]> 04-11-2016 A biomedical ontology in the area of vaccine adverse events. Erica Marcos Jiangan Xie OVAE is a biomedical ontology in the area of vaccine adverse events. OVAE is an extension of the community-based Ontology of Adverse Events (OAE). OVAE: Ontology of Vaccine Adverse Events OWL-DL Vision Release: 1.0.34 Yongqun "Oliver" He (YH) BFO OWL specification label BFO OWL specification label BFO OWL specification label Really of interest to developers only Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. BFO CLIF specification label BFO CLIF specification label Person:Alan Ruttenberg BFO CLIF specification label Really of interest to developers only Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 editor preferred term editor preferred term editor preferred term~editor preferred label editor preferred label editor preferred term~editor preferred label PERSON:Daniel Schober editor preferred label editor preferred term GROUP:OBI:<http://purl.obolibrary.org/obo/obi> The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) editor preferred term example of usage example of usage A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober example example of usage has curation status has curation status OBI_0000281 PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot has curation status definition textual definition definition definition definition textual definition definition GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. definition editor note editor note editor note 1 IAO:0000116 editor_note editor_note uberon An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. GROUP:OBI:<http://purl.obfoundry.org/obo/obi> PERSON:Daniel Schober editor note term editor definition editor definition editor term editor 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. GROUP:OBI:<http://purl.obolibrary.org/obo/obi> Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people PERSON:Daniel Schober definition editor term editor alternative term alternative term An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober alternative term definition source definition source Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 curator notes curator note curator note 1 IAO:0000232 curator_notes curator_notes uberon An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg curator note imported from imported from For external terms/classes, the ontology from which the term was imported GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Alan Ruttenberg PERSON:Melanie Courtot imported from expand expression to expand assertion to elucidation elucidation Person:Barry Smith Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms elucidation person:Alan Ruttenberg has associated axiom(nl) has associated axiom(nl) An axiom associated with a term expressed using natural language Person:Alan Ruttenberg Person:Alan Ruttenberg has associated axiom(nl) has associated axiom(fol) has associated axiom(fol) An axiom expressed in first order logic using CLIF syntax Person:Alan Ruttenberg Person:Alan Ruttenberg has associated axiom(fol) Chinese translation YH, JX a chinese translation represents a chinese translation of the existing term. adverse event outcome The AE 'cough AE' has the 'label of AE outcome' of 'cough'; 'infection AE' has the 'label of AE outcom' of 'infection'. an annotation property that represents the label of an adverse event label of adverse event outcome Yongqun Oliver He, Jiangan Hardy Xie organism NCBITaxon ID The NCBITaxon ontology ID of an organism. Oliver He, Yue Liu temporal interpretation https://code.google.com/p/obo-relations/wiki/ROAndTime https://github.com/oborel/obo-relations/wiki/ROAndTime An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. never in taxon x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL. ?X DisjointWith RO_0002162 some ?Y Chris Mungall tooth SubClassOf 'never in taxon' value 'Aves' taxonomic class assertion An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon. dubious_for_taxon 1 1 RO:0002174 S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. dubious_for_taxon dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost uberon present_in_taxon 1 1 RO:0002175 S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S applicable for taxon present_in_taxon present_in_taxon uberon logical macro assertion https://github.com/oborel/obo-relations/wiki/ShortcutRelations An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL. logical macro assertion on a class A logical macro assertion whose domain is an IRI for a class The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL logical macro assertion on a property A logical macro assertion whose domain is an IRI for a property logical macro assertion on an object property logical macro assertion on an annotation property is direct form of Chris Mungall relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q' external_definition 1 An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000001 external_definition external_definition uberon axiom_lost_from_external_ontology 1 A textual description of an axiom loss in this ontology compared to an external ontology. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000002 axiom_lost_from_external_ontology axiom_lost_from_external_ontology uberon homology_notes 1 Notes on the homology status of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000003 homology_notes homology_notes uberon external_comment 1 An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000005 external_comment external_comment uberon implements_design_pattern 1 UBPROP:0000006 implements_design_pattern implements_design_pattern uberon has_relational_adjective 1 UBPROP:0000007 Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. has_relational_adjective has_relational_adjective uberon taxon_notes 1 Notes on the how instances of this class vary across species. UBPROP:0000008 taxon_notes taxon_notes uberon function_notes 1 Notes on the evolved function of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000009 function_notes function_notes uberon structure_notes 1 Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 structure_notes structure_notes uberon development_notes 1 Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 development_notes development_notes uberon external_ontology_notes 1 Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 external_ontology_notes external_ontology_notes uberon terminology_notes 1 Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000013 terminology_notes terminology_notes uberon is count of 1 UBPROP:0000100 is_count_of is_count_of uberon preceding element is 1 A property used in conjunction with repeated_element_number to indicate an axis and directionality along that axis. If P preceding_element_is R, and P is_count_of S, and X P N, and X' P N+1, then it follows that every X R some X', and the class expression [S and R some X' and inv(R) some X] is empty (i.e. X is followed by X', with no intermediates) UBPROP:0000101 preceding_element_is preceding_element_is uberon phalanx number 1 Most land mammals including humans have a 2-3-3-3-3 formula in both the hands (or paws) and feet. Primitive reptiles typically had the formula 2-3-4-4-5, and this pattern, with some modification, remained in many later reptiles and in the mammal-like reptiles. The phalangeal formula in the flippers of cetaceans (marine mammals) is 2-12-8-1 UBPROP:0000105 phalanx_number phalanx_number uberon x phalanx_number N if and only if (i) x is a phalanx, and (ii) x is phalanx number N in a series of phalanges repeated along an prixomo-distal axis, with phalanx_number 1 being the proximalmost phalanx. Note that in humans, the distalmost phalanx has phlanax_number 3, except in ray_number 1, where the distalmost has phalanx_number 2 has_rank has_rank A metadata relation between a class and its taxonomic rank (eg species, family) ncbi_taxonomy eco subset CUMBO developmental_classification A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes. EFO slim derived from the union of EHDAA2 and EMAPA - still to be checked functional_classification Subset consisting of classes creating for grouping purposes A grouping class that depends on an assumption of homology between subclasses classes that have some inconsistency with FMA somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads abstract class brought in to group ontology classes but not informative organs, excluding individual muscles and skeletal elements Phenotype slim Uberon slim - subset that excludes obscure terms and deep compositional terms abstract upper-level terms not directly useful for analysis core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO contributor 1 dc-contributor dc-contributor uberon creator Source Source subset_property has_alternative_id has_alternative_id has_broad_synonym has_broad_synonym database_cross_reference database_cross_reference has_exact_synonym has_exact_synonym has_narrow_synonym has_narrow_synonym has_obo_namespace has_obo_namespace has_related_synonym has_related_synonym in_subset in_subset shorthand shorthand label depicted_by 1 foaf-depicted_by foaf-depicted_by uberon part of part of BFO:0000050 part_of part_of uberon Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime a core relation that holds between a part and its whole http://www.obofoundry.org/ro/#OBO_REL:part_of is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) part_of this day is part of this year (occurrent parthood) has part has part BFO:0000051 has_part has_part uberon Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime a core relation that holds between a whole and its part has part has_part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) inheres in at all times inheresInAt BFO2 Reference: independent continuant that is not a spatial region inheres-in_at BFO2 Reference: specifically dependent continuant Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'inheres in at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'inheres in@en(x,y,t)'. (iff (inheresInAt a b t) (and (DependentContinuant a) (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))) // axiom label in BFO2 CLIF: [051-002] BFO 2 Reference: Inherence is a subrelation of s-depends_on which holds between a dependent continuant and an independent continuant that is not a spatial region. Since dependent continuants cannot migrate from one independent continuant bearer to another, it follows that if b s-depends_on independent continuant c at some time, then b s-depends_on c at all times at which a exists. Inherence is in this sense redundantly time-indexed.For example, consider the particular instance of openness inhering in my mouth at t as I prepare to take a bite out of a donut, followed by a closedness at t+1 when I bite the donut and start chewing. The openness instance is then shortlived, and to say that it s-depends_on my mouth at all times at which this openness exists, means: at all times during this short life. Every time you make a fist, you make a new (instance of the universal) fist. (Every time your hand has the fist-shaped quality, there is created a new instance of the universal fist-shaped quality.) b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002]) realized in Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) is realized by realized in realized_in this disease is realized in this disease course this fragility is realized in this shattering this investigator role is realized in this investigation realizes Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realizes this disease course realizes this disease this investigation realizes this investigator role this shattering realizes this fragility to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) concretized by at some time [copied from inverse property 'concretizes at some time'] You may concretize a recipe that you find in a cookbook by turning it into a plan which exists as a realizable dependent continuant in your head. concretized-by_st [copied from inverse property 'concretizes at some time'] You may concretize a piece of software by installing it in your computer [copied from inverse property 'concretizes at some time'] b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002]) [copied from inverse property 'concretizes at some time'] you may concretize a poem as a pattern of memory traces in your head [copied from inverse property 'concretizes at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'concretizes at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'concretizes@en'(x,y,t) preceded_by preceded by BFO:0000062 X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) is preceded by preceded_by preceded_by takes place after uberon An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. http://www.obofoundry.org/ro/#OBO_REL:preceded_by is preceded by preceded by preceded_by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. precedes precedes BFO:0000063 precedes precedes uberon precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. occurs in Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t occurs-in occurs in occursIn b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t [XXX-001 occurs_in unfolds in unfolds_in contains process Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t site of specifically depends on at all times (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] BFO2 Reference: specifically dependent continuant\; process; process boundary s-depends-on_at (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] A pain s-depends_on the organism that is experiencing the pain BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28 If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) a gait s-depends_on the walking object. (All at some specific time.) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell reciprocal s-dependence between occurrents: a process of buying and the associated process of selling specificallyDependsOn (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'specifically depends on at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'specifically depends on@en(x,y,t)'. (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20 BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place. If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64 a shape s-depends_on the shaped object an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball the one-sided dependence of an occurrent on an independent continuant: handwave on a hand the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45 the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45 the two-sided reciprocal s-dependence of the roles of husband and wife [20 occupies spatial region at some time located-at-r_st (forall (x y r_1 t) (if (and (occupiesSpatialRegionAt x r_1 t) (continuantPartOfAt y x t)) (exists (r_2) (and (continuantPartOfAt r_2 r_1 t) (occupiesSpatialRegionAt y r_2 t))))) // axiom label in BFO2 CLIF: [043-001] BFO2 Reference: independent continuant Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t) (forall (x r t) (if (occupiesSpatialRegionAt x r t) (and (SpatialRegion r) (IndependentContinuant x)))) // axiom label in BFO2 CLIF: [041-002] BFO2 Reference: spatial region (forall (r t) (if (Region r) (occupiesSpatialRegionAt r r t))) // axiom label in BFO2 CLIF: [042-002] b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002]) every region r is occupies_spatial_region r at all times. (axiom label in BFO2 Reference: [042-002]) if b occupies_spatial_region r at t & b continuant_part_of b at t, then there is some r which is continuant_part_of r at t such that b occupies_spatial_region r at t. (axiom label in BFO2 Reference: [043-001]) occupiesSpatialRegionAt exists at BFO2 Reference: entity b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002]) existsAt BFO2 Reference: temporal region exists-at has occurrent part [copied from inverse property 'part of occurrent'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of occurrent'] b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002]) [copied from inverse property 'part of occurrent'] Mary’s 5th birthday occurrent_part_of Mary’s life [copied from inverse property 'part of occurrent'] The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football. b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) o-has-part (iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001] [copied from inverse property 'part of occurrent'] BFO2 Reference: occurrent hasOccurrentPart [copied from inverse property 'part of occurrent'] the first set of the tennis match occurrent_part_of the tennis match. has proper occurrent part o-has-ppart hasProperOccurrentPart [copied from inverse property 'proper part of occurrent'] b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001]) b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001 has spatial occupant at some time r-location-of_st [copied from inverse property 'occupies spatial region at some time'] b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002]) [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: independent continuant [copied from inverse property 'occupies spatial region at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t) [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: spatial region has spatiotemporal occupant [copied from inverse property 'occupies spatiotemporal region'] BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region. occupied-by [copied from inverse property 'occupies spatiotemporal region'] p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003]) occupies spatiotemporal region occupiesSpatiotemporalRegion BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region. occupies p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003]) part of occurrent BFO2 Reference: occurrent occurrentPartOf o-part-of (forall (x y t) (if (and (occurrentPartOf x y t) (not (= x y))) (exists (z) (and (occurrentPartOf z y t) (not (exists (w) (and (occurrentPartOf w x t) (occurrentPartOf w z t)))))))) // axiom label in BFO2 CLIF: [124-001] (forall (x y t) (if (and (occurrentPartOf x y t) (occurrentPartOf y x t)) (= x y))) // axiom label in BFO2 CLIF: [123-001] [copied from inverse property 'has occurrent part'] b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) (forall (x) (if (Occurrent x) (occurrentPartOf x x))) // axiom label in BFO2 CLIF: [113-002] (forall (x y z) (if (and (occurrentPartOf x y) (occurrentPartOf y z)) (occurrentPartOf x z))) // axiom label in BFO2 CLIF: [112-001] (forall (x y t) (if (exists (v) (and (occurrentPartOf v x t) (occurrentPartOf v y t))) (exists (z) (forall (u w) (iff (iff (occurrentPartOf w u t) (and (occurrentPartOf w x t) (occurrentPartOf w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [125-001] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. Mary’s 5th birthday occurrent_part_of Mary’s life The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football. b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002]) occurrent_part_of is antisymmetric. (axiom label in BFO2 Reference: [123-001]) occurrent_part_of is reflexive (every occurrent entity is an occurrent_part_of itself). (axiom label in BFO2 Reference: [113-002]) occurrent_part_of is transitive. (axiom label in BFO2 Reference: [112-001]) occurrent_part_of satisfies unique product. (axiom label in BFO2 Reference: [125-001]) occurrent_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [124-001]) the first set of the tennis match occurrent_part_of the tennis match. temporal part of (iff (properTemporalPartOf a b) (and (temporalPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [116-001] (forall (x y) (if (properTemporalPartOf x y) (exists (z) (and (properTemporalPartOf z y) (not (exists (w) (and (temporalPartOf w x) (temporalPartOf w z)))))))) // axiom label in BFO2 CLIF: [117-002] b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003]) temporalPartOf t-part-of (iff (temporalPartOf a b) (and (occurrentPartOf a b) (exists (t) (and (TemporalRegion t) (occupiesSpatioTemporalRegion a t))) (forall (c t_1) (if (and (Occurrent c) (occupiesSpatioTemporalRegion c t_1) (occurrentPartOf t_1 r)) (iff (occurrentPartOf c a) (occurrentPartOf c b)))))) // axiom label in BFO2 CLIF: [078-003] b proper_temporal_part_of c =Def. b temporal_part_of c & not (b = c). (axiom label in BFO2 Reference: [116-001]) if b proper_temporal_part_of c, then there is some d which is a proper_temporal_part_of c and which shares no parts with b. (axiom label in BFO2 Reference: [117-002]) the 4th year of your life is a temporal part of your life\. The first quarter of a game of football is a temporal part of the whole game\. The process of your heart beating from 4pm to 5pm today is a temporal part of the entire process of your heart beating.\ The 4th year of your life is a temporal part of your life the process boundary which separates the 3rd and 4th years of your life. your heart beating from 4pm to 5pm today is a temporal part of the process of your heart beating projects onto spatial region at some time st-projects-onto-s_st spatial projection of spatiotemporal at some time s-projection-of-st_st projects onto temporal region st-projects-onto-t temporal projection of spatiotemporal t-projection-of-st occupies temporal region spans occupiesTemporalRegion p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) has temporal occupant [copied from inverse property 'occupies temporal region'] p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) span-of spanOf during which exists [copied from inverse property 'exists at'] BFO2 Reference: entity during-which-exists [copied from inverse property 'exists at'] BFO2 Reference: temporal region [copied from inverse property 'exists at'] b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002]) specifically depends on at some time s-depends-on_st BFO2 Reference: specifically dependent continuant\; process; process boundary (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'specifically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'specifically depends on@en'(x,y,t) (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] A pain s-depends_on the organism that is experiencing the pain BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28 BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20 BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place. If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64 a gait s-depends_on the walking object. (All at some specific time.) a shape s-depends_on the shaped object an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat reciprocal s-dependence between occurrents: a process of buying and the associated process of selling specificallyDependsOn one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball the one-sided dependence of an occurrent on an independent continuant: handwave on a hand the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45 the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45 the two-sided reciprocal s-dependence of the roles of husband and wife [20 part of continuant at some time (forall (x y t) (if (and (continuantPartOfAt x y t) (IndependentContinuant x)) (locatedInAt x y t))) // axiom label in BFO2 CLIF: [047-002] [copied from inverse property 'has continuant part at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t) BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'has continuant part at some time'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) (forall (x y t) (if (and (continuantPartOfAt x y t) (not (= x y))) (exists (z) (and (continuantPartOfAt z y t) (not (exists (w) (and (continuantPartOfAt w x t) (continuantPartOfAt w z t)))))))) // axiom label in BFO2 CLIF: [121-001] (iff (ImmaterialEntity a) (and (IndependentContinuant a) (not (exists (b t) (and (MaterialEntity b) (continuantPartOfAt b a t)))))) // axiom label in BFO2 CLIF: [028-001] (forall (x t) (if (Continuant x) (continuantPartOfAt x x t))) // axiom label in BFO2 CLIF: [111-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y x t)) (= x y))) // axiom label in BFO2 CLIF: [120-001] (forall (x y z t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y z t)) (continuantPartOfAt x z t))) // axiom label in BFO2 CLIF: [110-001] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) c-part-of_st BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. BFO2 Reference: continuant (forall (x y t) (if (exists (v) (and (continuantPartOfAt v x t) (continuantPartOfAt v y t))) (exists (z) (forall (u w) (iff (iff (continuantPartOfAt w u t) (and (continuantPartOfAt w x t) (continuantPartOfAt w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [122-001] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation continuantPartOfAt Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t) b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) continuant_part_of is antisymmetric. (axiom label in BFO2 Reference: [120-001]) continuant_part_of is reflexive (every continuant entity is a continuant_part_of itself). (axiom label in BFO2 Reference: [111-002]) continuant_part_of is transitive. (axiom label in BFO2 Reference: [110-001]) continuant_part_of satisfies unique product. (axiom label in BFO2 Reference: [122-001]) continuant_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [121-001]) if b continuant_part_of c at t and b is an independent continuant, then b is located_in c at t. (axiom label in BFO2 Reference: [047-002]) the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. has continuant part at some time [copied from inverse property 'part of continuant at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t) [copied from inverse property 'part of continuant at some time'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) [copied from inverse property 'part of continuant at some time'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation (iff (hasContinuantPartAt a b t) (continuantPartOfAt b a t)) // axiom label in BFO2 CLIF: [006-001] c-has-part_st Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t) [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuant [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. hasContinuantPartAt [copied from inverse property 'part of continuant at some time'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) part of continuant at all times that whole exists [copied from inverse property 'has continuant part at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has continuant part at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has continuant part@en(x,y,t)'. This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'has continuant part at all times' forall(t) exists_at(y,t) -> exists_at(x,t) and 'part of continuant'(x,y,t) [copied from inverse property 'has continuant part at all times'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) c-part-of-object_at has continuant part at all times that part exists [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuant [copied from inverse property 'part of continuant at all times'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. c-has-part-object_at forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t) [copied from inverse property 'part of continuant at all times'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) [copied from inverse property 'part of continuant at all times'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'part of continuant at all times' [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'part of continuant at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'part of continuant at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'part of continuant@en(x,y,t)'. [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. anterior_to 2009-07-31T02:15:46Z BSPO:0000096 anterior_to anterior_to cjm uberon x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer distal_to BSPO:0000097 distal_to distal_to uberon x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal). dorsal_to BSPO:0000098 dorsal_to dorsal_to uberon x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). posterior_to BSPO:0000099 caudal_to posterior_to posterior_to uberon x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. proximal_to BSPO:0000100 proximal_to proximal_to uberon x proximal_to y iff x is closer to the point of attachment with the body than y. ventral_to BSPO:0000102 uberon ventral_to ventral_to x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). deep_to BSPO:0000107 Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. deep_to deep_to uberon superficial_to BSPO:0000108 Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. superficial_to superficial_to uberon in_left_side_of BSPO:0000120 X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern in_left_side_of in_left_side_of uberon in_right_side_of BSPO:0000121 X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern in_right_side_of in_right_side_of uberon in_anterior_side_of BSPO:0000123 X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. in_anterior_side_of in_anterior_side_of uberon in_proximal_side_of BSPO:0000124 X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. in_proximal_side_of in_proximal_side_of uberon in_distal_side_of BSPO:0000125 X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. in_distal_side_of in_distal_side_of uberon in_lateral_side_of BSPO:0000126 X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern in_lateral_side_of in_lateral_side_of uberon proximalmost_part_of BSPO:0001106 X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y proximalmost_part_of proximalmost_part_of uberon is evidence of This represents a relation between two adverse events AE1 and AE2. However, AE1 may be an evidence of another adverse event AE3, and a dfferent adverse event AE4 may also be an evidence of the same AE2. SS, YH, YL An electrocardiogram qt prolonged AE is_evidence_of arrhythmia AE; arrhythmia AE is_evidence_of cardiomyopathy AE; fever AE is_evidence_of inflammation AE; fever AE is_evidence_of viral infection AE; plural effusion AE is_evidence_of cardiac disorder AE. has participant quality an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased. Yongqun He adverse event occurs in a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. Yongqun He is_specified_input_of PERSON:Bjoern Peters A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. Alan Ruttenberg is_specified_input_of some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay is_manufactured_by Alan Ruttenberg Liju Fan c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this. has_make has_manufacturer http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities) is_manufactured_by is_specified_output_of PERSON:Bjoern Peters A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. Alan Ruttenberg is_specified_output_of achieves_planned_objective A cell sorting process achieves the objective specification 'material separation objective' BP, AR, PPPB branch PPPB branch derived This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. achieves_planned_objective modified according to email thread from 1/23/09 in accordince with DT and PPPB branch is genome of organism a 'part of continuant at some time' relation that incides a genome belongs to a organism. Yongqun He, Bin Zhao is gene of organism Oliver He, Yue Liu a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method. occurs in population an vaccine adverse event 'occurs in population' human vaccinee population is equivalent to say: 'occurs in' human vaccinee 'part of' human vaccine population. an 'occurs in' relation that is a shortcut relation combining the 'occurs in' relation in an specific term which is part of a population. Yongqun He participates in a relation between a continuant and a process, in which the continuant is somehow involved in the process participates in participates_in this blood clot participates in this blood coagulation this input material (or this output material) participates in this process this investigator participates in this investigation has participant Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. a relation between a process and a continuant, in which the continuant is somehow involved in the process has participant http://www.obofoundry.org/ro/#OBO_REL:has_participant has_participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) concretizes A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant). A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process). has function A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence has_function this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) has quality A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence has_quality this apple has quality this red color has role A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence has_role this person has role this investigator role (more colloquially: this person has this role of investigator) location_of RO:0001015 location_of location_of uberon located_in located in RO:0001025 located_in located_in uberon http://www.obofoundry.org/ro/#OBO_REL:located_in Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime a relation between two independent continuants, the target and the location, in which the target is entirely within the location located in located_in my brain is located in my head this rat is located in this cage has boundary RO:0002002 has_boundary has_boundary uberon bounding layer of A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. RO:0002007 bounding_layer_of bounding_layer_of uberon before or simultaneous with <= David Osumi-Sutherland Primitive instance level timing relation between events simultaneous_with simultaneous with RO:0002082 Relation between occurrents, shares start and end boundaries. coincides_with is_equal_to simultaneous_with simultaneous_with uberon David Osumi-Sutherland t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) ends after David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) immediately_preceded_by immediately preceded by A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]. RO:0002087 X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) directly preceded by immediately_preceded_by immediately_preceded_by is directly preceded by is immediately preceded by starts_at_end_of uberon starts_at_end_of David Osumi-Sutherland X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately precedes