Group
Preferred_Name: Scammon Bay
UMLS_CUI: C1553258
Legacy_Concept_Name: Scammon_Bay
has exact synonym: Scammon Bay

Sheldon's Point
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44624
Semantic_Type: Population Group
Preferred_Name: Sheldon's Point
UMLS_CUI: C1553259
Legacy_Concept_Name: Sheldon_s_Point
has exact synonym: Sheldon's Point

Sleetmute
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44625
Semantic_Type: Population Group
Preferred_Name: Sleetmute
UMLS_CUI: C1553260
Legacy_Concept_Name: Sleetmute
has exact synonym: Sleetmute

Stebbins
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44626
Semantic_Type: Population Group
Preferred_Name: Stebbins
UMLS_CUI: C1553261
Legacy_Concept_Name: Stebbins
has exact synonym: Stebbins

Togiak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44627
Semantic_Type: Population Group
Preferred_Name: Togiak
UMLS_CUI: C1553262
Legacy_Concept_Name: Togiak
has exact synonym: Togiak

Toksook
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44628
Semantic_Type: Population Group
Preferred_Name: Toksook
UMLS_CUI: C1553263
Legacy_Concept_Name: Toksook
has exact synonym: Toksook

Tulukskak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44629
Semantic_Type: Population Group
Preferred_Name: Tulukskak
UMLS_CUI: C1553264
Legacy_Concept_Name: Tulukskak
has exact synonym: Tulukskak

Tuntutuliak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44630
Semantic_Type: Population Group
Preferred_Name: Tuntutuliak
UMLS_CUI: C1553265
Legacy_Concept_Name: Tuntutuliak
has exact synonym: Tuntutuliak

Tununak
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44631
Semantic_Type: Population Group
Preferred_Name: Tununak
UMLS_CUI: C1553266
Legacy_Concept_Name: Tununak
has exact synonym: Tununak

Twin Hills
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44632
Semantic_Type: Population Group
Preferred_Name: Twin Hills
UMLS_CUI: C1553267
Legacy_Concept_Name: Twin_Hills
has exact synonym: Twin Hills

Georgetown
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44633
Semantic_Type: Population Group
Preferred_Name: Georgetown
UMLS_CUI: C1553268
Legacy_Concept_Name: Georgetown
has exact synonym: Georgetown

Umkumiate
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C44635
Semantic_Type: Population Group
Preferred_Name: Umkumiate
UMLS_CUI: C1553270
Legacy_Concept_Name: Umkumiate
has exact synonym: Umkumiate

Akutan
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44636
Semantic_Type: Population Group
Preferred_Name: Akutan
UMLS_CUI: C1553302
Legacy_Concept_Name: Akutan
has exact synonym: Akutan

Aleut Corporation
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44637
Semantic_Type: Population Group
Preferred_Name: Aleut Corporation
UMLS_CUI: C1553303
Legacy_Concept_Name: Aleut_Corporation
has exact synonym: Aleut Corporation

Aleutian Islander
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44638
Semantic_Type: Population Group
Preferred_Name: Aleutian Islander
UMLS_CUI: C1553305
Legacy_Concept_Name: Aleutian_Islander
has exact synonym: Aleutian Islander

Atka
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44639
Semantic_Type: Population Group
Preferred_Name: Atka
UMLS_CUI: C1553306
Legacy_Concept_Name: Atka
has exact synonym: Atka

Belkofski
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44640
Semantic_Type: Population Group
Preferred_Name: Belkofski
UMLS_CUI: C1553307
Legacy_Concept_Name: Belkofski
has exact synonym: Belkofski

Chignik Lagoon
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44641
Semantic_Type: Population Group
Preferred_Name: Chignik Lagoon
UMLS_CUI: C1553308
Legacy_Concept_Name: Chignik_Lagoon
has exact synonym: Chignik Lagoon

King Cove
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44642
Semantic_Type: Population Group
Preferred_Name: King Cove
UMLS_CUI: C1553309
Legacy_Concept_Name: King_Cove
has exact synonym: King Cove

False Pass
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44643
Semantic_Type: Population Group
Preferred_Name: False Pass
UMLS_CUI: C1553310
Legacy_Concept_Name: False_Pass
has exact synonym: False Pass

Nelson Lagoon
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44644
Semantic_Type: Population Group
Preferred_Name: Nelson Lagoon
UMLS_CUI: C1553311
Legacy_Concept_Name: Nelson_Lagoon
has exact synonym: Nelson Lagoon

Nikolski
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44645
Semantic_Type: Population Group
Preferred_Name: Nikolski
UMLS_CUI: C1553312
Legacy_Concept_Name: Nikolski
has exact synonym: Nikolski

Pauloff Harbor
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44646
Semantic_Type: Population Group
Preferred_Name: Pauloff Harbor
UMLS_CUI: C1553313
Legacy_Concept_Name: Pauloff_Harbor
has exact synonym: Pauloff Harbor

Qagan Toyagungin
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44647
Semantic_Type: Population Group
Preferred_Name: Qagan Toyagungin
UMLS_CUI: C1553314
Legacy_Concept_Name: Qagan_Toyagungin
has exact synonym: Qagan Toyagungin

Qawalangin
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44648
Semantic_Type: Population Group
Preferred_Name: Qawalangin
UMLS_CUI: C1553315
Legacy_Concept_Name: Qawalangin
has exact synonym: Qawalangin

Sand Point
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44651
Semantic_Type: Population Group
Preferred_Name: Sand Point
UMLS_CUI: C1553318
Legacy_Concept_Name: Sand_Point
has exact synonym: Sand Point

South Naknek
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44652
Semantic_Type: Population Group
Preferred_Name: South Naknek
UMLS_CUI: C1553319
Legacy_Concept_Name: South_Naknek
has exact synonym: South Naknek

Unalaska
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44653
Semantic_Type: Population Group
Preferred_Name: Unalaska
UMLS_CUI: C1553320
Legacy_Concept_Name: Unalaska
has exact synonym: Unalaska

Unga
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C44654
Semantic_Type: Population Group
Preferred_Name: Unga
UMLS_CUI: C1553321
Legacy_Concept_Name: Unga
has exact synonym: Unga

Chignik
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44655
Semantic_Type: Population Group
Preferred_Name: Chignik
UMLS_CUI: C1553274
Legacy_Concept_Name: Chignik
has exact synonym: Chignik

Chignik Lake
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44656
Semantic_Type: Population Group
Preferred_Name: Chignik Lake
UMLS_CUI: C1553275
Legacy_Concept_Name: Chignik_Lake
has exact synonym: Chignik Lake

Egegik
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44657
Semantic_Type: Population Group
Preferred_Name: Egegik
UMLS_CUI: C1553276
Legacy_Concept_Name: Egegik
has exact synonym: Egegik

Igiugig
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44658
Semantic_Type: Population Group
Preferred_Name: Igiugig
UMLS_CUI: C1553277
Legacy_Concept_Name: Igiugig
has exact synonym: Igiugig

Ivanof Bay
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44659
Semantic_Type: Population Group
Preferred_Name: Ivanof Bay
UMLS_CUI: C1553278
Legacy_Concept_Name: Ivanof_Bay
has exact synonym: Ivanof Bay

King Salmon
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44660
Semantic_Type: Population Group
Preferred_Name: King Salmon
UMLS_CUI: C1553279
Legacy_Concept_Name: King_Salmon
has exact synonym: King Salmon

Kokhanok
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44661
Semantic_Type: Population Group
Preferred_Name: Kokhanok
UMLS_CUI: C1553280
Legacy_Concept_Name: Kokhanok
has exact synonym: Kokhanok

Perryville
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44662
Semantic_Type: Population Group
Preferred_Name: Perryville
UMLS_CUI: C1553281
Legacy_Concept_Name: Perryville
has exact synonym: Perryville

Pilot Point
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44663
Semantic_Type: Population Group
Preferred_Name: Pilot Point
UMLS_CUI: C1553282
Legacy_Concept_Name: Pilot_Point
has exact synonym: Pilot Point

Port Heiden
type: Class
subclass of: Bristol Bay Aleut
imported from: ncit.owl
code: C44664
Semantic_Type: Population Group
Preferred_Name: Port Heiden
UMLS_CUI: C1553283
Legacy_Concept_Name: Port_Heiden
has exact synonym: Port Heiden

Ambler
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44665
Semantic_Type: Population Group
Preferred_Name: Ambler
UMLS_CUI: C1551796
Legacy_Concept_Name: Ambler
has exact synonym: Ambler

Anaktuvuk
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44666
Semantic_Type: Population Group
Preferred_Name: Anaktuvuk
UMLS_CUI: C1551797
Legacy_Concept_Name: Anaktuvuk
has exact synonym: Anaktuvuk

Anaktuvuk Pass
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44667
Semantic_Type: Population Group
Preferred_Name: Anaktuvuk Pass
UMLS_CUI: C1551798
Legacy_Concept_Name: Anaktuvuk_Pass
has exact synonym: Anaktuvuk Pass

Arctic Slope Inupiat
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44668
Semantic_Type: Population Group
Preferred_Name: Arctic Slope Inupiat
UMLS_CUI: C1551799
Legacy_Concept_Name: Arctic_Slope_Inupiat
has exact synonym: Arctic Slope Inupiat

Arctic Slope Corporation
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44669
Semantic_Type: Population Group
Preferred_Name: Arctic Slope Corporation
UMLS_CUI: C1551800
Legacy_Concept_Name: Arctic_Slope_Corporation
has exact synonym: Arctic Slope Corporation

Atqasuk
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44670
Semantic_Type: Population Group
Preferred_Name: Atqasuk
UMLS_CUI: C1551801
Legacy_Concept_Name: Atqasuk
has exact synonym: Atqasuk

Barrow
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44671
Semantic_Type: Population Group
Preferred_Name: Barrow
UMLS_CUI: C1551802
Legacy_Concept_Name: Barrow
has exact synonym: Barrow

Bering Straits Inupiat
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44672
Semantic_Type: Population Group
Preferred_Name: Bering Straits Inupiat
UMLS_CUI: C1551803
Legacy_Concept_Name: Bering_Straits_Inupiat
has exact synonym: Bering Straits Inupiat

Brevig Mission
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44673
Semantic_Type: Population Group
Preferred_Name: Brevig Mission
UMLS_CUI: C1551804
Legacy_Concept_Name: Brevig_Mission
has exact synonym: Brevig Mission

Buckland
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44674
Semantic_Type: Population Group
Preferred_Name: Buckland
UMLS_CUI: C1551805
Legacy_Concept_Name: Buckland
has exact synonym: Buckland

Chinik
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44675
Semantic_Type: Population Group
Preferred_Name: Chinik
UMLS_CUI: C1551806
Legacy_Concept_Name: Chinik
has exact synonym: Chinik

Council
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44676
Semantic_Type: Population Group
Preferred_Name: Council
UMLS_CUI: C1551807
Legacy_Concept_Name: Council
has exact synonym: Council

Deering
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44677
Semantic_Type: Population Group
Preferred_Name: Deering
UMLS_CUI: C1551808
Legacy_Concept_Name: Deering
has exact synonym: Deering

Elim
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44678
Semantic_Type: Population Group
Preferred_Name: Elim
UMLS_CUI: C1551809
Legacy_Concept_Name: Elim
has exact synonym: Elim

Golovin
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44679
Semantic_Type: Population Group
Preferred_Name: Golovin
UMLS_CUI: C1551810
Legacy_Concept_Name: Golovin
has exact synonym: Golovin

Inalik Diamede
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44680
Semantic_Type: Population Group
Preferred_Name: Inalik Diamede
UMLS_CUI: C1551811
Legacy_Concept_Name: Inalik_Diamede
has exact synonym: Inalik Diamede
has exact synonym: Inalik Diomede

Inupiaq
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44681
Semantic_Type: Population Group
Preferred_Name: Inupiaq
UMLS_CUI: C1551812
Legacy_Concept_Name: Inupiaq
has exact synonym: Inupiaq

Kaktovik
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44682
Semantic_Type: Population Group
Preferred_Name: Kaktovik
UMLS_CUI: C1551813
Legacy_Concept_Name: Kaktovik
has exact synonym: Kaktovik

Kawerak
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44683
Semantic_Type: Population Group
Preferred_Name: Kawerak
UMLS_CUI: C1551814
Legacy_Concept_Name: Kawerak
has exact synonym: Kawerak

Kiana
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44684
Semantic_Type: Population Group
Preferred_Name: Kiana
UMLS_CUI: C1551815
Legacy_Concept_Name: Kiana
has exact synonym: Kiana

Kivalina
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44685
Semantic_Type: Population Group
Preferred_Name: Kivalina
UMLS_CUI: C1551816
Legacy_Concept_Name: Kivalina
has exact synonym: Kivalina

Kobuk
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44686
Semantic_Type: Population Group
Preferred_Name: Kobuk
UMLS_CUI: C1551817
Legacy_Concept_Name: Kobuk
has exact synonym: Kobuk

Kotzebue
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44687
Semantic_Type: Population Group
Preferred_Name: Kotzebue
UMLS_CUI: C1551818
Legacy_Concept_Name: Kotzebue
has exact synonym: Kotzebue

Koyuk
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44688
Semantic_Type: Population Group
Preferred_Name: Koyuk
UMLS_CUI: C1551819
Legacy_Concept_Name: Koyuk
has exact synonym: Koyuk

Kwiguk
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44689
Semantic_Type: Population Group
Preferred_Name: Kwiguk
UMLS_CUI: C1551820
Legacy_Concept_Name: Kwiguk
has exact synonym: Kwiguk

Mauneluk Inupiat
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44690
Semantic_Type: Population Group
Preferred_Name: Mauneluk Inupiat
UMLS_CUI: C1551821
Legacy_Concept_Name: Mauneluk_Inupiat
has exact synonym: Mauneluk Inupiat

Nana Inupiat
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44691
Semantic_Type: Population Group
Preferred_Name: Nana Inupiat
UMLS_CUI: C1551822
Legacy_Concept_Name: Nana_Inupiat
has exact synonym: Nana Inupiat
has exact synonym: Nana Iñupiat

Noatak
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44692
Semantic_Type: Population Group
Preferred_Name: Noatak
UMLS_CUI: C1551823
Legacy_Concept_Name: Noatak
has exact synonym: Noatak

Nome
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44693
Semantic_Type: Population Group
Preferred_Name: Nome
UMLS_CUI: C1551824
Legacy_Concept_Name: Nome
has exact synonym: Nome

Noorvik
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44694
Semantic_Type: Population Group
Preferred_Name: Noorvik
UMLS_CUI: C1551825
Legacy_Concept_Name: Noorvik
has exact synonym: Noorvik

Nuiqsut
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44695
Semantic_Type: Population Group
Preferred_Name: Nuiqsut
UMLS_CUI: C1551826
Legacy_Concept_Name: Nuiqsut
has exact synonym: Nuiqsut

Point Hope
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44696
Semantic_Type: Population Group
Preferred_Name: Point Hope
UMLS_CUI: C1551827
Legacy_Concept_Name: Point_Hope
has exact synonym: Point Hope

Point Lay
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44697
Semantic_Type: Population Group
Preferred_Name: Point Lay
UMLS_CUI: C1551828
Legacy_Concept_Name: Point_Lay
has exact synonym: Point Lay

Selawik
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44698
Semantic_Type: Population Group
Preferred_Name: Selawik
UMLS_CUI: C1551829
Legacy_Concept_Name: Selawik
has exact synonym: Selawik

Shaktoolik
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44699
Semantic_Type: Population Group
Preferred_Name: Shaktoolik
UMLS_CUI: C1551830
Legacy_Concept_Name: Shaktoolik
has exact synonym: Shaktoolik

Shishmaref
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44700
Semantic_Type: Population Group
Preferred_Name: Shishmaref
UMLS_CUI: C1551831
Legacy_Concept_Name: Shishmaref
has exact synonym: Shishmaref

Shungnak
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44701
Semantic_Type: Population Group
Preferred_Name: Shungnak
UMLS_CUI: C1551832
Legacy_Concept_Name: Shungnak
has exact synonym: Shungnak

Solomon
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44702
Semantic_Type: Population Group
Preferred_Name: Solomon
UMLS_CUI: C1551833
Legacy_Concept_Name: Solomon
has exact synonym: Solomon

Teller
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44703
Semantic_Type: Population Group
Preferred_Name: Teller
UMLS_CUI: C1551834
Legacy_Concept_Name: Teller
has exact synonym: Teller

Unalakleet
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44704
Semantic_Type: Population Group
Preferred_Name: Unalakleet
UMLS_CUI: C1551835
Legacy_Concept_Name: Unalakleet
has exact synonym: Unalakleet

Wainwright
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44705
Semantic_Type: Population Group
Preferred_Name: Wainwright
UMLS_CUI: C1551836
Legacy_Concept_Name: Wainwright
has exact synonym: Wainwright

Wales
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44706
Semantic_Type: Population Group
Preferred_Name: Wales
UMLS_CUI: C1551837
Legacy_Concept_Name: Wales
has exact synonym: Wales

White Mountain
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44707
Semantic_Type: Population Group
Preferred_Name: White Mountain
UMLS_CUI: C1551838
Legacy_Concept_Name: White_Mountain
has exact synonym: White Mountain

White Mountain Inupiat
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44708
Semantic_Type: Population Group
Preferred_Name: White Mountain Inupiat
UMLS_CUI: C1551839
Legacy_Concept_Name: White_Mountain_Inupiat
has exact synonym: White Mountain Inupiat

Mary's Igloo
type: Class
subclass of: Inupiat Eskimo
imported from: ncit.owl
code: C44709
Semantic_Type: Population Group
Preferred_Name: Mary's Igloo
UMLS_CUI: C1551840
Legacy_Concept_Name: Mary_s_Igloo
has exact synonym: Mary's Igloo

Angoon
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44710
Semantic_Type: Population Group
Preferred_Name: Angoon
UMLS_CUI: C1551772
Legacy_Concept_Name: Angoon
has exact synonym: Angoon

Central Council of Tlingit and Haida Tribes
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44711
Semantic_Type: Population Group
Preferred_Name: Central Council of Tlingit and Haida Tribes
UMLS_CUI: C1551773
Legacy_Concept_Name: Central_Council_of_Tlingit_and_Haida_Tribes
has exact synonym: Central Council of Tlingit and Haida Tribes

Chilkat
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44712
Semantic_Type: Population Group
Preferred_Name: Chilkat
UMLS_CUI: C1551774
Legacy_Concept_Name: Chilkat
has exact synonym: Chilkat

Chilkoot
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44713
Semantic_Type: Population Group
Preferred_Name: Chilkoot
UMLS_CUI: C1551775
Legacy_Concept_Name: Chilkoot
has exact synonym: Chilkoot

Craig
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44714
Semantic_Type: Population Group
Preferred_Name: Craig
UMLS_CUI: C1551776
Legacy_Concept_Name: Craig
has exact synonym: Craig

Douglas
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44715
Semantic_Type: Population Group
Preferred_Name: Douglas
UMLS_CUI: C1551777
Legacy_Concept_Name: Douglas
has exact synonym: Douglas

Haida
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44716
Semantic_Type: Population Group
Preferred_Name: Haida
UMLS_CUI: C0682117
Legacy_Concept_Name: Haida
has exact synonym: Haida

Hoonah
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44717
Semantic_Type: Population Group
Preferred_Name: Hoonah
UMLS_CUI: C1551778
Legacy_Concept_Name: Hoonah
has exact synonym: Hoonah

Hydaburg
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44718
Semantic_Type: Population Group
Preferred_Name: Hydaburg
UMLS_CUI: C1551779
Legacy_Concept_Name: Hydaburg
has exact synonym: Hydaburg

Kake
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44719
Semantic_Type: Population Group
Preferred_Name: Kake
UMLS_CUI: C1551780
Legacy_Concept_Name: Kake
has exact synonym: Kake

Kasaan
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44720
Semantic_Type: Population Group
Preferred_Name: Kasaan
UMLS_CUI: C1551781
Legacy_Concept_Name: Kasaan
has exact synonym: Kasaan

Kenaitze
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44721
Semantic_Type: Population Group
Preferred_Name: Kenaitze
UMLS_CUI: C1551782
Legacy_Concept_Name: Kenaitze
has exact synonym: Kenaitze

Ketchikan
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44722
Semantic_Type: Population Group
Preferred_Name: Ketchikan
UMLS_CUI: C1551783
Legacy_Concept_Name: Ketchikan
has exact synonym: Ketchikan

Klawock
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44723
Semantic_Type: Population Group
Preferred_Name: Klawock
UMLS_CUI: C1551784
Legacy_Concept_Name: Klawock
has exact synonym: Klawock

Pelican
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44724
Semantic_Type: Population Group
Preferred_Name: Pelican
UMLS_CUI: C1551785
Legacy_Concept_Name: Pelican
has exact synonym: Pelican

Petersburg
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44725
Semantic_Type: Population Group
Preferred_Name: Petersburg
UMLS_CUI: C1551786
Legacy_Concept_Name: Petersburg
has exact synonym: Petersburg

Saxman
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44726
Semantic_Type: Population Group
Preferred_Name: Saxman
UMLS_CUI: C1551787
Legacy_Concept_Name: Saxman
has exact synonym: Saxman

Sitka
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44727
Semantic_Type: Population Group
Preferred_Name: Sitka
UMLS_CUI: C1551788
Legacy_Concept_Name: Sitka
has exact synonym: Sitka

Tenakee Springs
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44728
Semantic_Type: Population Group
Preferred_Name: Tenakee Springs
UMLS_CUI: C1551789
Legacy_Concept_Name: Tenakee_Springs
has exact synonym: Tenakee Springs

Tlingit
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44729
Semantic_Type: Population Group
Preferred_Name: Tlingit
UMLS_CUI: C0682118
Legacy_Concept_Name: Tlingit
has exact synonym: Tlingit

Wrangell
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44730
Semantic_Type: Population Group
Preferred_Name: Wrangell
UMLS_CUI: C1551790
Legacy_Concept_Name: Wrangell
has exact synonym: Wrangell

Yakutat
type: Class
subclass of: Tlingit-Haida
imported from: ncit.owl
code: C44731
Semantic_Type: Population Group
Preferred_Name: Yakutat
UMLS_CUI: C1551791
Legacy_Concept_Name: Yakutat
has exact synonym: Yakutat

Ahtna
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44732
Semantic_Type: Population Group
Preferred_Name: Ahtna
UMLS_CUI: C1551700
Legacy_Concept_Name: Ahtna
has exact synonym: Ahtna

Alatna
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44733
Semantic_Type: Population Group
Preferred_Name: Alatna
NCI_META_CUI: CL334372
Legacy_Concept_Name: Alatna
has exact synonym: Alatna

Alexander
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44734
Semantic_Type: Population Group
Preferred_Name: Alexander
UMLS_CUI: C1551702
Legacy_Concept_Name: Alexander
has exact synonym: Alexander

Allakaket
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44735
Semantic_Type: Population Group
Preferred_Name: Allakaket
UMLS_CUI: C1551703
Legacy_Concept_Name: Allakaket
has exact synonym: Allakaket

Alanvik
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44736
Semantic_Type: Population Group
Preferred_Name: Alanvik
UMLS_CUI: C1551704
Legacy_Concept_Name: Alanvik
has exact synonym: Alanvik

Anvik
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44737
Semantic_Type: Population Group
Preferred_Name: Anvik
UMLS_CUI: C1551705
Legacy_Concept_Name: Anvik
has exact synonym: Anvik

Arctic
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44738
Semantic_Type: Population Group
Preferred_Name: Arctic
NCI_META_CUI: CL337306
Legacy_Concept_Name: Arctic
has exact synonym: Arctic

Beaver
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44739
Semantic_Type: Population Group
Preferred_Name: Beaver
UMLS_CUI: C1551707
Legacy_Concept_Name: Beaver
has exact synonym: Beaver

Birch Creek
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44740
Semantic_Type: Population Group
Preferred_Name: Birch Creek
UMLS_CUI: C1551708
Legacy_Concept_Name: Birch_Creek
has exact synonym: Birch Creek

Cantwell
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44741
Semantic_Type: Population Group
Preferred_Name: Cantwell
UMLS_CUI: C1551709
Legacy_Concept_Name: Cantwell
has exact synonym: Cantwell

Chalkyitsik
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44742
Semantic_Type: Population Group
Preferred_Name: Chalkyitsik
UMLS_CUI: C1551710
Legacy_Concept_Name: Chalkyitsik
has exact synonym: Chalkyitsik

Chickaloon
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44743
Semantic_Type: Population Group
Preferred_Name: Chickaloon
UMLS_CUI: C1551711
Legacy_Concept_Name: Chickaloon
has exact synonym: Chickaloon

Chistochina
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44744
Semantic_Type: Population Group
Preferred_Name: Chistochina
UMLS_CUI: C1551712
Legacy_Concept_Name: Chistochina
has exact synonym: Chistochina

Chitina
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44745
Semantic_Type: Population Group
Preferred_Name: Chitina
UMLS_CUI: C1551713
Legacy_Concept_Name: Chitina
has exact synonym: Chitina

Circle Tribe
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44746
Semantic_Type: Population Group
Preferred_Name: Circle Tribe
UMLS_CUI: C1551714
Legacy_Concept_Name: Circle_Tribe
has exact synonym: Circle
has exact synonym: Circle Tribe

Cook Inlet
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44747
Semantic_Type: Population Group
Preferred_Name: Cook Inlet
UMLS_CUI: C1551715
Legacy_Concept_Name: Cook_Inlet
has exact synonym: Cook Inlet

Copper Center
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44748
Semantic_Type: Population Group
Preferred_Name: Copper Center
UMLS_CUI: C1551716
Legacy_Concept_Name: Copper_Center
has exact synonym: Copper Center

Copper River
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44749
Semantic_Type: Population Group
Preferred_Name: Copper River
UMLS_CUI: C1551717
Legacy_Concept_Name: Copper_River
has exact synonym: Copper River

Dot Lake
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44750
Semantic_Type: Population Group
Preferred_Name: Dot Lake
UMLS_CUI: C1551718
Legacy_Concept_Name: Dot_Lake
has exact synonym: Dot Lake

Doyon
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44751
Semantic_Type: Population Group
Preferred_Name: Doyon
UMLS_CUI: C1551719
Legacy_Concept_Name: Doyon
has exact synonym: Doyon

Eagle
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44752
Semantic_Type: Population Group
Preferred_Name: Eagle
UMLS_CUI: C1551720
Legacy_Concept_Name: Eagle
has exact synonym: Eagle

Eklutna
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44753
Semantic_Type: Population Group
Preferred_Name: Eklutna
UMLS_CUI: C1551721
Legacy_Concept_Name: Eklutna
has exact synonym: Eklutna

Evansville
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44754
Semantic_Type: Population Group
Preferred_Name: Evansville
UMLS_CUI: C1551722
Legacy_Concept_Name: Evansville
has exact synonym: Evansville

Fort Yukon
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44755
Semantic_Type: Population Group
Preferred_Name: Fort Yukon
UMLS_CUI: C1551723
Legacy_Concept_Name: Fort_Yukon
has exact synonym: Fort Yukon

Gakona
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44756
Semantic_Type: Population Group
Preferred_Name: Gakona
UMLS_CUI: C1551724
Legacy_Concept_Name: Gakona
has exact synonym: Gakona

Galena
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44757
Semantic_Type: Population Group
Preferred_Name: Galena
UMLS_CUI: C1551725
Legacy_Concept_Name: Galena
has exact synonym: Galena

Grayling
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44758
Semantic_Type: Population Group
Preferred_Name: Grayling
UMLS_CUI: C1551726
Legacy_Concept_Name: Grayling
has exact synonym: Grayling

Gulkana
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44759
Semantic_Type: Population Group
Preferred_Name: Gulkana
UMLS_CUI: C1551727
Legacy_Concept_Name: Gulkana
has exact synonym: Gulkana

Healy Lake
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44760
Semantic_Type: Population Group
Preferred_Name: Healy Lake
UMLS_CUI: C1551728
Legacy_Concept_Name: Healy_Lake
has exact synonym: Healy Lake

Holy Cross
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44761
Semantic_Type: Population Group
Preferred_Name: Holy Cross
UMLS_CUI: C1551729
Legacy_Concept_Name: Holy_Cross
has exact synonym: Holy Cross

Hughes
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44762
Semantic_Type: Population Group
Preferred_Name: Hughes
UMLS_CUI: C1551730
Legacy_Concept_Name: Hughes
has exact synonym: Hughes

Huslia
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44763
Semantic_Type: Population Group
Preferred_Name: Huslia
UMLS_CUI: C1551731
Legacy_Concept_Name: Huslia
has exact synonym: Huslia

Iliamna
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44764
Semantic_Type: Population Group
Preferred_Name: Iliamna
UMLS_CUI: C1551732
Legacy_Concept_Name: Iliamna
has exact synonym: Iliamna

Kaltag
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44765
Semantic_Type: Population Group
Preferred_Name: Kaltag
UMLS_CUI: C1551733
Legacy_Concept_Name: Kaltag
has exact synonym: Kaltag

Kluti Kaah
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44766
Semantic_Type: Population Group
Preferred_Name: Kluti Kaah
UMLS_CUI: C1551734
Legacy_Concept_Name: Kluti_Kaah
has exact synonym: Kluti Kaah

Knik
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44767
Semantic_Type: Population Group
Preferred_Name: Knik
UMLS_CUI: C1551735
Legacy_Concept_Name: Knik
has exact synonym: Knik

Koyukuk
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44768
Semantic_Type: Population Group
Preferred_Name: Koyukuk
UMLS_CUI: C1551736
Legacy_Concept_Name: Koyukuk
has exact synonym: Koyukuk

Lake Minchumina
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44769
Semantic_Type: Population Group
Preferred_Name: Lake Minchumina
UMLS_CUI: C1551737
Legacy_Concept_Name: Lake_Minchumina
has exact synonym: Lake Minchumina

Lime
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44770
Semantic_Type: Population Group
Preferred_Name: Lime
UMLS_CUI: C1551738
Legacy_Concept_Name: Lime
has exact synonym: Lime

Mcgrath
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44771
Semantic_Type: Population Group
Preferred_Name: Mcgrath
UMLS_CUI: C1551739
Legacy_Concept_Name: Mcgrath
has exact synonym: Mcgrath

Manley Hot Springs
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44772
Semantic_Type: Population Group
Preferred_Name: Manley Hot Springs
UMLS_CUI: C1551740
Legacy_Concept_Name: Manley_Hot_Springs
has exact synonym: Manley Hot Springs

Mentasta Lake
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44773
Semantic_Type: Population Group
Preferred_Name: Mentasta Lake
UMLS_CUI: C1551741
Legacy_Concept_Name: Mentasta_Lake
has exact synonym: Mentasta Lake

Minto
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44774
Semantic_Type: Population Group
Preferred_Name: Minto
NCI_META_CUI: CL334407
Legacy_Concept_Name: Minto
has exact synonym: Minto

Nenana
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44775
Semantic_Type: Population Group
Preferred_Name: Nenana
UMLS_CUI: C1551743
Legacy_Concept_Name: Nenana
has exact synonym: Nenana

Nikolai
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44776
Semantic_Type: Population Group
Preferred_Name: Nikolai
UMLS_CUI: C1551744
Legacy_Concept_Name: Nikolai
has exact synonym: Nikolai

Ninilchik
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44777
Semantic_Type: Population Group
Preferred_Name: Ninilchik
UMLS_CUI: C1551745
Legacy_Concept_Name: Ninilchik
has exact synonym: Ninilchik

Nondalton
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44778
Semantic_Type: Population Group
Preferred_Name: Nondalton
UMLS_CUI: C1551746
Legacy_Concept_Name: Nondalton
has exact synonym: Nondalton

Northway
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44779
Semantic_Type: Population Group
Preferred_Name: Northway
UMLS_CUI: C1551747
Legacy_Concept_Name: Northway
has exact synonym: Northway

Nulato
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44780
Semantic_Type: Population Group
Preferred_Name: Nulato
UMLS_CUI: C1551748
Legacy_Concept_Name: Nulato
has exact synonym: Nulato

Pedro Bay
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44781
Semantic_Type: Population Group
Preferred_Name: Pedro Bay
UMLS_CUI: C1551749
Legacy_Concept_Name: Pedro_Bay
has exact synonym: Pedro Bay

Rampart
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44782
Semantic_Type: Population Group
Preferred_Name: Rampart
UMLS_CUI: C1551750
Legacy_Concept_Name: Rampart
has exact synonym: Rampart

Ruby
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44783
Semantic_Type: Population Group
Preferred_Name: Ruby
UMLS_CUI: C1551751
Legacy_Concept_Name: Ruby
has exact synonym: Ruby

Salamatof
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44784
Semantic_Type: Population Group
Preferred_Name: Salamatof
NCI_META_CUI: CL334417
Legacy_Concept_Name: Salamatof
has exact synonym: Salamatof

Seldovia
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44785
Semantic_Type: Population Group
Preferred_Name: Seldovia
UMLS_CUI: C1551753
Legacy_Concept_Name: Seldovia
has exact synonym: Seldovia

Slana
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44786
Semantic_Type: Population Group
Preferred_Name: Slana
UMLS_CUI: C1551754
Legacy_Concept_Name: Slana
has exact synonym: Slana

Shageluk
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44787
Semantic_Type: Population Group
Preferred_Name: Shageluk
UMLS_CUI: C1551755
Legacy_Concept_Name: Shageluk
has exact synonym: Shageluk

Stevens
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44788
Semantic_Type: Population Group
Preferred_Name: Stevens
NCI_META_CUI: CL334421
Legacy_Concept_Name: Stevens
has exact synonym: Stevens

Stony River
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44789
Semantic_Type: Population Group
Preferred_Name: Stony River
UMLS_CUI: C1551757
Legacy_Concept_Name: Stony_River
has exact synonym: Stony River

Takotna
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44790
Semantic_Type: Population Group
Preferred_Name: Takotna
UMLS_CUI: C1551758
Legacy_Concept_Name: Takotna
has exact synonym: Takotna

Tanacross
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44791
Semantic_Type: Population Group
Preferred_Name: Tanacross
UMLS_CUI: C1551759
Legacy_Concept_Name: Tanacross
has exact synonym: Tanacross

Tanaina
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44792
Semantic_Type: Population Group
Preferred_Name: Tanaina
UMLS_CUI: C1551760
Legacy_Concept_Name: Tanaina
has exact synonym: Tanaina

Tanana
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44793
Semantic_Type: Population Group
Preferred_Name: Tanana
UMLS_CUI: C1551761
Legacy_Concept_Name: Tanana
has exact synonym: Tanana

Tanana Chiefs
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44794
Semantic_Type: Population Group
Preferred_Name: Tanana Chiefs
UMLS_CUI: C1551762
Legacy_Concept_Name: Tanana_Chiefs
has exact synonym: Tanana Chiefs

Tazlina
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44795
Semantic_Type: Population Group
Preferred_Name: Tazlina
NCI_META_CUI: CL334428
Legacy_Concept_Name: Tazlina
has exact synonym: Tazlina

Telida
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44796
Semantic_Type: Population Group
Preferred_Name: Telida
UMLS_CUI: C1551764
Legacy_Concept_Name: Telida
has exact synonym: Telida

Tetlin
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44797
Semantic_Type: Population Group
Preferred_Name: Tetlin
UMLS_CUI: C1551765
Legacy_Concept_Name: Tetlin
has exact synonym: Tetlin

Tok
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44798
Semantic_Type: Population Group
Preferred_Name: Tok
UMLS_CUI: C1551766
Legacy_Concept_Name: Tok
has exact synonym: Tok

Tyonek
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44799
Semantic_Type: Population Group
Preferred_Name: Tyonek
UMLS_CUI: C1551767
Legacy_Concept_Name: Tyonek
has exact synonym: Tyonek

Venetie
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44800
Semantic_Type: Population Group
Preferred_Name: Venetie
UMLS_CUI: C1551768
Legacy_Concept_Name: Venetie
has exact synonym: Venetie

Wiseman
type: Class
subclass of: Alaskan Athabascan
imported from: ncit.owl
code: C44801
Semantic_Type: Population Group
Preferred_Name: Wiseman
UMLS_CUI: C1551769
Legacy_Concept_Name: Wiseman
has exact synonym: Wiseman

Duwamish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44802
Semantic_Type: Population Group
Preferred_Name: Duwamish
UMLS_CUI: C1551540
Legacy_Concept_Name: Duwamish
has exact synonym: Duwamish

Kikiallus
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44803
Semantic_Type: Population Group
Preferred_Name: Kikiallus
UMLS_CUI: C1551541
Legacy_Concept_Name: Kikiallus
has exact synonym: Kikiallus

Lower Skagit
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44804
Semantic_Type: Population Group
Preferred_Name: Lower Skagit
UMLS_CUI: C1551542
Legacy_Concept_Name: Lower_Skagit
has exact synonym: Lower Skagit

Muckleshoot
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44805
Semantic_Type: Population Group
Preferred_Name: Muckleshoot
UMLS_CUI: C1551543
Legacy_Concept_Name: Muckleshoot
has exact synonym: Muckleshoot

Nisqually
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44806
Semantic_Type: Population Group
Preferred_Name: Nisqually
UMLS_CUI: C1551544
Legacy_Concept_Name: Nisqually
has exact synonym: Nisqually

Nooksack
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44807
Semantic_Type: Population Group
Preferred_Name: Nooksack
UMLS_CUI: C1551545
Legacy_Concept_Name: Nooksack
has exact synonym: Nooksack

Port Madison
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44808
Semantic_Type: Population Group
Preferred_Name: Port Madison
UMLS_CUI: C1551546
Legacy_Concept_Name: Port_Madison
has exact synonym: Port Madison

Puyallup
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44809
Semantic_Type: Population Group
Preferred_Name: Puyallup
UMLS_CUI: C1551547
Legacy_Concept_Name: Puyallup
has exact synonym: Puyallup

Samish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44810
Semantic_Type: Population Group
Preferred_Name: Samish
UMLS_CUI: C1551548
Legacy_Concept_Name: Samish
has exact synonym: Samish

Sauk-Suiattle
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44811
Semantic_Type: Population Group
Preferred_Name: Sauk-Suiattle
UMLS_CUI: C1551549
Legacy_Concept_Name: Sauk-Suiattle
has exact synonym: Sauk-Suiattle

Skokomish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44812
Semantic_Type: Population Group
Preferred_Name: Skokomish
UMLS_CUI: C1551550
Legacy_Concept_Name: Skokomish
has exact synonym: Skokomish

Skykomish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44813
Semantic_Type: Population Group
Preferred_Name: Skykomish
UMLS_CUI: C1551551
Legacy_Concept_Name: Skykomish
has exact synonym: Skykomish

Snohomish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44814
Semantic_Type: Population Group
Preferred_Name: Snohomish
UMLS_CUI: C1551552
Legacy_Concept_Name: Snohomish
has exact synonym: Snohomish

Snoqualmie
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44815
Semantic_Type: Population Group
Preferred_Name: Snoqualmie
UMLS_CUI: C1551553
Legacy_Concept_Name: Snoqualmie
has exact synonym: Snoqualmie

Squaxin Island
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44816
Semantic_Type: Population Group
Preferred_Name: Squaxin Island
UMLS_CUI: C1551554
Legacy_Concept_Name: Squaxin_Island
has exact synonym: Squaxin Island

Steilacoom
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44817
Semantic_Type: Population Group
Preferred_Name: Steilacoom
UMLS_CUI: C1551555
Legacy_Concept_Name: Steilacoom
has exact synonym: Steilacoom

Stillaguamish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44818
Semantic_Type: Population Group
Preferred_Name: Stillaguamish
UMLS_CUI: C1551556
Legacy_Concept_Name: Stillaguamish
has exact synonym: Stillaguamish

Suquamish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44819
Semantic_Type: Population Group
Preferred_Name: Suquamish
UMLS_CUI: C1551557
Legacy_Concept_Name: Suquamish
has exact synonym: Suquamish

Swinomish
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44820
Semantic_Type: Population Group
Preferred_Name: Swinomish
UMLS_CUI: C1551558
Legacy_Concept_Name: Swinomish
has exact synonym: Swinomish

Tulalip
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44821
Semantic_Type: Population Group
Preferred_Name: Tulalip
UMLS_CUI: C1551559
Legacy_Concept_Name: Tulalip
has exact synonym: Tulalip

Upper Skagit
type: Class
subclass of: Puget Sound Salish
imported from: ncit.owl
code: C44822
Semantic_Type: Population Group
Preferred_Name: Upper Skagit
UMLS_CUI: C1551560
Legacy_Concept_Name: Upper_Skagit
has exact synonym: Upper Skagit

Acoma
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44823
Semantic_Type: Population Group
Preferred_Name: Acoma
UMLS_CUI: C1551514
Legacy_Concept_Name: Acoma
has exact synonym: Acoma

Arizona Tewa
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44824
Semantic_Type: Population Group
Preferred_Name: Arizona Tewa
UMLS_CUI: C1551515
Legacy_Concept_Name: Arizona_Tewa
has exact synonym: Arizona Tewa

Cochiti
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44825
Semantic_Type: Population Group
Preferred_Name: Cochiti
UMLS_CUI: C1551516
Legacy_Concept_Name: Cochiti
has exact synonym: Cochiti

Hopi
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44826
Semantic_Type: Population Group
Preferred_Name: Hopi
UMLS_CUI: C0682111
Legacy_Concept_Name: Hopi
has exact synonym: Hopi

Isleta
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44827
Semantic_Type: Population Group
Preferred_Name: Isleta
UMLS_CUI: C1551517
Legacy_Concept_Name: Isleta
has exact synonym: Isleta

Jemez
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44828
Semantic_Type: Population Group
Preferred_Name: Jemez
UMLS_CUI: C1551518
Legacy_Concept_Name: Jemez
has exact synonym: Jemez

Keres
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44829
Semantic_Type: Population Group
Preferred_Name: Keres
UMLS_CUI: C1551519
Legacy_Concept_Name: Keres
has exact synonym: Keres

Laguna
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44830
Semantic_Type: Population Group
Preferred_Name: Laguna
UMLS_CUI: C1551520
Legacy_Concept_Name: Laguna
has exact synonym: Laguna

Nambe
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44831
Semantic_Type: Population Group
Preferred_Name: Nambe
UMLS_CUI: C1551521
Legacy_Concept_Name: Nambe
has exact synonym: Nambe

Picuris
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44832
Semantic_Type: Population Group
Preferred_Name: Picuris
UMLS_CUI: C1551522
Legacy_Concept_Name: Picuris
has exact synonym: Picuris

Piro
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44833
Semantic_Type: Population Group
Preferred_Name: Piro
UMLS_CUI: C1551523
Legacy_Concept_Name: Piro
has exact synonym: Piro

Pojoaque
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44834
Semantic_Type: Population Group
Preferred_Name: Pojoaque
UMLS_CUI: C1551524
Legacy_Concept_Name: Pojoaque
has exact synonym: Pojoaque

San Felipe
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44835
Semantic_Type: Population Group
Preferred_Name: San Felipe
UMLS_CUI: C1551525
Legacy_Concept_Name: San_Felipe
has exact synonym: San Felipe

San Ildefonso
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44836
Semantic_Type: Population Group
Preferred_Name: San Ildefonso
UMLS_CUI: C1551526
Legacy_Concept_Name: San_Ildefonso
has exact synonym: San Ildefonso

San Juan Pueblo
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44837
Semantic_Type: Population Group
Preferred_Name: San Juan Pueblo
UMLS_CUI: C1551527
Legacy_Concept_Name: San_Juan_Pueblo
has exact synonym: San Juan Pueblo

San Juan De
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44838
Semantic_Type: Population Group
Preferred_Name: San Juan De
UMLS_CUI: C1551528
Legacy_Concept_Name: San_Juan_De
has exact synonym: San Juan De

San Juan
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44839
Semantic_Type: Population Group
Preferred_Name: San Juan
UMLS_CUI: C1551529
Legacy_Concept_Name: San_Juan
has exact synonym: San Juan

Sandia
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44840
Semantic_Type: Population Group
Preferred_Name: Sandia
UMLS_CUI: C1551530
Legacy_Concept_Name: Sandia
has exact synonym: Sandia

Santa Ana
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44841
Semantic_Type: Population Group
Preferred_Name: Santa Ana
UMLS_CUI: C1551531
Legacy_Concept_Name: Santa_Ana
has exact synonym: Santa Ana

Santa Clara
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44842
Semantic_Type: Population Group
Preferred_Name: Santa Clara
UMLS_CUI: C1551532
Legacy_Concept_Name: Santa_Clara
has exact synonym: Santa Clara

Santo Domingo
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44843
Semantic_Type: Population Group
Preferred_Name: Santo Domingo
UMLS_CUI: C1551533
Legacy_Concept_Name: Santo_Domingo
has exact synonym: Santo Domingo

Taos
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44844
Semantic_Type: Population Group
Preferred_Name: Taos
UMLS_CUI: C1551534
Legacy_Concept_Name: Taos
has exact synonym: Taos

Tesuque
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44845
Semantic_Type: Population Group
Preferred_Name: Tesuque
UMLS_CUI: C1551535
Legacy_Concept_Name: Tesuque
has exact synonym: Tesuque

Tewa
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44846
Semantic_Type: Population Group
Preferred_Name: Tewa
UMLS_CUI: C1551536
Legacy_Concept_Name: Tewa
has exact synonym: Tewa

Tigua
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44847
Semantic_Type: Population Group
Preferred_Name: Tigua
UMLS_CUI: C1551537
Legacy_Concept_Name: Tigua
has exact synonym: Tigua

Zia
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44848
Semantic_Type: Population Group
Preferred_Name: Zia
UMLS_CUI: C1551538
Legacy_Concept_Name: Zia
has exact synonym: Zia

Zuni
type: Class
subclass of: Pueblo
imported from: ncit.owl
code: C44849
Semantic_Type: Population Group
Preferred_Name: Zuni
UMLS_CUI: C0682110
Legacy_Concept_Name: Zuni
has exact synonym: Zuni
has exact synonym: Zuñi

Citzen Band Potawatomi
type: Class
subclass of: Potawatomi
imported from: ncit.owl
code: C44850
Semantic_Type: Population Group
Preferred_Name: Citzen Band Potawatomi
UMLS_CUI: C1551506
Legacy_Concept_Name: Citzen_Band_Potawatomi
has exact synonym: Citizen Band Potawatomi
has exact synonym: Citzen Band Potawatomi

Forest County
type: Class
subclass of: Potawatomi
imported from: ncit.owl
code: C44851
Semantic_Type: Population Group
Preferred_Name: Forest County
UMLS_CUI: C1551507
Legacy_Concept_Name: Forest_County
has exact synonym: Forest County

Hannahville
type: Class
subclass of: Potawatomi
imported from: ncit.owl
code: C44852
Semantic_Type: Population Group
Preferred_Name: Hannahville
UMLS_CUI: C1551508
Legacy_Concept_Name: Hannahville
has exact synonym: Hannahville

Huron Potawatomi
type: Class
subclass of: Potawatomi
imported from: ncit.owl
code: C44853
Semantic_Type: Population Group
Preferred_Name: Huron Potawatomi
UMLS_CUI: C1551509
Legacy_Concept_Name: Huron_Potawatomi
has exact synonym: Huron Potawatomi

Pokagon Potawatomi
type: Class
subclass of: Potawatomi
imported from: ncit.owl
code: C44854
Semantic_Type: Population Group
Preferred_Name: Pokagon Potawatomi
UMLS_CUI: C1551510
Legacy_Concept_Name: Pokagon_Potawatomi
has exact synonym: Pokagon Potawatomi

Prairie Band
type: Class
subclass of: Potawatomi
imported from: ncit.owl
code: C44855
Semantic_Type: Population Group
Preferred_Name: Prairie Band
UMLS_CUI: C1551511
Legacy_Concept_Name: Prairie_Band
has exact synonym: Prairie Band

Wisconsin Potawatomi
type: Class
subclass of: Potawatomi
imported from: ncit.owl
code: C44856
Semantic_Type: Population Group
Preferred_Name: Wisconsin Potawatomi
UMLS_CUI: C1551512
Legacy_Concept_Name: Wisconsin_Potawatomi
has exact synonym: Wisconsin Potawatomi

Central Pomo
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44857
Semantic_Type: Population Group
Preferred_Name: Central Pomo
UMLS_CUI: C1551494
Legacy_Concept_Name: Central_Pomo
has exact synonym: Central Pomo

Dry Creek
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44858
Semantic_Type: Population Group
Preferred_Name: Dry Creek
UMLS_CUI: C1551495
Legacy_Concept_Name: Dry_Creek
has exact synonym: Dry Creek

Eastern Pomo
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44859
Semantic_Type: Population Group
Preferred_Name: Eastern Pomo
UMLS_CUI: C1551496
Legacy_Concept_Name: Eastern_Pomo
has exact synonym: Eastern Pomo

Kashia
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44860
Semantic_Type: Population Group
Preferred_Name: Kashia
UMLS_CUI: C1551497
Legacy_Concept_Name: Kashia
has exact synonym: Kashia

Northern Pomo
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44861
Semantic_Type: Population Group
Preferred_Name: Northern Pomo
UMLS_CUI: C1551498
Legacy_Concept_Name: Northern_Pomo
has exact synonym: Northern Pomo

Scotts Valley
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44862
Semantic_Type: Population Group
Preferred_Name: Scotts Valley
UMLS_CUI: C1551499
Legacy_Concept_Name: Scotts_Valley
has exact synonym: Scotts Valley

Stonyford
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44863
Semantic_Type: Population Group
Preferred_Name: Stonyford
UMLS_CUI: C1551500
Legacy_Concept_Name: Stonyford
has exact synonym: Stonyford

Sulphur Bank
type: Class
subclass of: Pomo
imported from: ncit.owl
code: C44864
Semantic_Type: Population Group
Preferred_Name: Sulphur Bank
UMLS_CUI: C1551501
Legacy_Concept_Name: Sulphur_Bank
has exact synonym: Sulphur Bank

Cayuga
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44865
Semantic_Type: Population Group
Preferred_Name: Cayuga
UMLS_CUI: C1555234
Legacy_Concept_Name: Cayuga
has exact synonym: Cayuga

Mohawk
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44866
Semantic_Type: Population Group
Preferred_Name: Mohawk
UMLS_CUI: C0682099
Legacy_Concept_Name: Mohawk
has exact synonym: Mohawk

Oneida
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44867
Semantic_Type: Population Group
Preferred_Name: Oneida
UMLS_CUI: C1555235
Legacy_Concept_Name: Oneida
has exact synonym: Oneida

Onondaga
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44868
Semantic_Type: Population Group
Preferred_Name: Onondaga
UMLS_CUI: C1555236
Legacy_Concept_Name: Onondaga
has exact synonym: Onondaga

Seneca
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44869
Semantic_Type: Population Group
Preferred_Name: Seneca
UMLS_CUI: C1555237
Legacy_Concept_Name: Seneca
has exact synonym: Seneca

Seneca Nation
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44870
Semantic_Type: Population Group
Preferred_Name: Seneca Nation
UMLS_CUI: C1555238
Legacy_Concept_Name: Seneca_Nation
has exact synonym: Seneca Nation

Seneca-Cayuga
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44871
Semantic_Type: Population Group
Preferred_Name: Seneca-Cayuga
UMLS_CUI: C1555239
Legacy_Concept_Name: Seneca-Cayuga
has exact synonym: Seneca-Cayuga

Tonawanda Seneca
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44872
Semantic_Type: Population Group
Preferred_Name: Tonawanda Seneca
UMLS_CUI: C1555240
Legacy_Concept_Name: Tonawanda_Seneca
has exact synonym: Tonawanda Seneca

Tuscarora
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44873
Semantic_Type: Population Group
Preferred_Name: Tuscarora
UMLS_CUI: C1555241
Legacy_Concept_Name: Tuscarora
has exact synonym: Tuscarora

Wyandotte
type: Class
subclass of: Iroquois
imported from: ncit.owl
code: C44874
Semantic_Type: Population Group
Preferred_Name: Wyandotte
UMLS_CUI: C1555242
Legacy_Concept_Name: Wyandotte
has exact synonym: Wyandotte

Attacapa
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44875
Semantic_Type: Population Group
Preferred_Name: Attacapa
UMLS_CUI: C1555199
Legacy_Concept_Name: Attacapa
has exact synonym: Attacapa

Biloxi
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44876
Semantic_Type: Population Group
Preferred_Name: Biloxi
UMLS_CUI: C1555200
Legacy_Concept_Name: Biloxi
has exact synonym: Biloxi

Moor
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44877
Semantic_Type: Population Group
Preferred_Name: Moor
UMLS_CUI: C1555202
Legacy_Concept_Name: Moor
has exact synonym: Moor

Nansemond
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44878
Semantic_Type: Population Group
Preferred_Name: Nansemond
UMLS_CUI: C1555203
Legacy_Concept_Name: Nansemond
has exact synonym: Nansemond

Natchez
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44879
Semantic_Type: Population Group
Preferred_Name: Natchez
UMLS_CUI: C1555204
Legacy_Concept_Name: Natchez
has exact synonym: Natchez

Nausu Waiwash
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44880
Semantic_Type: Population Group
Preferred_Name: Nausu Waiwash
UMLS_CUI: C1555205
Legacy_Concept_Name: Nausu_Waiwash
has exact synonym: Nausu Waiwash

Nipmuc
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44881
Semantic_Type: Population Group
Preferred_Name: Nipmuc
UMLS_CUI: C1555206
Legacy_Concept_Name: Nipmuc
has exact synonym: Nipmuc

Paugussett
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44882
Semantic_Type: Population Group
Preferred_Name: Paugussett
UMLS_CUI: C1555207
Legacy_Concept_Name: Paugussett
has exact synonym: Paugussett

Pocomoke Acohonock
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44883
Semantic_Type: Population Group
Preferred_Name: Pocomoke Acohonock
UMLS_CUI: C1555208
Legacy_Concept_Name: Pocomoke_Acohonock
has exact synonym: Pocomoke Acohonock

Southeastern Indians
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44884
Semantic_Type: Population Group
Preferred_Name: Southeastern Indians
UMLS_CUI: C1555209
Legacy_Concept_Name: Southeastern_Indians
has exact synonym: Southeastern Indians

Susquehanock
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44885
Semantic_Type: Population Group
Preferred_Name: Susquehanock
UMLS_CUI: C1555210
Legacy_Concept_Name: Susquehanock
has exact synonym: Susquehanock

Tunica Biloxi
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44886
Semantic_Type: Population Group
Preferred_Name: Tunica Biloxi
UMLS_CUI: C1555211
Legacy_Concept_Name: Tunica_Biloxi
has exact synonym: Tunica Biloxi

Waccamaw Siousan
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44887
Semantic_Type: Population Group
Preferred_Name: Waccamaw Siousan
UMLS_CUI: C1555212
Legacy_Concept_Name: Waccamaw_Siousan
has exact synonym: Waccamaw Siousan

Wicomico
type: Class
subclass of: Eastern Tribes
imported from: ncit.owl
code: C44888
Semantic_Type: Population Group
Preferred_Name: Wicomico
UMLS_CUI: C1555213
Legacy_Concept_Name: Wicomico
has exact synonym: Wicomico

Eastern Delaware
type: Class
subclass of: Deleware Indian
imported from: ncit.owl
code: C44889
Semantic_Type: Population Group
Preferred_Name: Eastern Delaware
UMLS_CUI: C1555183
Legacy_Concept_Name: Eastern_Delaware
has exact synonym: Eastern Delaware

Lenni Lenape
type: Class
subclass of: Deleware Indian
imported from: ncit.owl
code: C44890
Semantic_Type: Population Group
Preferred_Name: Lenni Lenape
UMLS_CUI: C1555184
Legacy_Concept_Name: Lenni_Lenape
has exact synonym: Lenni Lenape

Munsee
type: Class
subclass of: Deleware Indian
imported from: ncit.owl
code: C44891
Semantic_Type: Population Group
Preferred_Name: Munsee
UMLS_CUI: C1555185
Legacy_Concept_Name: Munsee
has exact synonym: Munsee

Oklahoma Delaware
type: Class
subclass of: Deleware Indian
imported from: ncit.owl
code: C44892
Semantic_Type: Population Group
Preferred_Name: Oklahoma Delaware
UMLS_CUI: C1555186
Legacy_Concept_Name: Oklahoma_Delaware
has exact synonym: Oklahoma Delaware

Rampough Mountain
type: Class
subclass of: Deleware Indian
imported from: ncit.owl
code: C44893
Semantic_Type: Population Group
Preferred_Name: Rampough Mountain
UMLS_CUI: C1555187
Legacy_Concept_Name: Rampough_Mountain
has exact synonym: Rampough Mountain

Sand Hill
type: Class
subclass of: Deleware Indian
imported from: ncit.owl
code: C44894
Semantic_Type: Population Group
Preferred_Name: Sand Hill
UMLS_CUI: C1555188
Legacy_Concept_Name: Sand_Hill
has exact synonym: Sand Hill

Alabama Creek
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44895
Semantic_Type: Population Group
Preferred_Name: Alabama Creek
UMLS_CUI: C1555166
Legacy_Concept_Name: Alabama_Creek
has exact synonym: Alabama Creek

Alabama Quassarte
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44896
Semantic_Type: Population Group
Preferred_Name: Alabama Quassarte
UMLS_CUI: C1555167
Legacy_Concept_Name: Alabama_Quassarte
has exact synonym: Alabama Quassarte

Eastern Creek
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44897
Semantic_Type: Population Group
Preferred_Name: Eastern Creek
UMLS_CUI: C1555168
Legacy_Concept_Name: Eastern_Creek
has exact synonym: Eastern Creek

Eastern Muscogee
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44898
Semantic_Type: Population Group
Preferred_Name: Eastern Muscogee
UMLS_CUI: C1555169
Legacy_Concept_Name: Eastern_Muscogee
has exact synonym: Eastern Muscogee

Kialegee
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44899
Semantic_Type: Population Group
Preferred_Name: Kialegee
UMLS_CUI: C1555170
Legacy_Concept_Name: Kialegee
has exact synonym: Kialegee

Lower Muscogee
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44900
Semantic_Type: Population Group
Preferred_Name: Lower Muscogee
UMLS_CUI: C1555171
Legacy_Concept_Name: Lower_Muscogee
has exact synonym: Lower Muscogee

Machis Lower Creek Indian
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44901
Semantic_Type: Population Group
Preferred_Name: Machis Lower Creek Indian
UMLS_CUI: C1555172
Legacy_Concept_Name: Machis_Lower_Creek_Indian
has exact synonym: Machis Lower Creek Indian

Poarch Band
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44902
Semantic_Type: Population Group
Preferred_Name: Poarch Band
UMLS_CUI: C1555173
Legacy_Concept_Name: Poarch_Band
has exact synonym: Poarch Band

Principal Creek Indian Nation
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44903
Semantic_Type: Population Group
Preferred_Name: Principal Creek Indian Nation
UMLS_CUI: C1555174
Legacy_Concept_Name: Principal_Creek_Indian_Nation
has exact synonym: Principal Creek Indian Nation

Star Clan of Muscogee Creeks
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44904
Semantic_Type: Population Group
Preferred_Name: Star Clan of Muscogee Creeks
UMLS_CUI: C1555175
Legacy_Concept_Name: Star_Clan_of_Muscogee_Creeks
has exact synonym: Star Clan of Muscogee Creeks

Thlopthlocco
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44905
Semantic_Type: Population Group
Preferred_Name: Thlopthlocco
UMLS_CUI: C1555176
Legacy_Concept_Name: Thlopthlocco
has exact synonym: Thlopthlocco

Tuckabachee
type: Class
subclass of: Creek
imported from: ncit.owl
code: C44906
Semantic_Type: Population Group
Preferred_Name: Tuckabachee
UMLS_CUI: C1555177
Legacy_Concept_Name: Tuckabachee
has exact synonym: Tuckabachee

Bad River
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44907
Semantic_Type: Population Group
Preferred_Name: Bad River
UMLS_CUI: C1555119
Legacy_Concept_Name: Bad_River
has exact synonym: Bad River

Bay Mills Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44908
Semantic_Type: Population Group
Preferred_Name: Bay Mills Chippewa
UMLS_CUI: C1555120
Legacy_Concept_Name: Bay_Mills_Chippewa
has exact synonym: Bay Mills Chippewa

Bois Forte
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44909
Semantic_Type: Population Group
Preferred_Name: Bois Forte
UMLS_CUI: C1555121
Legacy_Concept_Name: Bois_Forte
has exact synonym: Bois Forte

Burt Lake Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44910
Semantic_Type: Population Group
Preferred_Name: Burt Lake Chippewa
UMLS_CUI: C1555122
Legacy_Concept_Name: Burt_Lake_Chippewa
has exact synonym: Burt Lake Chippewa

Fond du Lac
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44911
Semantic_Type: Population Group
Preferred_Name: Fond du Lac
UMLS_CUI: C1555123
Legacy_Concept_Name: Fond_du_Lac
has exact synonym: Fond du Lac

Grand Portage
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44912
Semantic_Type: Population Group
Preferred_Name: Grand Portage
UMLS_CUI: C1555124
Legacy_Concept_Name: Grand_Portage
has exact synonym: Grand Portage

Grand Traverse Band of Ottawa Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44913
Semantic_Type: Population Group
Preferred_Name: Grand Traverse Band of Ottawa Chippewa
UMLS_CUI: C1555125
Legacy_Concept_Name: Grand_Traverse_Band_of_Ottawa_Chippewa
has exact synonym: Grand Traverse Band of Ottawa Chippewa

Keweenaw
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44914
Semantic_Type: Population Group
Preferred_Name: Keweenaw
UMLS_CUI: C1555126
Legacy_Concept_Name: Keweenaw
has exact synonym: Keweenaw

Lac Courte Oreilles
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44915
Semantic_Type: Population Group
Preferred_Name: Lac Courte Oreilles
UMLS_CUI: C1555127
Legacy_Concept_Name: Lac_Courte_Oreilles
has exact synonym: Lac Courte Oreilles

Lac du Flambeau
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44916
Semantic_Type: Population Group
Preferred_Name: Lac du Flambeau
UMLS_CUI: C1555128
Legacy_Concept_Name: Lac_du_Flambeau
has exact synonym: Lac du Flambeau

Lac Vieux Desert Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44917
Semantic_Type: Population Group
Preferred_Name: Lac Vieux Desert Chippewa
UMLS_CUI: C1555129
Legacy_Concept_Name: Lac_Vieux_Desert_Chippewa
has exact synonym: Lac Vieux Desert Chippewa

Lake Superior
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44918
Semantic_Type: Population Group
Preferred_Name: Lake Superior
UMLS_CUI: C1555130
Legacy_Concept_Name: Lake_Superior
has exact synonym: Lake Superior

Leech Lake
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44919
Semantic_Type: Population Group
Preferred_Name: Leech Lake
UMLS_CUI: C1555131
Legacy_Concept_Name: Leech_Lake
has exact synonym: Leech Lake

Little Shell Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44920
Semantic_Type: Population Group
Preferred_Name: Little Shell Chippewa
UMLS_CUI: C1555132
Legacy_Concept_Name: Little_Shell_Chippewa
has exact synonym: Little Shell Chippewa

Mille Lacs
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44921
Semantic_Type: Population Group
Preferred_Name: Mille Lacs
UMLS_CUI: C1555133
Legacy_Concept_Name: Mille_Lacs
has exact synonym: Mille Lacs

Minnesota Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44922
Semantic_Type: Population Group
Preferred_Name: Minnesota Chippewa
UMLS_CUI: C1555134
Legacy_Concept_Name: Minnesota_Chippewa
has exact synonym: Minnesota Chippewa

Ontonagon
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44923
Semantic_Type: Population Group
Preferred_Name: Ontonagon
UMLS_CUI: C1555135
Legacy_Concept_Name: Ontonagon
has exact synonym: Ontonagon

Red Cliff Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44924
Semantic_Type: Population Group
Preferred_Name: Red Cliff Chippewa
UMLS_CUI: C1555136
Legacy_Concept_Name: Red_Cliff_Chippewa
has exact synonym: Red Cliff Chippewa

Red Lake Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44925
Semantic_Type: Population Group
Preferred_Name: Red Lake Chippewa
UMLS_CUI: C1555137
Legacy_Concept_Name: Red_Lake_Chippewa
has exact synonym: Red Lake Chippewa

Saginaw Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44926
Semantic_Type: Population Group
Preferred_Name: Saginaw Chippewa
UMLS_CUI: C1555138
Legacy_Concept_Name: Saginaw_Chippewa
has exact synonym: Saginaw Chippewa

Sokoagon Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44929
Semantic_Type: Population Group
Preferred_Name: Sokoagon Chippewa
UMLS_CUI: C1555141
Legacy_Concept_Name: Sokoagon_Chippewa
has exact synonym: Sokoagon Chippewa

Turtle Mountain
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44930
Semantic_Type: Population Group
Preferred_Name: Turtle Mountain
UMLS_CUI: C1555142
Legacy_Concept_Name: Turtle_Mountain
has exact synonym: Turtle Mountain

White Earth
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C44931
Semantic_Type: Population Group
Preferred_Name: White Earth
UMLS_CUI: C1555143
Legacy_Concept_Name: White_Earth
has exact synonym: White Earth

Clatsop
type: Class
subclass of: Chinook
imported from: ncit.owl
code: C44932
Semantic_Type: Population Group
Preferred_Name: Clatsop
UMLS_CUI: C1555112
Legacy_Concept_Name: Clatsop
has exact synonym: Clatsop

Kathlamet
type: Class
subclass of: Chinook
imported from: ncit.owl
code: C44934
Semantic_Type: Population Group
Preferred_Name: Kathlamet
UMLS_CUI: C1555114
Legacy_Concept_Name: Kathlamet
has exact synonym: Kathlamet

Upper Chinook
type: Class
subclass of: Chinook
imported from: ncit.owl
code: C44935
Semantic_Type: Population Group
Preferred_Name: Upper Chinook
UMLS_CUI: C1555115
Legacy_Concept_Name: Upper_Chinook
has exact synonym: Upper Chinook

Wakiakum Chinook
type: Class
subclass of: Chinook
imported from: ncit.owl
code: C44936
Semantic_Type: Population Group
Preferred_Name: Wakiakum Chinook
UMLS_CUI: C1555116
Legacy_Concept_Name: Wakiakum_Chinook
has exact synonym: Wakiakum Chinook

Willapa Chinook
type: Class
subclass of: Chinook
imported from: ncit.owl
code: C44937
Semantic_Type: Population Group
Preferred_Name: Willapa Chinook
UMLS_CUI: C1555117
Legacy_Concept_Name: Willapa_Chinook
has exact synonym: Willapa Chinook

Wishram
type: Class
subclass of: Chinook
imported from: ncit.owl
code: C44938
Semantic_Type: Population Group
Preferred_Name: Wishram
UMLS_CUI: C1555118
Legacy_Concept_Name: Wishram
has exact synonym: Wishram

Cherokee Alabama
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44939
Semantic_Type: Population Group
Preferred_Name: Cherokee Alabama
UMLS_CUI: C1555094
Legacy_Concept_Name: Cherokee_Alabama
has exact synonym: Cherokee Alabama

Cherokees of Northeast Alabama
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44940
Semantic_Type: Population Group
Preferred_Name: Cherokees of Northeast Alabama
UMLS_CUI: C1555095
Legacy_Concept_Name: Cherokees_of_Northeast_Alabama
has exact synonym: Cherokees of Northeast Alabama

Cherokees of Southeast Alabama
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44941
Semantic_Type: Population Group
Preferred_Name: Cherokees of Southeast Alabama
UMLS_CUI: C1555096
Legacy_Concept_Name: Cherokees_of_Southeast_Alabama
has exact synonym: Cherokees of Southeast Alabama

Eastern Cherokee
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44942
Semantic_Type: Population Group
Preferred_Name: Eastern Cherokee
UMLS_CUI: C1555097
Legacy_Concept_Name: Eastern_Cherokee
has exact synonym: Eastern Cherokee

Echota Cherokee
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44943
Semantic_Type: Population Group
Preferred_Name: Echota Cherokee
UMLS_CUI: C1555098
Legacy_Concept_Name: Echota_Cherokee
has exact synonym: Echota Cherokee

Etowah Cherokee
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44944
Semantic_Type: Population Group
Preferred_Name: Etowah Cherokee
UMLS_CUI: C1555099
Legacy_Concept_Name: Etowah_Cherokee
has exact synonym: Etowah Cherokee

Tuscola
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44946
Semantic_Type: Population Group
Preferred_Name: Tuscola
UMLS_CUI: C1555101
Legacy_Concept_Name: Tuscola
has exact synonym: Tuscola

United Keetowah Band of Cherokee
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44947
Semantic_Type: Population Group
Preferred_Name: United Keetowah Band of Cherokee
UMLS_CUI: C1555102
Legacy_Concept_Name: United_Keetowah_Band_of_Cherokee
has exact synonym: United Keetowah Band of Cherokee

Western Cherokee
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C44948
Semantic_Type: Population Group
Preferred_Name: Western Cherokee
UMLS_CUI: C1555103
Legacy_Concept_Name: Western_Cherokee
has exact synonym: Western Cherokee