ends_at_start_of meets David Osumi-Sutherland X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) starts during David Osumi-Sutherland X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y)) io happens during X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) d during David Osumi-Sutherland ends during David Osumi-Sutherland o overlaps X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). overlaps http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) x overlaps y if and only if there exists some z such that x has part z and z part of y continuous_with RO:0002150 continuous_with continuous_with uberon homologous_to RO:0002158 homologous_to homologous_to uberon connected to Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. Connection does not imply overlaps. RO:0002170 connected_to connected_to uberon connects Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. RO:0002176 connects connects this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect) uberon develops_from RO:0002202 develops_from develops_from uberon develops_into RO:0002203 develops_into develops_into uberon surrounded_by RO:0002219 surrounded_by surrounded_by uberon x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y adjacent_to RO:0002220 adjacent_to adjacent_to uberon x adjacent_to y iff: x and y share a boundary surrounds RO:0002221 inverse of surrounded_by surrounds surrounds uberon temporally related to https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. starts RO:0002223 Relation between occurrents, shares a start boundary with. starts starts uberon starts with starts with RO:0002224 starts_with starts_with uberon started by x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor Chris Mungall ends RO:0002229 Relation between occurrents, shares an end boundary with. ends ends finishes uberon ends with ends with RO:0002230 ends_with ends_with uberon Chris Mungall finished by x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. has developmental contribution from RO:0002254 has_developmental_contribution_from has_developmental_contribution_from uberon developmentally_induced_by RO:0002256 developmentally_induced_by developmentally_induced_by sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F) t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. uberon developmentally preceded by RO:0002258 developmentally_preceded_by developmentally_preceded_by uberon developmentally_replaces RO:0002285 developmentally_replaces developmentally_replaces uberon mereotopologically related to A mereological relationship or a topological relationship Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships has member RO:0002351 has_member has_member uberon has potential to developmentally contribute to RO:0002385 has_potential_to_developmentally_contribute_to has_potential_to_developmentally_contribute_to uberon x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y has potential to develop into RO:0002387 has_potential_to_develop_into has_potential_to_develop_into uberon x has the potential to develop into y iff x develops into y or if x is capable of developing into y contributes to morphology of RO:0002433 contributes_to_morphology_of contributes_to_morphology_of uberon composed primarily of RO:0002473 UBREL:0000002 composed_primarily_of composed_primarily_of uberon x composed_primarily_of y iff: more than half of the mass of x is made from parts of y existence starts during BFO:0000068 RO:0002488 Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. begins_to_exist_during existence_starts_during existence_starts_during uberon existence starts with RO:0002489 Relation between continuant and occurrent, such that c comes into existence at the start of p. existence_starts_with existence_starts_with uberon existence ends during BFO:0000069 RO:0002492 Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. ceases_to_exist_during existence_ends_during existence_ends_during uberon existence ends with RO:0002493 Relation between continuant and occurrent, such that c ceases to exist at the end of p. existence_ends_with existence_ends_with uberon transformation of RO:0002494 transformation_of transformation_of transforms from uberon immediate transformation of RO:0002495 direct_transformation_of immediate_transformation_of immediate_transformation_of immediately transforms from uberon existence starts during or after RO:0002496 existence_starts_during_or_after existence_starts_during_or_after uberon existence ends during or before RO:0002497 existence_ends_during_or_before existence_ends_during_or_before uberon has material contribution from RO:0002507 has_material_contribution_from has_material_contribution_from uberon has skeleton A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. RO:0002551 has sekeletal support has supporting framework has_skeleton has_skeleton uberon luminal space of RO:0002572 luminal_space_of luminal_space_of uberon skeleton of RO:0002576 skeleton_of skeleton_of uberon produces RO:0003000 produces produces uberon produced_by RO:0003001 produced_by produced_by uberon has vaccine contraindication This relation may be replaced by has_vaccine_allergen. We need to determine if any vaccine contraindicator is not a vaccine allergen. YH has_vaccine_contraindication is a relation that specifies contraindication of a vaccine. has vaccine allergen a object property that specifies a relation between a vaccine and a vaccine allergen YH vaccinated in route an object property that specifies a relation between a vaccine and a vaccinate route is_distributed_by is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product. YH, ZX vaccine immunization for host Yongqun He YL vaccine immunization against microbe Yongqun He anteriorly connected to anteriorly_connected_to uberon x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. channel for carries channel_for uberon conduit for conduit_for uberon x is a conduit for y iff y passes through the lumen of x. distally connected to distally_connected_to uberon x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. evolved_from Status: experimental evolved_from uberon existence starts and ends during existence_starts_and_ends_during uberon extends_fibers_into extends_fibers_into uberon in_central_side_of X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern in_central_side_of uberon posteriorly connected to posteriorly_connected_to uberon x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. protects protects uberon proximally connected to proximally_connected_to uberon x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. subdivision of placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B subdivision_of uberon transitively anteriorly connected to . transitively_anteriorly_connected_to uberon transitively_connected to transitively_connected_to uberon transitively distally connected to . transitively_distally_connected_to uberon transitively proximally connected to . transitively_proximally_connected_to uberon has VAE occurrence a data property that indicates a vaccinee having an occurrence of a specific VAE of a particular data value that is in the range of 0 and 1. Yongqun He has age in year Yongqun He a data property that represents the age with the unit of year. entity entity entity BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf Julius Caesar Verdi’s Requiem entity the Second World War your body mass index continuant continuant Continuant (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) continuant (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants continuant if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) occurrent (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] An entity that has temporal parts and that happens, unfolds or develops through time. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. occurrent Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) occurrent independent continuant IndependentContinuant (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) a leg a molecule an atom an organism ic a chair a heart a spatial region an orchestra. b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) independent continuant the bottom right portion of a human torso the interior of your mouth dependent continuant A continuant that is either dependent on one or other independent continuant bearers or inheres in or is borne by other entities. spatial region true true (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] s-region BFO 2 Reference: Spatial regions do not participate in processes. Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional. SpatialRegion (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001]) All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001]) temporal region true true (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional TemporalRegion t-region (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) spatiotemporal region true true st-region (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001]) Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002]) SpatiotemporalRegion (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001]) Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001]) Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001]) Every spatiotemporal region occupies_spatiotemporal_region itself. the spatiotemporal region occupied by a human life the spatiotemporal region occupied by a process of cellular meiosis. the spatiotemporal region occupied by the development of a cancer tumor process (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. process Process BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) process the course of a disease the flight of a bird the life of an organism your process of aging. disposition (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] Disposition (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type [89 BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. an atom of element X has the disposition to decay to an atom of element Y disposition If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocitosis and exocitosis the cell wall is disposed to filter chemicals in endocytosis and exocytosis realizable entity A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) RealizableEntity realizable (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) realizable entity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet quality (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] quality Quality (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril specifically dependent continuant (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] SpecificallyDependentContinuant A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) of one-sided specifically dependent continuants: the mass of this tomato sdc A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. specifically dependent continuant the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. Role role (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) role the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role three-dimensional spatial region ThreeDimensionalSpatialRegion 3d-s-region (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001]) a cube-shaped region of space a sphere-shaped region of space, site (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] Manhattan Canyon) site Site a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) generically dependent continuant gdc (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] GenericallyDependentContinuant A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) generically dependent continuant the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. function (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] Function A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar process boundary (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002]) p-boundary ProcessBoundary p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) the boundary between the 2nd and 3rd year of your life. material entity material (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) MaterialEntity An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) material entity the undetached arm of a human being immaterial entity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial ImmaterialEntity zero-dimensional temporal region (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] ZeroDimensionalTemporalRegion 0d-t-region A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) a temporal region that is occupied by a process boundary right now temporal instant. the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. gross anatomical part Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. gross anatomical part formaldehyde Aldeide formica Beilstein:1209228 CH2O CHEBI:14274 CHEBI:16842 CHEBI:24077 CHEBI:337763 CHEBI:5142 ChEMBL:7381846 ChemIDplus:50-00-0 Chlodithan Chlodithane CiteXplore:110589 CiteXplore:11094105 CiteXplore:11688455 CiteXplore:12101431 CiteXplore:12429629 CiteXplore:12686735 CiteXplore:15091529 CiteXplore:15189269 CiteXplore:15450713 CiteXplore:15810952 CiteXplore:15893897 CiteXplore:15914300 CiteXplore:15975255 CiteXplore:16001656 CiteXplore:16136465 CiteXplore:16149025 CiteXplore:16280667 CiteXplore:16423181 CiteXplore:16481239 CiteXplore:16551731 CiteXplore:17618393 CiteXplore:18837732 CiteXplore:2432751 CiteXplore:25042713 CiteXplore:7548723 CiteXplore:7689168 CiteXplore:7896413 CiteXplore:8204010 CiteXplore:8747965 CiteXplore:9048644 CiteXplore:9686972 DrugBank:DB03843 FORMALDEHYDE FORMALIN Fannoform Formaldehyd Formaldehyde Formalin Formalina Formaline Formalith Formic aldehyde Formol Gmelin:445 HMDB:HMDB01426 InChI=1S/CH2O/c1-2/h1H2 KEGG COMPOUND:50-00-0 KEGG COMPOUND:C00067 KEGG DRUG:D00017 MetaCyc:FORMALDEHYDE Methaldehyde Methanal Methylene glycol Methylene oxide NIST Chemistry WebBook:50-00-0 Oxomethane Oxomethylene PDBeChem:FLH PDBeChem:FOR Paraform Reaxys:1209228 The simplest aldehyde. UM-BBD:c0122 WSFSSNUMVMOOMR-UHFFFAOYSA-N Wikipedia:Formaldehyde [H]C([H])=O chebi_ontology formaldehyde lactose (+)-lactose (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-oxane-3,4,5-triol (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol (2R,3S,4S,5R,6S)-2-methylol-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-methylol-tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol (Gal)1 (Glc)1 1-beta-D-Galactopyranosyl-4-D-glucopyranose 4-(beta-D-galactosido)-D-glucose 4-O-beta-D-galactopyranosyl-D-glucose A disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form. Beilstein:1292745 C12H22O11 CHEBI:10296 CHEBI:10380 CHEBI:14497 CHEBI:17716 CHEBI:22460 CHEBI:22760 CHEBI:25005 CHEBI:27755 CHEBI:613009 ChEMBL:19053747 ChemIDplus:63-42-3 CiteXplore:1292745 CiteXplore:17329833 CiteXplore:18300214 CiteXplore:19846069 CiteXplore:19913595 CiteXplore:20094999 CiteXplore:20503067 CiteXplore:20699559 CiteXplore:20873837 CiteXplore:20961532 CiteXplore:21403918 CiteXplore:2432147 CiteXplore:2456994 CiteXplore:6194884 CiteXplore:7574700 D-lactose GUBGYTABKSRVRQ-QKKXKWKRSA-N Galbeta1-4-Glc Gmelin:882872 InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 KEGG COMPOUND:63-42-3 KEGG COMPOUND:C00243 KEGG DRUG:D00046 KEGG GLYCAN:G10504 KNApSAcK:C00001136 Lac Laktobiose Laktose Milchzucker Milk sugar NIST Chemistry WebBook:63-42-3 OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)OC(O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O Reaxys:1292745 beta-D-Gal-(1->4)-D-Glc beta-D-Galp-(1->4)-D-Glcp beta-D-galactopyranosyl-(1->4)-D-glucopyranose beta-Gal1,4-Glc chebi_ontology lactobiose lactose milk sugar molecular entity . Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. CHEBI:23367 chebi_ontology entidad molecular entidades moleculares entite moleculaire molecular entities molecular entity molekulare Entitaet chemical entity . A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. CHEBI:24431 chebi_ontology chemical entity grouped_by_chemistry glucitol Beilstein:1721909 C6H14O6 CHEBI:15093 CHEBI:26724 CHEBI:26726 CHEBI:30911 CHEBI:33795 CHEBI:33796 CHEBI:9201 Gmelin:83165 Sorbitol Wikipedia:Sorbitol chebi_ontology glucitol gulitol rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol sorbitol sorbitols dextran (1,6-alpha-D-Glucosyl)m (1,6-alpha-D-Glucosyl)m+1 (1,6-alpha-D-Glucosyl)n (1,6-alpha-D-Glucosyl)n+1 1,6-alpha-D-Glucan A (1->6)-alpha-D-glucan which has extra branching consisting of (1->2), (1->3) or (1->4) linkages. CHEBI:52071 ChemIDplus:9004-54-0 CiteXplore:8154046 Dextran 40 Dextran 70 Dextran 75 KEGG COMPOUND:9004-54-0 KEGG COMPOUND:C00372 KEGG DRUG:D00060 KEGG DRUG:D06541 KEGG GLYCAN:G10502 chebi_ontology dextran dextrane dextrano dextrans dextranum neomycin A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections. C22H41N5O13R2.C12H26N4O6 CHEBI:7507 DrugBank:DB00994 KEGG COMPOUND:1404-04-2 KEGG COMPOUND:C00384 KEGG DRUG:D08260 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2[*])[C@H](N)[C@@H](O)[C@@H]1O Neomycin chebi_ontology objective specification 2009-03-16: original definition when imported from OBI read: "objective is an non realizable information entity which can serve as that proper part of a plan towards which the realization of the plan is directed." 2014-03-31: In the example of usage ("In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction") there is a protocol which is the ChIP assay protocol. In addition to being concretized on paper, the protocol can be concretized as a realizable entity, such as a plan that inheres in a person. The objective specification is the part that says that some protein and DNA interactions are identified. This is a specification of a process endpoint: the boundary in the process before which they are not identified and after which they are. During the realization of the plan, the goal is to get to the point of having the interactions, and participants in the realization of the plan try to do that. Answers the question, why did you do this experiment? In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction. OBI Plan and Planned Process/Roles Branch OBI_0000217 PERSON: Alan Ruttenberg PERSON: Barry Smith PERSON: Bjoern Peters PERSON: Jennifer Fostel a directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved. goal specification objective specification information content entity 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ). A generically dependent continuant that is about some thing. Examples of information content entites include journal articles, data, graphical layouts, and graphs. OBI_0000142 PERSON: Chris Stoeckert information content entity directive information entity 2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was "is the specification of a process that can be concretized and realized by an actor" with alternative term "instruction".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term. 2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it. 8/6/2009 Alan Ruttenberg: Changed label from "information entity about a realizable" after discussions at ICBO An information content entity whose concretizations indicate to their bearer how to realize them in a process. PERSON: Alan Ruttenberg PERSON: Bjoern Peters Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan directive information entity Viruses GC_ID:1 Vira Viridae ncbi_taxonomy viruses Poxviridae GC_ID:1 ncbi_taxonomy Chordopoxvirinae GC_ID:1 ncbi_taxonomy Variola virus GC_ID:1 NCBITaxon:12871 ncbi_taxonomy small pox virus smallpox smallpox virus variola virus VAR H5N1 subtype GC_ID:1 H5N1 ncbi_taxonomy Herpesviridae GC_ID:1 ncbi_taxonomy Alphaherpesvirinae GC_ID:1 ncbi_taxonomy Varicellovirus GC_ID:1 ncbi_taxonomy Human herpesvirus 3 GC_ID:1 HHV-3 Human alphaherpesvirus 3 VZV Varicella Zoster Virus Varicella-zoster virus ncbi_taxonomy varicella zoster virus VZV varicella-zoster virus VZV Hepatitis B virus GC_ID:1 HBV Human hepatitis B virus hepatitis B virus (HBV) hepatitis B virus HBV hepatitis B virus, HBV human hepatitis B virus HBV ncbi_taxonomy Adenoviridae GC_ID:1 ncbi_taxonomy Human papillomavirus GC_ID:1 Human Papilloma Virus human papillomavirus HPV ncbi_taxonomy Reoviridae GC_ID:1 ncbi_taxonomy Rotavirus GC_ID:1 Rotaviruses ncbi_taxonomy Togaviridae GC_ID:1 ncbi_taxonomy Rubella virus GC_ID:1 ncbi_taxonomy Flaviviridae Flavivirus (arbovirus group B) GC_ID:1 ncbi_taxonomy Flavivirus GC_ID:1 arboviruses group B ncbi_taxonomy Japanese encephalitis virus group GC_ID:1 Japanese encephalitis viruses ncbi_taxonomy Japanese encephalitis virus GC_ID:1 Japanese encephalitis Japanese encephalitis (JE) virus Japanese encephalitis virus JE Japanese encephalitis virus JEV ncbi_taxonomy Yellow fever virus Flavivirus febricis GC_ID:1 YFV ncbi_taxonomy yellow fever virus YFV Mononegavirales GC_ID:1 ncbi_taxonomy negative-sense genome single-stranded RNA viruses Paramyxoviridae GC_ID:1 ncbi_taxonomy Paramyxovirinae GC_ID:1 ncbi_taxonomy Mumps virus GC_ID:1 ncbi_taxonomy Morbillivirus GC_ID:1 Morbilliviruses ncbi_taxonomy Measles virus Cell-associated subacute sclerosing panencephalitis GC_ID:1 NCBITaxon:11230 Subacute sclerosing panencephalitis virus measles virus MV ncbi_taxonomy rougeole virus rubeola virus subacute sclerose panencephalitis virus subacute sclerosing panencephalitis virus, SSPEV Rhabdoviridae GC_ID:1 PMID:16186241 ncbi_taxonomy Rabies virus GC_ID:1 ncbi_taxonomy Orthomyxoviridae GC_ID:1 ncbi_taxonomy Influenza A virus FLUAV GC_ID:1 Influenza virus type A influenza A virus INF A ncbi_taxonomy Euteleostomi GC_ID:1 NCBITaxon:40673 bony vertebrates ncbi_taxonomy Picornaviridae GC_ID:1 Picormavirus Picornavirus ncbi_taxonomy Human poliovirus 1 GC_ID:1 HPV-1 Human poliovirus type 1 PV1 Poliovirus type 1 ncbi_taxonomy poliovirus type 1 PV1 Human poliovirus 2 GC_ID:1 HPV-2 Human Poliovirus type 2 Poliovirus type 2 ncbi_taxonomy Human poliovirus 3 GC_ID:1 HPV-3 Human poliovirus type 3 Poliovirus type 3 ncbi_taxonomy poliovirus type 3 P3 Hepatitis A virus GC_ID:1 ncbi_taxonomy Proteobacteria GC_ID:11 PMID:11321122 PMID:11542017 PMID:11837318 PMID:16280474 ncbi_taxonomy proteobacteria purple bacteria purple bacteria and relatives purple non-sulfur bacteria purple photosynthetic bacteria purple photosynthetic bacteria and relatives Gammaproteobacteria GC_ID:11 Gammaproteobacteria Garrity et al. 2005 PMID:16280474 Proteobacteria gamma subdivision Purple bacteria, gamma subdivision g-proteobacteria gamma proteobacteria gamma subdivision gamma subgroup ncbi_taxonomy Firmicutes Bacillus/Clostridium group Clostridium group firmicutes Firmacutes GC_ID:11 Gram positive bacteria Gram-positive bacteria Low G+C firmicutes NCBITaxon:31968 PMID:10555317 PMID:11034484 PMID:11542017 PMID:15143038 clostridial firmicutes firmicutes low G+C Gram-positive bacteria low GC Gram+ ncbi_taxonomy Streptococcus GC_ID:11 PMID:10555340 PMID:14657115 PMID:1720654 PMID:7537076 PMID:8995803 ncbi_taxonomy Streptococcus pneumoniae Diplococcus pneumoniae GC_ID:11 Micrococcus pneumoniae ncbi_taxonomy Bacillales Bacillus/Staphylococcus group GC_ID:11 ncbi_taxonomy Human enterovirus C GC_ID:1 NCBITaxon:138953 Poliovirus ncbi_taxonomy Bacillus anthracis Bacillus cereus var. anthracis Bacteridium anthracis GC_ID:11 PMID:8123566 anthrax anthrax bacterium ncbi_taxonomy Clostridium GC_ID:11 ncbi_taxonomy Clostridium tetani Bacillus tetani GC_ID:11 ncbi_taxonomy Papillomaviridae GC_ID:1 PMID:20206957 Papillomavirus ncbi_taxonomy Corynebacterium diphtheriae Bacillus diphtheriae Bacterium diphtheriae GC_ID:11 Microsporon diphthericum Microsporon diphtheriticum Mycobacterium diphtheriae PMID:7729671 Pacinia loeffleri ncbi_taxonomy Influenzavirus A GC_ID:1 ncbi_taxonomy Influenzavirus B GC_ID:1 ncbi_taxonomy Bacteria GC_ID:11 Monera PMID:10425795 PMID:10425796 PMID:10425797 PMID:10490293 PMID:10843050 PMID:10939651 PMID:10939673 PMID:10939677 PMID:11211268 PMID:11321083 PMID:11321113 PMID:11411719 PMID:11540071 PMID:11542017 PMID:11542087 PMID:11760965 PMID:12054223 PMID:2112744 PMID:270744 PMID:8123559 PMID:8590690 PMID:9103655 PMID:9336922 Procaryotae Prokaryota Prokaryotae bacteria eubacteria ncbi_taxonomy not Bacteria Haeckel 1894 prokaryote prokaryotes Eukaryota Eucarya Eucaryotae Eukarya Eukaryotae GC_ID:1 PMID:23020233 eucaryotes eukaryotes eukaryotes ncbi_taxonomy Betaproteobacteria 'Betaproteobacteria' GC_ID:11 Proteobacteria beta subdivision Purple bacteria, beta subdivision b-proteobacteria beta proteobacteria beta subdivision beta subgroup ncbi_taxonomy Euarchontoglires GC_ID:1 PMID:11214319 PMID:12082125 PMID:12878460 PMID:15522813 ncbi_taxonomy Simiiformes Anthropoidea GC_ID:1 ncbi_taxonomy Amniota GC_ID:1 amniotes ncbi_taxonomy Opisthokonta Fungi/Metazoa group GC_ID:1 ncbi_taxonomy opisthokonts Bilateria GC_ID:1 ncbi_taxonomy unclassified Papillomaviridae GC_ID:1 ncbi_taxonomy dsDNA viruses, no RNA stage GC_ID:1 ncbi_taxonomy Retro-transcribing viruses GC_ID:1 Retroid viruses ncbi_taxonomy ssRNA positive-strand viruses, no DNA stage GC_ID:1 ncbi_taxonomy ssRNA negative-strand viruses GC_ID:1 ncbi_taxonomy dsRNA viruses GC_ID:1 dsRNA nonenveloped viruses ncbi_taxonomy Mammalia GC_ID:1 mammals mammals ncbi_taxonomy ssRNA viruses GC_ID:1 ncbi_taxonomy Neisseria meningitidis Diplokokkus intracellularis meningitidis GC_ID:11 Micrococcus intracellularis Micrococcus meningitidis Micrococcus meningitidis cerebrospinalis Neisseria meningitidis. Neisseria weichselbaumii ncbi_taxonomy Bordetella Bordetella Moreno-Lopez 1952 (Approved Lists 1980) emend. Von Wintzingerode et al. 2001 GC_ID:11 PMID:11491321 ncbi_taxonomy Bordetella pertussis Bacterium tussis-convulsivae GC_ID:11 Haemophilus pertussis Hemophilus pertussis Microbe de la coqueluche PMID:8240949 ncbi_taxonomy Enterobacteriaceae Enterobacteraceae Enterobacteraceae (ex Lapage 1979) Lapage 1982, fam. nov., nom. rev. Enterobacteriaceae (ex Rahn 1937) Ewing et al. 1980, fam. nov., nom. rev. Enterobacteriaceae Rahn 1937 GC_ID:11 PMID:10555323 PMID:10555334 PMID:16166704 gamma-3 proteobacteria ncbi_taxonomy Dintheria GC_ID:1 ncbi_taxonomy Salmonella GC_ID:11 PMID:10319519 PMID:10939679 PMID:12072558 PMID:15653929 PMID:15653930 PMID:3231714 PMID:9731304 Samonella ncbi_taxonomy Salmonella enterica subsp. enterica GC_ID:11 NCBITaxon:149049 PMID:15653929 PMID:15653930 PMID:7149525 Salmonella cholerae-suis subsp. cholerae-suis Salmonella choleraesuis subsp. choleraesuis Salmonella enterica I Salmonella enterica subsp. I ncbi_taxonomy Sedoreovirinae GC_ID:1 ncbi_taxonomy Pasteurellaceae GC_ID:11 PMID:10843050 PMID:15280320 PMID:15388716 PMID:17220461 PMID:2223605 Pasteurellaceae Pohl 1981 ncbi_taxonomy Haemophilus GC_ID:11 Haemophilus Winslow et al. 1917 PMID:1736960 ncbi_taxonomy Haemophilus influenzae Bacterium influenzae Coccobacillus pfeifferi GC_ID:11 Haemophilus meningitidis Influenza-bacillus Mycobacterium influenzae ncbi_taxonomy Burkholderiales 'Burkholderiales' Burkholderia/Oxalobacter/Ralstonia group GC_ID:11 ncbi_taxonomy Corynebacterineae GC_ID:11 NCBITaxon:1761 PMID:11837321 PMID:1736962 PMID:19244447 ncbi_taxonomy Craniata <chordata> Craniata GC_ID:1 ncbi_taxonomy Salmonella enterica subsp. enterica serovar Typhi Bacillus typhi Bacterium (subgen. Eberthella) typhi GC_ID:11 NCBITaxon:41530 NCBITaxon:601 NCBITaxon:72667 PMID:10319519 PMID:10758910 PMID:15653930 PMID:16558776 PMID:9336938 Salmonella choleraesuis serovar Typhi Salmonella choleraesuis typhi Salmonella enterica ser. typhi Salmonella enterica serotype Typhi Salmonella enterica serovar Typhi Salmonella typhi ncbi_taxonomy Bacilli Bacillus/Lactobacillus/Streptococcus group Firmibacteria GC_ID:11 PMID:20212322 ncbi_taxonomy Eutheria GC_ID:1 Placentalia eutherian mammals ncbi_taxonomy placental mammals placentals placentals Homo sapiens GC_ID:1 human man ncbi_taxonomy adverse event Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'. AE YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'. a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events. WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068 The OAE official website is: http://www.oae-ontology.org/. WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm adverse reaction YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device. WEB: http://en.wikipedia.org/wiki/Adverse_event YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention. Yongqun He medical intervention medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. YH WEB: http://wiki.answers.com/Q/What_is_medical_intervention vaccine adverse event an adverse event that occurs after a vaccination. YH musculoskeletal or connective tissue AE an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue. YH, RR, JX WEB: http://www.cdc.gov/niosh/programs/msd/ MedDRA: 10028395 musculoskeletal and connective tissue disorder AE A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture CTCAE: E13872 fatigue AE MedDRA: 10016256 (fatigue); MedDRA: 10024264 (lethargy) NCIt: C3036 lethargy AE HPO: HP_0003388 WEB: http://en.wikipedia.org/wiki/Fatigue_%28medical%29 SIDER: C0015672 CTCAE: E11098 SS, YH a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. contraindication Yongqun He, Sirarat Sarntivijai, Mathias Brochhausen, William Hogan, ‎Philip E. Empey A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment. http://en.wikipedia.org/wiki/Contraindication clinical laboratory test Rebecca Racz, Yongqun He WEB: http://labmed.ascpjournals.org/content/40/2/105.full medical laboratory test a planned process that is specifically a test conducted in a clinical laboratory. cardiac disorder AE HPO: HP_0001627 a cardiovascular disorder AE that has a cardiac disorder outcome. SS, YH MedDRA (SOC) : 10007541 SIDER: C0018799 MedDRA (PT): 10061024 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/heart+disease Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23091623 hair, skin or nail AE YH, SS, JX an adverse event that occurs in hair, skin, or nail. hair, skin, and nail AE hair AE YH, SS a hair, skin, and nail AE that occurs in hair. nail AE a hair, skin, and nail AE that occurs in nail. YH, SS inconsolable crying AE MedDRA: 10065283 a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient YH unusual high-pitched crying AE YH a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient prolonged crying AE a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient YH medical intervention site AE application site reaction MedDRA: 10003055 an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site). YH medical intervention site a site that is used for a medical intervention YH convulsion AE MedDRA ID: 10010904 convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body HPO: HP_0001250 WEB: http://en.wikipedia.org/wiki/Convulsion SIDER: C0009951 SS, YH injection-site induration AE WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site SS, YH injection-site pruritus AE WEB: http://medical-dictionary.thefreedictionary.com/pruritus SS, YH injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection MedDRA: 10022093 WEB: http://en.wikipedia.org/wiki/Itch injection-site rash AE SS, YH WEB: http://en.wikipedia.org/wiki/Rash injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site injection-site warmth AE injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site SS, YH joint swelling AE SIDER: C0152031 SS, YH HPO: HP_0005833 MedDRA ID: 10023232 A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm lymphadenitis AE SS, YH HPO: HP_0002840 SIDER: C0024205 WEB: http://en.wikipedia.org/wiki/Lymphadenopathy A lymphadenopathy AE that results in swollen/enlarged lymph nodes muscular weakness AE HPO: HP_0001324 a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength). MedDRA ID: 10028372 SS, YH SIDER: C0151786 WEB: http://en.wikipedia.org/wiki/Muscular_weakness musculoskeletal stiffness AE SIDER: C0948525 MedDRA ID: 10052904 SS, YH a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton HPO: HP_0003552 nasal congestion AE WEB: http://en.wikipedia.org/wiki/Nasal_congestion nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels SIDER: C0027424 SS, YH MedDRA: 10028735 HPO: HP_0001742 nasopharyngitis AE a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system SIDER: C0027441 SS, YH common cold AE WEB: http://en.wikipedia.org/wiki/Nasopharyngitis a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system HPO: HP_0002087 otitis media AE NCIt: C34885 SIDER: C0029882 SS, YH an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection CTCAE: E11477 WEB: http://en.wikipedia.org/wiki/Otitis_media HPO: HP_0008623 pharyngitis AE SS, YH WEB: http://en.wikipedia.org/wiki/Pharyngitis pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx SIDER: C0031350 NCIt: C26851 CTCAE: E11525 HPO: HP_0100776 MedDRA ID: 10034835 pharyngolaryngeal pain AE a pain AE that shows a pain in sinus and throat SS, YH, MW MedDRA: 10034844 WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/ HPO: HP_0010833 SIDER: C0858635 rhinitis AE runny nose MedDRA: 10028116 WEB: http://en.wikipedia.org/wiki/Rhinitis SIDER: C0035455 WEB: http://medical-dictionary.thefreedictionary.com/rhinitis HPO: HP_0002257 SS, YH rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose rhinorrhea AE SS, YH rhinorrhoea AE WEB: http://en.wikipedia.org/wiki/Rhinorrhoea rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid upper respiratory tract infection AE SS, YH CTCAE: E11604 NCIt: C35650 an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx SIDER: C0041912 URI, URTI HPO: HP_0002788 WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection fever AE YH, SS Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. WEB: http://en.wikipedia.org/wiki/Pyrexia febrile response MedDRA: 10037660 an abnormal body temperature AE which has an outcome of fever MedDRA: 10005911 CTCAE: E11102 body temperature increased AE pyrexia AE NCIt: C3038 Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °F). rash AE YH SIDER: C0015230 URL: http://en.wikipedia.org/wiki/Rash MedDRA: 10037844 Drug-induced rash is the most commonly reported drug reaction. URL: http://www.webmd.com/skin-problems-and-treatments/guide/common-rashes Wick JY. Drug-induced rash: nuisance or threat? Consult Pharm. 