Canadian Indian
type: Class
subclass of: Canadian and Latin American Indian
imported from: ncit.owl
code: C44949
Semantic_Type: Population Group
Preferred_Name: Canadian Indian
UMLS_CUI: C1555084
Legacy_Concept_Name: Canadian_Indian
has exact synonym: Canadian Indian

Central American Indian
type: Class
subclass of: Canadian and Latin American Indian
imported from: ncit.owl
code: C44950
Semantic_Type: Population Group
Preferred_Name: Central American Indian
UMLS_CUI: C0021207
ALT_DEFINITION: The native people of Central America.
Legacy_Concept_Name: Central_American_Indian
has exact synonym: CENTRAL AMERICAN INDIAN
has exact synonym: Central American Indian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

French American Indian
type: Class
subclass of: Canadian and Latin American Indian
imported from: ncit.owl
code: C44951
Semantic_Type: Population Group
Preferred_Name: French American Indian
UMLS_CUI: C1555085
Legacy_Concept_Name: French_American_Indian
has exact synonym: French American Indian

Mexican American Indian
type: Class
subclass of: Canadian and Latin American Indian
imported from: ncit.owl
code: C44952
Semantic_Type: Population Group
Preferred_Name: Mexican American Indian
UMLS_CUI: C1555086
Legacy_Concept_Name: Mexican_American_Indian
has exact synonym: Mexican American Indian

South American Indian
type: Class
subclass of: Canadian and Latin American Indian
imported from: ncit.owl
code: C44953
Semantic_Type: Population Group
Preferred_Name: South American Indian
UMLS_CUI: C1610165
ALT_DEFINITION: The native people of South America.
Legacy_Concept_Name: South_American_Indian
has exact synonym: SOUTH AMERICAN INDIAN
has exact synonym: South American Indian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Spanish American Indian
type: Class
subclass of: Canadian and Latin American Indian
imported from: ncit.owl
code: C44954
Semantic_Type: Population Group
Preferred_Name: Spanish American Indian
UMLS_CUI: C1555087
Legacy_Concept_Name: Spanish_American_Indian
has exact synonym: Spanish American Indian

Aleut
type: Class
subclass of: Alaska Native
imported from: ncit.owl
code: C45170
Semantic_Type: Population Group
Preferred_Name: Aleut
UMLS_CUI: C0085766
Legacy_Concept_Name: Aleut
has exact synonym: Aleut

Columbia River Chinook
type: Class
subclass of: Chinook
imported from: ncit.owl
code: C45218
Semantic_Type: Population Group
Preferred_Name: Columbia River Chinook
UMLS_CUI: C1555113
Legacy_Concept_Name: Columbia_River_Chinook
has exact synonym: Columbia River Chinook

Northern Cherokee
type: Class
subclass of: Cherokee
imported from: ncit.owl
code: C45220
Semantic_Type: Population Group
Preferred_Name: Northern Cherokee
UMLS_CUI: C1555100
Legacy_Concept_Name: Northern_Cherokee
has exact synonym: Northern Cherokee

Platinum Eskimo
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C45221
Semantic_Type: Population Group
Preferred_Name: Platinum Eskimo
UMLS_CUI: C1553253
Legacy_Concept_Name: Platinum_Eskimo
has exact synonym: Platinum
has exact synonym: Platinum Eskimo

Deleware Indian
type: Class
subclass of: American Indian
imported from: ncit.owl
code: C45222
Semantic_Type: Population Group
Preferred_Name: Deleware Indian
UMLS_CUI: C1707669
Legacy_Concept_Name: Deleware_Indian
has exact synonym: Deleware
has exact synonym: Deleware Indian

Sault Ste. Marie Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C45223
Semantic_Type: Population Group
Preferred_Name: Sault Ste. Marie Chippewa
UMLS_CUI: C1555140
Legacy_Concept_Name: Sault_Ste_Marie_Chippewa
has exact synonym: Sault Ste. Marie Chippewa

St. Croix Chippewa
type: Class
subclass of: Chippewa
imported from: ncit.owl
code: C45224
Semantic_Type: Population Group
Preferred_Name: St. Croix Chippewa
UMLS_CUI: C1555139
Legacy_Concept_Name: St_Croix_Chippewa
has exact synonym: St. Croix Chippewa

St. George
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C45225
Semantic_Type: Population Group
Preferred_Name: St. George
UMLS_CUI: C1553316
Legacy_Concept_Name: St_George
has exact synonym: St. George

St. Paul
type: Class
subclass of: Unangan Aleut
imported from: ncit.owl
code: C45226
Semantic_Type: Population Group
Preferred_Name: St. Paul
UMLS_CUI: C1553317
Legacy_Concept_Name: St_Paul
has exact synonym: St. Paul

St. Mary's
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C45227
Semantic_Type: Population Group
Preferred_Name: St. Mary's
UMLS_CUI: C1553269
Legacy_Concept_Name: St_Marys
has exact synonym: St. Mary's

St. Michael
type: Class
subclass of: Yupik Eskimo
imported from: ncit.owl
code: C45228
Semantic_Type: Population Group
Preferred_Name: St. Michael
UMLS_CUI: C1553257
Legacy_Concept_Name: St_Michael
has exact synonym: St. Michael

Yavapai
type: Class
subclass of: Yuman
imported from: ncit.owl
code: C45229
Semantic_Type: Population Group
Preferred_Name: Yavapai
UMLS_CUI: C1551696
Legacy_Concept_Name: Yavapai
has exact synonym: Yavapai

Mean Arterial Pressure
type: Class
subclass of: Blood Pressure
definition: The mean pressure of the blood within the arterial circulation. The arterial pressure may be directly measured by insertion of an intra-arterial catheter connected to a transducer. The mean arterial pressure (MAP) can be calculated by subsequent analysis of the waveform. MAP can be approximated without an invasive procedure using the following formula: diastolic pressure plus 1/3 of the pulse pressure, where pulse pressure is systolic pressure - diastolic pressure.
imported from: ncit.owl
code: C49679
Semantic_Type: Quantitative Concept
Preferred_Name: Mean Arterial Pressure
UMLS_CUI: C0428886
Contributing_Source: CDISC
Contributing_Source: NCPDP
ALT_DEFINITION: The mean pressure of the blood within the arterial circulation. The arterial pressure may be directly measured by insertion of an intra-arterial catheter connected to a transducer. The mean arterial pressure (MAP) can be calculated by subsequent analysis of the waveform. MAP can be approximated without an invasive procedure using the following formula: diastolic pressure plus 1/3 of the pulse pressure, where pulse pressure is systolic pressure - diastolic pressure. (NCI)
Legacy_Concept_Name: Mean_Arterial_Pressure
has exact synonym: MAP
has exact synonym: Mean Arterial Pressure
in subset: NCIT C120532
in subset: NCIT C120533
in subset: NCIT C61410
in subset: NCIT C66741
in subset: NCIT C66830
in subset: NCIT C67153
in subset: NCIT C77526
in subset: NCIT C89415
in subset: NCIT C91101

Blood Pressure
type: Class
subclass of: Personal Attribute
definition: The pressure of the circulating blood against the walls of the blood vessels.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C25447
code: C54706
Semantic_Type: Clinical Attribute
Preferred_Name: Blood Pressure
UMLS_CUI: C0005823
Contributing_Source: NICHD
ALT_DEFINITION: The force of circulating blood on the walls of the arteries. Blood pressure is taken using two measurements: systolic (measured when the heart beats, when blood pressure is at its highest) and diastolic (measured between heart beats, when blood pressure is at its lowest). Blood pressure is written with the systolic blood pressure first, followed by the diastolic blood pressure (for example 120/80).
Legacy_Concept_Name: Blood_Pressure
NICHD_Hierarchy_Term: Blood Pressure
has exact synonym: BP
has exact synonym: Blood Pressure
has exact synonym: blood pressure
in subset: NCIT C89506
in subset: NCIT C90259

Never Smoker
type: Class
subclass of: Smoking Status
definition: A person who was not smoking at the time of the interview and has smoked less than 100 cigarettes in their life.
imported from: ncit.owl
code: C65108
Semantic_Type: Organism Attribute
Display_Name: Never Smoker
Preferred_Name: Never Smoker
UMLS_CUI: C0425293
Contributing_Source: CTRP
Legacy_Concept_Name: Never_Smoker
has exact synonym: Never Smoked
has exact synonym: Never Smoker
has exact synonym: Non-Smoker
in subset: NCIT C118168
in subset: NCIT C19752

Multiracial
type: Class
subclass of: Race
definition: Having ancestors of several or various races.
imported from: ncit.owl
code: C67109
Semantic_Type: Population Group
Preferred_Name: Multiracial
UMLS_CUI: C1881928
Legacy_Concept_Name: Multiracial
has exact synonym: Multiracial

Multiple Hispanic
type: Class
subclass of: Hispanic or Latino
definition: A person living in the United States of Mexican, Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans.
imported from: ncit.owl
code: C67111
Semantic_Type: Population Group
Preferred_Name: Multiple Hispanic
UMLS_CUI: C1881927
Legacy_Concept_Name: Multiple_Hispanic
has exact synonym: Multiple Hispanic

Puerto Rican
type: Class
subclass of: Hispanic or Latino
definition: A person of Puerto Rican culture or origin, regardless of race.
imported from: ncit.owl
code: C67112
Semantic_Type: Population Group
Preferred_Name: Puerto Rican
UMLS_CUI: C0034043
Contributing_Source: FDA
ALT_DEFINITION: A person of Puerto Rican descent.
Legacy_Concept_Name: Puerto_Rican
has exact synonym: PUERTO RICAN
has exact synonym: Puerto Rican
has exact synonym: Puertorican
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Mexican
type: Class
subclass of: Hispanic or Latino
definition: Denotes a person from or of Mexico.
imported from: ncit.owl
code: C67113
Semantic_Type: Population Group
Preferred_Name: Mexican
UMLS_CUI: C0240339
ALT_DEFINITION: A person of Mexican descent.
Legacy_Concept_Name: Mexican
has exact synonym: MEXICAN
has exact synonym: Mexican
in subset: NCIT C128690
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Mexican American
type: Class
subclass of: Hispanic or Latino
definition: Denotes an american citizen of Mexican descent.
imported from: ncit.owl
code: C67114
Semantic_Type: Population Group
Preferred_Name: Mexican American
UMLS_CUI: C0025884
ALT_DEFINITION: A person of Mexican and American descent.
Legacy_Concept_Name: Mexican_American
has exact synonym: MEXICAN AMERICAN
has exact synonym: Mexican American
in subset: NCIT C128690
in subset: NCIT C19752
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Cuban or Cuban American
type: Class
subclass of: Hispanic or Latino
definition: Denotes a person from or of Cuba or an American citizen of Cuban descent.
imported from: ncit.owl
code: C67115
Semantic_Type: Population Group
Preferred_Name: Cuban or Cuban American
UMLS_CUI: C0010436
ALT_DEFINITION: A person of Cuban and American descent.
Legacy_Concept_Name: Cuban_or_Cuban_American
has exact synonym: CUBAN AMERICAN
has exact synonym: Cuban or Cuban American
in subset: NCIT C128690
in subset: NCIT C19752
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Dominican
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of the Dominican Republic, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C67117
Semantic_Type: Population Group
Preferred_Name: Dominican
NCI_META_CUI: CL388698
ALT_DEFINITION: A person having origins in any of the original peoples of the Dominican Republic.
Legacy_Concept_Name: Dominican_Republican
has exact synonym: DOMINICAN
has exact synonym: Dominican
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Central American
type: Class
subclass of: Hispanic or Latino
definition: Denotes a person from the area between north and south America including persons from Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama, and the Panama Canal zone.
imported from: ncit.owl
code: C67118
Semantic_Type: Population Group
Preferred_Name: Central American
UMLS_CUI: C0238914
ALT_DEFINITION: A person of Central American descent.
Legacy_Concept_Name: Cental_American
has exact synonym: CENTRAL AMERICAN
has exact synonym: Central American
in subset: NCIT C128690
in subset: NCIT C19752
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Spanish
type: Class
subclass of: Hispanic or Latino
definition: Denotes a person from Spain or of Spanish descent.
imported from: ncit.owl
code: C67120
Semantic_Type: Population Group
Preferred_Name: Spanish
UMLS_CUI: C3161473
ALT_DEFINITION: A person from Spain or of Spanish descent.
Legacy_Concept_Name: Spanish
has exact synonym: SPANISH
has exact synonym: Spanish
in subset: NCIT C128690
in subset: NCIT C19752
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Current Every Day Smoker
type: Class
subclass of: Current Smoker
definition: Indicates a person who has smoked at least 100 cigarettes in his or her lifetime and who currently smokes every day.
imported from: ncit.owl
code: C67145
Semantic_Type: Organism Attribute
Preferred_Name: Current Every Day Smoker
UMLS_CUI: C3266136
Legacy_Concept_Name: Current_Every_Day_Smoker
has exact synonym: Current Every Day Smoker
has exact synonym: Daily Smoker
has exact synonym: Every Day Smoker
in subset: NCIT C19752

Current Some Day Smoker
type: Class
subclass of: Current Smoker
definition: Indicates a person who has smoked at least 100 cigarettes in his or her lifetime, who smokes now, but does not smoke every day.
imported from: ncit.owl
code: C67146
Semantic_Type: Organism Attribute
Preferred_Name: Current Some Day Smoker
UMLS_CUI: C1880200
Legacy_Concept_Name: Current_Some_Day_Smoker
has exact synonym: Chipper
has exact synonym: Current Some Day Smoker
has exact synonym: Non-Daily Smoker
has exact synonym: Occasional Smoker
has exact synonym: Some Day Smoker
in subset: NCIT C19752

Current Smoker
type: Class
subclass of: Smoking Status
definition: An adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes. Includes daily smokers and non-daily smokers (also known as occasional smokers).
imported from: ncit.owl
code: C67147
Semantic_Type: Organism Attribute
Display_Name: Current Smoker
Preferred_Name: Current Smoker
UMLS_CUI: C3241966
Contributing_Source: CTRP
Legacy_Concept_Name: Current_Smoker
has exact synonym: Current Smoker
has exact synonym: Smoker
in subset: NCIT C116977

Former Smoker
type: Class
subclass of: Smoking Status
definition: A person who was not smoking at the time of the interview but has smoked at least 100 cigarettes in their life.
imported from: ncit.owl
code: C67148
Semantic_Type: Organism Attribute
Display_Name: Former Smoker
Preferred_Name: Former Smoker
UMLS_CUI: C0337671
Contributing_Source: CTRP
Legacy_Concept_Name: Former_Smoker
has exact synonym: Former Smoker
has exact synonym: Prior Smoker
in subset: NCIT C116977
in subset: NCIT C118168
in subset: NCIT C19752

Smoker, Current Status Unknown
type: Class
subclass of: Smoking Status
definition: Indicates a person who is known to have smoked but whose current smoking status is unknown.
imported from: ncit.owl
code: C67150
Semantic_Type: Organism Attribute
Preferred_Name: Smoker, Current Status Unknown
UMLS_CUI: C1883049
Legacy_Concept_Name: Smoker_Current_Status_Unknown
has exact synonym: Smoker, Current Status Unknown
in subset: NCIT C19752

Unknown If Ever Smoked
type: Class
subclass of: Smoking Status
definition: Indicates that a person's smoking status is unknown.
imported from: ncit.owl
code: C67151
Semantic_Type: Organism Attribute
Preferred_Name: Unknown If Ever Smoked
UMLS_CUI: C1883465
Legacy_Concept_Name: Unknown_If_Ever_Smoked
has exact synonym: Unknown If Ever Smoked
in subset: NCIT C19752

Bahamian
type: Class
subclass of: African Caribbean
definition: Denotes the inhabitants of the Bahamas, a person from there, or their descendants elsewhere.
imported from: ncit.owl
code: C67271
Semantic_Type: Population Group
Preferred_Name: Bahamian
UMLS_CUI: C1553336
ALT_DEFINITION: A person having origins in any of the original peoples of the Bahamas.
Legacy_Concept_Name: Bahamian
has exact synonym: BAHAMIAN
has exact synonym: Bahamian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Smoker
type: Class
subclass of: Smoking Status
definition: A person who inhales or has inhaled combustible products of organic material during their lifetime.
imported from: ncit.owl
code: C68751
Semantic_Type: Organism Attribute
Preferred_Name: Smoker
UMLS_CUI: C0337664
Legacy_Concept_Name: Smoker
has exact synonym: Smoker

Age Started
type: Class
subclass of: Age
definition: The age of a person at the start of a specific event.
imported from: ncit.owl
code: C69217
Semantic_Type: Organism Attribute
Preferred_Name: Age Started
UMLS_CUI: C2348002
ALT_DEFINITION: The age of a patient on the first occurrence of an event, such as the first use of a medication.
Legacy_Concept_Name: Age_Started
has exact synonym: Age Started
in subset: NCIT C69186

Subject Age
type: Class
subclass of: Age
definition: The age of a person who is the subject in a study.
imported from: ncit.owl
code: C69260
Semantic_Type: Organism Attribute
Preferred_Name: Subject Age
UMLS_CUI: C2348575
ALT_DEFINITION: Age of patient who is the subject of observations.
Legacy_Concept_Name: Subject_Age
has exact synonym: Subject Age
in subset: NCIT C69186

Household Income
type: Class
subclass of: Income
definition: A demographic parameter indicating the amount of earnings made by a family.
imported from: ncit.owl
code: C70811
Semantic_Type: Quantitative Concept
Preferred_Name: Household Income
UMLS_CUI: C0557163
Legacy_Concept_Name: Household_Income
has exact synonym: Household Income

Birth Weight (NCIT)
type: Class
subclass of: Personal Attribute
definition: The first weight of a newborn obtained after birth.
imported from: ncit.owl
Has_NICHD_Parent: Body Weight
code: C76325
Semantic_Type: Quantitative Concept
Preferred_Name: Birth Weight
UMLS_CUI: C0005612
Contributing_Source: NICHD
ALT_DEFINITION: A measured weight of a newborn obtained immediately or shortly after birth.
Legacy_Concept_Name: Birth_Weight_New
NICHD_Hierarchy_Term: Birth Weight
has exact synonym: Birth Weight
in subset: NCIT C118466
in subset: NCIT C89506
in subset: NCIT C90259

South or Central American Indian
type: Class
subclass of: Race
definition: Denotes a person having origins in one of the indigenous people of South or Central America such as Mayans or Incas.
imported from: ncit.owl
code: C77809
Semantic_Type: Population Group
Preferred_Name: South or Central American Indian
UMLS_CUI: C2699496
Legacy_Concept_Name: South_or_Central_American_Indian
has exact synonym: South or Central American Indian

Caribbean Indian
type: Class
subclass of: Race
definition: Denotes a person having origins in one of the indigenous people of the Caribbean.
imported from: ncit.owl
code: C77810
Semantic_Type: Population Group
Preferred_Name: Caribbean Indian
UMLS_CUI: C2698999
ALT_DEFINITION: The native people of the Caribbean.
Legacy_Concept_Name: Caribbean_Indian
has exact synonym: CARIBBEAN INDIAN
has exact synonym: Caribbean Indian
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Mediterranean
type: Class
subclass of: Race
definition: Denotes a person having origins in any of the countries abutting the Mediterranean Sea, principally those of Europe.
imported from: ncit.owl
code: C77811
Semantic_Type: Population Group
Preferred_Name: Mediterranean
UMLS_CUI: C0240321
ALT_DEFINITION: A person having origins in any of the original peoples of the countries surrounding the Mediterranean sea.
Legacy_Concept_Name: Mediterranean
has exact synonym: MEDITERRANEAN
has exact synonym: Mediterranean
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

North American
type: Class
subclass of: Race
definition: Denotes a person of European, Middle Eastern, or North African ancestral origins whose family settled in a North American country such as the United States of America or Canada.
imported from: ncit.owl
code: C77812
Semantic_Type: Population Group
Preferred_Name: North American
UMLS_CUI: C0425358
Legacy_Concept_Name: North_American
has exact synonym: North American

North Coast of Africa
type: Class
subclass of: Race
definition: Denotes a person having origins in a northern country of Africa such as Egypt, Sudan, Libya, Algeria, Morocco, or Tunisia.
imported from: ncit.owl
code: C77813
Semantic_Type: Population Group
Preferred_Name: North Coast of Africa
UMLS_CUI: C2698500
ALT_DEFINITION: A person having origins in any of the original peoples of North Africa.
Legacy_Concept_Name: North_Coast_of_Africa_Origin
has exact synonym: NORTH AFRICAN
has exact synonym: North Coast of Africa
has exact synonym: North Coast of Africa Origin
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Northern European
type: Class
subclass of: Race
definition: Denotes a person having origins in any of the countries of northern Europe such as Belgium, Denmark, Austria, Switzerland, Norway, Sweden, or Great Britain.
imported from: ncit.owl
code: C77814
Semantic_Type: Population Group
Preferred_Name: Northern European
UMLS_CUI: C0239310
ALT_DEFINITION: A person having origins in any of the original peoples of Northern Europe.
Legacy_Concept_Name: Northern_European
has exact synonym: NORTHERN EUROPEAN
has exact synonym: Northern European
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Black South or Central American
type: Class
subclass of: Race
definition: Denotes a person having origins in any of the black racial groups of Africa whose family settled in a South or Central American country such as Argentina, Brazil, or Mexico.
imported from: ncit.owl
code: C77815
Semantic_Type: Population Group
Preferred_Name: Black South or Central American
UMLS_CUI: C2698522
Legacy_Concept_Name: Black_South_or_Central_American
has exact synonym: Black South or Central American

White Caribbean
type: Class
subclass of: Race
definition: Denotes a person with European, Middle Eastern, or North African ancestral origin whose family settled in the Caribbean region.
imported from: ncit.owl
code: C77816
Semantic_Type: Population Group
Preferred_Name: White Caribbean
UMLS_CUI: C2700273
ALT_DEFINITION: A person having origins in the original peoples of Europe, the Middle East, or North Africa, and the Caribbean.
Legacy_Concept_Name: White_Caribbean
has exact synonym: WHITE CARIBBEAN
has exact synonym: White Caribbean
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Western European
type: Class
subclass of: Race
definition: Denotes a person having origins in any of the countries of Western Europe such as Spain, Portugal, or France.
imported from: ncit.owl
code: C77817
Semantic_Type: Population Group
Preferred_Name: Western European
UMLS_CUI: C0239312
ALT_DEFINITION: A person having origins in any of the original peoples of Western Europe.
Legacy_Concept_Name: Western_European
has exact synonym: WESTERN EUROPEAN
has exact synonym: Western European
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

White South or Central American
type: Class
subclass of: Race
definition: Denotes a person of European ancestral origins whose family settled in a South or Central American country such as Argentina, Brazil, or Mexico.
imported from: ncit.owl
code: C77818
Semantic_Type: Population Group
Preferred_Name: White South or Central American
UMLS_CUI: C2700274
Legacy_Concept_Name: White_South_or_Central_American
has exact synonym: White South or Central American

Eastern European
type: Class
subclass of: Race
definition: Denotes a person having origins in any of the countries of Eastern Europe such as Czechoslovakia, Poland, Croatia, Hungary, Slovenia, Former Soviet Union, or Finland. It also includes persons who call themselves Gypsies from this region.
imported from: ncit.owl
code: C77819
Semantic_Type: Population Group
Preferred_Name: Eastern European
UMLS_CUI: C0239309
ALT_DEFINITION: A person having origins in any of the original peoples of Eastern Europe.
Legacy_Concept_Name: Eastern_European
has exact synonym: EASTERN EUROPEAN
has exact synonym: Eastern European
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Middle Eastern
type: Class
subclass of: Race
definition: Denotes a person having origins in the region of southwest Asia, between the India subcontinent and Europe, including Kuwait, Turkey, Lebanon, Israel, Iraq, Iran, Jordan, Saudi Arabia, lands east of Pakistan or the other countries of the Arabian Peninsula. Also includes people of Jewish ethnicity including Sephardic and Ashkenazic.
imported from: ncit.owl
code: C77820
Semantic_Type: Population Group
Preferred_Name: Middle Eastern
UMLS_CUI: C2698217
ALT_DEFINITION: A person having origins in any of the original peoples of the Middle East.
Legacy_Concept_Name: Middle_Eastern
has exact synonym: MIDDLE EASTERN
has exact synonym: Middle Eastern
in subset: NCIT C128689
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77527

Body Weight
type: Class
subclass of: Personal Attribute
definition: The weight of a subject.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C25447
code: C81328
Semantic_Type: Conceptual Entity
Preferred_Name: Body Weight
UMLS_CUI: C0005910
Contributing_Source: CDISC
Contributing_Source: NCPDP
Contributing_Source: NICHD
ALT_DEFINITION: The weight of a subject. (NCI)
Legacy_Concept_Name: Weight_of_Body
NICHD_Hierarchy_Term: Body Weight
has exact synonym: BW
has exact synonym: Body Weight
in subset: NCIT C61410
in subset: NCIT C77526
in subset: NCIT C89415
in subset: NCIT C89506
in subset: NCIT C89961
in subset: NCIT C89962
in subset: NCIT C90259
in subset: NCIT C91101

Gross Income
type: Class
subclass of: Income
definition: A person's total income before taxes, exclusions, and deductions.
imported from: ncit.owl
code: C85406
Semantic_Type: Group Attribute
Preferred_Name: Gross Income
UMLS_CUI: C2827632
has exact synonym: Gross Income

Inuit
type: Class
subclass of: Eskimo
definition: A general term for a group of culturally similar indigenous peoples inhabiting the Arctic regions of Canada, Greenland, Russia and the United States. In Alaska, the term Eskimo is commonly used, because it includes both Yupik and Inupiat, while Inuit is not accepted as a collective term. In Canada and Greenland, the term Eskimo has fallen out of favor, as it is considered pejorative by the natives and has been replaced by the term Inuit.
imported from: ncit.owl
code: C86558
Semantic_Type: Population Group
Preferred_Name: Inuit
UMLS_CUI: C0086484
has exact synonym: Inuit

Newborn Blood Pressure
type: Class
subclass of: Blood Pressure
definition: The systolic and diastolic blood pressure of the newborn upon examination; the normal range of the systolic blood pressure is 60 - 90, while the normal range of the diastolic blood pressure is 20-60.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C118807
code: C87105
Semantic_Type: Clinical Attribute
Preferred_Name: Newborn Blood Pressure
UMLS_CUI: C2828171
Contributing_Source: NICHD
NICHD_Hierarchy_Term: Newborn Blood Pressure
has exact synonym: Newborn Blood Pressure
in subset: NCIT C89506
in subset: NCIT C90259

Terminal Body Weight
type: Class
subclass of: Body Weight
definition: The weight of a subject at a specified end point.
imported from: ncit.owl
code: C90464
Semantic_Type: Quantitative Concept
Preferred_Name: Terminal Body Weight
UMLS_CUI: C2983672
Contributing_Source: CDISC
ALT_DEFINITION: The weight of a subject at a specified end point. (NCI)
has exact synonym: TERMBW
has exact synonym: Terminal Body Weight
in subset: NCIT C61410
in subset: NCIT C77526
in subset: NCIT C89961
in subset: NCIT C89962

Stature
type: Class
subclass of: Height
definition: The height of a person while standing.
imported from: ncit.owl
code: C94488
Semantic_Type: Conceptual Entity
Preferred_Name: Stature
UMLS_CUI: C0424639
ALT_DEFINITION: The height of a person while standing.
has exact synonym: Stature
has exact synonym: stature
label: standing height

adverse event
type: Class
subclass of: pathological bodily process
subclass of: Restriction
  on property: preceded_by
  some values from: medical intervention
definition: a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.
editor note: Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.
editor note: YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.
editor note: YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.
editor note: YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623.
editor note: YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740.
editor note: YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.
editor note: YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'.
definition editor: Yongqun He
alternative term: AE
alternative term: adverse reaction
definition source: WEB: http://en.wikipedia.org/wiki/Adverse_event
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068
imported from: oae.owl
comment: The OAE official website is: http://www.oae-ontology.org/.

medical intervention
type: Class
subclass of: planned process
definition: medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury.
editor note: The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States," Reference: http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis.
definition editor: YH
definition source: WEB: http://wiki.answers.com/Q/What_is_medical_intervention
imported from: oae.owl
imported from: omrse.owl

drug administration
type: Class
subclass of: medical intervention
definition: a medical intervention where a patient is administered with a drug
definition editor: YH
imported from: oae.owl

musculoskeletal or connective tissue AE
type: Class
subclass of: adverse event
definition: an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue.
definition editor: YH, RR, JX
alternative term: musculoskeletal and connective tissue disorder AE
definition source: WEB: http://www.cdc.gov/niosh/programs/msd/
imported from: oae.owl
has_MedDRA_id: 10028395
comment: A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture
see also: CTCAE: E13872

procedural complication AE
type: Class
subclass of: injury or procedural complication AE
definition: an adverse event that shows a complication that occurs after a medical procedure and is directly related to the precedure itself.
definition editor: SS, YH
alternative term: post-procedural AE
alternative term: procedural disorder AE
alternative term: procedure AE
imported from: oae.owl

surgery AE
type: Class
equivalent class: Restriction
  on property: adverse event preceded by
  some values from: surgery
subclass of: procedural complication AE
subclass of: Restriction
  on property: preceded by
  some values from: surgery
definition: a procedure complication AE that occurs after a surgery.
definition editor: YH
alternative term: surgery adverse event
alternative term: surgical procedure AE
imported from: oae.owl
comment: The key difference between a surgery and a procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. Technically speaking, a surgery is a specific type of procedure. A procedure is a broad general term that refers to any series of pre-defined steps that should be followed to achieve a desired result. Therefore, a “surgical procedure” is synonymous with a “surgery.” See more: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm.

surgery
type: Class
subclass of: medical procedure
definition: Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery.
definition editor: YH, SS
alternative term: surgical procedure
definition source: WEB: http://en.wikipedia.org/wiki/Surgery
definition source: WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm
imported from: oae.owl
imported from: omrse.owl
has_MedDRA_id: 10042609

fistula AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body.
definition source: WEB: http://medical-dictionary.thefreedictionary.com/fistula
imported from: oae.owl
has_MedDRA_id: 10067143
creator: YH, SS
see also: HPO: HP_0010294
see also: SIDER: C0016169

allergic brochospasm AE that requires treatment in emergency
type: Class
subclass of: serious adverse event
definition: a serious AE that is due to an allergic brochospasm, which causes a serious problem with breathing and requires treatment in an emergency room.
definition editor: YH, JX
definition source: URL: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: URL: https://en.wikipedia.org/wiki/Bronchospasm
imported from: oae.owl

pain AE
type: Class
subclass of: sensory capability AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a sensory capability AE that has an outcome of pain in a patient
definition editor: YH, MW
imported from: oae.owl
has_MedDRA_id: 10033371
see also: CTCAE: E11167
see also: HPO: HP_0010833
see also: NCIt: C3303
see also: SIDER: C0030193

sudden infant death AE
type: Class
subclass of: sudden death AE
subclass of: Restriction
  on property: occurs in
  some values from: infant stage
definition: a sudden death AE that occurs to an infant.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
imported from: oae.owl

cardiovascular AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: occurs in
    some values from: cardiovascular system
subclass of: adverse event
definition: an AE that occurs in cardiovascular system.
definition editor: YH
alternative term: cardiovascular disorder AE
imported from: oae.owl
has_MedDRA_id: 10007649
see also: HPO: HP_0001626
see also: SIDER: C0007222

behavioral and neurological AE
type: Class
equivalent class: Class
  intersection of: adverse event
  intersection of: Restriction
    on property: has participant quality
    some values from: behavior abnormal quality
subclass of: adverse event
definition: an adverse event that has an outcome of an abnormal behavior and neurological phenotype.
definition editor: YH, JX
alternative term: behavior AE
alternative term: behavioral AE
alternative term: behavioral disorder AE
alternative term: disruptive behavioral disorder AE
definition source: WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/
imported from: oae.owl
comment: any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls
see also: MP: MP_0004924

sensory capability AE
type: Class
subclass of: behavioral and neurological AE
imported from: oae.owl
comment: a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus
see also: MP: MP_0002067

hematuria AE
type: Class
subclass of: urinary system AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a urinary system AE that results in the presence of blood in the urine
definition editor: YH, SJ, MW
alternative term: UMLS CUI: C0018965 (hematuria AND haematuria); UMLS CUI: C0947999 (blood urine presence)
alternative term: blood urine
alternative term: blood urine presence
alternative term: haematuria AE
definition source: WEB: http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/
imported from: oae.owl
has_MedDRA_id: 10018867
has_MedDRA_id: 10018870
has_MedDRA_id: 10019450
has exact synonym: hematuria
comment: Hematuria AE can be caused by menstruation, vigorous exercise, sexual activity, viral illness, trauma, or infection, such as a urinary tract infection (UTI), along with more serious disorders such as cancer, disease, and clotting.
see also: CTCAE: E13000
see also: MP: MP_0005161
see also: NCIt: C3090

urinary system AE
type: Class
equivalent class: Restriction
  on property: AE occurs in
  some values from: renal system
subclass of: adverse event
definition: an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine
definition editor: YH
imported from: oae.owl
see also: MP: MP_0005502

serious adverse event
type: Class
subclass of: adverse event
definition: serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death.
definition editor: YH, MC
alternative term: serious adverse event
alternative term: severe adverse event
definition source: WEB: http://en.wikipedia.org/wiki/Serious_adverse_event
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA
imported from: oae.owl

death AE
type: Class
subclass of: serious adverse event
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G5
definition: a serious adverse event that has an outcome of death.
definition editor: YH
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
imported from: oae.owl
has_MedDRA_id: 10011906
has_MedDRA_id: 10011914
has exact synonym: death
see also: CTCAE: E11080
see also: HPO: HP_0001645
see also: NCIt: C28554
see also: SIDER: C1306577

life-threating AE
type: Class
subclass of: serious adverse event
definition: a serious AE that is suspected to put the patient at substantial risk of dying at the time of the adverse event, or that the use or continued use of the device or other medical product might have resulted in the death of the patient.
definition editor: DJ, SS, YH, JX
alternative term: apparent life threatening event AE
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
imported from: oae.owl
has_MedDRA_id: 10065044

hospitalization AE
type: Class
subclass of: serious adverse event
definition: a serious adverse event that leads to hospitalization. Such an adverse event resulted in an admission to the hospital or prolongation of hospitalization.
definition editor: YH, JX
alternative term: adverse event leading to hospitalization
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
imported from: oae.owl

disability or permanent damage AE
type: Class
subclass of: serious adverse event
definition: a serious adverse event that leads to disability or permanent damage. Such an adverse event results in a substantial disruption of a person's ability to conduct normal life functions, i.e., the adverse event resulted in a significant, persistent or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities and/or quality of life.
definition editor: YH, JX
alternative term: adverse event leading to disability
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
imported from: oae.owl

congenital anomaly or birth defect AE
type: Class
subclass of: serious adverse event
definition: a serious adverse event that resulted in congenital anomaly and bith defect, leading to suspicions that an exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child.
definition editor: YH, JX
alternative term: adverse event leading to congenital anomaly
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.thefreedictionary.com/birth+defect
imported from: oae.owl
has_MedDRA_id: 10010356

adverse event that requires intervention to prevent permanent impairment or damage
type: Class
subclass of: serious adverse event
definition: a serious adverse event which is an adverse event that requires intervention to prevent permanent impairment or damage leads to suspicions that the use of a medical product may result in a condition which requires a medical or surgical intervention to preclude permanent impairment or damage to a patient.
definition editor: YH, JX
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
imported from: oae.owl

hematoma AE
type: Class
subclass of: cardiovascular AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise.
editor note: YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma".
definition editor: SS, YH
alternative term: bruise AE
alternative term: bruising AE
alternative term: ecchymoses AE
alternative term: haematoma AE
definition source: WEB: http://en.wikipedia.org/wiki/Hematoma
imported from: oae.owl
has_MedDRA_id: 10006504
has_MedDRA_id: 10018852
has_MedDRA_id: 10019428
see also: CTCAE: E13775 (hematoma); CTCAE: E11666 (brruising)
see also: HPO: HP_0001892
see also: NCIt: C37921 (Bruising); NCIt: C50579 (Hematoma)
see also: SIDER: C0018944

connective tissue disorder AE
type: Class
subclass of: musculoskeletal or connective tissue AE
definition: an adverse event that has an outcome of disease in the biological tissue that supports, binds together and protects organs
definition editor: DJ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/connective+tissue+disease
imported from: oae.owl
has_MedDRA_id: 10061087
see also: HPO: HP_0003549
see also: SIDER: C0009782

soft tissue infection AE
type: Class
subclass of: connective tissue disorder AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G2
    union of: AE severity G3
    union of: AE severity G4
    union of: AE severity G5
definition: a connective tissue disorder AE that occurs in the non-skeletal tissue, usually subcutaneous and muscle tissue
definition editor: SZ, SS, YH
definition source: WEB: http://www.reference.md/files/D018/mD018461.html
imported from: oae.owl
has_MedDRA_id: 10062255
has exact synonym: soft tissue infection
see also: CTCAE: E11579
see also: HPO: HP_0002719
see also: NCIt: C79745
see also: SIDER: C0149778

sudden death AE
type: Class
subclass of: death AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G5
definition: a death AE that has an outcome of unexpected death, 1 to 24 hours after the onset of symptoms
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/sudden+death
imported from: oae.owl
has_MedDRA_id: 10042434
has_MedDRA_id: 10042435
see also: CTCAE: E11171
see also: HPO: HP_0001645
see also: NCIt: C50911
see also: SIDER: C0011071

severity of adverse event
type: Class
subclass of: process quality
definition: a process quality that represents the level of severity of an adverse event.
definition editor: YH, SS
alternative term: AE severity
imported from: oae.owl

AE severity G0
type: Class
subclass of: severity of adverse event
definition: a severity of AE that shows sign and symptom within normal limits.
definition editor: YH, SS
alternative term: AE severity Grade 0
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_0_Adverse_Event
imported from: oae.owl
comment: Note the AE severity Grade 0 equals to CTCAE G0 AE severity.
see also: CTCAE4: E10004 (Grade 0 Adverse Event)

AE severity G1
type: Class
subclass of: severity of adverse event
definition: a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated.
definition editor: YH, SS
alternative term: AE severity Grade 1
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event
imported from: oae.owl
comment: Note the AE severity Grade 1 equals to CTCAE G1 AE severity.
see also: CTCAE4: E10005 (Grade 1 Adverse Event)

AE severity G2
type: Class
subclass of: severity of adverse event
definition: a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).
definition editor: YH, SS
alternative term: AE severity Grade 2
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event
imported from: oae.owl
comment: Note the AE severity Grade 2 equals to CTCAE G2 AE severity.
see also: CTCAE4: E10006 (Grade 2 Adverse Event)

AE severity G3
type: Class
subclass of: severity of adverse event
definition: a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet).
definition editor: YH, SS
alternative term: AE severity Grade 3
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event
imported from: oae.owl
comment: Note the AE severity Grade 3 equals to CTCAE G3 AE severity.
see also: CTCAE4: E10007 (Grade 3 Adverse Event)

AE severity G4
type: Class
subclass of: severity of adverse event
definition: a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral).
definition editor: YH, SS
alternative term: AE severity Grade 4
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event
imported from: oae.owl
comment: Note the AE severity Grade 4 equals to CTCAE G4 AE severity.
see also: CTCAE4: E10008 (Grade 4 Adverse Event)

AE severity G5
type: Class
subclass of: severity of adverse event
definition: a severity of AE that results in death.
definition editor: YH, SS
alternative term: AE severity Grade 5
definition source: Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event
imported from: oae.owl
comment: Note the AE severity Grade 5 equals to CTCAE G5 AE severity.
see also: CTCAE4: E10009 (Grade 5 Adverse Event)

initial hospitalization AE
type: Class
subclass of: hospitalization AE
definition: a hospitalization AE that leads to an intial hospitalization.
definition editor: YH, JX
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
imported from: oae.owl

prolonged hospitalization AE
type: Class
subclass of: hospitalization AE
definition: a hospitalization AE that leads to a prolonged hospitalization.
definition editor: YH, JX
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
imported from: oae.owl

injury or procedural complication AE
type: Class
subclass of: adverse event
definition: an adverse event that shows a result of injury or procedural complication.
definition editor: JX, YH
alternative term: injury and procedural complication AE
imported from: oae.owl

flank pain AE
type: Class
subclass of: pain AE
subclass of: Restriction
  on property: has participant quality
  some values from: Class
    union of: AE severity G1
    union of: AE severity G2
    union of: AE severity G3
definition: a pain AE that has marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip.
definition editor: MW, YH
imported from: oae.owl
has_MedDRA_id: 10016750
has exact synonym: flank pain
see also: CTCAE: E12414
see also: NCIt: C34615

fetal death AE
type: Class
subclass of: death AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G5
definition: a death AE that has death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation.
definition editor: MW, YH
imported from: oae.owl
has_MedDRA_id: 10016479
see also: CTCAE: E12855
see also: NCIt: C50620

medical procedure
type: Class
subclass of: medical intervention
definition: a medical intervention that refers to any series of pre-defined steps that should be followed to achieve a desired result.
definition editor: YH, SS
definition source: WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm
imported from: oae.owl
imported from: omrse.owl

behavior abnormal quality
type: Class
subclass of: behavioral quality
definition editor: YH, JX
alternative term: a behavioral quality where the behavior in an organism is abnormal.
definition source: WEB: https://en.wikipedia.org/wiki/Abnormality_(behavior)
imported from: oae.owl

death neonatal AE
type: Class
subclass of: death AE
subclass of: Restriction
  on property: has participant quality
  some values from: AE severity G5
definition: a death AE that has cessation of life occurring during the first 28 days of life.
definition editor: MW, YH
imported from: oae.owl
has_MedDRA_id: 10011912
see also: CTCAE: E11078
see also: NCIt: C80082

subcapsular hematoma AE
type: Class
subclass of: hematoma AE
definition: An adverse event of hematoma in the subcapsular space of the kidney. This event occurs after a medical intervention, and may be caused by a tumor, trauma, vasculitis, renal infarction, or other disease process.
definition editor: YH, EO
definition source: https://medical-dictionary.thefreedictionary.com/subcapsular+hematoma
imported from: oae.owl
has exact synonym: subcapsular hematoma

perinephric hematoma AE
type: Class
subclass of: hematoma AE
definition: An adverse event of hematoma occurring around the kidney.
definition editor: YH, EO
imported from: oae.owl
has exact synonym: perinephric hematoma

arteriovenous fistula AE
type: Class
subclass of: fistula AE
definition editor: YH, EO
imported from: oae.owl
has_broad_synonym: arteriovenous fistulae
has exact synonym: arteriovenous fistula

puncturing of adjacent organ AE
type: Class
subclass of: surgery AE
definition: An adverse event of surgery that leads to the puncturing of an adjacent organ. For example, a needle to the kidney may puncture the adjacent organs.
definition editor: Jennifer Schaub, Oliver He
alternative term: puncturing of adjacent organs
definition source: https://www.ncbi.nlm.nih.gov/books/NBK493205/
imported from: oae.owl

first blood draw date
type: Class
subclass of: date of specimen collection
definition: A date of specimen collection for the first collection of blood from a donor.
definition editor: Person: Chris Stoeckert, Helena Ellis, Jie Zheng
definition source: OBIB
ontology term requester: NCI BBRB
imported from: obib.owl

first tissue removed date
type: Class
subclass of: date of specimen collection
definition: A date of specimen collection for the first collection of a tissue from a donor.
definition editor: Person: Chris Stoeckert, Helena Ellis, Jie Zheng
definition source: OBIB
ontology term requester: NCI BBRB
imported from: obib.owl

date of surgical removal of specimen
type: Class
subclass of: date of specimen collection
definition: A date of specimen collection on which the surgery was performed during which the specimen was collected.
definition editor: Person: Chris Stoeckert, Helena Ellis, Jie Zheng
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: obib.owl

date of specimen collection
type: Class
subclass of: data item
subclass of: Class
  intersection of: data item
  intersection of: Restriction
    on property: is about
    some values from: Class
      intersection of: one-dimensional temporal region
      intersection of: Restriction
        on property: has part
        some values from: Class
definition: A data item that indicates the time when the collection of a specimen occurred.
definition editor: Alice Nzinga
definition editor: Mathias Brochhausen
alternative term: date of specimen preparation
imported from: obib.owl
comment: It is denoted by Date in ISO-standard (8601) time format.

planned process
type: Class
equivalent class: Restriction
  on property: realizes
  some values from: Restriction
    on property: concretizes
    some values from: plan specification
subclass of: process
editor preferred label: planned process
example of usage: Injecting mice with a vaccine in order to test its efficacy
has curation status: ready for release
definition: A process that realizes a plan which is the concretization of a plan specification.
definition: A processual entity that realizes a plan which is the concretization of a plan specification.
editor note: 'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)
editor note: We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some objectives is a planned process.
definition editor: Bjoern Peters
definition source: branch derived
curator note: 6/11/9: Edited at workshop. Used to include: is initiated by an agent
curator note: This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call)
imported from: dron.owl
imported from: envo.owl
imported from: ico.owl
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: vo.owl

clinical research coordinator role
type: Class
subclass of: worker role
editor preferred label: clinical research coordinator role
has curation status: metadata incomplete
definition: a worker role comprised of handling the administrative duties of a trial or study.
definition editor: Person:Jennifer Fostel
alternative term: clinical research coordinator
imported from: Ontology for Biomedical Investigations

processed material
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: is_specified_output_of
    some values from: material processing
subclass of: material entity
editor preferred label: processed material
example of usage: Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples
has curation status: ready for release
definition: Is a material entity that is created or changed during material processing.
definition editor: PERSON: Alan Ruttenberg
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: vo.owl

investigation
type: Class
subclass of: planned process
subclass of: Restriction
  on property: has part
  some values from: documenting
subclass of: Restriction
  on property: has part
  some values from: drawing a conclusion based on data
subclass of: Restriction
  on property: has part
  some values from: study design execution
subclass of: Restriction
  on property: has part
  some values from: Class
    intersection of: planning
    intersection of: Restriction
      on property: has_specified_output
      some values from: study design
editor preferred label: investigation
example of usage: Lung cancer investigation using expression profiling, a stem cell transplant investigation, biobanking is not an investigation, though it may be part of an investigation
has curation status: ready for release
definition: a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s).
definition editor: Bjoern Peters
definition source: OBI branch derived
curator note: Could add specific objective specification
curator note: Following OBI call November 2012,26th: it was decided there was no need for adding "achieves objective of drawing conclusion" as existing relations were providing equivalent ability. this note closes the issue and validates the class definition to be part of the OBI core editor = PRS
imported from: Ontology for Biomedical Investigations
ISA alternative term: study

evaluant role
type: Class
subclass of: role
subclass of: Restriction
  on property: characteristic of
  some values from: material entity
subclass of: Restriction
  on property: realized in
  all values from: assay
editor preferred label: evaluant role
example of usage: When a specimen of blood is assayed for glucose concentration, the blood has the evaluant role. When measuring the mass of a mouse, the evaluant is the mouse. When measuring the time of DNA replication, the evaluant is the DNA. When measuring the intensity of light on a surface, the evaluant is the light source.
has curation status: ready for release
definition: a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role
editor note: Role call - 17nov-08: JF and MC think an evaluant role is always specified input of a process. Even in the case where we have an assay taking blood as evaluant and outputting blood, the blood is not the specified output at the end of the assay (the concentration of glucose in the blood is)
editor note: examples of features that could be described in an evaluant: quality.... e.g. "contains 10 pg/ml IL2", or "no glucose detected")
definition editor: GROUP: Role Branch
definition source: OBI
curator note: Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term.
imported from: Ontology for Biomedical Investigations

assay
type: Class
equivalent class: Restriction
  on property: achieves_planned_objective
  some values from: assay objective
subclass of: planned process
subclass of: Restriction
  on property: realizes
  some values from: evaluant role
subclass of: Restriction
  on property: has_specified_input
  some values from: Class
    intersection of: material entity
    intersection of: Restriction
      on property: has role
      some values from: evaluant role
subclass of: Restriction
  on property: has_specified_output
  some values from: Class
    intersection of: data item
    intersection of: Restriction
      on property: is about
      some values from: Class
        intersection of: material entity
        intersection of: Restriction
editor preferred label: assay
example of usage: Assay the wavelength of light emitted by excited Neon atoms. Count of geese flying over a house.
has curation status: ready for release
definition: A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies.
editor note: 12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation.
definition editor: PlanAndPlannedProcess Branch
alternative term: measuring
alternative term: scientific observation
definition source: OBI branch derived
imported from: Ontology for Biomedical Investigations
ISA alternative term: study assay
IEDB alternative term: any method

sample preparation for assay
type: Class
subclass of: material processing
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: material transformation objective
editor preferred label: sample preparation for assay
has curation status: pending final vetting
definition: A sample_preparation_for_assay is a protocol_application including material_enrollments and biomaterial_transformations. definition_source: OBI.
definition editor: PlanAndPlannedProcess Branch
alternative term: study
definition source: OBI branch derived
imported from: Ontology for Biomedical Investigations

diagnosis textual entity
type: Class
subclass of: textual entity
editor preferred label: diagnosis textual entity
has curation status: metadata incomplete
definition: diagnosis is an assessment of a disease or injury, its likely prognosis and treatment.
definition editor: Jennifer Fostel
imported from: Ontology for Biomedical Investigations

culture medium
type: Class
subclass of: processed material
editor preferred label: culture medium
example of usage: A growth medium or culture medium is a substance in which microorganisms or cells can grow. Wikipedia, growth medium, Feb 29, 2008
has curation status: ready for release
definition: a processed material that provides the needed nourishment for microorganisms or cells grown in vitro.
editor note: changed from a role to a processed material based on on Aug 22, 2011 dev call. Details see the tracker item: http://sourceforge.net/tracker/?func=detail&aid=3325270&group_id=177891&atid=886178 Modification made by JZ.
definition editor: Person: Jennifer Fostel, Jie Zheng
definition source: OBI
imported from: Ontology for Biomedical Investigations

reagent role
type: Class
subclass of: role
editor preferred label: reagent role
example of usage: Buffer, dye, a catalyst, a solvating agent.
has curation status: metadata complete
definition: A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer.
definition editor: PERSON:Matthew Brush
alternative term: reagent
definition source: PERSON:Matthew Brush
curator note: Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term. May 28 2013. Updated definition taken from ReO based on discussions initiated in Philly 2011 workshop. Former defnition described a narrower view of reagents in chemistry that restricts bearers of the role to be chemical entities ("a role played by a molecular entity used to produce a chemical reaction to detect, measure, or produce other substances"). Updated definition allows for broader view of reagents in the domain of biomedical research to include larger materials that have parts that participate chemically in a molecular reaction or interaction.
imported from: Ontology for Biomedical Investigations
comment: (copied from ReO) Reagents are distinguished from instruments or devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in or have parts that participate in some chemical interaction or reaction during their intended participation in some technique. By contrast, instruments do not participate in a chemical reaction/interaction during the technique. Reagents are distinguished from study subjects/evaluants in that study subjects and evaluants are that about which conclusions are drawn and knowledge is sought in an investigation - while reagents, by definition, are not. It should be noted, however, that reagent and study subject/evaluant roles can be borne by instances of the same type of material entity - but a given instance will realize only one of these roles in the execution of a given assay or technique. For example, taq polymerase can bear a reagent role or an evaluant role. In a DNA sequencing assay aimed at generating sequence data about some plasmid, the reagent role of the taq polymerase is realized. In an assay to evaluate the quality of the taq polymerase itself, the evaluant/study subject role of the taq is realized, but not the reagent role since the taq is the subject about which data is generated. In regard to the statement that reagents are 'distinct' from the specified outputs of a technique, note that a reagent may be incorporated into a material output of a technique, as long as the IDENTITY of this output is distinct from that of the bearer of the reagent role. For example, dNTPs input into a PCR are reagents that become part of the material output of this technique, but this output has a new identity (ie that of a 'nucleic acid molecule') that is distinct from the identity of the dNTPs that comprise it. Similarly, a biotin molecule input into a cell labeling technique are reagents that become part of the specified output, but the identity of the output is t…

material processing
type: Class
equivalent class: Restriction
  on property: achieves_planned_objective
  some values from: material transformation objective
subclass of: planned process
subclass of: Restriction
  on property: has_specified_output
  some values from: processed material
subclass of: Restriction
  on property: has_specified_input
  all values from: material entity
editor preferred label: material processing
example of usage: A cell lysis, production of a cloning vector, creating a buffer.
has curation status: ready for release
definition: A planned process which results in physical changes in a specified input material
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Frank Gibson
definition editor: PERSON: Jennifer Fostel
definition editor: PERSON: Melanie Courtot
definition editor: PERSON: Philippe Rocca Serra
alternative term: material transformation
definition source: OBI branch derived
imported from: Ontology for Biomedical Investigations

participant under investigation role
type: Class
subclass of: role
subclass of: Restriction
  on property: realized in
  all values from: study design execution
editor preferred label: study subject role
example of usage: Human subjects in a clinical trial, rats in a toxicogenomics study, tissue cutlures subjected to drug tests, fish observed in an ecotoxicology study. Parasite example: people are infected with a parasite which is then extracted; the particpant under investigation could be the parasite, the people, or a population of which the people are members, depending on the nature of the study. Lake example: a lake could realize this role in an investigation that assays pollution levels in samples of water taken from the lake.
has curation status: ready for release
definition: A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected.
editor note: A participant can realize both "specimen role" and "participant under investigation role" at the same time. However "participant under investigation role" is distinct from "specimen role", since a specimen could somehow be involved in an investigation without being the thing that is under investigation.
definition editor: GROUP: Role Branch
definition source: OBI
curator note: Following OBI call November 2012,26th: 1. it was decided there was no need for moving the children class and making them siblings of study subject role. 2. it also settles the disambiguation about 'study subject'. This is about the individual participating in the investigation/study, Not the 'topic' (as in 'toxicity study') of the investigation/study This note closes the issue and validates the class definition to be part of the OBI core editor = PRS
imported from: Ontology for Biomedical Investigations

responsible party role
type: Class
subclass of: investigation agent role
editor preferred label: responsible party role
example of usage: he THERAPIST has the ability to print a separate statement for the patient and each responsible party. http://www.beaverlog.com/therapist/ez_support/billing/responsible_party_statements.htm
has curation status: metadata complete
definition: a study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study
definition editor: Person: Jennifer Fostel
alternative term: responsible party
definition source: OBI
imported from: Ontology for Biomedical Investigations

specimen role
type: Class
subclass of: role
subclass of: material entity role
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    intersection of: material entity
    intersection of: Restriction
      on property: is_specified_output_of
      some values from: specimen collection process
editor preferred label: specimen role
example of usage: liver section; a portion of a culture of cells; a nemotode or other animal once no longer a subject (generally killed); portion of blood from a patient.
has curation status: ready for release
definition: a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation
editor note: 22Jun09. The definition includes whole organisms, and can include a human. The link between specimen role and study subject role has been removed. A specimen taken as part of a case study is not considered to be a population representative, while a specimen taken as representing a population, e.g. person taken from a cohort, blood specimen taken from an animal) would be considered a population representative and would also bear material sample role.
editor note: Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.
editor note: blood taken from animal: animal continues in study, whereas blood has role specimen. something taken from study subject, leaves the study and becomes the specimen.
editor note: parasite example - when parasite in people we study people, people are subjects and parasites are specimen - when parasite extracted, they become subject in the following study specimen can later be subject.
definition editor: GROUP: Role Branch
definition source: OBI
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

worker role
type: Class
subclass of: investigation agent role
editor preferred label: worker role
example of usage: Public sector workers in states that run their own OSHA programs are covered by those states. http://www.osha.gov/as/opa/worker/index.html
has curation status: metadata complete
definition: a personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline
editor note: "executes the study plan" includes the suppliers and manufacturers of reagents and other materials used in the study
definition editor: Person:Jennifer Fostel
alternative term: worker
definition source: OBI
imported from: Ontology for Biomedical Investigations

population
type: Class
subclass of: material entity
editor preferred label: population
example of usage: PMID12564891. Environ Sci Technol. 2003 Jan 15;37(2):223-8. Effects of historic PCB exposures on the reproductive success of the Hudson River striped bass population.
has curation status: pending final vetting
definition: a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area
editor note: 1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: http://code.google.com/p/popcomm-ontology/
definition editor: PERSON: Philippe Rocca-Serra
definition source: adapted from Oxford English Dictionnary
curator note: rem1: collection somehow always involve a selection process
imported from: Ontology for Biomedical Investigations

investigation agent role
type: Class
equivalent class: Class
  intersection of: role
  intersection of: Restriction
    on property: characteristic of
    some values from: Restriction
      on property: bearer of
      some values from: Restriction
        on property: concretizes
        some values from: Restriction
subclass of: role
subclass of: Restriction
  on property: realized in
  all values from: investigation
editor preferred label: investigation agent role
example of usage: The person perform microarray experiments and submit microarray results (including raw data, processed data) with experiment description to ArrayExpress.
has curation status: ready for release
definition: A role borne by an entity and that is realized in a process that is part of an investigation in which an objective is achieved. These processes include, among others: planning, overseeing, funding, reviewing.
editor note: Implementing a study means carrying out or performing the study and providing reagents or other materials used in the study and other tasks without which the study would not happen.
editor note: Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable representing investigations run by robot scientists such as ADAM (King et al, Science, 2009)
definition editor: GROUP: Role Branch
alternative term: investigator
definition source: OBI
curator note: Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term.
imported from: Ontology for Biomedical Investigations
ISA alternative term: study person role
comment: Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable investigations run by robot scientists such as ADAM (King et al, Science, 2009)

sponsor role
type: Class
subclass of: responsible party role
editor preferred label: sponsor role
has curation status: metadata complete
definition: a responsible party role involved with any of the following activities: initiating, managing and funding a study
definition editor: Person: Jennifer Fostel
alternative term: sponsor
curator note: CDISC definition: sponsor. 1. An individual, company, institution, or organization that takes responsibility for the initiation, management, and/or financing of a clinical trial. 2. A corporation or agency whose employees conduct the investigation is considered a sponsor; employees are considered investigators
imported from: Ontology for Biomedical Investigations

organization
type: Class
subclass of: material entity
editor preferred label: organization
example of usage: PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods.
has curation status: ready for release
definition: An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members.
definition: An organization is a continuant entity which can play roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members.
editor note: BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that. The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based: 1) there are organization_member_roles (president, treasurer, branch editor), with individual persons as bearers 2) there are organization_roles (employer, owner, vendor, patent holder) 3) an organization has a charter / rules / bylaws, which specify what roles there are, how they should be realized, and how to modify the charter/rules/bylaws themselves. It is debatable what the organization itself is (some kind of dependent continuant or an aggregate of people). This also determines who/what the bearer of organization_roles' are. My personal favorite is still to define organization as a kind of 'legal entity', but thinking it through leads to all kinds of questions that are clearly outside the scope of OBI. Interestingly enough, it does not seem to matter much where we place organization itself, as long as we can subclass it (University, Corporation, Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO, W3C, University of Oklahoma), and have it play roles. This leads to my proposal: We define organization through the statements 1 - 3 above, but without an 'is a' statement for now. We can leave it in its current place in the is_a hierarchy (material entity) or move it up to 'continuant'. We leave further clarifications to BFO, and close this issue for now.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Philippe Rocca-Serra
definition editor: PERSON: Susanna Sansone
definition source: GROUP: OBI
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

protocol
type: Class
subclass of: plan specification
editor preferred label: protocol
example of usage: PCR protocol, has objective specification, amplify DNA fragment of interest, and has action specification describes the amounts of experimental reagents used (e..g. buffers, dNTPS, enzyme), and the temperature and cycle time settings for running the PCR.
has curation status: ready for release
definition: A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process.
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29)
imported from: Ontology for Biomedical Investigations
ISA alternative term: study protocol

analyte role
type: Class
subclass of: measurand role
subclass of: Restriction
  on property: role of
  some values from: Class
    union of: molecular entity
    union of: atom
editor preferred label: analyte role
example of usage: Glucose in blood (measured in an assay to determine the concentration of glucose).
has curation status: ready for release
definition: A measurand role borne by a molecular entity or an atom and realized in an analyte assay which achieves the objective to measure the magnitude/concentration/amount of the analyte in the entity bearing evaluant role.
editor note: interestingly, an analyte is still an analyte even if it is not detected. for this reason it does not bear a specified input role
editor note: pH (technically the inverse log of [H+]) may be considered a quality; this remains to be tested.
editor note: qualities such as weight, color are not assayed but measured, so they do not fall into this category.
definition editor: GROUP: Role Branch
definition source: OBI
curator note: Feb 10, 2009. changes after discussion at OBI Consortium Workshop Feb 2-6, 2009. accepted as core term.
imported from: Ontology for Biomedical Investigations

drawing a conclusion based on data
type: Class
subclass of: planned process
subclass of: Restriction
  on property: has_specified_input
  some values from: data item
subclass of: Restriction
  on property: has_specified_output
  some values from: conclusion based on data
editor preferred label: interpreting data
example of usage: Concluding that a gene is upregulated in a tissue sample based on the band intensity in a western blot. Concluding that a patient has a infection based on measurement of an elevated body temperature and reported headache. Concluding that there were problems in an investigation because data from PCR and microarray are conflicting. Concluding that 'defects in gene XYZ cause cancer due to improper DNA repair' based on data from experiments in that study that gene XYZ is involved in DNA repair, and the conclusion of a previous study that cancer patients have an increased number of mutations in this gene.
has curation status: ready for release
definition: A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Jennifer Fostel
definition source: Bjoern Peters
imported from: Ontology for Biomedical Investigations

planning
type: Class
subclass of: process
subclass of: Class
  intersection of: process
  intersection of: Restriction
    on property: has_participant
    some values from: plan specification
editor preferred label: planning
example of usage: The process of a scientist thinking about and deciding what reagents to use as part of a protocol for an experiment. Note that the scientist could be human or a "robot scientist" executing software.
has curation status: ready for release
definition: a process of creating or modifying a plan specification
editor note: 7/18/2011 BP: planning used to itself be a planned process. Barry Smith pointed out that this would lead to an infinite regression, as there would have to be a plan to conduct a planning process, which in itself would be the result of planning etc. Therefore, the restrictions on 'planning' were loosened to allow for informal processes that result in an 'ad hoc plan '. This required changing from 'has_specified_output some plan specifiction' to 'has_participant some plan specification'.
definition editor: Bjoern Peters
definition source: Bjoern Peters
definition source: Plans and Planned Processes Branch
imported from: Ontology for Biomedical Investigations

hypothesis driven investigation
type: Class
subclass of: investigation
editor preferred label: hypothesis driven investigation
has curation status: pending final vetting
definition: is an investigation with the goal to test one or more hypothesis
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived
imported from: Ontology for Biomedical Investigations

hypothesis generating investigation
type: Class
subclass of: investigation
editor preferred label: hypothesis generating investigation
has curation status: pending final vetting
definition: is an investigation in which data is generated and analyzed with the purpose of generating new hypothesis
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived
imported from: Ontology for Biomedical Investigations

transfer function
type: Class
subclass of: function
editor preferred label: transfer function
has curation status: ready for release
definition: A transfer function is a function to displace a material from one location to another.
definition editor: Bill Bug
definition editor: Daniel Schober
definition editor: Frank Gibson
definition editor: Melanie Courtot
imported from: Ontology for Biomedical Investigations

extract
type: Class
subclass of: processed material
subclass of: Restriction
  on property: is_specified_output_of
  some values from: extraction
editor preferred label: extract
example of usage: Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. Cancer Res. 2008 Oct 15;68(20):8489-98. PMID: 18922923
has curation status: metadata complete
definition: an extract is a material entity which results from an extraction process
definition editor: PERSON: Philippe Rocca-Serra
alternative term: extracted material
definition source: GROUP: OBI Biomatrial Branch
imported from: Ontology for Biomedical Investigations

needle
type: Class
subclass of: device
subclass of: Restriction
  on property: has function
  some values from: transfer function
editor preferred label: needle
example of usage: Ovarian carcinoma presenting with axillary lymph node metastasis: A case diagnosed by fine-needle aspiration and brief review of the literature. Diagn Cytopathol. 2008 Oct 16. PMID: 18925569
has curation status: metadata complete
definition: A needle is a sharp, hollow device used to penetrate tissue or soft material. When attached to a syringe. it allows delivery of a specific volume of liquid or gaseous mixture.
definition editor: Philippe Rocca-Serra
definition source: OBI Instrument
imported from: Ontology for Biomedical Investigations

analyte measurement objective
type: Class
subclass of: assay objective
editor preferred label: analyte measurement objective
example of usage: The objective to measure the concentration of glucose in a blood sample
has curation status: ready for release
definition: an assay objective to determine the presence or concentration of an analyte in the evaluant
definition editor: PERSON: Bjoern Peters
definition source: PPPB branch
imported from: Ontology for Biomedical Investigations

assay objective
type: Class
subclass of: objective specification
editor preferred label: assay objective
example of usage: the objective to determine the weight of a mouse.
has curation status: ready for release
definition: an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role)
definition editor: PPPB branch
definition source: PPPB branch
imported from: Ontology for Biomedical Investigations

analyte assay
type: Class
subclass of: assay
subclass of: Restriction
  on property: has_specified_output
  some values from: measurement datum
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: analyte measurement objective
editor preferred label: analyte assay
example of usage: example of usage: In lab test for blood glucose, the test is the assay, the blood bears evaluant_role and glucose bears the analyte role. The evaluant is considered an input to the assay and the information entity that records the measurement of glucose concentration the output
has curation status: ready for release
definition: An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant.
definition editor: Alan Ruttenberg
definition editor: Bjoern Peters
definition editor: Helen Parkinson
definition editor: Philippe Rocca-Serra
definition source: Alan Ruttenberg
definition source: Bjoern Peters
definition source: Helen Parkinson
definition source: OBI Planned process branch
definition source: Philippe Rocca-Serra
imported from: Ontology for Biomedical Investigations

measure function
type: Class
subclass of: function
subclass of: Restriction
  on property: function of
  some values from: processed material
subclass of: Restriction
  on property: realized in
  all values from: Restriction
    on property: has_specified_output
    some values from: measurement datum
editor preferred label: measure function
example of usage: A glucometer measures blood glucose concentration, the glucometer has a measure function.
has curation status: ready for release
definition: Measure function is a function that is borne by a processed material and realized in a process in which information about some entity is expressed relative to some reference.
definition editor: PERSON: Daniel Schober
definition editor: PERSON: Helen Parkinson
definition editor: PERSON: Melanie Courtot
definition editor: PERSON:Frank Gibson
imported from: Ontology for Biomedical Investigations

material transformation objective
type: Class
subclass of: objective specification
editor preferred label: material transformation objective
example of usage: The objective to create a mouse infected with LCM virus. The objective to create a defined solution of PBS.
has curation status: ready for release
definition: an objective specifiction that creates an specific output object from input materials.
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Frank Gibson
definition editor: PERSON: Jennifer Fostel
definition editor: PERSON: Melanie Courtot
definition editor: PERSON: Philippe Rocca-Serra
alternative term: artifact creation objective
definition source: GROUP: OBI PlanAndPlannedProcess Branch
imported from: Ontology for Biomedical Investigations

study design execution
type: Class
equivalent class: Class
  intersection of: planned process
  intersection of: Restriction
    on property: realizes
    some values from: Restriction
      on property: concretizes
      some values from: study design
subclass of: planned process
editor preferred label: study design execution
example of usage: injecting a mouse with PBS solution, weighing it, and recording the weight according to a study design.
has curation status: ready for release
definition: a planned process that carries out a study design
editor note: removed axiom has_part some (assay or 'data transformation') per discussion on protocol application mailing list to improve reasoner performance. The axiom is still desired.
definition source: branch derived
curator note: 6/11/9: edited at workshop. Used to be: study design execution is a process with the objective to generate data according to a concretized study design. The execution of a study design is part of an investigation, and minimally consists of an assay or data transformation.
imported from: Ontology for Biomedical Investigations

clinical chemistry assay
type: Class
subclass of: analyte assay
subclass of: Class
  intersection of: Restriction
    on property: realizes
    some values from: Class
      intersection of: evaluant role
      intersection of: Restriction
        on property: role of
        some values from: bodily fluid specimen
  intersection of: Restriction
    on property: has_specified_input
    some values from: Class
      intersection of: bodily fluid specimen
      intersection of: Restriction
        on property: has role
        some values from: evaluant role
subclass of: Class
  intersection of: Restriction
    on property: realizes
    some values from: Class
      intersection of: analyte role
      intersection of: Restriction
        on property: characteristic of
        some values from: scattered molecular aggregate
  intersection of: Restriction
    on property: has_specified_input
    some values from: scattered molecular aggregate
editor preferred label: clinical chemistry assay
example of usage: Influence of hydroxyethyl starch (6% HES 130/0.4) administration on hematology and clinical chemistry parameters.
has curation status: metadata complete
definition: An analyte assay which uses analytical methods to produce measurements and data on the concentration of chemical parameters (analytes) present in a bodily fluid collected from an organism.
definition editor: Philippe Rocca-Serra
alternative term: chemical pathology
alternative term: detection of analyte in blood sample
definition source: url:https://en.wikipedia.org/wiki/Clinical_chemistry
imported from: Ontology for Biomedical Investigations

scattered molecular aggregate
type: Class
subclass of: object aggregate
subclass of: material entity
subclass of: Restriction
  on property: has grain
  some values from: molecular entity
subclass of: Restriction
  on property: has grain
  all values from: molecular entity
editor preferred label: scattered molecular aggregate
example of usage: the sodium and chloride ions in a glass of salt water
has curation status: metadata incomplete
definition: A scattered molecular aggregate is a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates
definition: a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates
definition editor: PERSON: Alan Ruttenberg
alternative term: Collective
definition source: Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. With inspiration from the paper Granularity, scale and collectivity: When size does and does not matter, Alan Recto, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349
imported from: dron.owl
imported from: Ontology for Biomedical Investigations

material separation objective
type: Class
equivalent class: Class
  union of: portioning objective
  union of: separation into different composition objective
subclass of: material transformation objective
editor preferred label: material separation objective
example of usage: The objective to obtain multiple aliquots of an enzyme preparation. The objective to obtain cells contained in a sample of blood.
has curation status: ready for release
definition: is an objective to transform a material entity into spatially separated components.
definition editor: PPPB branch
definition source: PPPB branch
imported from: Ontology for Biomedical Investigations

specimen collection process
type: Class
equivalent class: Class
  intersection of: planned process
  intersection of: Restriction
    on property: achieves_planned_objective
    some values from: specimen collection objective
subclass of: planned process
subclass of: Restriction
  on property: has_specified_input
  some values from: material entity
subclass of: Restriction
  on property: has_specified_output
  some values from: specimen
editor preferred label: specimen collection process
example of usage: drawing blood from a patient for analysis, collecting a piece of a plant for depositing in a herbarium, buying meat from a butcher in order to measure its protein content in an investigation
has curation status: ready for release
definition: A planned process with the objective of collecting a specimen.
editor note: Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.
editor note: Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role.
editor note: Philly2013: The specimen_role for the specimen is created during the specimen collection process.
editor note: label changed to 'specimen collection process' on 10/27/2014, details see tracker: http://sourceforge.net/p/obi/obi-terms/716/
definition editor: Bjoern Peters
alternative term: specimen collection
curator note: 5/31/2012: This process is not necessarily an acquisition, as specimens may be collected from materials already in posession
curator note: 6/9/09: used at workshop
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

enzyme-linked immunosorbent assay
type: Class
subclass of: analyte assay
subclass of: Class
  intersection of: Restriction
    on property: realizes
    some values from: Class
      intersection of: reagent role
      intersection of: Restriction
        on property: characteristic of
        some values from: immunoglobulin complex, circulating
  intersection of: Restriction
    on property: has_specified_input
    some values from: immunoglobulin complex, circulating
editor preferred label: enzyme-linked immunosorbent assay
example of usage: 1) Detection of IL-2 (analyte) in a cell supernatant (evaluant), using plate bound anti IL-2 antibodies, and a reporter enzyme-linked reporter antibody. 2) Measurement of IgG antibody (analyte) titer in a serum sample (evaluant) using plate bound antigen and a reporter anti-IgG antibody.
has curation status: metadata complete
definition: An analyte assay where binding of an enzyme linked antibody to a material entity that is immobilized on solid support is detected utilizing a chemiluminescent reaction. Depending on the setup, the enzyme-linked antibody could be binding directly to the analyte, or it serves as a secondary antibody detecting binding of the primary antibody to the analyte.
definition editor: IEDB
alternative term: ELISA
definition source: IEDB
imported from: Ontology for Biomedical Investigations

sample from organism
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: is_specified_output_of
    some values from: collecting specimen from organism
  intersection of: Restriction
    on property: has role
    some values from: material sample role
subclass of: material sample
subclass of: specimen from organism
subclass of: Restriction
  on property: derives from
  some values from: material anatomical entity
editor preferred label: sample from organism
has curation status: example to be eventually removed
definition: a material obtained from an organism in order to be a representative of the whole
editor note: 5/29: This is a helper class for now
editor note: we need to work on this: Is taking a urine sample a material separation process? If not, we will need to specify what 'taking a sample from organism' entails. We can argue that the objective to obtain a urine sample from a patient is enough to call it a material separation process, but it could dilute what material separation was supposed to be about.
imported from: Ontology for Biomedical Investigations

portioning objective
type: Class
subclass of: material separation objective
editor preferred label: portioning objective
example of usage: The objective to obtain multiple aliquots of an enzyme preparation.
has curation status: metadata incomplete
definition: A material separation objective aiming to separate material into multiple portions, each of which contains a similar composition of the input material.
imported from: Ontology for Biomedical Investigations

separation into different composition objective
type: Class
subclass of: material separation objective
editor preferred label: separation into different composition objective
example of usage: The objective to obtain cells contained in a sample of blood.
has curation status: metadata complete
definition: A material separation objective aiming to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities).
editor note: We should be using has the grain relations or concentrations to distinguish the portioning and other sub-objectives
imported from: Ontology for Biomedical Investigations

specimen collection objective
type: Class
subclass of: objective specification
editor preferred label: specimen collection objective
example of usage: The objective to collect bits of excrement in the rainforest. The objective to obtain a blood sample from a patient.
has curation status: ready for release
definition: A objective specification to obtain a material entity for potential use as an input during an investigation.
definition editor: Bjoern Peters
definition source: Bjoern Peters
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

material sample role
type: Class
subclass of: specimen role
editor preferred label: material sample role
example of usage: a role borne by a portion of blood taken to represent all the blood in an organism; the role borne by a population of humans with HIV enrolled in a study taken to represent patients with HIV in general.
has curation status: pending final vetting
definition: A material sample role is a specimen role borne by a material entity that is the output of a material sampling process.
editor note: 7/13/09: Note that this is a relational role: between the sample taken and the 'sampled' material of which the sample is thought to be representative off.
imported from: Ontology for Biomedical Investigations

material sample
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: has role
    some values from: material sample role
subclass of: specimen
editor preferred label: material sample
example of usage: blood drawn from patient to measure his systemic glucose level. A population of humans with HIV enrolled in a study taken to represent patients with HIV in general.
has curation status: metadata incomplete
definition: A material entity that has the material sample role
definition editor: OBI: workshop
alternative term: sample population
imported from: Ontology for Biomedical Investigations
ISA alternative term: sample

material maintenance objective
type: Class
subclass of: objective specification
editor preferred label: material maintenance objective
has curation status: ready for release
definition: An objective specification maintains some or all of the qualities of a material over time.
definition editor: PERSON: Bjoern Peters
definition source: PERSON: Bjoern Peters
imported from: Ontology for Biomedical Investigations

informed consent process
type: Class
subclass of: planned process
subclass of: Restriction
  on property: has_specified_input
  some values from: Homo sapiens
subclass of: Restriction
  on property: has_participant
  some values from: Restriction
    on property: has role
    some values from: investigation agent role
editor preferred label: informed consent process
has curation status: ready for release
definition: A planned process in which a person or their legal representative is informed about key facts about potential risks and benefits of a process and makes a documented decision as to whether the person in question will participate.
editor note: 09/28/2009 Alan Ruttenberg: This is made a subclass of the higher level processual entity in BFO because I don't want to take a stand on whether it is a process aggregate. Analogous to the situation with Material entity.
definition editor: Person:Alan Ruttenberg
definition source: http://clinicaltrials.gov/ct2/info/glossary#informed
curator note: 2009/09/28 Alan Ruttenberg. Fucoidan-use-case
imported from: Ontology for Biomedical Investigations

measurement device
type: Class
equivalent class: Class
  intersection of: device
  intersection of: Restriction
    on property: has function
    some values from: measure function
subclass of: device
editor preferred label: measurement device
example of usage: A ruler, a microarray scanner, a Geiger counter.
has curation status: ready for release
definition: A device in which a measure function inheres.
definition editor: GROUP:OBI Philly workshop
definition source: OBI
imported from: Ontology for Biomedical Investigations

material maintenance
type: Class
equivalent class: Restriction
  on property: achieves_planned_objective
  some values from: material maintenance objective
subclass of: planned process
editor preferred label: material maintenance
has curation status: metadata incomplete
definition: a process with that achieves the objective to maintain some or all of the characteristics of an input material over time
imported from: Ontology for Biomedical Investigations

categorical measurement datum
type: Class
subclass of: measurement datum
subclass of: Restriction
  on property: has value specification
  some values from: categorical value specification
editor preferred label: categorical measurement datum
has curation status: metadata complete
definition: A measurement datum that is reported on a categorical scale
definition editor: Bjoern Peters
alternative term: nominal mesurement datum
definition source: Bjoern Peters
imported from: Ontology for Biomedical Investigations

service consumer role
type: Class
subclass of: role
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    union of: Homo sapiens
    union of: organization
editor preferred label: service consumer role
example of usage: A biologist who uses a sequencing services fulfills the role of a service consumer
has curation status: metadata complete
definition: a role which inheres in a person who uses a service
definition editor: Person:Helen Parkinson
definition source: OBI
imported from: Ontology for Biomedical Investigations

service provider role
type: Class
subclass of: role
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    union of: Homo sapiens
    union of: organization
subclass of: Restriction
  on property: realized in
  all values from: planned process
editor preferred label: service provider role
example of usage: Jackson Lab provides experimental animals, EBI provides training on databases, a core facility provides access to a DNA sequencer.
has curation status: metadata incomplete
definition: is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person
definition editor: PERSON:Helen Parkinson
imported from: Ontology for Biomedical Investigations

processed specimen
type: Class
equivalent class: Class
  intersection of: processed material
  intersection of: specimen
subclass of: processed material
subclass of: specimen
editor preferred label: processed specimen
example of usage: A tissue sample that has been sliced and stained for a histology study. A blood specimen that has been centrifuged to obtain the white blood cells.
has curation status: ready for release
definition: A specimen that has been intentionally physically modified.
definition editor: Bjoern Peters
definition source: Bjoern Peters
imported from: Ontology for Biomedical Investigations
comment: A tissue sample that has been sliced and stained for a histology study.

device
type: Class
subclass of: processed material
subclass of: Restriction
  on property: is_specified_output_of
  some values from: material processing
subclass of: Restriction
  on property: has function
  some values from: function
editor preferred label: device
example of usage: A voltmeter is a measurement device which is intended to perform some measure function.
example of usage: An autoclave is a device that sterlizes instruments or contaminated waste by applying high temperature and pressure.
has curation status: ready for release
definition: A material entity that is designed to perform a function in a scientific investigation, but is not a reagent.
editor note: 2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of "device", and are enumerating the types of roles that a reagent can perform. 2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions. Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear. For example: (1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component. This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part. (2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay. (3) A gel running box is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it. This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel. In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent…
definition editor: PERSON: Helen Parkinson
alternative term: instrument
definition source: OBI development call 2012-12-17.
imported from: Ontology for Biomedical Investigations

sequence data
type: Class
subclass of: measurement datum
subclass of: Class
  intersection of: measurement datum
  intersection of: Restriction
    on property: is about
    some values from: region
editor preferred label: sequence data
example of usage: example of usage: the representation of a nucleotide sequence in FASTA format used for a sequence similarity search.
has curation status: metadata complete
definition: A measurement datum that representing the primary structure of a macromolecule(it's sequence) sometimes associated with an indicator of confidence of that measurement.
definition editor: Person:Chris Stoeckert
definition source: GROUP: OBI
imported from: Ontology for Biomedical Investigations

dose
type: Class
subclass of: measurement datum
editor preferred label: dose
example of usage: An organism has been injected 1ml of vaccine
has curation status: metadata incomplete
definition: A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses.
imported from: Ontology for Biomedical Investigations

nucleic acid extract
type: Class
subclass of: extract
subclass of: processed specimen
subclass of: Class
  intersection of: Restriction
    on property: is_specified_output_of
    some values from: nucleic acid extraction
  intersection of: Restriction
    on property: has role
    some values from: specimen role
subclass of: Restriction
  on property: has grain
  some values from: nucleic acid
editor preferred label: nucleic acid extract
has curation status: metadata complete
definition: An extract that is the output of an extraction process in which nucleic acid molecules are isolated from a specimen.
definition editor: PERSON: Jie Zheng
definition source: UPenn Group
imported from: Ontology for Biomedical Investigations

nucleic acid sequencer
type: Class
subclass of: measurement device
subclass of: Restriction
  on property: has function
  some values from: measure function
editor preferred label: nucleic acid sequencer
has curation status: metadata complete
definition: An device that is used to determine the order of nucleotides in nucleic acid sequences.
definition editor: PERSON: Erik Segerdell
definition source: PERSON: Erik Segerdell
imported from: Ontology for Biomedical Investigations

protein sequencer
type: Class
subclass of: measurement device
subclass of: Restriction
  on property: has function
  some values from: measure function
editor preferred label: protein sequencer
has curation status: metadata complete
definition: An device that is used to determine the order of amino acids in protein sequences.
definition editor: PERSON: Erik Segerdell
definition source: PERSON: Erik Segerdell
imported from: Ontology for Biomedical Investigations

service
type: Class
equivalent class: Class
  intersection of: planned process
  intersection of: Class
    intersection of: Restriction
      on property: realizes
      some values from: service consumer role
    intersection of: Restriction
      on property: realizes
      some values from: service provider role
subclass of: planned process
subclass of: Restriction
  on property: has part
  some values from: planned process
editor preferred label: service
example of usage: providing a training course for UCSD employees how to run a DNA sequencer; sequencing a DNA sample provided by a service consumer restricted to non-human samples; giving access to tissue samples in a biobank within OHSU; JAX shipping mice from their colony
has curation status: metadata complete
definition: A planned process in which a service provider performs a task (i.e. a planned process) for a service consumer.
definition editor: Carlo; Matt
definition source: OBI workshop San Diego 2011
imported from: Ontology for Biomedical Investigations

specimen from organism
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: has role
    some values from: specimen role
  intersection of: Restriction
    on property: derives from
    some values from: Class
      union of: material anatomical entity
      union of: anatomical cluster
subclass of: specimen
editor preferred label: specimen from organism
has curation status: ready for release
definition: A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm).
definition editor: PERSON: Chris Stoeckert, Jie Zheng
alternative term: tissue specimen
definition source: MO_954 organism_part
imported from: Ontology for Biomedical Investigations

material maintenance service
type: Class
equivalent class: Class
  intersection of: material service
  intersection of: Restriction
    on property: provides_service_consumer_with
    some values from: material maintenance
subclass of: material service
editor preferred label: material maintenance service
example of usage: model organism colony maintanance
has curation status: pending final vetting
definition: A material processing service in which a service provider makes physical modifications to a specified input material, such that at least one of the specified outputs of this process is a modified version of a specified input material.
definition editor: PERSON: Carlo Torniai
definition editor: PERSON: Matthew Brush
definition source: PERSON: Matthew Brush
imported from: Ontology for Biomedical Investigations
comment: Here we need to go back to the defintoin of storage process. It has object specification which is material maintenance. Not necessareley a material maintenance is needed in a storage process.

material service
type: Class
equivalent class: Class
  intersection of: service
  intersection of: Restriction
    on property: provides_service_consumer_with
    some values from: Class
      union of: Restriction
        on property: has_specified_input
        some values from: material entity
      union of: Restriction
        on property: has_specified_output
        some values from: material entity
subclass of: service
editor preferred label: material service
example of usage: A service performing DNA sequencing, a service preforming cell analysis. A service performing cell line immortalization
has curation status: pending final vetting
definition: A service which has a material entity as specified input and/or specified output.
definition editor: PERSON: Carlo Torniai
definition editor: PERSON: Matthew Brush
definition source: PERSON: Carlo Torniai
imported from: Ontology for Biomedical Investigations

material analysis service
type: Class
equivalent class: Class
  intersection of: material service
  intersection of: Restriction
    on property: provides_service_consumer_with
    some values from: assay
subclass of: material service
editor preferred label: material analysis service
example of usage: Services performing DNA sequencing or Cell Analysis
has curation status: pending final vetting
definition: A service in which a service consumer provides some input material and a service provider performs some analysis of this material to generate data that is returned to the service consumer.
definition editor: PERSON: Carlo Torniai
definition editor: PERSON: Matthew Brush
definition source: PERSON: Matthew Brush
imported from: Ontology for Biomedical Investigations

material storage service
type: Class
equivalent class: Class
  intersection of: material service
  intersection of: Restriction
    on property: provides_service_consumer_with
    some values from: storage
subclass of: material maintenance service
editor preferred label: material storage service
example of usage: A service that offers liquid nitrogen stroage.
has curation status: pending final vetting
definition: A storage service in which a service consumer provides some material as input which a service provider stores and returns as output.
definition editor: PERSON: Carlo Torniai
definition editor: PERSON: Matthew Brush
definition source: PERSON: Matthew Brush
imported from: Ontology for Biomedical Investigations

specimen identifier
type: Class
subclass of: centrally registered identifier symbol
subclass of: Restriction
  on property: denotes
  all values from: specimen
editor preferred label: specimen identifier
has curation status: metadata complete
definition: A CRID symbol denotes a specimen and used to distinguish one specimen from another in an investigation.
definition editor: Person: Chris Stoeckert, Jie Zheng
alternative term: specimen ID
definition source: NIAID GSCID-BRC metadata working group
imported from: Ontology for Biomedical Investigations
NIAID GSCID-BRC alternative term: Specimen ID
Source: NIAID GSCID-BRC

selection criterion
type: Class
subclass of: directive information entity
editor preferred label: selection criterion
example of usage: rats should be aged between 6 and 8 weeks and weight between 180-250grams
has curation status: ready for release
definition: A directive information entity which defines and states a principle of standard by which selection process may take place.
definition editor: Person: Philippe Rocca-Serra
alternative term: selection rule
definition source: OBI discussion summarized under the following tracker item : http://sourceforge.net/p/obi/obi-terms/678/
imported from: Ontology for Biomedical Investigations

specimen repository organization
type: Class
equivalent class: Class
  intersection of: organization
  intersection of: Restriction
    on property: has role
    some values from: Class
      intersection of: service provider role
      intersection of: Restriction
        on property: realized in
        some values from: Class
subclass of: organization
editor preferred label: specimen repository organization
has curation status: metadata complete
definition: An organization that provides a service to store and distribute specimens
definition editor: PERSON: Chris Stoeckert, Jie Zheng
definition source: NIAID GSCID-BRC metadata working group
imported from: Ontology for Biomedical Investigations
NIAID GSCID-BRC alternative term: Specimen Repository
Source: NIAID GSCID-BRC

sequencing facility organization
type: Class
equivalent class: Class
  intersection of: organization
  intersection of: Restriction
    on property: has role
    some values from: Class
      intersection of: service provider role
      intersection of: Restriction
        on property: realized in
        some values from: sequencing service
subclass of: molecular analysis facility organization
editor preferred label: sequencing facility organization
has curation status: metadata complete
definition: An organization that provides sequence determination service
definition editor: PERSON: Chris Stoeckert, Jie Zheng
definition source: NIAID GSCID-BRC metadata working group
imported from: Ontology for Biomedical Investigations
NIAID GSCID-BRC alternative term: Sequencing Facility
Source: NIAID GSCID-BRC

comment on investigation
type: Class
equivalent class: Class
  intersection of: textual entity
  intersection of: Restriction
    on property: is about
    some values from: Class
      union of: investigation
      union of: Restriction
        on property: part of
        some values from: investigation
      union of: Restriction
        on property: participates in
        some values from: investigation
subclass of: textual entity
editor preferred label: comment on investigation
has curation status: metadata complete
definition: A textual entity that is about any of the aspects of an investigation worth noting
definition editor: PERSON: Chris Stoeckert, Jie Zheng
definition source: NIAID GSCID-BRC metadata working group
imported from: Ontology for Biomedical Investigations
NIAID GSCID-BRC alternative term: Comments
Source: NIAID GSCID-BRC

specimen identifier assigned by specimen repository
type: Class
equivalent class: Class
  intersection of: specimen identifier
  intersection of: Restriction
    on property: is_specified_output_of
    some values from: Class
      intersection of: assigning a centrally registered identifier
      intersection of: Restriction
        on property: has_participant
        some values from: specimen repository organization
subclass of: specimen identifier
editor preferred label: specimen identifier assigned by specimen repository
has curation status: metadata complete
definition: A specimen identifier which is assigned by a specimen repository
definition editor: PERSON: Chris Stoeckert, Jie Zheng
definition source: NIAID GSCID-BRC metadata working group
imported from: Ontology for Biomedical Investigations
NIAID GSCID-BRC alternative term: Specimen Repository Sample ID
Source: NIAID GSCID-BRC

specimen identifier assigned by sequencing facility
type: Class
equivalent class: Class
  intersection of: specimen identifier
  intersection of: Restriction
    on property: is_specified_output_of
    some values from: Class
      intersection of: assigning a centrally registered identifier
      intersection of: Restriction
        on property: has_participant
        some values from: sequencing facility organization
subclass of: specimen identifier
editor preferred label: specimen identifier assigned by sequencing facility
has curation status: metadata complete
definition: A specimen identifier which is assigned by a sequencing facility
definition editor: PERSON: Chris Stoeckert, Jie Zheng
definition source: NIAID GSCID-BRC metadata working group
imported from: Ontology for Biomedical Investigations
NIAID GSCID-BRC alternative term: Sample ID - Sequencing Facility
Source: NIAID GSCID-BRC

sequencing service
type: Class
equivalent class: Class
  intersection of: material service
  intersection of: Restriction
    on property: provides_service_consumer_with
    some values from: sequencing assay
subclass of: material analysis service
editor preferred label: sequencing service
has curation status: metadata complete
definition: A service provides sequencing service which is the realization of some sequencing such as RNA and DNA sequencing in which the service provider role is realized.
definition editor: Person: Jie Zheng
definition source: Adpated from 'DNA sequencing service'
imported from: Ontology for Biomedical Investigations
Source: NIAID GSCID-BRC

conclusion based on data
type: Class
subclass of: information content entity
subclass of: Restriction
  on property: is_supported_by_data
  some values from: data item
subclass of: Restriction
  on property: is_specified_output_of
  some values from: drawing a conclusion based on data
editor preferred label: conclusion based on data
example of usage: The conclusion that a gene is upregulated in a tissue sample based on the band intensity in a western blot. The conclusion that a patient has a infection based on measurement of an elevated body temperature and reported headache. The conclusion that there were problems in an investigation because data from PCR and microarray are conflicting. The following are NOT conclusions based on data: data themselves; results from pure mathematics, e.g. "13 is prime".
has curation status: ready for release
definition: An information content entity that is inferred from data.
editor note: In the Philly 2013 workshop, we recognized the limitations of "conclusion textual entity", and we introduced this as more general. The need for the 'textual entity' term going forward is up for future debate.
definition editor: Group:2013 Philly Workshop group
definition source: Group:2013 Philly Workshop group
imported from: Ontology for Biomedical Investigations

cell freezing medium
type: Class
subclass of: processed material
editor preferred label: cell freezing medium
has curation status: metadata complete
definition: A processed material that serves as a liquid vehicle for freezing cells for long term quiescent stroage, which contains chemicls needed to sustain cell viability across freeze-thaw cycles.
definition editor: PERSON: Matthew Brush
imported from: Ontology for Biomedical Investigations

selection
type: Class
equivalent class: Restriction
  on property: realizes
  some values from: Restriction
    on property: concretizes
    some values from: selection criterion
subclass of: planned process
editor preferred label: selection
example of usage: PMID: 24023800. In this study, a set of eleven genes (VATP16, 60 S, UQCC, SMD3, EF1α, UBQ, SAND, GAPDH, ACT, PsaB, PTB2) was evaluated to identify reference genes during the first hours of interaction (6, 12, 18 and 24 hpi) between two V. vinifera genotypes and P. viticola. Two analyses were used for the selection of reference genes: direct comparison of susceptible, Trincadeira, and resistant, Regent, V. vinifera cultivars at 0 h, 6, 12, 18 and 24 hours post inoculation with P. viticola (genotype effect); and comparison of each genotype with mock inoculated samples during inoculation time-course (biotic stress effect). Three statistical methods were used, GeNorm, NormFinder, and BestKeeper, allowing to identify UBQ, EF1α and GAPDH as the most stable genes for the genotype effect.
has curation status: ready for release
definition: A planned process which results in the creation of group of entity from a larger group by the application of predefined criteria.
editor note: this term refers to a planned process and therefore is distinct from the notion of 'natural selection', a process covering the operation of natural causes by which those individuals of a species that are best adapted to the environment tend to be preserved and to transmit their characters, while those less adapted die out, so that in the course of generations the degree of adaptation to the environment tends progressively to increase. (as defined by Oxford English Dictionary)
definition editor: Person: Philippe Rocca-Serra
alternative term: selection process
definition source: OBI
imported from: Ontology for Biomedical Investigations

categorical value specification
type: Class
subclass of: value specification
editor preferred label: categorical value specification
has curation status: metadata incomplete
definition: A value specification that is specifies one category out of a fixed number of nominal categories
definition editor: PERSON:Bjoern Peters
imported from: Ontology for Biomedical Investigations

value specification
type: Class
subclass of: information content entity
editor preferred label: value specification
example of usage: The value of 'positive' in a classification scheme of "positive or negative"; the value of '20g' on the quantitative scale of mass.
has curation status: ready for release
definition: An information content entity that specifies a value within a classification scheme or on a quantitative scale.
editor note: This term is currently a descendant of 'information content entity', which requires that it 'is about' something. A value specification of '20g' for a measurement data item of the mass of a particular mouse 'is about' the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change 'value specification' to remove the 'is about' requirement.
definition editor: PERSON:Bjoern Peters
imported from: Ontology for Biomedical Investigations

molecular analysis facility organization
type: Class
equivalent class: Class
  intersection of: organization
  intersection of: Restriction
    on property: has role
    some values from: Class
      intersection of: service provider role
      intersection of: Restriction
        on property: realized in
        some values from: material analysis service
subclass of: organization
editor preferred label: molecular analysis facility organization
example of usage: An analysis facility that includes analysis of molecular metabolites, as well as the various DNAs and RNAs.
has curation status: ready for release
definition: An organization that provides molecular analysis service.
definition editor: Chris Stoeckert, Helena Ellis
alternative term: MAF
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

age of majority inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: age of majority inclusion criterion
has curation status: metadata complete
definition: An inclusion criterion that uses the age of majority for a state or institution, where one is generally considered to be an adult, which if met, makes an individual suitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

chemotherapy treatment exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: chemotherapy treatment exclusion criterion
has curation status: metadata complete
definition: An exclusion criterion that defines whether chemotherapy was received or is being received for a previous or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

radiation treatment exclusion criteria
type: Class
subclass of: exclusion criterion
editor preferred label: radiation treatment exclusion criteria
has curation status: metadata complete
definition: An exclusion criterion that defines whether radiation was received or is being received for a previous or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

chemotherapy treatment within the recent past exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: chemotherapy treatment within the recent past exclusion criterion
example of usage: An exclusion criterion defined by the pathologist is defined as whether the individual received chemotherapy within the last two years.
has curation status: metadata complete
definition: An exclusion criterion that defines whether chemotherapy was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

radiation treatment within the recent past exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: radiation treatment within the recent past exclusion criterion
example of usage: An exclusion criterion defined by the pathologist is defined as whether the individual received radiation therapy within the last two years.
has curation status: metadata complete
definition: An exclusion criterion that defines whether radiation was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

BMI range inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: BMI range inclusion criterion
example of usage: An important inclusion criterion is for for the individual to have a BMI between 18.5 and 35.0
has curation status: metadata complete
definition: An inclusion criterion that defines and states a Body Mass Index range, which if met, makes an individual suitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

blood transfusion exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: blood transfusion exclusion criterion
example of usage: An exclusion criterion that is defined by whether the specimen donor received a whole blood transfusion within 48 hours prior to death.
has curation status: metadata complete
definition: An exclusion criterion that is defined by whether the specimen donor received a whole blood transfusion within a specified time frame prior to death, which if met, makes a specimen donor unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

history of metastatic cancer exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: history of metastatic cancer exclusion criterion
has curation status: metadata complete
definition: An exclusion criterion defined as whether an individual has ever been diagnosed with metastatic cancer (cancer that spread beyond the initial site such as to other organs like brain bone or liver), which if met, makes the individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

intravenous drug use exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: intravenous drug use exclusion criterion
example of usage: Donor eligibility based on history of intravenous drug abuse in the last 5 years.
has curation status: metadata complete
definition: An exclusion criterion defined as when an individual has a history of intravenous drug abuse for a specific timeframe, which if met, makes the individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

history of sex with someone with a history of blood borne infection exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: history of sex with someone with a history of blood borne infection exclusion criterion
example of usage: Donor eligibility based on whether the donor has a history of sex with someone who has been diagnosed or at risk for HIV/AIDS and/or HCV and/or HBV in the last 5 years.
has curation status: metadata complete
definition: An exclusion criterion defined as whether an individual has a history of sex with someone who has been diagnosed or at risk for a blood borne infections disease in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

history of sex with someone with a history of intravenous drugs exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: history of sex with someone with a history of intravenous drugs exclusion criterion
example of usage: Donor eligibility based on whether the donor has a history of sex with someone who has used intravenous drugs in the last 5 years.
has curation status: metadata complete
definition: An exclusion criterion defined as whether an individual has a history of sex with someone who has used intravenous drugs in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

HIV exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: HIV exclusion criterion
has curation status: metadata complete
definition: An exclusion criterion defined as whether an individual has a history of repeatedly reactive screening assays for HIV-1 or HIV-2 antibody regardless of the results of supplemental assays, which if met, makes the individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

exposure to blood borne infectious disease exclusion criterion
type: Class
subclass of: exclusion criterion
editor preferred label: exposure to blood borne infectious disease exclusion criterion
example of usage: Donor eligibility based on whether the donor has been exposed to HIV/AIDS.
has curation status: metadata complete
definition: An exclusion criterion defined as whether an individual has been exposed to a blood borne infections disease through needle sticks and/or contact with non-intact skin and/or contact with open wounds and/or contact with mucous membranes, which if met, makes the individual unsuitable for a given task or participation in a given process.
definition editor: Chris Stoeckert, Helena Ellis
definition source: NCI BBRB, OBIB
ontology term requester: NCI BBRB
imported from: Ontology for Biomedical Investigations

measurand role
type: Class
subclass of: role
subclass of: Restriction
  on property: role of
  some values from: material entity
editor preferred label: measurand role
has curation status: metadata complete
definition: A role borne by a material entity and realized in an assay which achieves the objective to measure the magnitude/concentration/amount of the measurand in the entity bearing evaluant role.
definition editor: Person: Alan Ruttenberg, Jie Zheng
definition source: https://en.wiktionary.org/wiki/measurand
term tracker item: https://github.com/obi-ontology/obi/issues/778
imported from: Ontology for Biomedical Investigations

health status inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: health status inclusion criterion
example of usage: ‘diagnosed with Type 2 diabetes mellitus’, ‘E11.4’, ’not finding of hypertension'
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states one or more clinically significant bodily components, dispositions, and/or bodily processes of an entity that are inferred from relevant clinical findings or self-reported, which, if met, makes the entity suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
ontology term requester: MIABIS2.0
imported from: Ontology for Biomedical Investigations

clinically relevant lifestyle inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: clinically relevant lifestyle inclusion criterion
example of usage: 'smoking behavior’
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states one or more clinically relevant planned processes that a human being actively participates in , which, if met, makes the human being suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
ontology term requester: MIABIS2.0
imported from: Ontology for Biomedical Investigations

clinically relevant exposure inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: clinically relevant exposure inclusion criterion
example of usage: 'exposure to cigarette smoke’, ‘exposure to lead through drinking water'
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states one or more clinically relevant histories of exposure of an entity, which, if met, makes the entity suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
ontology term requester: MIABIS2.0
imported from: Ontology for Biomedical Investigations

gravidity inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: gravidity inclusion criterion
example of usage: 'pregnant’, ‘not pregnant'
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states one or more gravidity statuses of an organism, which, if met, makes the entity suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
ontology term requester: MIABIS2.0
imported from: Ontology for Biomedical Investigations

defined population inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: defined population inclusion criterion
example of usage: inclusion based on age, sex, and living region (rural area or specified city).
has curation status: metadata complete
definition: An inclusion criterion that is based on fitting within the defined characteristics of a population based study design.
definition editor: Chris Stoeckert, Mathias Brochhausen
definition source: MIABIS 2.0
term tracker item: 920
ontology term requester: MIABIS 2.0
imported from: Ontology for Biomedical Investigations

age group inclusion criterion
type: Class
subclass of: inclusion criterion
subclass of: Class
  intersection of: Restriction
    on property: has part
    some values from: minimum age value specification
  intersection of: Restriction
    on property: has part
    some values from: maximum age value specification
editor preferred label: age group inclusion criterion
example of usage: "18-33 years old"
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states an age bracket which, if met, makes an entity suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
term tracker item: #839
imported from: Ontology for Biomedical Investigations

minimum age value specification
type: Class
subclass of: value specification
editor preferred label: minimum age value specification
has curation status: metadata incomplete
definition: A value specifcation that specifies the youngest age when specifying an age range.
definition editor: Mathias Brochhausen
imported from: Ontology for Biomedical Investigations

maximum age value specification
type: Class
subclass of: value specification
editor preferred label: maximum age value specification
has curation status: metadata incomplete
definition: A value specifcation that specifies the oldest age when specifying an age range.
definition editor: Mathias Brochhausen
imported from: Ontology for Biomedical Investigations

use of medication inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: use of medication inclusion criterion
example of usage: "received at least 2 days of vancomycin"
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states a a set of medications, which, if used by an entity, makes that entity suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
term tracker item: #840
imported from: Ontology for Biomedical Investigations

hospital patient inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: hospital patient inclusion criterion
example of usage: "included hospital patients"
has curation status: metadata incomplete
definition: An inclusion criterion defines that a human being has to be a hospital patient to be suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
imported from: Ontology for Biomedical Investigations

family status inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: family status inclusion criterion
example of usage: "included married and unmarried patients", "included divorced individuals"
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states one or more family statuses, which, if met, makes a human being suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
imported from: Ontology for Biomedical Investigations

sex inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: sex inclusion criterion
example of usage: "included males and females", "included male patients"
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states one or more sexes which, if met, makes an entity suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
imported from: Ontology for Biomedical Investigations

country of residence inclusion criteria
type: Class
subclass of: inclusion criterion
editor preferred label: country of residence inclusion criteria
example of usage: "include US residents"
has curation status: metadata incomplete
definition: An inclusion criterion that defines and states one or more countries of residence which, if met, makes a human being suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
imported from: Ontology for Biomedical Investigations

ethnicity inclusion criterion
type: Class
subclass of: inclusion criterion
editor preferred label: ethnicity inclusion criterion
example of usage: "include only Hispanic individuals"
has curation status: metadata incomplete
definition: An inclusion criteria that defines and states one or more ethnicities which, if met, makes an entity suitable for a given task or participation in a given process.
definition editor: Mathias Brochhausen
imported from: Ontology for Biomedical Investigations

organism
type: Class
equivalent class: Class
  union of: Viruses
  union of: Bacteria
  union of: Archaea
  union of: Eukaryota
subclass of: object
subclass of: material entity
editor preferred label: organism
example of usage: animal
example of usage: fungus
example of usage: plant
example of usage: virus
has curation status: organizational term
has curation status: ready for release
definition: A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
editor note: 10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms')
editor note: 13-02-2009: OBI doesn't take position as to when an organism starts or ends being an organism - e.g. sperm, foetus. This issue is outside the scope of OBI.
definition editor: GROUP: OBI Biomaterial Branch
definition source: WEB: http://en.wikipedia.org/wiki/Organism
imported from: dron.owl
imported from: envo.owl
imported from: Ontology for Biomedical Investigations
imported from: omrse.owl

specimen
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Restriction
    on property: has role
    some values from: specimen role
subclass of: material entity
editor preferred label: specimen
example of usage: Biobanking of blood taken and stored in a freezer for potential future investigations stores specimen.
has curation status: ready for release
definition: A material entity that has the specimen role.
editor note: Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.
definition editor: PERSON: James Malone
definition editor: PERSON: Philippe Rocca-Serra
definition source: GROUP: OBI Biomaterial Branch
imported from: Ontology for Biomedical Investigations
imported from: obib.owl

cultured cell population
type: Class
subclass of: processed material
subclass of: Restriction
  on property: is_specified_output_of
  some values from: maintaining cell culture
subclass of: Restriction
  on property: has grain
  some values from: cultured cell
subclass of: Restriction
  on property: has grain
  all values from: cultured cell
editor preferred label: cultured cell population
example of usage: A cultured cell population applied in an experiment: "293 cells expressing TrkA were serum-starved for 18 hours and then neurotrophins were added for 10 min before cell harvest." (Lee, Ramee, et al. "Regulation of cell survival by secreted proneurotrophins." Science 294.5548 (2001): 1945-1948). A cultured cell population maintained in vitro: "Rat cortical neurons from 15 day embryos are grown in dissociated cell culture and maintained in vitro for 8–12 weeks" (Dichter, Marc A. "Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation." Brain Research 149.2 (1978): 279-293).
has curation status: metadata complete
definition: A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history.
editor note: 2013-6-5 MHB: This OBI class was formerly called 'cell culture', but label changed and definition updated following CLO alignment efforts in spring 2013, during which the intent of this class was clarified to refer to portions of a culture or line rather than a complete cell culture or line.
definition editor: PERSON:Matthew Brush
alternative term: cell culture sample
definition source: PERSON:Matthew Brush
imported from: Ontology for Biomedical Investigations
comment: The extent of a 'cultured cell population' is restricted only in that all cell members must share a propagation history (ie be derived through a common lineage of passages from an initial culture). In being defined in this way, this class can be used to refer to the populations that researchers actually use in the practice of science - ie are the inputs to culturing, experimentation, and sharing. The cells in such populations will be a relatively uniform population as they have experienced similar selective pressures due to their continuous co-propagation. And this population will also have a single passage number, again owing to their common passaging history. Cultured cell populations represent only a collection of cells (ie do not include media, culture dishes, etc), and include populations of cultured unicellular organisms or cultured multicellular organism cells. They can exist under active culture, stored in a quiescent state for future use, or applied experimentally.

extraction
type: Class
subclass of: material component separation
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: separation into different composition objective
editor preferred label: extraction
example of usage: nucleic acid extraction using phenol chloroform
has curation status: metadata incomplete
definition: A material separation in which a desired component of an input material is separated from the remainder
editor note: Current the output of material processing defined as the molecular entity, main component in the output material entity, rather than the material entity that have grain molecular entity. 'nucleic acid extract' is the output of 'nucleic acid extraction' and has grain 'nucleic acid'. However, the output of 'nucleic acid extraction' is 'nucleic acid' rather than 'nucleic acid extract'. We are aware of this issue and will work it out in the future.
definition editor: Person:Bjoern Peters
definition editor: Philippe Rocca-Serra
imported from: Ontology for Biomedical Investigations

storage
type: Class
subclass of: material maintenance
subclass of: Restriction
  on property: has_specified_input
  some values from: material entity
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: material maintenance objective
editor preferred label: storage
example of usage: PMID: 18550121.Total Prostate Specific Antigen Stability Confirmed After Long-Term Storage of Serum at -80C. J Urol. 2008 Jun 10.
has curation status: metadata complete
definition: A maintenance process by which material entities that are not actively metabolizing are placed in well identified location and possibly under controlled environment in ad-hoc devices/structures in order to preserve and protect them from decay/alteration and maintain availability
definition editor: Philippe Rocca-Serra
definition source: OBI-Branch
imported from: Ontology for Biomedical Investigations

DNA sequencer
type: Class
subclass of: measurement device
subclass of: Restriction
  on property: has function
  some values from: measure function
editor preferred label: DNA sequencer
example of usage: ABI 377 DNA Sequencer, ABI 310 DNA Sequencer
has curation status: ready for release
definition: A DNA sequencer is an instrument that determines the order of deoxynucleotides in deoxyribonucleic acid sequences.
definition editor: Trish Whetzel
definition source: MO
imported from: Ontology for Biomedical Investigations

study design
type: Class
subclass of: plan specification
subclass of: Restriction
  on property: has part
  some values from: protocol
editor preferred label: study design
example of usage: a matched pairs study design describes criteria by which subjects are identified as pairs which then undergo the same protocols, and the data generated is analyzed by comparing the differences between the paired subjects, which constitute the results of the executed study design.
has curation status: ready for release
definition: A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution.
editor note: Editor note: there is at least an implicit restriction on the kind of data transformations that can be done based on the measured data available.
definition editor: PERSON: Chris Stoeckert
alternative term: experimental design
curator note: rediscussed at length (MC/JF/BP). 12/9/08). The definition was clarified to differentiate it from protocol.
imported from: Ontology for Biomedical Investigations

eligibility criterion
type: Class
subclass of: selection criterion
editor preferred label: eligibility criterion
example of usage: PMID: 17579629 -Eligibility criteria included: untreated ED-SCLC; age >/=70 and performance status 0-2, or age <70 and PS 3.
has curation status: ready for release
definition: an eligibility criterion (rule) is_a selection criterion which defines and states the requirements (positive or negative) for an entity to be considered as suitable for a given task or participation in a process.
definition editor: Person: Philippe Rocca-Serra
alternative term: eligibility rule
definition source: Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group
imported from: Ontology for Biomedical Investigations

inclusion criterion
type: Class
subclass of: eligibility criterion
editor preferred label: inclusion criterion
example of usage: PMID: 23979341-The major inclusion criterion was patients in whom severe cerebral embolism was diagnosed at age 75 or younger (more than 9 in the NIHSS score on day 7 after the onset of stroke) .
has curation status: pending final vetting
definition: an inclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity suitable for a given task or participation in a given process. For instance, in a study protocol, inclusion criteria indicate the conditions that prospective subjects MUST meet to be eligible for participation in a study.
definition editor: Person: Philippe Rocca-Serra
alternative term: inclusion condition
alternative term: inclusion rule
definition source: Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group
imported from: Ontology for Biomedical Investigations

exclusion criterion
type: Class
subclass of: eligibility criterion
editor preferred label: exclusion rule
example of usage: PMID: 17600285-Exclusion criteria included the use of any topical ophthalmic or topical oral medication and/or history of ocular or oral surgery within the past six months.
has curation status: pending final vetting
definition: an exclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity unsuitable for a given task or participation in a given process. For instance, in a study protocol, exclusion criteria indicate the conditions that prospective subjects SHOULD NOT meet to be eligible for participation in a study
definition editor: Person: Philippe Rocca-Serra
definition source: Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group
imported from: Ontology for Biomedical Investigations

human subject enrollment
type: Class
subclass of: selection
subclass of: Restriction
  on property: has part
  some values from: informed consent process
subclass of: Restriction
  on property: realizes
  some values from: Restriction
    on property: concretizes
    some values from: eligibility criterion
subclass of: Restriction
  on property: has_specified_input
  some values from: Class
    intersection of: population
    intersection of: Restriction
      on property: has part
      some values from: Homo sapiens
subclass of: Restriction
  on property: has_specified_output
  some values from: Class
    intersection of: Class
      intersection of: population
      intersection of: Restriction
        on property: has part
        some values from: Homo sapiens
    intersection of: Restriction
      on property: has role
      some values from: participant under investigation role
editor preferred label: human subject enrollment
example of usage: enlisting familiy members of HIV patients into a study
has curation status: ready for release
definition: A planned process with the objective to obtain a population of human subjects to participate in an investigation by determining eligibility of subjects and obtaining informed consent.
editor note: As with group assignment, should the specified output here be an organism which bears a role
definition editor: Bjoern Peters
definition source: IEDB
curator note: criteria come from plan / clinical trial branch
imported from: Ontology for Biomedical Investigations

collecting specimen from organism
type: Class
subclass of: specimen collection process
subclass of: Restriction
  on property: has_specified_input
  some values from: organism
subclass of: Restriction
  on property: has_specified_output
  some values from: specimen
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: specimen collection objective
editor preferred label: collecting specimen from organism
example of usage: taking a sputum sample from a cancer patient, taking the spleen from a killed mouse, collecting a urine sample from a patient
has curation status: ready for release
definition: a process with the objective to obtain a material entity that was part of an organism for potential future use in an investigation
definition editor: PERSON:Bjoern Peters
definition source: IEDB
imported from: Ontology for Biomedical Investigations

material component separation
type: Class
equivalent class: Restriction
  on property: achieves_planned_objective
  some values from: material separation objective
subclass of: material processing
subclass of: Restriction
  on property: has_specified_input
  some values from: material entity
subclass of: Restriction
  on property: has_specified_output
  some values from: material entity
editor preferred label: material component separation
example of usage: Using a cell sorter to separate a mixture of T cells into two fractions; one with surface receptor CD8 and the other lacking the receptor, or purification
has curation status: ready for release
definition: a material processing in which components of an input material become segregated in space
definition editor: Bjoern Peters
definition source: IEDB
imported from: Ontology for Biomedical Investigations

maintaining cell culture
type: Class
subclass of: material maintenance
subclass of: Restriction
  on property: has_specified_input
  some values from: cultured cell population
subclass of: Restriction
  on property: has_specified_input
  some values from: Class
    union of: culture medium
    union of: cell freezing medium
subclass of: Restriction
  on property: has_specified_output
  some values from: cultured cell population
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: material maintenance objective
editor preferred label: maintaining cell culture
example of usage: When harvesting blood from a human, isolating T cells, and then limited dilution cloning of the cells, the maintaining_cell_culture step comprises all steps after the initial dilution and plating of the cells into culture, e.g. placing the culture into an incubator, changing or adding media, and splitting a cell culture
has curation status: pending final vetting
definition: a protocol application in which cells are kept alive in a defined environment outside of an organism. part of cell_culturing
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived
imported from: Ontology for Biomedical Investigations

establishing cell culture
type: Class
subclass of: material processing
subclass of: Restriction
  on property: has_specified_input
  some values from: cell
subclass of: Restriction
  on property: has_specified_input
  some values from: culture medium
subclass of: Restriction
  on property: has_specified_output
  some values from: cultured cell population
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: material transformation objective
editor preferred label: 'establishing cell culture'
has curation status: metadata complete
definition: a process through which a new type of cell culture or cell line is created, either through the isolation and culture of one or more cells from a fresh source, or the deliberate experimental modification of an existing cell culture (e.g passaging a primary culture to become a secondary culture or line, or the immortalization or stable genetic modification of an existing culture or line).
definition editor: PERSON:Matthew Brush
definition source: PERSON:Matthew Brush
imported from: Ontology for Biomedical Investigations
comment: A 'cell culture' as used here referes to a new lineage of cells in culture deriving from a single biological source.. New cultures are established through the initial isolation and culturing of cells from an organismal source, or through changes in an existing cell culture or line that result in a new culture with unique characteristics. This can occur through the passaging/selection of a primary culture into a secondary culture or line, or experimental modifications of an existing cell culture or line such as an immortalization process or other stable genetic modification. This class covers establishment of cultures of either multicellular organism cells or unicellular organisms.

sequencing assay
type: Class
equivalent class: Class
  intersection of: assay
  intersection of: Class
    intersection of: Restriction
      on property: realizes
      some values from: Class
        intersection of: function
        intersection of: Restriction
    intersection of: Restriction
      on property: has_specified_input
      some values from: Class
        union of: nucleic acid sequencer
        union of: protein sequencer
        union of: DNA sequencer
  intersection of: Class
    intersection of: Restriction
      on property: realizes
      some values from: Class
        intersection of: evaluant role
        intersection of: Restriction
    intersection of: Restriction
      on property: has_specified_input
      some values from: Class
        intersection of: Class
        intersection of: Restriction
  intersection of: Restriction
    on property: has_specified_output
    some values from: sequence data
  intersection of: Restriction
    on property: has_specified_output
    some values from: Restriction
      on property: is about
      some values from: region
subclass of: assay
editor preferred label: sequencing assay
example of usage: The use of the Sanger method of DNA sequencing to determine the order of the nucleotides in a DNA template
has curation status: pending final vetting
definition: An assay the uses chemical or biochemical means to infer the sequence of a biomaterial
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived
imported from: Ontology for Biomedical Investigations

nucleic acid extraction
type: Class
subclass of: extraction
subclass of: Restriction
  on property: has_specified_input
  some values from: Class
    union of: sample from organism
    union of: organism
    union of: cultured cell population
subclass of: Restriction
  on property: has_specified_output
  some values from: nucleic acid
editor preferred label: nucleic acid extraction
example of usage: Phenol / chlorophorm extraction disolvation of protein content folllowed by ethanol precipitation of the nucleic acid fraction over night in the fridge followed by centrifugation to obtain a nucleic acid pellet.
has curation status: pending final vetting
definition: a material separation to recover the nucleic acid fraction of an input material
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived
curator note: requested by Helen Parkinson for MO. Could be defined class
imported from: Ontology for Biomedical Investigations

adaptive immune receptor
type: Class
equivalent class: Class
  union of: B cell receptor complex
  union of: T cell receptor complex
  union of: immunoglobulin complex, circulating
subclass of: protein-containing complex
editor preferred label: adaptive immune receptor
has curation status: metadata incomplete
definition: is a receptor produced by cells of the adaptive immune system with the purpose of binding epitopes.
definition editor: IEDB
definition source: IEDB
imported from: Ontology for Biomedical Investigations

bodily fluid specimen
type: Class
equivalent class: Class
  intersection of: Class
    intersection of: specimen
    intersection of: Restriction
      on property: is_specified_output_of
      some values from: collecting specimen from organism
    intersection of: Restriction
      on property: derives from
      some values from: bodily fluid
subclass of: specimen from organism
editor preferred label: bodily fluid specimen
has curation status: metadata complete
definition: A specimen that is derived from some bodily fluid
definition editor: Christian Stoeckert ORCID:0000-0002-5714-991X
definition editor: Mark A. Miller ORCID:0000-0001-9076-6066
definition source: Christian Stoeckert ORCID:0000-0002-5714-991X
definition source: Mark A. Miller ORCID:0000-0001-9076-6066
imported from: Ontology for Biomedical Investigations

clinical finding
type: Class
subclass of: clinical data item
definition: A representation that is either the output of a clinical history taking or a physical examination or an image finding, or some combination thereof.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2010-07-19T10:18:02Z
imported from: ogms.owl

clinical history
type: Class
subclass of: clinical data item
definition: A series of statements representing health-relevant qualities of a patient and of a patient's family.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2010-07-19T10:18:59Z
imported from: ogms.owl

image finding
type: Class
subclass of: clinical finding
definition: A representation of an image that supports an inference to an assertion about some quality of a patient.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T10:21:10Z
imported from: ogms.owl

laboratory finding
type: Class
subclass of: clinical finding
definition: A representation of a quality of a specimen that is the output of a laboratory test and that can support an inference to an assertion about some quality of the patient.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T10:21:58Z
imported from: ogms.owl

disease
type: Class
subclass of: disposition
definition: A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:21:20Z
imported from: ogms.owl

bodily process
type: Class
subclass of: process
definition editor: Albert Goldfain
curator note: creation date: 2009-06-23T11:53:49Z
imported from: oae.owl
imported from: ogms.owl

pathological bodily process
type: Class
subclass of: bodily process
definition: A bodily process that is clinically abnormal.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:54:29Z
imported from: oae.owl
imported from: ogms.owl

diagnosis
type: Class
subclass of: clinical data item
definition: The representation of a conclusion of a diagnostic process.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T12:42:23Z
imported from: ogms.owl

physical examination finding
type: Class
subclass of: clinical finding
definition: TODO: Define.
definition editor: Albert Goldfain
definition source: http://code.google.com/p/ogms/issues/detail
curator note: creation date: 2009-11-24T04:51:11Z
imported from: ogms.owl

treatment
type: Class
subclass of: planned process
subclass of: health care process
definition: A planned process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate a disorder, the signs and symptoms of a disorder, or a pathological process
definition: A processual entity whose completion is hypothesized (by a healthcare provider) to alleviate the signs and symptoms associated with a disorder
definition editor: Albert Goldfain
definition source: http://code.google.com/p/ogms/issues/detail
curator note: creation date: 2010-03-31T04:51:11Z
imported from: dron.owl
imported from: ogms.owl

health care process
type: Class
subclass of: planned process
definition: A planned process with the objective to improve the health status of a patient that directly involves the treatment, diagnosis, or prevention of disease or injury of a patient
definition editor: Albert Goldfain Sagar Jain
definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6
curator note: creation date: 2011-02-21T09:57:44Z editor date: 2017-04-18
imported from: ogms.owl

health care encounter
type: Class
subclass of: process
definition: A temporally-connected health care process that has as participants an organization or person realizing the health care provider role and a person realizing the patient role. The health care provider role and patient are realized during the health care encounter
definition editor: Albert Goldfain
definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6
curator note: creation date: 2011-02-21T09:57:44Z
imported from: omrse.owl

injury
type: Class
subclass of: material entity
definition: A part of an organism that has undergone a change in structural integrity and has a higher chance of dysfunction or causing dysfunction in another structure.
editor note: At the scale of organism (as opposed to the cellular scale or the population scale), an injury is typically the result of a catastrophic event. Consider the implications of making 'injury' a subtype of 'disorder'.
definition editor: Albert Goldfain
definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/ca0ad373f27774c5
curator note: creation date: 2011-09-20T09:57:44Z
imported from: omrse.owl
imported from: http://purl.obolibrary.org/obo/ogms.owl

diagnostic process
type: Class
subclass of: health care process
definition: A health care process that involves the interpretation of a clinical picture from a given patient (input) and the assertion to the effect that the patient has a disease, disorder, or syndrome of a certain type, or none of these (output).
definition editor: Albert Goldfain
definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/2a7008f311fac766/e7de486c94dfd82e
curator note: creation date: 2011-09-20T09:57:44Z
imported from: ogms.owl

clinical data item
type: Class
subclass of: data item
definition: A data item that is about a patient and is the specified output of a health care process assay or diagnostic process
curator note: creation date: 2018-11-27
imported from: ogms.owl

social security number
type: Class
subclass of: CRID
definition: Social Security Number(SSN) is a Centrally Registered IDentifier that is a nine-digit number issued to U.S. citizens, permanent residents, and temporary (working) residents under section 205(c) of the Social Security Act, codified as 42 U.S.C. § 405(c). The number is issued to an individual by the Social Security Administration, an independent agency of the United States government. Its primary purpose is to track individuals for Social Security purposes.
alternative term: SSN
definition source: http://en.wikipedia.org/wiki/Social_Security_number
imported from: omrse.owl
creator: Cheng Chen(cxchen1@ualr.edu)

human social role
type: Class
subclass of: organism social role
subclass of: Restriction
  on property: characteristic of
  some values from: Homo sapiens
definition: A social role inhering in a human being.
definition editor: Mathias Brochhausen
definition editor: William R. Hogan
imported from: omrse.owl

party to a legal entity
type: Class
subclass of: role in human social processes
subclass of: Class
  intersection of: Restriction
    on property: characteristic of
    some values from: Class
      union of: Homo sapiens
      union of: organization
  intersection of: Restriction
    on property: characteristic of
    all values from: Class
      union of: Homo sapiens
      union of: organization
imported from: omrse.owl

party to a legal proceeding
type: Class
subclass of: party to a legal entity
imported from: omrse.owl

party to a legal agreement
type: Class
subclass of: party to a legal entity
imported from: omrse.owl

party to a marriage contract
type: Class
subclass of: party to a legal agreement
subclass of: Restriction
  on property: characteristic of
  some values from: Homo sapiens
imported from: omrse.owl

party to a power of attorney
type: Class
subclass of: party to a legal entity
imported from: omrse.owl

gender role
type: Class
subclass of: role
subclass of: Restriction
  on property: characteristic of
  some values from: organism
definition: A human social role borne by a human being being realized in behaviour which is considered socially appropriate for individuals of a specific sex in the context of a specific culture.
definition editor: Mathias Brochhausen
definition source: http://en.wikipedia.org/wiki/Gender_role
imported from: omrse.owl

male gender role
type: Class
subclass of: gender role
subclass of: Class
  intersection of: Restriction
    on property: characteristic of
    some values from: organism
  intersection of: Restriction
    on property: characteristic of
    all values from: organism
definition: A gender role borne by a human being that is realized in behaviour which is considered socially appropriate for individuals of the male sex in the context of the culture in question.
definition editor: Mathias Brochhausen
alternative term: male gender
imported from: omrse.owl

female gender role
type: Class
subclass of: gender role
subclass of: Class
  intersection of: Restriction
    on property: characteristic of
    some values from: organism
  intersection of: Restriction
    on property: characteristic of
    all values from: organism
definition: A gender role borne by a human being that is realized in behaviour which is considered socially appropriate for individuals of the female sex in the context of the culture in question.
definition editor: Mathias Brochhausen
alternative term: female gender
imported from: omrse.owl

human health care role
type: Class
subclass of: role in human social processes
subclass of: Restriction
  on property: realized in
  some values from: health care encounter
definition: A role in human social processes that is realized by health care processes such as seeking or providing treatment for disease and injury, diagnosing disease and injury, or undergoing diagnosis.
definition editor: William R. Hogan
alternative term: health care role
imported from: omrse.owl
comment: Mathias Brochhausen

patient role
type: Class
subclass of: human health care role
subclass of: Restriction
  on property: characteristic of
  some values from: organism
definition: A role borne by an organism and that is realized by presenting to a health care provider in a clinical encounter.
definition editor: Amanda Hicks
definition editor: Mathias Brochhausen
alternative term: patient
definition source: CAFE domain expert working group.
imported from: omrse.owl
comment: In order to avoid the presumption of the formal structures and institutions of Western civilization, bearing a patient role does not entail that the organism presents at an official place of business, with an organization formally and legally registered with various gov't entities, with a person endowed by the gov't with certain certifications.

health care provider role
type: Class
subclass of: human health care role
subclass of: Class
  intersection of: Restriction
    on property: characteristic of
    some values from: Class
      union of: Homo sapiens
      union of: organization
  intersection of: Restriction
    on property: characteristic of
    all values from: Class
      union of: Homo sapiens
      union of: organization
definition: A human health care role inhering in an organization or human being that is realized by a process of providing health care services to an organism.
definition editor: Mathias Brochhausen
imported from: omrse.owl
comment: William R. Hogan

physician role
type: Class
subclass of: health care provider role
subclass of: Restriction
  on property: characteristic of
  some values from: Homo sapiens
definition: A health care role borne by a human being and realized by promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury and other physical and mental impairments.
definition editor: Mathias Brochhausen
alternative term: physician
definition source: http://en.wikipedia.org/wiki/Physician
imported from: omrse.owl

nurse role
type: Class
subclass of: health care provider role
subclass of: Restriction
  on property: characteristic of
  some values from: Homo sapiens
definition: A health care role borne by a human being and realized by the care of individuals, families, and communities so they may attain, maintain, or recover optimal health and quality of life.
definition editor: Mathias Brochhausen
alternative term: nurse
definition source: based on: http://en.wikipedia.org/wiki/Nursing
imported from: omrse.owl

health care provider organization role
type: Class
subclass of: organization health care role
subclass of: Restriction
  on property: realized in
  some values from: health care encounter
imported from: omrse.owl
comment: Definition needed, but the idea is that we want to differentiate between provider and payer organizations. Some organizaitons have both roles (e.g., UPMC has a Hospital Division, a Physician Divison, and an Insurance Division).

person health care provider role
type: Class
subclass of: human social role
imported from: omrse.owl

physician practice
type: Class
subclass of: health care provider organization role
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    intersection of: organization
    intersection of: Restriction
      on property: has organization member
      min qualified cardinality: 2
      on class: Restriction
        on property: bearer of
        some values from: physician role
definition: A health care provider organization role that inheres in an organization consisting of two or more physicians.
definition editor: Amanda Hicks
imported from: omrse.owl

integrated delivery network
type: Class
subclass of: health care provider organization role
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    intersection of: organization
    intersection of: Restriction
      on property: has organization member
      all values from: organization
definition: A health care provider organization role that inheres in an organization that is comprised of other organizations.
definition editor: Amanda Hicks
imported from: omrse.owl

collection of organisms
type: Class
subclass of: material entity
definition: An object aggregate of organisms.
imported from: omrse.owl
comment: Any arbitrary collection of organisms. They need not be of the same taxonomic class.

collection of humans
type: Class
subclass of: collection of organisms
imported from: omrse.owl
comment: An object aggregate all of whose components are human beings.

role in human social processes
type: Class
subclass of: role
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    union of: organization
    union of: organism
subclass of: Restriction
  on property: characteristic of
  all values from: Class
    union of: organization
    union of: organism
definition: A role inhering in an entity realized by social interactions in human society.
definition editor: Mathias Brochhausen
imported from: omrse.owl
comment: Previous definition: A role played by an entity in human social processes.

organization social role
type: Class
subclass of: role in human social processes
subclass of: Restriction
  on property: characteristic of
  some values from: organization
definition: A role in human social processes that inheres in an organization.
definition editor: William R. Hogan
imported from: omrse.owl
comment: Defined class that we will ultimately move to an application ontology. We are leaving here for now until we determine which application ontology: it is likely going to be an ontology that does not currently (2012-06-05) exist. Ditto for its current descendants.

organism social role
type: Class
subclass of: role in human social processes
subclass of: Restriction
  on property: characteristic of
  some values from: organism
definition: A role in human social processes that inheres in an organism.
definition editor: William R. Hogan Mathias Brochhausen
imported from: omrse.owl
comment: Defined class that we will ultimately move to an application ontology. We are leaving here for now until we determine which application ontology: it is likely going to be an ontology that does not currently (2012-06-05) exist. Ditto for its current descendants.
comment: Includes animals as well as humans. For example, pet, assistance animal, animal grown for food, work animal, domesticated animal, K-9, etc. Human roles include gender role, party to legal entities, health care provider roles like doctor, nurse, etc.
comment: Previous definition: A role in human social processes played by an organism.

organization health care role
type: Class
subclass of: organization social role
definition: An organization social role that is realized by a health care process.
imported from: omrse.owl
comment: Previous definition: An organization social role played by an organization in health care processes.

human patient role
type: Class
equivalent class: Class
  intersection of: patient role
  intersection of: Restriction
    on property: characteristic of
    some values from: Homo sapiens
definition: A patient role that inheres in a human being.
imported from: omrse.owl

aggregate of organizations
type: Class
equivalent class: Class
  intersection of: Class
    complement of: organization
  intersection of: Restriction
    on property: is-aggregate-of
    all values from: organization
  intersection of: Restriction
    on property: is-aggregate-of
    min qualified cardinality: 2
    on class: organization
subclass of: material entity
definition: An object aggregate that is not itself an organization and whose members are only organizations that have some feature in common
definition editor: William R. Hogan Amanda Hicks
imported from: omrse.owl
comment: It is often convenient to group organizations together that otherwise might not even interact with one another.

legal person role
type: Class
subclass of: role in human social processes
subclass of: Class
  intersection of: Restriction
    on property: characteristic of
    some values from: Class
      union of: Homo sapiens
      union of: collection of humans
  intersection of: Restriction
    on property: characteristic of
    all values from: Class
      union of: Homo sapiens
      union of: collection of humans
definition: A role borne by a human individual or by a collection of humans regarded as possessing rights and duties enforeable at law.
definition editor: Mathias Brochhausen
definition source: Malcolm N. Shaw: International Law. Cambridge University Press, Cambridge, 2008.
imported from: omrse.owl
comment: We are aware of the fact that Wikipedia's definition differs from ours by saying that "Legal personality (...) is the characteristic of a non-living entity regarded by law to have the status of personhood" (http://en.wikipedia.org/wiki/Legal_personality) However, Shaw explicates: "In any legal system, certain entities, whether they be individuals or companies, will be regarded as possessing rights and duties enforceable at law. Thus an individual may prosecute or be prosecuted for assault and a company can sue for breach of contract. They are able to do this because the law recognises them as 'legal persons' possessing the capacity to have and to maintain certain rights, and being subject to perform specific duties. (...) In municipal law individuals, limited companies and public corporations are recognized as each possessing a distinct legal personality, the terms of which are circumscribed by the relevant legislation" (Shaw MN: International Law. Sixth Edition. Cambridge University Press, Cambridge, 2008). We hold that Shaw's position is ontological more prolific since it not only allows to explain how groups of individuals become recognized as unities at law, but also how different individuals can hold different legal personality roles (always against the context of one legal system). The latter will proof useful when dealing with the representing comatous patients or minorsat law in ontologies.

smoker role
type: Class
subclass of: role
subclass of: Restriction
  on property: characteristic of
  some values from: Homo sapiens
definition: A role that inheres in an organism and is realized by habitually smoking tobacco products.
imported from: omrse.owl

material entity role
type: Class
equivalent class: Class
  intersection of: role
  intersection of: Restriction
    on property: characteristic of
    some values from: material entity
subclass of: role
subclass of: Restriction
  on property: characteristic of
  some values from: material entity
subclass of: Restriction
  on property: characteristic of
  all values from: material entity
imported from: obib.owl
imported from: omrse.owl

hospital role
type: Class
subclass of: health care provider organization role
definition: A healthcare provider role that inheres in an organization and is realized by providing inpatient and outpatient care.
definition editor: Mathias Brochhausen
imported from: omrse.owl

school role
type: Class
subclass of: organization social role
definition editor: An organization social role that inheres in an organization and is realized by providing formal education to students.
definition editor: Mathias Brochhausen
imported from: omrse.owl

school organization
type: Class
equivalent class: Class
  intersection of: organization
  intersection of: Restriction
    on property: bearer of
    some values from: school role
subclass of: organization
definition: An organization that is the bearer of a school role.
definition editor: Mathias Brochhausen
imported from: omrse.owl

student role
type: Class
subclass of: human role within an organization
subclass of: Restriction
  on property: concretizes
  some values from: Class
    intersection of: socio-legal generically dependent continuant
    intersection of: Restriction
      on property: is_specified_output_of
      some values from: Class
        intersection of: declaration
        intersection of: Restriction
definition: A human social role that is realized by the process of formal education that the bearer undergoes.
definition editor: Mathias Brochhausen
imported from: omrse.owl

nursery school role
type: Class
subclass of: school role
definition editor: Mathias Brochhausen
imported from: omrse.owl

primary school role
type: Class
subclass of: school role
definition editor: Mathias Brochhausen
imported from: omrse.owl

secondary school role
type: Class
subclass of: school role
definition editor: Mathias Brochhausen
imported from: omrse.owl

pediatric trauma patient role
type: Class
subclass of: human patient role
definition: A trauma patient role that inheres in a homo sapiens who is under the age of 15 years.
definition editor: Amanda Hicks
alternative term: pediatric trauma patient
definition source: The following definition for 'pediatric trauma patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. "A trauma patient who is under the age of 15 years."
imported from: omrse.owl

injured patient role
type: Class
equivalent class: Class
  intersection of: patient role
  intersection of: Restriction
    on property: characteristic of
    some values from: Class
      intersection of: organism
      intersection of: Restriction
        on property: has part
        some values from: injury
subclass of: patient role
definition: A patient role that inheres an organism suffering one or more injuries.
definition editor: Amanda Hicks
alternative term: injured patient
definition source: The following definition for 'injured patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A patient suffering one or more injuries.
imported from: omrse.owl

burn patient role
type: Class
subclass of: injured patient role
definition: A patient role that inheres in an organism suffering a thermal, electrical, chemical or radiation burn.
definition editor: Amanda Hicks
definition editor: The following definition for 'burn patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A patient suffering a thermal, electrical, chemical or radiation burn.
definition editor: burn patient
imported from: omrse.owl

physiatrist role
type: Class
subclass of: physician role
definition: A physician role that is created by training and certification in rehabilitation/physical medicine and that is realized by the provision of or supervising of the provision of rehabilitation or physical therapy to a patient.
definition editor: Amanda Hicks
alternative term: physiatrist
definition source: The following definition for 'physiatrist' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A physician with training and certification in rehabilitation/physical medicine.
imported from: omrse.owl
comment: Definition updated May 5, 2016. Original definitions was, a health care role borne by a human being and realized by training and certification in rehabilitation medicine.

trauma patient role
type: Class
subclass of: patient role
definition: A patient role that inheres in an organism with some non-superficial traumatic injury. The role is realized by admision to a hospital, transfer from one hospital to another for the purpose of trauma care, or has death as a result of the traumatic injury.
definition editor: Amanda Hicks
alternative term: trauma patient
definition source: The following definition for 'trauma patient' was approved by the CAFE team of domain experts (experts in trauma care) May 29, 2015. A patient sustaining an injury who has been admitted to the hospital, transferred from one hospital to another for the purpose of trauma care, or has died as a result of the traumatic injury.
imported from: omrse.owl

residence function
type: Class
subclass of: function
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    intersection of: material entity
    intersection of: Restriction
      on property: has part
      some values from: site
definition: A function that inheres in a material entity and, if realized, is realized by protecting persons and their possessions from weather and by some person or group of persons habitually sleeping in at least one site that is contained by that material entity.
definition editor: Amanda Hicks
imported from: omrse.owl

household
type: Class
equivalent class: Class
  intersection of: Class
    union of: Homo sapiens
    union of: collection of humans
  intersection of: Restriction
    on property: participates in
    some values from: Class
      intersection of: process
      intersection of: Restriction
        on property: realizes
        some values from: residence function
subclass of: material entity
definition: A human or collection of humans that occupies a housing unit by storing their possessions there and habitually sleeping there thereby participating in the realization of its residence function.
definition editor: Amanda Hicks
imported from: omrse.owl

employee role
type: Class
subclass of: human role within an organization
subclass of: Restriction
  on property: concretizes
  some values from: Class
    intersection of: socio-legal generically dependent continuant
    intersection of: Restriction
      on property: is_specified_output_of
      some values from: Class
        intersection of: declaration
        intersection of: Restriction
definition editor: Amanda hicks
alternative term: employee
imported from: omrse.owl

US Census reference person role
type: Class
subclass of: human social role
subclass of: Restriction
  on property: realized in
  some values from: documenting
subclass of: Restriction
  on property: characteristic of
  some values from: Class
    intersection of: Homo sapiens
    intersection of: Restriction
      on property: member of
      some values from: household
definition: A US cenus reference person role is a human social role that inheres in a Homo sapiens who is a member of a household and is realized by other persons in the household being recorded in the US census in relation to that person.
definition editor: Amanda Hicks
definition source: http://www.census.gov/cps/about/cpsdef.html last accessed June 30, 2015
imported from: omrse.owl

socio-legal human social role
type: Class
subclass of: human social role
subclass of: Restriction
  on property: concretizes
  some values from: socio-legal generically dependent continuant
definition editor: A role that concretizes a socio-lega generically dependent continuant
definition editor: Amanda Hicks
imported from: omrse.owl

human role within an organization
type: Class
subclass of: socio-legal human social role
subclass of: Restriction
  on property: concretizes
  some values from: Class
    intersection of: socio-legal generically dependent continuant
    intersection of: Restriction
      on property: is_specified_output_of
      some values from: Class
        intersection of: declaration
        intersection of: Restriction
definition: A socio-legal human social role that concretizes a socio-legally generically dependent continuat that was created by a declaration performed by an organization.
definition editor: Amanda Hicks
imported from: omrse.owl

employer role
type: Class
subclass of: role in human social processes
imported from: omrse.owl

payer role
type: Class
subclass of: role in human social processes
imported from: omrse.owl

party to an insurance policy
type: Class
subclass of: party to a legal agreement
imported from: omrse.owl

US Census unemployed role
type: Class
subclass of: human social role
definition editor: Amanda Hicks
imported from: omrse.owl
comment: A US Census unemployed role is a human social role that inheres in a human who is legally eligible to work, is conferred by the U.S. Census Bureau, and is realized by the bearer not working and either making active efforts to find employment in the four weeks prior to the reference week or waiting to be recalled from temporary layoff.