2013 Mar;28(3):160-6. PMID: 23462025. a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. HPO: HP_0000988 infection AE YH, JX MedDRA: 10021789 change of name from 'infection adverse event' to 'infectious adverse event' on 09/23/13 for a better clinical relevance, move 'infection adverse event' as an alternative term - SS an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite. infection infectious adverse event WEB: http://medical-dictionary.thefreedictionary.com/infection syndrome AE An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. YH injection-site AE injection site AE YH, JX, SS MDR: 10022095 injection-site AE is an AE that occurs in an injection site (e.g., during vaccination). CTCAE: E11138 NCIt: C3508 injection-site adverse event injection-site reaction local reaction AE injection-site edema AE an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found. injection-site oedema AE YH, RR injection-site swelling AE WEB: http://www.uptodate.com/contents/edema-swelling-beyond-the-basics MedDRA: 10053425 injection-site pain AE a pain AE that occurs in an injection site of a medical intervention MedDRA: 10022086 YH injection-site mass AE YH, SS injection site nodule AE an injection-site AE that display an injection-site mass injection-site mass is a mass at physical injection site pruritus AE NCIt:C3344 SIDER: C0033774 WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity CTCAE:E13686 itching MedDRA:10037087 YH, SS, MW pruritus generalised AE itch Pruritus is an itch (Latin: pruritus), i.e., an unpleasant sensation that evokes the desire or reflex to scratch. HPO: HP_0000989 a skin adverse event that has an outcome of pruritus pain AE CTCAE: E11167 SIDER: C0030193 HPO: HP_0010833 NCIt: C3303 a sensory capability AE that has an outcome of pain in a patient YH myalgia AE SIDER: C0231528 MedDRA:10028411 NCIt:C27009 YH, MW HPO: HP_0003326 muscle pain AE CTCAE:E12485 a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders. urticaria AE SIDER: C0042109 Urticaria AE is a rash AE notable for dark red, raised, itchy bumps. MedDRA:10046735 YH, MW hives CTCAE:E13746 HPO: HP_0001025 NCIt:C3432 headache AE SIDER: C0018681 MedDRA: 10019211 a pain AE that has an outcome of headache HPO: HP_0002315 YH, MW respiratory system AE I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He YH an AE that occurs in respiratory system. abnormal blood pressure AE MP: MP_0000230 a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries asthenia AE HPO: HP_0001324 MedDRA ID: 10003549 YH SIDER: C0004093 a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength. muscle ache AE a muscle pain AE that has an outcome of muscle ache. YH arthralgia AE An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. CTCAE:E12374 NCIt:C50464 SIDER: C0003862 YH, MW HPO: HP_0002829 MedDRA:10003239 dizziness AE HPO: HP_0002321 YH, SS, MW a sensory capability AE that has an outcome of dizziness Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. CTCAE:E12631 NCIt:C37943 MedDRA ID: 10013573 SIDER: C0012833 malaise AE YH HPO: HP_0002321 MDR: 10025482 CTCAE: E11152 NCIt: C3832 Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. SIDER: C0231218 a sensory capability AE that has an outcome of malaise somnolence AE CTCAE:E12814 HPO: HP_0001262 drowsiness a behavior and neurological AE that has an outcome of somnolence MedDRA:10041349 Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). SIDER: C2830004 YH, SS, MW NCIt:C26754 crying abnormal AE MedDRA: 10011469 YH a behavior and neurological AE that has an outcome of abnormal crying in a patient chills AE feeling cold AE MedDRA: 10008531 YH CTCAE: E11074 SIDER: C0085593 Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. HPO: HP_0001945 a sensory capability AE that has an outcome of chills NCIt: C35143 anorexia AE decreased appetite AE YH, MW HPO: HP_0002039 a gustatory system AE which demonstrates a decreased sensation of appetite. MedDRA: 10002649 (anorexia nervosa); MedDRA: 10061428 (decreased appetite); MedDRA: 10002646 (anorexia). WEB: http://www.mayoclinic.org/diseases-conditions/anorexia/basics/definition/con-20033002 anorexia nervosa AE SIDER: C0003123 cough AE WEB: http://medical-dictionary.thefreedictionary.com/cough YH, SS, MW coughing AE cough WEB: http://www.nlm.nih.gov/medlineplus/cough.html an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear CTCAE:E13364 NCIt:C37935 MedDRA:10011224 flu syndrome AE YH NCIt: C78302 CTCAE: E11108 flu-like symptom AE a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention. syncope AE SIDER: C0039070 MedDRA: 10024855 a sensory capability AE that has an outcome of loss of consciousness, fainting WEB: http://en.wikipedia.org/wiki/Unconsciousness fainting Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. MedDRA:10042772 NCIt:C35053 CTCAE:E12832 YH, SS, MW HPO: HP_0001279 WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29 abdominal pain AE WEB: http://en.wikipedia.org/wiki/Abdominal_pain HPO: HP_0002027 SIDER: C0000737 YH, SS According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). a pain AE that is observed in abdominal cavity MedDRA ID: 10000081 hypertension AE MedDRA: 10005750 NCIt:C3117 HPO: HP_0000822 blood pressure increased SIDER: C0020538 CTCAE:E13785 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21722707 YH, SS, MW an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states MedDRA:10020772 MP: MP_0000231 skin nodule AE YH According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). a skin adverse event that has an outcome of skin nodule HPO: HP_0200036 SIDER: C0037287 hemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage haemorrhage AE bleeding AE MP: MP_0001914 a cardiovascular disorder AE that has an outcome of hemorrhage loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels MedDRA: 10055798 lung AE MedDRA: 10025082 YH SIDER: C0024115 lung disorder AE a respiratory system AE which has an outcome of lung disorder HPO: HP_0006552 muscle AE a musculoskeletal system AE that occurs in muscle. YH digestive system AE YH an AE that occurs in digestive system. joint disorder AE a musculoskeletal system AE which has an outcome of joint disorder YH gastrointestinal disorder AE SIDER: C0017178 According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). a digestive system AE which has an outcome of a gastrointestinal disorder YH HPO: HP_0011024 ear AE an AE that occurs in ear. SIDER: C0013447 ear disorder AE YH HPO: HP_0000598 immune system AE According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). HPO: HP_0002715 YH SIDER: C0021053 immune system disorder AE an AE that occurs in immune system. acute brain syndrome AE a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention. YH cardiovascular AE HPO: HP_0001626 SIDER: C0007222 MedDRA ID: 10007649 YH an AE that occurs in cardiovascular system. cardiovascular disorder AE sore throat AE a respiratory system AE which has an outcome of sore throat YH, MW MedDRA: 10041367 skin AE WEB: http://www.thefreedictionary.com/skin+disorder a hair, skin, and nail AE that occurs in skin. YH MedDRA: 10040831 abnormal fluid regulation AE MP: MP_0001784 a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid hypotension AE HPO: HP_0002615 NCIt:C3128 MedDRA: 10005734 YH, MW MedDRA:10021097 CTCAE:E13791 blood pressure decreased, low blood pressure MP: MP_0001596 an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states SIDER: C0020649 abnormal digestion AE MP: MP_0001664 a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy homeostasis AE an AE that occurs in the homeostasis system. anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues MP: MP_0001764 edema AE MP: MP_0001785 WEB: http://en.wikipedia.org/wiki/Oedema MedDRA: 10030095 MedDRA: 10016807 an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues oedema, swelling, dropsy MedDRA: 10042674 WEB: http://en.wikipedia.org/wiki/Swelling_(medical) inflammation AE SIDER: C0021368 SS, YH HPO: HP_0007891 MedDRA: 10061218 WEB: http://en.wikipedia.org/wiki/Inflammation MP: MP_0001846 an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult. respiratory system inflammation AE MP: MP_0002405 an inflammation AE which has an outcome of respiratory system inflammation, the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system vasculitis AE NCIt:C26912 MP: MP_0001864 CTCAE:E13837 YH, MW HPO: HP_0002633 an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel SIDER: C0042384 MedDRA:10047115 It's an inflammation. abnormal respiration AE Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He MP: MP_0001943 According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung gustatory system AE MP: MP_0001985 YH, JX an adverse event that occurs in a gustatory system behavioral and neurological AE WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/ YH, JX any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls behavior AE disruptive behavioral disorder AE MP: MP_0004924 an adverse event that has an outcome of an abnormal behavior and neurological phenotype. behavioral AE behavioral disorder AE movement disorder AE HPO: HP_0100022 SIDER: C0026650 MP: MP_0002066 MedDRA ID: 10028035 a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements sensory capability AE MP: MP_0002067 a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus hypersensitivity AE MedDRA: 10020751 MedDRA ID: 10020751 Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal. JX, LW, YH MP: MP_0002148 HPO: HP_0100326 WEB: http://en.wikipedia.org/wiki/Hypersensitivity hypersensitivity reaction AE 超敏反应 SIDER: C0020517 nausea AE MedDRA: 10028813 MP: MP_0003259; MDR: 10028813 HPO: HP_0002018 MedDRA ID: 10028813 SIDER: C0027497 an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit vomiting AE NCIt: C3442 regurgitation AE MedDRA ID: 10047700 MedDRA: 10047700 SIDER: C0042963 MP: MP_0003260; MDR: 10047700 CTCAE: E11068 HPO: HP_0002013 an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity abnormal defecation AE MP: MP_0003866 a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces diarrhea AE MedDRA: 10012735 diarrhoea AE MP: MP_0005036 WEB: http://medical-dictionary.thefreedictionary.com/diarrhea an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel abnormal body temperature AE MP: MP_0005535 a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being ecchymosis AE MP: MP_0009276 MedDRA ID: 10014080 HPO: HP_0000978 a hemorrhage AE that has an outcome of ecchymosis SIDER: C0013491 an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis low-grade fever AE WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 The low-grade level of fever is beneficial. With most microbes/"bugs" that a child will be exposed to, this fever will assist the body in repelling the invader. YH low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C). musculoskeletal pain AE MedDRA ID: 10028391 Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones. WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain a pain AE that has an outcome of musculoskeletal pain HPO: HP_0003326 SS, YH SIDER: C0026858 injection-site erythema AE SS, YH MedDRA: 10022061 injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection WEB: http://en.wikipedia.org/wiki/Erythema WEB: http://medical-dictionary.thefreedictionary.com/erythema erythema AE reddish skin SIDER: C0041834 MedDRA ID: 10015150 Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin. MP:0001190 WEB: http://en.wikipedia.org/wiki/Erythema HPO: HP_0010783 MedDRA: 10015150 SS, YH hematoma AE NCIt: C37921 SS, YH MedDRA ID: 10018852; MedDRA ID: 10019428 CTCAE: E11666 an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. SIDER: C0018944 YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma". WEB: http://en.wikipedia.org/wiki/Hematoma HPO: HP_0001892 ecchymoses AE bruise AE haematoma AE vasodilatation AE a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. WEB: http://en.wikipedia.org/wiki/Vasodilation SS, YH HPO: HP_0004927 SIDER: C0595862 bronchospasm AE HPO: HP_0002099 SIDER: C0006266 CTCAE:E13352 DJ, SS, YH, MW a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles MedDRA:10006482 WEB: http://medical-dictionary.thefreedictionary.com/bronchospasm NCIt:C34439 cardiac failure AE DJ, SS, YH heart failure NCIt: C50577 a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body WEB: http://medical-dictionary.thefreedictionary.com/cardiac+failure SIDER: C0018801 MedDRA: 10007554 HPO: HP_0001635 CTCAE: E10124 cardiomyopathy AE WEB: https://en.wikipedia.org/wiki/Cardiomyopathy DJ, SS, YH a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure SIDER: C0878544 HPO: HP_0001638 MedDRA: 10007636 WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy irritability AE SZ, DJ, SS, YH SIDER: C0022107 MedDRA: 10022998 HPO: HP_0000737 Behavior and Neurological AE that results in the patient being easily annoyed/irritated NCIt: C50623 CTCAE: E11144 feverish (subjective) AE localized edema AE SIDER: C0013609 CTCAE: E11148 NCIt: C78437 HPO: HP_0000969 SZ, DJ, SS, YH localised oedema AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115975/ an edema AE occuring in a specific region MedDRA: 10048961 localised edema AE lymphadenopathy AE HPO: HP_0002716 SIDER: C0497156 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/lymphadenopathy an immune system disorder AE that has an outcome of lymphadenopathy, which is a term meaning "disease of the lymph nodes" . It is generally a disease or inflammation of the lymph nodes, could be due to infection, auto-immune disease or malignancy MedDRA: 10025197 sleep disorder AE SIDER: C0851578 MedDRA: 10040984 a behavior and neurological AE that results in irregular sleep patterns SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sleep+disorder HPO: HP_0002360 injection-site redness AE YH an injection-site AE that display an redness in the injection-site injection-site tenderness AE MedDRA: 10043224 a sensory capability AE that shows up skin tenderness and occurs in an injection site of a medical intervention YH arm motion limitation AE YH a movement disorder AE that has an outcome of arm motion limitation injection-site muscular soreness AE a sensory capability AE that shows up muscular soreness at the injection site of a medical intervention MedDRA: 10028332 YH sleepiness AE YH a sleep disorder AE that shows up sleepiness (Sluggish from sleep, inactive, quiet). MedDRA: 10041014 mild hypersensitivity AE YH a hypersensitivity AE that is mild. injection-site arm edema AE an injection-site edema AE that occurs in the arm. YH restlessness AE a psychiatric disorder AE that shows restlessness NCIt:C74533 YH, MW UMLS_CUI: C0085631 MedDRA:10038743 CTCAE:E12960 WEB: http://dictionary.reference.com/browse/restlessness induration with tenderness AE a sensory capability AE that results in a sensation of induration with tenderness. YH fussiness AE YH a sensory capability AE that results in a sensation of fussiness decreased sleep AE YH a sleep disorder AE that shows decreased sleep increased sleep AE a sleep disorder AE that shows increased sleep YH joint pain AE YH a pain AE that occurs at a joint tiredness AE This term appears to be a synonym to the 'fatigue AE'. Tiredness AE is a sensory capability AE that results in a sensation of tiredness. hypodynamia AE 疲劳/乏力 MedDRA: 10043890 JX, LW, YH severity of adverse event AE severity YH, SS a process quality that represents the level of severity of an adverse event. psychiatric disorder AE WEB: http://en.wikipedia.org/wiki/Mental_disorder a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative. MedDRA ID: 10037175 YH, Izabela Birsanescu mental disorder AE AE severity G1 AE severity Grade 1 CTCAE4: E10005 (Grade 1 Adverse Event) YH, SS a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated. Note the AE severity Grade 1 equals to CTCAE G1 AE severity. Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event AE severity G2 a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances). Note the AE severity Grade 2 equals to CTCAE G2 AE severity. Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event YH, SS CTCAE4: E10006 (Grade 2 Adverse Event) AE severity Grade 2 AE severity G3 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event AE severity Grade 3 YH, SS CTCAE4: E10007 (Grade 3 Adverse Event) Note the AE severity Grade 3 equals to CTCAE G3 AE severity. a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). AE severity G4 AE severity Grade 4 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral). Note the AE severity Grade 4 equals to CTCAE G4 AE severity. CTCAE4: E10008 (Grade 4 Adverse Event) YH, SS AE severity G5 Note the AE severity Grade 5 equals to CTCAE G5 AE severity. YH, SS AE severity Grade 5 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event CTCAE4: E10009 (Grade 5 Adverse Event) a severity of AE that results in death. local AE an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation. YH, JX URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction behavior abnormal quality YH, JX a behavioral quality where the behavior in an organism is abnormal. WEB: https://en.wikipedia.org/wiki/Abnormality_(behavior) planned process 'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.) 6/11/9: Edited at workshop. Used to include: is initiated by an agent Bjoern Peters Injecting mice with a vaccine in order to test its efficacy branch derived A processual entity that realizes a plan which is the concretization of a plan specification. This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call) planned process processed material Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples Is a material entity that is created or changed during material processing. PERSON: Alan Ruttenberg processed material organization GROUP: OBI PERSON: Alan Ruttenberg PERSON: Bjoern Peters PERSON: Philippe Rocca-Serra PERSON: Susanna Sansone An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods. organization material to be added role 9 March 09 from discussion with PA branch OBI Role Branch drug added to a buffer contained in a tube; substance injected into an animal; material to be added role material to be added role is a protocol participant role realized by a material which is added into a material bearing the target of material addition role in a material addition process target of material addition role From Branch discussion with BP, AR, MC -- there is a need for the recipient to interact with the administered material. for example, a tooth receiving a filling was not considered to be a target role. GROUP: Role Branch OBI peritoneum of an animal receiving an interperitoneal injection; solution in a tube receiving additional material; location of absorbed material following a dermal application. target of material addition role is a role realized by an entity into which a material is added in a material addition process target of material addition role host role 30 Mar09 submitted by vaccine community 30Mar09 virus reproducing inside a cell; bacteria causing a disease, host can be harmed or not. we want to avoid a cat sitting on my lap and an animal care technician; these are not examples or hosts; dental cares = on tooth, but part of outer layer of tooth, so covered by "within" in the definition GROUP: Role Branch In biology, a host is an organism that harbors a virus or parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter. http://en.wikipedia.org/wiki/Host_(biology) 30 March 09 OBI host role host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role http://en.wikipedia.org/wiki/Host_(biology) organism 10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms') GROUP: OBI Biomaterial Branch A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. WEB: http://en.wikipedia.org/wiki/Organism animal fungus organism plant virus administering substance in vivo 2009-11-10. Tracker: https://sourceforge.net/tracker/?func=detail&aid=2893050&group_id=177891&atid=886178 A process by which a substance is intentionally given to an organism resulting in exposure of the organism to that substance. Balb/c mice received an intracameral or subconjunctival injection of trinitrophenylated spleen cells Person:Bjoern Peters Bjoern Peters Different routes and means of administration should go as children underneath this IEDB administering substance in vivo injecting mice with 10 ug morphine intranasally, a patient taking two pills of 1 mg aspirin orally needs roles such as perturber and perturbee (children of input role). Perturb is too strong. Host might be the name for one role. Others considered: Doner, Donated, Acceptor. genome Book: Eugene Nester, Denise Anderson, C. Evans Roberts, Jr., Microbiology (Companion Site): A Human Perspective, 7th Edition. Mcgraw Hill, October 18, 2011. ISBN-13: 978-0073375311 A genome is a material entity that represents the entirety of an organism's hereditary information. The genome includes both the genes and the non-coding sequences of the DNA and RNA. Oliver He WEB: http://en.wikipedia.org/wiki/Genome gene A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule. Oliver He WEB: http://www.ncbi.nlm.nih.gov/books/NBK21640/ In addition to the coding regions (exons), a gene includes transcription-control regions and sometimes introns. Although the majority of genes encode proteins, some encode tRNAs, rRNAs, and other types of RNA. genome of Bacteria 2 The genome of an organism of Bacteria Yue Liu, Bin Zhao, Oliver He genome of Proteobacteria 1224 The genome of an organism of Proteobacteria Yue Liu, Bin Zhao, Oliver He gene of Bacteria 2 A gene of an organism of Bacteria Yue Liu, Bin Zhao, Oliver He gene of Proteobacteria 1224 A gene of an organism of Proteobacteria Yue Liu, Bin Zhao, Oliver He bodily process Albert Goldfain creation date: 2009-06-23T11:53:49Z pathological bodily process Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf A bodily process that is clinically abnormal. creation date: 2009-06-23T11:54:29Z bacterial vaccine adverse event a vaccine adverse event that is associated with administration of a bacterial vaccine Yongqun He virus vaccine adverse event Yongqun He a vaccine adverse event that is associated with administration of a virus vaccine parasite vaccine adverse event Yongqun He a vaccine adverse event that is associated with administration of a parasite vaccine fugal vaccine adverse event Yongqun He a vaccine adverse event that is associated with administration of a fungal vaccine cancer vaccine adverse event a vaccine adverse event that is associated with administration of a cancer vaccine Yongqun He bacterial and viral combination vaccine adverse event Yongqun He a vaccine adverse event that is associated with administration of a bacterial and viral combination vaccine adverse event associated with Diphtheria & Tetanus Toxoids Absorbed Yongqun He, Erica Marcos Engerix-B vaccine adverse event Yongqun He, Erica Marcos Flublok vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Flublok. Yongqun He, Erica Marcos Fluarix vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Fluarix. Yongqun He, Erica Marcos Fluarix Quadrivalent vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Fluarix Quadrivalent vaccine. Yongqun He, Erica Marcos Flucelvax vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Flucelvax. Yongqun He, Erica Marcos Flulaval vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Flulaval. Yongqun He, Erica Marcos FluMist Quadrivalent vaccine adverse event Yongqun He, Erica Marcos An influenza vaccine adverse event that is associated with the administration of FluMist Quadrivalent vaccine. Fluvirin vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Fluvirin. Yongqun He, Erica Marcos Fluzone vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Fluzone. Yongqun He, Erica Marcos Fluzone High-Dose vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Fluzone High-dose vaccine. Yongqun He, Erica Marcos Fluzone Intradermal vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Fluzone intradermal vaccine. Yongqun He, Erica Marcos Gardasil vaccine adverse event Yongqun He, Erica Marcos Havrix vaccine adverse event Yongqun He, Erica Marcos Hiberix vaccine adverse event Yongqun He, Erica Marcos Imovax Rabies vaccine adverse event Yongqun He, Erica Marcos Infanrix vaccine adverse event Yongqun He, Erica Marcos Influenza Virus Vaccine H5N1 vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Influenza virus vaccine H5N1 vaccine. Yongqun He, Erica Marcos IPOL vaccine adverse event Yongqun He, Erica Marcos Ixiaro vaccine adverse event Yongqun He, Erica Marcos JE-Vax vaccine adverse event Yongqun He, Erica Marcos Kinrix vaccine adverse event Yongqun He, Erica Marcos Menactra vaccine adverse event Yongqun He, Erica Marcos MenHibrix vaccine adverse event Yongqun He, Erica Marcos Menomune-A/C/Y/W-135 vaccine adverse event Yongqun He, Erica Marcos Menveo vaccine adverse event Yongqun He, Erica Marcos Meruvax II vaccine adverse event Yongqun He, Erica Marcos Pediarix vaccine adverse event Yongqun He, Erica Marcos PedvaxHIB vaccine adverse event Yongqun He, Erica Marcos Pentacel vaccine adverse event Yongqun He, Erica Marcos Pneumovax 23 vaccine adverse event Yongqun He, Erica Marcos Prevnar vaccine adverse event Yongqun He, Erica Marcos Prevnar 13 vaccine adverse event Yongqun He, Erica Marcos ProQuad vaccine adverse event Yongqun He, Erica Marcos RabAvert vaccine adverse event Yongqun He, Erica Marcos Recombivax HB vaccine adverse event Yongqun He, Erica Marcos Rotarix vaccine adverse event Yongqun He, Erica Marcos RotaTeq vaccine adverse event Yongqun He, Erica Marcos Tenivac vaccine adverse event Yongqun He, Erica Marcos adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological Yongqun He, Erica Marcos Tetanus Toxoid (boost only) vaccine adverse event Yongqun He Tetanus Toxoid Absorbed vaccine adverse event Yongqun He, Erica Marcos Tripedia vaccine adverse event Yongqun He, Erica Marcos Twinrix vaccine adverse event Yongqun He, Erica Marcos Typhim Vi vaccine adverse event Yongqun He, Erica Marcos Vaqta vaccine adverse event Yongqun He, Erica Marcos Varivax vaccine adverse event Yongqun He, Erica Marcos Vivotif vaccine adverse event Yongqun He, Erica Marcos YF-Vax vaccine adverse event Yongqun He, Erica Marcos Zostavax vaccine adverse event Yongqun He, Erica Marcos Agriflu vaccine adverse event Yongqun He, Erica Marcos An influenza vaccine adverse event that is associated with the administration of Agriflu. Biothrax vaccine adverse event Yongqun He, Erica Marcos Flublok-associated muscle pain AE 0.11 50 64 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a muscle pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Yongqun He, Jiangan Xie Boostrix vaccine adverse event Yongqun He, Erica Marcos Cervarix vaccine adverse event Yongqun He, Erica Marcos Comvax vaccine adverse event Yongqun He, Erica Marcos Daptacel vaccine adverse event Yongqun He, Erica Marcos Decavac vaccine adverse event Yongqun He, Erica Marcos influenza vaccine adverse event Yongqun He a virus vaccine adverse event that is associated with administration of an influenza virus vaccine Haemophilus vaccine adverse event a bacterial adverse event that is associated with administration of a Haemophilus vaccine Yongqun He adenovirus vaccine adverse event Yongqun He a virus vaccine adverse event that is associated with administration of an adenovirus vaccine adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral an adenovirus vaccine adverse event that is associated with administration of an adenovirus vaccine Adenovirus Type 4 and Type 7 Vaccine, Live, Oral Yongqun He human papillomavirus vaccine adverse event a virus vaccine adverse event that is associated with administration of a human papillomavirus vaccine Yongqun He Bacillus anthracis vaccine adverse event a bacterial adverse event that is associated with administration of a Bacillus anthracis vaccine Yongqun He Streptococcus pneumoniae vaccine adverse event Yongqun He, Erica Marcos Neisseria meningitidis vaccine adverse event Yongqun He, Erica Marcos diphtheria vaccine adverse event Yongqun He a bacterial vaccine adverse event that is associated with administration of diphtheria vaccine Diphtheria-Tetanus vaccine adverse event Yongqun He a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus vaccine Diphtheria-Tetanus-Pertussis vaccine adverse event Yongqun He a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis vaccine Diphtheria-Tetanus-Poliovirus vaccine adverse event a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Poliovirus vaccine Yongqun He Diphtheria-Tetanus-Pertussis-Poliovirus vaccine adverse event Yongqun He a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus vaccine Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine adverse event a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine Yongqun He Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine adverse event Yongqun He a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine Salmonella vaccine adverse event Yongqun He a bacterial vaccine adverse event that is associated with administration of Salmonella vaccine Haemophilus b and Hepatitis B vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Haemophilus b and Hepatitis B vaccine Hepatitis A virus vaccine adverse event a viral vaccine adverse event that is associated with administration of Hepatitis A virus vaccine Yongqun He Hepatitis A&B vaccine adverse event a viral vaccine adverse event that is associated with administration of Hepatitis A&B vaccine Yongqun He Hepatitis B virus vaccine adverse event a viral vaccine adverse event that is associated with administration of Hepatitis B virus vaccine Yongqun He Herpesvirus vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Herpesvirus vaccine Japanese encephalitis virus vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Japanese encephalitis virus vaccine Measles virus vaccine adverse event a viral vaccine adverse event that is associated with administration of Measles virus vaccine Yongqun He Measles-Mumps-Rubella-Vericella vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Measles-Mumps-Rubella-Vericella vaccine Poliovirus vaccine adverse event a viral vaccine adverse event that is associated with administration of Poliovirus vaccine Yongqun He smallpox vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of smallpox vaccine Rabies vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Rabies vaccine Rotavirus vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Rotavirus vaccine Rubella vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Rubella vaccine Yellow fever vaccine adverse event Yongqun He a viral vaccine adverse event that is associated with administration of Yellow fever vaccine Afluria-associated injection-site pain AE 0.1 65 0.4 18 64 0.6 17 5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Yongqun He, Erica Marcos A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site pain AE Afluria-associated injection-site redness AE 0.2 17 5 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site redness AE Afluria-associated local swelling AE 0.1 17 5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an local swelling AE Yongqun He, Erica Marcos Afluria-associated headache AE 0.2 18 64 0.2 17 5 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated myalgia AE 0.2 17 5 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Yongqun He, Erica Marcos Afluria-associated malaise AE 0.1 17 5 0.2 18 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Yongqun He, Erica Marcos A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an malaise AE Afluria-associated fever AE 0.1 17 5 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated injection-site tenderness AE 0.3 65 0.6 18 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Yongqun He, Erica Marcos A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site tenderness AE Afluria-associated muscle ache AE 0.2 18 64 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an muscle ache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Yongqun He, Erica Marcos Agriflu-associated injection-site pain AE 0.1 18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an injection-site pain AE Agriflu-associated headache AE 0.1 18 A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf Yongqun He, Erica Marcos Agriflu-associated myalgia AE 0.1 18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an myalgia AE Agriflu-associated malaise AE 0.1 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an malaise AE Yongqun He, Erica Marcos Flulaval-associated injection-site pain AE 18 0.51 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an injection-site pain AE Flulaval-associated injection-site redness AE 18 0.13 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an injection-site redness AE Flulaval-associated local swelling AE 18 0.11 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an local swelling AE Yongqun He, Erica Marcos Flulaval-associated fatigue AE 18 0.2 Yongqun He, Erica Marcos A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an fatigue AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated headache AE 18 0.18 A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated myalgia AE 18 0.18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Yongqun He, Erica Marcos A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an myalgia AE Fluarix-associated drowsiness 5 3 0.17 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an drowsiness Yongqun He, Erica Marcos Fluarix-associated irritability AE 5 3 0.17 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated decreased appetite AE 5 3 0.16 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Yongqun He, Erica Marcos A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an decreased appetite AE Fluarix-associated arthralgia AE 6 7 0.1 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated gastrointestinal disorder AE 6 7 0.1 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an gastrointestinal disorder AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated injection-site redness AE 17 3 0.23 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Yongqun He, Erica Marcos A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an injection-site redness AE Fluarix-associated local swelling AE 17 3 0.19 Yongqun He, Erica Marcos A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated injection-site pain AE 18 0.36 17 3 0.44 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an injection-site pain AE Yongqun He, Erica Marcos Fluarix-associated muscle ache AE 18 0.16 6 7 0.18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an muscle ache AE Fluarix-associated headache AE 18 0.16 6 7 0.16 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Yongqun He, Erica Marcos Fluarix-associated fatigue AE 18 0.16 6 7 0.2 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Flublok-associated injection-site pain AE 0.19 65 0.32 50 64 0.37 49 18 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Yongqun He, Erica Marcos Flublok-associated headache AE 0.10 65 0.15 49 18 0.15 50 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Yongqun He, Erica Marcos A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a headache AE Flublok-associated fatigue AE 0.13 50 64 0.13 65 0.15 49 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Yongqun He, Erica Marcos, Jiangan Xie A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a fatigue AE Flublok-associated myalgia AE 0.11 49 18 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Flucelvax-associated injection-site pain AE 18 64 0.28 Yongqun He, Erica Marcos A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Flucelvax-associated myalgia AE 18 64 0.11 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Yongqun He, Erica Marcos A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an myalgia AE Flucelvax-associated injection-site erythema AE 18 64 0.13 65 0.1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Yongqun He, Erica Marcos A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an injection-site erythema AE Flucelvax-associated fatigue AE 18 64 0.12 65 0.11 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an fatigue AE Flucelvax-associated headache AE 18 64 0.16 65 0.1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Yongqun He, Erica Marcos A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an headache AE Flucelvax-associated malaise AE 18 0.1 A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Fluvirin-associated mild hypersensitity AE Yongqun He, Erica Marcos A Fluvirin vaccine adverse event that is associated with an administration of Fluvirin and displays an mild hypersensitity AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123694.pdf Fluvirin-associated flu-like syndrome AE 4 A Fluvirin vaccine adverse event that is associated with an administration of Fluvirin and displays an flu-like syndrome AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123694.pdf Yongqun He, Erica Marcos Fluzone-associated injection-site tenderness AE 0.5 8 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Yongqun He, Erica Marcos A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site tenderness AE Fluzone-associated injection-site redness AE 0.25 8 0.5 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated irritability AE 0.25 2.9 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Yongqun He, Erica Marcos A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an irritability AE Fluzone-associated drowsiness 0.25 2.9 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an drowsiness Yongqun He, Erica Marcos Fluzone-associated myalgia AE 0.2 8 3 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE Fluzone-associated injection-site pain AE 0.5 18 64 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated headache AE 0.3 18 64 Yongqun He, Erica Marcos A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated myalgia AE 0.3 18 64 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE Fluzone-associated injection-site pain AE 0.2 65 Yongqun He, Erica Marcos A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated headache AE 0.1 65 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Yongqun He, Erica Marcos Fluzone-associated myalgia AE 0.1 65 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Yongqun He, Erica Marcos Fluzone-associated malaise AE 0.1 65 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an malaise AE Yongqun He, Erica Marcos Fluzone High-Dose-associated injection-site pain AE 0.3 65 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an injection-site pain AE Yongqun He, Erica Marcos Fluzone High-Dose-associated headache AE 0.1 65 Yongqun He, Erica Marcos A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Fluzone High-Dose-associated myalgia AE 0.1 65 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Yongqun He, Erica Marcos A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an myalgia AE Fluzone High-Dose-associated erythema AE 0.1 65 Yongqun He, Erica Marcos A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Fluzone High-Dose-associated malaise AE 0.1 65 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Yongqun He, Erica Marcos A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an malaise AE Fluzone Intradermal-associated injection-site erythema AE 0.75 18 64 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated injection-site induration AE 0.5 18 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Yongqun He, Erica Marcos A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site induration AE Fluzone Intradermal-associated local swelling AE 0.5 18 64 Yongqun He, Erica Marcos A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated injection-site pain AE 0.5 18 64 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Yongqun He, Erica Marcos Fluzone Intradermal-associated OAE_0000373 0.4 18 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an OAE_0000373 Yongqun He, Erica Marcos Fluzone Intradermal-associated headache AE 0.2 18 64 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an headache AE Fluzone Intradermal-associated myalgia AE 0.2 18 64 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Yongqun He, Erica Marcos Fluzone Intradermal-associated malaise AE 0.2 18 64 Yongqun He, Erica Marcos A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an malaise AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf FluMist-associated fever AE 0.1 6 2 A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf Yongqun He, Erica Marcos FluMist-associated nasal congestion AE 0.1 49 2 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf Yongqun He, Erica Marcos A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an nasal congestion AE FluMist-associated sore throat AE 0.1 49 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf Yongqun He, Erica Marcos A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an sore throat AE FluMist Quadrivalent-associated nasal congestion AE 49 18 0.44 17 2 0.32 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM294307.pdf Yongqun He, Erica Marcos A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an nasal congestion AE FluMist Quadrivalent-associated fever AE 17 2 0.07 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM294307.pdf Yongqun He, Erica Marcos FluMist Quadrivalent-associated sore throat AE 49 18 0.19 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an sore throat AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM294307.pdf Yongqun He, Erica Marcos Fluarix Quadrivalent-associated injection-site pain AE 18 0.36 17 3 0.44 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Yongqun He, Erica Marcos Fluarix Quadrivalent-associated injection-site redness AE 17 3 0.23 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Yongqun He, Erica Marcos Fluarix Quadrivalent-associated local swelling AE 17 3 0.19 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an local swelling AE Fluarix Quadrivalent-associated drowsiness 5 3 0.17 Yongqun He, Erica Marcos A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an drowsiness WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated irritability AE 5 3 0.17 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an irritability AE Yongqun He, Erica Marcos Fluarix Quadrivalent-associated decreased appetite AE 5 3 0.16 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Yongqun He, Erica Marcos A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an decreased appetite AE Fluarix Quadrivalent-associated fatigue AE 18 0.16 17 6 0.2 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated muscle ache AE 18 0.16 17 6 0.18 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an muscle ache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated headache AE 6 0.16 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an headache AE Yongqun He, Erica Marcos Fluarix Quadrivalent-associated arthralgia AE 17 6 0.1 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an arthralgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Yongqun He, Erica Marcos Fluarix Quadrivalent-associated gastrointestinal disorder AE A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an gastrointestinal disorder AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Influenza Virus Vaccine H5N1-associated injection-site pain AE 18 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf Yongqun He, Erica Marcos A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an injection-site pain AE Influenza Virus Vaccine H5N1-associated headache AE 18 64 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an headache AE Influenza Virus Vaccine H5N1-associated malaise AE 18 64 Yongqun He, Erica Marcos A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an malaise AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf Influenza Virus Vaccine H5N1-associated myalgia AE 18 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf Yongqun He, Erica Marcos A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an myalgia AE Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated upper respiratory tract infection AE 0.05 50 17 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an upper respiratory tract infection AE Yongqun He, Erica Marcos Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated headache AE 0.05 50 17 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an headache AE Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated nasal congestion AE 0.05 50 17 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Yongqun He, Erica Marcos A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an nasal congestion AE Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated pharyngolaryngeal pain AE 0.05 50 17 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an pharyngolaryngeal pain AE Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated cough 0.05 50 17 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an cough WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Yongqun He, Erica Marcos Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated arthralgia AE 0.05 50 17 Yongqun He, Erica Marcos A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an arthralgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated nausea AE 0.05 50 17 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated abdominal pain AE 0.05 50 17 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an abdominal pain AE Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated diarrhea AE 0.05 50 17 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an diarrhea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Yongqun He, Erica Marcos Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated vomiting AE 0.05 50 17 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Yongqun He, Erica Marcos A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an vomiting AE Biothrax-associated injection-site tenderness AE 0.1 65 18 Yongqun He, Erica Marcos A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site tenderness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated injection-site pain AE 0.1 65 18 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated injection-site erythema AE 0.1 65 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site erythema AE Yongqun He, Erica Marcos Biothrax-associated injection-site edema AE 0.1 65 18 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated arm motion limitation AE 0.1 65 18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an arm motion limitation AE Biothrax-associated muscle ache AE 0.05 65 18 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an muscle ache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Yongqun He, Erica Marcos Biothrax-associated fatigue AE 0.05 65 18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an fatigue AE Biothrax-associated headache AE 0.05 65 18 Yongqun He, Erica Marcos A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site redness AE 6 0 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site redness AE Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site warmth AE 6 0 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site warmth AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site edema AE 6 0 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site edema AE Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site induration AE 6 0 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site induration AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated local swelling AE 6 0 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated urticaria AE 6 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an urticaria AE Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site rash AE 6 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site rash AE Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated malaise AE 6 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an malaise AE Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated fever AE 6 0 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated pain AE 6 0 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated hypotension AE 6 0 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an hypotension AE Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated nausea AE 6 0 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated arthralgia AE 6 0 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an arthralgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Yongqun He, Erica Marcos Tripedia-associated injection-site redness AE 0.17 6 0.1896 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Yongqun He, Erica Marcos A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an injection-site redness AE Tripedia-associated local swelling AE 0.17 6 0.1428 Yongqun He, Erica Marcos A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated injection-site pain AE 0.17 6 0.065 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an injection-site pain AE Yongqun He, Erica Marcos Tripedia-associated fever AE 0.17 6 0.0264 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Yongqun He, Erica Marcos Tripedia-associated anorexia AE 0.17 6 0.0724 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Yongqun He, Erica Marcos A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an anorexia AE Tripedia-associated vomiting AE 0.17 6 0.0228 Yongqun He, Erica Marcos A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an vomiting AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated drowsiness 0.17 6 0.1262 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an drowsiness WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Yongqun He, Erica Marcos Tripedia-associated irritability AE 0.17 6 0.0536 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an irritability AE Yongqun He, Erica Marcos Infanrix-associated injection-site pain AE 0.1 0.53 6 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an injection-site pain AE Yongqun He, Erica Marcos Infanrix-associated injection-site redness AE 0.1 0.53 6 0.115 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an injection-site redness AE Infanrix-associated local swelling AE 0.1 0.53 6 0.115 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated fever AE 0.2 0.3 6 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Yongqun He, Erica Marcos A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an fever AE Infanrix-associated drowsiness 0.15 0.6 6 0.115 Yongqun He, Erica Marcos A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an drowsiness WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated irritability AE 0.15 0.6 6 0.115 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated decreased appetite AE 0.15 0.6 6 0.115 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an decreased appetite AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Yongqun He, Erica Marcos Daptacel-associated injection-site tenderness AE 0.3 6 0.115 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site tenderness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Yongqun He, Erica Marcos Daptacel-associated injection-site redness AE 0.3 6 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Yongqun He, Erica Marcos A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site redness AE Daptacel-associated injection-site edema AE 0.3 6 0.115 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated irritability AE 0.5 6 0.115 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an irritability AE Daptacel-associated inconsolable crying AE 0.5 6 0.115 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an inconsolable crying AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Yongqun He, Erica Marcos Daptacel-associated lethargy AE 0.5 6 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Yongqun He, Erica Marcos A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an lethargy AE Daptacel-associated fever AE 0.06 0.16 6 0.115 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Pediarix-associated injection-site pain AE 0.25 6 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Yongqun He, Erica Marcos A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an injection-site pain AE Pediarix-associated injection-site redness AE 0.25 6 0.115 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Yongqun He, Erica Marcos Pediarix-associated local swelling AE 0.25 6 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Yongqun He, Erica Marcos A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an local swelling AE Pediarix-associated fever AE 0.25 6 0.115 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Yongqun He, Erica Marcos Pediarix-associated drowsiness 0.25 6 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an drowsiness Yongqun He, Erica Marcos Pediarix-associated irritability AE 0.25 6 0.115 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an irritability AE Pediarix-associated decreased appetite AE 0.25 6 0.115 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Kinrix-associated injection-site pain AE 0.5 6 4 Yongqun He, Erica Marcos A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated injection-site redness AE 0.25 6 4 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site redness AE Yongqun He, Erica Marcos Kinrix-associated injection-site edema AE 0.25 6 4 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Yongqun He, Erica Marcos A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site edema AE Kinrix-associated local swelling AE 0.25 6 4 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Yongqun He, Erica Marcos Kinrix-associated drowsiness 0.15 6 4 Yongqun He, Erica Marcos A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an drowsiness WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated fever AE 0.15 6 4 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Yongqun He, Erica Marcos Kinrix-associated decreased appetite AE 0.15 6 4 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an decreased appetite AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Yongqun He, Erica Marcos Pentacel-associated irritability AE 0.5 4 0.115 A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Pentacel-associated inconsolable crying AE 0.5 4 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Yongqun He, Erica Marcos A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an inconsolable crying AE Pentacel-associated fever AE 0.06 0.16 4 0.115 Yongqun He, Erica Marcos A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Pentacel-associated injection-site tenderness AE 0.3 4 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Yongqun He, Erica Marcos A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an injection-site tenderness AE Pentacel-associated injection-site edema AE 0.3 4 0.115 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an injection-site edema AE ActHIB-associated injection-site pain AE 1.25 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an injection-site pain AE Yongqun He, Erica Marcos ActHIB-associated injection-site redness AE 1.25 1 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an injection-site redness AE ActHIB-associated local swelling AE 1.25 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf Yongqun He, Erica Marcos A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an local swelling AE ActHIB-associated fever AE 1.25 1 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated irritability AE 1.25 1 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated lethargy AE 1.25 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf Yongqun He, Erica Marcos A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an lethargy AE Hiberix-associated injection-site pain AE 0.2 4 1.25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Yongqun He, Erica Marcos A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an injection-site pain AE Hiberix-associated injection-site redness AE 0.2 4 1.25 Yongqun He, Erica Marcos A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated fever AE 0.2 4 1.25 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an fever AE Hiberix-associated fussiness AE 0.2 4 1.25 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an fussiness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Yongqun He, Erica Marcos Hiberix-associated decreased appetite AE 0.2 4 1.25 Yongqun He, Erica Marcos A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an decreased appetite AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated restlessness AE 0.2 4 1.25 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an restlessness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Yongqun He, Erica Marcos PedvaxHIB-associated irritability AE 0.01 0.17 0.5 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an irritability AE PedvaxHIB-associated sleepiness AE 0.01 0.17 0.5 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an sleepiness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf Yongqun He, Erica Marcos PedvaxHIB-associated injection-site pain AE 0.01 0.17 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site pain AE Yongqun He, Erica Marcos PedvaxHIB-associated injection-site erythema AE 0.01 0.17 0.5 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf Yongqun He, Erica Marcos PedvaxHIB-associated local swelling AE 0.01 0.17 0.5 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated injection-site induration AE 0.01 0.17 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site induration AE Yongqun He, Erica Marcos PedvaxHIB-associated unusual high-patched crying AE 0.01 0.17 0.5 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an unusual high-patched crying AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated prolonged crying AE 0.01 0.17 0.5 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an prolonged crying AE PedvaxHIB-associated diarrhea AE 0.01 0.17 0.5 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an diarrhea AE PedvaxHIB-associated vomiting AE 0.01 0.17 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an vomiting AE Yongqun He, Erica Marcos PedvaxHIB-associated crying abnormal AE 0.01 0.17 0.5 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an crying abnormal AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf Yongqun He, Erica Marcos PedvaxHIB-associated pain AE 0.01 0.17 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an pain AE Yongqun He, Erica Marcos PedvaxHIB-associated otitis media AE 0.01 0.17 0.5 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an otitis media AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf Yongqun He, Erica Marcos PedvaxHIB-associated rash AE 0.01 0.17 0.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf Yongqun He, Erica Marcos A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an rash AE PedvaxHIB-associated upper respiratory tract infection AE 0.01 0.17 0.5 Yongqun He, Erica Marcos A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an upper respiratory tract infection AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf Comvax-associated injection-site pain AE 0.01 1.25 0.115 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Yongqun He, Erica Marcos Comvax-associated injection-site tenderness AE 0.01 1.25 0.115 Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site tenderness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated injection-site soreness AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site soreness AE Comvax-associated local swelling AE 0.01 1.25 0.115 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated injection-site induration AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site induration AE Yongqun He, Erica Marcos Comvax-associated injection-site erythema AE 0.01 1.25 0.115 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site erythema AE Comvax-associated fever AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an fever AE Yongqun He, Erica Marcos Comvax-associated anorexia AE 0.01 1.25 0.115 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an anorexia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated diarrhea AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an diarrhea AE Yongqun He, Erica Marcos Comvax-associated vomiting AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an vomiting AE Comvax-associated irritability AE 0.01 1.25 0.115 Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an irritability AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated somnolence AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an somnolence AE Comvax-associated crying abnormal AE 0.01 1.25 0.115 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an crying abnormal AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated upper respiratory tract infection AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an upper respiratory tract infection AE Comvax-associated rhinorrhea AE 0.01 1.25 0.115 Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rhinorrhea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated cough 0.01 1.25 0.115 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an cough WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Yongqun He, Erica Marcos Comvax-associated rhinitis AE 0.01 1.25 0.115 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rhinitis AE Comvax-associated rash AE 0.01 1.25 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Yongqun He, Erica Marcos A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rash AE Comvax-associated otitis media AE 0.01 1.25 0.115 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an otitis media AE Havrix-associated injection-site muscular soreness AE 18 0.23 18 2 0.21 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated headache AE 0.9 18 2 Yongqun He, Erica Marcos A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated headache AE 18 0.14 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Yongqun He, Erica Marcos A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an headache AE Havrix-associated injection-site pain AE 2.08 0.92 0.32 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated injection-site redness AE 2.08 0.92 0.29 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Yongqun He, Erica Marcos A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site redness AE Havrix-associated irritability AE 2.08 0.92 0.42 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an irritability AE Havrix-associated drowsiness 2.08 0.92 0.28 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Yongqun He, Erica Marcos A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an drowsiness Havrix-associated decreased appetite AE 2.08 0.92 0.28 Yongqun He, Erica Marcos A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an decreased appetite AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Vaqta-associated injection-site erythema AE 1 1.92 0.212 Yongqun He, Erica Marcos A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated fever AE 1 1.92 0.164 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated injection-site pain AE 1 1.92 0.37 19 0.67 18 2 0.187 Yongqun He, Erica Marcos A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated injection-site tenderness AE 19 0.67 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site tenderness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Yongqun He, Erica Marcos Vaqta-associated injection-site muscular soreness AE 19 0.67 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site muscular soreness AE Vaqta-associated injection-site warmth AE 19 0.182 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site warmth AE Yongqun He, Erica Marcos Vaqta-associated headache AE 19 0.161 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Yongqun He, Erica Marcos Twinrix-associated injection-site muscular soreness AE 0.41 0.35 18 A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an injection-site muscular soreness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf Yongqun He, Erica Marcos Twinrix-associated injection-site redness AE 0.11 0.08 18 A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf Yongqun He, Erica Marcos Twinrix-associated headache AE 0.13 0.22 18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an headache AE Twinrix-associated fatigue AE 0.11 0.14 18 A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an fatigue AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf Yongqun He, Erica Marcos Engerix-B-associated injection-site muscular soreness AE 0 0.22 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224503.pdf Yongqun He, Erica Marcos A Engerix-B vaccine adverse event that is associated with an administration of Engerix-B and displays an injection-site muscular soreness AE Engerix-B-associated fatigue AE 0 0.14 A Engerix-B vaccine adverse event that is associated with an administration of Engerix-B and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224503.pdf Recombivax HB-associated irritability AE 0.01 0 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated fever AE 0.01 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an fever AE Recombivax HB-associated diarrhea AE 0.01 0 Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an diarrhea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated fatigue AE 0.01 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an fatigue AE Recombivax HB-associated decreased appetite AE 0.01 0 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an decreased appetite AE Recombivax HB-associated rhinitis AE 0.01 0 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an rhinitis AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Yongqun He, Erica Marcos Recombivax HB-associated injection-site muscular soreness AE 0.01 18 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site pain AE 0.01 18 Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site tenderness AE 0.01 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site tenderness AE Yongqun He, Erica Marcos Recombivax HB-associated injection-site pruritus AE 0.01 18 Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site pruritus AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site erythema AE 0.01 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site erythema AE Yongqun He, Erica Marcos Recombivax HB-associated ecchymosis AE 0.01 18 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an ecchymosis AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Yongqun He, Erica Marcos Recombivax HB-associated local swelling AE 0.01 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an local swelling AE Recombivax HB-associated injection-site warmth AE 0.01 18 Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site warmth AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated skin nodule AE 0.01 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an skin nodule AE Recombivax HB-associated headache AE 0.01 18 Yongqun He, Erica Marcos A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated malaise AE 0.01 18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an malaise AE Recombivax HB-associated nausea AE 0.01 18 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an nausea AE Yongqun He, Erica Marcos Recombivax HB-associated pharyngitis AE 0.01 18 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an pharyngitis AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Yongqun He, Erica Marcos Recombivax HB-associated upper respiratory tract infection AE 0.01 18 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an upper respiratory tract infection AE Gardasil-associated headache AE 9 26 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Yongqun He, Erica Marcos A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an headache AE Gardasil-associated fever AE 0.01 9 26 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an fever AE Gardasil-associated nausea AE 0.01 9 26 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Yongqun He, Erica Marcos A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an nausea AE Gardasil-associated dizziness AE 0.01 9 26 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Yongqun He, Erica Marcos A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an dizziness AE Gardasil-associated injection-site pain AE 0.01 9 26 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated local swelling AE 0.01 9 26 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Yongqun He, Erica Marcos Gardasil-associated injection-site erythema AE 0.01 9 26 Yongqun He, Erica Marcos A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated injection-site pruritus AE 0.01 9 26 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Yongqun He, Erica Marcos A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site pruritus AE Gardasil-associated hematoma, bruise, ecchymoses AE 0.01 9 26 Yongqun He, Erica Marcos A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an hematoma, bruise, ecchymoses AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Cervarix-associated injection-site pain AE 