US physician assistant role
type: Class
subclass of: health care provider role
subclass of: Restriction
  on property: characteristic of
  some values from: Homo sapiens
definition: A human health care provider role that inheres in a human being that is created by state licensing and that is realized by taking patient histories, performing physical exams, diagnosing illnesses, developing treatment plans, ordering lab tests, prescribing medications, counselling and educating patients, suturing wounds, and assisting in surgery under the supervision of a physician or a surgeon.
imported from: omrse.owl

anesthesiologist role
type: Class
subclass of: physician role
definition: A physician role that inheres a human being and, if it is realized, is realized either by administering medication for the temporary general or local suppression of sensory or motor nerve function during some health care encounter or by making decisions independently of a supervising physician regarding the adminstration of such medication.
imported from: omrse.owl

surgeon role
type: Class
subclass of: physician role
subclass of: Restriction
  on property: realized in
  some values from: surgery
imported from: omrse.owl

neurosurgereon role
type: Class
subclass of: surgeon role
definition: A surgeon role realized by its bearer using performing neurosurgery.
imported from: omrse.owl

heavy smoker role
type: Class
subclass of: smoker role
definition: A role that inheres in an organism and is realized by habitually smoking 10 or more tobacco cigerettes a day or the equivalent in other tobacco products.
imported from: omrse.owl

light smoker role
type: Class
subclass of: smoker role
definition: A role that inheres in an organism and is realized by habitually smoking 1>10 tobacco cigerettes a day or the equivalent in other tobacco products.
imported from: omrse.owl

employment data
type: Class
subclass of: socio-economic data
imported from: omrse.owl

income data
type: Class
subclass of: socio-economic data
imported from: omrse.owl

government assistance health care plan data
type: Class
subclass of: socio-economic data
imported from: omrse.owl

health care plan data
type: Class
subclass of: socio-economic data
imported from: omrse.owl

government assistance income data
type: Class
subclass of: socio-economic data
imported from: omrse.owl

WIC data
type: Class
subclass of: socio-economic data
imported from: omrse.owl

socio-economic data
type: Class
subclass of: data item
imported from: omrse.owl

precision medicine process
type: Class
equivalent class: Restriction
  on property: achieves_planned_objective
  some values from: precision medicine objective
subclass of: planned process
definition: A planned process that achieves the planned objective of precision medicine objective. Specifically, it is a medical process that includes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to the individual patient.
definition editor: Oliver He, Jie Zheng
definition source: https://en.wikipedia.org/wiki/Precision_medicine

precision medicine investigation
type: Class
subclass of: investigation
subclass of: Restriction
  on property: achieves_planned_objective
  some values from: precision medicine objective
definition: An investigation that is targeted for precision medicine
definition source: https://en.wikipedia.org/wiki/Precision_medicine

household size
type: Class
subclass of: socio-economic data
definition: the number of people living together supported jointly by an household income
definition source: https://www.healthcare.gov/income-and-household-information/household-size/
comment: We may use IRS's definition: https://www.healthcare.gov/income-and-household-information/household-size/

more than 5.5 pounds (2500 grams) birth weight
type: Class
subclass of: birth weight

less than 5.5 pounds (2500 grams) birth weight
type: Class
subclass of: birth weight

unknown birth weight
type: Class
subclass of: birth weight

birth weight declined to answer
type: Class
subclass of: birth weight

individual plan insurance (paid by the member)
type: Class
subclass of: health insurance plan

group plan insurance through employee union
type: Class
subclass of: health insurance plan

USA government health plan insurance
type: Class
subclass of: health insurance plan

no insurance status
type: Class
subclass of: health insurance plan

body temperature measured orally
type: Class
subclass of: body temperature

body temprature by ear (tempanic, aural)
type: Class
subclass of: body temperature

body temprature by forhead
type: Class
subclass of: body temperature

arterial line body temperature
type: Class
subclass of: body temperature

body temprature by other measurement
type: Class
subclass of: body temperature
comment: What is other?

higher than 7th but less than 12th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates a grade of higher than 7th but lower than 12 as the highest level of educational achievement.

direct serum bilirubin level
type: Class
subclass of: blood chemistry measurement

precision medicine objective
type: Class
subclass of: objective specification

less than 8th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates the 7th grade complete or less as the highest level of educational achievement.

high school completion, GED or equivalent
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is a high school completion, GED, or equivalent

answer to question
type: Class
subclass of: information content entity
definition: An information content entity that is the answer to a specific question
definition editor: Fred Dowd, Oliver He

yes answer to question
type: Class
subclass of: answer to question
definition: An answer to question where the answer is Yes.
definition editor: Oliver He, Fred Dowd

no answer to question
type: Class
subclass of: answer to question
definition: An answer to question where the answer is No.
definition editor: Fred Dowd, Oliver He

unknown answer to question
type: Class
subclass of: answer to question
definition: An answer to question that indicates the response to the specified question is unknown.
definition editor: Fred Dowd, Oliver He, Edison Ong
alternative term: do not know answer to question

do not know due to data unavailable answer to question
type: Class
subclass of: unknown answer to question
definition: A do not know answer to question that is answered due to data unavailable
definition editor: Fred Dowd, Oliver He

declined to answer to question
type: Class
subclass of: answer to question
definition: An answer to question where one declines to answer the specified question.
definition editor: Fred Dowd, Oliver He
alternative term: decline to answer
alternative term: declined to provide
alternative term: refuse to answer
alternative term: refused to answer

other answer to question
type: Class
subclass of: answer to question
definition: An answer to question that is not enumerated in the list and then may be entered with free text in a separate text box
definition editor: Oliver He, Fred Dowd

none answer to question
type: Class
subclass of: answer to question
definition: An answer to question that is not listed in the whole list of response options
definition editor: Oliver He, Fred Dowd

textual question
type: Class
subclass of: textual entity
definition: A textual entity that is a question presented in text
definition editor: Fred Dowd, Oliver He

medical history form
type: Class
subclass of: enrollment CRF

eligibility assessment form
type: Class
subclass of: screening and patient tracking CRF
definition: A form with questions that is used to assess a person's eligibility to participate in a specific study (e.g., kidney precision medicine project).
definition editor: Fred Down, Oliver He

demographic information form
type: Class
subclass of: enrollment CRF
definition: A form with questions that includes statistical data related to particular groups within a population where a person belongs to
definition editor: Fred Dowd, Oliver He
alternative term: demographics form
definition source: https://www.investopedia.com/terms/d/demographics.asp

physical measurement form
type: Class
subclass of: enrollment CRF

question with enumerated responses
type: Class
subclass of: textual question
definition: A textual question that includes a list of enumerated answers
definition editor: Fred Dowd, Oliver He

question with yes and no responses
type: Class
subclass of: question with enumerated responses where only one answer chosen
definition: A question that has two primary and definitive answers: Yes and No, and there may be other given options like Don't know or Decline to answer.
definition editor: Fred Dowd, Oliver He

question with enumerated responses where only one answer chosen
type: Class
subclass of: question with enumerated responses
definition: A question with enumerated responses where one can only choose one answer.
definition editor: Fred Dowd, Oliver He

question with enumerated responses where multiple answers may be chosen
type: Class
subclass of: question with enumerated responses
definition: A question with enumerated responses where one can choose multiple answers.
definition editor: Fred Dowd, Oliver He

case report form
type: Class
subclass of: document
definition: A case report form (or CRF) is a paper or electronic questionnaire specifically used in clinical trial research
definition editor: Oliver He, Edison Ong, Fred Dowd, Hong Yu
alternative term: CRF
definition source: https://en.wikipedia.org/wiki/Case_report_form
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170533/

laboratory result form
type: Class
subclass of: case report form
definition editor: Fred Down, Oliver He

new patient form
type: Class
subclass of: screening and patient tracking CRF
definition editor: Fred Down, Oliver He

biopsy procedure form
type: Class
subclass of: biopsy-related CRF
definition editor: Fred Down, Oliver He

kidney biopsy procedure form
type: Class
subclass of: biopsy procedure form

consent form
type: Class
subclass of: screening and patient tracking CRF
definition editor: Fred Down, Oliver He

paper form
type: Class
subclass of: case report form
definition editor: Fred Down, Oliver He

paper form with signature required
type: Class
subclass of: paper form
example of usage: Medical records release form is usually required to be a paper form that should be signed by the patient who agrees to have his/her medical records released.
definition editor: Fred Dowd, Oliver He

sanitation
type: Class
subclass of: process
definition: A public health process that involves clean drinking water and adequate treatment and disposal of human and animal excreta and sewage.
definition source: https://en.wikipedia.org/wiki/Sanitation

contact information form
type: Class
subclass of: screening and patient tracking CRF
definition: A form that includes the information of contact for a person
definition editor: Edison Ong, Oliver He

biosample collection form
type: Class
subclass of: case report form

clinic reception form
type: Class
subclass of: case report form

medications form
type: Class
subclass of: screening and patient tracking CRF

participant study status form
type: Class
subclass of: screening and patient tracking CRF

hospitalization form
type: Class
subclass of: case report form

personal history form
type: Class
subclass of: enrollment CRF

AKI hospitalization form
type: Class
subclass of: hospitalization form

CKD hospitalization form
type: Class
subclass of: hospitalization form

participant reported outcome measures form
type: Class
subclass of: enrollment CRF
definition editor: Fred Dowd, Oliver He
comment: This should be a paper form

health literacy questionnaire form
type: Class
subclass of: enrollment CRF

biopsy safety checklist form
type: Class
subclass of: biopsy-related CRF

post biopsy form
type: Class
subclass of: biopsy-related CRF

tissue tracking form
type: Class
subclass of: biopsy-related CRF
subclass of: Restriction
  on property: is about
  some values from: tissue tracking
definition: A clinical report form that covers the information about the tracking of biopsied tissue

pathology images upload form
type: Class
subclass of: pathology CRF

diagnostic core .jpg images QC form
type: Class
subclass of: pathology CRF
alternative term: Dx core - .jpg images QC form

diagnostic core - disease categories form
type: Class
subclass of: pathology CRF
alternative term: Dx core - disease categories form

central path quality metrics assessment Dx core form
type: Class
subclass of: pathology CRF

central path quality metrics assessment interrogation core form
type: Class
subclass of: pathology CRF

post-biopsy patient experience survey form
type: Class
subclass of: biopsy-related CRF

adverse event entry form
type: Class
subclass of: screening and patient tracking CRF

month of year
type: Class
subclass of: one-dimensional temporal region

January
type: Class
subclass of: month of year
definition: The first month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

February
type: Class
subclass of: month of year
definition: The second month of the year in the Gregorian calendar.
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

March
type: Class
subclass of: month of year
definition: The third month of the year in the Gregorian calendar.
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

April
type: Class
subclass of: month of year
definition: The4th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

May
type: Class
subclass of: month of year
definition: The 5th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

June
type: Class
subclass of: month of year
definition: The 6th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

July
type: Class
subclass of: month of year
definition: The 7th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

August
type: Class
subclass of: month of year
definition: The 8th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

September
type: Class
subclass of: month of year
definition: The 9th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

October
type: Class
subclass of: month of year
definition: The 10th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

November
type: Class
subclass of: month of year
definition: The 11th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

December
type: Class
subclass of: month of year
definition: The 12th month of the year in the Gregorian calendar
definition source: https://en.wikipedia.org/wiki/Gregorian_calendar

day of week
type: Class
subclass of: one-dimensional temporal region
definition: A day of a calendar week that includes covers 24 hours each day.
definition source: https://en.wikipedia.org/wiki/Week

Monday
type: Class
subclass of: day of week
definition: The first day of the week.
definition source: https://en.wikipedia.org/wiki/Week

Tuesday
type: Class
subclass of: day of week
definition: The second day of the week.
definition source: https://en.wikipedia.org/wiki/Week

Wednesday
type: Class
subclass of: day of week
definition: The third day of the week.
definition source: https://en.wikipedia.org/wiki/Week

Thursday
type: Class
subclass of: day of week
definition: The fourth day of the week.
definition source: https://en.wikipedia.org/wiki/Week

Friday
type: Class
subclass of: day of week
definition: The fifth day of the week.
definition source: https://en.wikipedia.org/wiki/Week

Saturday
type: Class
subclass of: day of week
definition: The 6th day of the week.
definition source: https://en.wikipedia.org/wiki/Week

Sunday
type: Class
subclass of: day of week
definition: The 7th day of the week.
definition source: https://en.wikipedia.org/wiki/Week

day of birth
type: Class
subclass of: birth-related time
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: A day when an organism (e.g., a human) is born.
definition editor: Oliver He, Long Tran
alternative term: birth date
definition source: https://www.ohdsi.org/web/wiki/doku.php

birthday
type: Class
subclass of: birth-related time
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: the anniversary of the birth of a person
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Birthday
comment: There is a difference between birthday and birthdate: The former, such as February 29, occurs each year, while the latter is the exact date a person was born (e.g., January 15, 2001).

personal information
type: Class
equivalent class: Class
  intersection of: information content entity
  intersection of: Restriction
    on property: is about
    some values from: Homo sapiens
subclass of: information content entity
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: information associated with an individual
definition editor: Oliver He
definition source: https://www.oic.qld.gov.au/guidelines/for-government/access-and-amendment/introduction-to-the-acts/what-is-personal-information

person name
type: Class
subclass of: textual entity
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: A name of a person, which can have different types
alternative term: human name
definition source: https://en.wikipedia.org/wiki/Personal_name

person first name
type: Class
subclass of: person name
alternative term: Christian name
alternative term: forename
alternative term: given name
definition source: https://en.wikipedia.org/wiki/Personal_name

person last name
type: Class
subclass of: person name
alternative term: family name
alternative term: surname
definition source: https://en.wikipedia.org/wiki/Personal_name

person middle name
type: Class
subclass of: person name
definition source: https://en.wikipedia.org/wiki/Personal_name

person full name
type: Class
subclass of: person name
definition: 患者本人在公安户籍管理部门正式登记注册的姓氏和名称 @zh
definition editor: Suyuan Peng, Hong Yu, Yongqun He
definition source: https://en.wikipedia.org/wiki/Personal_name
definition source: 《电子病历基本数据集 第10部分：住院病案首页》WS 445.10-2014 @zh

person legal name
type: Class
subclass of: person name
definition: A person name that identifies a person for legal, administrative and other official purposes
definition editor: Oliver He
alternative term: legal name
definition source: https://en.wikipedia.org/wiki/Legal_name

birth name
type: Class
subclass of: person name
definition: A person name that is given at birth

person login username
type: Class
subclass of: person name
definition: A person name that is used for a person to access a computer system.

maiden name
type: Class
subclass of: person last name
definition: A woman's surname before marriage
definition editor: Edison Ong, Oliver He
definition source: https://en.wikipedia.org/wiki/Maiden_and_married_names

pseudonym
type: Class
subclass of: person name
definition: A person name that is fictitious and generated for a person to perform a particular social role.

marital status
type: Class
subclass of: status
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: Personal information that indicates a person's status in marriage
definition source: https://en.wikipedia.org/wiki/Marital_status

married marital status
type: Class
subclass of: marital status
alternative term: civil status
alternative term: married
definition source: https://en.wikipedia.org/wiki/Marital_status

single marrital status
type: Class
subclass of: not married marital status

divorced marrital status
type: Class
subclass of: not married marital status

widowed marrital status
type: Class
subclass of: not married marital status
definition: A marital status that indicates no marriage status due to the death of his/her spouse and no remarriage.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Widow

legally separated marital status
type: Class
subclass of: married marital status

not married marital status
type: Class
subclass of: marital status

education level
type: Class
subclass of: socioeconomic status
definition: An education level that indicates that the highest level of education achievement for a person.
definition editor: Oliver He, Edison Ong
alternative term: highest degree of education completed
alternative term: highest degree of education received
alternative term: highest degree of school completed

telephone number
type: Class
subclass of: centrally registered identifier symbol
subclass of: Restriction
  on property: is about
  some values from: contact person
definition: A telephone number is a sequence of digits assigned to a fixed-line telephone subscriber station connected to a telephone line or to a wireless electronic telephony device, such as a radio telephone or a mobile telephone, or to other devices for data transmission via the public switched telephone network (PSTN) or other public and private networks.
definition editor: Oliver He
alternative term: phone number
definition source: https://en.wikipedia.org/wiki/Telephone_number

home telephone number
type: Class
subclass of: telephone number
definition: A telephone number used for a phone at home
definition editor: Oliver He
alternative term: home phone number

work telephone number
type: Class
subclass of: telephone number
definition: A telephone number used for a phone at work
definition editor: Oliver He
alternative term: work phone number

cellular telephone number
type: Class
subclass of: telephone number
definition editor: A telephone number that is used in a cellular device
definition editor: Oliver He
alternative term: cell phone number
alternative term: cellular phone number

unemployment status
type: Class
subclass of: employment status
definition: The status of actively looking for employment, but not being currently employed.
alternative term: joblessness
alternative term: unemployment
definition source: https://en.wikipedia.org/wiki/Unemployment
term mapping to NCIT ID: NCIT_C75563
term mapping to UMLS CUI: C0041674

home postal address
type: Class
subclass of: postal address

work postal address
type: Class
subclass of: postal address

postal code
type: Class
subclass of: centrally registered identifier symbol
subclass of: Restriction
  on property: part of
  some values from: postal address
definition: A series of letters or digits or both, sometimes including spaces or punctuation, included in a postal address for the purpose of sorting mail.
definition editor: Oliver He
alternative term: post code
alternative term: postcode
definition source: https://en.wikipedia.org/wiki/Postal_code

ZIP code
type: Class
subclass of: postal code
definition: A ZIP Code is a postal code used by the United States Postal Service (USPS). The term ZIP is an acronym for Zone Improvement Plan.
definition editor: Oliver He, Fred Dowd
definition source: https://en.wikipedia.org/wiki/ZIP_Code

socioeconomic status
type: Class
subclass of: status
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: The personal information that indicates an individual's or his/her family's economic and social position in relation to others, based on income, education, and occupation.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Socioeconomic_status

employment status
type: Class
subclass of: socioeconomic status
definition: An socioeconomic status that indicates the status of being employed in an occupation to perform an activity or service for wage or salary. It is the status of a worker in a company or institute on the basis of the contract of work or duration of work done.
definition editor: Oliver He
definition source: https://definitions.uslegal.com/e/employment-status/
definition source: https://en.wikipedia.org/wiki/Employment
term mapping to NCIT ID: NCIT_C25172
term mapping to UMLS CUI: C0014003

full time employment status
type: Class
subclass of: employment status
definition: A state of employment in which a person works for a minimum number of hours defined as full-time by their employer.
definition source: https://en.wikipedia.org/wiki/Full-time
term mapping to NCIT ID: NCIT_C52658
term mapping to UMLS CUI: C0682295

part time employment status
type: Class
subclass of: employment status
definition: a status of employment that carries fewer hours per week than a full-time job.
alternative term: part-time contract
alternative term: part-time employment
definition source: https://en.wikipedia.org/wiki/Part-time_contract
term mapping to NCIT ID: NCIT_C75562
term mapping to UMLS CUI: C0682294

hourly employment status
type: Class
subclass of: employment status
definition: an employment status where the work is arranged and paid on a hourly basis.
term mapping to NCIT ID: NCIT_C116002
term mapping to UMLS CUI: C0681101

self-employment status
type: Class
subclass of: employment status
definition: The state of working for oneself rather than an employer.
definition source: https://en.wikipedia.org/wiki/Self-employment
term mapping to NCIT ID: NCIT_C116000
term mapping to UMLS CUI: C0425092

temporary employment status
type: Class
subclass of: employment status
definition: An employment situation where the working arrangement is limited to a certain period of time based on the needs of the employing organization.
alternative term: odd job
alternative term: temporary work
definition source: https://en.wikipedia.org/wiki/Temporary_work

Master's degree education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is a Master's degree.
alternative term: M.S. degree education level
alternative term: MS degree completed

academic Doctorate degree education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is an academic Doctorate degree
alternative term: Ph.D. degree education level
alternative term: PhD degree completed

no formal school education level
type: Class
subclass of: education level
definition: An education level that indicates that a person does not have formal school education.

high school education level
type: Class
subclass of: high school completion, GED or equivalent
definition: An education level that indicates that the highest level of education achievement for a person is a high school completion.

Bachelor's degree education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is a Bachelor's degree
alternative term: B.S. degree completed
alternative term: B.S. degree education level
alternative term: Bacholar's degree completed

professional doctorate degree education level
type: Class
subclass of: education level
definition: An education level that indicates that a person has obtained a degree allowing them to practice a profession, such as law, medicine, music, or ministry.
term mapping to NCIT ID: NCIT_C70558
term mapping to UMLS CUI: C2347690

M.D. completion education level
type: Class
subclass of: professional doctorate degree education level

Pharmacy complete education level
type: Class
subclass of: professional doctorate degree education level

kindergarten completion education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is kindergarten completion.

preschool completion education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is preschool.

GED education level
type: Class
subclass of: high school completion, GED or equivalent
definition: An education level that indicates that the highest level of education achievement for a person is the pass of a General Education Development (GED) tests. The GED tests are a group of four subject tests which, when passed, provide certification that the test taker has United States or Canadian high school-level academic skills.
alternative term: general equivalency diploma completion
definition source: https://en.wikipedia.org/wiki/General_Educational_Development

1st Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 1st Grade elementary school completion.

2nd Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the second Grade elementary school completion.

3rd Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the third Grade elementary school completion.

4th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 4th Grade elementary school completion.

5th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 5th Grade elementary school completion.

6th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 6th Grade elementary school completion.

7th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 7th Grade elementary school completion.

8th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 8th Grade elementary school completion.

9th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 9th Grade elementary school completion.

10th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 10th Grade elementary school completion.

11th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 11th Grade elementary school completion.

12th Grade education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is the 12th Grade elementary school completion.

associate academic degree education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is a degree from a 2 year college program.
term mapping to NCIT ID: NCIT_C19752
term mapping to UMLS CUI: C1879750

vocational program completion education level
type: Class
subclass of: education level
definition: An education level that indicates that the highest level of education achievement for a person is a degree from an occupational, technical, or vocational program
term mapping to NCIT ID: NCIT_C67141
term mapping to UMLS CUI: C1883542

health insurance plan
type: Class
subclass of: plan specification
subclass of: personal information
definition: The code in the specific coding system for the payment method of the expenses incurred in a single hospitalization of the patient
definition: 患者单次住院诊疗所发生费用的支付方式的特定编码体系中的代码 @zh
definition editor: Suyuan Peng, Hong Yu, Yongqun He @zh
definition source: 《电子病历基本数据集 第10部分：住院病案首页》WS 445.10-2014 @zh
term mapping to NCIT ID: NCIT_C16745
term mapping to UMLS CUI: C0021672
alternative term in Chinese: 医疗付费方式 @zh

Medicaid
type: Class
subclass of: USA government health plan insurance
definition: A joint federal and state program that helps with medical costs for some people with limited income and resources.
definition source: https://en.wikipedia.org/wiki/Medicaid

Medicare
type: Class
subclass of: USA government health plan insurance
definition: Medicare is a national health insurance program in the United States, begun in 1966 under the Social Security Administration and now administered by the Centers for Medicare and Medicaid Services (CMS).
definition source: https://en.wikipedia.org/wiki/Medicare_(United_States)

private health insurance plan
type: Class
subclass of: health insurance plan

worker compensation insurance plan
type: Class
subclass of: health insurance plan

body weight
type: Class
subclass of: weight

birth weight
type: Class
subclass of: body weight
definition: A body weight that is obtained immediately after birth
definition editor: Oliver He, Edison Ong
term mapping to NCIT ID: NCIT_C76325

emergency contact phone number
type: Class
subclass of: telephone number

care provider
type: Class
subclass of: Homo sapiens

primary care provider
type: Class
subclass of: care provider
alternative term: 1st care provider

centrally registered study identifier symbol
type: Class
subclass of: centrally registered identifier symbol
definition: a centrally registered identifier symobol that refers to a specific study
definition editor: Oliver He, Edison Ong
alternative term: study ID

secondary care provider
type: Class
subclass of: care provider
alternative term: 2nd care provider

tertiary care provider
type: Class
subclass of: care provider
alternative term: 3rd care provider

2nd email address
type: Class
subclass of: email address
definition: An email address that is used secondary after the de fault first email address.

age question
type: Class
equivalent class: Class
  intersection of: textual question
  intersection of: Restriction
    on property: is about
    some values from: age
subclass of: textual question
subclass of: Restriction
  on property: is about
  some values from: age
definition: A textual question about age
definition editor: Fred Dowd, Oliver he

Whether age less than 18 years old
type: Class
subclass of: age question
subclass of: Restriction
  on property: is about
  some values from: age less than 18 years
subclass of: Restriction
  on property: has answer
  some values from: Class
    union of: yes answer to question
    union of: no answer to question
    union of: unknown answer to question
definition: A textual question that asks whether a person's age is less than 18 years old
definition editor: Fred Dowd, Oliver He

KPMP eligibility assessment form
type: Class
subclass of: eligibility assessment form
subclass of: Restriction
  on property: has exclusion question
  some values from: Whether age less than 18 years old
subclass of: Restriction
  on property: has exclusion question
  some values from: Whether BMI greater than 40 kg per m2
subclass of: Restriction
  on property: has exclusion question
  some values from: Whether pregnant
subclass of: Restriction
  on property: has exclusion question
  some values from: Whether transplant recipient
subclass of: Restriction
  on property: has inclusion question
  some values from: Whether diabetic kidney disease (DKD)
subclass of: Restriction
  on property: has inclusion question
  some values from: Whether hypertensive CKD (H-CKD)
subclass of: Restriction
  on property: has inclusion question
  some values from: Whether diabetic nephropathy resisters percutaneous biopsy
subclass of: Restriction
  on property: has inclusion question
  some values from: Whether AKI percutaneous biopsy
subclass of: Restriction
  on property: has inclusion question
  some values from: Whether AKI open biopsy
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition: An eligibility assessment form that is designed and used by the Kidney Precision Medicine Project (KPMP; http://kpmp.org) organization.
definition editor: Oliver He, Edison Ong, Fred Dowd

BMI question
type: Class
subclass of: textual question

Whether BMI greater than 40 kg per m2
type: Class
subclass of: BMI question
subclass of: Restriction
  on property: is about
  some values from: Body Mass Index 19 to Less Than 21
alternative term: Whether BMI greater than 40 kg/m2

BMI greater than 40 kg per m2
type: Class
subclass of: Body Mass Index Finding

question about blood transfusion
type: Class
subclass of: textual question

Whether unwilling to receive blood transfusion
type: Class
subclass of: question about blood transfusion
subclass of: Restriction
  on property: is about
  some values from: unwilling to receive a blood transfusion
definition editor: Edison Ong, Oliver He

pregnancy question
type: Class
subclass of: textual question

Whether pregnant
type: Class
subclass of: pregnancy question
definition: A pregnancy question that asks whether a person is pregnant at the moment of being questioned
definition editor: Fred Dowd, Oliver He
alternative term: Whether pregnancy occurs now

transplant question
type: Class
subclass of: textual question

Whether transplant recipient
type: Class
subclass of: transplant question
definition: A transplant question that asks whether a person has received some transplant (includes solid transplant and bone marrow). Example transplants are kidney transplant and heart transplant.
definition editor: Fred Dowd, Oliver He

Whether kidney transplant recipient
type: Class
subclass of: Whether transplant recipient
definition: A transplant question that asks whether a person has received a kidney transplant.
definition editor: Fred Dowd, Oliver He

KPMP clinical report form
type: Class
equivalent class: Class
  intersection of: case report form
  intersection of: Restriction
    on property: form generated by
    has value: KPMP organization
subclass of: case report form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP biopsy procedure form
type: Class
subclass of: kidney biopsy procedure form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition: A biopsy procedure form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization.
definition editor: Oliver He, Fred Dowd, Edison Ong

KPMP biosample collection form
type: Class
subclass of: biosample collection form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition: A biosample collection form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization.

KPMP adverse event entry form
type: Class
subclass of: adverse event entry form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition: An adverse event entry form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization.

KPMP biopsy safety checklist form
type: Class
subclass of: biopsy safety checklist form
subclass of: Restriction
  on property: has question
  some values from: Whether diabetic kidney disease (DKD)
subclass of: Restriction
  on property: has question
  some values from: Whether hypertensive CKD (H-CKD)
subclass of: Restriction
  on property: has question
  some values from: Whether diabetic nephropathy resisters percutaneous biopsy
subclass of: Restriction
  on property: has question
  some values from: Whether AKI percutaneous biopsy
subclass of: Restriction
  on property: has question
  some values from: Whether AKI open biopsy
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition: A biopsy safety checklist form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization.
definition editor: Oliver He, Fred Dowd, Edison Ong

KPMP clinic reception form
type: Class
subclass of: clinic reception form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition: A clinic reception form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization.
definition editor: Oliver He, Edison Ong, Fred Dowd

KPMP contact information form
type: Class
subclass of: contact information form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition: A contact information form that is designed and used by the Kidney Precision Medicine Project (KPMP) organization.

KPMP demographic information form
type: Class
subclass of: demographic information form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP health literacy questionnaire form
type: Class
subclass of: health literacy questionnaire form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

eligibility question
type: Class
subclass of: textual question
subclass of: Restriction
  on property: is about
  some values from: eligibility criterion
definition: A textual question that is about eligibility of a person to participate in a project.
definition editor: Edison Ong, Oliver He

KPMP AKI hospitalization form
type: Class
subclass of: AKI hospitalization form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP CKD hospitalization form
type: Class
subclass of: CKD hospitalization form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP laboratory result form
type: Class
subclass of: laboratory result form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP medical history form
type: Class
subclass of: medical history form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP consent form
type: Class
subclass of: consent form
subclass of: Restriction
  on property: has question
  some values from: Whether patient eligible to consent
subclass of: Restriction
  on property: has question
  some values from: Whether patient signed HIPPA release form
subclass of: Restriction
  on property: has question
  some values from: When HIPAA release form signed
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization
definition editor: Fred Dowd, Oliver He
comment: This form is the end of a successful screening process

KPMP medications form
type: Class
subclass of: medications form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP new patient form
type: Class
subclass of: new patient form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP participant reported outcome measures form
type: Class
subclass of: participant reported outcome measures form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP participant study status form
type: Class
subclass of: participant study status form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP pathology images upload form
type: Class
subclass of: pathology images upload form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP patient experience survey form
type: Class
subclass of: post-biopsy patient experience survey form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP personal history form
type: Class
subclass of: personal history form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP physical measurement form
type: Class
subclass of: physical measurement form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP post biopsy form
type: Class
subclass of: post biopsy form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP tissue tracking form
type: Class
subclass of: tissue tracking form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP Dx core - .jpg images QC form
type: Class
subclass of: diagnostic core .jpg images QC form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP Dx core - disease categories form
type: Class
subclass of: diagnostic core - disease categories form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP central path quality metrics assessment Dx core form
type: Class
subclass of: central path quality metrics assessment Dx core form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

KPMP central path quality metrics assessment interrogation core form
type: Class
subclass of: central path quality metrics assessment interrogation core form
subclass of: Restriction
  on property: form generated by
  has value: KPMP organization

last four digits of social security number
type: Class
subclass of: CRID
subclass of: Restriction
  on property: part of
  some values from: social security number
definition: The last four digits of a social security number, which is often asked in a survey form.
definition editor: Oliver He
alternative term: last 4 digits of SSN
definition source: http://en.wikipedia.org/wiki/Social_Security_number

self
type: Class
subclass of: Homo sapiens
example of usage: A question in a survey form may ask whether a provided email address belongs to self
definition: The self is an individual person as the object of his or her own reflective consciousness.
definition editor: Oliver He
alternative term: human self
definition source: https://en.wikipedia.org/wiki/Self

email question
type: Class
subclass of: textual question
subclass of: Restriction
  on property: is about
  some values from: email address
definition: A textual question about age
definition editor: Fred Dowd, Oliver he

What email address
type: Class
subclass of: email question
definition: An email question that asks the exact email address

Whether self owns email address
type: Class
subclass of: Who owns email address
definition: An email question that asks whether the email address provided belongs to the person being surveyed.

Who owns email address
type: Class
subclass of: email question
definition: An email question that asks whether the email address provided belongs to the person being surveyed.

What is your birthday
type: Class
subclass of: textual question
subclass of: Restriction
  on property: is about
  some values from: birthday
definition: A textual question that asks the birthday of the person being surveyed

contact name
type: Class
subclass of: textual entity
definition: The textual name of the contact person or organization

emergency contact name
type: Class
subclass of: contact name
definition: The textual name of the contact person or organization that will be contacted during emergency

Who owns the 2nd email address
type: Class
subclass of: Who owns email address

Who owns the 3rd email address
type: Class
subclass of: Who owns email address

physician information
type: Class
subclass of: information content entity

physician specialty information
type: Class
subclass of: physician information

health care
type: Class
subclass of: process
definition: Health care or healthcare is the maintenance or improvement of health via the prevention, diagnosis, and treatment of disease, illness, injury, and other physical and mental impairments in human beings.
definition editor: Oliver He
alternative term: healthcare
definition source: https://en.wikipedia.org/wiki/Health_care

patient care
type: Class
subclass of: health care
definition: A health care rendered for the benefit of a patient.
term mapping to NCIT ID: C0017313
term mapping to NCIT ID: C15239

primary care
type: Class
subclass of: patient care
definition: Primary care refers to the work of health professionals who act as a first point of consultation for all patients within the health care system
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Health_care#Primary_care
term mapping to NCIT ID: C94340
term mapping to UMLS CUI: C0033137

secondary care
type: Class
subclass of: patient care
definition: Secondary care includes acute care: necessary treatment for a short period of time for a brief but serious illness, injury, or other health condition. This care is often found in a hospital emergency department. Secondary care also includes skilled attendance during childbirth, intensive care, and medical imaging services.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Health_care#Secondary_care

tertiary care
type: Class
subclass of: patient care
definition: Tertiary care is specialized consultative health care, usually for inpatients and on referral from a primary or secondary health professional, in a facility that has personnel and facilities for advanced medical investigation and treatment, such as a tertiary referral hospital.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Health_care#Tertiary_care

quaternary care
type: Class
subclass of: patient care
definition: The term quaternary care is sometimes used as an extension of tertiary care in reference to advanced levels of medicine which are highly specialized and not widely accessed.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Health_care#Quaternary_care

hospital care
type: Class
subclass of: patient care
definition: A patient care that is provided in hospital.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Health_care#Secondary_care
comment: It is sometimes the synonym of secondary care. However, many secondary care providers, such as psychiatrists, clinical psychologists, occupational therapists, most dental specialties or physiotherapists do not necessarily work in hospitals. Some primary care services are delivered within hospitals. Depending on the organization and policies of the national health system, patients may be required to see a primary care provider for a referral before they can access secondary care.

nephrology care
type: Class
subclass of: secondary care

endocrinology care
type: Class
subclass of: secondary care

physician question
type: Class
subclass of: textual question

What physician's specialty
type: Class
subclass of: physician question
alternative term: What is the physician's specialty?

hospital question
type: Class
subclass of: textual question

what name of hospital
type: Class
subclass of: hospital question
alternative term: What is name of clinic or hospital

address question
type: Class
subclass of: textual question
alternative term: postal address question

What street name
type: Class
subclass of: address question

What city
type: Class
subclass of: address question
subclass of: Restriction
  on property: is about
  some values from: city
alternative term: What is the city name?

What state
type: Class
subclass of: address question

What Zip code
type: Class
subclass of: What postal code
subclass of: Restriction
  on property: is about
  some values from: ZIP code

What street number and name
type: Class
subclass of: address question

What apartment
type: Class
subclass of: address question
alternative term: What apartment number

What country
type: Class
subclass of: address question
alternative term: Which country?

Whether have physician for usual medical care
type: Class
subclass of: physician question
alternative term: Do you have physician who provides your usual medical care?

nephrology care provider
type: Class
subclass of: secondary care provider
alternative term: nephrologist care provider

patient condition question
type: Class
subclass of: textual question
subclass of: Restriction
  on property: is about
  some values from: medical condition

Whether diabetic kidney disease (DKD)
type: Class
subclass of: Whether chronic kidney disease

Whether hypertensive CKD (H-CKD)
type: Class
subclass of: Whether chronic kidney disease

Whether diabetic nephropathy resisters percutaneous biopsy
type: Class
subclass of: Whether biopsy

Whether AKI percutaneous biopsy
type: Class
subclass of: Whether biopsy

Whether AKI open biopsy
type: Class
subclass of: Whether biopsy

Whether biopsy
type: Class
subclass of: patient condition question

CRF filled up by patient
type: Class
subclass of: case report form

What postal code
type: Class
subclass of: address question
subclass of: Restriction
  on property: is about
  some values from: postal code

CRF filled up by research coordinator
type: Class
subclass of: case report form

CRF filled up by biopsy operator
type: Class
subclass of: case report form

biopsy-related CRF
type: Class
subclass of: case report form
subclass of: Restriction
  on property: is about
  some values from: biopsy

post biopsy hospitlization form
type: Class
subclass of: hospitalization form

pathology CRF
type: Class
subclass of: case report form
definition: A clinical report form that is related to the processing and analysis of tissue of diseased patient.

screening and patient tracking CRF
type: Class
subclass of: case report form

enrollment CRF
type: Class
subclass of: case report form

Whether patient eligible to consent
type: Class
subclass of: eligibility question
definition: A eligibility question that asks whether a patient is eligible to consent to participate in a project.
definition editor: Oliver He, Edison Ong

HIPAA release
type: Class
subclass of: textual question

Whether patient signed HIPPA release form
type: Class
subclass of: HIPAA release

When HIPAA release form signed
type: Class
subclass of: HIPAA release

Whether scanned HIPAA release form uploaded
type: Class
subclass of: HIPAA release

hypertensive chronic kidney disease
type: Class
subclass of: chronic kidney disease
definition: A chronic kidney disease that is accompanied with elevated blood pressure or hypertension
definition editor: Oliver He
alternative term: H-CKD
definition source: https://www.nejm.org/doi/full/10.1056/NEJMoa0910975
comment: Oliver note: This term is not shown in MONDO or DOID. May request an addition.

biopsy
type: Class
subclass of: collecting specimen from organism
definition: a process that obtains a tissue from a living body in order to discover the presence, cause, or extent of a disease, or perform further biomeidcal investigation
definition editor: Oliver He, Hong Yu
definition source: https://en.oxforddictionaries.com/definition/biopsy
definition source: https://en.wikipedia.org/wiki/Biopsy

electronic health record
type: Class
subclass of: information content entity
definition: A systematized collection of patient and population electronically-stored health information in a digital format
definition editor: Oliver He, Edison Ong
alternative term: EHR
alternative term: EMR
alternative term: electronic medical record
definition source: https://en.wikipedia.org/wiki/Electronic_health_record
term mapping to NCIT ID: NCIT_C142529
comment: NCIT definition: A digital version of a patient's medical history. [def-source: NCI]

percutaneous biopsy
type: Class
subclass of: biopsy
definition: A biopsy that takes a small piece of tissue out of a living body through the skin, using only a tiny incision
definition editor: Oliver He, Hong Yu
definition source: http://www.wales.nhs.uk/sitesplus/documents/866/PIU433%284%29%28ABUHB%29%28Active%29%28JAN%2017%29.pdf

AKi percutaneous biopsy
type: Class
subclass of: percutaneous biopsy

open biopsy
type: Class
subclass of: biopsy
definition: A biopsy process in which a surgical incision (cut) is made through the skin to expose and remove tissues
definition editor: Oliver He, Hong Yu
definition source: https://en.wikipedia.org/wiki/Open_biopsy

AKI open biopsy
type: Class
subclass of: open biopsy

diabetic nephropathy resisters percutaneous biopsy
type: Class
subclass of: percutaneous biopsy

health status
type: Class
subclass of: status
definition: The state of being free from illness or injury
definition editor: Oliver He, Edison Ong
alternative term: health state
definition source: https://en.oxforddictionaries.com/definition/health
definition source: https://en.wikipedia.org/wiki/Health
definition source: https://www.healthknowledge.org.uk/public-health-textbook/research-methods/1c-health-care-evaluation-health-care-assessment/measures-health-status

medical condition
type: Class
subclass of: realizable entity
definition: The medical state or condition of a patient
definition editor: Oliver He, Edison Ong
alternative term: medical state
definition source: https://en.wikipedia.org/wiki/Medical_state

Whether diseased
type: Class
subclass of: patient condition question

Whether kidney diseased
type: Class
subclass of: Whether diseased

visit temporal region
type: Class
subclass of: zero-dimensional temporal region
definition: the date or time on which a visit occurs
definition editor: Oliver He
alternative term: clinical visit date
alternative term: visit time
term mapping to NCIT ID: NCIT_C83031
term mapping to UMLS CUI: C1320303

barcode
type: Class
subclass of: CRID
definition: a machine-readable centrally registered identifier that is represented in a visual format on a surface
alternative term: bar code
definition source: https://en.wikipedia.org/wiki/Barcode

specimen barcode
type: Class
subclass of: barcode
subclass of: Restriction
  on property: is about
  some values from: specimen
definition: a barcode that represents a specific specimen

tissue tracking
type: Class
subclass of: planned process
subclass of: Restriction
  on property: has_specified_input
  some values from: specimen from organism
definition: A planned process that tracks the tissue specimen including tissue vial number, storage location, time of vial arrival to storage, storage temperature, etc.
definition editor: Oliver He, Edison Ong

USA National Clinical Trial identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: clinical trial
definition: A centrally registered identifier that is assigned for a specific clinical trial registered in the ClinicalTrials.gov. The format for the ClinicalTrials.gov registry number is “NCT” followed by an 8-digit number, e.g.: NCT00000419.
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
alternative term: NCT identifier
alternative term: NCT number
alternative term: National Clinical Trial identifier
definition source: https://clinicaltrials.gov/ct2/about-site/link-to
definition source: https://www.nlm.nih.gov/bsd/policy/clin_trials.html

title of clinical trial
type: Class
subclass of: textual entity
definition: A textual entity that is the title of a clinical trial
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

official title of clinical trial
type: Class
subclass of: title of clinical trial
definition: A title of clinical trial that is recorded as official
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

lay title of clinical trial
type: Class
subclass of: title of clinical trial
definition: A title of clinical trial that is meant for lay people understanding
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

investigator
type: Class
equivalent class: Restriction
  on property: has role
  some values from: investigator role
subclass of: Homo sapiens
definition: A person who performs an investigation task and takes the role of an investigator role.
definition editor: Leon Li, Oliver He, Asiyah Lin
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

clinical investigator
type: Class
subclass of: investigator
definition: An investigator who is involved in a clinical trial and is responsible for ensuring that an investigation is conducted according to the signed investigator statement, the investigational plan, and applicable regulations; for protecting the rights, safety, and welfare of subjects under the investigator's care; and for the control of drugs under investigation.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Clinical_investigator

study start date
type: Class
subclass of: zero-dimensional temporal region
definition: The date on which a study starts

clinical trial start date
type: Class
subclass of: study start date
definition: The (estimated) date on which the clinical study is open for recruitment of participants, or the actual date on which the first participant is enrolled.
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

study completion date
type: Class
subclass of: zero-dimensional temporal region
definition: The date on which a study completes
definition editor: Oliver He

clinical trial study completion date
type: Class
subclass of: study completion date
definition: The date the final participant was examined or received an intervention for purposes of final collection of data for the primary and secondary outcome measures and adverse events (for example, last participant’s last visit), whether the clinical study concluded according to the pre-specified protocol or was terminated.
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

clinical trial primary completion date
type: Class
subclass of: study completion date
definition: The date that the final participant was examined or received an intervention for the purposes of final collection of data for the primary outcome, whether the clinical study concluded according to the pre-specified protocol or was terminated. In the case of clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all of the primary outcomes.
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

clinical trial primary purpose specification
type: Class
subclass of: objective specification
definition: The main objective of the intervention(s) being evaluated by the clinical trial.
alternative term: primary purpose of clinical trial
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

date of registration
type: Class
subclass of: zero-dimensional temporal region
definition: a date when a registration occurs

primary health outcome measurement datum
type: Class
subclass of: measurement datum
definition: A primary outcome measure used to describe patterns of diseases or traits or associations with exposures, risk factors or treatment.
alternative term: primary outcome
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

recruitment status
type: Class
subclass of: status
definition: The current stage of a clinical study and whether it is or will be open for enrollment
definition editor: Oliver He
definition source: https://clinicaltrials.gov/ct2/help/glossary/recruitment-status

electronic case report form
type: Class
subclass of: case report form
definition: A case report form that is presented in an electronic format
definition editor: Fred Dowd, Oliver He
alternative term: eCRF
definition source: https://en.wikipedia.org/wiki/Case_report_form#eCRF

clinical study participant candidate
type: Class
subclass of: Homo sapiens
definition: A human being who is a candidate to participant in a clinical study
definition editor: Fred Dowd, Oliver He

answering textual question
type: Class
subclass of: planned process
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
subclass of: Restriction
  on property: has input
  some values from: textual question

today's date
type: Class
subclass of: zero-dimensional temporal region
definition: a date of the present date
definition editor: Oliver He, Edison Ong

CRF filled up by participant candidate
type: Class
subclass of: case report form

pregnancy test positive
type: Class
subclass of: laboratory finding
definition editor: Fred Dowd, Edison Ong, Oliver He

hemoglobin test finding
type: Class
subclass of: laboratory finding
definition editor: Fred Dowd, Edison Ong, Oliver He

hemoglobin test positive with result < 9 g/dl
type: Class
subclass of: hemoglobin test finding
definition editor: Fred Dowd, Edison Ong, Oliver He
comment: In KPMP, the hemoglobin < 9 g/dl is considered as hemoblobin test positive.

date of first test
type: Class
subclass of: date of test
definition: a date when a test is performed at the first time
definition editor: Oliver He, Edison Ong

date of test
type: Class
subclass of: zero-dimensional temporal region
definition: a date when a test is performed
definition editor: Oliver He, Edison Ong

date of second test
type: Class
subclass of: date of test
definition: a date when a test is performed at the second time
definition editor: Oliver He, Edison Ong

person first and last name
type: Class
subclass of: person name
definition: A person name that includes both the first and last name
definition editor: Edison Ong, Oliver He
alternative term: first and last name
alternative term: human first and last name

sign date
type: Class
subclass of: zero-dimensional temporal region
definition: A date when a document is signed
definition editor: Oliver He, Edison Ong

status
type: Class
subclass of: realizable entity
definition editor: Oliver He, Edison Ong

study status
type: Class
subclass of: status
definition: The current stage of a clinical study and whether it is or will be open for enrollment
definition editor: Oliver He
definition source: https://clinicaltrials.gov/ct2/help/glossary/recruitment-status

patient status
type: Class
subclass of: status
definition editor: Oliver He, Edison Ong

exclusion criterion - obsolete
type: Class
subclass of: obsolete class
definition: a selection criterion (rule) which defines and states the exclusion condition for an entity to be considered as suitable for a given task or participation in a process.
definition editor: Oliver He, Edison Ong
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044655/
comment: Replace by a corresponding OBI term

bleeding exclusion criteria
type: Class
subclass of: exclusion criterion
definition: An exclusion criterion that relates to the process of bleeding
definition editor: Oliver He, Edison Ong

PROMIS form
type: Class
subclass of: case report form
definition: A case report form of PROMIS: Patient-Reported Outcomes Measurement Information System. PROMIS is a set of person-centered measures that evaluates and monitors physical, mental, and social health in adults and children. It can be used with the general population and with individuals living with chronic conditions.
definition editor: Fred Dowd, Edison Ong, Oliver He
alternative term: Patient-Reported Outcome Measures form
definition source: http://www.healthmeasures.net/explore-measurement-systems/promis

kit identifier
type: Class
subclass of: CRID

biopsy kit identifier
type: Class
subclass of: kit identifier
definition: A centrally registered identifier that is for a kit used in biopsy
definition editor: Fred Dowd, Edison Ong, Oliver He

KPMP PROMIS form
type: Class
subclass of: PROMIS form
subclass of: Restriction
  on property: has question
  some values from: what health status
definition: A PROMIS form that is designed and used by the KPMP project (http://kpmp.org).
definition editor: Oliver He

biopsy pass
type: Class
subclass of: biopsy
definition: A biopsy attempt
definition editor: Fred Dowd, Edison Ong, Oliver He

needle biopsy
type: Class
subclass of: biopsy
definition: A biopsy that uses needle
definition editor: Fred Dowd, Edison Ong, Oliver He

health status question
type: Class
equivalent class: Class
  intersection of: textual question
  intersection of: Restriction
    on property: is about
    some values from: health status
subclass of: textual question
subclass of: Restriction
  on property: is about
  some values from: health status
definition: A textual question about health condition
definition editor: Oliver He, Edison Ong

what health status
type: Class
subclass of: health status question
subclass of: Restriction
  on property: is about
  some values from: health status
definition: A health status question that asks about the condition of a person's heath, which can be a selection from different options such as Excellent, Very good, Good, Fair, or Poor.
definition editor: Oliver He, Edison Ong

excellent health status
type: Class
subclass of: health status

very good health status
type: Class
subclass of: health status

good health status
type: Class
subclass of: health status

fair health status
type: Class
subclass of: health status

poor health status
type: Class
subclass of: health status

quality of life
type: Class
subclass of: quality

excellent quality of life
type: Class
subclass of: quality of life

very good quality of life
type: Class
subclass of: quality of life

good quality of life
type: Class
subclass of: quality of life

fair quality of life
type: Class
subclass of: quality of life

poor quality of life
type: Class
subclass of: quality of life

consent status
type: Class
subclass of: status

unwilling to receive a blood transfusion
type: Class
subclass of: consent status
definition: A consent status that indicates a participant unwilling to receive a procedure of blood transfusion
definition editor: Edison Ong, Oliver He

willing to receive a blood transfusion
type: Class
subclass of: consent status
definition: A consent status that indicates a participate willing to receive a procedure of blood transfusion
definition editor: Edison Ong, Oliver He

year
type: Class
subclass of: one-dimensional temporal region

medical history question
type: Class
subclass of: textual question
alternative term: A textual quesition thta is about medical history of a person

What birth weight
type: Class
subclass of: medical history question
subclass of: Restriction
  on property: is about
  some values from: birth weight

Japan clinical trial identifier
type: Class
subclass of: CRID
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://pubchem.ncbi.nlm.nih.gov/source/NIPH%20Clinical%20Trials%20Search%20of%20Japan
definition source: https://rctportal.niph.go.jp/en/

UMIN-CTR clinical trial identifier
type: Class
subclass of: Japan clinical trial identifier
definition: A Japan clinical trial identifier provided by the University Hospital Medical Information Network Center (UMIN-CTR)
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://rctportal.niph.go.jp/en/

JAPIC clinical trial identifier
type: Class
subclass of: Japan clinical trial identifier
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://rctportal.niph.go.jp/en/

JMACCT clinical trial identifier
type: Class
subclass of: Japan clinical trial identifier
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://rctportal.niph.go.jp/en/

European clinical trial registry identifier
type: Class
subclass of: CRID
example of usage: EudraCT Number: 2007-002422-29
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
alternative term: EudraCT identifier
definition source: https://en.wikipedia.org/wiki/EudraCT
definition source: https://www.clinicaltrialsregister.eu/ctr-search/search

Phase I/II clinical trial
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: has process quality
    some values from: clinical trial phase 1
  intersection of: Restriction
    on property: has process quality
    some values from: clinical trial phase 2
subclass of: clinical trial
definition: A clinical trial that covers both Phase 1 and 2
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://en.wikipedia.org/wiki/Clinical_trial

combinational intervention
type: Class
subclass of: medical intervention
definition editor: Leon Li, Asiyah Lin, Oliver He

clinical trial phase
type: Class
subclass of: process quality
definition: The quality of a clinical trial that studies a drug or biological product. The phase is based on the study's objective, the number of participants, and other characteristics. According to USA FDA, there are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: clinical trial stage
definition source: https://www.clinicaltrials.gov/ct2/help/glossary/phase

clinical trial phase 1
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that represents the first-in-man trial, which tests within a small group of people (typically 20-80) to evaluate safety, determine safe dosage ranges, and begin to identify side effects. A drug's side effects could be subtle or long term, or may only happen with a few people, so phase 1 trials are not expected to identify all side effects.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase 1
alternative term: Phase I
definition source: http://purl.obolibrary.org/obo/NCIT_C15600
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0920321
NCIT code: C15600

clinical trial phase 2
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that is designed to study a biomedical or behavioral intervention in a larger group of people (several hundred), to evaluate the drug's effectiveness for a particular indication in patients with the disease or condition under study, and to determine the common short-term side effects and risks associated with the intervention. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase II
definition source: http://purl.obolibrary.org/obo/NCIT_C15601
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0282460
NCIT code: C15601

clinical trial phase 3
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that is designed to investigate the efficacy of the biomedical or behavioral intervention in large groups of human subjects (from several hundred to several thousand), to confirm efficacy, to monitor adverse reactions to the new medication or treatment regimen with respect to long-term use and by comparing the intervention to other standard or experimental interventions as well as to a placebo. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase III
definition source: http://purl.obolibrary.org/obo/NCIT_C15602
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0282461
NCIT code: C15602

clinical trial phase 4
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that is designed for a randomized, controlled trial to evaluate the long-term safety and efficacy of a drug for a given indication. Often they are designed to study side effects that may have become apparent after the phase III study was completed. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase IV
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0282462
NCIT code: C15603

clinical trial early phase 1
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that is designed to use an investigational agent that is available only in very limited quantities and which has never previously given to humans or for which there is extremely limited human experience. Phase 0 clinical trials are intended to enable researchers to understand the path of the drug in the body and its efficacy. Adverse event reporting in Phase 0 trials is expedited. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Early Phase 1
alternative term: Pre-Clinical Phase
alternative term: clinical trial phase 0
definition source: http://purl.obolibrary.org/obo/NCIT_C54721
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C1882358
NCIT code: C54721

Phase II/III clinical trial
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: has process quality
    some values from: clinical trial phase 2
  intersection of: Restriction
    on property: has process quality
    some values from: clinical trial phase 3
subclass of: clinical trial
definition: A clinical trial that covers both Phase 2 and 3
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://en.wikipedia.org/wiki/Clinical_trial

radiation
type: Class
subclass of: medical procedure
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: radiation procedure

genetic intervention
type: Class
subclass of: medical intervention
definition editor: Leon Li, Asiyah Lin, Oliver He

behavioral intervention
type: Class
subclass of: medical intervention
definition: A medical intervention that involves a behavioral process to control, prevent, or treat a behavior problem.
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://www.understood.org/en/learning-attention-issues/treatments-approaches/educational-strategies/behavior-intervention-plans-what-you-need-to-know

study accession identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: investigation
example of usage: ImmPort study accession: SDY269
definition editor: Edison Ong, Oliver He
alternative term: study accession

title of study
type: Class
subclass of: textual entity
definition editor: Edison Ong, Oliver He
alternative term: title of investigation

human subject
type: Class
subclass of: Homo sapiens
definition: A livinging individual who is or becomes a participant in research, either as a recipient of a test article or as a control. A subject may be either a healthy human or a patient. Based on the NIH definition, a living individual about whom an investigator (whether professional or student) conducting the following research: (1) Obtains information or biospecimens through intervention or interaction with the individual, and uses, studies, or analyzes the information or biospecimens; or (2) Obtains, uses, studies, analyzes, or generates identifiable private information or identifiable biospecimens.
definition editor: Oliver He, Anthony Huffman
definition source: https://grants.nih.gov/policy/humansubjects/research.htm
definition source: https://irb.research.chop.edu/who-human-subject
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

contact person
type: Class
equivalent class: Restriction
  on property: has role
  some values from: contact person role
subclass of: Homo sapiens
example of usage: In clinicaltrials.gov, contact information character limits: First Name: 62 characters Last Name: 62 characters Degree: 30 characters Phone: 30 characters Phone Ext: 14 characters Email: 254 characters Citation: https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials
definition: A person who serves as a contact role and has disclosed specified information to be reached. Usually the contact information, such as email and phone number, is provided.,
editor note: Leon, Asiyah, Oliver: Since each contact needs to provide some contact information, we may need to define the contact information.
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials

facility contact
type: Class
subclass of: contact person
definition: A contact person for each facility participating in a study.
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

biosample identifier
type: Class
subclass of: CRID

GSM identiifier
type: Class
subclass of: biosample identifier

ImmPort biosample identifier
type: Class
subclass of: biosample identifier
subclass of: Restriction
  on property: is about
  some values from: specimen

facility contact backup
type: Class
subclass of: contact person
definition: Person to contact if Facility Contact is not available (that is, a second contact person).
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials

contact of scientific queries
type: Class
subclass of: contact person
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials

investigator role
type: Class
subclass of: investigation agent role
subclass of: Restriction
  on property: characteristic of
  some values from: Homo sapiens
definition: An investigation agent role that is taken by a human individual
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: human investigator role

contact person role
type: Class
subclass of: role
definition: a role taken by a person who serves as a contact for some process.
definition editor: Leon Li, Asiyah Lin, Oliver He

Topical ocular hypotensive eye drops
type: Class
subclass of: medical procedure

contact for public queries
type: Class
subclass of: contact person
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials

overall study official
type: Class
subclass of: Homo sapiens
definition: A person who is responsible for the overall scientific leadership of the protocol, including study principal investigator
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html#StudyOfficials

central contact person of study
type: Class
subclass of: contact person
definition: A person to whom questions concerning enrollment at any location of the study can be addressed.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: central contact person
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

central contact backup of study
type: Class
subclass of: contact person
definition: A person to contact if Central Contact is not available.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: central contact person
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

contact person information
type: Class
equivalent class: Class
  intersection of: information content entity
  intersection of: Restriction
    on property: is about
    some values from: contact person
subclass of: information content entity
subclass of: Restriction
  on property: is about
  some values from: contact person
definition: information content entity about a contact person
definition editor: Leon Li, Asiyah Lin, Oliver He

primary sponsor role
type: Class
subclass of: sponsor role
definition: A sponsor role taken by an individual, organization, group or other legal entity which takes responsibility for initiating, managing and/or financing a study. The Primary Sponsor is responsible for ensuring that the trial is properly registered. The Primary Sponsor may or may not be the main funder.
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/

secondary sponsor role
type: Class
subclass of: sponsor role
definition: A sponsor role taken by an additional individual, organization or another legal person, if any, that has agreed with the primary sponsor to take on responsibilities of sponsorship.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: collaborator role
definition source: https://www.who.int/ictrp/network/trds/en/
comment: A secondary sponsor may have agreed to: - take on all the responsibilities of sponsorship jointly with the primary sponsor; or - form a group with the Primary Sponsor in which the responsibilities of sponsorship are allocated among the members of the group; or - act as the Primary Sponsor’s legal representative in relation to some or all of the trial sites. by WHO (https://www.who.int/ictrp/network/trds/en/)
comment: In clinicaltrials.gov, the secondary sponsor role can be taken by a project collaborator (Reference: https://prsinfo.clinicaltrials.gov/trainTrainer/WHO-ICMJE-ClinTrialsgov-Cross-Ref.pdf). However, a secondary sponsor may serve as a collaborator role, but a collaborator may not serve as a secondary sponsor role.

principal investigator role
type: Class
subclass of: investigator role
definition: An investigator role taken by an individual who is designated as responsible party by the sponsor
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

sponsor investigator role
type: Class
subclass of: investigator role
definition: An investigator role taken by an individual who both initiates and conducts the study
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

investigation collaborator role
type: Class
subclass of: investigation agent role
definition: An investigation agent role taken by an agent (an individual, organization, group or another legal entity) who provides support to an investigation. The support may include funding, design, implementation, data analysis or reporting. The responsible party is responsible for confirming all collaborators before listing them.
definition editor: Leon Li, Asiyah Li, Oliver He
alternative term: collaborator role
definition source: https://prsinfo.clinicaltrials.gov/definitions.html#Collaborators
definition source: https://www.who.int/ictrp/network/trds/en/
comment: A secondary sponsor may serve as a collaborator role. However, a collaborator may not serve as a secondary sponsor role.

inclusion criterion - obsolete
type: Class
subclass of: obsolete class
definition: a selection criterion (rule) which defines and states the inclusion condition for an entity to be considered as suitable for a given task or participation in a process.
definition editor: Oliver He, Edison Ong, Leon Li, Asiyah Lin
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044655/
comment: Replace by a corresponding OBI term

primary registry identifier
type: Class
equivalent class: Restriction
  on property: has role
  some values from: primary registry identifier role
subclass of: CRID
definition: A centrally registered unique identifier assigned by the primary registry to a study including a clinical trial.
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/

sponsor
type: Class
equivalent class: Restriction
  on property: has role
  some values from: sponsor role
subclass of: investigation agent
definition: An individual, organization, group or other legal entity that involves with any of the following activities: initiating, managing and funding a study
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/
term mapping to NCIT ID: NCIT_C48355

investigation agent
type: Class
subclass of: material entity

primary sponsor
type: Class
subclass of: sponsor
definition: The individual, organization, group or other legal entity which takes responsibility for initiating, managing and/or financing a study. In clinical trial, the Primary Sponsor is responsible for ensuring that the trial is properly registered. The Primary Sponsor may or may not be the main funder.
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/

secondary sponsor
type: Class
subclass of: sponsor
definition: An additional individual, organization or another legal person, if any, that has agreed with the primary sponsor to take on responsibilities of sponsorship.
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/
comment: A secondary sponsor may have agreed to: - take on all the responsibilities of sponsorship jointly with the primary sponsor; or - form a group with the Primary Sponsor in which the responsibilities of sponsorship are allocated among the members of the group; or - act as the Primary Sponsor’s legal representative in relation to some or all of the trial sites. Reference: https://www.who.int/ictrp/network/trds/en/

secondary registry identifier
type: Class
equivalent class: Restriction
  on property: has role
  some values from: secondary registry identifier role
subclass of: CRID
definition: A centrally registered unique identifier besides the primary registry identifier allocated by the Primary Registry, if any.
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/

collaborator
type: Class
subclass of: investigation agent
definition: An agent (an individual, organization, group or another legal entity) who provides support to an investigation. The support may include funding, design, implementation, data analysis or reporting. The responsible party is responsible for confirming all collaborators before listing them.
definition editor: Leon Li, Asiyah Li, Oliver He
alternative term: investigation collaborator
definition source: https://prsinfo.clinicaltrials.gov/definitions.html#Collaborators
definition source: https://www.who.int/ictrp/network/trds/en/

principal investigator
type: Class
equivalent class: Restriction
  on property: has role
  some values from: principal investigator role
subclass of: investigator
definition: An investigator who is designated as responsible party by the sponsor
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

sponsor investigator
type: Class
equivalent class: Restriction
  on property: has role
  some values from: sponsor investigator role
subclass of: investigator
definition: An investigator role taken by an individual who both initiates and conducts the study
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://prsinfo.clinicaltrials.gov/definitions.html

identifier role
type: Class
subclass of: role
definition: A role taken by a string (which may have mixed integer and text) that serves as a unique record.
definition editor: Leon Li, Asiyah Lin, Oliver He

obsolete class
type: Class
subclass of: entity

secondary registry identifier role
type: Class
subclass of: identifier role
definition: An identifier role that inheres in a unique record which provides an identifier secondary to the primary registry identifier.
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/

primary registry identifier role
type: Class
subclass of: identifier role
definition: An identifier role that is assigned by a primary registry and provides a unique record.
definition editor: Qingliang Leon Li, Asiyah Yu Lin, Oliver He
definition source: https://www.who.int/ictrp/network/trds/en/

patient
type: Class
equivalent class: Restriction
  on property: has role
  some values from: human patient role
subclass of: Homo sapiens
subclass of: Restriction
  on property: has identifier
  some values from: person ID
subclass of: Restriction
  on property: has role
  some values from: human patient role
definition: a human who is a recipient of a health care service performed by healthcare professionals.
alternative term: human patient
definition source: https://en.wikipedia.org/wiki/Patient
creator: Hong Yu, Oliver He

human subject study
type: Class
subclass of: investigation
definition: A systematic, scientific investigation that can be either interventional or observational and involves human beings as research subjects. Human subject research can be either medical (clinical) research or non-medical (e.g., social science) research.
definition editor: Oliver He
alternative term: human investigation
alternative term: human study
definition source: https://en.wikipedia.org/wiki/Human_subject_research

human cohort
type: Class
subclass of: collection of humans
definition: A collection of humans who share a defining characteristic, typically those who are collectively experiencing a common event (e.g., a clincal trial study) in a selected period.
definition editor: Anthony Huffman, Oliver He
definition source: https://en.wikipedia.org/wiki/Cohort_study

self-replicating organic structure
type: Class
subclass of: material entity
subclass of: Restriction
  on property: has part
  some values from: organic chemical entity
subclass of: Restriction
  on property: capable of
  some values from: self-replication
definition: A material entity that is composed of organic structure and is capable of self-replication (with or without host support). Various types of self-replicating organic structures can be found at: https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures.
definition editor: Oliver He
alternative term: organic self-replicating system
definition source: https://en.wikipedia.org/wiki/Self-replication
definition source: https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496545/

cellular organism
type: Class
subclass of: self-replicating organic structure
definition: A self-replicating organic structure that is composed of one cell or multiple cells and embodies the properties of life.
definition editor: Oliver He
alternative term: cellular self-replicating organic structure
alternative term: organism
definition source: https://en.wikipedia.org/wiki/Organism

acellular self-replicating organic structure
type: Class
subclass of: self-replicating organic structure
definition: A self-replicating organic structure that does not have the unit of cell but it may use the cells to replicate.
definition editor: Oliver He
alternative term: non-cellular self-replicating organic structure
alternative term: non-organism self-replicating organic structure
definition source: https://en.wikipedia.org/wiki/Self-replication

viroid
type: Class
subclass of: mobile genetic element
definition: An non-organism infectious agent that is composed solely of a short strand of circular, single-stranded RNA and has no protein coating.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Mobile_genetic_elements
definition source: https://en.wikipedia.org/wiki/Viroid

self-replication
type: Class
subclass of: process
definition: A process of a dynamic system that produces an identiical or similar copy of itself.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Self-replication

organic chemical entity
type: Class
subclass of: chemical entity

human subject age data
type: Class
subclass of: measurement datum
definition: A measurement datum that is about the age of human subject
definition editor: Oliver He, Jie Zheng, Anthony Huffman
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

child age data of human subject (by NIH)
type: Class
subclass of: human subject age data
definition: For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, a child is defined as an individual under the age of 18 years.
definition editor: Oliver He, Jie Zheng, Anthony Huffman
alternative term: child human subject
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

adult age data of human subject
type: Class
subclass of: human subject age data
definition: The regular aged adult group is defined here as an individual over 18 years of age.
definition editor: Oliver He, Jie Zheng, Anthony Huffman
alternative term: adult human subject
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

older adult data of human subject (by NIH)
type: Class
subclass of: adult age data of human subject
definition: For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, an older adult is defined as an individual 65 years of age or older.
definition editor: Oliver He, Jie Zheng, Anthony Huffman
alternative term: older adult human subject
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

positive diagnosis
type: Class
subclass of: diagnosis
definition: The representation of a positive conclusion of a diagnostic process, which indicates that the patient is diagnozed as positive for a hypothetic disease.
definition editor: Oliver He
alternative term in Chinese: 阳性诊断

negative diagnosis
type: Class
subclass of: diagnosis
definition: The representation of a negative conclusion of a diagnostic process, which indicates that the patient is diagnozed as negative for a hypothetic disease.
definition editor: Oliver He
alternative term in Chinese: 阴性诊断

presumptive positive diagnosis
type: Class
subclass of: diagnosis
definition: The representation of a presumptive positive conclusion of a diagnostic process, which indicates that the patient is diagnozed as presumptive positive for a hypothetic disease.
definition editor: Oliver He
alternative term in Chinese: 假定阳性诊断
alternative term in Chinese: 疑是诊断

child human subject
type: Class
subclass of: human subject
definition: A human subject classified as adult, which is defined by NIH as an individual under the age of 18 years. For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, a child is defined as an individual under the age of 18 years.
definition editor: Oliver He
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

older adult human subject
type: Class
subclass of: adult human subject
definition: A human subject classified as adult, which is defined by NIH as an individual 65 years of age or older. For the purposes of the NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects, an older adult is defined as an individual 65 years of age or older.
definition editor: Oliver He
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

adult human subject
type: Class
subclass of: human subject
definition: A human subject classified as adult, which is defined by NIH as an individual over 18 years of age.
definition editor: Oliver He
definition source: https://nexus.od.nih.gov/all/2018/08/07/human-subjects-and-clinical-trial-glossary-updates/

biomarker role
type: Class
subclass of: role
definition editor: Yingtong Liu, Anthony Huffman, Oliver He

immune signature role
type: Class
subclass of: biomarker role
definition editor: Anthony Huffman, Oliver He

cytokine signature role
type: Class
subclass of: immune signature role
definition editor: Anthony Huffman, Oliver He

inflammatory cytokine signature role
type: Class
subclass of: cytokine signature role
definition editor: Anthony Huffman, Oliver He

biomarker
type: Class
equivalent class: Restriction
  on property: has role
  some values from: biomarker role
subclass of: material entity
definition: A material entity that has a measurable quality or process profile(s), which can be used as an indicator of an underlying biological state or identity.
editor note: The NIH Biomarkers and Surrogate Endpoint Working Group defined a biomarker as “A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention” (https://pubmed.ncbi.nlm.nih.gov/11240971/). However, the definition of 'characteriistc' is unclear, so we do not use the exact definintion in the ontology.
definition editor: Yingtong Liu, Anthony Huffman, Oliver He
definition source: https://en.wikipedia.org/wiki/Biomarker
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)
definition source: https://en.wikipedia.org/wiki/Biomarker_(medicine)

immune biomarker
type: Class
subclass of: biomarker
definition editor: Anthony Huffman, Oliver He
definition source: A biomarker that is indicative of an immune response
definition source: https://pubmed.ncbi.nlm.nih.gov/22072636/
definition source: https://pubmed.ncbi.nlm.nih.gov/32286245/

cytokine biomarker
type: Class
subclass of: immune biomarker
definition editor: Anthony Huffman, Oliver He

inflammatory cytokine biomarker
type: Class
subclass of: cytokine biomarker
definition editor: Anthony Huffman, Oliver He

disease biomarker role
type: Class
subclass of: biomarker role
definition editor: Yingtong Liu, Anthony Huffman, Oliver He

disease biomarker
type: Class
subclass of: biomarker
definition: A biomarker that is indicative of a disease
definition editor: Yingtong Liu, Anthony Huffman, Oliver He
definition source: https://en.wikipedia.org/wiki/Biomarker_(medicine)

cell lineage biomarker
type: Class
subclass of: biomarker
definition: A biomarker that is an indicator of a cell lineage or cell type
definition editor: Yingtong Liu, Anthony Huffman, Oliver He
alternative term: cell marker
alternative term: cell type marker
definition source: https://en.wikipedia.org/wiki/Biomarker_(medicine)

molecular biomarker
type: Class
subclass of: biomarker
definition editor: Oliver He, Yingtong Liu
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers

cellular biomarker
type: Class
subclass of: biomarker
definition: Cellular biomarkers are marked cells that can be isolated, sorted, quantified and characterized by their morphology and physiology, and used in both clinical and laboratory settings for different biomarker applications. An example of a cellular biomarker sorting technique is Fluorescent-activated cell sorting.
definition editor: Oliver He, Yingtong Liu
definition source: https://en.wikipedia.org/wiki/Biomarker
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)#Cellular_Biomarkers

imaging biomarker
type: Class
subclass of: biomarker
definition editor: Oliver He, Yingtong Liu
definition source: https://en.wikipedia.org/wiki/Biomarker
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)#Imaging_Biomarkers

predictive biomarker
type: Class
subclass of: biomarker
definition: A biomarker that can predict clincal outcome.
definition editor: Oliver He, Yingtong Liu
definition source: https://en.wikipedia.org/wiki/Biomarker

prognostic biomarker
type: Class
subclass of: biomarker
definition: A biomarker that provides information about the patient's overall outcome, regardless of therapy.
definition editor: Oliver He, Yingtong Liu
definition source: https://en.wikipedia.org/wiki/Biomarker

diagnostic biomarker
type: Class
subclass of: biomarker
definition: A biomarker that can serve a role in narrowing down diagnosis, which can lead to diagnosis that is significantly more specific to individual patients.
definition editor: Oliver He, Yingtong Liu
definition source: https://en.wikipedia.org/wiki/Biomarker

DNA biomarker
type: Class
subclass of: molecular biomarker
definition: A molecular biomarker at the DNA gene level
definition: Oliver He, Yingtong Liu
alternative term: genomic biomarker
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers

RNA biomarker
type: Class
subclass of: molecular biomarker
definition: A molecular biomarker at the RNA level
definition: Oliver He, Yingtong Liu
alternative term: transcriptomic biomarker
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers

protein biomarker
type: Class
subclass of: molecular biomarker
definition: A molecular biomarker at the protein level
definition: Oliver He, Yingtong Liu
alternative term: proteomic biomarker
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)#Molecular_Biomarkers

imaging disease biomarker
type: Class
subclass of: disease biomarker
subclass of: imaging biomarker
definition: A biomarker that is indicative of a disease and achieved through imaging.
definition source: https://en.wikipedia.org/wiki/Biomarker_(medicine)#Imaging_disease_biomarkers_by_magnetic_resonance_imaging_(MRI)

susceptibility to biological regulation
type: Class
subclass of: disposition
definition: A disposition that a material entity (e.g., gene or protein) is susceptible to be up or down-regulated in an organism or virus.
definition editor: Oliver He, Anthony Huffman

imaging disease biomarkers by MRI
type: Class
subclass of: imaging disease biomarker
definition editor: Oliver He
alternative term: imaging disease biomarkers by magnetic resonance imaging
definition source: https://en.wikipedia.org/wiki/Biomarker_(medicine)#Imaging_disease_biomarkers_by_magnetic_resonance_imaging_(MRI)

cancer marker
type: Class
subclass of: disease biomarker
definition editor: Oliver He
definition source: A biomarker that is indicative of the presence of cancer in the body
definition source: https://en.wikipedia.org/wiki/Cancer_biomarker

susceptibility to biological up-regulation
type: Class
subclass of: susceptibility to biological regulation
definition: A disposition that a material entity (e.g., gene or protein) is susceptible to be up-regulated in an organism or virus.
definition editor: Oliver He, Anthony Huffman

susceptibility to biological down-regulation
type: Class
subclass of: susceptibility to biological regulation
definition: A disposition that a material entity (e.g., gene or protein) is susceptible to be down-regulated in an organism or virus.
definition editor: Oliver He, Anthony Huffman

Unified Social Credit Identifier
type: Class
subclass of: CRID
definition: A Unified Social Credit Identifier is issued to registered companies and other types of organization by the Chinese government.
definition editor: Suyuan Peng, Hong Yu, Oliver He
definition source: https://en.wikipedia.org/wiki/Unified_Social_Credit_Identifier
alternative term in Chinese: 组织机构代码

healthcare organization
type: Class
subclass of: organization
definition editor: Suyuan Peng, Hong Yu, Oliver He
alternative term: health care organization
definition source: https://www.sciencedirect.com/topics/nursing-and-health-professions/health-care-organization
alternative term in Chinese: 医疗机构

medical record number
type: Class
subclass of: CRID
definition: A centrality registered identifier for a medical record.
definition editor: Suyuan Peng, Hong Yu, Oliver He
alternative term: medical record ID
definition source: https://en.wikipedia.org/wiki/Medical_record
alternative term in Chinese: 病案号

person ID
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: A centrally registered identifier that is uniquely assigned to a person.
definition editor: Oliver He, Long Tran
definition source: https://www.ohdsi.org/web/wiki/doku.php

number of hospital admissions
type: Class
subclass of: hospital question
definition: 指患者在本医疗机构住院诊治的次数 @zh
definition editor: Suyuan Peng, Hong Yu, Oliver He
definition source: 《卫生部关于修订住院病案首页的通知》卫医政发〔2011〕84号 @zh
alternative term in Chinese: 住院次数 @zh

date of hospital admission
type: Class
subclass of: time measurement datum
definition: A time measurement datum that is about a human being who bears a patient role and specifies the date of the patient's admission to a hospital
definition: 指患者实际入病房的接诊时间 @zh
definition editor: Suyuan Peng, Hong Yu, Oliver He
definition source: http://purl.obolibrary.org/obo/EUPATH_0000319
definition source: 《住院病案首页数据填写质量规范（暂行）》国卫办医发〔2016〕24号 @zh
alternative term in Chinese: 入院时间 @zh

year of birth
type: Class
subclass of: year
subclass of: birth-related time
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: A year when an organism (e.g., a human) is born.
definition editor: Oliver He, Long Tran
definition source: https://www.ohdsi.org/web/wiki/doku.php

month of birth
type: Class
subclass of: month of year
subclass of: birth-related time
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: A month when an organism (e.g., a human) is born.
definition editor: Oliver He, Long Tran
definition source: https://www.ohdsi.org/web/wiki/doku.php

birth datetime
type: Class
subclass of: birth-related time
subclass of: Restriction
  on property: is about
  some values from: Homo sapiens
definition: The date and time of birth of a person.
definition editor: Oliver He, Long Tran
definition source: https://www.ohdsi.org/web/wiki/doku.php
comment: This term is generated to be equivalent to the "birth_datetime" in OMOP. Also note: in OMOP v6.0, DATETIME fields were made mandatory and date fields were made optional. Reference: https://ohdsi.github.io/CommonDataModel/cdm60.html#PERSON

date of hospital discharge
type: Class
subclass of: time measurement datum
definition: A time measurement datum that is about a human being who bears a patient role and specifies the date of the patient's discharge from a hospital
definition: 出院时间是指患者治疗结束或终止治疗离开病房的时间，其中死亡患者是指其死亡时间；记录时间应当精确到分钟 @zh
definition editor: Suyuan Peng, Hong Yu, Oliver He
definition source: http://purl.obolibrary.org/obo/EUPATH_0000320
definition source: 《住院病案首页数据填写质量规范（暂行）》国卫办医发〔2016〕24号 @zh
alternative term in Chinese: 入院时间 @zh

residents health card number
type: Class
subclass of: personal information
definition: The number of health card for residents of the People's Republic of China
definition: 在已统一发放“中华人民共和国居民健康卡”的地区填写健康卡号码，尚未发放“健康卡”的地区填写“-” @zh
definition editor: Suyuan Peng, Hong Yu, Yongqun He @zh
definition source: 《卫生部关于修订住院病案首页的通知》卫医政发〔2011〕84号 @zh
alternative term in Chinese: 健康卡号 @zh

birth-related time
type: Class
subclass of: one-dimensional temporal region
definition: time that is related to the birth
definition editor: Oliver He, Long Tran
alternative term: time of birth

care site
type: Class
subclass of: site
subclass of: Restriction
  on property: has identifier
  some values from: care site identifier
definition: A care site is a uniquely identified institutional (physical or organizational) unit where healthcare delivery is practiced, for example, office, ward, hospital, clinic, etc.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#CARE_SITE
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON
definition source: https://en.wikipedia.org/wiki/Health_care
comment: According to OMOP, care site does not consider the provider (human) information such a specialty. Instead, care site is considered at the institutional level.

care site identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: care site
definition: A centrally registered identifier that refers to where the care provider typically provides the primary care.
definition editor: Oliver He, Long Tran
alternative term: care site id
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#CARE_SITE
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON

medical visit
type: Class
subclass of: medical occurrence
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A medical occurrence where a person engages with the healthcare system for a duration of time.
definition editor: Oliver He, Long Tran
alternative term: visit occurrence
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

visit occurrence identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: medical visit
definition: A centrally registered identifier that refers to a specific visit occurrence. This identifier identifies a unique interaction between a person and the health care system.
definition editor: Oliver He, Long Tran
alternative term: visit occurrence id
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

inpatient visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A vist ocurrence in which the patient's condition requires admission to a hospital.
definition editor: Oliver He, Long Tran
alternative term: inpatient visit occurrence
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Inpatient_care

outpatient visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A vist ocurrence in which a patient attends an outpatient clinic with no plan to stay beyond the duration of the visit.
definition editor: Oliver He, Long Tran
alternative term: outpatient visit occurrence
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

emergency room visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A vist ocurrence in which a patient attends an outpatient clinic with no plan to stay beyond the duration of the visit.
definition editor: Oliver He, Long Tran
alternative term: ER visit
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

visit start date
type: Class
subclass of: visit temporal region
definition: The date on which a visit starts. In the case of an inpatient visit this should be the date the patient was admitted to the hospital or institution. In all other cases this should be the date of the patient-provider interaction.
definition editor: Oliver He, Long Tran
alternative term: clinical visit start date
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

visit end date
type: Class
subclass of: visit temporal region
definition: The date on which a visit ends. For inpatient visits the end date is typically the discharge date. If a Person is still an inpatient in the hospital at the time of the data extract and does not have a visit_end_date, then set the visit_end_date to the date of the data pull.
definition editor: Oliver He, Long Tran
alternative term: clinical visit end date
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

visit duration
type: Class
subclass of: one-dimensional temporal region
definition: A temporal region that covers the time period from the visit start time to the visit end time.
definition editor: Oliver He, Long Tran

visit start datetime
type: Class
subclass of: visit temporal region
definition: The date and time on which a visit starts. In the case of an inpatient visit this should be the date the patient was admitted to the hospital or institution. In all other cases this should be the date of the patient-provider interaction.
definition editor: Oliver He, Long Tran
alternative term: clinical visit start datetime
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

visit end datetime
type: Class
subclass of: visit temporal region
definition: The date and time on which a visit ends. For inpatient visits the end date is typically the discharge date. If a Person is still an inpatient in the hospital at the time of the data extract and does not have a visit_end_date, then set the visit_end_date to the date of the data pull.
definition editor: Oliver He, Long Tran
alternative term: clinical visit end datetime
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

preceding medical visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A visit occurrence that occurs for the person prior to the given visit. There could be a few days or a few years in between.
definition editor: Oliver He, Long Tran
alternative term: preceding visit
alternative term: preceding visit occurrence
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

emergency room and inpatient visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A vist ocurrence that includes a visit to the emergency room followed by a subsequent inpatient visit.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

non-hospital institution visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A visit to a dedicated institution for reasons of poor health, at a Care Site, long-term or permanently, with no physician but possibly other Providers permanently available to deliver service around the clock
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

home medical visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A visit where a provider visits a person, without a care site, within one day, delivering service
definition editor: Oliver He, Long Tran
alternative term: home visit
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

telehealth visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A visit in which a patient engages with a Provider through communication media. A patient can use digital information and communication technologies, such as computers and mobile devices, to access health care services remotely and manage their health care.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

pharmacy visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A visit to the pharmacy for dispensing of drug, at a care site, within one day
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

laboratory medical visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A visit to a dedicated institution, at a care site, within one day, for the purpose of a measurement. The visit is carried out in a medical laboratory or clinical laboratory where tests are carried out on clinical specimens to obtain information about the health of a patient to aid in diagnosis, treatment, and prevention of disease
definition editor: Oliver He, Long Tran
alternative term: laboratory clinical visit
alternative term: laboratory visit
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

case management visit
type: Class
subclass of: medical visit
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A medical visit occurrence that involves an interaction with the healthcare system, without a care site, within a day, with no providers involved, for the administrative purpose of patient case management.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE
definition source: https://en.wikipedia.org/wiki/Patient#Outpatients_and_inpatients

home
type: Class
subclass of: site
definition: A site that is used as a permanent or semi-permanent residence for one or many humans.
definition editor: Long Tran, Oliver He
definition source: https://en.wikipedia.org/wiki/Home

National Provider Identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: care site
definition: A centrally registered identifier that refers to the National Provider Number issued to health care providers in the US by the Centers for Medicare and Medicaid Services (CMS). NPI is assigned for use in all administrative and financial transactions specified by HIPAA.
definition editor: Oliver He, Long Tran
alternative term: National Providier Number
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON
term_mapping_to_NCIT: http://purl.obolibrary.org/obo/NCIT_C54633

DEA identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: care site
definition: A centrally registered identifier that is issued by the Drug Enforcement Administration (DEA), a US federal agency, that allows a provider to write prescriptions for controlled substances.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PERSON
definition source: https://en.wikipedia.org/wiki/Drug_Enforcement_Administration

medical procedure occurrence
type: Class
subclass of: medical occurrence
subclass of: Restriction
  on property: has identifier
  some values from: procedure occurrence identifier
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A medicl occurrence that is ordered by, or carried out by, a healthcare provider on a patient with a diagnostic or therapeutic purpose.
definition editor: Oliver He, Long Tran
alternative term: procedure occurrence
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

procedure occurrence identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: medical procedure occurrence
definition: A centrally registered identifier that refers to a procedure occurrence, which is an activity or process that is ordered by, or carried out by, a healthcare provider on a patient with a diagnostic or therapeutic purpose.
definition editor: Oliver He, Long Tran
alternative term: procedure occurrence ID
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

procedure temporal region
type: Class
subclass of: zero-dimensional temporal region
definition: A temporal region that is associated with a procedure
definition editor: Long Tran, Oliver He
alternative term: procedure time
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

procedure start date
type: Class
subclass of: procedure temporal region
definition: The date when a procedure starts
definition editor: Long Tran, Oliver He
alternative term: procedure date
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

procedure start datetime
type: Class
subclass of: procedure temporal region
definition: The date and time when a procedure starts
definition editor: Long Tran, Oliver He
alternative term: procedure date
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

procedure end date
type: Class
subclass of: procedure temporal region
definition: The date when a procedure ends
definition editor: Long Tran, Oliver He
alternative term: procedure date
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

procedure end datetime
type: Class
subclass of: procedure temporal region
definition: The date and time when a procedure ends
definition editor: Long Tran, Oliver He
alternative term: procedure date
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

provenance of record
type: Class
subclass of: information content entity
definition: The information content entity that represents the origin of record such as the clinical form as the origin record of death.
definition editor: Oliver He, Long Tran
alternative term: type concept
definition source: https://github.com/OHDSI/Vocabulary-v5.0/wiki/Vocab.-TYPE_CONCEPT

provenance of procedure record
type: Class
subclass of: provenance of record
example of usage: As part of the OMOP CDM, PROCEDURE TYPE CONCEPT best represents the provenance of the record, for example whether it came from an EHR record or billing claim. If a procedure is recorded as an EHR encounter, the PROCEDURE_TYPE_CONCEPT would be ‘EHR encounter record’.
definition: A provenance of record that determines the provenance of the Procedure record, as in whether the procedure was from an EHR system, insurance claim, registry, or other sources.
definition editor: Long Tran, Oliver He
alternative term: Procedure Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

death diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: death diagnosis
definition: The status of being diagnosed as death
definition editor: Oliver He, Long Tran
alternative term: death diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms/32895
definition source: https://athena.ohdsi.org/search-terms/terms

provenance of cost record
type: Class
subclass of: provenance of record
definition: A provenance of record that designates the source (provenance) of the cost data.
definition editor: Long Tran, Oliver He
alternative term: Cost Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#COST

provenance of death record
type: Class
subclass of: provenance of record
example of usage: As part of the OMOP CDM, use the type concept that be reflects the source of the death record. It is possible that an administrative claims database would source death information from a government file so do not assume the Death Type is the same as the Visit Type, etc.
definition: A provenance of record that determines the provenance of the death record, i.e., where it came from.
definition editor: Long Tran, Oliver He
alternative term: Death Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#DEATH

provenance of device record
type: Class
subclass of: provenance of record
definition: A provenance of record that determines the provenance of the record, as in whether the record is from administrative claims or EHR.
definition editor: Long Tran, Oliver He
alternative term: Device Exposure Type Concept
alternative term: Device Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

provenance of drug record
type: Class
subclass of: provenance of record
example of usage: As part of the OMOP CDM, choose the drug_type_concept_id that best represents the provenance of the record, for example whether it came from a record of a prescription written or physician administered drug.
definition: A provenance of record that determines the provenance of a drug prescription, which delineates prescriptions written, prescriptions dispensed, medication history, patient-reported exposure, etc.
definition editor: Long Tran, Oliver He
alternative term: Drug Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

provenance of episode record
type: Class
subclass of: provenance of record
definition: A provenance of record that determines the provenance of the Episode record, as in whether the procedure was from an EHR system, insurance claim, registry, or other sources.
definition editor: Long Tran, Oliver He
alternative term: Procedure Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#EPISODE

provenance of measurement record
type: Class
subclass of: provenance of record
definition: A provenance of record that determines the provenance of the Measurement record, as in whether the procedure was from an EHR system, insurance claim, registry, or other sources.
definition editor: Long Tran, Oliver He
alternative term: Measurement Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT

provenance of note record
type: Class
subclass of: provenance of record
example of usage: As part of the OMOP CDM, the provenance of the notes most likely will be EHR.
definition: A provenance of record that determines the provenance of the note.
definition editor: Long Tran, Oliver He
alternative term: Note Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#NOTE

provenance of observation record
type: Class
subclass of: provenance of record
definition: A provenance of record that determines the provenance of the Observation record, as in whether the measurement was from an EHR system, insurance claim, registry, or other sources.
definition editor: Long Tran, Oliver He
alternative term: Observation Period Type Concept
alternative term: Observation Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#OBSERVATION

provenance of specimen record
type: Class
subclass of: provenance of record
definition: A provenance of record that determines the source of the specimen record, as in an EHR system.
definition editor: Long Tran, Oliver He
alternative term: Specimen Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#SPECIMEN

provenance of visit record
type: Class
subclass of: provenance of record
example of usage: As part of the OMOP CDM, populate this field based on the provenance of the visit record, as in whether it came from an EHR record or billing claim.
definition: A provenance of record that determines the provenance of the visit record, or where the record comes from.
definition editor: Long Tran, Oliver He
alternative term: Visit Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

provenance of condition occurrence record
type: Class
subclass of: provenance of record
definition: A provenance of record that determines the provenance of the Condition record, as in whether the condition was from an EHR system, insurance claim, registry, or other sources.
definition editor: Long Tran, Oliver He
alternative term: Condition Occurrence Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

primary diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: primary diagnosis
definition: The primary diagnosis refers to the patient condition that demands the most provider resources during the patient’s stay.
definition editor: Oliver He, Long Tran
alternative term: primary diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms/32902
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://www.definitivehc.com/resources/glossary/primary-diagnosis
comment: There is often confusion surrounding primary and principal diagnoses and, consequently, the terms are commonly used interchangeably. While these can be (and frequently are) the same diagnosis in practice, their definitions are distinct. While a principal diagnosis is the underlying cause of patient symptoms, the primary diagnosis is used for healthcare billing purposes. Reference: https://www.definitivehc.com/resources/glossary/primary-diagnosis

medical condition occurrence
type: Class
subclass of: medical occurrence
subclass of: Restriction
  on property: has_participant
  some values from: Homo sapiens
definition: A medicl occurrence where a person presents a disease or medical condition stated as a diagnosis, a sign, or a symptom, which is either observed by a Provider or reported by the patient.
definition editor: Oliver He, Long Tran
alternative term: condition occurrence
alternative term: medical condition occurrence
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

condition temporal region
type: Class
subclass of: zero-dimensional temporal region
definition: the date or time on which a condition occurs
definition editor: Oliver He, Long Tran
alternative term: clinical condition date
alternative term: condition time
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

condition end date
type: Class
subclass of: condition temporal region
definition: The date on which a condition ends.
definition editor: Oliver He, Long Tran
alternative term: clinical condition end date
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

condition end datetime
type: Class
subclass of: condition temporal region
definition: The date and time on which a clinical condition ends.
definition editor: Oliver He, Long Tran
alternative term: clinical condition end datetime
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

condition start date
type: Class
subclass of: condition temporal region
definition: The date on which a condition starts.
definition editor: Oliver He, Long Tran
alternative term: clinical condition start date
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

condition start datetime
type: Class
subclass of: condition temporal region
definition: The date and time on which a condition starts.
definition editor: Oliver He, Long Tran
alternative term: clinical condition start datetime
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE
comment: In OMOP CDM, most often data sources do not have the idea of a start date for a condition. Rather, if a source only has one date associated with a condition record it is acceptable to use that date for both the CONDITION_START_DATE and the CONDITION_END_DATE. Reference: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

medical condition status
type: Class
subclass of: status
definition: The state or status at the point during the visit the diagnosis was given (admitting diagnosis, final diagnosis), whether the diagnosis was determined due to laboratory findings, if the diagnosis was exclusionary, or if it was a preliminary diagnosis, among others.
definition editor: Oliver He, Long Tran
alternative term: diagnosis status
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://build.fhir.org/ig/HL7/UTG/CodeSystem-condition-clinical.html
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE
comment: In OPMI, we treated medical condition status as a status, which is a realizable entitry. One major section of the branch is various diagnosis condition status. There are basically two types of diagnosis: one type diagnosis is treated as a condition status, the other is diagnosis (OGMS_0000073) as a type of clinical data item. One good example to illustrate the difference is the difference between primary and principal diagnoses. While these can be (and frequently are) the same diagnosis in practice, their definitions are distinct. While a principal diagnosis is the underlying cause of patient symptoms, the primary diagnosis is used for healthcare billing purposes and is a type of medical condition status. Reference: https://www.definitivehc.com/resources/glossary/primary-diagnosis

medical condition stop reason specification
type: Class
subclass of: action specification
definition: An action specification that indicates why a Condition is no longer valid with respect to the purpose specified within the source data.
definition editor: Oliver He, Long Tran
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE
comment: In OMOP CDM, a Stop Reason does not necessarily imply that the condition is no longer occurring.

primary admission diagnosis status
type: Class
subclass of: primary diagnosis status
subclass of: Restriction
  on property: has status content
  some values from: primary admission diagnosis
definition: The status of have the primary admission diagnosis
definition editor: Oliver He, Long Tran
alternative term: primary admission diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms/32901
definition source: https://athena.ohdsi.org/search-terms/terms

confirmed diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: confirmed diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

principal diagnosis
type: Class
subclass of: diagnosis
definition: Principal diagnosis describes the underlying cause behind a patient’s initial hospital admission and is assigned only after a physician has completed necessary tests and examinations.
definition editor: Oliver He, Long Tran
definition source: https://www.definitivehc.com/resources/glossary/principal-diagnosis

discharge diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: discharge diagnosis
definition: A discharge diagnosis is a final diagnosis given a patient before release from the hospital after all testing, surgery, and workup are complete.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://medical-dictionary.thefreedictionary.com/discharge+diagnosis

postoperative diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: postoperative diagnosis
definition: A postoperative diagnosis is a diagnosis or diagnoses discovered or confirmed during the surgery. Often it is the same as the preoperative diagnosis.
definition editor: Oliver He, Long Tran
alternative term: primary admission diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85779000#:~:text=Definition%3A,same%20as%20the%20Preoperative%20Diagnosis.

preliminary diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: preliminary diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

preoperative diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: preoperative diagnosis
definition: A preoperative diagnosis is a surgical diagnosis or diagnoses that are assigned to the patient before the surgical procedure, and is the reason for the surgery. A preoperative diagnosis is, in the opinion of the surgeon, the diagnosis that will be confirmed during surgery.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85778000#:~:text=Definition%3A,will%20be%20confirmed%20during%20surgery.

admission diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: admission diagnosis
definition: An admitting diagnosis is defined as the initial working diagnosis documented by the patient's admitting or attending physician who determined that inpatient care was necessary.
definition editor: Oliver He, Long Tran
alternative term: admission diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://manual.jointcommission.org/releases/TJC2016B/DataElem0540.html#:~:text=Definition%3A&text=The%20admitting%20diagnosis%20is%20defined,that%20inpatient%20care%20was%20necessary.

cause of death status
type: Class
subclass of: medical condition status
definition: A cause of death is an official determination of conditions resulting in a human's death, which may be recorded on a death certificate. A cause of death is determined by a medical examiner.
definition editor: Oliver He, Long Tran
alternative term: cause of death
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://en.wikipedia.org/wiki/Cause_of_death
definition source: https://www.cdc.gov/nchs/data/misc/hb_cod.pdf

primary referral diagnosis status
type: Class
subclass of: primary diagnosis status
subclass of: referral diagnosis status
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

referral diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: referral diagnosis
definition: A referral is a written request from one health professional to another health professional or health service, asking them to diagnose or treat you for a particular condition.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://www.healthdirect.gov.au/what-is-a-referral#:~:text=A%20referral%20is%20a%20written,you%20for%20a%20particular%20condition.

secondary diagnosis status
type: Class
subclass of: medical condition status
subclass of: Restriction
  on property: has status content
  some values from: secondary diagnosis
definition: A secondary diagnosis is a condition that coexists at the time of admission, that develops subsequently, or that affects the treatment received and/or length of stay.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://medcom.uiowa.edu/theloop/announcements/understanding-principal-and-secondary-conditions-2

secondary discharge diagnosis status
type: Class
subclass of: discharge diagnosis status
subclass of: secondary diagnosis status
subclass of: Restriction
  on property: has status content
  some values from: secondary discharge diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

secondary referral diagnosis status
type: Class
subclass of: referral diagnosis status
subclass of: secondary diagnosis status
subclass of: Restriction
  on property: has status content
  some values from: secondary referral diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

preliminary admission diagnosis status
type: Class
subclass of: preliminary diagnosis status
subclass of: admission diagnosis status
subclass of: Restriction
  on property: has status content
  some values from: preliminary admission diagnosis
definition: The status of have the primary admission diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms/32901
definition source: https://athena.ohdsi.org/search-terms/terms

preliminary discharge diagnosis status
type: Class
subclass of: discharge diagnosis status
subclass of: preliminary diagnosis status
subclass of: Restriction
  on property: has status content
  some values from: preliminary discharge diagnosis
definition: The status of have the primary admission diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms/32901
definition source: https://athena.ohdsi.org/search-terms/terms

condition to be diagnosed by procedure status
type: Class
subclass of: medical condition status
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

contributory cause of death status
type: Class
subclass of: medical condition status
definition: A contributory cause of death is a significant condition that unfavourably influences the course of the morbid process and thus contributes to the fatal outcome, but which is not related to the disease or condition directly causing death.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://stats.oecd.org/glossary/detail.asp

immediate cause of death status
type: Class
subclass of: cause of death status
definition: An immediate cause of death is a final disease, injury, or complication directly causing the death
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://www.cdc.gov/nchs/data/misc/hb_cod.pdf

medical device exposure
type: Class
subclass of: medical exposure
definition: A process of a person’s exposure to a foreign physical object or instrument which is used for diagnostic or therapeutic purposes through a mechanism beyond chemical action. Devices include implantable objects (e.g. pacemakers, stents, artificial joints), medical equipment and supplies (e.g. bandages, crutches, syringes), other instruments used in medical procedures (e.g. sutures, defibrillators) and material used in clinical care (e.g. adhesives, body material, dental material, surgical material).
definition editor: Oliver He, Long Tran
alternative term: device exposure
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

primary discharge diagnosis status
type: Class
subclass of: primary diagnosis status
subclass of: discharge diagnosis status
subclass of: Restriction
  on property: has status content
  some values from: primary discharge diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

device exposure temporal region
type: Class
subclass of: zero-dimensional temporal region
definition: the date or time on which a device exposure occurs
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

device exposure end date
type: Class
subclass of: device exposure temporal region
definition: The date on which a device exposure ends.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE
comment: "Put the end date or discontinuation date as it appears from the source data or leave blank if unavailable." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

device exposure end datetime
type: Class
subclass of: device exposure temporal region
definition: The date and time on which a device exposure ends.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE
comment: "If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

secondary admission diagnosis status
type: Class
subclass of: admission diagnosis status
subclass of: secondary diagnosis status
subclass of: Restriction
  on property: has status content
  some values from: secondary admission diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

resolved condition status
type: Class
subclass of: medical condition status
definition: A medical condition status in which the subject is not presently experiencing the condition or situation and there is a negligible perceived risk of the condition or situation returning.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms/32906
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://build.fhir.org/ig/HL7/UTG/CodeSystem-condition-clinical.html

underlying cause of death status
type: Class
subclass of: cause of death status
definition: The underlying cause of death refers to the disease or injury that initiated the train of morbid events leading directly to death or the circumstances of the accident or violence that produced the injury.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://stats.oecd.org/glossary/detail.asp
definition source: https://www.cdc.gov/nchs/data/misc/hb_cod.pdf

device exposure start date
type: Class
subclass of: device exposure temporal region
definition: The date on which a device exposure starts.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE
comment: "Valid entries include a start date of a procedure to implant a device, the date of a prescription for a device, or the date of device administration." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

device exposure start datetime
type: Class
subclass of: device exposure temporal region
definition: The date and time on which a device exposure starts.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE
comment: "This is not required, though it is in v6. If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)." http://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

drug exposure temporal region
type: Class
subclass of: zero-dimensional temporal region
definition: the date or time on which a drug exposure occurs in a patient
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug exposure start date
type: Class
subclass of: drug exposure temporal region
definition: The date on which a drug exposure starts.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE
comment: "Valid entries include a start date of a prescription, the date a prescription was filled, or the date on which a Drug administration was recorded. It is a valid ETL choice to use the date the drug was ordered as the DRUG_EXPOSURE_START_DATE." http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug exposure start datetime
type: Class
subclass of: drug exposure temporal region
definition: The date and time on which a drug exposure starts.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE
comment: "This is not required, though it is in v6. If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)." http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug exposure end date
type: Class
subclass of: drug exposure temporal region
definition: The date on which a drug exposure ends for a patient.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug exposure end datetime
type: Class
subclass of: drug exposure temporal region
definition: The date and time on which a drug exposure ends for a patient.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE
comment: "This is not required, though it is in v6. If a source does not specify datetime the convention is to set the time to midnight (00:00:0000)". http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug exposure stop reason specification
type: Class
subclass of: action specification
definition: The reason a person stopped a medication as it is represented in the source. Reasons include regimen completed, changed, removed, etc.
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE
comment: This information is often not populated in source data and it is a valid etl choice to leave it blank if the information does not exist. This field will be retired in v6.0 of the OMOP CDM, . http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug refills specification
type: Class
subclass of: action specification
definition: An action specification that represents the intended refills at time of the prescription.
definition editor: Oliver He, Long Tran
alternative term: drug refills specification from prescription
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE
comment: This is only filled in when the record is coming from a prescription. http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug exposure verbatim end date
type: Class
subclass of: drug exposure temporal region
definition: The end date of a drug exposure as it appears in the source data
definition editor: Oliver He, Long Tran
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

drug exposure
type: Class
subclass of: medical exposure
definition: An exposure or contact of a person to a drug. The drug exposure includes drug dispensing or administration for a person.
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE
curator note: This term is used in OMOP CDM. This term appears similar to 'drug administration'. However, drug exposure also covers involuntary, but drug administration usually means voluntary. More discussion is needed.
term mapping to NCIT ID: http://purl.obolibrary.org/obo/NCIT_C41362

quantity of drug exposure
type: Class
subclass of: measurement datum
example of usage: In drug exposure, the quantity refers to number of pieces, e.g. tablets. In the example: 20 Ingredient dose= quantity x amount_value [amount_unit_concept_id] Acetaminophen dose = 20 x 500mg = 10,000mg Daily dose = Acetaminophen dose/drug duration
definition: The quantity of drug exposure refers to the number of drug pieces, e.g. tablets, that are exposed to a person.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE
definition source: https://ohdsi.github.io/CommonDataModel/drug_dose.html

days of drug supply
type: Class
subclass of: measurement datum
definition: This days of the supply of a drug that is given on the prescription.
definition editor: Long Tran, Oliver He
alternative term: days supply of drug
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

observation period
type: Class
subclass of: one-dimensional temporal region
subclass of: observation temporal region
subclass of: Restriction
  on property: has part
  some values from: observation period start date
subclass of: Restriction
  on property: has part
  some values from: observation period end date
definition: A period time when an observation is conducted.
definition editor: Oliver He, Long Tran
alternative term: participant observation duration time
definition source: https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD
comment: In OMOP, the observation table contains records that defines spans of time during which two conditions are expected to hold: (i) Clinical Events that happened to the Person are recorded in the Event tables, and (ii) absense of records indicate such Events did not occur during this span of time.

observation temporal region
type: Class
subclass of: temporal region
definition: A temporal region that is associated with an observation
definition editor: Long Tran, Oliver He
definition source: https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD

observation period start date
type: Class
subclass of: zero-dimensional temporal region
subclass of: observation temporal region
definition: A date when an observation starts.
definition editor: Long Tran, Oliver He
definition source: https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD

observation period end date
type: Class
subclass of: zero-dimensional temporal region
subclass of: observation temporal region
definition: A date when an observation ends.
definition editor: Long Tran, Oliver He
definition source: https://ohdsi.github.io/CommonDataModel/cdm60.html#OBSERVATION_PERIOD

measurement time
type: Class
subclass of: zero-dimensional temporal region
definition: A time when a measurement is conducted.
definition editor: Long Tran, Oliver He
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT

measurement date
type: Class
subclass of: measurement time
definition: A date when a measurement is conducted.
definition editor: Long Tran, Oliver He
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT

measurement datetime
type: Class
subclass of: measurement time
definition: A datetime when a measurement is conducted.
definition editor: Long Tran, Oliver He
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT

clnical measurement identifier
type: Class
subclass of: CRID
subclass of: Restriction
  on property: is about
  some values from: care site
definition: A unique key given to a Measurement record for a Person. Such record can be used in the ETL for how duplicate Measurements during the same Visit were handled.
definition editor: Oliver He, Long Tran
alternative term: measurement ID
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT

payer plan
type: Class
subclass of: plan specification
subclass of: personal information
definition: Payer plan is a plan specification that captures the details of the period of time that a person is continuously enrolled under a specific health Plan benefit structure from a given payer. Each person receiving healthcare is typically covered by a health benefit plan, which pays for (fully or partially), or directly provides, the care. These benefit plans are provided by payers, such as health insurances or state or government agencies.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD

payer plan temporal region
type: Class
subclass of: temporal region
definition: A temporal region that is associated with the payment process defined in a payer plan
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD

payer plan period
type: Class
subclass of: payer plan temporal region
definition: A period time of the payment that is covered by a payer plan for a person.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD

payer plan period start date
type: Class
subclass of: payer plan temporal region
definition: A date when a payer plan period starts.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD

payer plan period end date
type: Class
subclass of: payer plan temporal region
definition: A date when a payer plan period ends.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#PAYER_PLAN_PERIOD

medical occurrence
type: Class
subclass of: process
definition: A process that a patient experiences over a period of time.
definition editor: Oliver He, Long Tran
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html

condition occurrence record
type: Class
subclass of: electronic health record
definition: An electronic health record that records the information of medical condition.
definition editor: Long Tran, Oliver He
alternative term: Condition Occurrence Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#CONDITION_OCCURRENCE

electronic health cost record
type: Class
subclass of: electronic health record
definition: An electronic health record that records the information of medical cost.
definition editor: Long Tran, Oliver He
alternative term: Cost Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#COST

electronic death record
type: Class
subclass of: electronic health record
example of usage: As part of the OMOP CDM, use the type concept that be reflects the source of the death record. It is possible that an administrative claims database would source death information from a government file so do not assume the Death Type is the same as the Visit Type, etc.
definition: An electronic health record that records the information of the death record of a person.
definition editor: Long Tran, Oliver He
alternative term: Death Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#DEATH

electronic device record
type: Class
subclass of: electronic health record
definition: An electronic health record that records the information of medical device usage.
definition editor: Long Tran, Oliver He
alternative term: Device Exposure Type Concept
alternative term: Device Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#DEVICE_EXPOSURE

electronic drug record
type: Class
subclass of: electronic health record
example of usage: As part of the OMOP CDM, choose the drug_type_concept_id that best represents the provenance of the record, for example whether it came from a record of a prescription written or physician administered drug.
definition: An electronic health record that records the information of drug usage including drug prescriptions written, prescriptions dispensed, medication history, patient-reported exposure, etc.
definition editor: Long Tran, Oliver He
alternative term: Drug Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#DRUG_EXPOSURE

medical observation data
type: Class
subclass of: data item
definition: A data item that captures clinical facts about a patient obtained in the context of examination, questioning or a procedure.
definition editor: Long Tran, Oliver He
alternative term: medical observation
alternative term: observation
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#OBSERVATION
comment: This term is dervied from OMOP:Observation term. Observations differ from Measurements in that they do not require a standardized test or some other activity to generate clinical fact. Typical observations are medical history, family history, the stated need for certain treatment, social circumstances, lifestyle choices, healthcare utilization patterns, etc.

electronic episode record
type: Class
subclass of: electronic health record
definition: An electronic health record that records the information of medical Episode record.
definition editor: Long Tran, Oliver He
alternative term: Procedure Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#EPISODE

electronic measurement record
type: Class
subclass of: electronic health record
definition: An electronic health record that records the information of medical measurement record.
definition editor: Long Tran, Oliver He
alternative term: Measurement Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#MEASUREMENT

electronic health note record
type: Class
subclass of: electronic health record
example of usage: As part of the OMOP CDM, the provenance of the notes most likely will be EHR.
definition: An electronic health record that records the information of medical notes.
definition editor: Long Tran, Oliver He
alternative term: Note Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#NOTE

electronic health observation record
type: Class
subclass of: electronic health record
definition: An electronic health record that records the information of medical observational record.
definition editor: Long Tran, Oliver He
alternative term: Observation Period Type Concept
alternative term: Observation Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#OBSERVATION

electronic health procedure record
type: Class
subclass of: electronic health record
example of usage: As part of the OMOP CDM, PROCEDURE TYPE CONCEPT best represents the provenance of the record, for example whether it came from an EHR record or billing claim. If a procedure is recorded as an EHR encounter, the PROCEDURE_TYPE_CONCEPT would be ‘EHR encounter record’.
definition: An electronic health record that records the information of Procedure record.
definition editor: Long Tran, Oliver He
alternative term: Procedure Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

electronic specimen record
type: Class
subclass of: electronic health record
definition: An electronic health record that records the information of the specimen record.
definition editor: Long Tran, Oliver He
alternative term: Specimen Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#SPECIMEN

electronic medical visit record
type: Class
subclass of: electronic health record
example of usage: As part of the OMOP CDM, populate this field based on the provenance of the visit record, as in whether it came from an EHR record or billing claim.
definition: An electronic health record that records the information of medical visit.
definition editor: Long Tran, Oliver He
alternative term: Visit Type Concept
definition source: https://ohdsi.github.io/CommonDataModel/cdm54.html#PROCEDURE_OCCURRENCE

preliminary diagnosis
type: Class
subclass of: diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

preliminary admission diagnosis
type: Class
subclass of: preliminary diagnosis
subclass of: admission diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms/32901
definition source: https://athena.ohdsi.org/search-terms/terms

preliminary discharge diagnosis
type: Class
subclass of: preliminary diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms/32901
definition source: https://athena.ohdsi.org/search-terms/terms

primary diagnosis
type: Class
subclass of: diagnosis
definition: The primary diagnosis is a diagnosis of the patient condition that demands the most provider resources during the patient’s stay.
definition editor: Oliver He, Long Tran
alternative term: primary diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms/32902
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://www.definitivehc.com/resources/glossary/primary-diagnosis
comment: There is often confusion surrounding primary and principal diagnoses and, consequently, the terms are commonly used interchangeably. While these can be (and frequently are) the same diagnosis in practice, their definitions are distinct. While a principal diagnosis is the underlying cause of patient symptoms, the primary diagnosis is used for healthcare billing purposes. Reference: https://www.definitivehc.com/resources/glossary/primary-diagnosis

primary admission diagnosis
type: Class
subclass of: primary diagnosis
subclass of: admission diagnosis
definition editor: Oliver He, Long Tran
alternative term: primary admission diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms/32901
definition source: https://athena.ohdsi.org/search-terms/terms

primary discharge diagnosis
type: Class
subclass of: primary diagnosis
subclass of: discharge diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

primary referral diagnosis
type: Class
subclass of: primary diagnosis
subclass of: referral diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

secondary diagnosis
type: Class
subclass of: diagnosis
definition: A secondary diagnosis is a diagnosis made at the time of admission, that develops subsequently, or that affects the treatment received and/or length of stay.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://medcom.uiowa.edu/theloop/announcements/understanding-principal-and-secondary-conditions-2

secondary admission diagnosis
type: Class
subclass of: secondary diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

secondary discharge diagnosis
type: Class
subclass of: secondary diagnosis
subclass of: discharge diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

secondary referral diagnosis
type: Class
subclass of: secondary diagnosis
subclass of: referral diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

admission diagnosis
type: Class
subclass of: diagnosis
definition: An admitting diagnosis is defined as the initial working diagnosis documented by the patient's admitting or attending physician who determined that inpatient care was necessary.
definition editor: Oliver He, Long Tran
alternative term: admission diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://manual.jointcommission.org/releases/TJC2016B/DataElem0540.html#:~:text=Definition%3A&text=The%20admitting%20diagnosis%20is%20defined,that%20inpatient%20care%20was%20necessary.

confirmed diagnosis
type: Class
subclass of: diagnosis
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms

death diagnosis
type: Class
subclass of: diagnosis
definition: The diagnosis of the death of a person
definition editor: Oliver He, Long Tran
alternative term: death diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms/32895
definition source: https://athena.ohdsi.org/search-terms/terms

discharge diagnosis
type: Class
subclass of: diagnosis
definition: A discharge diagnosis is a final diagnosis given a patient before release from the hospital after all testing, surgery, and workup are complete.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://medical-dictionary.thefreedictionary.com/discharge+diagnosis

postoperative diagnosis
type: Class
subclass of: diagnosis
definition: A postoperative diagnosis is a diagnosis or diagnoses discovered or confirmed during the surgery. Often it is the same as the preoperative diagnosis.
definition editor: Oliver He, Long Tran
alternative term: primary admission diagnosis
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85779000#:~:text=Definition%3A,same%20as%20the%20Preoperative%20Diagnosis.

medical exposure
type: Class
subclass of: medical occurrence
definition: A medical occurrence in which a patience is exposed to a medical related material entity such as drug or medical device. Medical exposure refers primarily to exposure incurred by patients for the purpose of medical diagnosis or treatment.
definition editor: Oliver He, Long Tran
definition source: https://www.sciencedirect.com/topics/engineering/medical-exposure

preoperative diagnosis
type: Class
subclass of: diagnosis
definition: A preoperative diagnosis is a surgical diagnosis or diagnoses that are assigned to the patient before the surgical procedure, and is the reason for the surgery. A preoperative diagnosis is, in the opinion of the surgeon, the diagnosis that will be confirmed during surgery.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=85778000#:~:text=Definition%3A,will%20be%20confirmed%20during%20surgery.

referral diagnosis
type: Class
subclass of: diagnosis
definition: A referral is a written request from one health professional to another health professional or health service, asking them to diagnose or treat you for a particular condition.
definition editor: Oliver He, Long Tran
definition source: https://athena.ohdsi.org/search-terms/terms
definition source: https://www.healthdirect.gov.au/what-is-a-referral#:~:text=A%20referral%20is%20a%20written,you%20for%20a%20particular%20condition.

self-replicating nucleic acid
type: Class
subclass of: acellular self-replicating organic structure
definition: An acellular self-replicating organic structure that is composed of nucleic acid
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures

mobile genetic element
type: Class
subclass of: self-replicating nucleic acid
definition: A self-replicating nucleic acid that can move around within a genome, or that can be transferred from one species or replicon to another.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Mobile_genetic_elements
definition source: https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures

plasmid
type: Class
subclass of: mobile genetic element
definition: A mobile genetic element that is composed of a generally circular extrachromosomal DNA molecule and is able to replicate and be transmitted independent of chromosomal DNA.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Mobile_genetic_elements
definition source: https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures

transposon
type: Class
subclass of: mobile genetic element
definition: A mobile genetic element that is composed of a DNA sequence and can move and replicate in different parts of a cell's genome.
definition editor: Oliver He
definition source: https://en.wikipedia.org/wiki/Mobile_genetic_elements
definition source: https://en.wikipedia.org/wiki/Template:Self-replicating_organic_structures

age less than 18 years
type: Class
subclass of: age
subclass of: Restriction
  on property: quality measured by year
  max qualified cardinality: 17
  on data range: integer
definition: A age quality that is measured by the value of less than 18 years old
definition editor: Fred Dowd, Oliver He
alternative term: age less than 18 years old

GFR 30-59 mL/min/1.73m2
type: Class
subclass of: blood glomerular filtration rate

eGFR >=60 mL/min/1.73m2 with urine albumin excretion >= 30 mg/g creatinine
type: Class
subclass of: blood glomerular filtration rate

eGFR >= 60 mL/min/1.73m2 with urine protein excretion >= 150 mg/g creatinine
type: Class
subclass of: blood glomerular filtration rate

medical history information provider role
type: Class
subclass of: health care provider role
definition: A role of a person (e.g., a study participant, participant's family member, or participant's physician) who provides the medical history information.
definition editor: Edison Ong, Oliver He

study participant's family member role
type: Class
subclass of: role in human social processes
definition: A role of a person who is a family member of a participant in an investigation study.
definition editor: Edison Ong, Oliver He

study participant's physician role
type: Class
subclass of: physician role
definition: a role of a physician who takes care of a study participant
definition editor: Edison Ong, Oliver He

age at diagnosis of disease
type: Class
subclass of: age
definition editor: An age when a disease is first diagnosed

age at diagnosis of kidney disease
type: Class
subclass of: age at diagnosis of disease

Whether chronic kidney disease
type: Class
subclass of: Whether kidney diseased
subclass of: Restriction
  on property: is about
  some values from: chronic kidney disease

Whether acute kidney injury
type: Class
subclass of: Whether kidney diseased
subclass of: Restriction
  on property: is about
  some values from: acute kidney failure

time of biopsy
type: Class
subclass of: zero-dimensional temporal region

year of kidney biopsy
type: Class
subclass of: time of kidney biopsy

time of kidney biopsy
type: Class
subclass of: time of biopsy

month of kidney biopsy
type: Class
subclass of: time of kidney biopsy

age at the start of kidney stone
type: Class
subclass of: age at the start of disease

age at the start of disease
type: Class
subclass of: age
definition: An age when a disease started in a patient

Whether diabetes
type: Class
subclass of: Whether diseased

age at diagosis of diabetes
type: Class
subclass of: age at diagnosis of disease

What disease
type: Class
subclass of: patient condition question

What type of diabetes
type: Class
subclass of: What disease

treatment question
type: Class
subclass of: textual question

medicatoin treatment question
type: Class
subclass of: treatment question

surgical treatment question
type: Class
subclass of: treatment question

Whether taking medication for diabetes
type: Class
subclass of: medicatoin treatment question

age at the start of medication
type: Class
subclass of: age
definition: An age when a medication is first used

age at the start of taking medication for diabetes
type: Class
subclass of: age at the start of medication

What medication
type: Class
subclass of: medicatoin treatment question

What medication taken for diabetes
type: Class
subclass of: What medication

Whether insulin taken for diabetes
type: Class
subclass of: What medication taken for diabetes

Whether diabetes during pregnancy
type: Class
subclass of: pregnancy question
subclass of: Whether diabetes

clinical trial
type: Class
subclass of: human subject study
definition: a clinical trial is a medical interventional study where participants are assigned prospectively to an intervention or interventions according to a protocol to evaluate the safety and efficacy of the intervention(s) on biomedical or other health related outcomes. The Interventions include but are not restricted to drugs, cells and other biological products, surgical procedures, radiologic procedures, devices, behavioral treatments, process-of-care changes, preventive care, etc.
definition editor: Oliver He, Asiyah Yu Lin, Qingliang Li
alternative term: interventional trial
definition source: https://clinicaltrials.gov/ct2/search/map
definition source: https://en.wikipedia.org/wiki/Clinical_trial
definition source: https://prsinfo.clinicaltrials.gov/definitions.html
definition source: https://www.who.int/ictrp/en/

Early Phase 1 clinical trial
type: Class
equivalent class: Restriction
  on property: has process quality
  some values from: clinical trial early phase 1
subclass of: clinical trial
definition: A clinical trial that is at Early Phase 1 or Phase 0
definition: A clinical trial that is at an Early Phase i or Phase 0, which is designed to use an investigational agent that is available only in very limited quantities and which has never previously given to humans or for which there is extremely limited human experience. Phase 0 clinical trials are intended to enable researchers to understand the path of the drug in the body and its efficacy. Adverse event reporting in Phase 0 trials is expedited. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase 0 clinical trial
alternative term: Phase 0 trial
alternative term: Pre-Clinical Trial
definition source: http://purl.obolibrary.org/obo/NCIT_C54721
definition source: https://en.wikipedia.org/wiki/Clinical_trial

Phase 1 clinical trial
type: Class
equivalent class: Restriction
  on property: has process quality
  some values from: clinical trial phase 1
subclass of: clinical trial
subclass of: Restriction
  on property: has process quality
  some values from: clinical trial phase 1
definition: A clinical trial that is at Phase 1, which is often the first-in-man trial, and it tests within a small group of people (typically 20-80) to evaluate safety, determine safe dosage ranges, and begin to identify side effects. A drug's side effects could be subtle or long term, or may only happen with a few people, so phase 1 trials are not expected to identify all side effects.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase 1 trial
alternative term: Phase I clinical trial
alternative term: clinical trial for safety screening
definition source: http://purl.obolibrary.org/obo/NCIT_C15600
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0920321
NCIT code: C15600

Phase 2 clinical trial
type: Class
equivalent class: Restriction
  on property: has process quality
  some values from: clinical trial phase 2
subclass of: clinical trial
definition: A clinical trial that is at Phase 2, which is designed to study a biomedical or behavioral intervention in a larger group of people (several hundred), to evaluate the drug's effectiveness for a particular indication in patients with the disease or condition under study, and to determine the common short-term side effects and risks associated with the intervention. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase 2 trial
alternative term: Phase II clinical trial
alternative term: Phase II trial
definition source: http://purl.obolibrary.org/obo/NCIT_C15601
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0282460
NCIT code: C15601

Phase 3 clinical trial
type: Class
equivalent class: Restriction
  on property: has process quality
  some values from: clinical trial phase 3
subclass of: clinical trial
definition: A clinical trial that is at Phase 3
definition: A clinical trial that is at Phase 3, which is designed to investigate the efficacy of the biomedical or behavioral intervention in large groups of human subjects (from several hundred to several thousand), to confirm efficacy, to monitor adverse reactions to the new medication or treatment regimen with respect to long-term use and by comparing the intervention to other standard or experimental interventions as well as to a placebo. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase III trial
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0282461
NCIT code: C15602

Phase 4 clinical trial
type: Class
equivalent class: Restriction
  on property: has process quality
  some values from: clinical trial phase 4
subclass of: clinical trial
definition: A clinical trial that is at Phase 4
definition editor: Leon Li, Asiyah Lin, Oliver He
definition source: https://en.wikipedia.org/wiki/Clinical_trial
UMLS_CUI: C0282462
NCIT code: C15603

quality
type: Class
subclass of: specifically dependent continuant
definition: A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
imported from: envo.owl
OBO foundry unique label: quality (PATO)
has exact synonym: trait

age
type: Class
subclass of: physical quality
definition: A time quality inhering in a bearer by virtue of how long the bearer has existed.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000011
in subset: attribute slim
in subset: scalar slim

biological sex
type: Class
subclass of: physical object quality
definition: An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved.
definition: 患者生理性别在特定编码体系中的代码 @zh
definition editor: Suyuan Peng, Hong Yu, Yongqun He
definition source: 《电子病历基本数据集 第10部分：住院病案首页》WS 445.10-2014 @zh
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000047
in subset: attribute slim

height
type: Class
subclass of: physical object quality
definition: A 1-D extent quality inhering in a bearer by virtue of the bearer's vertical dimension of extension.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000119
in subset: attribute slim
in subset: scalar slim

weight
type: Class
subclass of: physical quality
definition: A physical quality inhering in a bearer that has mass near a gravitational body.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000128
in subset: attribute slim
in subset: scalar slim

position
type: Class
subclass of: physical quality
definition: A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.
imported from: envo.owl
has exact synonym: location
has exact synonym: placement
has exact synonym: relational spatial quality

behavioral quality
type: Class
subclass of: organismal quality
definition: An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation.
imported from: oae.owl
imported from: pato.owl
has_alternative_id: PATO:0001722
has exact synonym: behavioural quality
has_obo_namespace: quality
id: PATO:0000186

female
type: Class
subclass of: phenotypic sex
definition: A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000383
in subset: mpath slim
in subset: value slim

male
type: Class
subclass of: phenotypic sex
definition: A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000384
in subset: mpath slim
in subset: value slim

physical quality
type: Class
subclass of: physical object quality
definition: A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
imported from: envo.owl
imported from: pato.owl
has_alternative_id: PATO:0002079
database_cross_reference: Wikipedia:Physical_property
has exact synonym: relational physical quality
has_obo_namespace: quality
id: PATO:0001018
in subset: attribute slim

process quality
type: Class
subclass of: quality
definition: A quality which inheres in an process.
imported from: oae.owl
imported from: pato.owl
has_alternative_id: PATO:0001239
has_alternative_id: PATO:0001240
has exact synonym: quality of a process
has exact synonym: quality of occurrent
has exact synonym: quality of process
has exact synonym: relational quality of occurrent
has_obo_namespace: quality
id: PATO:0001236
comment: See comments of relational quality of a physical entity.

physical object quality
type: Class
subclass of: quality
definition: A quality which inheres in a continuant.
imported from: envo.owl
imported from: oae.owl
imported from: pato.owl
has_alternative_id: PATO:0001237
has_alternative_id: PATO:0001238
database_cross_reference: snap:Quality
has exact synonym: monadic quality of a continuant
has exact synonym: multiply inhering quality of a physical entity
has exact synonym: quality of a continuant
has exact synonym: quality of a single physical entity
has exact synonym: quality of an object
has exact synonym: quality of continuant
has_narrow_synonym: monadic quality of an object
has_narrow_synonym: monadic quality of continuant
has_obo_namespace: quality
id: PATO:0001241
comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.

phenotypic sex
type: Class
subclass of: biological sex
definition: An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0001894
in subset: attribute slim

organismal quality
type: Class
subclass of: physical object quality
definition: A quality that inheres in an entire organism or part of an organism.
imported from: oae.owl
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0001995

displaced
type: Class
subclass of: position
definition: A positional quality inhering in a bearer by virtue the bearer's being changed in position.
imported from: envo.owl

collection of organisms
type: Class
subclass of: object aggregate
subclass of: material entity
subclass of: organismal entity
definition: A material entity that consists of two or more organisms, viruses, or viroids.
imported from: envo.owl

ecological community
type: Class
subclass of: community
subclass of: multi-species collection of organisms
definition: A community of at least two different species, living in a particular area. Must have at least two populations of different species as members.
imported from: envo.owl
in subset: envoPolar

community
type: Class
subclass of: collection of organisms
definition: A collection of organisms of the same species whose members are all either genealogically related to each other or have mated with each other.
imported from: envo.owl

multi-species collection of organisms
type: Class
subclass of: collection of organisms
definition: A collection of organisms that consists of two or more organisms from at least two species.
imported from: envo.owl

organismal entity
type: Class
equivalent class: Class
  union of: organism or virus or viroid
  union of: collection of organisms
subclass of: material entity
definition: A material entity that is one or more organisms, viruses or viroids.
imported from: envo.owl

plant anatomical entity
type: Class
subclass of: material entity
definition: An anatomical entity that is or was part of a plant.
imported from: envo.owl
has exact synonym: entidad anat&#243mica vegetal (Spanish, exact)
has exact synonym: 植物 解剖学（形態）的実体 (Japanese, exact)

protein
type: Class
subclass of: peptide
editor preferred label: protein
example of usage: antithrombin III is a protein
definition: An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
imported from: Ontology for Biomedical Investigations
imported from: pr.owl

system
type: Class
subclass of: material entity
definition: A material entity consisting of multiple components that are causally integrated.
editor note: May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43
definition editor: Chris Mungall
definition source: http://www.jbiomedsem.com/content/4/1/43
imported from: envo.owl

region
type: Class
subclass of: generically dependent continuant
editor preferred label: region
definition: A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids.
alternative term: primary structure of sequence macromolecule
alternative term: sequence
imported from: Ontology for Biomedical Investigations
imported from: so.owl

zone of skin
type: Class
subclass of: ectoderm-derived structure
subclass of: zone of organ
subclass of: Restriction
  on property: part of
  some values from: skin of body
subclass of: Restriction
  on property: has part
  some values from: skin epidermis
subclass of: Restriction
  on property: has part
  some values from: dermis
definition: Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.
curator note: Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee
imported from: oae.owl
imported from: uberon.owl
homology_notes: (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]
external_ontology_notes: we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive
database_cross_reference: Skin
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/20795001
database_cross_reference: EHDAA2:0001844
database_cross_reference: EHDAA:6530
database_cross_reference: EMAPA:17525
database_cross_reference: EV:0100152
database_cross_reference: FMA:86166
database_cross_reference: GAID:933
database_cross_reference: MA:0000151
database_cross_reference: MAT:0000284
database_cross_reference: MESH:D012867
database_cross_reference: MIAA:0000284
database_cross_reference: OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA
database_cross_reference: VHOG:0000860
has exact synonym: portion of skin
has exact synonym: region of skin
has exact synonym: skin
has exact synonym: skin region
has exact synonym: skin zone
has_obo_namespace: uberon
id: UBERON:0000014
in subset: pheno slim

anatomical boundary
type: Class
subclass of: immaterial anatomical entity
definition: A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO:0000192
database_cross_reference: CARO:0000010
database_cross_reference: FMA:50705
has_obo_namespace: uberon
id: UBERON:0000015
in subset: upper level
comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms.