0.2 9 25 Yongqun He, Erica Marcos A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated injection-site redness AE 0.2 9 25 Yongqun He, Erica Marcos A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated local swelling AE 0.2 9 25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an local swelling AE Yongqun He, Erica Marcos Cervarix-associated fatigue AE 0.2 9 25 Yongqun He, Erica Marcos A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an fatigue AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated headache AE 0.2 9 25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Yongqun He, Erica Marcos A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an headache AE Cervarix-associated myalgia AE 0.2 9 25 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Yongqun He, Erica Marcos Cervarix-associated gastrointestinal disorder AE 0.2 9 25 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an gastrointestinal disorder AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Yongqun He, Erica Marcos Cervarix-associated arthralgia AE 0.2 9 25 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an arthralgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Yongqun He, Erica Marcos Ixiaro-associated injection-site pain AE 0.1 17 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf Yongqun He, Erica Marcos A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an injection-site pain AE Ixiaro-associated injection-site tenderness AE 0.1 17 A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf Ixiaro-associated headache AE 0.1 17 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an headache AE Yongqun He, Erica Marcos Ixiaro-associated myalgia AE 0.1 17 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an myalgia AE JE-Vax-associated injection-site tenderness AE 1 0.2 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf Yongqun He, Erica Marcos A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an injection-site tenderness AE JE-Vax-associated injection-site redness AE 1 0.2 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf Yongqun He, Erica Marcos JE-Vax-associated local swelling AE 1 0.2 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an local swelling AE JE-Vax-associated fever AE 1 0.1 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated headache AE 1 0.1 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated malaise AE 1 0.1 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an malaise AE JE-Vax-associated rash AE 1 0.1 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an rash AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf Yongqun He, Erica Marcos JE-Vax-associated chills AE 1 0.1 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an chills AE JE-Vax-associated dizziness AE 1 0.1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf Yongqun He, Erica Marcos A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an dizziness AE JE-Vax-associated myalgia AE 1 0.1 Yongqun He, Erica Marcos A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated nausea AE 1 0.1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf Yongqun He, Erica Marcos A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an nausea AE JE-Vax-associated vomiting AE 1 0.1 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an vomiting AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf Yongqun He, Erica Marcos JE-Vax-associated abdominal pain AE 1 0.1 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an abdominal pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf Yongqun He, Erica Marcos ProQuad-associated injection-site pain AE 0.05 12 1 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf Yongqun He, Erica Marcos ProQuad-associated injection-site tenderness AE 0.05 12 1 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated injection-site muscular soreness AE 0.05 12 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos ProQuad-associated injection-site erythema AE 0.05 12 1 Yongqun He, Erica Marcos A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated local swelling AE 0.05 12 1 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf Yongqun He, Erica Marcos ProQuad-associated fever AE 0.05 12 1 Yongqun He, Erica Marcos A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated irritability AE 0.05 12 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf Yongqun He, Erica Marcos A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an irritability AE ProQuad-associated rash AE 0.05 12 1 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf Menveo-associated injection-site erythema AE 10 2 0.23 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Yongqun He, Erica Marcos Menveo-associated irritability AE 10 2 0.18 Yongqun He, Erica Marcos A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an irritability AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated injection-site induration AE 10 2 0.16 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site induration AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Yongqun He, Erica Marcos Menveo-associated sleepiness AE 10 2 0.14 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Yongqun He, Erica Marcos A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an sleepiness AE Menveo-associated injection-site pain AE 13 55 0.41 10 2 0.31 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site pain AE Yongqun He, Erica Marcos Menveo-associated headache AE 13 55 0.3 10 2 0.11 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Yongqun He, Erica Marcos A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an headache AE Menveo-associated myalgia AE 13 55 0.13 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated malaise AE 13 55 0.16 10 2 0.12 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an malaise AE Menveo-associated nausea AE 13 55 0.1 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf MenHibrix-associated injection-site pain AE 0.15 0.46 1.5 0.115 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf Yongqun He, Erica Marcos MenHibrix-associated injection-site redness AE 0.15 0.46 1.5 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf Yongqun He, Erica Marcos A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an injection-site redness AE MenHibrix-associated local swelling AE 0.15 0.46 1.5 0.115 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf Yongqun He, Erica Marcos MenHibrix-associated irritability AE 0.62 0.71 1.5 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf Yongqun He, Erica Marcos A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an irritability AE MenHibrix-associated drowsiness 0.63 0.49 1.5 0.115 Yongqun He, Erica Marcos A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an drowsiness WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated decreased appetite AE 0.3 0.34 1.5 0.115 Yongqun He, Erica Marcos A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an decreased appetite AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated fever AE 0.11 0.26 1.5 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an fever AE Yongqun He, Erica Marcos Menactra-associated injection-site tenderness AE 0.01 1 0.75 Yongqun He, Erica Marcos A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site tenderness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated injection-site erythema AE 0.01 1 0.75 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Yongqun He, Erica Marcos Menactra-associated local swelling AE 0.01 1 0.75 0.01 55 2 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an local swelling AE Yongqun He, Erica Marcos Menactra-associated irritability AE 0.01 1 0.75 0.01 10 2 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Yongqun He, Erica Marcos A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an irritability AE Menactra-associated crying abnormal AE 0.01 1 0.75 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an crying abnormal AE Yongqun He, Erica Marcos Menactra-associated drowsiness 0.01 1 0.75 0.01 10 2 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an drowsiness Menactra-associated decreased appetite AE 0.01 1 0.75 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an decreased appetite AE Yongqun He, Erica Marcos Menactra-associated vomiting AE 0.01 1 0.75 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated fever AE 0.01 1 0.75 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Yongqun He, Erica Marcos A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an fever AE Menactra-associated injection-site pain AE 0.01 55 2 Yongqun He, Erica Marcos A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated injection-site redness AE 0.01 55 2 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Yongqun He, Erica Marcos Menactra-associated injection-site induration AE 0.01 55 2 Yongqun He, Erica Marcos A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site induration AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated anorexia AE 0.01 55 2 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an anorexia AE Yongqun He, Erica Marcos Menactra-associated diarrhea AE 0.01 55 2 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an diarrhea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Yongqun He, Erica Marcos Menactra-associated headache AE 0.01 11 55 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an headache AE Yongqun He, Erica Marcos Menactra-associated fatigue AE 0.01 11 55 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an fatigue AE Menactra-associated malaise AE 0.01 11 55 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an malaise AE Menactra-associated arthralgia AE 0.01 11 55 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an arthralgia AE Menomune-A/C/Y/W-135-associated injection-site pain AE 0.1 10 2 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site pain AE Menomune-A/C/Y/W-135-associated drowsiness 0.1 10 2 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Yongqun He, Erica Marcos A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an drowsiness Menomune-A/C/Y/W-135-associated irritability AE 0.1 10 2 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an irritability AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Yongqun He, Erica Marcos Menomune-A/C/Y/W-135-associated diarrhea AE 0.1 11 55 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an diarrhea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Yongqun He, Erica Marcos Menomune-A/C/Y/W-135-associated injection-site pain AE 0.1 11 55 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Yongqun He, Erica Marcos Menomune-A/C/Y/W-135-associated injection-site redness AE 0.1 11 55 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site redness AE Menomune-A/C/Y/W-135-associated injection-site induration AE 0.1 11 55 Yongqun He, Erica Marcos A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site induration AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated headache AE 0.1 11 55 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated fatigue AE 0.1 11 55 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an fatigue AE Menomune-A/C/Y/W-135-associated malaise AE 0.1 11 55 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated arthralgia AE 0.1 11 55 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an arthralgia AE Menomune-A/C/Y/W-135-associated diarrhea AE 0.1 11 55 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Yongqun He, Erica Marcos A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an diarrhea AE Pneumovax 23-associated injection-site pain AE 50 0.6 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Yongqun He, Erica Marcos Pneumovax 23-associated injection-site muscular soreness AE 50 0.6 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site muscular soreness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Yongqun He, Erica Marcos Pneumovax 23-associated injection-site tenderness AE 50 0.6 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site tenderness AE Pneumovax 23-associated local swelling AE 50 0.203 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated injection-site induration AE 50 0.203 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Yongqun He, Erica Marcos A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site induration AE Pneumovax 23-associated injection-site erythema AE 50 0.164 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated headache AE 50 0.176 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated asthenia AE 50 0.132 Yongqun He, Erica Marcos A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an asthenia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated fatigue AE 50 0.132 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an fatigue AE Yongqun He, Erica Marcos Pneumovax 23-associated myalgia AE 50 0.119 Yongqun He, Erica Marcos A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Prevnar-associated injection-site erythema AE 0.58 9 0.1723 Yongqun He, Erica Marcos A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site erythema AE Prevnar-associated injection-site induration AE 0.58 9 0.15 Yongqun He, Erica Marcos A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site induration AE Prevnar-associated injection-site tenderness AE 0.58 9 0.29 A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site tenderness AE Yongqun He, Erica Marcos Prevnar 13-associated injection-site tenderness AE 0.5 0.17 1.25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site tenderness AE Prevnar 13-associated injection-site redness AE 0.1 50 0.2 0.17 1.25 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos Prevnar 13-associated local swelling AE 0.1 50 0.2 0.17 1.25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an local swelling AE Prevnar 13-associated decreased appetite AE 0.1 50 0.4 0.17 1.25 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an decreased appetite AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos Prevnar 13-associated decreased sleep AE 0.4 0.17 1.25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an decreased sleep AE Prevnar 13-associated increased sleep AE 0.4 0.17 1.25 Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an increased sleep AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated fever AE 0.2 0.17 1.25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an fever AE Prevnar 13-associated irritability AE 0.7 0.17 1.25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an irritability AE Prevnar 13-associated injection-site pain AE 0.5 50 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos Prevnar 13-associated fatigue AE 0.3 50 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an fatigue AE Yongqun He, Erica Marcos Prevnar 13-associated headache AE 0.2 50 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an headache AE Yongqun He, Erica Marcos Prevnar 13-associated muscle pain AE 0.2 50 Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an muscle pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated joint pain AE 0.1 50 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an joint pain AE Yongqun He, Erica Marcos Prevnar 13-associated arm motion limitation AE 0.1 50 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an arm motion limitation AE Prevnar 13-associated chills AE 0.05 50 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an chills AE Prevnar 13-associated rash AE 0.05 50 Yongqun He, Erica Marcos A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an rash AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf IPOL-associated injection-site erythema AE 0.17 1.5 0.32 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf Yongqun He, Erica Marcos IPOL-associated injection-site induration AE 0.17 1.5 0.01 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site induration AE Yongqun He, Erica Marcos IPOL-associated injection-site pain AE 0.17 1.5 0.13 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf Yongqun He, Erica Marcos IPOL-associated fever AE 0.17 1.5 0.38 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an fever AE Yongqun He, Erica Marcos IPOL-associated irritability AE 0.17 1.5 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated sleepiness AE 0.17 1.5 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an sleepiness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf Yongqun He, Erica Marcos IPOL-associated fussiness AE 0.17 1.5 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an fussiness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated crying abnormal AE 0.17 1.5 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an crying abnormal AE Yongqun He, Erica Marcos Imovax Rabies-associated injection-site pain AE 0 0.25 Yongqun He, Erica Marcos A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated injection-site erythema AE 0 0.25 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Yongqun He, Erica Marcos Imovax Rabies-associated local swelling AE 0 0.25 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated itching 0 0.25 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Yongqun He, Erica Marcos A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an itching Imovax Rabies-associated headache AE 0 0.2 Yongqun He, Erica Marcos A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated nausea AE 0 0.2 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an nausea AE Yongqun He, Erica Marcos Imovax Rabies-associated abdominal pain AE 0 0.2 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an abdominal pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated muscle ache AE 0 0.2 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an muscle ache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Yongqun He, Erica Marcos Imovax Rabies-associated dizziness AE 0 0.2 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an dizziness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf RabAvert-associated injection-site erythema AE 0 Yongqun He, Erica Marcos A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site erythema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated injection-site induration AE 0 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated injection-site pain AE 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf Yongqun He, Erica Marcos A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site pain AE RabAvert-associated asthenia AE 0 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an asthenia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf Yongqun He, Erica Marcos RabAvert-associated fatigue AE 0 Yongqun He, Erica Marcos A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an fatigue AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated fever AE 0 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf Yongqun He, Erica Marcos RabAvert-associated headache AE 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf Yongqun He, Erica Marcos A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an headache AE RabAvert-associated myalgia AE 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an myalgia AE Yongqun He, Erica Marcos RabAvert-associated malaise AE 0 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated arthralgia AE 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an arthralgia AE Yongqun He, Erica Marcos RabAvert-associated dizziness AE 0 Yongqun He, Erica Marcos A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an dizziness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated lymphadenopathy AE 0 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an lymphadenopathy AE RabAvert-associated nausea AE 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf Yongqun He, Erica Marcos A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an nausea AE RabAvert-associated rash AE 0 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf Rotarix-associated irritability AE 0.05 0.46 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Yongqun He, Erica Marcos A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an irritability AE Rotarix-associated cough 0.05 0.46 0.115 Yongqun He, Erica Marcos A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an cough WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated runny nose 0.05 0.46 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an runny nose Yongqun He, Erica Marcos Rotarix-associated fever AE 0.05 0.46 0.115 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated decreased appetite AE 0.05 0.46 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Yongqun He, Erica Marcos A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an decreased appetite AE Rotarix-associated vomiting AE 0.05 0.46 0.115 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an vomiting AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Yongqun He, Erica Marcos RotaTeq-associated diarrhea AE 0.62 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an diarrhea AE Yongqun He, Erica Marcos RotaTeq-associated vomiting AE 0.62 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf Yongqun He, Erica Marcos A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an vomiting AE RotaTeq-associated irritability AE 0.62 0.115 Yongqun He, Erica Marcos A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an irritability AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated otitis media AE 0.62 0.115 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an otitis media AE Yongqun He, Erica Marcos RotaTeq-associated nasopharyngitis AE 0.62 0.115 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an nasopharyngitis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated bronchospasm AE 0.62 0.115 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an bronchospasm AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf Yongqun He, Erica Marcos Meruvax II-associated fever AE 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Yongqun He, Erica Marcos A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an fever AE Meruvax II-associated syncope AE 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Yongqun He, Erica Marcos A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an syncope AE Meruvax II-associated headache AE 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an headache AE Yongqun He, Erica Marcos Meruvax II-associated dizziness AE 1 Yongqun He, Erica Marcos A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an dizziness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated malaise AE 1 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an malaise AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Yongqun He, Erica Marcos Meruvax II-associated irritability AE 1 Yongqun He, Erica Marcos A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an irritability AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated vasculitis AE 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an vasculitis AE Yongqun He, Erica Marcos Meruvax II-associated diarrhea AE 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an diarrhea AE Yongqun He, Erica Marcos Meruvax II-associated vomiting AE 1 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Yongqun He, Erica Marcos A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an vomiting AE Meruvax II-associated nausea AE 1 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an nausea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Yongqun He, Erica Marcos ACAM2000-associated lymphadenitis AE 0 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an lymphadenitis AE ACAM2000-associated malaise AE 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an malaise AE Yongqun He, Erica Marcos ACAM2000-associated fatigue AE 0 Yongqun He, Erica Marcos A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an fatigue AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated fever AE 0 A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf Yongqun He, Erica Marcos ACAM2000-associated myalgia AE 0 Yongqun He, Erica Marcos A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated headache AE 0 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf Yongqun He, Erica Marcos A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an headache AE Tetanus and Diptheria Toxoids Absorbed-associated injection-site pain AE 7 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site pain AE Tetanus and Diptheria Toxoids Absorbed-associated injection-site tenderness AE 7 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated injection-site erythema AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site erythema AE Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated injection-site induration AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Yongqun He, Erica Marcos A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site induration AE Tetanus and Diptheria Toxoids Absorbed-associated injection-site pruritus AE 7 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site pruritus AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated local swelling AE 7 Yongqun He, Erica Marcos A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated oedema, swelling dropsy 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an oedema, swelling dropsy Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated pyrexia AE 7 Yongqun He, Erica Marcos A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an pyrexia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated malaise AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an malaise AE Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated dizziness AE 7 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an dizziness AE Tetanus and Diptheria Toxoids Absorbed-associated headache AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an headache AE Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated convulsion AE 7 Yongqun He, Erica Marcos A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an convulsion AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated myalgia AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Yongqun He, Erica Marcos A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an myalgia AE Tetanus and Diptheria Toxoids Absorbed-associated musculoskeletal stiffness AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an musculoskeletal stiffness AE Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated musculoskeletal pain AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an musculoskeletal pain AE Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated arthralgia AE 7 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an arthralgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Yongqun He, Erica Marcos Tetanus and Diptheria Toxoids Absorbed-associated rash AE 7 Yongqun He, Erica Marcos A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an rash AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated nausea AE 7 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an nausea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Yongqun He, Erica Marcos Decavac-associated injection-site pain AE 17 11 0.71 18 64 0.63 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Yongqun He, Erica Marcos A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an injection-site pain AE Decavac-associated headache AE 17 11 0.4 18 64 0.34 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated local swelling AE 0.1 11 64 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated injection-site erythema AE 0.1 11 64 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated pain AE 0.1 11 64 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated muscular weakness AE 0.1 11 64 Yongqun He, Erica Marcos A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an muscular weakness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated tiredness AE 0.1 11 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an tiredness AE Yongqun He, Erica Marcos Decavac-associated diarrhea AE 0.1 11 64 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated chills AE 0.1 17 11 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an chills AE Yongqun He, Erica Marcos Decavac-associated nausea AE 0.1 17 11 Yongqun He, Erica Marcos A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an nausea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated joint swelling AE 0.1 17 11 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an joint swelling AE Yongqun He, Erica Marcos Tenivac-associated injection-site pain AE 11 59 0.783 60 0.353 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an injection-site pain AE Tenivac-associated headache AE 7 0.179 Yongqun He, Erica Marcos A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated injection-site redness AE 0.1 7 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated local swelling AE 0.1 7 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an local swelling AE Tenivac-associated malaise AE 0.1 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an malaise AE Yongqun He, Erica Marcos Tenivac-associated muscular weakness AE 0.1 7 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an muscular weakness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated joint pain AE 0.1 7 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an joint pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tetanus Toxoid-associated injection-site redness AE 7 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Yongqun He, Erica Marcos Tetanus Toxoid-associated injection-site warmth AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site warmth AE Yongqun He, Erica Marcos Tetanus Toxoid-associated injection-site edema AE 7 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated injection-site induration AE 7 Yongqun He, Erica Marcos A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site induration AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated induration with tenderness AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an induration with tenderness AE Yongqun He, Erica Marcos Tetanus Toxoid-associated urticaria AE 7 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an urticaria AE Tetanus Toxoid-associated rash AE 7 Yongqun He, Erica Marcos A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an rash AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated malaise AE 7 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an malaise AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Yongqun He, Erica Marcos Tetanus Toxoid-associated fever AE 7 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated pain AE 7 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Yongqun He, Erica Marcos Tetanus Toxoid-associated hypotension AE 7 Yongqun He, Erica Marcos A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an hypotension AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated nausea AE 7 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an nausea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Yongqun He, Erica Marcos Tetanus Toxoid-associated arthralgia AE A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid Absorbed-associated injection-site redness AE 7 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site redness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Yongqun He, Erica Marcos Tetanus Toxoid Absorbed-associated injection-site warmth AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site warmth AE Yongqun He, Erica Marcos Tetanus Toxoid Absorbed-associated injection-site edema AE 7 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated injection-site induration AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site induration AE Yongqun He, Erica Marcos Tetanus Toxoid Absorbed-associated induration with tenderness AE 7 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an induration with tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated urticaria AE 7 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an urticaria AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated rash AE 7 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an rash AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Yongqun He, Erica Marcos Tetanus Toxoid Absorbed-associated malaise AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an malaise AE Yongqun He, Erica Marcos Tetanus Toxoid Absorbed-associated fever AE 7 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an fever AE Tetanus Toxoid Absorbed-associated pain AE 7 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an pain AE Tetanus Toxoid Absorbed-associated hypotension AE 7 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Yongqun He, Erica Marcos A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an hypotension AE Tetanus Toxoid Absorbed-associated nausea AE 7 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an nausea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Yongqun He, Erica Marcos Tetanus Toxoid Absorbed-associated arthralgia AE 7 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an arthralgia AE Adacel-associated injection-site pain AE 17 11 0.778 18 64 0.657 A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Yongqun He, Erica Marcos Adacel-associated local swelling AE 17 11 0.209 18 64 0.21 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an local swelling AE Adacel-associated injection-site erythema AE 17 11 0.208 18 64 0.247 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an injection-site erythema AE Yongqun He, Erica Marcos Adacel-associated fatigue AE 17 11 0.151 Yongqun He, Erica Marcos A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an fatigue AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Adacel-associated headache AE 17 11 0.437 18 64 0.339 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Yongqun He, Erica Marcos A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an headache AE Adacel-associated muscular weakness AE 17 11 0.304 18 0.219 Yongqun He, Erica Marcos A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an muscular weakness AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Boostrix-associated injection-site pain AE 0.15 18 10 0.15 19 64 0.15 65 Yongqun He, Erica Marcos A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated injection-site redness AE 0.15 18 10 0.15 19 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site