tube
type: Class
subclass of: anatomical conduit
subclass of: Restriction
  on property: has part
  some values from: subdivision of tube
definition: Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.
curator note: not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts)
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: tubular
database_cross_reference: galen:Tube
has exact synonym: anatomical tube
has_narrow_synonym: duct
has_obo_namespace: uberon
id: UBERON:0000025

appendage
type: Class
subclass of: organism subdivision
definition: Major subdivision of an organism that protrudes from the body[DOS, CARO].
imported from: oae.owl
imported from: uberon.owl
external_definition: An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018].
external_definition: Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736].
has_relational_adjective: appendicular
taxon_notes: this is currently a subtype of organism subdivision - which would exclude feathers
spatially disjoint from: main body axis
database_cross_reference: Appendage
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0598782
database_cross_reference: C61460
database_cross_reference: AEO:0000193
database_cross_reference: BILA:0000018
database_cross_reference: BTO:0001492
database_cross_reference: CARO:0010003
database_cross_reference: EFO:0000799
database_cross_reference: EHDAA2:0003193
database_cross_reference: EV:0100155
database_cross_reference: FBbt:00007000
database_cross_reference: HAO:0000144
database_cross_reference: MAT:0000023
database_cross_reference: MESH:D005121
database_cross_reference: MIAA:0000023
database_cross_reference: OpenCyc:Mx4rvViC-JwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0598782
database_cross_reference: VSAO:0000075
database_cross_reference: XAO:0000218
has_obo_namespace: uberon
has_related_synonym: appendages
has_related_synonym: extremitaet
has_related_synonym: extremity
has_related_synonym: limbs/digits/tail
id: UBERON:0000026
in subset: uberon slim
in subset: efo slim
in subset: pheno slim

head
type: Class
subclass of: subdivision of organism along main body axis
subclass of: Restriction
  on property: part of
  some values from: anterior region of body
subclass of: Restriction
  on property: part of
  some values from: craniocervical region
definition: The head is the anterior-most division of the body [GO].
imported from: oae.owl
imported from: uberon.owl
external_definition: Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO]
external_definition: Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO]
homology_notes: Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG]
spatially disjoint from: heart
database_cross_reference: Head
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0018670
database_cross_reference: C12419
database_cross_reference: birnlex 1230
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302548004
database_cross_reference: AAO:0010335
database_cross_reference: AEO:0000106
database_cross_reference: BILA:0000115
database_cross_reference: BTO:0000282
database_cross_reference: CALOHA:TS-0436
database_cross_reference: EFO:0000964
database_cross_reference: EHDAA2:0003106
database_cross_reference: EMAPA:31858
database_cross_reference: FBbt:00000004
database_cross_reference: FMA:7154
database_cross_reference: GAID:61
database_cross_reference: HAO:0000397
database_cross_reference: MA:0000023
database_cross_reference: MAT:0000294
database_cross_reference: MESH:D006257
database_cross_reference: MIAA:0000294
database_cross_reference: OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg
database_cross_reference: OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA
database_cross_reference: SPD:0000016
database_cross_reference: TAO:0001114
database_cross_reference: TGMA:0000002
database_cross_reference: UMLS:C0018670
database_cross_reference: VHOG:0001644
database_cross_reference: WBbt:0005739
database_cross_reference: XAO:0003024
database_cross_reference: ZFA:0001114
database_cross_reference: galen:Head
has exact synonym: head (volume)
has_narrow_synonym: adult head
has_obo_namespace: uberon
has_related_synonym: cephalic area
id: UBERON:0000033
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

serous membrane
type: Class
subclass of: multi-tissue structure
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: anatomical wall
subclass of: Restriction
  on property: has part
  some values from: mesothelium
subclass of: Restriction
  on property: has part
  some values from: connective tissue
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
definition: multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.
imported from: oae.owl
imported from: uberon.owl
external_definition: A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]
external_definition: a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]
external_ontology_notes: in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA.
Contributor: cmungall
database_cross_reference: Serous membrane
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0036760
database_cross_reference: C13169
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362878009
database_cross_reference: FMA:9581
database_cross_reference: GAID:19
database_cross_reference: MESH:D012704
database_cross_reference: TAO:0005425
database_cross_reference: UMLS:C0036760
database_cross_reference: ZFA:0005425
has exact synonym: tunica serosa
has exact synonym: wall of serous sac
has_obo_namespace: uberon
has_related_synonym: serosa
id: UBERON:0000042
in subset: uberon slim
in subset: vertebrate core

vessel
type: Class
subclass of: anatomical conduit
subclass of: Restriction
  on property: channel for
  some values from: bodily fluid
definition: A tubular structure that contains, conveys body fluid, such as blood or lymph.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0000055
in subset: grouping class
in subset: pheno slim

duct
type: Class
subclass of: organ subunit
subclass of: Restriction
  on property: has part
  some values from: anatomical conduit space
subclass of: Restriction
  on property: has part
  some values from: epithelial layer of duct
subclass of: Restriction
  on property: conduit for
  some values from: organism substance
definition: A tubular structure that transports secreted or excreted substances.
imported from: oae.owl
imported from: uberon.owl
external_definition: A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171].
external_ontology_notes: Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here.
database_cross_reference: Duct (anatomy)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0687028
database_cross_reference: C12948
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91726008
database_cross_reference: AAO:0011123
database_cross_reference: FBbt:00100314
database_cross_reference: FMA:30320
database_cross_reference: TAO:0005171
database_cross_reference: UMLS:C0687028
database_cross_reference: XAO:0004000
database_cross_reference: ZFA:0005171
database_cross_reference: galen:Duct
has exact synonym: anatomical duct
has_narrow_synonym: exocrine duct
has_narrow_synonym: exocrine gland duct
has_obo_namespace: uberon
has_related_synonym: ducts
id: UBERON:0000058
in subset: vertebrate core
in subset: grouping class

anatomical wall
type: Class
subclass of: organ part
subclass of: Restriction
  on property: has part
  some values from: organ component layer
subclass of: Restriction
  on property: adjacent_to
  some values from: anatomical cavity
definition: Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: in FMA, serosa is a wall
has_alternative_id: UBERON:0009915
has_broad_synonym: wall
database_cross_reference: EMAPA:25036
database_cross_reference: FMA:82482
database_cross_reference: galen:Wall
has exact synonym: wall of organ
has_obo_namespace: uberon
has_related_synonym: organ wall
id: UBERON:0000060
in subset: upper level

anatomical structure
type: Class
subclass of: material anatomical entity
subclass of: Restriction
  on property: existence starts during or after
  some values from: zygote stage
subclass of: Restriction
  on property: existence ends during or before
  some values from: death stage
definition: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AnatomicalStructure
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362889002
database_cross_reference: AAO:0010825
database_cross_reference: AEO:0000003
database_cross_reference: BILA:0000003
database_cross_reference: CARO:0000003
database_cross_reference: EHDAA2:0003003
database_cross_reference: EMAPA:0
database_cross_reference: FBbt:00007001
database_cross_reference: FMA:67135
database_cross_reference: GAID:781
database_cross_reference: HAO:0000003
database_cross_reference: MA:0003000
database_cross_reference: MESH:D000825
database_cross_reference: TAO:0000037
database_cross_reference: TGMA:0001823
database_cross_reference: VHOG:0001759
database_cross_reference: WBbt:0000100
database_cross_reference: XAO:0003000
database_cross_reference: ZFA:0000037
has exact synonym: biological structure
has exact synonym: connected biological structure
has_obo_namespace: uberon
id: UBERON:0000061
in subset: upper level

organ
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: anatomical system
subclass of: Restriction
  on property: has boundary
  some values from: anatomical surface
subclass of: Restriction
  on property: existence starts during or after
  some values from: organogenesis stage
definition: Anatomical structure that performs a specific function or group of functions [WP].
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon_110815
external_definition: Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
external_ontology_notes: CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4
database_cross_reference: Organ (anatomy)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0178784
database_cross_reference: C13018
database_cross_reference: birnlex 4
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/272625005
database_cross_reference: CARO:0020004
database_cross_reference: EFO:0000634
database_cross_reference: EMAPA:35949
database_cross_reference: ENVO:01000162
database_cross_reference: FMA:67498
database_cross_reference: MA:0003001
database_cross_reference: OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA
database_cross_reference: OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0178784
database_cross_reference: WBbt:0003760
has_obo_namespace: uberon
has_related_synonym: anatomical unit
has_related_synonym: body organ
has_related_synonym: element
id: UBERON:0000062
in subset: upper level

organ subunit
type: Class
subclass of: organ part
definition: A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.
editor note: FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction
imported from: oae.owl
imported from: uberon.owl
external_definition: Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball.
external_definition: Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal.
database_cross_reference: FMA:86140
has_obo_namespace: uberon
has_related_synonym: organ region with fixed fiat boundary
has_related_synonym: organ segment
has_related_synonym: segment of organ
id: UBERON:0000063
in subset: upper level

organ part
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: organ
definition: A multicellular structure that is a part of an organ.
curator note: currently defined in a very broad sense, may be replaced by more specific classes in the future
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: birnlex 16
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/113343008
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91717005
database_cross_reference: AAO:0011124
database_cross_reference: EFO:0000635
database_cross_reference: FMA:82472
has exact synonym: cardinal organ part
has_obo_namespace: uberon
has_related_synonym: regional part of organ
id: UBERON:0000064
in subset: disjointness axiom removed
in subset: upper level
in subset: efo slim
in subset: non informative

fully formed stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: post-embryonic stage
subclass of: Restriction
  on property: preceded_by
  some values from: organogenesis stage
subclass of: Restriction
  on property: precedes
  some values from: death stage
definition: The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: adult stage
database_cross_reference: BTO:0001043
database_cross_reference: BilaDO:0000004
database_cross_reference: EFO:0001272
database_cross_reference: FBdv:00005369
database_cross_reference: WBls:0000041
database_cross_reference: XtroDO:0000084
has exact synonym: fully formed animal stage
has exact synonym: juvenile-adult stage
has_obo_namespace: uberon
id: UBERON:0000066
in subset: efo slim

embryo stage part
type: Class
equivalent class: Class
  intersection of: life cycle stage
  intersection of: Restriction
    on property: part of
    some values from: embryo stage
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: embryo stage
definition: A stage that is part of the embryo stage.
imported from: oae.owl
imported from: uberon.owl
has exact synonym: embryonic stage part
has_obo_namespace: uberon
id: UBERON:0000067
in subset: grouping class

embryo stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: life cycle
subclass of: Restriction
  on property: precedes
  some values from: fully formed stage
subclass of: Restriction
  on property: precedes
  some values from: post-embryonic stage
definition: A life cycle stage that starts with fertilization and ends with the fully formed embryo.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/296280003
database_cross_reference: BilaDO:0000002
database_cross_reference: EV:0300001
database_cross_reference: FBdv:00005289
database_cross_reference: FMA:72652
database_cross_reference: HsapDv:0000002
database_cross_reference: MmusDv:0000002
database_cross_reference: OGES:000000
database_cross_reference: OGES:000022
database_cross_reference: WBls:0000003
database_cross_reference: WBls:0000092
database_cross_reference: WBls:0000102
database_cross_reference: XAO:1000012
has exact synonym: embryonic stage
has_obo_namespace: uberon
has_related_synonym: embryogenesis
id: UBERON:0000068

death stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: life cycle
subclass of: Restriction
  on property: ends
  some values from: life cycle
definition: End of the life of an organism.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: ncit:Death is an outcome
database_cross_reference: XAO:0000437
database_cross_reference: XtroDO:0000085
has_obo_namespace: uberon
has_related_synonym: death
id: UBERON:0000071

subdivision of skeletal system
type: Class
subclass of: organ system subdivision
subclass of: Restriction
  on property: part of
  some values from: skeletal system
subclass of: Restriction
  on property: composed primarily of
  some values from: skeletal element
definition: Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: UBERON:0010322
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1519343
database_cross_reference: C34076
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/118966000
database_cross_reference: FMA:85544
database_cross_reference: UMLS:C1519343
database_cross_reference: galen:ComplexSkeletalStructure
has exact synonym: skeletal system subdivision
has_obo_namespace: uberon
has_related_synonym: skeletal system part
id: UBERON:0000075
in subset: non informative

external ectoderm
type: Class
subclass of: unilaminar epithelium
subclass of: embryonic tissue
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: part of
  some values from: ectoderm
definition: The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.
editor note: merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)
imported from: oae.owl
imported from: uberon.owl
development_notes: (or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis
database_cross_reference: External ectoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1515087
database_cross_reference: C34309
database_cross_reference: EHDAA2:0001968
database_cross_reference: EHDAA:1494
database_cross_reference: EHDAA:350
database_cross_reference: EHDAA:4784
database_cross_reference: EHDAA:4790
database_cross_reference: EHDAA:4796
database_cross_reference: EHDAA:7860
database_cross_reference: EMAPA:16096
database_cross_reference: FMA:87656
database_cross_reference: UMLS:C1515087
has exact synonym: surface (external) ectoderm
has exact synonym: surface ectoderm
has_obo_namespace: uberon
id: UBERON:0000076
in subset: pheno slim

post-embryonic stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: life cycle
subclass of: Restriction
  on property: preceded_by
  some values from: embryo stage
definition: stage succeeding embryo, including mature structure
imported from: oae.owl
imported from: uberon.owl
taxon_notes: In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997)
database_cross_reference: BilaDO:0000003
database_cross_reference: OGES:000010
database_cross_reference: OGES:000014
database_cross_reference: OGES:000024
database_cross_reference: WBls:0000022
database_cross_reference: WBls:0000093
database_cross_reference: WBls:0000103
has exact synonym: postembryonic stage
has_narrow_synonym: post-hatching stage
has_obo_namespace: uberon
has_related_synonym: postembryonic
id: UBERON:0000092

membrane organ
type: Class
subclass of: organ
subclass of: Restriction
  on property: composed primarily of
  some values from: dense connective tissue
definition: Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]
imported from: oae.owl
imported from: uberon.owl
created by: cjm
creation date: 2009-07-30T05:19:13Z
has_broad_synonym: membrane
database_cross_reference: FMA:7145
has exact synonym: membrane of organ
has_obo_namespace: uberon
id: UBERON:0000094

life cycle
type: Class
subclass of: process
subclass of: Restriction
  on property: has part
  some values from: life cycle stage
subclass of: Restriction
  on property: starts with
  some values from: zygote stage
subclass of: Restriction
  on property: ends with
  some values from: death stage
definition: An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FBdv:00000000
database_cross_reference: HsapDv:0000001
database_cross_reference: MmusDv:0000001
database_cross_reference: OGES:000011
database_cross_reference: ncithesaurus:Life
has exact synonym: entire life cycle
has exact synonym: entire lifespan
has exact synonym: life
has exact synonym: lifespan
has_obo_namespace: uberon
id: UBERON:0000104
in subset: upper level

life cycle stage
type: Class
subclass of: process
subclass of: Restriction
  on property: part of
  some values from: life cycle
definition: A spatiotemporal region encompassing some part of the life cycle of an organism.
editor note: this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: the WBls class 'all stages' belongs here as it is the superclass of other WBls stages
external_ontology_notes: we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage
database_cross_reference: BILS:0000105
database_cross_reference: EFO:0000399
database_cross_reference: FBdv:00007012
database_cross_reference: FMA:24120
database_cross_reference: HsapDv:0000000
database_cross_reference: MmusDv:0000000
database_cross_reference: OlatDv:0000010
database_cross_reference: PdumDv:0000090
database_cross_reference: WBls:0000002
database_cross_reference: XAO:1000000
database_cross_reference: ZFS:0000000
database_cross_reference: ZFS:0100000
database_cross_reference: ncithesaurus:Developmental_Stage
has_narrow_synonym: developmental stage
has_narrow_synonym: stage
has_obo_namespace: uberon
id: UBERON:0000105
in subset: upper level
in subset: efo slim

zygote stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: part of
  some values from: embryo stage
subclass of: Restriction
  on property: starts
  some values from: life cycle
definition: A stage at which the organism is a single cell produced by means of sexual reproduction.
imported from: oae.owl
imported from: uberon.owl
homology_notes: As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]
database_cross_reference: Zygote
database_cross_reference: C12601
database_cross_reference: BILS:0000106
database_cross_reference: BilaDO:0000005
database_cross_reference: EFO:0001322
database_cross_reference: EHDAA:27
database_cross_reference: EMAPA:16033
database_cross_reference: FBdv:00005288
database_cross_reference: PdumDv:0000100
database_cross_reference: VHOG:0000745
database_cross_reference: XAO:1000001
database_cross_reference: ZFS:0000001
has exact synonym: 1-cell stage
has exact synonym: fertilized egg stage
has exact synonym: one cell stage
has_obo_namespace: uberon
has_related_synonym: fertilized egg stage
has_related_synonym: one-cell stage
has_related_synonym: zygote
has_related_synonym: zygotum
id: UBERON:0000106
in subset: efo slim

cleavage stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: part of
  some values from: embryo stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: zygote stage
definition: The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Cleavage (embryo)
database_cross_reference: BILS:0000107
database_cross_reference: BilaDO:0000006
database_cross_reference: EFO:0001290
database_cross_reference: FBdv:00000054
database_cross_reference: MESH:A16.254.270
database_cross_reference: MmusDv:0000004
database_cross_reference: OGES:000015
database_cross_reference: OGES:000020
database_cross_reference: PdumDv:0000200
database_cross_reference: XAO:1000004
database_cross_reference: ZFS:0000046
has_obo_namespace: uberon
id: UBERON:0000107
in subset: efo slim

blastula stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: part of
  some values from: embryo stage
subclass of: Restriction
  on property: preceded_by
  some values from: cleavage stage
definition: An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
editor note: consider adding a preceding stage 'morula stage' as part of cleavage
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Blastula
database_cross_reference: BILS:0000108
database_cross_reference: BilaDO:0000007
database_cross_reference: EFO:0001282
database_cross_reference: HsapDv:0000006
database_cross_reference: MmusDv:0000007
database_cross_reference: OGES:000003
database_cross_reference: OGES:000016
database_cross_reference: OGES:000021
database_cross_reference: OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg
database_cross_reference: WBls:0000005
database_cross_reference: XAO:1000003
database_cross_reference: ZFS:0000045
has_obo_namespace: uberon
id: UBERON:0000108
in subset: efo slim

gastrula stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: part of
  some values from: embryo stage
subclass of: Restriction
  on property: preceded_by
  some values from: blastula stage
definition: A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BILS:0000109
database_cross_reference: BilaDO:0000008
database_cross_reference: EFO:0001296
database_cross_reference: FBdv:00005317
database_cross_reference: HsapDv:0000010
database_cross_reference: MmusDv:0000013
database_cross_reference: OGES:000004
database_cross_reference: OGES:000019
database_cross_reference: WBls:0000010
database_cross_reference: XAO:1000005
database_cross_reference: ZFS:0000047
has_obo_namespace: uberon
has_related_synonym: blastocystis trilaminaris stage
has_related_synonym: trilaminar blastocyst stage
has_related_synonym: trilaminar blastoderm stage
has_related_synonym: trilaminar disk stage
has_related_synonym: trilaminar germ stage
has_related_synonym: trilaminar stage
id: UBERON:0000109
in subset: efo slim

neurula stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: part of
  some values from: embryo stage
subclass of: Restriction
  on property: preceded_by
  some values from: gastrula stage
definition: Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BILS:0000110
database_cross_reference: BilaDO:0000009
database_cross_reference: HsapDv:0000012
database_cross_reference: MmusDv:0000017
database_cross_reference: XAO:1000006
has_obo_namespace: uberon
id: UBERON:0000110

organogenesis stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: part of
  some values from: embryo stage
subclass of: Restriction
  on property: preceded_by
  some values from: neurula stage
definition: A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Organogenesis
database_cross_reference: BILS:0000111
database_cross_reference: BilaDO:0000010
database_cross_reference: HsapDv:0000015
database_cross_reference: MmusDv:0000018
database_cross_reference: OGES:000005
database_cross_reference: OGES:000032
has_obo_namespace: uberon
has_related_synonym: segmentation stage
id: UBERON:0000111

sexually immature stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: fully formed stage
imported from: oae.owl
imported from: uberon.owl
external_definition: The stage of being a sexually immature adult animal[XAO:1000010].
taxon_notes: In mammals this would include infant (nourishment from lactation) and juvenile (prepubertal no longer dependent on mother)
database_cross_reference: BILS:0000112
database_cross_reference: BTO:0002168
database_cross_reference: EFO:0001300
database_cross_reference: EV:0300051
database_cross_reference: MmusDv:0000043
database_cross_reference: OGES:000009
database_cross_reference: XAO:1000010
database_cross_reference: XtroDO:0000083
database_cross_reference: ZFS:0000051
has exact synonym: immature stage
has_narrow_synonym: juvenile stage
has_obo_namespace: uberon
has_related_synonym: subadult stage
id: UBERON:0000112
in subset: efo slim

anterior region of body
type: Class
subclass of: organism subdivision
subclass of: Restriction
  on property: anterior_to
  some values from: posterior region of body
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0000153

posterior region of body
type: Class
subclass of: organism subdivision
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0000154

mouth
type: Class
equivalent class: Class
  intersection of: subdivision of digestive tract
  intersection of: Restriction
    on property: proximalmost_part_of
    some values from: digestive tract
subclass of: subdivision of digestive tract
subclass of: Restriction
  on property: part of
  some values from: head
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: part of
    some values from: respiratory system
subclass of: Restriction
  on property: proximalmost_part_of
  some values from: digestive tract
subclass of: Restriction
  on property: develops_from
  some values from: future mouth
definition: The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).
imported from: oae.owl
imported from: uberon.owl
external_definition: Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]
homology_notes: Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]
has_relational_adjective: oral
development_notes: some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives
external_ontology_notes: in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips
database_cross_reference: Mouth
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/21082005
database_cross_reference: AAO:0010355
database_cross_reference: BTO:0001090
database_cross_reference: BTO:0004698
database_cross_reference: CALOHA:TS-1315
database_cross_reference: EFO:0000825
database_cross_reference: EHDAA2:0001326
database_cross_reference: EHDAA:542
database_cross_reference: EMAPA:16262
database_cross_reference: FBbt:00003126
database_cross_reference: FMA:49184
database_cross_reference: GAID:75
database_cross_reference: MA:0000341
database_cross_reference: MA:0002474
database_cross_reference: MAT:0000038
database_cross_reference: MESH:D009055
database_cross_reference: MIAA:0000038
database_cross_reference: OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA
database_cross_reference: TADS:0000040
database_cross_reference: TAO:0000547
database_cross_reference: TAO:0000590
database_cross_reference: TGMA:0000131
database_cross_reference: VHOG:0000280
database_cross_reference: VHOG:0000812
database_cross_reference: XAO:0003029
database_cross_reference: ZFA:0000547
database_cross_reference: ZFA:0000590
database_cross_reference: galen:Mouth
has exact synonym: regio oralis
has_narrow_synonym: adult mouth
has_obo_namespace: uberon
has_related_synonym: cavital oralis
has_related_synonym: cavitas oris
has_related_synonym: cavum oris
has_related_synonym: mouth cavity
has_related_synonym: oral region
has_related_synonym: oral vestibule
has_related_synonym: rima oris
has_related_synonym: stoma
has_related_synonym: stomatodaeum
has_related_synonym: trophic apparatus
has_related_synonym: vestibule of mouth
has_related_synonym: vestibulum oris
id: UBERON:0000165
in subset: major organ
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

blood
type: Class
subclass of: haemolymphatic fluid
subclass of: Restriction
  on property: part of
  some values from: hematopoietic system
subclass of: Restriction
  on property: part of
  some values from: cardiovascular system
subclass of: Restriction
  on property: has part
  some values from: blood plasma
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive blood
definition: A fluid that is composed of blood plasma and erythrocytes.
curator note: This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
imported from: oae.owl
imported from: uberon.owl
external_definition: A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]
external_definition: Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]
axiom_lost_from_external_ontology: relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]
homology_notes: Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]
Contributor: cmungall
Contributor: tmeehan
database_cross_reference: Blood
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0005767
database_cross_reference: C12434
database_cross_reference: AAO:0000046
database_cross_reference: BTO:0000089
database_cross_reference: CALOHA:TS-0079
database_cross_reference: EFO:0000296
database_cross_reference: EHDAA2:0000176
database_cross_reference: EHDAA:418
database_cross_reference: EMAPA:16332
database_cross_reference: ENVO:02000027
database_cross_reference: EV:0100047
database_cross_reference: FMA:9670
database_cross_reference: GAID:965
database_cross_reference: MA:0000059
database_cross_reference: MESH:D001769
database_cross_reference: MIAA:0000315
database_cross_reference: OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000007
database_cross_reference: UMLS:C0005767
database_cross_reference: VHOG:0000224
database_cross_reference: XAO:0000124
database_cross_reference: ZFA:0000007
database_cross_reference: galen:Blood
has exact synonym: portion of blood
has exact synonym: vertebrate blood
has_obo_namespace: uberon
has_related_synonym: whole blood
id: UBERON:0000178
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

haemolymphatic fluid
type: Class
equivalent class: Class
  intersection of: organism substance
  intersection of: Restriction
    on property: part of
    some values from: hemolymphoid system
subclass of: bodily fluid
subclass of: Restriction
  on property: part of
  some values from: hemolymphoid system
definition: Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.
imported from: oae.owl
imported from: uberon.owl
created by: cjm
creation date: 2009-04-08T04:38:19Z
database_cross_reference: CARO:0000081
has_obo_namespace: uberon
has_related_synonym: blood or blood analog
has_related_synonym: circulating fluid
id: UBERON:0000179

blastula
type: Class
equivalent class: Class
  intersection of: multicellular organism
  intersection of: Restriction
    on property: existence starts and ends during
    some values from: blastula stage
subclass of: embryo
subclass of: Restriction
  on property: develops_from
  some values from: cleaving embryo
subclass of: Restriction
  on property: existence starts and ends during
  some values from: blastula stage
definition: Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
editor note: TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: UBERON:0007011
database_cross_reference: Blastula
database_cross_reference: BILA:0000059
database_cross_reference: BTO:0000128
database_cross_reference: GAID:1294
database_cross_reference: MESH:A16.254.270.274
database_cross_reference: OGEM:000006
database_cross_reference: OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg
has exact synonym: blastula embryo
has_obo_namespace: uberon
has_related_synonym: blastosphere
id: UBERON:0000307
in subset: inconsistent with fma

musculature of body
type: Class
equivalent class: Class
  intersection of: organ system subdivision
  intersection of: Restriction
    on property: composed primarily of
    some values from: musculature
subclass of: organ system subdivision
subclass of: Restriction
  on property: part of
  some values from: musculoskeletal system
subclass of: Restriction
  on property: composed primarily of
  some values from: musculature
definition: The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified].
editor note: consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon 6040
external_definition: Anatomical system that consists of the muscles of the body.[VSAO]
external_ontology_notes: we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA
database_cross_reference: AAO:0000307
database_cross_reference: BILA:0000088
database_cross_reference: BTO:0001369
database_cross_reference: BTO:0001485
database_cross_reference: EFO:0000801
database_cross_reference: EMAPA:35578
database_cross_reference: FBbt:00005069
database_cross_reference: FMA:72954
database_cross_reference: MA:0002888
database_cross_reference: MAT:0000025
database_cross_reference: MIAA:0000025
database_cross_reference: VSAO:0000033
database_cross_reference: XAO:0004042
has exact synonym: muscle system
has exact synonym: muscle system of body
has exact synonym: muscular system
has exact synonym: musculature system
has exact synonym: set of all muscles
has exact synonym: set of muscles of body
has exact synonym: vertebrate muscular system
has_obo_namespace: uberon
has_related_synonym: muskelsystem
id: UBERON:0000383
in subset: efo slim
in subset: pheno slim

serous gland
type: Class
subclass of: exocrine gland
subclass of: Restriction
  on property: has part
  some values from: serous acinus
subclass of: Restriction
  on property: produces
  some values from: serous fluid
definition: A gland in which the principal secretory cells are serous secreting cells.
imported from: oae.owl
imported from: uberon.owl
external_definition: glands that secrete watery albuminous material that often contains enzymes[MP:0008052].
database_cross_reference: Serous gland
database_cross_reference: BTO:0001837
database_cross_reference: FMA:62889
has_obo_namespace: uberon
id: UBERON:0000409
in subset: organ slim
in subset: pheno slim

bodily secretion
type: Class
equivalent class: Class
  intersection of: organism substance
  intersection of: Restriction
    on property: produced_by
    some values from: exocrine gland
subclass of: organism substance
subclass of: Restriction
  on property: produced_by
  some values from: exocrine gland
definition: A portion of organism substance that is produced by exocrine glands.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions
has_alternative_id: UBERON:0006540
has_broad_synonym: secretion
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1516992
database_cross_reference: C34062
database_cross_reference: AEO:0001005
database_cross_reference: BTO:0002977
database_cross_reference: BTO:0002979
database_cross_reference: EMAPA:36535
database_cross_reference: FMA:9675
database_cross_reference: MA:0002504
database_cross_reference: MESH:D012634
database_cross_reference: UMLS:C1516992
database_cross_reference: galen:Secretion
has exact synonym: exocrine gland fluid/secretion
has exact synonym: secreted substance
has_obo_namespace: uberon
has_related_synonym: exocrine gland fluid
has_related_synonym: exocrine gland fluid or secretion
has_related_synonym: exocrine gland secretion
has_related_synonym: external secretion
id: UBERON:0000456

organism substance
type: Class
subclass of: material anatomical entity
subclass of: Restriction
  on property: part of
  some values from: multicellular organism
editor preferred label: organism substance
definition: Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: uberon.owl
database_cross_reference: C13236
database_cross_reference: AAO:0010839
database_cross_reference: AEO:0000004
database_cross_reference: BILA:0000004
database_cross_reference: CALOHA:TS-2101
database_cross_reference: CARO:0000004
database_cross_reference: EHDAA2:0003004
database_cross_reference: EMAPA:35178
database_cross_reference: FBbt:00007019
database_cross_reference: FMA:9669
database_cross_reference: HAO:0000004
database_cross_reference: MA:0002450
database_cross_reference: SPD:0000008
database_cross_reference: TAO:0001487
database_cross_reference: TGMA:0001824
database_cross_reference: VHOG:0001726
database_cross_reference: XAO:0004001
database_cross_reference: ZFA:0001487
database_cross_reference: galen:BodySubstance
has exact synonym: body fluid or substance
has exact synonym: body substance
has exact synonym: organism substance
has exact synonym: portion of body substance
has exact synonym: portion of organism substance
has_obo_namespace: uberon
id: UBERON:0000463
in subset: upper level
in subset: pheno slim

anatomical space
type: Class
subclass of: immaterial anatomical entity
subclass of: Restriction
  on property: surrounded by
  some values from: anatomical structure
definition: Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: lumen
has_broad_synonym: space
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0524461
database_cross_reference: C94478
database_cross_reference: AAO:0010110
database_cross_reference: AEO:0000005
database_cross_reference: BILA:0000005
database_cross_reference: CARO:0000005
database_cross_reference: EHDAA2:0003005
database_cross_reference: FBbt:00007017
database_cross_reference: FMA:5897
database_cross_reference: HAO:0000005
database_cross_reference: TAO:0001668
database_cross_reference: TGMA:0001825
database_cross_reference: UMLS:C0524461
database_cross_reference: VHOG:0001728
database_cross_reference: XAO:0003190
database_cross_reference: ZFA:0001643
has exact synonym: lumen space
has_obo_namespace: uberon
has_related_synonym: anatomical spaces
id: UBERON:0000464
in subset: upper level

material anatomical entity
type: Class
subclass of: material entity
subclass of: anatomical entity
editor preferred label: material anatomical entity
definition: Anatomical entity that has mass.
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: uberon.owl
database_cross_reference: AAO:0010264
database_cross_reference: AEO:0000006
database_cross_reference: BILA:0000006
database_cross_reference: CARO:0000006
database_cross_reference: EHDAA2:0003006
database_cross_reference: FBbt:00007016
database_cross_reference: FMA:67165
database_cross_reference: HAO:0000006
database_cross_reference: TAO:0001836
database_cross_reference: TGMA:0001826
database_cross_reference: VHOG:0001721
has_obo_namespace: uberon
id: UBERON:0000465
in subset: upper level

immaterial anatomical entity
type: Class
subclass of: anatomical entity
definition: Anatomical entity that has no mass.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0010265
database_cross_reference: AEO:0000007
database_cross_reference: BILA:0000007
database_cross_reference: CARO:0000007
database_cross_reference: EHDAA2:0003007
database_cross_reference: FBbt:00007015
database_cross_reference: FMA:67112
database_cross_reference: HAO:0000007
database_cross_reference: TAO:0001835
database_cross_reference: TGMA:0001827
database_cross_reference: VHOG:0001727
has exact synonym: immaterial physical anatomical entity
has_obo_namespace: uberon
id: UBERON:0000466
in subset: disjointness axiom removed
in subset: upper level

anatomical system
type: Class
subclass of: anatomical structure
subclass of: Restriction
  on property: part of
  some values from: multicellular organism
subclass of: Restriction
  on property: has part
  some values from: organ
subclass of: Restriction
  on property: existence starts during or after
  some values from: organogenesis stage
definition: Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: system
database_cross_reference: Organ system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0460002
database_cross_reference: C12919
database_cross_reference: birnlex 14
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278195005
database_cross_reference: AAO:0000007
database_cross_reference: AEO:0000011
database_cross_reference: BILA:0000011
database_cross_reference: BSA:0000049
database_cross_reference: CALOHA:TS-2088
database_cross_reference: CARO:0000011
database_cross_reference: EHDAA2:0003011
database_cross_reference: EHDAA:392
database_cross_reference: EMAPA:16103
database_cross_reference: EV:0100000
database_cross_reference: FBbt:00004856
database_cross_reference: FMA:7149
database_cross_reference: HAO:0000011
database_cross_reference: MA:0000003
database_cross_reference: OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ
database_cross_reference: TAO:0001439
database_cross_reference: TGMA:0001831
database_cross_reference: UMLS:C0460002
database_cross_reference: VHOG:0001725
database_cross_reference: WBbt:0005746
database_cross_reference: WBbt:0005763
database_cross_reference: XAO:0003002
database_cross_reference: ZFA:0001439
database_cross_reference: galen:AnatomicalSystem
has exact synonym: body system
has exact synonym: connected anatomical system
has exact synonym: organ system
has_obo_namespace: uberon
has_related_synonym: anatomical systems
id: UBERON:0000467
in subset: uberon slim
in subset: upper level
in subset: pheno slim

multicellular organism
type: Class
subclass of: multicellular anatomical structure
definition: Anatomical structure that is an individual member of a species and consists of more than one cell.
editor note: TODO - split body and mc organism? body continues after death stage
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: organismal
database_cross_reference: Multi-cellular organism
database_cross_reference: C13041
database_cross_reference: birnlex 18
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/243928005
database_cross_reference: AAO:0010026
database_cross_reference: AEO:0000191
database_cross_reference: BILA:0000012
database_cross_reference: BSA:0000038
database_cross_reference: BTO:0000042
database_cross_reference: CARO:0000012
database_cross_reference: EFO:0002906
database_cross_reference: EHDAA2:0003103
database_cross_reference: EHDAA2:0003191
database_cross_reference: EHDAA:1
database_cross_reference: EHDAA:9178
database_cross_reference: EMAPA:25765
database_cross_reference: EV:0100016
database_cross_reference: FBbt:00000001
database_cross_reference: FMA:256135
database_cross_reference: HAO:0000012
database_cross_reference: TADS:0000001
database_cross_reference: TAO:0001094
database_cross_reference: TGMA:0001832
database_cross_reference: VHOG:0000671
database_cross_reference: WBbt:0007833
database_cross_reference: XAO:0003004
database_cross_reference: ZFA:0001094
database_cross_reference: galen:Organism
database_cross_reference: ncithesaurus:Whole_Organism
has exact synonym: multi-cellular organism
has exact synonym: organism
has exact synonym: whole organism
has_narrow_synonym: animal
has_obo_namespace: uberon
has_related_synonym: Koerper
has_related_synonym: body
has_related_synonym: whole body
id: UBERON:0000468
in subset: uberon slim
in subset: upper level
in subset: efo slim
in subset: pheno slim

organism subdivision
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: multicellular organism
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: part of
    some values from: circulatory system
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: part of
    some values from: musculature
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: part of
    some values from: nervous system
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: part of
    some values from: skeletal system
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: part of
    some values from: integumental system
definition: Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.
editor note: Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Body part
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0229962
database_cross_reference: C32221
database_cross_reference: birnlex 7
database_cross_reference: AAO:0010053
database_cross_reference: AEO:0000032
database_cross_reference: BILA:0000032
database_cross_reference: CALOHA:TS-2084
database_cross_reference: CARO:0000032
database_cross_reference: EFO:0000808
database_cross_reference: EHDAA2:0003032
database_cross_reference: EMAPA:36031
database_cross_reference: FBbt:00007009
database_cross_reference: FMA:7153
database_cross_reference: HAO:0000032
database_cross_reference: MA:0002433
database_cross_reference: MAT:0000293
database_cross_reference: MESH:D001829
database_cross_reference: MIAA:0000293
database_cross_reference: OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001308
database_cross_reference: TGMA:0001840
database_cross_reference: UMLS:C0229962
database_cross_reference: VHOG:0001758
database_cross_reference: XAO:0003013
database_cross_reference: ZFA:0001308
database_cross_reference: galen:BodyPart
has exact synonym: anatomic region
has_obo_namespace: uberon
has_related_synonym: body part
has_related_synonym: body region
has_related_synonym: cardinal body part
id: UBERON:0000475
in subset: uberon slim
in subset: upper level
in subset: efo slim
in subset: pheno slim

acellular anatomical structure
type: Class
subclass of: anatomical structure
definition: Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0010268
database_cross_reference: AEO:0000040
database_cross_reference: BILA:0000040
database_cross_reference: CARO:0000040
database_cross_reference: EHDAA2:0003040
database_cross_reference: FBbt:00007013
database_cross_reference: FMA:63863
database_cross_reference: HAO:0000040
database_cross_reference: TAO:0000382
database_cross_reference: TGMA:0001841
database_cross_reference: XAO:0003162
database_cross_reference: ZFA:0000382
has_obo_namespace: uberon
has_related_synonym: acellular anatomical structures
id: UBERON:0000476
in subset: vertebrate core

anatomical cluster
type: Class
subclass of: material entity
subclass of: anatomical entity
editor preferred label: anatomical cluster
definition: Anatomical group that has its parts adjacent to one another.
editor note: Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3]
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: uberon.owl
database_cross_reference: AAO:0010009
database_cross_reference: AEO:0000041
database_cross_reference: BILA:0000041
database_cross_reference: CARO:0000041
database_cross_reference: EHDAA2:0003041
database_cross_reference: FBbt:00007277
database_cross_reference: FMA:49443
database_cross_reference: HAO:0000041
database_cross_reference: TADS:0000605
database_cross_reference: TAO:0001478
database_cross_reference: TGMA:0001842
database_cross_reference: VHOG:0001737
database_cross_reference: XAO:0003160
database_cross_reference: ZFA:0001478
has_obo_namespace: uberon
id: UBERON:0000477
in subset: disjointness axiom removed
in subset: upper level

tissue
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: multicellular organism
definition: Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.
editor note: changed label and definition to reflect CARO2
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0040300
database_cross_reference: C12801
database_cross_reference: birnlex 19
database_cross_reference: AAO:0000607
database_cross_reference: AAO:0010054
database_cross_reference: AEO:0000043
database_cross_reference: BILA:0000043
database_cross_reference: CALOHA:TS-2090
database_cross_reference: CARO:0000043
database_cross_reference: EHDAA2:0003043
database_cross_reference: EMAPA:35868
database_cross_reference: FBbt:00007003
database_cross_reference: FMA:9637
database_cross_reference: HAO:0000043
database_cross_reference: MA:0003002
database_cross_reference: MESH:D014024
database_cross_reference: TAO:0001477
database_cross_reference: TGMA:0001844
database_cross_reference: UMLS:C0040300
database_cross_reference: VHOG:0001757
database_cross_reference: WBbt:0005729
database_cross_reference: XAO:0003040
database_cross_reference: ZFA:0001477
database_cross_reference: galen:Tissue
has exact synonym: portion of tissue
has exact synonym: tissue portion
has_narrow_synonym: simple tissue
has_obo_namespace: uberon
id: UBERON:0000479
in subset: upper level
in subset: pheno slim

multi-tissue structure
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: has part
  some values from: tissue
definition: Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0010048
database_cross_reference: AEO:0000055
database_cross_reference: BILA:0000055
database_cross_reference: CARO:0000055
database_cross_reference: EHDAA2:0003055
database_cross_reference: FBbt:00007010
database_cross_reference: HAO:0000055
database_cross_reference: TAO:0001488
database_cross_reference: TGMA:0001847
database_cross_reference: VHOG:0001762
database_cross_reference: XAO:0003037
database_cross_reference: ZFA:0001488
has_obo_namespace: uberon
has_related_synonym: multi-tissue structures
id: UBERON:0000481
in subset: upper level

epithelium
type: Class
equivalent class: Class
  union of: multilaminar epithelium
  union of: unilaminar epithelium
subclass of: tissue
subclass of: Restriction
  on property: has part
  some values from: basement membrane of epithelium
definition: Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].
imported from: oae.owl
imported from: uberon.owl
homology_notes: The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]
has_relational_adjective: epithelial
database_cross_reference: Epithelium
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0014609
database_cross_reference: C12710
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/31610004
database_cross_reference: AAO:0000144
database_cross_reference: AAO:0010055
database_cross_reference: AEO:0000066
database_cross_reference: BILA:0000066
database_cross_reference: BTO:0000416
database_cross_reference: CALOHA:TS-0288
database_cross_reference: CARO:0000066
database_cross_reference: EHDAA2:0003066
database_cross_reference: EMAPA:32738
database_cross_reference: FBbt:00007005
database_cross_reference: FMA:9639
database_cross_reference: GAID:402
database_cross_reference: HAO:0000066
database_cross_reference: MA:0003060
database_cross_reference: MESH:D004848
database_cross_reference: TAO:0001486
database_cross_reference: UMLS:C0014609
database_cross_reference: VHOG:0000387
database_cross_reference: XAO:0003045
database_cross_reference: ZFA:0001486
has exact synonym: epithelial tissue
has exact synonym: portion of epithelium
has_obo_namespace: uberon
id: UBERON:0000483
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

multilaminar epithelium
type: Class
subclass of: epithelium
definition: Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]
imported from: oae.owl
imported from: uberon.owl
external_definition: Epithelium that consists of more than one layer of epithelial cells.[CARO]
database_cross_reference: Stratified epithelium
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0682575
database_cross_reference: C33622
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/309044005
database_cross_reference: AAO:0010059
database_cross_reference: AEO:0000069
database_cross_reference: BILA:0000069
database_cross_reference: BTO:0002074
database_cross_reference: CARO:0000069
database_cross_reference: EHDAA2:0003069
database_cross_reference: FMA:45562
database_cross_reference: HAO:0000069
database_cross_reference: TAO:0001494
database_cross_reference: UMLS:C0682575
database_cross_reference: XAO:0004006
database_cross_reference: ZFA:0001494
has exact synonym: stratified epithelium
has_obo_namespace: uberon
has_related_synonym: laminated epithelium
id: UBERON:0000486
in subset: uberon slim
in subset: vertebrate core

simple squamous epithelium
type: Class
subclass of: unilaminar epithelium
subclass of: squamous epithelium
definition: Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]
imported from: oae.owl
imported from: uberon.owl
external_definition: Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]
database_cross_reference: Simple squamous epithelium
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0836133
database_cross_reference: C13178
database_cross_reference: AAO:0010066
database_cross_reference: AEO:0000070
database_cross_reference: BILA:0000070
database_cross_reference: BTO:0002073
database_cross_reference: CARO:0000070
database_cross_reference: EHDAA2:0003070
database_cross_reference: FMA:45565
database_cross_reference: HAO:0000070
database_cross_reference: TAO:0001498
database_cross_reference: UMLS:C0836133
database_cross_reference: XAO:0004010
database_cross_reference: ZFA:0001498
has exact synonym: epithelium simplex squamosum
has_obo_namespace: uberon
has_related_synonym: simple squamous epithelia
id: UBERON:0000487
in subset: uberon slim
in subset: vertebrate core

unilaminar epithelium
type: Class
subclass of: epithelium
definition: Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]
editor note: consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable
imported from: oae.owl
imported from: uberon.owl
external_definition: Epithelium that consists of a single layer of epithelial cells.[CARO]
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0682574
database_cross_reference: C33554
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/309043004
database_cross_reference: AAO:0010062
database_cross_reference: AEO:0000073
database_cross_reference: BILA:0000073
database_cross_reference: BTO:0002073
database_cross_reference: CARO:0000073
database_cross_reference: EHDAA2:0003073
database_cross_reference: FMA:45561
database_cross_reference: HAO:0000073
database_cross_reference: TAO:0001495
database_cross_reference: UMLS:C0682574
database_cross_reference: XAO:0004007
database_cross_reference: ZFA:0001495
has exact synonym: simple epithelium
has_obo_namespace: uberon
has_related_synonym: unilaminar epithelia
id: UBERON:0000490
in subset: vertebrate core

thoracic segment of trunk
type: Class
equivalent class: Class
  intersection of: subdivision of organism along main body axis
  intersection of: Restriction
    on property: has skeleton
    some values from: thoracic skeleton
subclass of: subdivision of trunk
subclass of: subdivision of organism along main body axis
subclass of: Restriction
  on property: has skeleton
  some values from: thoracic skeleton
definition: Subdivision of trunk that lies between the head and the abdomen.
curator note: note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest
imported from: oae.owl
imported from: uberon.owl
spatially disjoint from: appendage
spatially disjoint from: head
spatially disjoint from: abdominal segment of trunk
database_cross_reference: Thorax
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302551006
database_cross_reference: EMAPA:35862
database_cross_reference: FMA:259209
database_cross_reference: MA:0000022
has exact synonym: thorax
has_obo_namespace: uberon
has_related_synonym: anterior subdivision of trunk
has_related_synonym: upper body
has_related_synonym: upper trunk
id: UBERON:0000915
in subset: uberon slim

embryo
type: Class
equivalent class: Class
  intersection of: multicellular organism
  intersection of: Restriction
    on property: existence starts with
    some values from: embryo stage
  intersection of: Restriction
    on property: existence ends with
    some values from: embryo stage
subclass of: multicellular organism
subclass of: Restriction
  on property: existence starts with
  some values from: embryo stage
subclass of: Restriction
  on property: existence ends with
  some values from: embryo stage
definition: Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: embryonic
external_ontology_notes: Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo
database_cross_reference: Embryo
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013935
database_cross_reference: C28147
database_cross_reference: Category:Embryonic organism
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/57991002
database_cross_reference: AAO:0011035
database_cross_reference: AEO:0000169
database_cross_reference: BILA:0000056
database_cross_reference: BSA:0000039
database_cross_reference: BTO:0000379
database_cross_reference: CALOHA:TS-0229
database_cross_reference: EFO:0001367
database_cross_reference: EHDAA2:0000002
database_cross_reference: EHDAA2_RETIRED:0003236
database_cross_reference: EHDAA:38
database_cross_reference: EMAPA:16039
database_cross_reference: FBbt:00000052
database_cross_reference: FMA:69068
database_cross_reference: GAID:963
database_cross_reference: MAT:0000226
database_cross_reference: MESH:D004622
database_cross_reference: MIAA:0000019
database_cross_reference: OGEM:000001
database_cross_reference: OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0013935
database_cross_reference: VHOG:0001766
database_cross_reference: XAO:0000113
database_cross_reference: ZFA:0000103
has exact synonym: embryonic organism
has_obo_namespace: uberon
has_related_synonym: developing organism
has_related_synonym: developmental tissue
id: UBERON:0000922
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

germ layer
type: Class
subclass of: germ layer / neural crest
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: epiblast (generic)
definition: A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.
imported from: oae.owl
imported from: uberon.owl
homology_notes: The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
has_broad_synonym: embryonic tissue
database_cross_reference: Germ layer
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0920502
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1708239
database_cross_reference: C12950
database_cross_reference: C54105
database_cross_reference: AAO:0000480
database_cross_reference: BILA:0000035
database_cross_reference: BTO:0000556
database_cross_reference: EMAPA:36033
database_cross_reference: FBbt:00000110
database_cross_reference: FMA:69069
database_cross_reference: GAID:1303
database_cross_reference: MESH:A16.254.425
database_cross_reference: TAO:0001122
database_cross_reference: UMLS:C0920502
database_cross_reference: UMLS:C1708239
database_cross_reference: VHOG:0001223
database_cross_reference: XAO:0003011
database_cross_reference: ZFA:0001122
has exact synonym: germinal layer
has_narrow_synonym: primary germ layer
has_obo_namespace: uberon
has_related_synonym: embryonic germ layer
has_related_synonym: embryonic germ layers
id: UBERON:0000923
in subset: uberon slim
in subset: vertebrate core
comment: Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]

ectoderm
type: Class
subclass of: germ layer
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive ectoderm
definition: Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
imported from: oae.owl
imported from: uberon.owl
external_definition: Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
homology_notes: The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
has_relational_adjective: ectodermal
database_cross_reference: Ectoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013574
database_cross_reference: C12703
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362851007
database_cross_reference: AAO:0000137
database_cross_reference: BILA:0000036
database_cross_reference: BTO:0000315
database_cross_reference: CALOHA:TS-0216
database_cross_reference: EFO:0000414
database_cross_reference: EHDAA2:0000428
database_cross_reference: EMAPA:16069
database_cross_reference: EV:0100003
database_cross_reference: FBbt:00000111
database_cross_reference: FMA:69070
database_cross_reference: GAID:1304
database_cross_reference: MAT:0000155
database_cross_reference: MAT:0000173
database_cross_reference: MESH:A16.254.425.273
database_cross_reference: MIAA:0000173
database_cross_reference: TAO:0000016
database_cross_reference: UMLS:C0013574
database_cross_reference: VHOG:0000153
database_cross_reference: XAO:0000001
database_cross_reference: ZFA:0000016
has exact synonym: embryonic ectoderm
has_obo_namespace: uberon
id: UBERON:0000924
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

endoderm
type: Class
subclass of: germ layer
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive endoderm
definition: Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
imported from: oae.owl
imported from: uberon.owl
homology_notes: The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
has_relational_adjective: endodermal
database_cross_reference: Endoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0014144
database_cross_reference: C12706
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362855003
database_cross_reference: AAO:0000139
database_cross_reference: BILA:0000038
database_cross_reference: BTO:0000800
database_cross_reference: CALOHA:TS-0273
database_cross_reference: EFO:0002545
database_cross_reference: EHDAA2:0000436
database_cross_reference: EMAPA:16062
database_cross_reference: EV:0100005
database_cross_reference: FBbt:00000125
database_cross_reference: FMA:69071
database_cross_reference: GAID:1305
database_cross_reference: MAT:0000175
database_cross_reference: MESH:A16.254.425.407
database_cross_reference: MIAA:0000175
database_cross_reference: TAO:0000017
database_cross_reference: UMLS:C0014144
database_cross_reference: VHOG:0000154
database_cross_reference: XAO:0000090
database_cross_reference: ZFA:0000017
has_obo_namespace: uberon
has_related_synonym: entoderm
id: UBERON:0000925
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

mesoderm
type: Class
subclass of: germ layer
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive mesoderm
definition: The middle germ layer of the embryo, between the endoderm and ectoderm.
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon 6040
external_definition: Primary germ layer that is the middle of the embryonic germ layers.[AAO]
homology_notes: The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
has_relational_adjective: mesodermal
taxon_notes: sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates
has_alternative_id: UBERON:0003263
database_cross_reference: Mesoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0025485
database_cross_reference: C12750
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362854004
database_cross_reference: AAO:0000304
database_cross_reference: BILA:0000037
database_cross_reference: BTO:0000839
database_cross_reference: CALOHA:TS-0623
database_cross_reference: EFO:0001981
database_cross_reference: EHDAA2:0001128
database_cross_reference: EHDAA:124
database_cross_reference: EHDAA:160
database_cross_reference: EHDAA:168
database_cross_reference: EHDAA:183
database_cross_reference: EMAPA:16083
database_cross_reference: EV:0100006
database_cross_reference: FBbt:00000126
database_cross_reference: FMA:69072
database_cross_reference: GAID:522
database_cross_reference: MAT:0000174
database_cross_reference: MESH:A16.254.425.660
database_cross_reference: MIAA:0000174
database_cross_reference: TAO:0000041
database_cross_reference: UMLS:C0025485
database_cross_reference: VHOG:0000152
database_cross_reference: XAO:0000050
database_cross_reference: ZFA:0000041
has_obo_namespace: uberon
has_related_synonym: embryonic mesoderm
has_related_synonym: entire mesoderm
has_related_synonym: mesodermal mantle
id: UBERON:0000926
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

stomodeum
type: Class
subclass of: embryonic structure
subclass of: subdivision of tube
subclass of: Restriction
  on property: part of
  some values from: ectoderm
subclass of: Restriction
  on property: part of
  some values from: future mouth
definition: Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity.
editor note: consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence
imported from: oae.owl
imported from: uberon.owl
external_definition: Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]
external_definition: the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx
has_relational_adjective: stomodeal
taxon_notes: This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity.
has_broad_synonym: stomodeal-hypophyseal primordium
database_cross_reference: Stomodeum
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1514977
database_cross_reference: C34306
database_cross_reference: BTO:0004224
database_cross_reference: EHDAA2:0001929
database_cross_reference: EMAPA:16263
database_cross_reference: FBbt:00000439
database_cross_reference: FMA:295846
database_cross_reference: TAO:0001290
database_cross_reference: TGMA:0000135
database_cross_reference: UMLS:C1514977
database_cross_reference: XAO:0000269
database_cross_reference: ZFA:0001290
has exact synonym: mouth primordium
has exact synonym: primitive oral cavity
has exact synonym: stomatodeum
has exact synonym: stomodaeum
has_obo_namespace: uberon
has_related_synonym: mouth pit
has_related_synonym: oral ectoderm
has_related_synonym: oral pit
id: UBERON:0000930
in subset: grouping class
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

heart
type: Class
equivalent class: Class
  intersection of: primary circulatory organ
  intersection of: Restriction
    on property: has part
    some values from: cardiac chamber
subclass of: mesoderm-derived structure
subclass of: thoracic segment organ
subclass of: primary circulatory organ
subclass of: structure with developmental contribution from neural crest
subclass of: Restriction
  on property: part of
  some values from: heart plus pericardium
subclass of: Restriction
  on property: has part
  some values from: cardiac chamber
subclass of: Restriction
  on property: develops_from
  some values from: heart tube
subclass of: Restriction
  on property: has developmental contribution from
  some values from: neural crest
subclass of: Restriction
  on property: contributes to morphology of
  some values from: cardiovascular system
definition: A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.
imported from: oae.owl
imported from: uberon.owl
external_definition: Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]
external_definition: Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]
axiom_lost_from_external_ontology: relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]
homology_notes: As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]
has_relational_adjective: cardiac
database_cross_reference: Heart
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0018787
database_cross_reference: C12727
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302509004
database_cross_reference: AAO:0010210
database_cross_reference: BILA:0000020
database_cross_reference: BTO:0000562
database_cross_reference: CALOHA:TS-0445
database_cross_reference: EFO:0000815
database_cross_reference: EHDAA2:0000738
database_cross_reference: EHDAA:420
database_cross_reference: EMAPA:16105
database_cross_reference: EV:0100018
database_cross_reference: FMA:7088
database_cross_reference: GAID:174
database_cross_reference: MA:0000072
database_cross_reference: MAT:0000036
database_cross_reference: MESH:D006321
database_cross_reference: MIAA:0000036
database_cross_reference: OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000114
database_cross_reference: UMLS:C0018787
database_cross_reference: VHOG:0000276
database_cross_reference: XAO:0000064
database_cross_reference: ZFA:0000114
database_cross_reference: galen:Heart
has exact synonym: chambered heart
has exact synonym: vertebrate heart
has_narrow_synonym: branchial heart
has_obo_namespace: uberon
has_related_synonym: Herz@de
has_related_synonym: cardium
id: UBERON:0000948
in subset: major organ
in subset: organ slim
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim
comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" http://dx.doi.org/10.1101/gad.1485706

skeletal joint
type: Class
equivalent class: Class
  union of: synovial joint
  union of: nonsynovial joint
subclass of: articulation
subclass of: Restriction
  on property: part of
  some values from: articular system
subclass of: Restriction
  on property: connects
  some values from: skeletal element
subclass of: Restriction
  on property: contributes to morphology of
  some values from: skeletal system
definition: Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO]
external_definition: Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO]
has_broad_synonym: articulation
has_broad_synonym: joint
database_cross_reference: Joint
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0022417
database_cross_reference: C13044
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302536002
database_cross_reference: AEO:0000182
database_cross_reference: BTO:0001686
database_cross_reference: CALOHA:TS-2023
database_cross_reference: EFO:0000948
database_cross_reference: EMAPA:35456
database_cross_reference: FMA:7490
database_cross_reference: GAID:102
database_cross_reference: MA:0000319
database_cross_reference: MAT:0000188
database_cross_reference: MESH:D007596
database_cross_reference: MIAA:0000188
database_cross_reference: OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA
database_cross_reference: RETIRED_EHDAA2:0003182
database_cross_reference: TAO:0000367
database_cross_reference: UMLS:C0022417
database_cross_reference: VHOG:0001276
database_cross_reference: VSAO:0000101
database_cross_reference: XAO:0000171
database_cross_reference: ZFA:0001596
database_cross_reference: galen:Joint
has_obo_namespace: uberon
has_related_synonym: articular joint
has_related_synonym: joints
id: UBERON:0000982
in subset: organ slim
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

skin epidermis
type: Class
equivalent class: Class
  intersection of: outer epithelium
  intersection of: Restriction
    on property: part of
    some values from: skin of body
subclass of: outer epithelium
subclass of: external integument structure
subclass of: Restriction
  on property: part of
  some values from: skin of body
subclass of: Restriction
  on property: adjacent_to
  some values from: dermis
subclass of: Restriction
  on property: developmentally_replaces
  some values from: periderm
definition: The outer epithelial layer of the skin that is superficial to the dermis.
imported from: oae.owl
imported from: uberon.owl
external_definition: A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO]
external_definition: The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO]
axiom_lost_from_external_ontology: relationship loss: subclass external integument structures (AAO:0000961)[AAO]
homology_notes: (...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG]
has_relational_adjective: epidermal
taxon_notes: Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes).
has_broad_synonym: epidermis
has_broad_synonym: skin
database_cross_reference: Epidermis (skin)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0014520
database_cross_reference: C12708
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361694003
database_cross_reference: AAO:0000143
database_cross_reference: BTO:0000404
database_cross_reference: CALOHA:TS-0283
database_cross_reference: EFO:0000954
database_cross_reference: EMAPA:17528
database_cross_reference: EV:0100153
database_cross_reference: FMA:70596
database_cross_reference: GAID:932
database_cross_reference: MA:0000153
database_cross_reference: MAT:0000154
database_cross_reference: MESH:D004817
database_cross_reference: MIAA:0000154
database_cross_reference: TAO:0000105
database_cross_reference: UMLS:C0014520
database_cross_reference: VHOG:0000077
database_cross_reference: XAO:0000028
database_cross_reference: ZFA:0000105
has exact synonym: vertebrate epidermis
has_obo_namespace: uberon
id: UBERON:0001003
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

respiratory system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: Functional system which consists of structures involved in respiration.
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon_147099
external_definition: The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]
homology_notes: There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]
database_cross_reference: Respiratory system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0035237
database_cross_reference: C12779
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278197002
database_cross_reference: AAO:0000541
database_cross_reference: BTO:0000203
database_cross_reference: CALOHA:TS-1319
database_cross_reference: EFO:0000804
database_cross_reference: EHDAA2:0001604
database_cross_reference: EHDAA:2203
database_cross_reference: EMAPA:16727
database_cross_reference: EV:0100036
database_cross_reference: FMA:7158
database_cross_reference: GAID:78
database_cross_reference: MA:0000327
database_cross_reference: MAT:0000030
database_cross_reference: MESH:D012137
database_cross_reference: MIAA:0000030
database_cross_reference: OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000272
database_cross_reference: UMLS:C0035237
database_cross_reference: VHOG:0000202
database_cross_reference: XAO:0000117
database_cross_reference: ZFA:0000272
has exact synonym: apparatus respiratorius
has exact synonym: respiratory system
has_obo_namespace: uberon
has_related_synonym: Atmungssystem
has_related_synonym: apparatus respiratorius
has_related_synonym: systema respiratorium
id: UBERON:0001004
in subset: functional classification
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

digestive system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.
imported from: oae.owl
imported from: uberon.owl
external_definition: An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]
has_relational_adjective: digestive
external_ontology_notes: many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class
database_cross_reference: Digestive system
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278859004
database_cross_reference: AAO:0000129
database_cross_reference: BILA:0000082
database_cross_reference: BTO:0000058
database_cross_reference: CALOHA:TS-1293
database_cross_reference: EFO:0000793
database_cross_reference: EV:0100056
database_cross_reference: FBbt:00005055
database_cross_reference: FMA:7152
database_cross_reference: GAID:278
database_cross_reference: MA:0002431
database_cross_reference: MAT:0000018
database_cross_reference: MESH:D004064
database_cross_reference: MIAA:0000018
database_cross_reference: TADS:0000170
database_cross_reference: TAO:0000339
database_cross_reference: WBbt:0005748
database_cross_reference: XAO:0000125
database_cross_reference: ZFA:0000339
database_cross_reference: galen:DigestiveSystem
database_cross_reference: ncithesaurus:Digestive_System
has_obo_namespace: uberon
has_related_synonym: alimentary system
has_related_synonym: alimentary tract
has_related_synonym: gastrointestinal system
has_related_synonym: gut
id: UBERON:0001007
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

renal system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products..
editor note: In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon_110815
never in taxon: NCBITaxon_147099
external_definition: An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO]
homology_notes: Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG]
taxon_notes: In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels
taxon_notes: This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans
database_cross_reference: Excretory system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1508753
database_cross_reference: C12413
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362204003
database_cross_reference: AAO:0010257
database_cross_reference: BILA:0000015
database_cross_reference: BTO:0001244
database_cross_reference: BTO:0003092
database_cross_reference: CALOHA:TS-1323
database_cross_reference: EFO:0000803
database_cross_reference: EHDAA2:0001601
database_cross_reference: EHDAA:5901
database_cross_reference: EMAPA:17366
database_cross_reference: EV:0100095
database_cross_reference: FBbt:00005056
database_cross_reference: FMA:7159
database_cross_reference: GAID:391
database_cross_reference: MA:0000325
database_cross_reference: MAT:0000027
database_cross_reference: MESH:D014551
database_cross_reference: MIAA:0000027
database_cross_reference: TADS:0000162
database_cross_reference: TAO:0000163
database_cross_reference: UMLS:C1508753
database_cross_reference: VHOG:0000723
database_cross_reference: WBbt:0005736
database_cross_reference: XAO:0000143
database_cross_reference: ZFA:0000163
database_cross_reference: galen:UrinaryTract
has exact synonym: excretory system
has exact synonym: renal system
has exact synonym: systema urinaria
has exact synonym: systema urinarium
has exact synonym: urinary system
has exact synonym: urinary tract
has_obo_namespace: uberon
has_related_synonym: renal or urinary system
has_related_synonym: renal/urinary system
id: UBERON:0001008
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

circulatory system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].
curator note: the cardiovascular system and the lymphatic system are parts of the circulatory system
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon_147099
never in taxon: NCBITaxon 6073
never in taxon: NCBITaxon 6157
dubious_for_taxon: NCBITaxon 6231
external_definition: Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]
homology_notes: We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG]
database_cross_reference: Circulatory system
database_cross_reference: AAO:0000959
database_cross_reference: CALOHA:TS-2103
database_cross_reference: FBbt:00005057
database_cross_reference: OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA
database_cross_reference: VHOG:0001248
has_obo_namespace: uberon
has_related_synonym: systema cardiovasculare
id: UBERON:0001009
in subset: uberon slim

adipose tissue
type: Class
subclass of: dense irregular connective tissue
definition: Portion of connective tissue composed of adipocytes enmeshed in areolar tissue
imported from: oae.owl
imported from: uberon.owl
external_definition: Connective tissue in which fat is stored.[TAO]
external_definition: Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO]
axiom_lost_from_external_ontology: relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]
homology_notes: Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG]
has_relational_adjective: adipose
taxon_notes: In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen.
external_ontology_notes: in FMA this is dense irregular connective tissue
database_cross_reference: Adipose tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0001527
database_cross_reference: C12472
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/55603005
database_cross_reference: AAO:0000001
database_cross_reference: AEO:000020
database_cross_reference: BTO:0001487
database_cross_reference: CALOHA:TS-0013
database_cross_reference: EFO:0000790
database_cross_reference: EHDAA2:0003120
database_cross_reference: EMAPA:35112
database_cross_reference: EV:0100381
database_cross_reference: FMA:20110
database_cross_reference: GAID:920
database_cross_reference: MA:0000009
database_cross_reference: MAT:0000015
database_cross_reference: MESH:D000273
database_cross_reference: MIAA:0000015
database_cross_reference: OpenCyc:Mx4rvVjc_ZwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0002134
database_cross_reference: UMLS:C0001527
database_cross_reference: VHOG:0001284
database_cross_reference: XAO:0003049
database_cross_reference: ZFA:0005345
database_cross_reference: galen:FattyTissue
has exact synonym: fat
has exact synonym: fat tissue
has exact synonym: fatty tissue
has_obo_namespace: uberon
has_related_synonym: adipose
has_related_synonym: bodyfat
has_related_synonym: fatty depot
id: UBERON:0001013
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

musculature
type: Class
subclass of: organ system subdivision
subclass of: Restriction
  on property: part of
  some values from: musculature of body
subclass of: Restriction
  on property: composed primarily of
  some values from: muscle organ
definition: A subdivision of the muscular system corresponding to a subdisivision of an organism.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here.
spatially disjoint from: bone element
database_cross_reference: Muscular system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0026845
database_cross_reference: C13056
database_cross_reference: AAO:0011066
database_cross_reference: BTO:0000887
database_cross_reference: EFO:0001949
database_cross_reference: EMAPA:32715
database_cross_reference: EMAPA:35577
database_cross_reference: FMA:32558
database_cross_reference: MA:0000165
database_cross_reference: OpenCyc:Mx4rvVjmr5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000548
database_cross_reference: UMLS:C0026845
database_cross_reference: VSAO:0005038
database_cross_reference: WBbt:0005737
database_cross_reference: ZFA:0000548
has exact synonym: muscle group
has exact synonym: muscles set
has exact synonym: musculature
has exact synonym: musculi
has exact synonym: set of muscles
has exact synonym: set of skeletal muscles
has_obo_namespace: uberon
has_related_synonym: muscle system
has_related_synonym: muscles
has_related_synonym: musculature system
id: UBERON:0001015
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

nervous system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
subclass of: Restriction
  on property: immediate transformation of
  some values from: future nervous system
definition: The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].
imported from: oae.owl
imported from: uberon.owl
external_definition: A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]
external_definition: Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]
homology_notes: Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]
has_relational_adjective: nervous
has_relational_adjective: neural
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Nervous system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0027763
database_cross_reference: C12755
database_cross_reference: birnlex 844
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278196006
database_cross_reference: AAO:0000324
database_cross_reference: BILA:0000079
database_cross_reference: BTO:0001484
database_cross_reference: CALOHA:TS-1313
database_cross_reference: EFO:0000802
database_cross_reference: EHDAA2:0001246
database_cross_reference: EHDAA:826
database_cross_reference: EMAPA:16469
database_cross_reference: EV:0100162
database_cross_reference: FBbt:00005093
database_cross_reference: FMA:7157
database_cross_reference: GAID:466
database_cross_reference: MA:0000016
database_cross_reference: MAT:0000026
database_cross_reference: MESH:D009420
database_cross_reference: MIAA:0000026
database_cross_reference: OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000396
database_cross_reference: UMLS:C0027763
database_cross_reference: VHOG:0000402
database_cross_reference: WBbt:0005735
database_cross_reference: XAO:0000177
database_cross_reference: ZFA:0000396
has exact synonym: neurological system
has_narrow_synonym: nerve net
has_obo_namespace: uberon
has_related_synonym: systema nervosum
id: UBERON:0001016
in subset: uberon slim
in subset: vertebrate core
in subset: cumbo
in subset: efo slim
in subset: pheno slim

central nervous system
type: Class
subclass of: ectoderm-derived structure
subclass of: organ system subdivision
subclass of: Restriction
  on property: part of
  some values from: nervous system
subclass of: Restriction
  on property: immediate transformation of
  some values from: future central nervous system
definition: The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon_147099
external_definition: Part of the nervous system which includes the brain and spinal cord.[AAO]
external_definition: The brain and spinal cord. Kimmel et al, 1995.[TAO]
external_definition: The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO).
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Central nervous system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0927232
database_cross_reference: C12438
database_cross_reference: birnlex 1099
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278199004
database_cross_reference: AAO:0000090
database_cross_reference: BAMS:CNS
database_cross_reference: BILA:0000080
database_cross_reference: BTO:0000227
database_cross_reference: CALOHA:TS-0150
database_cross_reference: EFO:0000908
database_cross_reference: EHDAA2:0000225
database_cross_reference: EHDAA:828
database_cross_reference: EMAPA:16470
database_cross_reference: EMAPA:16754
database_cross_reference: EV:0100163
database_cross_reference: FBbt:00005094
database_cross_reference: FMA:55675
database_cross_reference: GAID:570
database_cross_reference: MA:0000167
database_cross_reference: MAT:0000457
database_cross_reference: MESH:D002490
database_cross_reference: OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000012
database_cross_reference: UMLS:C0927232
database_cross_reference: VHOG:0000293
database_cross_reference: XAO:0000215
database_cross_reference: ZFA:0000012
has exact synonym: CNS
has exact synonym: systema nervosum centrale
has_narrow_synonym: cerebrospinal axis
has_obo_namespace: uberon
has_related_synonym: neuraxis
id: UBERON:0001017
in subset: uberon slim
in subset: vertebrate core
in subset: cumbo
in subset: efo slim
in subset: pheno slim

primordium
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: multicellular organism
definition: Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)].
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Primordium
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0678727
database_cross_reference: C34275
database_cross_reference: AEO:0000171
database_cross_reference: BTO:0001886
database_cross_reference: EFO:0001652
database_cross_reference: EHDAA2:0003171
database_cross_reference: FBbt:00005495
database_cross_reference: FMA:86589
database_cross_reference: MAT:0000482
database_cross_reference: UMLS:C0678727
database_cross_reference: XAO:0003043
has_obo_namespace: uberon
has_related_synonym: bud
has_related_synonym: future organ
has_related_synonym: placode
has_related_synonym: primordia
has_related_synonym: rudiment
id: UBERON:0001048
in subset: uberon slim
in subset: efo slim
in subset: pheno slim

neural tube
type: Class
subclass of: epithelial tube
subclass of: embryonic tissue
subclass of: ecto-epithelium
subclass of: future central nervous system
subclass of: Restriction
  on property: develops_from
  some values from: neural rod
definition: In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted].
imported from: oae.owl
imported from: uberon.owl
external_definition: Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]
external_definition: The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
development_notes: The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Neural tube
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0231024
database_cross_reference: C34226
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362852000
database_cross_reference: AAO:0010617
database_cross_reference: BTO:0001057
database_cross_reference: CALOHA:TS-2371
database_cross_reference: DHBA:10154
database_cross_reference: EHDAA2:0001254
database_cross_reference: EHDAA:2869
database_cross_reference: EHDAA:908
database_cross_reference: EMAPA:16164
database_cross_reference: EMAPA:16530
database_cross_reference: EMAPA:16757
database_cross_reference: FMA:293882
database_cross_reference: MAT:0000069
database_cross_reference: MIAA:0000069
database_cross_reference: TAO:0001135
database_cross_reference: UMLS:C0231024
database_cross_reference: VHOG:0000307
database_cross_reference: XAO:0003204
database_cross_reference: ZFA:0001135
has_obo_namespace: uberon
has_related_synonym: neural primordium
has_related_synonym: presumptive central nervous system
has_related_synonym: tubus neuralis
id: UBERON:0001049
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

anatomical entity
type: Class
subclass of: independent continuant
subclass of: material entity
definition: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1515976
database_cross_reference: C12219
database_cross_reference: birnlex 6
database_cross_reference: AAO:0010841
database_cross_reference: AEO:0000000
database_cross_reference: BILA:0000000
database_cross_reference: CARO:0000000
database_cross_reference: EHDAA2:0002229
database_cross_reference: FBbt:10000000
database_cross_reference: FBbt_root:00000000
database_cross_reference: FMA:62955
database_cross_reference: HAO:0000000
database_cross_reference: MA:0000001
database_cross_reference: TAO:0100000
database_cross_reference: TGMA:0001822
database_cross_reference: UMLS:C1515976
database_cross_reference: XAO:0000000
database_cross_reference: ZFA:0100000
has_obo_namespace: uberon
id: UBERON:0001062
in subset: upper level

synovial fluid
type: Class
equivalent class: Class
  intersection of: organism substance
  intersection of: Restriction
    on property: located_in
    some values from: synovial cavity of joint
subclass of: serous fluid
subclass of: Restriction
  on property: located_in
  some values from: synovial cavity of joint
definition: Transudate contained in the synovial cavity of joints, and in the cavity of tendon sheaths and bursae.
imported from: oae.owl
imported from: uberon.owl
external_definition: Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO]
database_cross_reference: Synovial fluid
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0039097
database_cross_reference: C33718
database_cross_reference: BTO:0001339
database_cross_reference: CALOHA:TS-0996
database_cross_reference: ENVO:02000039
database_cross_reference: FMA:12277
database_cross_reference: GAID:265
database_cross_reference: MA:0002544
database_cross_reference: MESH:D013582
database_cross_reference: TAO:0005154
database_cross_reference: UMLS:C0039097
database_cross_reference: ZFA:0005154
database_cross_reference: galen:SynovialFluid
has exact synonym: joint fluid
has_obo_namespace: uberon
id: UBERON:0001090
in subset: uberon slim
in subset: vertebrate core