redness AE Yongqun He, Erica Marcos Boostrix-associated local swelling AE 0.15 18 10 0.15 19 64 Yongqun He, Erica Marcos A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an local swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated injection-site edema AE 0.15 18 10 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site edema AE Yongqun He, Erica Marcos Boostrix-associated headache AE 0.15 18 10 0.15 19 64 Yongqun He, Erica Marcos A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated fatigue AE 0.15 18 10 0.15 19 64 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an fatigue AE Yongqun He, Erica Marcos Boostrix-associated gastrointestinal disorder AE 0.15 18 10 0.15 19 64 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an gastrointestinal disorder AE Vivotif-associated abdominal pain AE A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an abdominal pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Yongqun He, Erica Marcos Vivotif-associated nausea AE 6 0.058 Yongqun He, Erica Marcos A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an nausea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated headache AE 6 0.048 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an headache AE Yongqun He, Erica Marcos Vivotif-associated fever AE 6 0.033 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an fever AE Vivotif-associated diarrhea AE 6 0.029 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an diarrhea AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Yongqun He, Erica Marcos Vivotif-associated vomiting AE 6 0.015 Yongqun He, Erica Marcos A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an vomiting AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated rash AE 6 0.01 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an rash AE Yongqun He, Erica Marcos Typhim Vi-associated injection-site tenderness AE 40 18 0.975 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Yongqun He, Erica Marcos A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site tenderness AE Typhim Vi-associated injection-site pain AE 40 18 0.336 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site pain AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Yongqun He, Erica Marcos Typhim Vi-associated injection-site induration AE 40 18 0.0995 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated injection-site erythema AE 40 18 0.044 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site erythema AE Typhim Vi-associated malaise AE 40 18 0.1405 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated headache AE 40 18 0.1225 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an headache AE Typhim Vi-associated myalgia AE 40 18 0.00525 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an myalgia AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Yongqun He, Erica Marcos Typhim Vi-associated nausea AE 40 18 0.00505 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an nausea AE Typhim Vi-associated diarrhea AE 40 18 0.0155 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated irritability AE 40 18 0.071 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Yongqun He, Erica Marcos A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an irritability AE Typhim Vi-associated fever AE 40 18 0.0095 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Yongqun He, Erica Marcos Typhim Vi-associated vomiting AE 40 18 0.0095 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an vomiting AE Yongqun He, Erica Marcos Varivax-associated fever AE 12 1 0.147 13 0.102 A Varivax vaccine adverse event that is associated with an administration of Varivax and displays an fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142813.pdf Yongqun He, Erica Marcos Varivax-associated injection-site adverse event 12 1 0.193 13 0.244 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142813.pdf Yongqun He, Erica Marcos A Varivax vaccine adverse event that is associated with an administration of Varivax and displays an injection-site adverse event YF-Vax-associated headache AE 0.75 Yongqun He, Erica Marcos A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an headache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated myalgia AE 0.75 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an myalgia AE YF-Vax-associated low grade fever AE 0.75 Yongqun He, Erica Marcos A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an low grade fever AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated injection-site edema AE 0.75 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site edema AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf Yongqun He, Erica Marcos YF-Vax-associated hypersensitivity AE 0.75 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an hypersensitivity AE YF-Vax-associated injection-site pain AE 0.75 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site pain AE Yongqun He, Erica Marcos YF-Vax-associated injection-site mass AE 0.75 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site mass AE Zostavax-associated headache AE 0.01 50 WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM132831.pdf A Zostavax vaccine adverse event that is associated with an administration of Zostavax and displays an headache AE Yongqun He, Erica Marcos Zostavax-associated injection-site reaction 0.01 50 A Zostavax vaccine adverse event that is associated with an administration of Zostavax and displays an injection-site reaction Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM132831.pdf Afluria vaccine adverse event An influenza vaccine adverse event that is associated with the administration of Afluria. Yongqun He FluMist vaccine adverse event An influenza vaccine adverse event that is associated with the administration of FluMist. Yongqun He ActHIB vaccine adverse event Yongqun He ACAM2000 vaccine adverse event Yongqun He, Erica Marcos A smallpox vaccine adverse event that is associated with the administration of ACAM2000. Adacel vaccine adverse event Yongqun He time A quality in which events occur in sequence. time viability An organismal quality inhering in a bearer or a population by virtue of the bearer's ability or inability to survive and develop normally or the number of surviving individuals in a given population. viability behavioral quality An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation. PATO:0000186 PATO:0001722 behavioural quality quality physical quality A quality of a single physical entity that exists through action of continuants at the physical level of organisation. physical quality process quality A quality which inheres in an process. PATO:0001236 PATO:0001239 PATO:0001240 See comments of relational quality of a physical entity. quality quality of a process quality of occurrent quality of process relational quality of occurrent quality of a single physical entity A physical object quality which inheres in a single-bearer. quality of a single physical entity physical object quality physical object quality A quality which inheres in a continuant. PATO:0001237 PATO:0001238 PATO:0001241 Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. monadic quality of a continuant monadic quality of an object monadic quality of continuant multiply inhering quality of a physical entity quality quality of a continuant quality of a single physical entity quality of an object quality of continuant snap:Quality A quality which inheres in a continuant. physical object quality organismal quality organismal quality A quality that inheres in an entire organism or part of an organism. PATO:0001995 quality A quality that inheres in an entire organism or part of an organism. organismal quality virulence A quality inhering in a bearer by virtue of the bearer's pathogenicity. virulence nose BTO:0000840 CALOHA:TS-2037 EHDAA2:0001274 EHDAA:1502 EMAPA:16542 EV:0100037 EV:0100370 FMA:46472 GAID:77 MA:0000281 MAT:0000139 MESH:D009666 MIAA:0000139 OpenCyc:Mx4rvViCbJwpEbGdrcN5Y29ycA Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047]. TAO:0000047 The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity. UBERON:0000004 UMLS:C0028429 ZFA:0000047 a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose]. galen:Nose nasal sac nasus nose olfactory apparatus peripheral olfactory organ proboscis the organ that is specialized for smell and is part of the respiratory system the structure of the nose varies across vertebrates. In tetrapods the nose is part of the respiratory system.[PMID:25312359] uberon peripheral nervous system (...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG] A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. AAO:0000429 BAMS:PNS BILA:0000081 BTO:0001028 CALOHA:TS-0808 EFO:0000891 EHDAA2:0001445 EHDAA:2893 EMAPA:16665 EV:0100335 FBbt:00005098 FMA:9903 GAID:715 MA:0000218 MAT:0000338 MESH:D017933 MIAA:0000338 Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO] PNS Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO] TAO:0000142 The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO) UBERON:0000010 UMLS:C0206417 UMLS:C1305921 VHOG:0000399 XAO:0000178 ZFA:0000142 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=247 lateral part of the basal amygdalar nucleus lateral part of the basolateral nucleus nucleus amygdalae basalis, pars lateralis nucleus amygdaloideus basalis, pars lateralis magnocellularis nucleus basalis lateralis amygdalae pars peripherica pars peripherica; systema nervosum periphericum systema nervosum periphericum uberon zone of skin (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG] Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. EHDAA2:0001844 EHDAA:6530 EMAPA:17525 EV:0100152 FMA:86166 GAID:933 MA:0000151 MAT:0000284 MESH:D012867 MIAA:0000284 Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA UBERON:0000014 VHOG:0000860 portion of skin region of skin skin skin region skin zone uberon we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive anatomical boundary A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. AEO:0000192 CARO:0000010 Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. FMA:50705 UBERON:0000015 uberon sense organ AEO:0000094 An organ that is capable of transducing sensory stimulus to the nervous system. BSA:0000121 BTO:0000202 CALOHA:TS-2043 EHDAA2:0001824 EHDAA:500 EMAPA:16192 EMAPA:35955 FBbt:00005155 GAID:63 HAO:0000930 MA:0000017 MESH:D012679 Sinnesorgan UBERON:0000020 UMLS:C0935626 VHOG:0001407 WBbt:0006929 organ of sense organ system organ of sensory organ system organ of sensory system sense organ system organ sensillum sensor sensory organ sensory organ system organ sensory system organ uberon tube Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. UBERON:0000025 anatomical tube duct galen:Tube not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts) tubular uberon appendage AEO:0000193 An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018]. BILA:0000018 BTO:0001492 CARO:0010003 EFO:0000799 EHDAA2:0003193 EV:0100155 FBbt:00007000 HAO:0000144 MAT:0000023 MESH:D005121 MIAA:0000023 Major subdivision of an organism that protrudes from the body[DOS, CARO]. OpenCyc:Mx4rvViC-JwpEbGdrcN5Y29ycA Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]. UBERON:0000026 UMLS:C0598782 VSAO:0000075 XAO:0000218 appendages appendicular extremitaet extremity limbs/digits/tail this is currently a subtype of organism subdivision - which would exclude feathers uberon head AAO:0010335 AEO:0000106 BILA:0000115 BTO:0000282 CALOHA:TS-0436 EFO:0000964 EHDAA2:0003106 EMAPA:31858 FBbt:00000004 FMA:7154 GAID:61 HAO:0000397 MA:0000023 MAT:0000294 MESH:D006257 MIAA:0000294 OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO] Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO] SPD:0000016 TAO:0001114 TGMA:0000002 The head is the anterior-most division of the body [GO]. UBERON:0000033 UMLS:C0018670 VHOG:0001644 Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG] WBbt:0005739 XAO:0003024 ZFA:0001114 adult head cephalic area galen:Head head (volume) uberon serous membrane A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO] FMA:9581 GAID:19 MESH:D012704 TAO:0005425 UBERON:0000042 UMLS:C0036760 ZFA:0005425 a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP] in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA. multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. serosa tunica serosa uberon wall of serous sac tendon AEO:0000091 BTO:0001356 CALOHA:TS-1021 Dense regular connective tissue that connects muscle to bone.[VSAO] Dense regular connective tissue that connects muscle to bone[VSAO]. EHDAA2:0003091 EMAPA:35854 EV:0100149 FMA:9721 GAID:276 MA:0000115 MESH:D013710 OpenCyc:Mx4rvVjefJwpEbGdrcN5Y29ycA Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG] UBERON:0000043 UMLS:C0039508 VHOG:0001286 VSAO:0000073 XAO:0000173 ZFA:0005647 galen:Tendon in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis sinew tendo uberon ganglion A biological tissue mass, most commonly a mass of nerve cell bodies. A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures AAO:0010426 AEO:0000135 BAMS:G BTO:0000497 CALOHA:TS-0397 Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG] EFO:0000899 EHDAA2:0003135 EHDAA:2897 EHDAA:4662 EHDAA:5621 EHDAA:918 EMAPA:32846 EV:0100372 FBbt:00005137 FMA:5884 MA:0002406 MAT:0000207 MAT:0000343 MESH:D005724 MIAA:0000207 MIAA:0000343 Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO] Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO] Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NIFSTD:nlx_anat_100302]. TAO:0000190 TGMA:0001016 TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system. UBERON:0000045 UMLS:C0017067 VHOG:0000156 WBbt:0005189 XAO:0000209 ZFA:0000190 ganglia ganglionic neural ganglion uberon vessel A tubular structure that contains, conveys body fluid, such as blood or lymph. UBERON:0000055 uberon duct A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]. A tubular structure that transports secreted or excreted substances. AAO:0011123 FBbt:00100314 FMA:30320 Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here. TAO:0005171 UBERON:0000058 UMLS:C0687028 XAO:0004000 ZFA:0005171 anatomical duct ducts exocrine duct exocrine gland duct galen:Duct uberon anatomical wall EMAPA:25036 FMA:82482 Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. UBERON:0000060 UBERON:0009915 galen:Wall in FMA, serosa is a wall organ wall uberon wall wall of organ anatomical structure AAO:0010825 AEO:0000003 BILA:0000003 CARO:0000003 EHDAA2:0003003 EMAPA:0 FBbt:00007001 FMA:67135 GAID:781 HAO:0000003 MA:0003000 MESH:D000825 Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. TAO:0000037 TGMA:0001823 UBERON:0000061 VHOG:0001759 WBbt:0000100 XAO:0003000 ZFA:0000037 biological structure connected biological structure uberon organ Anatomical structure that performs a specific function or group of functions [WP]. CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4 CARO:0020004 EFO:0000634 EMAPA:35949 ENVO:01000162 FMA:67498 MA:0003001 OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. UBERON:0000062 UMLS:C0178784 WBbt:0003760 anatomical unit body organ element uberon organ subunit A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction FMA:86140 Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball. Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal. UBERON:0000063 organ region with fixed fiat boundary organ segment segment of organ uberon organ part A multicellular structure that is a part of an organ. AAO:0011124 EFO:0000635 FMA:82472 UBERON:0000064 cardinal organ part currently defined in a very broad sense, may be replaced by more specific classes in the future regional part of organ uberon respiratory tract Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts EHDAA2:0001606 EHDAA:1568 EHDAA:2219 EMAPA:16737 FMA:265130 OpenCyc:Mx4rvvM--pwpEbGdrcN5Y29ycA UBERON:0000065 VHOG:0000393 uberon fully formed stage BTO:0001043 BilaDO:0000004 EFO:0001272 FBdv:00005369 The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. UBERON:0000066 WBls:0000041 XtroDO:0000084 adult stage fully formed animal stage juvenile-adult stage uberon embryo stage part A stage that is part of the embryo stage. UBERON:0000067 embryonic stage part uberon embryo stage A life cycle stage that starts with fertilization and ends with the fully formed embryo. BilaDO:0000002 EV:0300001 FBdv:00005289 FMA:72652 HsapDv:0000002 MmusDv:0000002 OGES:000000 OGES:000022 UBERON:0000068 WBls:0000003 WBls:0000092 WBls:0000102 XAO:1000012 embryogenesis embryonic stage uberon death stage End of the life of an organism. UBERON:0000071 XAO:0000437 XtroDO:0000085 death ncit:Death is an outcome uberon proximo-distal subdivision of respiratory tract An section of a respiratory tract. EMAPA:16737 FMA:45660 MA:0000434 MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole UBERON:0000072 respiratory tract subdivision of respiratory tract uberon regional part of nervous system 2009-06-18T09:00:04Z Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. Melissa Haendel UBERON:0000073 UMLS:C1518256 part of nervous system uberon subdivision of skeletal system Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. FMA:85544 UBERON:0000075 UBERON:0010322 UMLS:C1519343 galen:ComplexSkeletalStructure skeletal system part skeletal system subdivision uberon external ectoderm (or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis EHDAA2:0001968 EHDAA:1494 EHDAA:350 EHDAA:4784 EHDAA:4790 EHDAA:4796 EHDAA:7860 EMAPA:16096 FMA:87656 The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. UBERON:0000076 UMLS:C1515087 merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube) surface (external) ectoderm surface ectoderm uberon post-embryonic stage BilaDO:0000003 In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997) OGES:000010 OGES:000014 OGES:000024 UBERON:0000092 WBls:0000022 WBls:0000093 WBls:0000103 post-hatching stage postembryonic postembryonic stage stage succeeding embryo, including mature structure uberon membrane organ 2009-07-30T05:19:13Z FMA:7145 Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA] UBERON:0000094 cjm membrane membrane of organ uberon life cycle An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. FBdv:00000000 HsapDv:0000001 MmusDv:0000001 OGES:000011 UBERON:0000104 entire life cycle entire lifespan life lifespan ncithesaurus:Life uberon life cycle stage A spatiotemporal region encompassing some part of the life cycle of an organism. BILS:0000105 EFO:0000399 FBdv:00007012 FMA:24120 HsapDv:0000000 MmusDv:0000000 OlatDv:0000010 PdumDv:0000090 UBERON:0000105 WBls:0000002 XAO:1000000 ZFS:0000000 ZFS:0100000 developmental stage ncithesaurus:Developmental_Stage stage the WBls class 'all stages' belongs here as it is the superclass of other WBls stages this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here uberon we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage zygote stage 1-cell stage A stage at which the organism is a single cell produced by means of sexual reproduction. As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG] BILS:0000106 BilaDO:0000005 EFO:0001322 EHDAA:27 EMAPA:16033 FBdv:00005288 PdumDv:0000100 UBERON:0000106 VHOG:0000745 XAO:1000001 ZFS:0000001 fertilized egg stage fertilized egg stage one cell stage one-cell stage uberon zygote zygotum cleavage stage BILS:0000107 BilaDO:0000006 EFO:0001290 FBdv:00000054 MESH:A16.254.270 MmusDv:0000004 OGES:000015 OGES:000020 PdumDv:0000200 The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. UBERON:0000107 XAO:1000004 ZFS:0000046 uberon blastula stage An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. BILS:0000108 BilaDO:0000007 EFO:0001282 HsapDv:0000006 MmusDv:0000007 OGES:000003 OGES:000016 OGES:000021 OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg UBERON:0000108 WBls:0000005 XAO:1000003 ZFS:0000045 consider adding a preceding stage 'morula stage' as part of cleavage uberon gastrula stage A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. BILS:0000109 BilaDO:0000008 EFO:0001296 FBdv:00005317 HsapDv:0000010 MmusDv:0000013 OGES:000004 OGES:000019 UBERON:0000109 WBls:0000010 XAO:1000005 ZFS:0000047 blastocystis trilaminaris stage trilaminar blastocyst stage trilaminar blastoderm stage trilaminar disk stage trilaminar germ stage trilaminar stage uberon neurula stage BILS:0000110 BilaDO:0000009 HsapDv:0000012 MmusDv:0000017 Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. UBERON:0000110 XAO:1000006 uberon organogenesis stage A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. BILS:0000111 BilaDO:0000010 HsapDv:0000015 MmusDv:0000018 OGES:000005 OGES:000032 UBERON:0000111 segmentation stage uberon lung bud BTO:0001643 EHDAA2:0004089 Structure derived from foregut that becomes a lung[GO]. UBERON:0000118 UMLS:C1514420 UMLS:C1514897 clarify successors - include bronchi? gemma pulmonalis gemma respiratoria lung bud primary lung bud respiratory diverticulum uberon neuron projection bundle A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. CARO:0001001 FBbt:00005099 UBERON:0000122 UBERON:0005163 funiculus nerve fiber bundle neural fiber bundle uberon anterior region of body UBERON:0000153 uberon posterior region of body UBERON:0000154 uberon mouth AAO:0010355 BTO:0001090 BTO:0004698 CALOHA:TS-1315 Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO] EFO:0000825 EHDAA2:0001326 EHDAA:542 EMAPA:16262 FBbt:00003126 FMA:49184 First portion of the digestive tract[WP]. The portion of the digestive that develops from the stomodeum GAID:75 MA:0000341 MA:0002474 MAT:0000038 MESH:A.01.456.505.631 MESH:D009055 MIAA:0000038 Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG] OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA TADS:0000040 TAO:0000547 TAO:0000590 TGMA:0000131 TODO - check fly mouthpart. note in uberon we distinguish between the mouth and the oral opening. the mouth is part of the digestive tract. TODO - check isa parent subdivision of head - is it a subdivision of the head or digestive tract The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). UBERON:0000165 VHOG:0000280 VHOG:0000812 XAO:0003029 ZFA:0000547 ZFA:0000590 adult mouth adult mouth cavital oralis cavitas oris cavum oris galen:Mouth http://upload.wikimedia.org/wikipedia/commons/thumb/d/d4/Illu01_head_neck.jpg/200px-Illu01_head_neck.jpg in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips mouth cavity oral oral region oral vestibule regio oralis rima oris some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives stoma stomatodaeum trophic apparatus uberon vestibule of mouth vestibulum oris pair of lungs 1 1 1 1 FMA:68877 OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA The pair of anatomical structures comprised of a left lung and right lung. UBERON:0000170 lungs lungs pair pulmones set of lungs uberon respiration organ EMAPA:17607 Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. SPD:0000428 TGMA:0001247 UBERON:0000171 apparatus respiratorius organ breathing organ gas exchange organ organ of apparatus respiratorius organ of respiratory system respiratory organ respiratory system organ uberon blood A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO] A fluid that is composed of blood plasma and erythrocytes. AAO:0000046 BTO:0000089 CALOHA:TS-0079 EFO:0000296 EHDAA2:0000176 EHDAA:418 EMAPA:16332 ENVO:02000027 EV:0100047 FMA:9670 GAID:965 Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO] MA:0000059 MESH:D001769 MIAA:0000315 OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG] TAO:0000007 This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. UBERON:0000178 UMLS:C0005767 VHOG:0000224 XAO:0000124 ZFA:0000007 galen:Blood portion of blood relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] uberon vertebrate blood whole blood haemolymphatic fluid 2009-04-08T04:38:19Z CARO:0000081 Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. UBERON:0000179 blood or blood analog circulating fluid cjm uberon blastula BILA:0000059 BTO:0000128 GAID:1294 MESH:A16.254.270.274 OGEM:000006 OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula UBERON:0000307 UBERON:0007011 blastosphere blastula embryo uberon throat BTO:0000828 FMA:228738 In anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the trachea and prevents inhalation of food or drink. The throat contains various blood vessels, various pharyngeal muscles, the trachea (windpipe) and the esophagus. The hyoid bone and the clavicle are the only bones located in the throat of mammals. It is sometimes considered a synonym for fauces. [WP,unvetted]. OpenCyc:Mx4rwQtO_JwpEbGdrcN5Y29ycA The hyoid bone and the clavicle are the only bones located in the throat of mammals. UBERON:0000341 UMLS:C0230069 gula gular uberon musculature of body AAO:0000307 Anatomical system that consists of the muscles of the body.[VSAO] BILA:0000088 BTO:0001369 BTO:0001485 EFO:0000801 EMAPA:35578 FBbt:00005069 FMA:72954 MA:0002888 MAT:0000025 MIAA:0000025 The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. UBERON:0000383 VSAO:0000033 XAO:0004042 consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77 muscle system muscle system of body muscular system musculature system muskelsystem set of all muscles set of muscles of body uberon vertebrate muscular system we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA serous gland A gland in which the principal secretory cells are serous secreting cells. BTO:0001837 FMA:62889 UBERON:0000409 glands that secrete watery albuminous material that often contains enzymes[MP:0008052]. uberon bodily secretion A portion of organism substance that is produced by exocrine glands. AEO:0001005 BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions BTO:0002977 BTO:0002979 EMAPA:36535 FMA:9675 MA:0002504 MESH:D012634 UBERON:0000456 UBERON:0006540 UMLS:C1516992 exocrine gland fluid exocrine gland fluid or secretion exocrine gland fluid/secretion exocrine gland secretion external secretion galen:Secretion secreted substance secretion uberon organism substance AAO:0010839 AEO:0000004 BILA:0000004 CALOHA:TS-2101 CARO:0000004 EHDAA2:0003004 EMAPA:35178 FBbt:00007019 FMA:9669 HAO:0000004 MA:0002450 Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. SPD:0000008 TAO:0001487 TGMA:0001824 UBERON:0000463 VHOG:0001726 XAO:0004001 ZFA:0001487 body fluid or substance body substance galen:BodySubstance organism substance portion of body substance portion of organism substance uberon anatomical space AAO:0010110 AEO:0000005 BILA:0000005 CARO:0000005 EHDAA2:0003005 FBbt:00007017 FMA:5897 HAO:0000005 Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. TAO:0001668 TGMA:0001825 UBERON:0000464 UMLS:C0524461 VHOG:0001728 XAO:0003190 ZFA:0001643 anatomical spaces lumen lumen space space uberon material anatomical entity AAO:0010264 AEO:0000006 Anatomical entity that has mass. BILA:0000006 CARO:0000006 EHDAA2:0003006 FBbt:00007016 FMA:67165 HAO:0000006 TAO:0001836 TGMA:0001826 UBERON:0000465 VHOG:0001721 uberon immaterial anatomical entity AAO:0010265 AEO:0000007 Anatomical entity that has no mass. BILA:0000007 CARO:0000007 EHDAA2:0003007 FBbt:00007015 FMA:67112 HAO:0000007 TAO:0001835 TGMA:0001827 UBERON:0000466 VHOG:0001727 immaterial physical anatomical entity uberon anatomical system AAO:0000007 AEO:0000011 BILA:0000011 BSA:0000049 CALOHA:TS-2088 CARO:0000011 EHDAA2:0003011 EHDAA:392 EMAPA:16103 EV:0100000 FBbt:00004856 FMA:7149 HAO:0000011 MA:0000003 Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ TAO:0001439 TGMA:0001831 UBERON:0000467 UMLS:C0460002 VHOG:0001725 WBbt:0005746 WBbt:0005763 XAO:0003002 ZFA:0001439 anatomical systems body system connected anatomical system galen:AnatomicalSystem organ system system uberon multicellular organism AAO:0010026 AEO:0000191 Anatomical structure that is an individual member of a species and consists of more than one cell. BILA:0000012 BSA:0000038 BTO:0000042 CARO:0000012 EFO:0002906 EHDAA2:0003103 EHDAA2:0003191 EHDAA:1 EHDAA:9178 EMAPA:25765 EV:0100016 FBbt:00000001 FMA:256135 HAO:0000012 Koerper TADS:0000001 TAO:0001094 TGMA:0001832 TODO - split body and mc organism? body continues after death stage UBERON:0000468 VHOG:0000671 WBbt:0007833 XAO:0003004 ZFA:0001094 animal body galen:Organism multi-cellular organism ncithesaurus:Whole_Organism organism organismal uberon whole body whole organism organism subdivision AAO:0010053 AEO:0000032 Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. BILA:0000032 CALOHA:TS-2084 CARO:0000032 EFO:0000808 EHDAA2:0003032 EMAPA:36031 FBbt:00007009 FMA:7153 HAO:0000032 MA:0002433 MAT:0000293 MESH:D001829 MIAA:0000293 OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency TAO:0001308 TGMA:0001840 UBERON:0000475 UMLS:C0229962 VHOG:0001758 XAO:0003013 ZFA:0001308 anatomic region body part body region cardinal body part galen:BodyPart uberon acellular anatomical structure AAO:0010268 AEO:0000040 Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. BILA:0000040 CARO:0000040 EHDAA2:0003040 FBbt:00007013 FMA:63863 HAO:0000040 TAO:0000382 TGMA:0001841 UBERON:0000476 XAO:0003162 ZFA:0000382 acellular anatomical structures uberon anatomical cluster AAO:0010009 AEO:0000041 Anatomical group that has its parts adjacent to one another. BILA:0000041 CARO:0000041 EHDAA2:0003041 FBbt:00007277 FMA:49443 HAO:0000041 TADS:0000605 TAO:0001478 TGMA:0001842 UBERON:0000477 VHOG:0001737 Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3] XAO:0003160 ZFA:0001478 uberon tissue AAO:0000607 AAO:0010054 AEO:0000043 BILA:0000043 CALOHA:TS-2090 CARO:0000043 EHDAA2:0003043 EMAPA:35868 FBbt:00007003 FMA:9637 HAO:0000043 MA:0003002 MESH:D014024 Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. TAO:0001477 TGMA:0001844 UBERON:0000479 UMLS:C0040300 VHOG:0001757 WBbt:0005729 XAO:0003040 ZFA:0001477 changed label and definition to reflect CARO2 galen:Tissue portion of tissue simple tissue tissue portion uberon multi-tissue structure AAO:0010048 AEO:0000055 Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. BILA:0000055 CARO:0000055 EHDAA2:0003055 FBbt:00007010 HAO:0000055 TAO:0001488 TGMA:0001847 UBERON:0000481 VHOG:0001762 XAO:0003037 ZFA:0001488 multi-tissue structures uberon epithelium AAO:0000144 AAO:0010055 AEO:0000066 BILA:0000066 BTO:0000416 CALOHA:TS-0288 CARO:0000066 EHDAA2:0003066 EMAPA:32738 FBbt:00007005 FMA:9639 GAID:402 HAO:0000066 MA:0003060 MESH:D004848 Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. TAO:0001486 The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG] UBERON:0000483 UMLS:C0014609 VHOG:0000387 XAO:0003045 ZFA:0001486 epithelial epithelial tissue portion of epithelium uberon multilaminar epithelium AAO:0010059 AEO:0000069 BILA:0000069 BTO:0002074 CARO:0000069 EHDAA2:0003069 Epithelium that consists of more than one layer of epithelial cells.[CARO] Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] FMA:45562 HAO:0000069 TAO:0001494 UBERON:0000486 UMLS:C0682575 XAO:0004006 ZFA:0001494 laminated epithelium stratified epithelium uberon simple squamous epithelium AAO:0010066 AEO:0000070 BILA:0000070 BTO:0002073 CARO:0000070 EHDAA2:0003070 FMA:45565 HAO:0000070 TAO:0001498 UBERON:0000487 UMLS:C0836133 Unilaminar epithelium that consists of a single layer of squamous cells.[CARO] Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA] XAO:0004010 ZFA:0001498 epithelium simplex squamosum simple squamous epithelia uberon cavitated compound organ AAO:0010016 AEO:0000072 BILA:0000072 CARO:0000072 Compound organ that contains one or more macroscopic anatomical spaces. EHDAA2:0003072 FMA:55671 HAO:0000072 TAO:0001490 TGMA:0001857 UBERON:0000489 VHOG:0001730 XAO:0003165 ZFA:0001490 cavitated compound organs cavitated organ this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future uberon unilaminar epithelium AAO:0010062 AEO:0000073 BILA:0000073 BTO:0002073 CARO:0000073 EHDAA2:0003073 Epithelium that consists of a single layer of epithelial cells.[CARO] Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA] FMA:45561 HAO:0000073 TAO:0001495 UBERON:0000490 UMLS:C0682574 XAO:0004007 ZFA:0001495 consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable simple epithelium uberon unilaminar epithelia thoracic segment of trunk EMAPA:35862 FMA:259209 MA:0000022 Subdivision of trunk that lies between the head and the abdomen. UBERON:0000915 anterior subdivision of trunk note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest thorax uberon upper body upper trunk abdomen BTO:0000020 CALOHA:TS-0001 EFO:0000968 EMAPA:35102 EV:0100011 FMA:9577 GAID:16 MA:0000029 MAT:0000298 MESH:A01.047 MIAA:0000298 OpenCyc:Mx4rvVjgyZwpEbGdrcN5Y29ycA The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. UBERON:0000916 Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class abdominal abdominopelvic region abdominopelvis adult abdomen belly celiac celiac region galen:Abdomen uberon embryo AAO:0011035 AEO:0000169 Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. BILA:0000056 BSA:0000039 BTO:0000379 CALOHA:TS-0229 EFO:0001367 EHDAA2:0000002 EHDAA2_RETIRED:0003236 EHDAA:38 EMAPA:16039 FBbt:00000052 FMA:69068 GAID:963 MAT:0000226 MESH:D004622 MIAA:0000019 OGEM:000001 Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA UBERON:0000922 UMLS:C0013935 VHOG:0001766 XAO:0000113 ZFA:0000103 developing organism developmental tissue embryonic embryonic organism uberon germ layer A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. AAO:0000480 BILA:0000035 BTO:0000556 Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] EMAPA:36033 FBbt:00000110 FMA:69069 GAID:1303 MESH:A16.254.425 TAO:0001122 The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] UBERON:0000923 UMLS:C0920502 UMLS:C1708239 VHOG:0001223 XAO:0003011 ZFA:0001122 embryonic germ layer embryonic germ layers embryonic tissue germinal layer primary germ layer uberon ectoderm AAO:0000137 BILA:0000036 BTO:0000315 CALOHA:TS-0216 EFO:0000414 EHDAA2:0000428 EMAPA:16069 EV:0100003 FBbt:00000111 FMA:69070 GAID:1304 MAT:0000155 MAT:0000173 MESH:A16.254.425.273 MIAA:0000173 Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] TAO:0000016 The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] UBERON:0000924 UMLS:C0013574 VHOG:0000153 XAO:0000001 ZFA:0000016 ectodermal embryonic ectoderm uberon endoderm AAO:0000139 BILA:0000038 BTO:0000800 CALOHA:TS-0273 EFO:0002545 EHDAA2:0000436 EMAPA:16062 EV:0100005 FBbt:00000125 FMA:69071 GAID:1305 MAT:0000175 MESH:A16.254.425.407 MIAA:0000175 Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. TAO:0000017 The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] UBERON:0000925 UMLS:C0014144 VHOG:0000154 XAO:0000090 ZFA:0000017 endodermal entoderm uberon mesoderm AAO:0000304 BILA:0000037 BTO:0000839 CALOHA:TS-0623 EFO:0001981 EHDAA2:0001128 EHDAA:124 EHDAA:160 EHDAA:168 EHDAA:183 EMAPA:16083 EV:0100006 FBbt:00000126 FMA:69072 GAID:522 MAT:0000174 MESH:A16.254.425.660 MIAA:0000174 Primary germ layer that is the middle of the embryonic germ layers.