mesothelium
type: Class
equivalent class: Class
  intersection of: simple squamous epithelium
  intersection of: Restriction
    on property: part of
    some values from: serous membrane
  intersection of: Restriction
    on property: develops_from
    some values from: mesoderm
subclass of: simple squamous epithelium
subclass of: meso-epithelium
subclass of: Restriction
  on property: part of
  some values from: serous membrane
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
definition: Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. http://en.wikipedia.org/wiki/ The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Mesothelium
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0086610
database_cross_reference: C33105
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361918002
database_cross_reference: AEO:0000111
database_cross_reference: BTO:0002422
database_cross_reference: CALOHA:TS-1183
database_cross_reference: EHDAA2_RETIRED:0003111
database_cross_reference: EHDAA:2331
database_cross_reference: EHDAA:2349
database_cross_reference: EHDAA:295
database_cross_reference: EHDAA:6073
database_cross_reference: EHDAA:640
database_cross_reference: EHDAA:646
database_cross_reference: EMAPA:32856
database_cross_reference: FMA:14074
database_cross_reference: MA:0000565
database_cross_reference: UMLS:C0086610
has_obo_namespace: uberon
id: UBERON:0001136
in subset: uberon slim

skeletal system
type: Class
equivalent class: Class
  intersection of: organ system subdivision
  intersection of: Restriction
    on property: has part
    some values from: skeleton
  intersection of: Restriction
    on property: has part
    some values from: articular system
subclass of: organ system subdivision
subclass of: Restriction
  on property: part of
  some values from: musculoskeletal system
subclass of: Restriction
  on property: has part
  some values from: skeleton
subclass of: Restriction
  on property: has part
  some values from: articular system
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO]
external_definition: Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO]
external_definition: System that provides physical support to the organism.[AAO]
homology_notes: By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG]
has_relational_adjective: skeletal
external_ontology_notes: GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates
spatially disjoint from: nervous system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0037253
database_cross_reference: C12788
database_cross_reference: AAO:0000566
database_cross_reference: BTO:0001486
database_cross_reference: CALOHA:TS-1320
database_cross_reference: EFO:0000806
database_cross_reference: EHDAA2:0003168
database_cross_reference: EMAPA:35773
database_cross_reference: FMA:23881
database_cross_reference: MA:0000018
database_cross_reference: OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000434
database_cross_reference: UMLS:C0037253
database_cross_reference: VHOG:0001254
database_cross_reference: VSAO:0000027
database_cross_reference: XAO:0003060
database_cross_reference: ZFA:0000434
has exact synonym: skeleton system
has_narrow_synonym: set of all bones and joints
has_obo_namespace: uberon
has_related_synonym: Skelettsystem
id: UBERON:0001434
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

bone element
type: Class
equivalent class: Class
  intersection of: skeletal element
  intersection of: Restriction
    on property: composed primarily of
    some values from: bone tissue
subclass of: skeletal element
subclass of: Restriction
  on property: part of
  some values from: skeletal system
subclass of: Restriction
  on property: composed primarily of
  some values from: bone tissue
definition: Skeletal element that is composed of bone tissue.
imported from: oae.owl
imported from: uberon.owl
external_definition: Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]
external_definition: Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO]
external_definition: Skeletal element that is composed of bone tissue.[VSAO]
axiom_lost_from_external_ontology: relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]
homology_notes: The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG]
spatially disjoint from: musculature
spatially disjoint from: muscle organ
spatially disjoint from: muscle tissue
database_cross_reference: Bone
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0262950
database_cross_reference: C12366
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/90780006
database_cross_reference: AAO:0000047
database_cross_reference: AEO:0000082
database_cross_reference: BTO:0000140
database_cross_reference: CALOHA:TS-0088
database_cross_reference: EFO:0000298
database_cross_reference: EHDAA2:0003082
database_cross_reference: EMAPA:32782
database_cross_reference: ENVO:00002039
database_cross_reference: EV:0100140
database_cross_reference: FMA:30317
database_cross_reference: FMA:5018
database_cross_reference: GAID:92
database_cross_reference: MA:0001459
database_cross_reference: MAT:0000299
database_cross_reference: MIAA:0000299
database_cross_reference: OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA
database_cross_reference: OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001514
database_cross_reference: UMLS:C0262950
database_cross_reference: VHOG:0001190
database_cross_reference: VSAO:0000057
database_cross_reference: XAO:0000169
database_cross_reference: ZFA:0001514
database_cross_reference: galen:Bone
has exact synonym: bone element
has exact synonym: bone organ
has_obo_namespace: uberon
has_related_synonym: bone
has_related_synonym: bones
id: UBERON:0001474
in subset: major organ
in subset: organ slim
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

articular capsule
type: Class
equivalent class: Class
  intersection of: membrane organ
  intersection of: Restriction
    on property: has part
    some values from: layer of synovial tissue
  intersection of: Restriction
    on property: surrounds
    some values from: synovial joint
subclass of: membrane organ
subclass of: Restriction
  on property: has part
  some values from: layer of synovial tissue
subclass of: Restriction
  on property: surrounds
  some values from: synovial joint
definition: An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: check ncita
database_cross_reference: Articular capsule
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0206207
database_cross_reference: C32259
database_cross_reference: C84388
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/182238002
database_cross_reference: FMA:34836
database_cross_reference: GAID:263
database_cross_reference: MA:0001519
database_cross_reference: MESH:D017746
database_cross_reference: UMLS:C0206207
database_cross_reference: galen:JointCapsule
has exact synonym: capsula articularis
has exact synonym: fibrous capsule of joint
has exact synonym: joint capsule
has exact synonym: joint fibrous capsule
has_obo_namespace: uberon
has_related_synonym: capsulae articulares
id: UBERON:0001484
in subset: organ slim
in subset: uberon slim

digestive tract
type: Class
subclass of: tube
subclass of: Restriction
  on property: part of
  some values from: digestive system
subclass of: Restriction
  on property: connects
  some values from: mouth
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive gut
definition: A tube extending from the mouth to the anus.
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon_147099
never in taxon: NCBITaxon_41324
external_definition: The alimentary or digestive tract, and associated organs.[TAO]
homology_notes: The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]
external_ontology_notes: FMA also has a term 'gastrointestinal tract', but this includes the liver.
external_ontology_notes: we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509
terminology_notes: we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this
has_broad_synonym: gut
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0017189
database_cross_reference: C34082
database_cross_reference: AAO:0010023
database_cross_reference: BILA:0000083
database_cross_reference: BTO:0000511
database_cross_reference: BTO:0000545
database_cross_reference: EHDAA2:0000726
database_cross_reference: EHDAA:518
database_cross_reference: EMAPA:16247
database_cross_reference: FBbt:00003125
database_cross_reference: FMA:45615
database_cross_reference: MA:0000917
database_cross_reference: OpenCyc:Mx4rvVi0GpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000112
database_cross_reference: TGMA:0001819
database_cross_reference: UMLS:C0017189
database_cross_reference: VHOG:0000309
database_cross_reference: WBbt:0005743
database_cross_reference: ZFA:0000112
database_cross_reference: galen:AlimentaryTract
has exact synonym: digestive tube
has exact synonym: enteric tract
has_narrow_synonym: alimentary canal
has_narrow_synonym: alimentary tract
has_obo_namespace: uberon
has_related_synonym: digestive canal
has_related_synonym: gut tube
id: UBERON:0001555
in subset: uberon slim
in subset: vertebrate core

muscle organ
type: Class
equivalent class: Class
  intersection of: organ
  intersection of: Restriction
    on property: composed primarily of
    some values from: muscle tissue
subclass of: organ
subclass of: muscle structure
subclass of: Restriction
  on property: part of
  some values from: musculature
subclass of: Restriction
  on property: composed primarily of
  some values from: muscle tissue
definition: Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO].
imported from: oae.owl
imported from: uberon.owl
external_definition: Portion of tissue composed of contractile fibers.[TAO]
homology_notes: It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG]
has_relational_adjective: muscular
has_broad_synonym: muscle
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/71616004
database_cross_reference: AAO:0011066
database_cross_reference: EMAPA:32715
database_cross_reference: EV:0100146
database_cross_reference: FMA:5022
database_cross_reference: GAID:131
database_cross_reference: MA:0000015
database_cross_reference: OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0005145
database_cross_reference: VHOG:0001245
database_cross_reference: XAO:0000172
database_cross_reference: ZFA:0005145
database_cross_reference: galen:Muscle
has_obo_namespace: uberon
id: UBERON:0001630
in subset: organ slim
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

blood plasma
type: Class
subclass of: haemolymphatic fluid
subclass of: Restriction
  on property: part of
  some values from: blood
definition: The liquid component of blood, in which erythrocytes are suspended.
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: plasma
has_broad_synonym: portion of plasma
database_cross_reference: Blood plasma
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0032105
database_cross_reference: C13356
database_cross_reference: BTO:0000131
database_cross_reference: CALOHA:TS-0800
database_cross_reference: EFO:0001905
database_cross_reference: EMAPA:35690
database_cross_reference: FMA:62970
database_cross_reference: GAID:1178
database_cross_reference: MA:0002501
database_cross_reference: MAT:0000052
database_cross_reference: MESH:D010949
database_cross_reference: MIAA:0000052
database_cross_reference: OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw
database_cross_reference: UMLS:C0032105
has exact synonym: blood plasm
has exact synonym: portion of blood plasma
has_obo_namespace: uberon
id: UBERON:0001969
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

blood vessel
type: Class
subclass of: vessel
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: blood vasculature
subclass of: Restriction
  on property: has part
  some values from: epithelial tube open at both ends
subclass of: Restriction
  on property: develops_from
  some values from: splanchnic layer of lateral plate mesoderm
subclass of: Restriction
  on property: develops_from
  some values from: vascular cord
subclass of: Restriction
  on property: channel for
  some values from: blood
definition: A vessel through which blood circulates in the body.
editor note: consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus
imported from: oae.owl
imported from: uberon.owl
external_definition: Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]
external_definition: Any of the vessels through which blood circulates in the body.[AAO]
homology_notes: The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]
taxon_notes: annelids have blood vessels, but this class is not applicable to annelids.
external_ontology_notes: FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX
has_broad_synonym: vascular element
database_cross_reference: Blood vessel
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0005847
database_cross_reference: C12679
database_cross_reference: nlx anat 090901
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361097006
database_cross_reference: AAO:0011004
database_cross_reference: AEO:0000207
database_cross_reference: BTO:0001102
database_cross_reference: CALOHA:TS-0080
database_cross_reference: EFO:0000817
database_cross_reference: EHDAA2:0003252
database_cross_reference: EHDAA:240
database_cross_reference: EMAPA:32743
database_cross_reference: EMAPA:35993
database_cross_reference: FMA:50722
database_cross_reference: FMA:63183
database_cross_reference: GAID:169
database_cross_reference: MA:0000060
database_cross_reference: MAT:0000393
database_cross_reference: MESH:D001808
database_cross_reference: OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0002137
database_cross_reference: UMLS:C0005847
database_cross_reference: VHOG:0001250
database_cross_reference: XAO:0001011
database_cross_reference: ZFA:0005314
has exact synonym: region of vascular tree organ
has exact synonym: vascular tree organ region
has_obo_namespace: uberon
has_related_synonym: vas sanguineum
id: UBERON:0001981
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

vasculature
type: Class
subclass of: anatomical cluster
subclass of: Restriction
  on property: part of
  some values from: vascular system
subclass of: Restriction
  on property: has part
  some values from: haemolymphatic fluid
subclass of: Restriction
  on property: composed primarily of
  some values from: vessel
definition: An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.
editor note: see also: vascular system. Consider merging?
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: vascular
database_cross_reference: BTO:0003718
database_cross_reference: FMA:69050
database_cross_reference: TAO:0005249
database_cross_reference: ZFA:0005249
has exact synonym: vascular network
has_obo_namespace: uberon
id: UBERON:0002049
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

embryonic structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: part of
    some values from: embryo
subclass of: anatomical structure
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: embryo
definition: Anatomical structure that is part of an embryo.
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO]
external_definition: Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO]
external_definition: Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO]
external_ontology_notes: in FMA embryo is_a embryonic structure
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013948
database_cross_reference: C13229
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/667009
database_cross_reference: AAO:0000138
database_cross_reference: BILA:0000034
database_cross_reference: BTO:0000174
database_cross_reference: CALOHA:TS-2110
database_cross_reference: EFO:0000461
database_cross_reference: FBbt:00004208
database_cross_reference: FMA:69067
database_cross_reference: GAID:407
database_cross_reference: MESH:D004628
database_cross_reference: RETIRED_EHDAA2:0003169
database_cross_reference: TAO:0001105
database_cross_reference: UMLS:C0013948
database_cross_reference: VSAO:0000178
database_cross_reference: XAO:0003042
database_cross_reference: ZFA:0001105
has exact synonym: developing embryonic structure
has exact synonym: embryonic anatomical structure
has_obo_namespace: uberon
has_related_synonym: developing structure
has_related_synonym: embryonale Struktur
has_related_synonym: embryonic structures
id: UBERON:0002050
in subset: inconsistent with fma
in subset: vertebrate core
in subset: efo slim

dermis
type: Class
subclass of: mesoderm-derived structure
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
subclass of: integumentary system layer
subclass of: Restriction
  on property: part of
  some values from: skin of body
subclass of: Restriction
  on property: has part
  some values from: collection of collagen fibrils
subclass of: Restriction
  on property: deep_to
  some values from: skin epidermis
subclass of: Restriction
  on property: superficial_to
  some values from: hypodermis
subclass of: Restriction
  on property: has developmental contribution from
  some values from: neural crest
subclass of: Restriction
  on property: composed primarily of
  some values from: connective tissue
subclass of: Restriction
  on property: immediate transformation of
  some values from: future dermis
definition: The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].
editor note: Consider adding a layer-of-skin grouping class for all skin layers
imported from: oae.owl
imported from: uberon.owl
external_definition: A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]
homology_notes: When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]
has_relational_adjective: dermal
database_cross_reference: Dermis
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0011646
database_cross_reference: C12701
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361696001
database_cross_reference: AAO:0000128
database_cross_reference: BTO:0000294
database_cross_reference: CALOHA:TS-2076
database_cross_reference: EFO:0000953
database_cross_reference: EMAPA:17527
database_cross_reference: EV:0100154
database_cross_reference: FMA:70323
database_cross_reference: GAID:1321
database_cross_reference: MA:0000152
database_cross_reference: MAT:0000153
database_cross_reference: MESH:D020405
database_cross_reference: MIAA:0000153
database_cross_reference: TAO:0001119
database_cross_reference: UMLS:C0011646
database_cross_reference: VHOG:0000108
database_cross_reference: XAO:0000217
database_cross_reference: ZFA:0001119
has exact synonym: vertebrate dermis
has_obo_namespace: uberon
has_related_synonym: corium
has_related_synonym: cutis
id: UBERON:0002067
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

hypodermis
type: Class
subclass of: mesoderm-derived structure
subclass of: integumentary system layer
subclass of: Restriction
  on property: part of
  some values from: integument
subclass of: Restriction
  on property: deep_to
  some values from: dermis
subclass of: Restriction
  on property: superficial_to
  some values from: musculature
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
subclass of: Restriction
  on property: composed primarily of
  some values from: adipose tissue
subclass of: Restriction
  on property: composed primarily of
  some values from: loose connective tissue
definition: Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].
imported from: oae.owl
imported from: uberon.owl
external_definition: A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]
external_definition: A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544].
has_relational_adjective: hypodermal
has_relational_adjective: subcutaneous
has_relational_adjective: subcutaneus
external_ontology_notes: BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument.
database_cross_reference: Hypodermis
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0278403
database_cross_reference: C33645
database_cross_reference: BTO:0001314
database_cross_reference: CALOHA:TS-2366
database_cross_reference: FMA:70544
database_cross_reference: TAO:0001136
database_cross_reference: UMLS:C0278403
database_cross_reference: ZFA:0001136
has exact synonym: hypoderm
has exact synonym: vertebrate hypodermis
has_obo_namespace: uberon
has_related_synonym: sub-tegumental tissue
has_related_synonym: subcutaneous tissue
has_related_synonym: subcutis
has_related_synonym: subtegumental tissue
has_related_synonym: superficial fascia
has_related_synonym: tela subcutanea
id: UBERON:0002072
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

postcranial axial skeleton
type: Class
subclass of: mesoderm-derived structure
subclass of: subdivision of skeleton
subclass of: Restriction
  on property: part of
  some values from: axial skeleton plus cranial skeleton
subclass of: Restriction
  on property: part of
  some values from: post-cranial axial skeletal system
subclass of: Restriction
  on property: develops_from
  some values from: sclerotome
definition: The post-cranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA].
imported from: oae.owl
imported from: uberon.owl
external_definition: Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO]
external_definition: The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO]
external_definition: The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO]
homology_notes: The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG]
has_broad_synonym: axial skeleton
database_cross_reference: AAO:0000034
database_cross_reference: EFO:0000942
database_cross_reference: EHDAA2:0000161
database_cross_reference: EHDAA:5049
database_cross_reference: EMAPA:17214
database_cross_reference: FMA:71221
database_cross_reference: MA:0002986
database_cross_reference: MAT:0000148
database_cross_reference: MIAA:0000148
database_cross_reference: TAO:0000317
database_cross_reference: VHOG:0000317
database_cross_reference: VSAO:0000093
database_cross_reference: XAO:0003073
database_cross_reference: ZFA:0000317
has exact synonym: post-cranial axial skeleton
has_obo_namespace: uberon
id: UBERON:0002090
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core
comment: previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed.

skin of body
type: Class
subclass of: organ
subclass of: ectoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: integument
subclass of: Restriction
  on property: develops_from
  some values from: embryonic skin basal layer
subclass of: Restriction
  on property: composed primarily of
  some values from: zone of skin
definition: The organ covering the body that consists of the dermis and epidermis.
curator note: consider 'integumentary system' for invertebrates
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: MA uses the term skin to refer to what is called here: zone of skin
database_cross_reference: Skin
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1123023
database_cross_reference: C12470
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181469002
database_cross_reference: BTO:0001253
database_cross_reference: CALOHA:TS-0934
database_cross_reference: EFO:0000962
database_cross_reference: EHDAA2:0001844
database_cross_reference: EMAPA:17525
database_cross_reference: FMA:7163
database_cross_reference: MESH:D012867
database_cross_reference: MFMO:0000099
database_cross_reference: OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C1123023
database_cross_reference: XAO:0000023
database_cross_reference: galen:Skin
has exact synonym: entire skin
has exact synonym: skin organ
has_obo_namespace: uberon
has_related_synonym: entire integument
has_related_synonym: integument
has_related_synonym: integumental organ
has_related_synonym: pelt
has_related_synonym: skin
id: UBERON:0002097
in subset: major organ
in subset: uberon slim
in subset: efo slim
in subset: pheno slim

trunk
type: Class
subclass of: subdivision of organism along main body axis
subclass of: Restriction
  on property: part of
  some values from: body proper
definition: Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.
imported from: oae.owl
imported from: uberon.owl
external_definition: Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO]
external_definition: Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO]
spatially disjoint from: appendage
spatially disjoint from: head
database_cross_reference: Torso
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0460005
database_cross_reference: C33816
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/262225004
database_cross_reference: AAO:0010339
database_cross_reference: BILA:0000116
database_cross_reference: BTO:0001493
database_cross_reference: CALOHA:TS-1071
database_cross_reference: EFO:0000966
database_cross_reference: EMAPA:31857
database_cross_reference: FMA:7181
database_cross_reference: MA:0000004
database_cross_reference: MAT:0000296
database_cross_reference: MIAA:0000296
database_cross_reference: OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001115
database_cross_reference: UMLS:C0460005
database_cross_reference: XAO:0000054
database_cross_reference: XAO:0003025
database_cross_reference: ZFA:0001115
database_cross_reference: galen:Trunk
has exact synonym: thoracolumbar region
has exact synonym: torso
has exact synonym: trunk region
has_obo_namespace: uberon
has_related_synonym: Rumpf
id: UBERON:0002100
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

hemolymphoid system
type: Class
subclass of: anatomical system
definition: Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: CALOHA:TS-2018
database_cross_reference: EHDAA2:0004615
database_cross_reference: EMAPA:18765
database_cross_reference: FMA:74562
database_cross_reference: MA:0000013
has exact synonym: hematolymphoid system
has exact synonym: lymphomyeloid complex
has_obo_namespace: uberon
has_related_synonym: haemolymphoid system
id: UBERON:0002193

integument
type: Class
subclass of: surface structure
subclass of: organ system subdivision
subclass of: Restriction
  on property: part of
  some values from: integumental system
subclass of: Restriction
  on property: has part
  some values from: hypodermis
subclass of: Restriction
  on property: has part
  some values from: skin of body
subclass of: Restriction
  on property: bounding layer of
  some values from: multicellular organism
definition: The dermis, epidermis and hypodermis.
curator note: in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition.
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO]
external_definition: Surface structure that is the outer protective covering of the body.[VSAO]
external_definition: The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO]
has_relational_adjective: integumental
has_relational_adjective: integumentary
database_cross_reference: Integument
database_cross_reference: AAO:0000239
database_cross_reference: BTO:0000634
database_cross_reference: FMA:74657
database_cross_reference: TAO:0000368
database_cross_reference: VSAO:0000029
database_cross_reference: ZFA:0000368
database_cross_reference: galen:Integument
has exact synonym: dermis plus epidermis plus hypodermis
has exact synonym: integumentum commune
has exact synonym: skin and subcutaneous tissue
has exact synonym: skin plus hypodermis
has exact synonym: the integument
has_obo_namespace: uberon
has_related_synonym: Hautsystem@de
has_related_synonym: dermal system
has_related_synonym: dermoid system
has_related_synonym: skin
has_related_synonym: tegument
has_related_synonym: vertebrate integument
id: UBERON:0002199
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

musculoskeletal system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: has part
  some values from: musculature of body
subclass of: Restriction
  on property: has part
  some values from: skeletal system
subclass of: Restriction
  on property: has developmental contribution from
  some values from: mesoderm
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: Anatomical system that consists of the muscular and skeletal systems.
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical system that provides locomotion and physical support to the organism.[AAO]
homology_notes: There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG]
has_relational_adjective: musculoskeletal
Contributor: cmungall
database_cross_reference: Musculoskeletal system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0026860
database_cross_reference: C12754
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278858007
database_cross_reference: AAO:0010546
database_cross_reference: CALOHA:TS-1311
database_cross_reference: EMAPA:32714
database_cross_reference: EV:0100139
database_cross_reference: FMA:7482
database_cross_reference: GAID:98
database_cross_reference: MA:0002418
database_cross_reference: MESH:D009141
database_cross_reference: OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g
database_cross_reference: UMLS:C0026860
database_cross_reference: VHOG:0001275
database_cross_reference: VSAO:0000031
database_cross_reference: XAO:0000168
has exact synonym: musculo-skeletal system
has_obo_namespace: uberon
id: UBERON:0002204
in subset: uberon slim

synovial joint
type: Class
equivalent class: Class
  intersection of: skeletal joint
  intersection of: Restriction
    on property: surrounded by
    some values from: articular capsule
subclass of: skeletal joint
subclass of: Restriction
  on property: surrounded by
  some values from: articular capsule
definition: Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]
imported from: oae.owl
imported from: uberon.owl
external_definition: Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO]
database_cross_reference: Synovial joint
database_cross_reference: C32461
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/113234001
database_cross_reference: AEO:0000183
database_cross_reference: CALOHA:TS-2138
database_cross_reference: EHDAA2:0003183
database_cross_reference: FMA:7501
database_cross_reference: MA:0000322
database_cross_reference: OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0005153
database_cross_reference: ZFA:0005153
database_cross_reference: galen:SynovialJoint
has exact synonym: articulatio synoviale
has exact synonym: diarthroses
has exact synonym: diarthrosis
has exact synonym: diarthrosis joint
has_obo_namespace: uberon
has_related_synonym: diarthrodial joints
id: UBERON:0002217
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

thoracic cavity
type: Class
equivalent class: Class
  intersection of: anatomical space
  intersection of: Restriction
    on property: part of
    some values from: coelemic cavity lumen
  intersection of: Restriction
    on property: luminal space of
    some values from: thoracic segment of trunk
subclass of: anatomical space
subclass of: Restriction
  on property: part of
  some values from: coelemic cavity lumen
subclass of: Restriction
  on property: luminal space of
  some values from: thoracic segment of trunk
definition: The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.
imported from: oae.owl
imported from: uberon.owl
taxon_notes: In many species, the diaphragm separates thoracic and abdominal cavities
database_cross_reference: Thoracic cavity
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0230139
database_cross_reference: C12905
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/243949006
database_cross_reference: EMAPA:36497
database_cross_reference: FMA:7565
database_cross_reference: GAID:93
database_cross_reference: MA:0000032
database_cross_reference: MESH:A01.911.800
database_cross_reference: OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg
database_cross_reference: OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0230139
has exact synonym: cavitas thoracis
has exact synonym: cavity of chest
has exact synonym: cavity of thorax
has exact synonym: chest cavity
has exact synonym: pectoral cavity
has exact synonym: space of thoracic compartment
has exact synonym: thoracic lumen
has_obo_namespace: uberon
id: UBERON:0002224
in subset: uberon slim
in subset: pheno slim

coelemic cavity lumen
type: Class
subclass of: anatomical cavity
subclass of: Restriction
  on property: transformation of
  some values from: future coelemic cavity lumen
subclass of: Restriction
  on property: luminal space of
  some values from: coelom
definition: The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.
editor note: check the FMA placement here; ncit placement of body cavity here probably not correct
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA].
external_definition: The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO].
taxon_notes: In mammals it forms the peritoneal, pleural, and pericardial cavities
has_alternative_id: UBERON:0000169
has_broad_synonym: body cavity
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0333343
database_cross_reference: C25444
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361348008
database_cross_reference: AEO:0000186
database_cross_reference: BTO:0001707
database_cross_reference: EHDAA2:0000267
database_cross_reference: FBbt:00005060
database_cross_reference: FMA:85006
database_cross_reference: RETIRED_EHDAA2:0003186
database_cross_reference: TAO:0001438
database_cross_reference: UMLS:C0333343
database_cross_reference: ZFA:0001438
database_cross_reference: galen:BodyCavity
has exact synonym: coelomic cavity
has exact synonym: coelomic cavity lumen
has exact synonym: main body cavity
has exact synonym: space of body compartment
has_narrow_synonym: ventral body cavity
has_obo_namespace: uberon
has_related_synonym: celom
has_related_synonym: coelom
has_related_synonym: coelome
has_related_synonym: hemocoel
id: UBERON:0002323
in subset: uberon slim
in subset: vertebrate core

notochord
type: Class
subclass of: multi-tissue structure
subclass of: mesoderm-derived structure
subclass of: ectoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: axial skeletal system
subclass of: Restriction
  on property: dorsal_to
  some values from: digestive tract
subclass of: Restriction
  on property: ventral_to
  some values from: neural tube
subclass of: Restriction
  on property: develops_from
  some values from: chordamesoderm
subclass of: Restriction
  on property: develops_from
  some values from: notochordal plate
subclass of: Restriction
  on property: existence starts during
  some values from: embryo stage
definition: A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube.
imported from: oae.owl
imported from: uberon.owl
external_definition: Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]
external_definition: Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]
external_definition: Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]
axiom_lost_from_external_ontology: relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO]
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG]
has_relational_adjective: notochordal
development_notes: In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord.
Contributor: cmungall
Contributor: wdahdul
database_cross_reference: Notochord
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0028439
database_cross_reference: C12463
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/308820002
database_cross_reference: AAO:0000327
database_cross_reference: BTO:0001768
database_cross_reference: CALOHA:TS-0690
database_cross_reference: EHDAA2:0001277
database_cross_reference: EHDAA:1241
database_cross_reference: EHDAA:6021
database_cross_reference: EMAPA:16191
database_cross_reference: EV:0100002
database_cross_reference: FMA:85521
database_cross_reference: GAID:1311
database_cross_reference: MAT:0000281
database_cross_reference: MESH:A16.254.610
database_cross_reference: TAO:0000135
database_cross_reference: UMLS:C0028439
database_cross_reference: VHOG:0000199
database_cross_reference: VSAO:0000032
database_cross_reference: XAO:0000055
database_cross_reference: ZFA:0000135
has exact synonym: embryonic notocord
has exact synonym: notocord
has_obo_namespace: uberon
has_related_synonym: notochorda
id: UBERON:0002328
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim
comment: The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB]

somite
type: Class
subclass of: developing anatomical structure
subclass of: epithelial vesicle
subclass of: meso-epithelium
subclass of: Restriction
  on property: develops_from
  some values from: presomitic mesoderm
definition: Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
editor note: currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
imported from: oae.owl
imported from: uberon.owl
never in taxon: NCBITaxon 7712
external_definition: Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]
external_definition: Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]
axiom_lost_from_external_ontology: relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO]
axiom_lost_from_external_ontology: relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO]
axiom_lost_from_external_ontology: relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO]
homology_notes: (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG]
has_relational_adjective: somitic
has_broad_synonym: mesodermal cluster
database_cross_reference: Somite
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0376449
database_cross_reference: C34302
database_cross_reference: AAO:0010569
database_cross_reference: AEO:0001015
database_cross_reference: BTO:0001558
database_cross_reference: EHDAA2:0003436
database_cross_reference: EHDAA:366
database_cross_reference: EHDAA:699
database_cross_reference: EMAPA:31169
database_cross_reference: FMA:85522
database_cross_reference: GAID:1306
database_cross_reference: MAT:0000068
database_cross_reference: MESH:A16.254.425.660.750
database_cross_reference: MIAA:0000068
database_cross_reference: TAO:0000155
database_cross_reference: UMLS:C0376449
database_cross_reference: VHOG:0000191
database_cross_reference: XAO:0000058
database_cross_reference: ZFA:0000155
has_obo_namespace: uberon
has_related_synonym: epimere
has_related_synonym: epimere mesoderm
has_related_synonym: epithelial somite
has_related_synonym: somites
has_related_synonym: somitic mesoderm
has_related_synonym: somitus
id: UBERON:0002329
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim
comment: When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248]

exocrine system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: composed primarily of
  some values from: exocrine gland
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia].
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Exocrine gland
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1516995
database_cross_reference: C12957
database_cross_reference: CALOHA:TS-2057
database_cross_reference: EHDAA2:0002225
database_cross_reference: EMAPA:35329
database_cross_reference: FMA:85539
database_cross_reference: MA:0002411
database_cross_reference: UMLS:C1516995
database_cross_reference: WikipediaCategory:Exocrine_system
has exact synonym: exocrine glandular system
has_obo_namespace: uberon
id: UBERON:0002330
in subset: uberon slim
in subset: pheno slim

neural crest
type: Class
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
subclass of: germ layer / neural crest
subclass of: Restriction
  on property: part of
  some values from: neurectoderm
subclass of: Restriction
  on property: develops_from
  some values from: neural plate
subclass of: Restriction
  on property: develops_from
  some values from: neural fold
subclass of: Restriction
  on property: existence starts during
  some values from: neurula stage
definition: A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
editor note: consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
imported from: oae.owl
imported from: uberon.owl
dubious_for_taxon: NCBITaxon_117565
external_definition: A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]
external_definition: Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO]
homology_notes: A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831]
homology_notes: We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG]
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Neural crest
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0027789
database_cross_reference: C34222
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361462002
database_cross_reference: AAO:0010578
database_cross_reference: BTO:0001764
database_cross_reference: CALOHA:TS-0676
database_cross_reference: EHDAA2:0004419
database_cross_reference: EMAPA:32737
database_cross_reference: FMA:86666
database_cross_reference: GAID:1310
database_cross_reference: MAT:0000066
database_cross_reference: MESH:A16.254.600
database_cross_reference: MIAA:0000066
database_cross_reference: TAO:0000045
database_cross_reference: UMLS:C0027789
database_cross_reference: VHOG:0000057
database_cross_reference: XAO:0000048
database_cross_reference: ZFA:0000045
has exact synonym: NC
has_obo_namespace: uberon
has_related_synonym: crista neuralis
has_related_synonym: neural crest material
id: UBERON:0002342
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim
comment: Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells.

neurectoderm
type: Class
subclass of: germ layer
subclass of: ectoderm-derived structure
subclass of: Restriction
  on property: develops_from
  some values from: ectoderm
definition: Embryonic ectoderm that gives rise to nervous tissue.
imported from: oae.owl
imported from: uberon.owl
homology_notes: (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG]
has_relational_adjective: neurectodermal
terminology_notes: we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here
database_cross_reference: Neuroectoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1518271
database_cross_reference: C34228
database_cross_reference: AAO:0011074
database_cross_reference: BILA:0000039
database_cross_reference: CALOHA:TS-1212
database_cross_reference: EHDAA2:0001248
database_cross_reference: EHDAA:1498
database_cross_reference: EHDAA:255
database_cross_reference: EMAPA:16073
database_cross_reference: EV:0100004
database_cross_reference: FBbt:00001061
database_cross_reference: FMA:87657
database_cross_reference: MAT:0000176
database_cross_reference: MIAA:0000176
database_cross_reference: TAO:0001120
database_cross_reference: UMLS:C1518271
database_cross_reference: VHOG:0000150
database_cross_reference: XAO:0000042
database_cross_reference: ZFA:0001120
has exact synonym: neural ectoderm
has exact synonym: neuroectoderm
has_obo_namespace: uberon
has_related_synonym: epithelium tubi neuralis; neuroectoderma
has_related_synonym: neuaral ectoderm
has_related_synonym: presumptive central nervous system
has_related_synonym: ventral neurogenic region
id: UBERON:0002346
in subset: uberon slim
in subset: vertebrate core

exocrine gland
type: Class
equivalent class: Class
  intersection of: gland
  intersection of: Restriction
    on property: part of
    some values from: exocrine system
subclass of: gland
subclass of: Restriction
  on property: part of
  some values from: exocrine system
subclass of: Restriction
  on property: has part
  some values from: duct
definition: A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas
editor note: Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Exocrine gland
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0015282
database_cross_reference: C12712
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/115976003
database_cross_reference: AEO:0000097
database_cross_reference: BTO:0000765
database_cross_reference: CALOHA:TS-2012
database_cross_reference: EHDAA2:0003097
database_cross_reference: EMAPA:35327
database_cross_reference: FMA:9596
database_cross_reference: GAID:34
database_cross_reference: MA:0002564
database_cross_reference: MESH:D005088
database_cross_reference: UMLS:C0015282
has exact synonym: ducted gland
has exact synonym: glandula exocrina
has_obo_namespace: uberon
id: UBERON:0002365
in subset: organ slim
in subset: uberon slim
in subset: pheno slim

connective tissue
type: Class
subclass of: tissue
definition: Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.
imported from: oae.owl
imported from: uberon.owl
external_definition: One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO]
external_definition: Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO]
external_definition: Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO]
external_ontology_notes: MA also has set of connective tissues
Contributor: cmungall
Contributor: wdahdul
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0009780
database_cross_reference: C12374
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361919005
database_cross_reference: AAO:0000098
database_cross_reference: BTO:0000421
database_cross_reference: CALOHA:TS-2009
database_cross_reference: EFO:0000952
database_cross_reference: EMAPA:35251
database_cross_reference: FMA:9640
database_cross_reference: GAID:100
database_cross_reference: MA:0000011
database_cross_reference: MAT:0000301
database_cross_reference: MESH:D003238
database_cross_reference: MIAA:0000301
database_cross_reference: OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001641
database_cross_reference: UMLS:C0009780
database_cross_reference: VSAO:0000017
database_cross_reference: XAO:0001017
database_cross_reference: ZFA:0001632
database_cross_reference: galen:ConnectiveTissue
has exact synonym: portion of connective tissue
has exact synonym: textus connectivus
has_obo_namespace: uberon
has_related_synonym: Bindegewebe
id: UBERON:0002384
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

muscle tissue
type: Class
subclass of: tissue
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: musculature
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
definition: Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].
imported from: oae.owl
imported from: uberon.owl
external_definition: One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO]
spatially disjoint from: neural tissue
database_cross_reference: Muscle tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C2328219
database_cross_reference: C12435
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91727004
database_cross_reference: AAO:0000306
database_cross_reference: AEO:0000122
database_cross_reference: CALOHA:TS-0642
database_cross_reference: EHDAA2:0003122
database_cross_reference: EMAPA:32715
database_cross_reference: FMA:9641
database_cross_reference: MA:0002437
database_cross_reference: MESH:D009132
database_cross_reference: UMLS:C2328219
database_cross_reference: galen:MuscleTissue
has exact synonym: muscular tissue
has exact synonym: portion of muscle tissue
has exact synonym: textus muscularis
has_obo_namespace: uberon
id: UBERON:0002385
in subset: uberon slim
comment: Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach.

hematopoietic system
type: Class
subclass of: anatomical system
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: hemolymphoid system
subclass of: Restriction
  on property: develops_from
  some values from: blood island
definition: Anatomical system that is involved in the production of hematopoietic cells.
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical system that consists of the blood and blood forming tissues.[AAO]
homology_notes: Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG]
has_relational_adjective: hematopoietic
taxon_notes: In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes
database_cross_reference: Haematopoiesis
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0018957
database_cross_reference: C12909
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362587009
database_cross_reference: AAO:0011002
database_cross_reference: BTO:0000570
database_cross_reference: CALOHA:TS-0449
database_cross_reference: EFO:0000798
database_cross_reference: EMAPA:35402
database_cross_reference: EV:0100045
database_cross_reference: FMA:9667
database_cross_reference: GAID:1008
database_cross_reference: MA:0002434
database_cross_reference: MAT:0000022
database_cross_reference: MESH:D006413
database_cross_reference: MIAA:0000022
database_cross_reference: TAO:0005023
database_cross_reference: UMLS:C0018957
database_cross_reference: VHOG:0001624
database_cross_reference: XAO:0000122
database_cross_reference: ZFA:0005023
has exact synonym: haematological system
has exact synonym: haemopoietic system
has exact synonym: organa haemopoietica
has_obo_namespace: uberon
has_related_synonym: Blutbildungssystem
has_related_synonym: haematopoietic system
has_related_synonym: hematological system
has_related_synonym: hematolymphoid system
has_related_synonym: hemopoietic system
id: UBERON:0002390
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

integumental system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: has part
  some values from: outer epithelium
subclass of: Restriction
  on property: bounding layer of
  some values from: multicellular organism
subclass of: Restriction
  on property: surrounded by
  some values from: space surrounding organism
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.
imported from: oae.owl
imported from: uberon.owl
homology_notes: (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG]
Contributor: cmungall
Contributor: tfhayamizu
has_alternative_id: UBERON:0007029
database_cross_reference: Integumentary system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0037267
database_cross_reference: C12907
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361692004
database_cross_reference: AEO:0000154
database_cross_reference: BILA:0000118
database_cross_reference: CALOHA:TS-1299
database_cross_reference: CARO:0002001
database_cross_reference: EFO:0000807
database_cross_reference: EHDAA2:0000836
database_cross_reference: EHDAA2_RETIRED:0003154
database_cross_reference: EHDAA:6520
database_cross_reference: EMAPA:17524
database_cross_reference: EV:0100151
database_cross_reference: FBbt:00004969
database_cross_reference: FMA:72979
database_cross_reference: HAO:0000421
database_cross_reference: MA:0000014
database_cross_reference: MAT:0000033
database_cross_reference: MESH:D034582
database_cross_reference: MIAA:0000033
database_cross_reference: TADS:0000108
database_cross_reference: UMLS:C0037267
database_cross_reference: VHOG:0000403
database_cross_reference: XAO:0000176
database_cross_reference: galen:Surface
has exact synonym: integumentary system
has_obo_namespace: uberon
has_related_synonym: body surface
has_related_synonym: dermal system
has_related_synonym: external covering of organism
has_related_synonym: integumentum commune
has_related_synonym: organism surface
has_related_synonym: surface
id: UBERON:0002416
in subset: grouping class
in subset: efo slim
in subset: pheno slim

abdominal segment of trunk
type: Class
subclass of: subdivision of trunk
subclass of: subdivision of organism along main body axis
definition: The abdominal segment of the torso.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Lumbar
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362875007
database_cross_reference: EMAPA:35104
database_cross_reference: FMA:259211
database_cross_reference: MA:0000021
has_obo_namespace: uberon
has_related_synonym: abdomen/pelvis/perineum
has_related_synonym: lower body
has_related_synonym: lower trunk
has_related_synonym: lumbar region
id: UBERON:0002417

bone tissue
type: Class
subclass of: skeletal tissue
subclass of: Restriction
  on property: part of
  some values from: bone element
definition: Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.
editor note: see https://github.com/obophenotype/uberon/issues/27
imported from: oae.owl
imported from: uberon.owl
external_definition: Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO]
database_cross_reference: Bone tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0391978
database_cross_reference: C13076
database_cross_reference: CALOHA:TS-2011
database_cross_reference: EMAPA:35179
database_cross_reference: FMA:224804
database_cross_reference: MA:0002780
database_cross_reference: MESH:D001842
database_cross_reference: UMLS:C0391978
database_cross_reference: VSAO:0000047
database_cross_reference: XAO:0004040
database_cross_reference: ZFA:0005621
database_cross_reference: galen:BoneTissue
has exact synonym: calcium tissue
has exact synonym: osseous tissue
has exact synonym: osteogenic tissue
has_narrow_synonym: mineralized bone tissue
has_obo_namespace: uberon
has_related_synonym: bone
has_related_synonym: portion of bone tissue
id: UBERON:0002481
in subset: uberon slim
in subset: pheno slim

gland
type: Class
subclass of: organ
subclass of: Restriction
  on property: produces
  some values from: organism substance
definition: an organ that functions as a secretory or excretory organ
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: glandular
has_alternative_id: UBERON:MIAA_0000021
database_cross_reference: Gland
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1285092
database_cross_reference: C13319
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/134358001
database_cross_reference: AAO:0000212
database_cross_reference: AEO:0000096
database_cross_reference: BTO:0000522
database_cross_reference: EFO:0000797
database_cross_reference: EHDAA2:0003096
database_cross_reference: EHDAA:2161
database_cross_reference: EHDAA:4475
database_cross_reference: EHDAA:6522
database_cross_reference: EMAPA:18425
database_cross_reference: FBbt:00100317
database_cross_reference: FMA:7146
database_cross_reference: FMA:86294
database_cross_reference: HAO:0000375
database_cross_reference: MA:0003038
database_cross_reference: MAT:0000021
database_cross_reference: MIAA:0000021
database_cross_reference: OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C1285092
database_cross_reference: WikipediaCategory:Glands
database_cross_reference: galen:Gland
has exact synonym: glandular organ
has_obo_namespace: uberon
has_related_synonym: Druese
has_related_synonym: glandula
id: UBERON:0002530
in subset: uberon slim
in subset: efo slim
in subset: pheno slim

epiblast (generic)
type: Class
subclass of: embryonic structure
definition: In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]
editor note: MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class
imported from: oae.owl
imported from: uberon.owl
homology_notes: In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]
database_cross_reference: Epiblast
database_cross_reference: BTO:0004593
database_cross_reference: FMA:296704
database_cross_reference: MAT:0000067
database_cross_reference: MIAA:0000067
database_cross_reference: VHOG:0000243
has exact synonym: epiblast
has_obo_namespace: uberon
has_related_synonym: blastocyst
has_related_synonym: ectoblast
has_related_synonym: epiblastus
has_related_synonym: primitive ectoderm
id: UBERON:0002532
in subset: early development
in subset: grouping class
in subset: uberon slim
in subset: vertebrate core

anatomical cavity
type: Class
subclass of: anatomical space
subclass of: Restriction
  on property: location_of
  some values from: organism substance
definition: Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: cavity
database_cross_reference: C34007
database_cross_reference: birnlex 1011
database_cross_reference: FMA:67552
database_cross_reference: MA:0002447
database_cross_reference: galen:Cavity
has_obo_namespace: uberon
id: UBERON:0002553
in subset: upper level

periderm
type: Class
subclass of: simple squamous epithelium
subclass of: ecto-epithelium
subclass of: Restriction
  on property: part of
  some values from: integument
subclass of: Restriction
  on property: develops_from
  some values from: external ectoderm
subclass of: Restriction
  on property: develops_from
  some values from: enveloping layer of ectoderm
definition: A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis.
imported from: oae.owl
imported from: uberon.owl
external_definition: The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO]
axiom_lost_from_external_ontology: relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO]
taxon_notes: In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP]
development_notes: In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis
development_notes: Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1518973
database_cross_reference: C34247
database_cross_reference: EHDAA2:0001846
database_cross_reference: EHDAA:6538
database_cross_reference: FMA:295662
database_cross_reference: TAO:0001185
database_cross_reference: UMLS:C1518973
database_cross_reference: VHOG:0001680
database_cross_reference: XAO:0000029
database_cross_reference: ZFA:0001185
has exact synonym: skin periderm
has_obo_namespace: uberon
has_related_synonym: EVL
has_related_synonym: epidermis epithelial layer
has_related_synonym: epidermis outer layer
has_related_synonym: epitrichium
has_related_synonym: periderm
id: UBERON:0003055
in subset: uberon slim
in subset: pheno slim

presomitic mesoderm
type: Class
equivalent class: Class
  intersection of: developing anatomical structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: somite
  intersection of: Restriction
    on property: immediate transformation of
    some values from: presumptive segmental plate
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: paraxial mesoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: somite
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive segmental plate
definition: Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
imported from: oae.owl
imported from: uberon.owl
external_definition: Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
homology_notes: It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
database_cross_reference: AAO:0011086
database_cross_reference: EFO:0001982
database_cross_reference: EMAPA:16189
database_cross_reference: EMAPA:16752
database_cross_reference: TAO:0000279
database_cross_reference: VHOG:0000559
database_cross_reference: XAO:0000057
database_cross_reference: ZFA:0000279
has exact synonym: segmental plate
has exact synonym: unsegmented paraxial mesoderm
has_obo_namespace: uberon
has_related_synonym: PSM
has_related_synonym: presumptive somite mesoderm
has_related_synonym: somitogenic mesoderm
has_related_synonym: somitomeric mesoderm
has_related_synonym: unsegmented mesenchyme
id: UBERON:0003059
in subset: efo slim
in subset: pheno slim

blood island
type: Class
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: lateral plate mesoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: hematopoietic system
definition: Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted].
imported from: oae.owl
imported from: uberon.owl
external_definition: Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO]
external_definition: Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO]
axiom_lost_from_external_ontology: relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO]
homology_notes: Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG]
external_ontology_notes: EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac
has_broad_synonym: ventral lateral plate mesoderm
database_cross_reference: Blood island of umbilical vesicle
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1511224
database_cross_reference: C34113
database_cross_reference: AAO:0011006
database_cross_reference: EFO:0003489
database_cross_reference: EHDAA:207
database_cross_reference: TAO:0000094
database_cross_reference: TE:E5.11.2.0.0.0.4
database_cross_reference: UMLS:C1511224
database_cross_reference: VHOG:0000085
database_cross_reference: XAO:0000067
database_cross_reference: ZFA:0000094
has exact synonym: blood islands
has_obo_namespace: uberon
has_related_synonym: VBI
has_related_synonym: caudal hematopoietic tissue
has_related_synonym: posterior ICM
has_related_synonym: posterior blood island
has_related_synonym: ventral blood island
id: UBERON:0003061
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

axial mesoderm
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: part of
  some values from: mesoderm
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
definition: The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.
imported from: oae.owl
imported from: uberon.owl
external_definition: The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]
database_cross_reference: Chordamesoderm
database_cross_reference: AAO:0011017
database_cross_reference: EFO:0003647
database_cross_reference: TAO:0001204
database_cross_reference: VHOG:0000107
database_cross_reference: XAO:0000205
database_cross_reference: ZFA:0001204
has_obo_namespace: uberon
has_related_synonym: chordamesoderm
id: UBERON:0003068
in subset: uberon slim
in subset: efo slim

neural plate
type: Class
subclass of: embryonic tissue
subclass of: ecto-epithelium
subclass of: future central nervous system
subclass of: Restriction
  on property: developmentally_induced_by
  some values from: notochord
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive neural plate
definition: A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]
imported from: oae.owl
imported from: uberon.owl
external_definition: The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Neural plate
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0920623
database_cross_reference: C34225
database_cross_reference: AAO:0011072
database_cross_reference: BTO:0001765
database_cross_reference: DHBA:10153
database_cross_reference: DMBA:15565
database_cross_reference: EHDAA:346
database_cross_reference: EHDAA:902
database_cross_reference: EMAPA:35593
database_cross_reference: FMA:293879
database_cross_reference: RETIRED_EHDAA2:0001252
database_cross_reference: TAO:0000132
database_cross_reference: UMLS:C0920623
database_cross_reference: VHOG:0000068
database_cross_reference: XAO:0000249
database_cross_reference: ZFA:0000132
has_obo_namespace: uberon
has_related_synonym: lamina neuralis
has_related_synonym: presumptive central nervous system
id: UBERON:0003075
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

paraxial mesoderm
type: Class
subclass of: mesoderm-derived structure
subclass of: embryonic tissue
subclass of: dense mesenchyme tissue
subclass of: lateral structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: in_lateral_side_of
  some values from: embryo
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive paraxial mesoderm
definition: The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]
imported from: oae.owl
imported from: uberon.owl
external_definition: Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
homology_notes: Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
external_ontology_notes: note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)
database_cross_reference: Paraxial mesoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1284009
database_cross_reference: C34244
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361475002
database_cross_reference: AAO:0010568
database_cross_reference: EFO:0003515
database_cross_reference: EMAPA:16183
database_cross_reference: EMAPA:16751
database_cross_reference: FMA:293145
database_cross_reference: TAO:0000255
database_cross_reference: UMLS:C1284009
database_cross_reference: VHOG:0000114
database_cross_reference: XAO:0000259
database_cross_reference: ZFA:0000255
has exact synonym: paraxial mesenchyme
has exact synonym: somitic mesoderm
has_obo_namespace: uberon
has_related_synonym: mesoderma paraxiale
id: UBERON:0003077
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim

lateral plate mesoderm
type: Class
subclass of: mesoderm-derived structure
subclass of: embryonic tissue
subclass of: dense mesenchyme tissue
subclass of: Restriction
  on property: part of
  some values from: mesoderm
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
subclass of: Restriction
  on property: surrounds
  some values from: intraembryonic coelom
definition: Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].
imported from: oae.owl
imported from: uberon.owl
external_definition: Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]
external_definition: The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]
homology_notes: A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]
external_ontology_notes: subclass of mesoderm in ZFA.
has_alternative_id: UBERON:0006258
database_cross_reference: Lateral plate mesoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1517749
database_cross_reference: C34199
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361477005
database_cross_reference: AAO:0010574
database_cross_reference: EHDAA2:0000919
database_cross_reference: EHDAA:379
database_cross_reference: EMAPA:16179
database_cross_reference: FMA:293149
database_cross_reference: TAO:0000121
database_cross_reference: UMLS:C1517749
database_cross_reference: VHOG:0000118
database_cross_reference: XAO:0000311
database_cross_reference: ZFA:0000121
has exact synonym: LPM
has exact synonym: lateral mesoderm
has_obo_namespace: uberon
has_related_synonym: lateral plate
has_related_synonym: lateral plate mesenchyme
has_related_synonym: mesoderma laminae lateralis
id: UBERON:0003081
in subset: uberon slim
in subset: pheno slim

heart primordium
type: Class
subclass of: primordium
subclass of: Restriction
  on property: part of
  some values from: cardiovascular system
subclass of: Restriction
  on property: develops_from
  some values from: lateral plate mesoderm
subclass of: Restriction
  on property: develops_from
  some values from: primary heart field
subclass of: Restriction
  on property: develops_from
  some values from: cardiac mesoderm
definition: Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
editor note: should probably be merged with heart rudiment.
imported from: oae.owl
imported from: uberon.owl
external_definition: Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
external_definition: The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO]
axiom_lost_from_external_ontology: relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO]
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1514450
database_cross_reference: C34276
database_cross_reference: AAO:0011044
database_cross_reference: BTO:0001887
database_cross_reference: TAO:0000028
database_cross_reference: UMLS:C1514450
database_cross_reference: XAO:0000336
database_cross_reference: ZFA:0000028
has_obo_namespace: uberon
has_related_synonym: cardiac field
has_related_synonym: fused heart primordium
id: UBERON:0003084
in subset: uberon slim

sclerotome
type: Class
subclass of: mesoderm-derived structure
subclass of: developing mesenchymal condensation
subclass of: migrating mesenchyme population
subclass of: Restriction
  on property: develops_from
  some values from: somite
definition: Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
imported from: oae.owl
imported from: uberon.owl
external_definition: Skeletogenic portion of somites.[AAO]
homology_notes: The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
external_ontology_notes: part_of somite in XAO
database_cross_reference: Sclerotome
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0183176
database_cross_reference: C34287
database_cross_reference: AAO:0010571
database_cross_reference: AEO:0000212
database_cross_reference: EHDAA2:0003439
database_cross_reference: EMAPA:31159
database_cross_reference: FMA:295652
database_cross_reference: TAO:0001080
database_cross_reference: UMLS:C0183176
database_cross_reference: VHOG:0000680
database_cross_reference: XAO:0000397
database_cross_reference: ZFA:0001080
has exact synonym: sclerotomes
has_obo_namespace: uberon
has_related_synonym: sclerotomus
id: UBERON:0003089
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

surface structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: part of
    some values from: integumental system
  intersection of: Restriction
    on property: adjacent_to
    some values from: space surrounding organism
subclass of: anatomical structure
subclass of: Restriction
  on property: part of
  some values from: integumental system
subclass of: Restriction
  on property: has part
  some values from: Restriction
    on property: part of
    some values from: outer epithelium
subclass of: Restriction
  on property: adjacent_to
  some values from: space surrounding organism
definition: Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.
imported from: oae.owl
imported from: uberon.owl
external_definition: Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA]
Contributor: cmungall
Contributor: wdahdul
database_cross_reference: Surface structure
database_cross_reference: AAO:0010337
database_cross_reference: AEO_RETIRED:0000010
database_cross_reference: EHDAA2_RETIRED:0003010
database_cross_reference: TAO:0000292
database_cross_reference: VSAO:0000001
database_cross_reference: XAO:0003028
database_cross_reference: ZFA:0000292
database_cross_reference: galen:SurfaceRegion
has exact synonym: anatomical surface feature
has_obo_namespace: uberon
has_related_synonym: surface feature
has_related_synonym: surface region
has_related_synonym: surface structures
id: UBERON:0003102
in subset: upper level

compound organ
type: Class
subclass of: organ
definition: Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.
curator note: this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0010015
database_cross_reference: AEO:0000024
database_cross_reference: BILA:0000024
database_cross_reference: CARO:0000024
database_cross_reference: EHDAA2:0003024
database_cross_reference: HAO:0000024
database_cross_reference: TADS:0000598
database_cross_reference: TAO:0000496
database_cross_reference: TGMA:0001837
database_cross_reference: VHOG:0001723
database_cross_reference: XAO:0003041
database_cross_reference: ZFA:0000496
has_obo_namespace: uberon
has_related_synonym: organ
id: UBERON:0003103
in subset: organ slim
in subset: upper level

mesenchyme
type: Class
subclass of: tissue
subclass of: Restriction
  on property: has developmental contribution from
  some values from: mesoderm
definition: Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO].
editor note: the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense
imported from: oae.owl
imported from: uberon.owl
external_definition: A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]
external_definition: Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]
has_relational_adjective: mesenchymal
database_cross_reference: Mesenchyme
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0162415
database_cross_reference: C13301
database_cross_reference: AAO:0010427
database_cross_reference: AEO:0000145
database_cross_reference: BTO:0001393
database_cross_reference: CALOHA:TS-0620
database_cross_reference: EHDAA2:0003145
database_cross_reference: EV:0100007
database_cross_reference: TAO:0000393
database_cross_reference: UMLS:C0162415
database_cross_reference: VHOG:0000170
database_cross_reference: XAO:0003046
database_cross_reference: ZFA:0000393
has exact synonym: mesenchymal tissue
has exact synonym: mesenchyme tissue
has exact synonym: portion of mesenchymal tissue
has exact synonym: portion of mesenchyme tissue
has_obo_namespace: uberon
has_related_synonym: mesenchyma
id: UBERON:0003104
in subset: uberon slim
in subset: vertebrate core
in subset: pheno slim

neural tissue
type: Class
subclass of: tissue
subclass of: Restriction
  on property: part of
  some values from: nervous system
definition: Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.
imported from: oae.owl
imported from: uberon.owl
external_definition: One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO]
external_ontology_notes: FMA definition includes vasculature
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0027757
database_cross_reference: C13052
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91728009
database_cross_reference: AAO:0000325
database_cross_reference: AEO:0000123
database_cross_reference: EHDAA2:0003123
database_cross_reference: FMA:9642
database_cross_reference: GAID:609
database_cross_reference: MESH:D009417
database_cross_reference: OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ
database_cross_reference: UMLS:C0027757
has exact synonym: nerve tissue
has exact synonym: nervous tissue
has exact synonym: portion of neural tissue
has_obo_namespace: uberon
id: UBERON:0003714

future coelemic cavity lumen
type: Class
equivalent class: Class
  intersection of: anatomical space
  intersection of: Restriction
    on property: has potential to develop into
    some values from: coelemic cavity lumen
subclass of: anatomical space
subclass of: Restriction
  on property: located_in
  some values from: mesoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: coelemic cavity lumen
subclass of: Restriction
  on property: existence starts during
  some values from: gastrula stage
subclass of: Restriction
  on property: existence ends during
  some values from: organogenesis stage
definition: An anatomical cavity that has the potential to develop into a coelemic cavity lumen.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
has_related_synonym: body cavity precursor
id: UBERON:0003886
in subset: grouping class
in subset: non informative

intraembryonic coelom
type: Class
subclass of: embryonic structure
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: coelom
subclass of: Restriction
  on property: develops_from
  some values from: lateral plate mesoderm
definition: The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom
editor note: consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
imported from: oae.owl
imported from: uberon.owl
homology_notes: (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
database_cross_reference: Intraembryonic coelom
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1512940
database_cross_reference: C34195
database_cross_reference: EHDAA:251
database_cross_reference: EMAPA:16088
database_cross_reference: UMLS:C1512940
database_cross_reference: VHOG:0000316
has exact synonym: somatic coelom
has_obo_namespace: uberon
id: UBERON:0003887
in subset: pheno slim

epithelial tube
type: Class
subclass of: tube
subclass of: epithelium
definition: Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
curator note: contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO:0000114
database_cross_reference: EHDAA2:0003114
database_cross_reference: FBbt:00007474
has exact synonym: epithelial or endothelial tube
has_obo_namespace: uberon
id: UBERON:0003914

dermatome
type: Class
subclass of: developing mesenchymal structure
subclass of: Restriction
  on property: develops_from
  some values from: somite
subclass of: Restriction
  on property: develops_from
  some values from: dermomyotome
definition: A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.
imported from: oae.owl
imported from: uberon.owl
terminology_notes: Not to be confused with 'dermatome segment of skin'.
database_cross_reference: Dermatome (embryology)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0180383
database_cross_reference: C61572
database_cross_reference: AAO:0011028
database_cross_reference: AEO:0001017
database_cross_reference: EHDAA2_RETIRED:0003428
database_cross_reference: EHDAA:1719
database_cross_reference: EHDAA:1725
database_cross_reference: EHDAA:1731
database_cross_reference: EHDAA:1737
database_cross_reference: EMAPA:32838
database_cross_reference: FMA:295656
database_cross_reference: UMLS:C0180383
database_cross_reference: XAO:0000220
has exact synonym: cutis plate
has exact synonym: dermatomal mesenchyme
has_obo_namespace: uberon
has_related_synonym: epimere mesoderm
has_related_synonym: mesenchyma dermatomiale
id: UBERON:0004016
in subset: pheno slim

anatomical conduit
type: Class
equivalent class: Class
  intersection of: multicellular anatomical structure
  intersection of: Restriction
    on property: has part
    some values from: anatomical conduit space
  intersection of: Restriction
    on property: conduit for
    some values from: anatomical structure
subclass of: multicellular anatomical structure
subclass of: Class
  intersection of: Restriction
    on property: connects
    min qualified cardinality: 2
    on class: anatomical space
  intersection of: Restriction
    on property: connects
    max qualified cardinality: 2
    on class: anatomical space
subclass of: Restriction
  on property: has part
  some values from: anatomical conduit space
subclass of: Restriction
  on property: conduit for
  some values from: anatomical structure
definition: Any tube, opening or passage that connects two distinct anatomical spaces.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: FMA has both conduit and conduit space. In EHDAA2 this is a surface feature
database_cross_reference: Foramen
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/346902003
database_cross_reference: AEO:0000080
database_cross_reference: EHDAA2:0003080
database_cross_reference: FMA:242873
has_narrow_synonym: foramen
has_narrow_synonym: foramina
has_obo_namespace: uberon
has_related_synonym: opening
has_related_synonym: ostia
has_related_synonym: ostium
id: UBERON:0004111

mesoderm-derived structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: develops_from
    some values from: mesoderm
subclass of: anatomical structure
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
definition: An anatomical structure that develops (entirely or partially) from the mesoderm.
curator note: Grouping term for query purposes
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0004120
in subset: grouping class

ectoderm-derived structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: develops_from
    some values from: ectoderm
subclass of: anatomical structure
subclass of: Restriction
  on property: develops_from
  some values from: ectoderm
definition: An anatomical structure that develops (entirely or partially) from the ectoderm.
curator note: Grouping term for query purposes
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0004121
in subset: grouping class

cardiogenic plate
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: heart primordium
definition: The first recognizable structure derived from the heart field
editor note: TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO
imported from: oae.owl
imported from: uberon.owl
homology_notes: (In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG]
database_cross_reference: EHDAA2:0000215
database_cross_reference: EMAPA:16106
database_cross_reference: VHOG:0000975
has exact synonym: myocardial plate
has_obo_namespace: uberon
has_related_synonym: cardiac crescent
has_related_synonym: cardiogenic crescent
has_related_synonym: heart rudiment
id: UBERON:0004139
in subset: pheno slim

primary heart field
type: Class
subclass of: mesoderm-derived structure
subclass of: embryonic tissue
subclass of: anlage
subclass of: Restriction
  on property: part of
  some values from: lateral plate mesoderm
definition: A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
database_cross_reference: XAO:0004185
has exact synonym: first heart field
has exact synonym: primary heart field
has_obo_namespace: uberon
has_related_synonym: FHF
has_related_synonym: PHF
has_related_synonym: heart field
id: UBERON:0004140

heart tube
type: Class
subclass of: epithelial tube
subclass of: embryonic tissue
subclass of: meso-epithelium
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: immediate transformation of
  some values from: primitive heart tube
definition: An epithelial tube that will give rise to the mature heart.
imported from: oae.owl
imported from: uberon.owl
external_definition: the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
database_cross_reference: C34161
database_cross_reference: AAO:0010411
database_cross_reference: EFO:0003526
database_cross_reference: EMAPA:32685
database_cross_reference: TAO:0000360
database_cross_reference: XAO:0000337
database_cross_reference: ZFA:0000360
has exact synonym: embryonic heart tube
has exact synonym: endocardial heart tube
has exact synonym: endocardial tube
has_obo_namespace: uberon
id: UBERON:0004141
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

cardiac chamber
type: Class
subclass of: organ part
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: heart
definition: A cardiac chamber surrounds an enclosed cavity within the heart
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/276456008
database_cross_reference: FMA:7095
database_cross_reference: OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw
has exact synonym: chamber of heart
has exact synonym: heart chamber
has_obo_namespace: uberon
id: UBERON:0004151
comment: generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus

skeleton
type: Class
equivalent class: Class
  intersection of: anatomical collection
  intersection of: Restriction
    on property: has member
    some values from: skeletal element
subclass of: anatomical collection
subclass of: Restriction
  on property: part of
  some values from: skeletal system
subclass of: Restriction
  on property: has member
  some values from: skeletal element
definition: Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO]
has_relational_adjective: skeletal
database_cross_reference: Skeleton
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361378004
database_cross_reference: AEO:0000168
database_cross_reference: EHDAA2:0001843
database_cross_reference: EHDAA:5047
database_cross_reference: EMAPA:17213
database_cross_reference: FMA:23875
database_cross_reference: GAID:177
database_cross_reference: MA:0003006
database_cross_reference: MAT:0000032
database_cross_reference: MESH:D012863
database_cross_reference: MIAA:0000032
database_cross_reference: OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA
database_cross_reference: VSAO:0000026
database_cross_reference: XAO:0004053
database_cross_reference: galen:Skeleton
has exact synonym: set of all bones
has exact synonym: set of bones of body
has_obo_namespace: uberon
id: UBERON:0004288
in subset: uberon slim
in subset: efo slim
in subset: pheno slim

dermomyotome
type: Class
subclass of: multilaminar epithelium
subclass of: meso-epithelium
subclass of: transitional anatomical structure
subclass of: Restriction
  on property: develops_from
  some values from: somite
definition: The bilaminar epithelium formed from the myotome and dermatome.
imported from: oae.owl
imported from: uberon.owl
external_definition: Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768].
external_definition: Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO]
external_definition: Portion of somites that gives rise to dermis and muscles.[AAO]
external_definition: all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis.
homology_notes: Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG]
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1511786
database_cross_reference: C34140
database_cross_reference: AAO:0010572
database_cross_reference: AEO:0000214
database_cross_reference: EHDAA2:0003259
database_cross_reference: EMAPA:31109
database_cross_reference: FMA:295654
database_cross_reference: TAO:0001513
database_cross_reference: UMLS:C1511786
database_cross_reference: VHOG:0000676
database_cross_reference: ZFA:0001513
has_obo_namespace: uberon
has_related_synonym: dermamyotome
has_related_synonym: dermomyotomes
id: UBERON:0004290

heart rudiment
type: Class
subclass of: meso-epithelium
subclass of: Restriction
  on property: develops_from
  some values from: heart primordium
subclass of: Restriction
  on property: develops_from
  some values from: cardiogenic plate
definition: A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
imported from: oae.owl
imported from: uberon.owl
external_definition: The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO]
database_cross_reference: TAO:0000115
database_cross_reference: ZFA:0000115
has exact synonym: heart cone
has exact synonym: rudimentary heart
has_obo_namespace: uberon
id: UBERON:0004291

cardiovascular system
type: Class
equivalent class: Class
  intersection of: anatomical system
  intersection of: Restriction
    on property: part of
    some values from: circulatory system
  intersection of: Restriction
    on property: has part
    some values from: heart
  intersection of: Restriction
    on property: has part
    some values from: blood vessel
subclass of: anatomical system
subclass of: Restriction
  on property: part of
  some values from: circulatory system
subclass of: Restriction
  on property: has part
  some values from: heart
subclass of: Restriction
  on property: has part
  some values from: blood vessel
definition: Anatomical system that has as its parts the heart and blood vessels.
curator note: we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph.
imported from: oae.owl
imported from: uberon.owl
homology_notes: The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG]
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0007226
database_cross_reference: C12686
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278198007
database_cross_reference: AAO:0011001
database_cross_reference: BILA:0000016
database_cross_reference: BTO:0000088
database_cross_reference: CALOHA:TS-1297
database_cross_reference: EFO:0000791
database_cross_reference: EHDAA2:0000216
database_cross_reference: EHDAA:394
database_cross_reference: EMAPA:16104
database_cross_reference: EMAPA:16370
database_cross_reference: EV:0100017
database_cross_reference: FMA:7161
database_cross_reference: GAID:467
database_cross_reference: MA:0000010
database_cross_reference: MAT:0000016
database_cross_reference: MESH:D002319
database_cross_reference: MIAA:0000016
database_cross_reference: OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000010
database_cross_reference: UMLS:C0007226
database_cross_reference: VHOG:0000302
database_cross_reference: WikipediaCategory:Cardiovascular_system
database_cross_reference: XAO:0000100
database_cross_reference: XAO:0001010
database_cross_reference: ZFA:0000010
has_obo_namespace: uberon
has_related_synonym: CV system
has_related_synonym: Herz und Gefaesssystem
id: UBERON:0004535
in subset: uberon slim
in subset: vertebrate core
in subset: efo slim
in subset: pheno slim

blood vasculature
type: Class
equivalent class: Class
  intersection of: vasculature
  intersection of: Restriction
    on property: composed primarily of
    some values from: blood vessel
subclass of: vasculature
subclass of: Restriction
  on property: part of
  some values from: cardiovascular system
subclass of: Restriction
  on property: composed primarily of
  some values from: blood vessel
definition: A vascular network consisting of blood vessels.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: TAO:0001079
database_cross_reference: ZFA:0001079
has exact synonym: blood vascular network
has exact synonym: set of blood vessels
has_obo_namespace: uberon
has_related_synonym: blood system
has_related_synonym: blood vessel system
has_related_synonym: blood vessels
id: UBERON:0004537

conceptus
type: Class
subclass of: anatomical structure
subclass of: Restriction
  on property: has part
  some values from: embryonic structure
subclass of: Restriction
  on property: has part
  some values from: entire extraembryonic component
subclass of: Restriction
  on property: existence starts with
  some values from: embryo stage
subclass of: Restriction
  on property: existence ends with
  some values from: embryo stage
definition: The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP].
editor note: EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Conceptus
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1516779
database_cross_reference: C34131
database_cross_reference: AEO:0000194
database_cross_reference: BTO:0003834
database_cross_reference: EHDAA2:0000001
database_cross_reference: EHDAA2:0003235
database_cross_reference: EMAPA:36040
database_cross_reference: UMLS:C1516779
has exact synonym: embryo plus adnexa
has_obo_namespace: uberon
id: UBERON:0004716

gastrula
type: Class
equivalent class: Class
  intersection of: multicellular organism
  intersection of: Restriction
    on property: existence starts and ends during
    some values from: gastrula stage
subclass of: embryo
subclass of: Restriction
  on property: develops_from
  some values from: blastula
subclass of: Restriction
  on property: existence starts and ends during
  some values from: gastrula stage
definition: Organism at the gastrula stage.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: We explicitly merge the NCITA terms here
has_alternative_id: UBERON:0007012
database_cross_reference: Gastrula
database_cross_reference: Trilaminar blastocyst
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0017199
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1284022
database_cross_reference: C34057
database_cross_reference: C34058
database_cross_reference: BILA:0000060
database_cross_reference: BTO:0001403
database_cross_reference: FBbt:00005317
database_cross_reference: FMA:293108
database_cross_reference: GAID:1302
database_cross_reference: MESH:A16.254.412
database_cross_reference: MIAA:0000179
database_cross_reference: UMLS:C0017199
database_cross_reference: UMLS:C1284022
has exact synonym: gastrula embryo
has_obo_namespace: uberon
has_related_synonym: blastocystis trilaminaris
has_related_synonym: tri-laminar disc
has_related_synonym: tri-laminar disk
has_related_synonym: trilaminar blastocyst
has_related_synonym: trilaminar blastoderm
has_related_synonym: trilaminar disc
has_related_synonym: trilaminar disk
has_related_synonym: trilaminar germ
id: UBERON:0004734
in subset: pheno slim

skeletal tissue
type: Class
subclass of: connective tissue
subclass of: Restriction
  on property: part of
  some values from: skeletal element
definition: A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
imported from: oae.owl
imported from: uberon.owl
external_definition: A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/309311006
database_cross_reference: MA:0003047
database_cross_reference: VSAO:0000015
database_cross_reference: XAO:0004038
database_cross_reference: ZFA:0005619
has_obo_namespace: uberon
id: UBERON:0004755
comment: Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from

skeletal element
type: Class
subclass of: organ
subclass of: Restriction
  on property: part of
  some values from: skeletal system
definition: Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
imported from: oae.owl
imported from: uberon.owl
external_definition: Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
external_definition: Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
database_cross_reference: AAO:0011129
database_cross_reference: TAO:0001890
database_cross_reference: VSAO:0000128
database_cross_reference: XAO:0004012
database_cross_reference: ZFA:0005494
database_cross_reference: galen:SkeletalStructure
has_obo_namespace: uberon
id: UBERON:0004765
in subset: organ slim
in subset: uberon slim

articular system
type: Class
equivalent class: Class
  intersection of: anatomical collection
  intersection of: Restriction
    on property: has member
    some values from: skeletal joint
subclass of: anatomical collection
subclass of: Restriction
  on property: part of
  some values from: skeletal system
subclass of: Restriction
  on property: has member
  some values from: skeletal joint
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
definition: Anatomical system that consists of all the joints of the body.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361827000
database_cross_reference: EMAPA:35150
database_cross_reference: FMA:23878
database_cross_reference: MA:0003007
database_cross_reference: VSAO:0000181
has exact synonym: joint system
has exact synonym: set of all joints of body
has_obo_namespace: uberon
has_related_synonym: set of all joints
has_related_synonym: set of joints of body
id: UBERON:0004770

splanchnic layer of lateral plate mesoderm
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: part of
  some values from: lateral plate mesoderm
definition: Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP].
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors
has_broad_synonym: visceral mesoderm
database_cross_reference: Division into layers
database_cross_reference: AAO:0011102
database_cross_reference: BILA:0000044
database_cross_reference: FMA:295568
database_cross_reference: XAO:0000276
has exact synonym: inner layer of lateral plate mesoderm
has_obo_namespace: uberon
has_related_synonym: splanchnic mesoderm
id: UBERON:0004872
in subset: pheno slim

chordamesoderm
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: part of
  some values from: axial mesoderm
definition: The central region of trunk mesoderm. This tissue forms the notochord
imported from: oae.owl
imported from: uberon.owl
external_definition: Notochord rudiment[ZFIN:ZDB-PUB-961014-576].
external_ontology_notes: WP treats this as synonym of axial mesoderm. Induces neural tube. Gilbert: contains an anterior head process and the notochord.
database_cross_reference: AAO:0000478
database_cross_reference: EFO:0003426
database_cross_reference: TAO:0000091
database_cross_reference: ZFA:0000091
has exact synonym: axial chorda mesoderm
has exact synonym: chorda mesoderm
has exact synonym: dorsal mesoderm
has exact synonym: presumptive notochord
has_obo_namespace: uberon
id: UBERON:0004880
in subset: efo slim
in subset: pheno slim

articulation
type: Class
subclass of: multi organ part structure
subclass of: Restriction
  on property: part of
  some values from: articular system
definition: Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FBbt:00005811
has_narrow_synonym: joint
has_obo_namespace: uberon
id: UBERON:0004905
in subset: grouping class

subdivision of digestive tract
type: Class
equivalent class: Class
  intersection of: subdivision of tube
  intersection of: Restriction
    on property: subdivision of
    some values from: digestive tract
subclass of: subdivision of tube
subclass of: Restriction
  on property: part of
  some values from: digestive tract
subclass of: Restriction
  on property: subdivision of
  some values from: digestive tract
definition: A proximal-distal subdivision of the digestive tract.
curator note: intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FBbt:00100315
database_cross_reference: FMA:71131
has_obo_namespace: uberon
has_related_synonym: alimentary system subdivision
has_related_synonym: intestinal tract
has_related_synonym: segment of intestinal tract
has_related_synonym: subdivision of alimentary system
id: UBERON:0004921
in subset: non informative

organ component layer
type: Class
subclass of: organ part
subclass of: Restriction
  on property: part of
  some values from: anatomical wall
definition: A part of a wall of an organ that forms a layer.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:82485
has_obo_namespace: uberon
id: UBERON:0004923
in subset: upper level

neural groove
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: neural plate
definition: The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds.
imported from: oae.owl
imported from: uberon.owl
external_definition: The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and h…
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Neural groove
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0814992
database_cross_reference: C34224
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361463007
database_cross_reference: AAO:0011071
database_cross_reference: EMAPA:35594
database_cross_reference: FMA:295624
database_cross_reference: UMLS:C0814992
database_cross_reference: XAO:0000248
has_obo_namespace: uberon
id: UBERON:0005061

neural fold
type: Class
subclass of: epithelial fold
subclass of: embryonic tissue
subclass of: ecto-epithelium
subclass of: lateral structure
subclass of: Restriction
  on property: part of
  some values from: neural groove
subclass of: Restriction
  on property: in_lateral_side_of
  some values from: neural groove
definition: One of the two elevated edges of the neural groove[GO,MP].
imported from: oae.owl
imported from: uberon.owl
external_definition: In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold].
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Neural fold
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0814993
database_cross_reference: C34223
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361461009
database_cross_reference: EHDAA2:0001249
database_cross_reference: EMAPA:16142
database_cross_reference: EMAPA:16146
database_cross_reference: EMAPA:16151
database_cross_reference: EMAPA:16155
database_cross_reference: EMAPA:16159
database_cross_reference: EMAPA:16162
database_cross_reference: EMAPA:16288
database_cross_reference: EMAPA:16292
database_cross_reference: EMAPA:16295
database_cross_reference: EMAPA:16299
database_cross_reference: EMAPA:16303
database_cross_reference: EMAPA:16307
database_cross_reference: EMAPA:16528
database_cross_reference: FMA:295618
database_cross_reference: UMLS:C0814993
database_cross_reference: XAO:0004087
has exact synonym: medullary fold
has_obo_namespace: uberon
id: UBERON:0005062
in subset: pheno slim

neural rod
type: Class
subclass of: future central nervous system
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: neural keel
definition: A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN].
imported from: oae.owl
imported from: uberon.owl
external_definition: An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO]
database_cross_reference: EFO:0003498
database_cross_reference: TAO:0000133
database_cross_reference: ZFA:0000133
has_obo_namespace: uberon
has_related_synonym: neural tube rod
id: UBERON:0005068
in subset: efo slim

muscle structure
type: Class
subclass of: anatomical structure
definition: Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].
curator note: in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EMAPA:32715
database_cross_reference: FBbt:00005073
database_cross_reference: FMA:30316
has exact synonym: musculus
has_obo_namespace: uberon
has_related_synonym: muscle
has_related_synonym: muscle element
id: UBERON:0005090

epithelial fold
type: Class
subclass of: epithelium
definition: An epithelial sheet bent on a linear axis.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0005157

trunk region element
type: Class
equivalent class: Class
  intersection of: organ
  intersection of: Restriction
    on property: part of
    some values from: trunk
subclass of: organ
subclass of: Restriction
  on property: part of
  some values from: trunk
definition: An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: MA:0000516
has exact synonym: trunk organ
has_obo_namespace: uberon
id: UBERON:0005177
in subset: non informative
in subset: organ slim

thoracic cavity element
type: Class
equivalent class: Class
  intersection of: organ
  intersection of: Restriction
    on property: located_in
    some values from: thoracic cavity
subclass of: thoracic segment organ
subclass of: Restriction
  on property: part of
  some values from: thoracic segment of trunk
subclass of: Restriction
  on property: located_in
  some values from: thoracic cavity
definition: An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: MA:0000557
has exact synonym: thoracic cavity organ
has_obo_namespace: uberon
id: UBERON:0005178
in subset: non informative
in subset: pheno slim

thoracic segment organ
type: Class
equivalent class: Class
  intersection of: organ
  intersection of: Restriction
    on property: part of
    some values from: thoracic segment of trunk
subclass of: trunk region element
subclass of: Restriction
  on property: part of
  some values from: thoracic segment of trunk
definition: An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: MA:0000563
has_obo_namespace: uberon
has_related_synonym: upper body organ
id: UBERON:0005181
in subset: non informative

trunk mesenchyme
type: Class
equivalent class: Class
  intersection of: mesenchyme
  intersection of: Restriction
    on property: part of
    some values from: embryo
  intersection of: Restriction
    on property: part of
    some values from: trunk
subclass of: mesenchyme
subclass of: embryonic tissue
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: part of
  some values from: trunk
subclass of: Restriction
  on property: part of
  some values from: entire embryonic mesenchyme
definition: Mesenchyme that is part of a developing trunk.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EFO:0003485
database_cross_reference: EHDAA2:0002092
database_cross_reference: EHDAA:377
database_cross_reference: EMAPA:16177
database_cross_reference: TAO:0000081
database_cross_reference: VHOG:0000281
database_cross_reference: ZFA:0000081
has_obo_namespace: uberon
has_related_synonym: trunk and cervical mesenchyme
id: UBERON:0005256
in subset: vertebrate core
in subset: efo slim

embryonic tissue
type: Class
equivalent class: Class
  intersection of: tissue
  intersection of: Restriction
    on property: part of
    some values from: embryo
subclass of: tissue
subclass of: embryonic structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: part of
  some values from: embryonic structure
definition: A portion of tissue that is part of an embryo.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: CALOHA:TS-2100
has exact synonym: portion of embryonic tissue
has_obo_namespace: uberon
has_related_synonym: developing tissue
id: UBERON:0005291
in subset: upper level
in subset: pheno slim

developing anatomical structure
type: Class
subclass of: material anatomical entity
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO:0000125
database_cross_reference: CALOHA:TS-2122
database_cross_reference: EHDAA2:0003125
database_cross_reference: FBbt:00007006
database_cross_reference: FMA:292313
database_cross_reference: MIAA:0000019
has_obo_namespace: uberon
has_related_synonym: developing structure
has_related_synonym: developmental structure
has_related_synonym: developmental tissue
id: UBERON:0005423

primitive heart tube
type: Class
subclass of: multi-tissue structure
subclass of: embryonic structure
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: heart rudiment
definition: Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Primitive heart tube
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361522004
database_cross_reference: EHDAA2:0001512
database_cross_reference: EHDAA:424
database_cross_reference: EHDAA:436
database_cross_reference: EMAPA:16208
database_cross_reference: EMAPA:16215
database_cross_reference: FMA:321916
database_cross_reference: TAO:0000149
database_cross_reference: ZFA:0000149
has exact synonym: primitive heart tube
has_narrow_synonym: early primitive heart tube
has_obo_namespace: uberon
id: UBERON:0005498
in subset: vertebrate core

acellular membrane
type: Class
equivalent class: Class
  intersection of: acellular anatomical structure
  intersection of: Restriction
    on property: bounding layer of
    some values from: anatomical structure
subclass of: acellular anatomical structure
subclass of: Restriction
  on property: bounding layer of
  some values from: anatomical structure
definition: A acellular anatomical structure that is the bounding layer of a anatomical structure.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:63871
has_obo_namespace: uberon
id: UBERON:0005764

basement membrane of epithelium
type: Class
subclass of: acellular membrane
subclass of: Restriction
  on property: part of
  some values from: epithelium
definition: An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina.
curator note: this class represents a continuous sheet of basement membrane which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal membrane' represents a portion of substance on the scale of a single cell.
imported from: oae.owl
imported from: uberon.owl
present_in_taxon: NCBITaxon_80999
database_cross_reference: Basement membrane
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0004799
database_cross_reference: C13191
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/68989006
database_cross_reference: AAO:0010596
database_cross_reference: FMA:63872
database_cross_reference: GAID:915
database_cross_reference: UMLS:C0004799
has exact synonym: basement membrane of connective tissue
has exact synonym: membrana basalis
has_obo_namespace: uberon
has_related_synonym: basement membrane
id: UBERON:0005769

developing mesenchymal condensation
type: Class
subclass of: dense mesenchyme tissue
subclass of: cell condensation
definition: A delimited region of dense mesenchyme within looser mesenchyme.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO:0000148
database_cross_reference: EHDAA2_RETIRED:0003148
database_cross_reference: EHDAA:8979
has exact synonym: mesenchyme condensation
has_obo_namespace: uberon
id: UBERON:0005856

serous sac
type: Class
subclass of: organ
subclass of: Restriction
  on property: has part
  some values from: serous membrane
subclass of: Restriction
  on property: has part
  some values from: anatomical cavity
definition: Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]
imported from: oae.owl
imported from: uberon.owl
Contributor: cmungall
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362890006
database_cross_reference: EMAPA:16060
database_cross_reference: FMA:9689
database_cross_reference: MA:0000005
has_obo_namespace: uberon
id: UBERON:0005906
comment: See notes for serous membrane

axial skeleton plus cranial skeleton
type: Class
subclass of: mesoderm-derived structure
subclass of: subdivision of skeleton
subclass of: Restriction
  on property: part of
  some values from: skeleton
subclass of: Restriction
  on property: part of
  some values from: axial skeletal system
subclass of: Restriction
  on property: develops_from
  some values from: sclerotome
subclass of: Restriction
  on property: contributes to morphology of
  some values from: skeletal system
definition: Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified].
imported from: oae.owl
imported from: uberon.owl
external_definition: Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]
Contributor: cmungall
database_cross_reference: Axial skeleton
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0222645
database_cross_reference: C32172
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361725000
database_cross_reference: AAO:0000963
database_cross_reference: EMAPA:17214
database_cross_reference: EMAPA:18043
database_cross_reference: MA:0000308
database_cross_reference: UMLS:C0222645
database_cross_reference: VSAO:0000056
database_cross_reference: XAO:0004011
has_obo_namespace: uberon
has_related_synonym: skeleton axiale
id: UBERON:0005944
in subset: pheno slim
in subset: uberon slim

notochordal plate
type: Class
subclass of: unilaminar epithelium
subclass of: embryonic tissue
subclass of: ecto-epithelium
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: notochordal process
definition: The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
editor note: TODO - check ordering; awaiting confirmation from JB
imported from: oae.owl
imported from: uberon.owl
external_definition: The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1518429
database_cross_reference: C34231
database_cross_reference: EHDAA2:0001278
database_cross_reference: EHDAA:264
database_cross_reference: EMAPA:16101
database_cross_reference: UMLS:C1518429
database_cross_reference: VHOG:0001212
has_obo_namespace: uberon
id: UBERON:0006267
in subset: emapa ehdaa2

notochordal process
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: develops_from
  some values from: ectoderm
definition: A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1518430
database_cross_reference: C34232
database_cross_reference: EHDAA2:0001279
database_cross_reference: EHDAA:224
database_cross_reference: EMAPA:16102
database_cross_reference: FMA:293135
database_cross_reference: UMLS:C1518430
database_cross_reference: VHOG:0001213
has_obo_namespace: uberon
has_related_synonym: chordamesoderm
has_related_synonym: presumptive notochord
id: UBERON:0006268
in subset: emapa ehdaa2
comment: The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.

bodily fluid
type: Class
subclass of: organism substance
editor preferred label: bodily fluid
definition: Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
imported from: oae.owl
imported from: Ontology for Biomedical Investigations
imported from: uberon.owl
has_broad_synonym: fluid
database_cross_reference: Body fluid
database_cross_reference: birnlex 20
database_cross_reference: FMA:280556
database_cross_reference: GAID:266
database_cross_reference: MESH:D001826
database_cross_reference: galen:BodyFluid
has exact synonym: body fluid
has_obo_namespace: uberon
id: UBERON:0006314
in subset: pheno slim

pharynx
type: Class
subclass of: subdivision of digestive tract
definition: The pharynx is the part of the digestive system immediately posterior to the mouth[GO].
curator note: currently this is an extremely generic class, encompassing both protostomes and deuterostomes.
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: branchial
has_relational_adjective: pharyngeal
database_cross_reference: FBbt:00005380
database_cross_reference: MAT:0000049
database_cross_reference: MIAA:0000049
has_obo_namespace: uberon
has_related_synonym: anterior part of foregut
has_related_synonym: pharyngeal tube
id: UBERON:0006562
in subset: grouping class
in subset: uberon slim

presumptive endoderm
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: part of
    some values from: blastula
  intersection of: Restriction
    on property: has potential to develop into
    some values from: endoderm
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: blastula
subclass of: Restriction
  on property: has potential to develop into
  some values from: endoderm
definition: Presumptive structure of the blastula that will develop into endoderm.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0000471
database_cross_reference: EFO:0003437
database_cross_reference: TAO:0000416
database_cross_reference: ZFA:0000416
has_obo_namespace: uberon
id: UBERON:0006595
in subset: efo slim

presumptive blood
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: blood
subclass of: presumptive structure
subclass of: Restriction
  on property: has potential to develop into
  some values from: blood
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0000468
database_cross_reference: EFO:0003439
database_cross_reference: TAO:0000568
database_cross_reference: ZFA:0000568
has exact synonym: future blood
has_obo_namespace: uberon
id: UBERON:0006596
in subset: efo slim

presumptive structure
type: Class
equivalent class: Class
  intersection of: developing anatomical structure
  intersection of: Restriction
    on property: part of
    some values from: embryo
  intersection of: Restriction
    on property: has potential to develop into
    some values from: anatomical structure
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: has potential to develop into
  some values from: anatomical structure
definition: Portion of embryonic tissue determined by fate mapping to become a structure.
editor note: Consider merging with anlage
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0000479
database_cross_reference: TAO:0001116
database_cross_reference: ZFA:0001116
has exact synonym: future structure
has exact synonym: presumptive structures
has_obo_namespace: uberon
id: UBERON:0006598

presumptive ectoderm
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: part of
    some values from: blastula
  intersection of: Restriction
    on property: has potential to develop into
    some values from: ectoderm
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: blastula
subclass of: Restriction
  on property: has potential to develop into
  some values from: ectoderm
definition: Presumptive structure of the blastula that will develop into ectoderm.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0000470
database_cross_reference: EFO:0003466
database_cross_reference: TAO:0001376
database_cross_reference: XAO:0004132
database_cross_reference: ZFA:0001376
has_obo_namespace: uberon
has_related_synonym: presumptive epidermis
id: UBERON:0006601
in subset: efo slim

presumptive mesoderm
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: part of
    some values from: blastula
  intersection of: Restriction
    on property: has potential to develop into
    some values from: mesoderm
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: blastula
subclass of: Restriction
  on property: has potential to develop into
  some values from: mesoderm
definition: Presumptive structure of the blastula that will develop into mesoderm.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AAO:0000476
database_cross_reference: EFO:0003467
database_cross_reference: TAO:0001377
database_cross_reference: ZFA:0001377
has_obo_namespace: uberon
id: UBERON:0006603
in subset: efo slim

squamous epithelium
type: Class
subclass of: epithelium
definition: An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium
database_cross_reference: Squamous epithelium
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0221909
database_cross_reference: C12848
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/40118003
database_cross_reference: BTO:0002072
database_cross_reference: UMLS:C0221909
has_obo_namespace: uberon
id: UBERON:0006914

vascular cord
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: primordial vasculature
definition: The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA].
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EFO:0003709
database_cross_reference: TAO:0005077
database_cross_reference: ZFA:0005077
has_obo_namespace: uberon
id: UBERON:0006965
in subset: efo slim

anatomical surface
type: Class
subclass of: immaterial anatomical entity
definition: A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1515977
database_cross_reference: C34022
database_cross_reference: AAO:0010270
database_cross_reference: BILA:0000010
database_cross_reference: CARO:0001002
database_cross_reference: EHDAA2:0003192
database_cross_reference: FMA:24137
database_cross_reference: ID:0000000
database_cross_reference: UMLS:C1515977
database_cross_reference: ZFA:0005594
has_obo_namespace: uberon
id: UBERON:0006984
in subset: upper level
comment: Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism.

cardiac mesoderm
type: Class
subclass of: mesoderm-derived structure
subclass of: embryonic tissue
subclass of: Restriction
  on property: part of
  some values from: primary heart field
subclass of: Restriction
  on property: part of
  some values from: anterior lateral plate mesoderm
subclass of: Restriction
  on property: develops_from
  some values from: splanchnic layer of lateral plate mesoderm
subclass of: Restriction
  on property: developmentally_induced_by
  some values from: anterior lateral plate mesoderm
definition: The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO].
editor note: consider FBbt:00005541 ! cardiogenic mesoderm
editor note: review EHDAA2 placement
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/360387000
database_cross_reference: AAO:0011021
database_cross_reference: BILA:0000051
database_cross_reference: EFO:0000315
database_cross_reference: EHDAA2:0000214
database_cross_reference: EHDAA:385
database_cross_reference: FMA:293143
database_cross_reference: VHOG:0001641
database_cross_reference: XAO:0000235
has_obo_namespace: uberon
has_related_synonym: cardiogenic mesoderm
has_related_synonym: cardiogenic region
has_related_synonym: heart primordia
id: UBERON:0007005
in subset: efo slim
in subset: pheno slim

cleaving embryo
type: Class
equivalent class: Class
  intersection of: multicellular organism
  intersection of: Restriction
    on property: existence starts with
    some values from: cleavage stage
  intersection of: Restriction
    on property: existence ends with
    some values from: cleavage stage
subclass of: embryo
subclass of: Restriction
  on property: existence starts with
  some values from: cleavage stage
subclass of: Restriction
  on property: existence ends with
  some values from: cleavage stage
definition: Organism at the cleavage stage.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BILA:0000058
has_obo_namespace: uberon
id: UBERON:0007010

presumptive gut
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: digestive tract
subclass of: presumptive structure
subclass of: Restriction
  on property: has developmental contribution from
  some values from: endoderm
subclass of: Restriction
  on property: has developmental contribution from
  some values from: mesoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: digestive tract
subclass of: Restriction
  on property: existence starts during
  some values from: gastrula stage
imported from: oae.owl
imported from: uberon.owl
development_notes: The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1514442
database_cross_reference: C34268
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/360394002
database_cross_reference: BILA:0000084
database_cross_reference: UMLS:C1514442
has exact synonym: future digestive tract
has exact synonym: future digestive tube
has exact synonym: future gut
has exact synonym: primitive gut
has_obo_namespace: uberon
has_related_synonym: embryonic digestive tube
has_related_synonym: primordial digestive tube
has_related_synonym: primordial gut
id: UBERON:0007026

primary circulatory organ
type: Class
subclass of: circulatory organ
definition: A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
imported from: oae.owl
imported from: uberon.owl
taxon_notes: note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
present in taxon: NCBITaxon 7718
database_cross_reference: FBbt:00003154
database_cross_reference: SPD:0000130
database_cross_reference: TADS:0000147
has_narrow_synonym: dorsal tube
has_narrow_synonym: heart
has_obo_namespace: uberon
has_related_synonym: adult heart
id: UBERON:0007100
in subset: grouping class
comment: Gene notes: Bmp, Nkx, Gata

neural keel
type: Class
subclass of: future central nervous system
subclass of: Restriction
  on property: develops_from
  some values from: neural plate
definition: An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section.
imported from: oae.owl
imported from: uberon.owl
external_definition: An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO]
database_cross_reference: EFO:0003497
database_cross_reference: TAO:0000131
database_cross_reference: ZFA:0000131
has_obo_namespace: uberon
has_related_synonym: presumptive central nervous system
id: UBERON:0007135
in subset: efo slim

neonate stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: sexually immature stage
definition: Of or pertaining to the period of time immediately following birth, or to the newborn.
editor note: consider splitting infant/newborn
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Infant
database_cross_reference: Category:Infant organism
database_cross_reference: Category:Newborn organism
database_cross_reference: BTO:0001762
database_cross_reference: EV:0300037
database_cross_reference: HsapDv:0000082
database_cross_reference: MmusDv:0000096
database_cross_reference: NIF_Organism:birnlex_695
database_cross_reference: OGES:000025
has exact synonym: neonatal stage
has_narrow_synonym: fledgling stage
has_narrow_synonym: hatchling
has_narrow_synonym: hatchling stage
has_narrow_synonym: infant stage
has_narrow_synonym: nestling stage
has_narrow_synonym: pouch stage
has_narrow_synonym: puggle
has_narrow_synonym: puggle stage
has_obo_namespace: uberon
has_related_synonym: newborn stage
id: UBERON:0007221

presumptive segmental plate
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: presomitic mesoderm
subclass of: presumptive structure
subclass of: Restriction
  on property: develops_from
  some values from: trunk paraxial mesoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: presomitic mesoderm
definition: A presumptive structure that has the potential to develop into a presomitic mesoderm.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EFO:0003421
database_cross_reference: TAO:0000053
database_cross_reference: ZFA:0000053
has_obo_namespace: uberon
has_related_synonym: presumptive segmental plates
id: UBERON:0007282
in subset: efo slim

presumptive neural plate
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: neural plate
subclass of: future central nervous system
subclass of: Restriction
  on property: part of
  some values from: gastrula
subclass of: Restriction
  on property: develops_from
  some values from: neurectoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: neural plate
definition: A presumptive structure that has the potential to develop into a neural plate.
editor note: consider merging
imported from: oae.owl
imported from: uberon.owl
external_definition: Region of the gastrula which gives rise to the neural plate.[TAO]
database_cross_reference: EFO:0003424
database_cross_reference: TAO:0000063
database_cross_reference: ZFA:0000063
has exact synonym: prospective neuroectoderm
has exact synonym: prospective vegetal ectoderm
has_obo_namespace: uberon
id: UBERON:0007284
in subset: efo slim

presumptive paraxial mesoderm
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: paraxial mesoderm
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: mesoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: paraxial mesoderm
definition: A presumptive structure that has the potential to develop into a paraxial mesoderm.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EFO:0003443
database_cross_reference: TAO:0000591
database_cross_reference: XAO:0004134
database_cross_reference: ZFA:0000591
has exact synonym: future paraxial mesoderm
has_obo_namespace: uberon
id: UBERON:0007285
in subset: efo slim

outer epithelium
type: Class
equivalent class: Class
  intersection of: epithelium
  intersection of: Restriction
    on property: bounding layer of
    some values from: multicellular organism
  intersection of: Restriction
    on property: develops_from
    some values from: enveloping layer of ectoderm
subclass of: surface structure
subclass of: ecto-epithelium
subclass of: Restriction
  on property: bounding layer of
  some values from: multicellular organism
subclass of: Restriction
  on property: develops_from
  some values from: enveloping layer of ectoderm
definition: The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].
editor note: this grouping class exists primarily to align with GO - see GO:0008544.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Epidermis (zoology)
database_cross_reference: BSA:0000073
database_cross_reference: BTO:0000313
database_cross_reference: FBbt:00004993
database_cross_reference: HAO:0000298
database_cross_reference: TADS:0000109
database_cross_reference: WBbt:0005733
has exact synonym: epidermis
has exact synonym: epidermis (sensu Metazoa)
has exact synonym: outer epidermal layer
has exact synonym: outer epithelial layer
has_obo_namespace: uberon
has_related_synonym: hypoderm
has_related_synonym: hypodermis
id: UBERON:0007376
in subset: grouping class

stratum compactum
type: Class
subclass of: mesoderm-derived structure
subclass of: ectoderm-derived structure
subclass of: integumentary system layer
subclass of: Restriction
  on property: part of
  some values from: dermis
definition: Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network.
imported from: oae.owl
imported from: uberon.owl
external_definition: Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. Le Guellec et al, 2004.[TAO]
axiom_lost_from_external_ontology: relationship loss: develops_from collagenous dermal stroma (TAO:0001186)[TAO]
structure_notes: connective tissue in the skin is usually diffuse and irregular, although in some species collagen bundles are arranged in a distinct ordered layer in the dermis
database_cross_reference: AAO:0010600
database_cross_reference: TAO:0001182
database_cross_reference: ZFA:0001182
has exact synonym: dermal deep region
has_obo_namespace: uberon
id: UBERON:0007377

enveloping layer of ectoderm
type: Class
subclass of: unilaminar epithelium
subclass of: embryonic tissue
subclass of: ecto-epithelium
subclass of: Restriction
  on property: bounding layer of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: external ectoderm
definition: Outermost layer of cells surrounding the embryo.
imported from: oae.owl
imported from: uberon.owl
external_definition: Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO]
axiom_lost_from_external_ontology: relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO]
taxon_notes: Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm.
database_cross_reference: EFO:0003425
database_cross_reference: TAO:0000086
database_cross_reference: ZFA:0000086
has exact synonym: EVL
has exact synonym: enveloping layer
has_obo_namespace: uberon
id: UBERON:0007383
in subset: efo slim

epithelial tube open at both ends
type: Class
subclass of: epithelial tube
definition: An epithelial tube open at both ends that allows fluid flow.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO_RETIRED:0000116
database_cross_reference: RETIRED_EHDAA2:0003116
has_obo_namespace: uberon
id: UBERON:0007500

epithelial vesicle
type: Class
subclass of: epithelium
definition: A closed epithelium with a lumen.
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: EHDAA2:0003119
database_cross_reference: AEO:0000119
database_cross_reference: EHDAA2:0003119
has_obo_namespace: uberon
id: UBERON:0007503

dense mesenchyme tissue
type: Class
subclass of: mesenchyme
definition: Mesenchyme with little extracellular matrix.
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: EHDAA2:0003146
database_cross_reference: AEO:0000146
database_cross_reference: EHDAA2:0003146
has_obo_namespace: uberon
id: UBERON:0007524

migrating mesenchyme population
type: Class
subclass of: mesenchyme
definition: Mesenchymal cells that are migrating.
editor note: this class will be an important part of the NC reorganization
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: EHDAA2:0003152
database_cross_reference: AEO:0000152
database_cross_reference: EHDAA2:0003152
has_obo_namespace: uberon
id: UBERON:0007530

layer of synovial tissue
type: Class
equivalent class: Class
  intersection of: serous membrane
  intersection of: Restriction
    on property: produces
    some values from: synovial fluid
subclass of: serous membrane
subclass of: Restriction
  on property: composed primarily of
  some values from: connective tissue
subclass of: Restriction
  on property: produces
  some values from: synovial fluid
definition: A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO].
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BTO:0001338
database_cross_reference: CALOHA:TS-0998
database_cross_reference: FMA:66762
has exact synonym: synovium
has_narrow_synonym: stratum synoviale
has_narrow_synonym: synovial layer
has_narrow_synonym: synovial membrane
has_obo_namespace: uberon
has_related_synonym: synovial tissue
id: UBERON:0007616

synovial cavity of joint
type: Class
equivalent class: Class
  intersection of: anatomical cavity
  intersection of: Restriction
    on property: luminal space of
    some values from: synovial joint
subclass of: anatomical cavity
subclass of: Restriction
  on property: luminal space of
  some values from: synovial joint
definition: An anatomical cavity that surrounded_by a synovial joint.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:11356
has exact synonym: articular cavity (synovial joint)
has exact synonym: cavitas articularis (junctura synovialis)
has exact synonym: cavity of synovial joint
has_obo_namespace: uberon
has_related_synonym: joint cavity
has_related_synonym: synovial cavity
id: UBERON:0007617

anlage
type: Class
subclass of: tissue
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part of
  some values from: multicellular organism
definition: Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue.
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: field
database_cross_reference: Anlage (biology)
database_cross_reference: AEO:0000170
database_cross_reference: EFO:0001649
database_cross_reference: EHDAA2:0003170
database_cross_reference: FBbt:00005426
has exact synonym: developmental field
has_obo_namespace: uberon
has_related_synonym: future organ
has_related_synonym: organ field
id: UBERON:0007688
in subset: efo slim

serous fluid
type: Class
equivalent class: Class
  intersection of: bodily fluid
  intersection of: Restriction
    on property: located_in
    some values from: serous sac
  intersection of: Restriction
    on property: produced_by
    some values from: serous gland
subclass of: bodily secretion
subclass of: bodily fluid
subclass of: Restriction
  on property: located_in
  some values from: serous sac
subclass of: Restriction
  on property: produced_by
  some values from: serous gland
definition: Any fluid produced by a serous gland.
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: the FMA def is Transudate contained in a serous sac
database_cross_reference: Serous fluid
database_cross_reference: FMA:20932
has exact synonym: serous gland fluid
has_obo_namespace: uberon
id: UBERON:0007794

vascular system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: part of
  some values from: cardiovascular system
definition: Anatomical system that consists of all blood and lymph vessels.
editor note: consider merging with vasculature
imported from: oae.owl
imported from: uberon.owl
external_definition: The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
external_ontology_notes: in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0489903
database_cross_reference: C33854
database_cross_reference: BTO:0001085
database_cross_reference: CALOHA:TS-2053
database_cross_reference: EHDAA2:0004520
database_cross_reference: EMAPA:35905
database_cross_reference: MA:0002718
database_cross_reference: UMLS:C0489903
has_obo_namespace: uberon
has_related_synonym: Gefaesssystem@ge
id: UBERON:0007798
in subset: pheno slim

craniocervical region
type: Class
subclass of: organism subdivision
subclass of: Restriction
  on property: part of
  some values from: anterior region of body
subclass of: Restriction
  on property: part of
  some values from: body proper
subclass of: Restriction
  on property: has part
  some values from: head
subclass of: Restriction
  on property: has part
  some values from: pharynx
definition: The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0460004
database_cross_reference: C12418
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361355005
database_cross_reference: CALOHA:TS-2356
database_cross_reference: EV:0100009
database_cross_reference: FMA:280881
database_cross_reference: MA:0000006
database_cross_reference: UMLS:C0460004
database_cross_reference: WikipediaCategory:Head_and_neck
database_cross_reference: galen:HeadAndNeck
has_obo_namespace: uberon
has_related_synonym: cephalic area
has_related_synonym: cephalic part of animal
has_related_synonym: cephalic region
has_related_synonym: head and neck
has_related_synonym: head or neck
id: UBERON:0007811
in subset: pheno slim

entire embryonic mesenchyme
type: Class
subclass of: anatomical cluster
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: has developmental contribution from
  some values from: mesoderm
subclass of: Restriction
  on property: composed primarily of
  some values from: mesenchyme
definition: Sum total of mesenchyme in the embryo.
editor note: consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm)
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: UBERON:0003313
database_cross_reference: EHDAA2:0001113
database_cross_reference: EHDAA:177
database_cross_reference: EMAPA:16097
has_obo_namespace: uberon
id: UBERON:0009142

subdivision of trunk
type: Class
subclass of: organism subdivision
subclass of: Restriction
  on property: part of
  some values from: trunk
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/22943007
database_cross_reference: FMA:25054
has exact synonym: region of trunk
has exact synonym: trunk subdivision
has_obo_namespace: uberon
id: UBERON:0009569
in subset: non informative

trunk paraxial mesoderm
type: Class
subclass of: mesoderm-derived structure
subclass of: trunk mesenchyme
subclass of: Restriction
  on property: part of
  some values from: paraxial mesoderm
subclass of: Restriction
  on property: part of
  some values from: trunk mesenchyme
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EHDAA2:0002094
has exact synonym: trunk and cervical paraxial mesenchyme
has_obo_namespace: uberon
has_related_synonym: trunk paraxial mesenchyme
id: UBERON:0009618

glandular acinus
type: Class
subclass of: cell cluster
subclass of: Restriction
  on property: part of
  some values from: gland
definition: The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form.
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: acinar
has_broad_synonym: acinus
database_cross_reference: Acinus
database_cross_reference: FMA:55588
has_obo_namespace: uberon
has_related_synonym: acini
id: UBERON:0009842

anterior lateral plate mesoderm
type: Class
subclass of: mesoderm-derived structure
subclass of: embryonic tissue
subclass of: Restriction
  on property: part of
  some values from: lateral plate mesoderm
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EFO:0003704
database_cross_reference: TAO:0005041
database_cross_reference: ZFA:0005041
has exact synonym: ALPM
has_obo_namespace: uberon
id: UBERON:0009881
in subset: efo slim

multicellular anatomical structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that has more than one cell as a part.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: CARO:0010000
database_cross_reference: FBbt:00100313
has exact synonym: multicellular structure
has_obo_namespace: uberon
id: UBERON:0010000
in subset: upper level

future dermis
type: Class
equivalent class: Class
  intersection of: mesenchyme
  intersection of: Restriction
    on property: has potential to develop into
    some values from: dermis
subclass of: mesenchyme
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: part of
  some values from: integument
subclass of: Restriction
  on property: develops_from
  some values from: sclerotome
subclass of: Restriction
  on property: develops_from
  some values from: dermatome
subclass of: Restriction
  on property: has potential to develop into
  some values from: dermis
definition: Mesenchyme that has the potential to develop into a dermis.
editor note: check development
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EHDAA2:0000598
has_obo_namespace: uberon
id: UBERON:0010083

structure with developmental contribution from neural crest
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: has developmental contribution from
    some values from: neural crest
subclass of: anatomical structure
subclass of: Restriction
  on property: has developmental contribution from
  some values from: neural crest
definition: An anatomical structure that has some part that develops from the neural crest.
curator note: Grouping term for query purposes
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0010314
in subset: grouping class

germ layer / neural crest
type: Class
subclass of: embryonic tissue
subclass of: Restriction
  on property: develops_from
  some values from: epiblast (generic)
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0010316

ecto-epithelium
type: Class
equivalent class: Class
  intersection of: epithelium
  intersection of: Restriction
    on property: develops_from
    some values from: ectoderm
subclass of: epithelium
subclass of: ectoderm-derived structure
subclass of: Restriction
  on property: develops_from
  some values from: ectoderm
definition: Epithelium composed of cells that develops from the ectoderm[FMA,modified].
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:69064
has exact synonym: ectoderm-derived epithelium
has_obo_namespace: uberon
id: UBERON:0010371

subdivision of skeleton
type: Class
subclass of: organ system subdivision
subclass of: Restriction
  on property: part of
  some values from: subdivision of skeletal system
subclass of: Restriction
  on property: part of
  some values from: skeleton
definition: Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
imported from: oae.owl
imported from: uberon.owl
external_definition: Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/129140006
database_cross_reference: FMA:23879
database_cross_reference: VSAO:0000042
has exact synonym: skeletal subdivision
has_obo_namespace: uberon
has_related_synonym: subdivision of skeleton (in vivo)
id: UBERON:0010912
in subset: non informative

nonsynovial joint
type: Class
subclass of: skeletal joint
definition: Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:7491
has exact synonym: solid joint
has_obo_namespace: uberon
id: UBERON:0011134

axial skeletal system
type: Class
subclass of: subdivision of skeletal system
subclass of: Restriction
  on property: has part
  some values from: skeletal joint
subclass of: Restriction
  on property: has part
  some values from: axial skeleton plus cranial skeleton
definition: Subdivision of the skeletal system which consists of the axial skeleton plus associated joints.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:7483
has_obo_namespace: uberon
id: UBERON:0011137

post-cranial axial skeletal system
type: Class
subclass of: subdivision of skeletal system
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: develops_from
  some values from: sclerotome
definition: Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints.
imported from: oae.owl
imported from: uberon.owl
Contributor: cmungall
has_broad_synonym: axial skeletal system
database_cross_reference: FMA:302077
has_obo_namespace: uberon
id: UBERON:0011138

organ system subdivision
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: anatomical system
definition: A subdivision of an anatomical system.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91690000
database_cross_reference: FBbt:00007330
database_cross_reference: FMA:67509
has_obo_namespace: uberon
id: UBERON:0011216
in subset: upper level

embryonic skin basal layer
type: Class
subclass of: unilaminar epithelium
subclass of: ecto-epithelium
subclass of: Restriction
  on property: part of
  some values from: integument
subclass of: Restriction
  on property: develops_from
  some values from: external ectoderm
editor note: compare with 'stratum basale of epidermis'. This class is the source for many adult structures - see WP2062. See also: 'enveloping layer of ectoderm'
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EHDAA2:0001845
has_obo_namespace: uberon
has_related_synonym: basal cell layer of skin
has_related_synonym: outer epithelium of body
id: UBERON:0011272

cell condensation
type: Class
subclass of: anatomical structure
definition: Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995).
editor note: consider obsoleting, coordinate with VSAO
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: VSAO:0000006
database_cross_reference: XAO:0004021
has_obo_namespace: uberon
id: UBERON:0011585

subdivision of organism along main body axis
type: Class
subclass of: organism subdivision
subclass of: Restriction
  on property: part of
  some values from: main body axis
definition: A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.
editor note: Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem
imported from: oae.owl
imported from: uberon.owl
has exact synonym: axial subdivision of organism
has_obo_namespace: uberon
has_related_synonym: body segment
has_related_synonym: main body segment
id: UBERON:0011676
in subset: upper level

embryonic cardiovascular system
type: Class
equivalent class: Class
  intersection of: cardiovascular system
  intersection of: Restriction
    on property: part of
    some values from: conceptus
subclass of: cardiovascular system
subclass of: Restriction
  on property: part of
  some values from: conceptus
definition: A cardiovascular system that is part of a conceptus.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: C34148
database_cross_reference: EHDAA2:0000216
database_cross_reference: FMA:305965
has exact synonym: conceptus cardiovascular system
has_obo_namespace: uberon
has_related_synonym: embryonic circulatory system
has_related_synonym: fetal circulatory system
id: UBERON:0011695

irregular connective tissue
type: Class
subclass of: connective tissue
definition: Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:20107
has_obo_namespace: uberon
id: UBERON:0011821

dense irregular connective tissue
type: Class
equivalent class: Class
  intersection of: irregular connective tissue
  intersection of: Restriction
    on property: composed primarily of
    some values from: collection of collagen fibrils
subclass of: irregular connective tissue
subclass of: dense connective tissue
subclass of: Restriction
  on property: composed primarily of
  some values from: collection of collagen fibrils
definition: Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.
imported from: oae.owl
imported from: uberon.owl
external_definition: Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT]
database_cross_reference: Dense irregular connective tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0738366
database_cross_reference: C32882
database_cross_reference: FMA:20109
database_cross_reference: UMLS:C0738366
has exact synonym: irregular dense connective tissue
has exact synonym: typus irregularis (textus connectivus collagenosus compactus)
has_obo_namespace: uberon
id: UBERON:0011822

dense connective tissue
type: Class
equivalent class: Class
  intersection of: connective tissue
  intersection of: Restriction
    on property: composed primarily of
    some values from: collection of collagen fibrils
subclass of: connective tissue
subclass of: Restriction
  on property: composed primarily of
  some values from: collection of collagen fibrils
definition: Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets
editor note: our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid.
imported from: oae.owl
imported from: uberon.owl
external_definition: Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT]
database_cross_reference: Dense connective tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1511770
database_cross_reference: C32450
database_cross_reference: AAO:0000121
database_cross_reference: UMLS:C1511770
has_obo_namespace: uberon
id: UBERON:0011823

loose connective tissue
type: Class
subclass of: irregular connective tissue
definition: Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Loose connective tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1253917
database_cross_reference: C33007
database_cross_reference: FMA:19783
database_cross_reference: UMLS:C1253917
has exact synonym: textus connectivus collagenosus laxus
has exact synonym: textus connectivus laxus
has_obo_namespace: uberon
id: UBERON:0011825

acinus of exocrine gland
type: Class
equivalent class: Class
  intersection of: glandular acinus
  intersection of: Restriction
    on property: part of
    some values from: exocrine gland
subclass of: glandular acinus
subclass of: Restriction
  on property: part of
  some values from: exocrine gland
definition: An acinus that is part of a exocrine gland.
imported from: oae.owl
imported from: uberon.owl
has exact synonym: exocrine gland acinus
has_obo_namespace: uberon
id: UBERON:0011858

collection of collagen fibrils
type: Class
subclass of: acellular anatomical structure
imported from: oae.owl
imported from: uberon.owl
external_ontology_notes: the FMA class specifically refers to ureter
database_cross_reference: C32339
database_cross_reference: FMA:63212
database_cross_reference: MESH:D024022
database_cross_reference: NIF_Subcellular:sao7547390221
has_obo_namespace: uberon
id: UBERON:0011860

coelom
type: Class
subclass of: multi-tissue structure
definition: The aggregate of the coelemic cavity lumen plus the membranes that line the lumen.
editor note: EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining.
imported from: oae.owl
imported from: uberon.owl
has_relational_adjective: coelomic
database_cross_reference: Coelom
database_cross_reference: EHDAA2:0004731
has_narrow_synonym: enterocoelom
has_narrow_synonym: haemocoelom
has_narrow_synonym: schizocoelom
has_obo_namespace: uberon
has_related_synonym: coelem
has_related_synonym: coelomic cavity
id: UBERON:0011997

meso-epithelium
type: Class
equivalent class: Class
  intersection of: epithelium
  intersection of: Restriction
    on property: develops_from
    some values from: mesoderm
subclass of: epithelium
subclass of: mesoderm-derived structure
subclass of: Restriction
  on property: develops_from
  some values from: mesoderm
definition: Epithelium that derives from the mesoderm. [Automatically generated definition].
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:86452
has exact synonym: mesoderm-derived epithelium
has exact synonym: mesoepithelium
has_obo_namespace: uberon
id: UBERON:0012275

serous acinus
type: Class
equivalent class: Class
  intersection of: glandular acinus
  intersection of: Restriction
    on property: part of
    some values from: serous gland
subclass of: acinus of exocrine gland
subclass of: Restriction
  on property: part of
  some values from: serous gland
definition: The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:86279
has exact synonym: acinus of serous gland
has_obo_namespace: uberon
id: UBERON:0013232

space surrounding organism
type: Class
equivalent class: Class
  intersection of: anatomical space
  intersection of: Restriction
    on property: surrounds
    some values from: multicellular organism
subclass of: anatomical space
subclass of: Restriction
  on property: surrounds
  some values from: multicellular organism
definition: The space that surrounds an organism.
imported from: oae.owl
imported from: uberon.owl
has exact synonym: external to organism
has exact synonym: outside of body
has_obo_namespace: uberon
id: UBERON:0013514

subdivision of tube
type: Class
subclass of: organ part
subclass of: Restriction
  on property: part of
  some values from: tube
subclass of: Restriction
  on property: has part
  some values from: anatomical wall
subclass of: Restriction
  on property: has part
  some values from: anatomical space
subclass of: Restriction
  on property: subdivision of
  some values from: tube
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0013522

anatomical conduit space
type: Class
subclass of: anatomical space
subclass of: Class
  intersection of: Restriction
    on property: connects
    min qualified cardinality: 2
    on class: anatomical space
  intersection of: Restriction
    on property: connects
    max qualified cardinality: 2
    on class: anatomical space
subclass of: Restriction
  on property: luminal space of
  some values from: anatomical conduit
definition: An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified].
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:9338
has_narrow_synonym: foramen space
has_obo_namespace: uberon
id: UBERON:0013686

main body axis
type: Class
subclass of: organism subdivision
definition: A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0013701
in subset: non informative

body proper
type: Class
subclass of: organism subdivision
subclass of: Restriction
  on property: part of
  some values from: main body axis
definition: The region of the organism associated with the visceral organs.
imported from: oae.owl
imported from: uberon.owl
external_definition: Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424].
spatially disjoint from: UBERON_0002415
database_cross_reference: AEO:0000103
database_cross_reference: BTO:0001489
database_cross_reference: EMAPA:36031
database_cross_reference: FMA:231424
has_obo_namespace: uberon
has_related_synonym: body
has_related_synonym: whole body
id: UBERON:0013702
in subset: non informative

integumentary system layer
type: Class
equivalent class: Class
  intersection of: organ component layer
  intersection of: Restriction
    on property: part of
    some values from: integumental system
subclass of: organ component layer
subclass of: Restriction
  on property: part of
  some values from: integumental system
definition: A organ component layer that is part of a integumental system.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/314820002
has_narrow_synonym: layer of skin
has_narrow_synonym: skin layer
has_obo_namespace: uberon
id: UBERON:0013754
in subset: non informative

thoracic skeleton
type: Class
subclass of: mesoderm-derived structure
subclass of: subdivision of skeleton
subclass of: Restriction
  on property: part of
  some values from: thoracic segment of trunk
subclass of: Restriction
  on property: part of
  some values from: postcranial axial skeleton
definition: Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: Thoracic skeleton
database_cross_reference: EHDAA2:0002013
database_cross_reference: FMA:77169
has exact synonym: skeleton of thorax
has exact synonym: thoracic part of axial skeleton
has exact synonym: thoracic skeleton
has_obo_namespace: uberon
id: UBERON:0014477
in subset: pheno slim

primordial vasculature
type: Class
equivalent class: Class
  intersection of: primordium
  intersection of: Restriction
    on property: has potential to develop into
    some values from: vasculature
subclass of: primordium
subclass of: Restriction
  on property: part of
  some values from: embryonic cardiovascular system
subclass of: Restriction
  on property: has potential to develop into
  some values from: vasculature
definition: A portion of tissue that will develop into vasculature.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: EFO:0003708
database_cross_reference: TAO:0005076
database_cross_reference: ZFA:0005076
has_obo_namespace: uberon
id: UBERON:0014903

lateral structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: in_lateral_side_of
    some values from: material anatomical entity
subclass of: anatomical structure
subclass of: Restriction
  on property: in_lateral_side_of
  some values from: material anatomical entity
definition: Any structure that is placed on one side of the left-right axis of a bilaterian.
curator note: This class is primarily to implement taxon constraints. It may be removed in the future.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0015212
in subset: grouping class
in subset: non informative

circulatory organ
type: Class
subclass of: compound organ
subclass of: Restriction
  on property: part of
  some values from: circulatory system
definition: A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: heart
database_cross_reference: SPD:0000130
has exact synonym: cardiac pump
has exact synonym: heart or heart like organ
has_narrow_synonym: circulatory vessel
has_obo_namespace: uberon
has_related_synonym: cardiac structure
id: UBERON:0015228
in subset: grouping class

heart plus pericardium
type: Class
subclass of: thoracic cavity element
subclass of: Restriction
  on property: part of
  some values from: cardiovascular system
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: MA:0002449
has exact synonym: heart/pericardium
has_obo_namespace: uberon
id: UBERON:0015410

future central nervous system
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: central nervous system
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: future nervous system
subclass of: Restriction
  on property: develops_from
  some values from: ectoderm
subclass of: Restriction
  on property: has potential to develop into
  some values from: central nervous system
definition: Primordium that develops into the central nervous system
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: UBERON:3000469
has exact synonym: future CNS
has exact synonym: presumptive central nervous system
has_obo_namespace: uberon
id: UBERON:0016879

future nervous system
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: nervous system
subclass of: presumptive structure
subclass of: Restriction
  on property: part of
  some values from: embryo
subclass of: Restriction
  on property: has potential to develop into
  some values from: nervous system
subclass of: Restriction
  on property: existence starts during or after
  some values from: organogenesis stage
definition: Primordium that develops into the nervous system
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: UBERON:3000477
database_cross_reference: AAO:0000477
has exact synonym: presumptive nervous system
has_obo_namespace: uberon
id: UBERON:0016880

entire extraembryonic component
type: Class
subclass of: multi-tissue structure
subclass of: Restriction
  on property: part of
  some values from: conceptus
subclass of: Restriction
  on property: adjacent_to
  some values from: embryonic structure
subclass of: Restriction
  on property: existence starts and ends during
  some values from: embryo stage
definition: The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO:0000195
database_cross_reference: EHDAA2:0000003
database_cross_reference: EMAPA:16042
has exact synonym: extra-embryonic component
has exact synonym: extraembryonic component
has_obo_namespace: uberon
id: UBERON:0016887

transitional anatomical structure
type: Class
subclass of: developing anatomical structure
definition: An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO:0000132
has_obo_namespace: uberon
id: UBERON:0016888

developing mesenchymal structure
type: Class
equivalent class: Class
  intersection of: developing anatomical structure
  intersection of: Restriction
    on property: composed primarily of
    some values from: mesenchyme
subclass of: developing anatomical structure
subclass of: Restriction
  on property: composed primarily of
  some values from: mesenchyme
definition: A mesenchyme-derived anatomical entity undergoing a transtion to become another structure.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: AEO:0001016
has_obo_namespace: uberon
id: UBERON:0017650

nursing stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: post-embryonic stage
subclass of: Restriction
  on property: has part
  some values from: neonate stage
definition: A mammalian developmental stage that covers the period from birth until weaning.
imported from: oae.owl
imported from: uberon.owl
has exact synonym: suckling stage
has_obo_namespace: uberon
id: UBERON:0018685

infant stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part of
  some values from: nursing stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: neonate stage
definition: Nursing stage that follows the neonate stage in mammals and ends at weaning.
imported from: oae.owl
imported from: uberon.owl
Contributor: ANiknejad
Contributor: cmungall
has_obo_namespace: uberon
id: UBERON:0034920

multi organ part structure
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: composed primarily of
  some values from: organ part
definition: An multicellular anatomical structure that has subparts of multiple organs as a part.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: CARO:0020001
has_obo_namespace: uberon
has_related_synonym: anatomical cluster
id: UBERON:0034921

cell cluster
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: surrounded by
  some values from: anatomical boundary
definition: A cluster of cells, largely surrounded by a morphological boundary.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: CARO:0020002
database_cross_reference: FMA:62807
has_obo_namespace: uberon
id: UBERON:0034922

anatomical collection
type: Class
subclass of: material anatomical entity
subclass of: Restriction
  on property: has member
  some values from: anatomical structure
definition: A collection of anatomical structures that are alike in terms of their morphology or developmental origin.
editor note: resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0034925

zone of organ
type: Class
subclass of: organ part
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:55268
has exact synonym: organ sector
has exact synonym: organ zonal region
has exact synonym: organ zone
has_obo_namespace: uberon
has_related_synonym: organ region with floating fiat boundary
id: UBERON:0034944

epithelial layer of duct
type: Class
equivalent class: Class
  intersection of: epithelium
  intersection of: Restriction
    on property: part of
    some values from: duct
subclass of: epithelial tube
subclass of: Restriction
  on property: part of
  some values from: duct
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1512086
database_cross_reference: C25787
has_obo_namespace: uberon
has_related_synonym: duct epithelium
has_related_synonym: ductal epithelium
id: UBERON:0034969

future mouth
type: Class
subclass of: embryonic structure
subclass of: subdivision of tube
subclass of: Restriction
  on property: part of
  some values from: presumptive gut
subclass of: Restriction
  on property: has part
  some values from: endoderm
subclass of: Restriction
  on property: has part
  some values from: stomodeum
definition: The primordial mouth region of the developing head.
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: FMA:293105
has exact synonym: primitive mouth
has exact synonym: primordial mouth
has_obo_namespace: uberon
id: UBERON:0035804

external integument structure
type: Class
equivalent class: Class
  intersection of: surface structure
  intersection of: Restriction
    on property: part of
    some values from: integument
subclass of: surface structure
subclass of: Restriction
  on property: part of
  some values from: integument
definition: Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument.
imported from: oae.owl
imported from: uberon.owl
provenance notes: This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon
created by: amphibian_anatomy_curators
has_obo_namespace: uberon/phenoscape-anatomy

time unit
type: Class
subclass of: measurement unit label
editor preferred label: time unit
definition: A unit which is a standard measure of the dimension in which events occur in sequence.
imported from: iao.owl
imported from: uo.owl

vaccine
type: Class
subclass of: processed material
definition: A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine.
imported from: oae.owl
imported from: vo.owl

vaccination
type: Class
subclass of: medical intervention
definition: a medical intervention that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intent to invoke an adaptive immune response.
imported from: oae.owl
imported from: vo.owl

Europe
type: NamedIndividual
located_in: Eurasia
has_obo_namespace: GAZ
id: GAZ:00000464

Asia
type: NamedIndividual
located_in: Eurasia
definition: Part of the landmass of Eurasia, with the western portion of the latter occupied by Europe, lying east of the Suez Canal, east of the Ural Mountains, and south of the Caucasus Mountains and the Caspian and Black Seas. It is bounded on the east by the Pacific Ocean, on the south by the Indian Ocean, and on the north by the Arctic Ocean.
has_obo_namespace: GAZ
id: GAZ:00000465

East Asia
type: NamedIndividual
located_in: Asia
has_obo_namespace: GAZ
id: GAZ:00002471

United Kingdom
type: NamedIndividual
located_in: British Isles
definition: A sovereign island country located off the northwestern coast of mainland Europe comprising of the four constituent countries; England, Scotland, Wales and Northern Ireland. It comprises the island of Great Britain, the northeast part of the island of Ireland and many small islands. Apart from Northern Ireland the UK is surrounded by the Atlantic Ocean, the North Sea, the English Channel and the Irish Sea. The largest island, Great Britain, is linked to France by the Channel Tunnel.
database_cross_reference: ISO3166-1:826
database_cross_reference: ISO3166-1:GB
database_cross_reference: ISO3166-1:GBR
database_cross_reference: ISO3166-2:GB
has exact synonym: Britain
has exact synonym: G.B
has exact synonym: GB
has exact synonym: U.K. {abbrevation}
has exact synonym: UK
has exact synonym: United Kingdom of Great Britain and Northern Ireland
has_obo_namespace: GAZ
id: GAZ:00002637

Japan
type: NamedIndividual
located_in: East Asia
definition: An island country in East Asia. Located in the Pacific Ocean, it lies to the east of China, Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea in the south.
has exact synonym: Nippon-koku
has_obo_namespace: GAZ
id: GAZ:00002747

China
type: NamedIndividual
type: national geopolitical entity
located_in: Northeast Asia
definition: A large country in Northeast Asia. China borders 14 nations (counted clockwise from south): Vietnam, Laos, Burma, India, Bhutan, Nepal, Pakistan, Afghanistan, Tajikistan, Kyrgyzstan, Kazakhstan, Russia, Mongolia and North Korea. Additionally the border between PRC and ROC is located in territorial waters. The People's Republic of China has administrative control over twenty-two provinces and considers Taiwan to be its twenty-third province. There are also five autonomous regions, each with a designated minority group; four municipalities; and two Special Administrative Regions that enjoy considerable autonomy. The People's Republic of China administers 33 province-level regions, 333 prefecture-level regions, 2,862 county-level regions, 41,636 township-level regions, and several village-level regions.
has exact synonym: People's Republic of China
has exact synonym: Zhonghua Renmin Gongheguo
has_obo_namespace: GAZ
id: GAZ:00002845

Northeast Asia
type: NamedIndividual
located_in: Asia
has_obo_namespace: GAZ
id: GAZ:00002846

British Isles
type: NamedIndividual
located_in: Europe
definition: A group of islands off the northwest coast of continental Europe that include the islands of Great Britain and Ireland, and over six thousand smaller islands. There are two sovereign states located on the islands: the United Kingdom and the Republic of Ireland. The British Isles also include two dependencies of the United Kingdom: the Isle of Man and, by tradition, the Channel Islands, although the latter are not physically a part of the island group.
created by: michaelashburner
creation date: 2010-05-16T10:11:46Z
has_obo_namespace: GAZ
id: GAZ:00281547

example to be eventually removed
type: NamedIndividual
type: curation status specification
editor preferred label: example to be eventually removed

metadata complete
type: Thing
type: NamedIndividual
type: curation status specification
editor preferred label: metadata complete
definition: Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.

organizational term
type: Thing
type: NamedIndividual
type: curation status specification
editor preferred label: organizational term
definition: Term created to ease viewing/sort terms for development purpose, and will not be included in a release
definition: term created to ease viewing/sort terms for development purpose, and will not be included in a release
definition editor: PERSON:Alan Ruttenberg

ready for release
type: Thing
type: NamedIndividual
type: curation status specification
editor preferred label: ready for release
has curation status: pending final vetting
definition: Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release."

metadata incomplete
type: Thing
type: NamedIndividual
type: curation status specification
editor preferred label: metadata incomplete
definition: Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.

uncurated
type: Thing
type: NamedIndividual
type: curation status specification
editor preferred label: uncurated
definition: Nothing done yet beyond assigning a unique class ID and proposing a preferred term.

pending final vetting
type: Thing
type: NamedIndividual
type: curation status specification
editor preferred label: pending final vetting
definition: All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor.

to be replaced with external ontology term
type: NamedIndividual
type: curation status specification
editor preferred label: to be replaced with external ontology term
definition: Terms with this status should eventually replaced with a term from another ontology.
definition editor: Alan Ruttenberg
definition source: group:OBI

requires discussion
type: NamedIndividual
type: curation status specification
editor preferred label: requires discussion
has curation status: pending final vetting
definition: A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.
definition editor: Alan Ruttenberg
definition source: group:OBI

KPMP organization
type: NamedIndividual
type: organization

participant candidate 1
type: NamedIndividual
type: clinical study participant candidate

participant candidate 2
type: NamedIndividual
type: clinical study participant candidate

participant candidate 3
type: NamedIndividual
type: clinical study participant candidate

filled CRF by candidate 1
type: NamedIndividual
type: CRF filled up by participant candidate
type: Class
  intersection of: Restriction
    on property: has answer
    some values from: yes answer to question
  intersection of: Restriction
    on property: has exclusion question
    some values from: Whether age less than 18 years old
type: Class
  intersection of: Restriction
    on property: has answer
    some values from: no answer to question
  intersection of: Restriction
    on property: has exclusion question
    some values from: Whether BMI greater than 40 kg per m2

filled CRF by candidate 2
type: NamedIndividual
type: CRF filled up by participant candidate
type: Class
  intersection of: Restriction
    on property: has answer
    some values from: no answer to question
  intersection of: Restriction
    on property: has exclusion question
    some values from: Whether age less than 18 years old

filled CRF by candidate 3
type: NamedIndividual
type: CRF filled up by participant candidate
type: Class
  intersection of: Restriction
    on property: has answer
    some values from: yes answer to question
  intersection of: Restriction
    on property: has exclusion question
    some values from: Whether age less than 18 years old

EudraCT
type: NamedIndividual
type: organization
alternative term: European Union Drug Regulating Authorities Clinical Trials
definition source: https://en.wikipedia.org/wiki/EudraCT

Clinicaltrials.gov
type: NamedIndividual
type: organization
definition: ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine.
definition source: https://clinicaltrials.gov/

SDY269 study
type: NamedIndividual
type: investigation

SDY269
type: NamedIndividual
type: study accession identifier
is about: SDY269 study

human subject SUB112829
type: NamedIndividual
type: human subject

axiom holds for all times
type: NamedIndividual
definition: ## Elucidation This is used when the statement/axiom is assumed to hold true 'eternally' ## How to interpret (informal) First the "atemporal" FOL is derived from the OWL using the standard interpretation. This axiom is temporalized by embedding the axiom within a for-all-times quantified sentence. The t argument is added to all instantiation predicates and predicates that use this relation. ## Example Class: nucleus SubClassOf: part_of some cell forall t : forall n : instance_of(n,Nucleus,t) implies exists c : instance_of(c,Cell,t) part_of(n,c,t) ## Notes This interpretation is *not* the same as an at-all-times relation

iao.owl
type: NamedIndividual
default language: en
imported from: bfo.owl
imported from: externalByHand.owl
imported from: iao-main.owl
imported from: iao.owl
imported from: import-OBO.owl
imported from: obsolete.owl
imported from: ontology-metadata.owl
imported from: annotations.owl
imported from: bfo-axioms.owl
imported from: bfo-classes-minimal.owl
imported from: core.owl
Contributor: Adam Goldstein
Contributor: Alan Ruttenberg
Contributor: Albert Goldfain
Contributor: Barry Smith
Contributor: Bjoern Peters
Contributor: Carlo Torniai
Contributor: Chris Mungall
Contributor: Chris Stoeckert
Contributor: Christian A. Boelling
Contributor: Darren Natale
Contributor: David Osumi-Sutherland
Contributor: Gwen Frishkoff
Contributor: Holger Stenzhorn
Contributor: James A. Overton
Contributor: James Malone
Contributor: Jennifer Fostel
Contributor: Jie Zheng
Contributor: Jonathan Rees
Contributor: Larisa Soldatova
Contributor: Lawrence Hunter
Contributor: Mathias Brochhausen
Contributor: Matt Brush
Contributor: Melanie Courtot
Contributor: Michel Dumontier
Contributor: Paolo Ciccarese
Contributor: Pat Hayes
Contributor: Philippe Rocca-Serra
Contributor: Randy Dipert
Contributor: Ron Rudnicki
Contributor: Satya Sahoo
Contributor: Sivaram Arabandi
Contributor: Werner Ceusters
Contributor: William Duncan
Contributor: William Hogan
Contributor: Yongqun (Oliver) He
license: http://creativecommons.org/licenses/by/4.0/
comment: An information artifact is, loosely, a dependent continuant or its bearer that is created as the result of one or more intentional processes. Examples: uniprot, the english language, the contents of this document or a printout of it, the temperature measurements from a weather balloon. For more information, see the project home page at https://github.com/information-artifact-ontology/IAO
comment: IDs allocated to related efforts: PNO: IAO_0020000-IAO_0020999, D_ACTS: IAO_0021000-IAO_0021999
comment: IDs allocated to subdomains of IAO. pno.owl: IAO_0020000-IAO_0020999, d-acts.owl: IAO_0021000-IAO_0021999
comment: The Information Artifact Ontology (IAO) is licensed under the Creative Commons Attribution License (CC-BY) version 4.0. You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially. for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. You must give appropriate credit (by using the original ontology IRI for the whole ontology and original term IRIs for individual terms), provide a link to the license, and indicate if any changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. For more information see http://www.obofoundry.org/docs/Citation.html
comment: This version of the ontology is the merge of all its imports and has added axioms inferred by an OWL reasoner

Ontology for Biomedical Investigations
type: NamedIndividual
default language: en
OBO foundry unique label: Ontology for Biomedical Investigations
Contributor: Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester
creator: Alan Ruttenberg
creator: Allyson Lister
creator: Barry Smith
creator: Bill Bug
creator: Bjoern Peters
creator: Carlo Torniai
creator: Chris Mungall
creator: Chris Stoeckert
creator: Chris Taylor
creator: Christian Bolling
creator: Cristian Cocos
creator: Daniel Rubin
creator: Daniel Schober
creator: Dawn Field
creator: Dirk Derom
creator: Elisabetta Manduchi
creator: Eric Deutsch
creator: Frank Gibson
creator: Gilberto Fragoso
creator: Helen C. Causton
creator: Helen Parkinson
creator: Holger Stenzhorn
creator: James A. Overton
creator: James Malone
creator: Jay Greenbaum
creator: Jeffrey Grethe
creator: Jennifer Fostel
creator: Jessica Turner
creator: Jie Zheng
creator: Joe White
creator: John Westbrook
creator: Kevin Clancy
creator: Larisa Soldatova
creator: Lawrence Hunter
creator: Liju Fan
creator: Luisa Montecchi
creator: Matthew Brush
creator: Matthew Pocock
creator: Melanie Courtot
creator: Melissa Haendel
creator: Mervi Heiskanen
creator: Monnie McGee
creator: Norman Morrison
creator: Philippe Rocca-Serra
creator: Phillip Lord
creator: Pierre Grenon
creator: Richard Bruskiewich
creator: Richard Scheuermann
creator: Robert Stevens
creator: Ryan R. Brinkman
creator: Stefan Wiemann
creator: Susanna-Assunta Sansone
creator: Tanya Gray
creator: Tina Hernandez-Boussard
creator: Trish Whetzel
creator: Yongqun He
date: 2009-07-31
description: The Ontology for Biomedical Investigations (OBI) is build in a collaborative, international effort and will serve as a resource for annotating biomedical investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. This ontology arose from the Functional Genomics Investigation Ontology (FuGO) and will contain both terms that are common to all biomedical investigations, including functional genomics investigations and those that are more domain specific.
Format: OWL-DL
subject: An ontology for the annotation of biomedical and functional genomics experiments.
license: http://creativecommons.org/licenses/by/4.0/
comment: Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them.
version info: 2022-01-03