[AAO] TAO:0000041 The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] The middle germ layer of the embryo, between the endoderm and ectoderm. UBERON:0000926 UBERON:0003263 UMLS:C0025485 VHOG:0000152 XAO:0000050 ZFA:0000041 embryonic mesoderm entire mesoderm mesodermal mesodermal mantle sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates uberon stomodeum Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO] Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. BTO:0004224 EHDAA2:0001929 EMAPA:16263 FBbt:00000439 FMA:295846 TAO:0001290 TGMA:0000135 This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity. UBERON:0000930 UMLS:C1514977 XAO:0000269 ZFA:0001290 consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence mouth pit mouth primordium oral ectoderm oral pit primitive oral cavity stomatodeum stomodaeum stomodeal stomodeal-hypophyseal primordium the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx uberon heart A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. AAO:0010210 As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG] BILA:0000020 BTO:0000562 Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO] CALOHA:TS-0445 EFO:0000815 EHDAA2:0000738 EHDAA:420 EMAPA:16105 EV:0100018 FMA:7088 GAID:174 Herz@de MA:0000072 MAT:0000036 MESH:D006321 MIAA:0000036 OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO] TAO:0000114 Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" http://dx.doi.org/10.1101/gad.1485706 UBERON:0000948 UMLS:C0018787 VHOG:0000276 XAO:0000064 ZFA:0000114 branchial heart cardiac cardium chambered heart galen:Heart relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] uberon vertebrate heart brain brain (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] AAO:0010478 ABA:Brain BAMS:Br BAMS:Brain BILA:0000135 BTO:0000142 CALOHA:TS-0095 Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO] DHBA:10155 EFO:0000302 EHDAA2:0000183 EHDAA:2641 EHDAA:6485 EMAPA:16894 EV:0100164 FBbt:00005095 FMA:50801 GAID:571 HBA:4005 MA:0000168 MAT:0000098 MESH:D001921 MIAA:0000098 OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA PBA:3999 Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO] TAO:0000008 The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) UBERON:0000955 UMLS:C0006104 UMLS:C1269537 VHOG:0000157 XAO:0000010 ZFA:0000008 encephalon galen:Brain http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=21 requires review for applicability to invertebrate structures, e.g. synganglion suprasegmental levels of nervous system suprasegmental structures synganglion the brain uberon neck AEO:0000108 An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. BTO:0000420 CALOHA:TS-2045 EFO:0000967 EHDAA2:0003108 EMAPA:35587 FMA:7155 GAID:86 MA:0000024 MAT:0000297 MESH:D009333 MIAA:0000297 OpenCyc:Mx4rvVjLF5wpEbGdrcN5Y29ycA UBERON:0000974 UMLS:C0027530 cervical collum galen:Neck neck (volume) true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck. uberon skeletal joint AEO:0000182 Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO] Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO] BTO:0001686 CALOHA:TS-2023 EFO:0000948 EMAPA:35456 FMA:7490 GAID:102 MA:0000319 MAT:0000188 MESH:D007596 MIAA:0000188 OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0003182 TAO:0000367 UBERON:0000982 UMLS:C0022417 VHOG:0001276 VSAO:0000101 XAO:0000171 ZFA:0001596 articular joint articulation galen:Joint joint joints uberon skin epidermis (...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG] A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO] AAO:0000143 BTO:0000404 CALOHA:TS-0283 EFO:0000954 EMAPA:17528 EV:0100153 FMA:70596 GAID:932 MA:0000153 MAT:0000154 MESH:D004817 MIAA:0000154 TAO:0000105 The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO] The outer epithelial layer of the skin that is superficial to the dermis. UBERON:0001003 UMLS:C0014520 VHOG:0000077 XAO:0000028 ZFA:0000105 Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes). epidermal epidermis relationship loss: subclass external integument structures (AAO:0000961)[AAO] skin uberon vertebrate epidermis respiratory system AAO:0000541 Atmungssystem BTO:0000203 CALOHA:TS-1319 EFO:0000804 EHDAA2:0001604 EHDAA:2203 EMAPA:16727 EV:0100036 FMA:7158 Functional system which consists of structures involved in respiration. GAID:78 MA:0000327 MAT:0000030 MESH:D012137 MIAA:0000030 OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA TAO:0000272 The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] UBERON:0001004 UMLS:C0035237 VHOG:0000202 XAO:0000117 ZFA:0000272 apparatus respiratorius apparatus respiratorius respiratory system systema respiratorium uberon respiratory airway An airway through which respiratory air passes in organisms. FMA:265130 This class generically groups trachea and analagous structures throughout metazoa. Consider renaming, as the term could be taken to mean lumen of tracheal system (e.g. in SNOMED). As a grouping class this is quite vague, as it is not clear where the airway begins and ends UBERON:0001005 airway airways uberon digestive system AAO:0000129 An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO] Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. BILA:0000082 BTO:0000058 CALOHA:TS-1293 EFO:0000793 EV:0100056 FBbt:00005055 FMA:7152 GAID:278 MA:0002431 MAT:0000018 MESH:D004064 MIAA:0000018 TADS:0000170 TAO:0000339 UBERON:0001007 WBbt:0005748 XAO:0000125 ZFA:0000339 alimentary system alimentary tract digestive galen:DigestiveSystem gastrointestinal system gut many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class ncithesaurus:Digestive_System uberon circulatory system AAO:0000959 Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO] CALOHA:TS-2103 FBbt:00005057 OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA UBERON:0001009 VHOG:0001248 We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. systema cardiovasculare the cardiovascular system and the lymphatic system are parts of the circulatory system uberon adipose tissue AAO:0000001 AEO:000020 Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG] BTO:0001487 CALOHA:TS-0013 Connective tissue in which fat is stored.[TAO] EFO:0000790 EHDAA2:0003120 EMAPA:35112 EV:0100381 FMA:20110 GAID:920 In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen. MA:0000009 MAT:0000015 MESH:D000273 MIAA:0000015 OpenCyc:Mx4rvVjc_ZwpEbGdrcN5Y29ycA Portion of connective tissue composed of adipocytes enmeshed in areolar tissue TAO:0002134 Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO] UBERON:0001013 UMLS:C0001527 VHOG:0001284 XAO:0003049 ZFA:0005345 adipose adipose bodyfat fat fat tissue fatty depot fatty tissue galen:FattyTissue in FMA this is dense irregular connective tissue relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] uberon musculature A subdivision of the muscular system corresponding to a subdisivision of an organism. AAO:0011066 BTO:0000887 EFO:0001949 EMAPA:32715 EMAPA:35577 FMA:32558 In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here. MA:0000165 OpenCyc:Mx4rvVjmr5wpEbGdrcN5Y29ycA TAO:0000548 UBERON:0001015 UMLS:C0026845 VSAO:0005038 WBbt:0005737 ZFA:0000548 muscle group muscle system muscles muscles set musculature musculature system musculi set of muscles set of skeletal muscles uberon nervous system A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO] AAO:0000324 Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO] BILA:0000079 BTO:0001484 CALOHA:TS-1313 EFO:0000802 EHDAA2:0001246 EHDAA:826 EMAPA:16469 EV:0100162 FBbt:00005093 FMA:7157 GAID:466 MA:0000016 MAT:0000026 MESH:D009420 MIAA:0000026 Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA TAO:0000396 The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. UBERON:0001016 UMLS:C0027763 VHOG:0000402 WBbt:0005735 XAO:0000177 ZFA:0000396 nerve net nervous neural neurological system systema nervosum uberon central nervous system (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] AAO:0000090 BAMS:CNS BILA:0000080 BTO:0000227 CALOHA:TS-0150 CNS EFO:0000908 EHDAA2:0000225 EHDAA:828 EMAPA:16470 EMAPA:16754 EV:0100163 FBbt:00005094 FMA:55675 GAID:570 MA:0000167 MAT:0000457 MESH:D002490 OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA Part of the nervous system which includes the brain and spinal cord.[AAO] TAO:0000012 The brain and spinal cord. Kimmel et al, 1995.[TAO] The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. UBERON:0001017 UMLS:C0927232 VHOG:0000293 XAO:0000215 ZFA:0000012 cerebrospinal axis neuraxis systema nervosum centrale uberon nerve A portion of tissue which is a fasiculated group of axons.[TAO] AAO:0011070 AEO:0000137 An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. BAMS:n BSA:0000098 BTO:0000925 BTO:0001027 CALOHA:TS-0772 EHDAA2:0003137 EHDAA:2851 EHDAA:3776 EHDAA:4657 EMAPA:32808 EMAPA:32815 EV:0100371 FBbt:00005105 FMA:65132 FMA:65239 GAID:747 GAID:758 MA:0000217 MA:0000228 MESH:D010525 OpenCyc:Mx4rwP3lkpwpEbGdrcN5Y29ycA TAO:0007009 UBERON:0001021 UMLS:C0027740 UMLS:C0031119 VHOG:0000901 XAO:0000204 XAO:0003047 ZFA:0007009 galen:Nerve nerves nervous neural subtree peripheral nerve uberon sensory system AAO:0000555 An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG] Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. BAMS:SEN BILA:0000099 EFO:0000805 EHDAA2:0003094 EMAPA:16192 FBbt:00005827 FMA:75259 MA:0002442 MAT:0000031 MIAA:0000031 TAO:0000282 UBERON:0001032 VHOG:0001674 XAO:0003194 ZFA:0000282 note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs organa sensuum organa sensuum sense organ subsystem sense organs sense organs set sensory organ system sensory subsystem sensory systems set of sense organs uberon gustatory system AAO:0010577 BILA:0000143 EFO:0000830 FMA:7194 MA:0002446 MAT:0000275 MIAA:0000275 TAO:0001101 The sensory system for the sense of taste. The sensory system for the sense of taste[NIFSTD:nlx_anat_090803]. The sensory system used for the sense of taste.[AAO] UBERON:0001033 XAO:0003197 ZFA:0001101 gustatory gustatory organ system in ZFA and MA this is a subtype of sensory system. we should change sensory system to disambiguate parts and wholes taste system uberon foregut AAO:0011042 Anterior subdivision of a digestive tract. BILA:0000085 BTO:0000507 EHDAA2:0000557 EHDAA:520 EMAPA:16548 FBbt:00005379 FMA:45616 MA:0001526 Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure TGMA:0001014 The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder. The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] UBERON:0001041 UMLS:C0231051 VHOG:0000285 XAO:0000232 praeenteron proenteron uberon primordium AEO:0000171 BTO:0001886 EFO:0001652 EHDAA2:0003171 FBbt:00005495 FMA:86589 MAT:0000482 Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. UBERON:0001048 UMLS:C0678727 XAO:0003043 bud future organ placode primordia rudiment uberon neural tube (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0010617 BTO:0001057 CALOHA:TS-2371 DHBA:10154 EHDAA2:0001254 EHDAA:2869 EHDAA:908 EMAPA:16164 EMAPA:16530 EMAPA:16757 FMA:293882 Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO] In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. MAT:0000069 MIAA:0000069 TAO:0001135 The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG] The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium UBERON:0001049 UMLS:C0231024 VHOG:0000307 XAO:0003204 ZFA:0001135 neural primordium presumptive central nervous system tubus neuralis uberon anatomical entity AAO:0010841 AEO:0000000 BILA:0000000 Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. CARO:0000000 EHDAA2:0002229 FBbt:10000000 FBbt_root:00000000 FMA:62955 HAO:0000000 MA:0000001 TAO:0100000 TGMA:0001822 UBERON:0001062 UMLS:C1515976 XAO:0000000 ZFA:0100000 uberon synovial fluid BTO:0001339 CALOHA:TS-0996 ENVO:02000039 FMA:12277 GAID:265 MA:0002544 MESH:D013582 Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO] TAO:0005154 Transudate contained in the synovial cavity of joints, and in the cavity of tendon sheaths and bursae. UBERON:0001090 UMLS:C0039097 ZFA:0005154 galen:SynovialFluid joint fluid uberon skeletal muscle tissue AAO:0011099 BTO:0001103 EFO:0000888 EHDAA2:0001842 EHDAA:2923 EHDAA:5035 EHDAA:5043 EHDAA:5978 EHDAA:5984 EHDAA:8277 EHDAA:8291 EHDAA:8326 EHDAA:9146 EMAPA:32716 EV:0100377 FMA:14069 GAID:141 MA:0002439 MAT:0000302 MESH:A.02.633.567 MIAA:0000302 Muscle tissue that consists primarily of skeletal muscle fibers. Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO] OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA SCTID:426215008 TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Consider FBbt:00005073 - somatic muscle. TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle. This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG] Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA] Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]. Striated muscle tissue under control of the somatic nervous system. It is one of three major muscle types, the others being cardiac and smooth muscle. As its name suggests, most skeletal muscle is attached to bones by bundles of collagen fibers known as tendons. Skeletal muscle is made up of individual components known as muscle fibers. These fibers are formed from the fusion of developmental myoblasts. The myofibers are long, cylindrical, multinucleated cells composed of actin and myosin myofibrils repeated as a sarcomere, the basic functional unit of the cell and responsible for skeletal muscle's striated appearance and forming the basic machinery necessary for muscle contraction. The term muscle refers to multiple bundles of muscle fibers held together by connective tissue[WP]. UBERON:0001134 UBERON:FMA_14069-MA_0002439 UMLS:C0242692 VHOG:0000319 XAO:0000174 ZFA:0005277 ncithesaurus:Skeletal_Muscle_Tissue skeletal muscle skeletal muscle skeletal muscle organ skeletal muscle system somatic muscle uberon mesothelium AEO:0000111 BTO:0002422 CALOHA:TS-1183 EHDAA2_RETIRED:0003111 EHDAA:2331 EHDAA:2349 EHDAA:295 EHDAA:6073 EHDAA:640 EHDAA:646 EMAPA:32856 FMA:14074 MA:0000565 Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. http://en.wikipedia.org/wiki/ The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). UBERON:0001136 UMLS:C0086610 uberon dorsum A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. BTO:0001713 CALOHA:TS-2223 EFO:0001405 FMA:14181 GAID:30 In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body MESH:A01.176 OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA UBERON:0001137 UMLS:C0004600 back back of body proper dorsal dorsal part of organism galen:Back uberon skeletal system AAO:0000566 Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO] Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO] BTO:0001486 By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG] CALOHA:TS-1320 EFO:0000806 EHDAA2:0003168 EMAPA:35773 FMA:23881 GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates MA:0000018 OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA Skelettsystem System that provides physical support to the organism.[AAO] TAO:0000434 UBERON:0001434 UMLS:C0037253 VHOG:0001254 VSAO:0000027 XAO:0003060 ZFA:0000434 https://github.com/obophenotype/uberon/wiki/The-skeletal-system set of all bones and joints skeletal skeleton system uberon subdivision of head FMA:24218 UBERON:0001444 XAO:0000040 head region head subdivision region of head uberon face A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). BTO:0003369 CALOHA:TS-2216 EMAPA:32763 FMA:24728 GAID:64 HAO:0000316 MA:0002473 MESH:D005145 OpenCyc:Mx4rvVi5GZwpEbGdrcN5Y29ycA Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face. The area that extends from the median ocellus to the oral foramen[HAO]. The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence) UBERON:0001456 UMLS:C0015450 facia/facies facial galen:Face uberon visage bone element AAO:0000047 AEO:0000082 Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO] BTO:0000140 CALOHA:TS-0088 EFO:0000298 EHDAA2:0003082 EMAPA:32782 ENVO:00002039 EV:0100140 FMA:30317 FMA:5018 GAID:92 MA:0001459 MAT:0000299 MIAA:0000299 OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO] Skeletal element that is composed of bone tissue. Skeletal element that is composed of bone tissue.[VSAO] TAO:0001514 The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG] UBERON:0001474 UMLS:C0262950 VHOG:0001190 VSAO:0000057 XAO:0000169 ZFA:0001514 bone bone element bone organ bones galen:Bone relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] uberon articular capsule An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. FMA:34836 GAID:263 MA:0001519 MESH:D017746 UBERON:0001484 UMLS:C0206207 capsula articularis capsulae articulares check ncita fibrous capsule of joint galen:JointCapsule joint capsule joint fibrous capsule uberon digestive tract A tube extending from the mouth to the anus. AAO:0010023 BILA:0000083 BTO:0000511 BTO:0000545 EHDAA2:0000726 EHDAA:518 EMAPA:16247 FBbt:00003125 FMA also has a term 'gastrointestinal tract', but this includes the liver. FMA:45615 MA:0000917 OpenCyc:Mx4rvVi0GpwpEbGdrcN5Y29ycA TAO:0000112 TGMA:0001819 The alimentary or digestive tract, and associated organs.[TAO] The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] UBERON:0001555 UMLS:C0017189 VHOG:0000309 WBbt:0005743 ZFA:0000112 alimentary canal alimentary tract digestive canal digestive tube enteric tract galen:AlimentaryTract gut gut tube uberon we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509 upper respiratory tract EHDAA2:0002136 EMAPA:17669 FMA:45661 MA:0000442 OpenCyc:Mx4rtT2HwgJMEdyAAADggVbxzQ Some specify that the glottis (vocal cords) is the defining line between the upper and lower respiratory tracts;[2] yet even others make the line at the cricoid cartilage. The FMA includes nose, nasopharynx, oropharynx and larynx[WP] The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea. UBERON:0001557 VHOG:0000406 uberon lower respiratory tract EHDAA2:0001036 EMAPA:16738 FMA:45662 MA:0000435 OpenCyc:Mx4rQRqjUgAKEdyHxgDggVfs8g The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified] UBERON:0001558 VHOG:0000382 uberon muscle organ AAO:0011066 EMAPA:32715 EV:0100146 FMA:5022 GAID:131 It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG] MA:0000015 OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. Portion of tissue composed of contractile fibers.[TAO] TAO:0005145 UBERON:0001630 VHOG:0001245 XAO:0000172 ZFA:0005145 galen:Muscle muscle muscular uberon ear AAO:0011014 BTO:0000368 Both vertebrate and invertebrate auditory organs are thought to have evolved from primitive mechanosensors, but the nature of the ancestral structure and the evolutionary trajectories followed in distinct animal lineages remain unknown. In particular, we do not know how many types of mechanosensor existed in the protostome-deuterostome ancestor from which insects and vertebrates evolved or whether the PDA had an auditory organ.[well established][VHOG] CALOHA:TS-1165 EFO:0000826 EHDAA2:0000423 EHDAA:502 EMAPA:16193 EV:0100353 FMA:52780 GAID:62 MA:0000236 MAT:0000138 MESH:D004423 MIAA:0000138 OpenCyc:Mx4rvViXS5wpEbGdrcN5Y29ycA OpenCyc:Mx4rvVjL05wpEbGdrcN5Y29ycA Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. The organ of hearing and of equilibrium. [TFD][VHOG] UBERON:0001690 UMLS:C0013443 UMLS:C0521421 VHOG:0000330 XAO:0000189 auditory apparatus auricular auris galen:Ear uberon nail A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]. A primate's nail consists of the unguis alone; the subunguis has disappeared BTO:0001719 CALOHA:TS-2034 EFO:0000956 EMAPA:35580 EV:0100159 FMA:54326 GAID:1320 MA:0002703 MAT:0000158 MESH:D009262 MIAA:0000158 OpenCyc:Mx4rvVjJv5wpEbGdrcN5Y29ycA The nails of humans and the claws are moth are highly similar. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse [PMC3579226] UBERON:0001705 UMLS:C0027342 Use this class for both the nails of primates and the homologous claws of mammals such as mouse. VHOG:0001361 XAO:0003103 claw galen:Nail nail/claw talon uberon cranial ganglion BTO:0000106 EFO:0000902 EMAPA:16659 FMA:54502 Ganglion which is located in the head.[TAO] MA:0000213 MA:0000214 MAT:0000200 MIAA:0000200 TAO:0000013 UBERON:0001714 UBERON:0003213 UBERON:0026601 VHOG:0000076 XAO:0000027 ZFA:0000013 cranial ganglia cranial ganglion cranial ganglion part of peripheral nervous system cranial ganglion/nerve cranial nerve ganglion cranial neural ganglion cranial neural tree organ ganglion ganglion of cranial nerve ganglion of cranial neural tree organ head ganglion presumptive cranial ganglia the groups of nerve cell bodies associated with the twelve cranial nerves uberon spinal nerve AAO:0011101 Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG] BAMS:spin BTO:0000870 EHDAA2:0001898 EMAPA:16989 FMA:5858 GAID:841 MA:0000233 MESH:D013127 OpenCyc:Mx4rwK_iFJwpEbGdrcN5Y29ycA UBERON:0001780 UMLS:C0037941 VHOG:0000824 XAO:0003101 backbone nerve nerve of backbone nerve of spinal column nerve of spine nerve of vertebral column nervi spinales spinal column nerve spinal nerve tree spinal nerves spine nerve the any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified] uberon vertebral column nerve cranial nerve AAO:0000108 BAMS:cran BTO:0001104 Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. EHDAA2:0000323 EMAPA:17264 FMA:5865 GAID:802 HBA:9299 MA:0000215 MBA:967 MESH:D003391 OpenCyc:Mx4rvWvJVpwpEbGdrcN5Y29ycA See https://github.com/obophenotype/mouse-anatomy-ontology/issues/6 TAO:0000641 Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO] UBERON:0001785 UMLS:C0010268 UMLS:C1269897 VHOG:0000279 We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG] XAO:0000429 XAO:0003089 ZFA:0000641 classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN. cranial nerves cranial neural tree organ nervus cranialis uberon forebrain AAO:0010147 BAMS:FB BAMS:Forebrain BTO:0000478 CALOHA:TS-0380 DHBA:10156 DMBA:15566 EFO:0000909 EHDAA2:0000556 EHDAA:3470 EMAPA:16895 FB FMA:61992 In craniate embryos, neural expression of Distal-less-related genes is exclusively in the forebrain (...). Because the major neural expression domain of amphioxus AmphiDll is in the anterior three-fourths of the cerebral vesicle, we suggest that this region of the neural tube is homologous to parts of the craniate forebrain. This conclusion is strongly supported by three-dimensional, computer-assisted reconstruction of the neural tube of amphioxus based on serial transmission electron microscopy. At the neuroanatomical level, a number of detailed homologies are indicated between the anterior three-fourths of the amphioxus cerebral vesicle and the diencephalic region of the craniate forebrain. If one assumes that the amphioxus condition fairly represents the nervous system of the proximate ancestor of the craniates, one can suggest that they evolved from a creature that had the beginnings of a forebrain.[well established][VHOG] MA:0000170 MAT:0000105 MESH:D016548 MIAA:0000105 Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO] TAO:0000109 The most anterior region the brain including both the telencephalon and diencephalon. The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO] UBERON:0001890 UMLS:C0085140 VHOG:0000383 XAO:0000011 ZFA:0000109 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27 prosencephalic prosencephalon relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO] uberon midbrain AAO:0010149 BAMS:MES BM:MB BTO:0000138 CALOHA:TS-0630 DHBA:10648 DMBA:16649 EFO:0000919 EHDAA2:0001162 EHDAA:3694 EMAPA:16974 EV:0100242 FMA:61993 Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] HBA:9001 MA:0000207 MAT:0000106 MB MBA:313 MESH:D008636 MIAA:0000106 Middle part of the brain composed of the optic tectum and penducular region.[AAO] OpenCyc:Mx4rvsBUqpwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0001104 TAO:0000128 The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO] The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. UBERON:0001891 UMLS:C0025462 VHOG:0000069 XAO:0000014 ZFA:0000128 developmental relationships need revised http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=462 mesencephalic mesencephalon part of brainstem in ABA - we reject this in favor of ISBN10:0471888893 which has an implicit overlaps relationships uberon telencephalon AAO:0010479 BAMS:CB BAMS:CH BAMS:IV BAMS:Tel BM:Tel BTO:0000239 CALOHA:TS-1018 DHBA:10158 EFO:0000912 EHDAA2:0001982 EMAPA:16652 EMAPA:16910 EV:0100165 FMA:62000 From an evolutionary standpoint, the telencephalon is the most recent brain structure: the amphioxus does not have this structure as a morphological entity. Overt telencephalon is present in the hagfish and lamprey to receive numerous input fibers from various parts of the CNS, similar to gnathostomes.[well established][VHOG] GAID:621 HBA:4007 In mammals the cortex covers almost the whole of the cerebral hemispheres. In ray-finned fishes the inner surfaces of the lateral and ventral regions of the cerebrum bulge up into the ventricles. In the amniotes, the cerebrum becomes increasingly large and complex. In reptiles, the paleopallium is much larger than in amphibians, and its growth has pushed the basal nuclei into the central regions of the cerebrum. In the most primitive living vertebrates, the hagfishes and lampreys, the cerebrum is a relatively simple structure receiving nerve impulses from the olfactory bulb. MA:0000183 MAT:0000421 MBA:567 MESH:D013687 MIAA:0000421 Organ component of neuraxis that has as its parts the cerebral cortex, cerebral white matter, basal ganglia, septum and fornix, as well as subcortical gray and white matter structures[FMA:62000]. PBA:128011350 Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres. Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.[AAO] TAO:0000079 The anterior and dorsal forebrain neuromere, includes the olfactory bulb. Kimmel et al, 1995.[TAO] The cerebrum of birds has evolved along different lines to that of mammals, although they are similarly enlarged, by comparison with reptiles. However, this enlargement is largely due to the basal ganglia, with the other areas remaining relatively primitive in structure. UBERON:0001893 UMLS:C0039452 VHOG:0000283 XAO:0000012 ZFA:0000079 cerebral cerebrum dolphins are the only species (other than humans) to have cerebra accounting for as much as 2 percent of their body weight. endbrain http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 relationship loss: develops_from presumptive telencephalon (TAO:0000571)[TAO] supratentorial region telenencephalic uberon metencephalon Anterior part of the hindbrain ventral to the cerebellum[NIFSTD:birnlex_965]. BAMS:Met BTO:0000673 CALOHA:TS-2029 DHBA:10655 EHDAA2:0001149 EHDAA:5498 EMAPA:17071 FMA:62003 GAID:594 HBA:4833 MA:0000197 MESH:D020540 Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. The anterior of two brain vesicles formed by specialization of the rhombencephalon in the developing embryo. It gives rise to cerebellum and pons. [TFD][VHOG] The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] UBERON:0001895 UMLS:C0376353 UMLS:C1516904 VHOG:0000741 epencephalon epencephalon-2 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=543 the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. uberon medulla oblongata AAO:0010486 BAMS:MY BAMS:Md BM:Me BTO:0000041 CALOHA:TS-0607 Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG] DMBA:17352 EFO:0000924 EHDAA2:0001088 EHDAA:7588 EMAPA:17550 EV:0100275 FMA:62004 GAID:590 MA:0000206 MAT:0000111 MAT:0000367 MBA:354 MESH:D008526 MIAA:0000111 OpenCyc:Mx4rvVjxSJwpEbGdrcN5Y29ycA OpenCyc:Mx4rwCqnXJwpEbGdrcN5Y29ycA Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO] TAO:0000545 The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] UBERON:0001896 UMLS:C0025148 UMLS:C1269575 VHOG:0000181 XAO:0003100 ZFA:0000545 bulb bulbus http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=698 medulla medulla oblonzata metepencephalon uberon midbrain tegmentum 'tegmentum' is used generically for the ventral part of the brainstem (ISBN10:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum BAMS:MTg BTO:0003388 DHBA:12195 EFO:0000921 EHDAA2:0004475 EMAPA:18215 FMA:62393 HBA:9002 MA:0000212 MAT:0000452 MTg TAO:0000160 Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] UBERON:0001943 UMLS:C0039441 VHOG:0001367 Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN10:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. XAO:0004271 ZFA:0000160 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=491 mesencephalic tegmentum tegmentum tegmentum mesencephali tegmentum mesencephalicum tegmentum of midbrain uberon blood plasma BTO:0000131 CALOHA:TS-0800 EFO:0001905 EMAPA:35690 FMA:62970 GAID:1178 MA:0002501 MAT:0000052 MESH:D010949 MIAA:0000052 OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw The liquid component of blood, in which erythrocytes are suspended. UBERON:0001969 UMLS:C0032105 blood plasm plasma portion of blood plasma portion of plasma uberon blood vessel A vessel through which blood circulates in the body. AAO:0011004 AEO:0000207 Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG] Any of the vessels through which blood circulates in the body.[AAO] BTO:0001102 CALOHA:TS-0080 EFO:0000817 EHDAA2:0003252 EHDAA:240 EMAPA:32743 EMAPA:35993 FMA:50722 FMA:63183 FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX GAID:169 MA:0000060 MAT:0000393 MESH:D001808 OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA TAO:0002137 The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] UBERON:0001981 UMLS:C0005847 VHOG:0001250 XAO:0001011 ZFA:0005314 annelids have blood vessels, but this class is not applicable to annelids. consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus region of vascular tree organ uberon vas sanguineum vascular element vascular tree organ region gray matter A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. AEO:0001012 EHDAA2:0003136 EHDAA2_RETIRED:0004658 FMA:67242 HBA:4006 MA:0001112 Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO] OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA TAO:0002197 UBERON:0002020 UMLS:C0018220 VHOG:0001768 ZFA:0001681 gray mater gray matter gray matter of neuraxis grey matter grey matter of neuraxis grey substance grisea neuronal grey matter substantia grisea uberon hindbrain AAO:0010150 BAMS:HB BTO:0000672 CALOHA:TS-0457 DHBA:10653 DMBA:16808 EFO:0000923 EHDAA2:0000746 EHDAA:3514 EHDAA:6487 EMAPA:16916 FMA:67687 Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] MA:0000195 MAT:0000107 MBA:1065 MESH:D012249 MIAA:0000107 Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO] TAO:0000029 The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO] The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. UBERON:0002028 UMLS:C0035507 UMLS:C1522180 VHOG:0000070 XAO:0000015 ZFA:0000029 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=540 in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO] rhombencephalic rhombencephalon uberon striated muscle tissue AAO:0010762 AEO:0000140 CALOHA:TS-2047 EHDAA2:0003140 EMAPA:36390 FMA:67905 MA:0002438 Muscle tissue that contains fibers that are divided by transverse bands into striations. OpenCyc:Mx4rwAoze5wpEbGdrcN5Y29ycA UBERON:0002036 UMLS:C1331262 Voluntary muscle tissue arranged in bundles of fibers.[AAO] WBbt:0005779 galen:StriatedMuscle striated muscle uberon cerebellum AAO:0010485 BAMS:CB BAMS:Cb BM:CB BTO:0000232 CALOHA:TS-0125 DHBA:10656 Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO] EFO:0000327 EHDAA2:0000232 EMAPA:17787 EV:0100293 FMA:67944 GAID:595 HBA:4696 However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG] MA:0000198 MAT:0000110 MBA:512 MESH:D002531 MIAA:0000110 OpenCyc:Mx4rvl1eipwpEbGdrcN5Y29ycA Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]. Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO] TAO:0000100 The absence of a cerebellum in hagfishes and lampreys appears to be the only exception [to the rule that vertebrates possess the same number of brain divisions]. Both hagfishes and lampreys do possess a thin band of cells located medial to the lateral line centers of the medulla (Ronan and Northcutt, 1998), which has been interpreted as a primitive cerebellum (Larsell, 1967), but more recent experimental studies (Kishida et al., 1987; Weigle and Northcutt, 1998) fail to support Larsell's claim[http://icb.oxfordjournals.org/content/42/4/743.full] UBERON:0002037 UMLS:C0007765 UMLS:C1268981 VHOG:0000024 XAO:0003098 ZFA:0000100 almost all AOs agree that the cerebellum is part of the hindbrain (sometimes specifically part of the metencephalon, which, when present, is part of the hindbrain). However, ABA has cerebellum and brain stem as partof siblings, with the hindbrain part of the brainstem cerebellar corpus cerebelli epencephalon-1 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=643 infratentorial region parencephalon uberon lung AAO:0000275 AAO:0010567 BTO:0000763 CALOHA:TS-0568 EFO:0000934 EHDAA2:0001042 EHDAA:1554 EHDAA:2205 EMAPA:16728 EV:0100042 Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO] FMA:7195 GAID:345 Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG] MA:0000415 MAT:0000135 MESH:D008168 MIAA:0000135 OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA Respiration organ that develops as an oupocketing of the esophagus. Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] UBERON:0002048 UMLS:C0024109 VHOG:0000310 XAO:0000119 galen:Lung pulmo pulmonary respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi uberon vasculature An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. BTO:0003718 FMA:69050 TAO:0005249 UBERON:0002049 ZFA:0005249 see also: vascular system. Consider merging? uberon vascular vascular network embryonic structure AAO:0000138 Anatomical structure that is part of an embryo. Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO] Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO] Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO] BILA:0000034 BTO:0000174 CALOHA:TS-2110 EFO:0000461 FBbt:00004208 FMA:69067 GAID:407 MESH:D004628 RETIRED_EHDAA2:0003169 TAO:0001105 UBERON:0002050 UMLS:C0013948 VSAO:0000178 XAO:0003042 ZFA:0001105 developing embryonic structure developing structure embryonale Struktur embryonic anatomical structure embryonic structures in FMA embryo is_a embryonic structure uberon dermis A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] AAO:0000128 BTO:0000294 CALOHA:TS-2076 Consider adding a layer-of-skin grouping class for all skin layers EFO:0000953 EMAPA:17527 EV:0100154 FMA:70323 GAID:1321 MA:0000152 MAT:0000153 MESH:D020405 MIAA:0000153 TAO:0001119 The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. UBERON:0002067 UMLS:C0011646 VHOG:0000108 When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] XAO:0000217 ZFA:0001119 corium cutis dermal uberon vertebrate dermis hypodermis A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO] A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]. BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument. BTO:0001314 BTO:0004525 CALOHA:TS-2366 FMA:70544 FMA:9630 GAID:929 Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA]. MESH:A.10.165.887 Note that this class combines superficial fascia and hypodermis in FMA. Note also BTO has 'subcutis' TAO:0001136 UBERON:0002072 UBERON:FMA_70544-MIAA_0000418-ZFA_0000117-ZFA_0001136 UMLS:C0278403 ZFA:0001136 http://upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Skin.svg/200px-Skin.svg.png hypoderm hypodermal ncithesaurus:Superficial_Fascia sub-tegumental tissue subcutaneous subcutaneous tissue subcutaneus subcutis subtegumental tissue superficial fascia superficial fascia tela subcutanea tela subcutanea uberon vertebrate hypodermis postcranial axial skeleton AAO:0000034 EFO:0000942 EHDAA2:0000161 EHDAA:5049 EMAPA:17214 FMA:71221 MA:0002986 MAT:0000148 MIAA:0000148 Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO] TAO:0000317 The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG] The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO] The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO] The post-cranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. UBERON:0002090 VHOG:0000317 VSAO:0000093 XAO:0003073 ZFA:0000317 axial skeleton http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton post-cranial axial skeleton previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. uberon appendicular skeleton AAO:0000747 EFO:0000951 EMAPA:32729 FMA:71222 MA:0000290 MAT:0000278 MIAA:0000278 Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO] Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO] Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO] UBERON:0002091 UMLS:C0222646 VHOG:0001666 VSAO:0000076 XAO:0003166 appendicular skeleton entire appendicular skeleton https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved. paired fin skeleton skeleton appendiculare uberon skin of body BTO:0001253 CALOHA:TS-0934 EFO:0000962 EHDAA2:0001844 EMAPA:17525 FMA:7163 MA uses the term skin to refer to what is called here: zone of skin MESH:A.17.815 MESH:D012867 MFMO:0000099 Nonparenchymatous organ that consists of the dermis and epidermis. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body. Examples: There is only one skin[FMA]. Surface structure that consists of the external membranous integument of the animal. Note that FMA uses 'skin' for the entire organ. XAO seems consistent. MA seems to use it analagously to zone of skin OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA SCTID:181469002 The organ covering the body that consists of the dermis and epidermis. UBERON:0002097 UBERON:FMA_7163-MA_0000151-MIAA_0000284-XAO_0000023 UMLS:C1123023 XAO:0000023 consider 'integumentary system' for invertebrates entire integument entire skin galen:Skin http://upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Skin.svg/200px-Skin.svg.png integument integumental organ ncithesaurus:Skin pelt skin skin organ uberon trunk AAO:0010339 BILA:0000116 BTO:0001493 CALOHA:TS-1071 EFO:0000966 EMAPA:31857 FMA:7181 MA:0000004 MAT:0000296 MIAA:0000296 OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO] Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO] Rumpf TAO:0001115 UBERON:0002100 UMLS:C0460005 XAO:0000054 XAO:0003025 ZFA:0001115 galen:Trunk thoracolumbar region torso trunk region uberon limb A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts. AAO:0010336 AEO:0000172 CALOHA:TS-0552 EFO:0000876 EHDAA2:0003172 EHDAA:1697 EHDAA:8273 EMAPA:16405 FMA:24875 GAID:36 MA:0000007 MAT:0000090 MIAA:0000090 Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG] OpenCyc:Mx4rvn1uSZwpEbGdrcN5Y29ycA Organism subdivision that has as its parts the jointed appendages used for locomotion and manipulation.[AAO] UBERON:0002101 UMLS:C0015385 VHOG:0000336 VSAO:0000121 XAO:0003027 extremities extremity flipper free limb galen:Extremity limb sensu vertebrata pentadactyl limb tetrapod limb uberon vestibulo-auditory system AAO:0000631 EMAPA:36002 FMA:78500 Sensory system responsible for the perception of spatial orientation and auditory stimuli. TAO:0001138 The sensory system used for balance and hearing.[AAO] UBERON:0002105 XAO:0003195 ZFA:0001138 auditory organ system auditory system auditory/vestibular system uberon vestibuloauditory system vestibuloauditory system right lung EHDAA2:0001730 EHDAA:4969 EMAPA:17661 FMA:7309 Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA] Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] MA:0000426 OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA UBERON:0002167 UMLS:C0225706 VHOG:0000301 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern uberon left lung EHDAA2:0000943 EHDAA:4947 EMAPA:17653 FMA:7310 Lung which consists of the left upper lobe and left lower lobe.[FMA] Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] MA:0000425 OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA UBERON:0002168 UMLS:C0225730 VHOG:0000618 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern uberon hemolymphoid system Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. CALOHA:TS-2018 EHDAA2:0004615 EMAPA:18765 FMA:74562 MA:0000013 UBERON:0002193 haemolymphoid system hematolymphoid system lymphomyeloid complex uberon integument AAO:0000239 Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO] BTO:0000634 FMA:74657 Hautsystem@de Surface structure that is the outer protective covering of the body.[VSAO] TAO:0000368 The dermis, epidermis and hypodermis. The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO] UBERON:0002199 VSAO:0000029 ZFA:0000368 dermal system dermis plus epidermis plus hypodermis dermoid system galen:Integument in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition. integumental integumentary integumentum commune skin skin and subcutaneous tissue skin plus hypodermis tegument the integument uberon vertebrate integument musculoskeletal system AAO:0010546 Anatomical system that consists of the muscular and skeletal systems. Anatomical system that provides locomotion and physical support to the organism.[AAO] CALOHA:TS-1311 EMAPA:32714 EV:0100139 FMA:7482 GAID:98 MA:0002418 MESH:D009141 OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG] UBERON:0002204 UMLS:C0026860 VHOG:0001275 VSAO:0000031 XAO:0000168 musculo-skeletal system musculoskeletal uberon synovial joint AEO:0000183 CALOHA:TS-2138 EHDAA2:0003183 FMA:7501 Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO] Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA] MA:0000322 OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA TAO:0005153 UBERON:0002217 ZFA:0005153 articulatio synoviale diarthrodial joints diarthroses diarthrosis diarthrosis joint galen:SynovialJoint uberon thoracic cavity EMAPA:36497 FMA:7565 GAID:93 In many species, the diaphragm separates thoracic and abdominal cavities MA:0000032 MESH:A01.911.800 OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. UBERON:0002224 UMLS:C0230139 cavitas thoracis cavity of chest cavity of thorax chest cavity pectoral cavity space of thoracic compartment thoracic lumen uberon spinal cord (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] AAO:0010151 BAMS:SP BAMS:Spinal BM:SpC BTO:0001279 CALOHA:TS-0953 DHBA:12890 DMBA:17651 EFO:0000110 EHDAA2:0001255 EHDAA:2863 EMAPA:17577 EV:0100316 FMA:7647 GAID:695 MA:0000216 MAT:0000183 MESH:D013116 MIAA:0000183 OpenCyc:Mx4rvVjjk5wpEbGdrcN5Y29ycA Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO) Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO] SpC TAO:0000075 TODO - add superclass to unify with VNC? UBERON:0002240 UMLS:C0037925 VHOG:0000601 XAO:0000020 ZFA:0000075 cerebro-cerebellar fissure cerebrocerebellar fissure fissura cerebro-cerebellaris fissura cerebrocerebellaris http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=22 medulla spinalis spinal cord structure spinal medulla uberon olfactory organ AAO:0010180 An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ. BTO:0001772 FBbt:00005158 FMA:77659 UBERON:0002268 VHOG:0000287 XAO:0000273 fma general anatomical term. xao has no subtypes (but Johnstons organ develops from this). An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint main olfactory organ olfactory neuroepithelium olfactory organ olfactory sense organ olfactory sensory organ organ olfactus organum olfactorium primary olfactory organ uberon brainstem 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN10:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). BAMS:BS BTO:0000146 CALOHA:TS-0093 EFO:0001962 EMAPA:32678 EV:0100241 FMA:79876 MA:0000169 MBA:343 MESH:D001933 Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO] Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707]. Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. TAO:0002156 UBERON:0002298 UMLS:C0006121 VHOG:0001457 ZFA:0001707 accessory medullary lamina of pallidum brain stem http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=236 lamella pallidi incompleta lamina medullaris accessoria lamina medullaris incompleta pallidi lamina pallidi incompleta the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP] truncus encephali truncus encephalicus uberon coelemic cavity lumen AEO:0000186 Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA]. BTO:0001707 EHDAA2:0000267 FBbt:00005060 FMA:85006 In mammals it forms the peritoneal, pleural, and pericardial cavities RETIRED_EHDAA2:0003186 TAO:0001438 The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]. UBERON:0000169 UBERON:0002323 UMLS:C0333343 ZFA:0001438 body cavity celom check the FMA placement here; ncit placement of body cavity here probably not correct coelom coelome coelomic cavity coelomic cavity lumen galen:BodyCavity hemocoel main body cavity space of body compartment uberon ventral body cavity notochord (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG] A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. AAO:0000327 Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO] BTO:0001768 CALOHA:TS-0690 EHDAA2:0001277 EHDAA:1241 EHDAA:6021 EMAPA:16191 EV:0100002 FMA:85521 GAID:1311 In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord. MAT:0000281 MESH:A16.254.610 Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO] Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO] TAO:0000135 The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] UBERON:0002328 UMLS:C0028439 VHOG:0000199 VSAO:0000032 XAO:0000055 ZFA:0000135 embryonic notocord notochorda notochordal notocord relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO] uberon somite (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG] AAO:0010569 AEO:0001015 BTO:0001558 EHDAA2:0003436 EHDAA:366 EHDAA:699 EMAPA:31169 FMA:85522 GAID:1306 MAT:0000068 MESH:A16.254.425.660.750 MIAA:0000068 Post-cranial axial segments which form sclerotome and dermomyotome.[AAO] Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. TAO:0000155 UBERON:0002329 UMLS:C0376449 Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO] VHOG:0000191 When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] XAO:0000058 ZFA:0000155 currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk epimere epimere mesoderm epithelial somite mesodermal cluster relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO] relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO] relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO] somites somitic somitic mesoderm somitus uberon exocrine system Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. CALOHA:TS-2057 EHDAA2:0002225 EMAPA:35329 FMA:85539 MA:0002411 UBERON:0002330 UMLS:C1516995 WikipediaCategory:Exocrine_system exocrine glandular system uberon neural crest A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO] A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831] AAO:0010578 BTO:0001764 CALOHA:TS-0676 EHDAA2:0004419 EMAPA:32737 FMA:86666 GAID:1310 Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. MAT:0000066 MESH:A16.254.600 MIAA:0000066 Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO] NC TAO:0000045 UBERON:0002342 UMLS:C0027789 VHOG:0000057 We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG] XAO:0000048 ZFA:0000045 consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). crista neuralis neural crest material uberon neurectoderm (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG] AAO:0011074 BILA:0000039 CALOHA:TS-1212 EHDAA2:0001248 EHDAA:1498 EHDAA:255 EMAPA:16073 EV:0100004 Embryonic ectoderm that gives rise to nervous tissue. FBbt:00001061 FMA:87657 MAT:0000176 MIAA:0000176 TAO:0001120 UBERON:0002346 UMLS:C1518271 VHOG:0000150 XAO:0000042 ZFA:0001120 epithelium tubi neuralis; neuroectoderma neuaral ectoderm neural ectoderm neurectodermal neuroectoderm presumptive central nervous system uberon ventral neurogenic region we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here exocrine gland A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas AEO:0000097 BTO:0000765 CALOHA:TS-2012 Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses EHDAA2:0003097 EMAPA:35327 FMA:9596 GAID:34 MA:0002564 MESH:D005088 UBERON:0002365 UMLS:C0015282 ducted gland glandula exocrina uberon connective tissue AAO:0000098 BTO:0000421 Bindegewebe CALOHA:TS-2009 EFO:0000952 EMAPA:35251 FMA:9640 GAID:100 MA also has set of connective tissues MA:0000011 MAT:0000301 MESH:D003238 MIAA:0000301 One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO] OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO] TAO:0001641 Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO] UBERON:0002384 UMLS:C0009780 VSAO:0000017 XAO:0001017 ZFA:0001632 galen:ConnectiveTissue portion of connective tissue textus connectivus uberon muscle tissue AAO:0000306 AEO:0000122 CALOHA:TS-0642 EHDAA2:0003122 EMAPA:32715 FMA:9641 MA:0002437 MESH:D009132 Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] UBERON:0002385 UMLS:C2328219 Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. galen:MuscleTissue muscular tissue portion of muscle tissue textus muscularis uberon hematopoietic system AAO:0011002 Anatomical system that consists of the blood and blood forming tissues.[AAO] Anatomical system that is involved in the production of hematopoietic cells. BTO:0000570 Blutbildungssystem CALOHA:TS-0449 EFO:0000798 EMAPA:35402 EV:0100045 FMA:9667 GAID:1008 In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes MA:0002434 MAT:0000022 MESH:D006413 MIAA:0000022 TAO:0005023 UBERON:0002390 UMLS:C0018957 VHOG:0001624 XAO:0000122 ZFA:0005023 Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG] haematological system haematopoietic system haemopoietic system hematological system hematolymphoid system hematopoietic hemopoietic system organa haemopoietica uberon immune system AAO:0011003 Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. BILA:0000104 FMA:9825 GAID:328 MA:0002711 MESH:D007107 OpenCyc:Mx4rvWNkm5wpEbGdrcN5Y29ycA TAO:0001159 The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG] UBERON:0002405 UMLS:C0020962 VHOG:0001247 XAO:0003152 ZFA:0001159 uberon integumental system (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] AEO:0000154 BILA:0000118 CALOHA:TS-1299 CARO:0002001 Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. EFO:0000807 EHDAA2:0000836 EHDAA2_RETIRED:0003154 EHDAA:6520 EMAPA:17524 EV:0100151 FBbt:00004969 FMA:72979 HAO:0000421 MA:0000014 MAT:0000033 MESH:D034582 MIAA:0000033 TADS:0000108 UBERON:0002416 UBERON:0007029 UMLS:C0037267 VHOG:0000403 XAO:0000176 body surface dermal system external covering of organism galen:Surface integumentary system integumentum commune organism surface surface uberon abdominal segment of trunk EMAPA:35104 FMA:259211 MA:0000021 The abdominal segment of the torso. UBERON:0002417 abdomen/pelvis/perineum lower body lower trunk lumbar region uberon cartilage tissue A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO] AAO:0000060 AEO:0000087 BTO:0000206 EFO:0000949 EHDAA2:0003087 EMAPA:32730 EV:0100141 FMA:37377 GAID:99 MA:0000104 MAT:0000189 MESH:D002356 MIAA:0000189 OpenCyc:Mx4rvVjeOZwpEbGdrcN5Y29ycA Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG] Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO] Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO] TAO:0001501 UBERON:0002418 UMLS:C0007301 VHOG:0001207 VSAO:0000040 XAO:0000170 ZFA:0005622 cartilage cartilage tissue cartilages cartilaginous tissue chondrogenic tissue galen:Cartilage portion of cartilage tissue relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] uberon limb bone A bone that is part of a limb [Automatically generated definition]. EFO:0000945 MAT:0000151 MIAA:0000151 NCITA includes clavicle. MA:'limb bone' is actually a bone of limb or girdle UBERON:0002428 UMLS:C0582791 bone of extremity bone of limb free limb bone the formal definition is very inclusive, and includes sesamoids uberon autopod region BTO:0004359 EFO:0000877 EMAPA:32722 FMA:83015 MA:0002714 MAT:0000091 MIAA:0000091 Naming conventions for pod terms under discussion within phenoscape group; note that this refers to the limb segment, not just the skeleton. Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot UBERON:0002470 UMLS:C0687080 autopod autopodial element autopodial limb segment autopodial segment autopodium autopodium region distal free limb segment distal segment of free limb distal segment of limb manus/pes paw paw/hand/foot/hoof pod uberon zeugopod EFO:0000878 FMA:83016 MA:0002716 MAT:0000092 MIAA:0000092 The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus). There exists some controversy about which podial segments are present in some fishes, e.g. if the autopod is not newly evolved in tetrapods, there is a question as to which segments are actually present in basal vertebrate taxa.[PHENOSCAPE:curators] UBERON:0002471 epipodium middle free limb segment middle limb segment middle part of limb middle segment of free limb uberon zeugopod limb segment zeugopodial zeugopodial limb segment zeugopodium zygopod zygopodium stylopod EFO:0000879 FMA:83014 MA:0002717 MAT:0000093 MIAA:0000093 Naming conventions for pod terms under discussion within phenoscape group The proximal free limb segment. Includes as parts the stylopod skeleton. UBERON:0002472 propodium proximal free limb segment proximal part of limb proximal segment of free limb stylopodial stylopodial limb segment stylopodium uberon bone tissue CALOHA:TS-2011 EMAPA:35179 FMA:224804 MA:0002780 MESH:D001842 Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO] UBERON:0002481 UMLS:C0391978 VSAO:0000047 XAO:0004040 ZFA:0005621 bone calcium tissue galen:BoneTissue mineralized bone tissue osseous tissue osteogenic tissue portion of bone tissue see https://github.com/obophenotype/uberon/issues/27 uberon long bone BTO:0004256 EMAPA:35503 Endochondral_ossification is an essential process during the rudimentary formation of long bones, with the exception of the clavicle[Wikipedia:Endochondral_ossification]. The medial and and lateral ends undergo EO, the mid-portion is formed by a process with features of EO & IO (the process is shared by the mandible)[ISBN:9780397517251] FMA:7474 Long bone is a limb bone that is subcylindrical and has a shaft with periosteum separating the ends of the bones. Long bones are present only in the limbs[VSAO:wd]. MA:0002802 OpenCyc:Mx4rv6axr5wpEbGdrcN5Y29ycA UBERON:0002495 UMLS:C0222647 galen:LongBone os longum uberon endochondral bone AAO:0010776 AEO:0000083 BTO:0002157 EHDAA2:0003083 FMA:24321 Replacement bone that forms within cartilage. Replacement bone that forms within cartilage.[VSAO] TAO:0001591 UBERON:0002513 VSAO:0000145 XAO:0004018 ZFA:0001591 cartilaginous bone endochondral bones https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern ossified chondrogenic bone placement in this class to be inferred some structures, e.g. in ZFA are both intramembrane and endochondral uberon limb segment A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles. FMA has both limb segment and free limb segment, the former includes the girdles. Note that MA uses the term more generally and includes A,S,Z,S+Z(arm/leg), whereas FMA is just A,S,Z FMA:241863 MA:0002889 TODO - align this with the CARO2 class 'appendage segment'; note the FMA class does not appear to require repetition UBERON:0002529 UMLS:C1268195 extremity part free limb segment limb region region of limb segment of limb subdivision of limb uberon gland AAO:0000212 AEO:0000096 BTO:0000522 Druese EFO:0000797 EHDAA2:0003096 EHDAA:2161 EHDAA:4475 EHDAA:6522 EMAPA:18425 FBbt:00100317 FMA:7146 FMA:86294 HAO:0000375 MA:0003038 MAT:0000021 MIAA:0000021 OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA UBERON:0002530 UBERON:MIAA_0000021 UMLS:C1285092 WikipediaCategory:Glands an organ that functions as a secretory or excretory organ galen:Gland glandula glandular glandular organ uberon paired fin bud An outgrowth on the lateral trunk of the embryo that develops into a paired fin. The fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. EFO:0003468 Embryonic surface structure that develops into a paired fin.[ZFA] MAT:0000062 MIAA:0000062 TAO:0001383 UBERON:0002531 VSAO:0000179 ZFA:0001383 fin bud fin buds uberon epiblast (generic) BTO:0004593 FMA:296704 In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA] In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG] MAT:0000067 MIAA:0000067 MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class UBERON:0002532 VHOG:0000243 blastocyst ectoblast epiblast epiblastus primitive ectoderm uberon paired fin Fin that is one of a pair located ventrally on the organism. TAO:0002278 UBERON:0002534 VSAO:0000111 ZFA:0005596 artioptérygie@fr nageoire paire@fr pelvic/pectoral fin uberon digit A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans). AAO:0011126 EFO:0000881 EMAPA:32725 FMA:85518 MA:0000690 MAT:0000285 MIAA:0000285 OpenCyc:Mx4rvzLD_ZwpEbGdrcN5Y29ycA Our reinterpretation of the distal fin endoskeleton of Panderichthys removes the final piece of evidence supporting the formerly popular hypothesis that tetrapod digits are wholly new structures without homologues in sarcopterygian fish fins. This hypothesis, which was based partly on the complete absence of plausible digit homologues in Panderichthys (then the closest known relative of tetrapods), has already been called into question by the discovery of digit-like radials in Tiktaalik and the fact that Hox gene expression patterns closely resembling those associated with digit formation in tetrapods occur in the distal fin skeletons of paddlefish and Australian lungfish. Our new data show that Panderichthys is not an anomaly: like Tiktaalik and other fish members of the Tetrapodomorpha, it has distal radials that can be interpreted as digit homologues.[well established][VHOG] UBERON:0002544 UMLS:C0582802 VHOG:0000944 XAO:0003032 acropodial unit digit (phalangeal portion) plus soft tissue digital galen:Digit limb digit this class represents the entire organism subdivision encompassing soft tissue as well as the underlying skeletal framework. The class represents the phalangeal part only - historically the term 'digit' has also been used to represent the unit consisting of a series of phalanges together with a metapodial bone. We may in future relabel this class to avoid confusion with this concept, but the class will continue to represent the phalangeal portion uberon cranial placode AAO:0010466 Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons EFO:0001650 Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. MAT:0000369 MIAA:0000369 The term placode or placodes also applies to developing organs such as teeth, mammary glands, hair follicles, feathers and scales. We include a separate parent class for this. UBERON:0002546 XAO:0000305 cranial placodes placode to avoid confusion, we include neurogenic placode as a subclass. Do not merge. uberon anatomical cavity Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. FMA:67552 MA:0002447 UBERON:0002553 cavity galen:Cavity uberon regional part of brain Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. FMA:55676 UBERON:0002616 UMLS:C0445620 anatomical structure of brain biological structure of brain brain anatomical structure brain biological structure brain part neuraxis segment neuroanatomical region segment of brain uberon olfactory placode A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity. AAO:0011076 EFO:0003420 EHDAA2:0001232 EHDAA:1504 EMAPA:16543 FMA:293971 Olfactory placodes are the only ectodermal placodes to produce glia, a cell type typically derived from neural crest // Note that NBK53171 classifies this as non-neurogenic TAO:0000048 UBERON:0003050 VHOG:0000186 We conclude this section by listing some of the many synapomorphies of craniates, including (...) (2) neurogenic placodes (...).[well established][VHOG] XAO:0000005 ZFA:0000048 nasal I placode nasal placode olfactory placodes placoda nasalis placoda olfactoria uberon midbrain-hindbrain boundary AAO:0011064 DMBA:16810 EHDAA2:0004395 EHDAA:5789 EMAPA:32857 Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG] MHB TAO:0000042 The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. UBERON:0003052 VHOG:0000649 XAO:0000016 ZFA:0000042 consider adding class for organizer. Consider adding separate class for isthmus as a structure isthmic organizer territory isthmo-cerebellar region isthmus isthmus/MHB mid-hindbrain boundary mid-hindbrain junction midbrain hindbrain boundary uberon periderm A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. EHDAA2:0001846 EHDAA:6538 EVL FMA:295662 In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP] In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html) TAO:0001185 The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO] UBERON:0003055 UMLS:C1518973 VHOG:0001680 XAO:0000029 ZFA:0001185 epidermis epithelial layer epidermis outer layer epitrichium periderm relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO] skin periderm uberon pre-chordal neural plate (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011084 TAO:0007016 The portion of neural plate anterior to the mid-hindbrain junction. UBERON:0003056 VHOG:0001200 XAO:0000045 ZFA:0007016 anterior neural plate uberon chordal neural plate (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] TAO:0007017 The portion of neural plate posterior to the mid-hindbrain junction. UBERON:0003057 VHOG:0001201 XAO:0000046 ZFA:0007017 posterior neural plate uberon presomitic mesoderm AAO:0011086 EFO:0001982 EMAPA:16189 EMAPA:16752 It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] PSM TAO:0000279 UBERON:0003059 Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] VHOG:0000559 XAO:0000057 ZFA:0000279 presumptive somite mesoderm segmental plate somitogenic mesoderm somitomeric mesoderm uberon unsegmented mesenchyme unsegmented paraxial mesoderm blood island AAO:0011006 Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. EFO:0003489 EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac EHDAA:207 Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO] Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO] Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG] TAO:0000094 TE:E5.11.2.0.0.0.4 UBERON:0003061 UMLS:C1511224 VBI VHOG:0000085 XAO:0000067 ZFA:0000094 blood islands caudal hematopoietic tissue posterior ICM posterior blood island relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO] uberon ventral blood island ventral lateral plate mesoderm axial mesoderm AAO:0011017 EFO:0003647 TAO:0001204 The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] UBERON:0003068 VHOG:0000107 XAO:0000205 ZFA:0001204 chordamesoderm uberon neural plate (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] AAO:0011072 BTO:0001765 DHBA:10153 DMBA:15565 EHDAA:346 EHDAA:902 EMAPA:35593 FMA:293879 RETIRED_EHDAA2:0001252 TAO:0000132 The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] UBERON:0003075 UMLS:C0920623 VHOG:0000068 XAO:0000249 ZFA:0000132 lamina neuralis presumptive central nervous system uberon posterior neural tube (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011082 TAO:0007037 UBERON:0003076 VHOG:0001383 XAO:0000250 ZFA:0007037 uberon paraxial mesoderm AAO:0010568 EFO:0003515 EMAPA:16183 EMAPA:16751 FMA:293145 Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] TAO:0000255 The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO] UBERON:0003077 UMLS:C1284009 VHOG:0000114 XAO:0000259 ZFA:0000255 mesoderma paraxiale note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here) paraxial mesenchyme somitic mesoderm uberon anterior neural tube (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011012 TAO:0007038 TODO - add grouping class for the anterior end of the neural tube at all stages UBERON:0003080 VHOG:0001384 XAO:0000307 ZFA:0007038 uberon lateral plate mesoderm A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] AAO:0010574 EHDAA2:0000919 EHDAA:379 EMAPA:16179 FMA:293149 LPM Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO] Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. TAO:0000121 The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] UBERON:0003081 UBERON:0006258 UMLS:C1517749 VHOG:0000118 XAO:0000311 ZFA:0000121 lateral mesoderm lateral plate lateral plate mesenchyme mesoderma laminae lateralis subclass of mesoderm in ZFA. uberon myotome A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. AAO:0011067 AEO:0001018 BTO:0000742 EHDAA2_RETIRED:0003431 EHDAA:1721 EHDAA:1727 EHDAA:1733 EHDAA:1739 EMAPA:32841 FMA:295658 In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG] Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO] TAO:0001056 The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere. UBERON:0003082 UMLS:C1513802 VHOG:0001244 XAO:0000315 ZFA:0001056 muscle plate myomere myomeres myotome region myotomes myotomus uberon heart primordium AAO:0011044 BTO:0001887 Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. TAO:0000028 The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO] UBERON:0003084 UMLS:C1514450 XAO:0000336 ZFA:0000028 cardiac field fused heart primordium relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO] should probably be merged with heart rudiment. uberon sclerotome AAO:0010571 AEO:0000212 EHDAA2:0003439 EMAPA:31159 FMA:295652 Skeletogenic portion of somites.[AAO] TAO:0001080 The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] UBERON:0003089 UMLS:C0183176 VHOG:0000680 Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. XAO:0000397 ZFA:0001080 part_of somite in XAO sclerotomes sclerotomus uberon cranial neural crest AAO:0010580 Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO] CNC EFO:0003645 EHDAA2:0004420 EMAPA:16091 Neural crest that is part of the head.[TAO] TAO:0001194 UBERON:0003099 VHOG:0000063 We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] XAO:0001001 ZFA:0001194 cephalic neural crest cranial NCC population crista neuralis cranialis head NCC population head crest head neural crest neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. uberon surface structure AAO:0010337 AEO_RETIRED:0000010 Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. EHDAA2_RETIRED:0003010 Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] TAO:0000292 UBERON:0003102 VSAO:0000001 XAO:0003028 ZFA:0000292 anatomical surface feature galen:SurfaceRegion surface feature surface region surface structures uberon compound organ AAO:0010015 AEO:0000024 Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. BILA:0000024 CARO:0000024 EHDAA2:0003024 HAO:0000024 TADS:0000598 TAO:0000496 TGMA:0001837 UBERON:0003103 VHOG:0001723 XAO:0003041 ZFA:0000496 organ this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs uberon mesenchyme A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO] AAO:0010427 AEO:0000145 BTO:0001393 CALOHA:TS-0620 EHDAA2:0003145 EV:0100007 Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO] Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO]. TAO:0000393 UBERON:0003104 UMLS:C0162415 VHOG:0000170 XAO:0003046 ZFA:0000393 mesenchyma mesenchymal mesenchymal tissue mesenchyme tissue portion of mesenchymal tissue portion of mesenchyme tissue the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense uberon phalanx CALOHA:TS-2211 EMAPA:32614 Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits. FMA:321661 In primates such as humans and monkeys, the thumb and big toe have two phalanges, while the other fingers and toes consist of three MA:0000304 OpenCyc:Mx4rvolPZpwpEbGdrcN5Y29ycA UBERON:0003221 UMLS:C0222682 VSAO:0000199 digit long bone galen:Phalanx long bone of digit phalange phalangeal phalanges phalanx bone uberon endoderm of foregut An endoderm that is part of a foregut [Automatically generated definition]. EHDAA2:0004568 EHDAA:524 TODO - check UBERON:0003258 foregut endoderm uberon limb long bone A long bone that is part of a limb [Automatically generated definition]. EMAPA:35495 MA:0000298 UBERON:0003606 long bone of limb uberon limb joint Any joint that is part of a (free) limb. EMAPA:36501 FMA:321558 MA:0000691 Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses UBERON:0003657 galen:LimbJoint joint of limb joint of limb skeletal system skeletal limb joint uberon neural tissue AAO:0000325 AEO:0000123 EHDAA2:0003123 FMA definition includes vasculature FMA:9642 GAID:609 MESH:D009417 One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. UBERON:0003714 UMLS:C0027757 nerve tissue nervous tissue portion of neural tissue uberon metapodium bone A bone of the metapodial skeleton MA:0000301 UBERON:0003821 metacarpal or metatarsal bone metacarpal/metatarsal metacarpal/metatarsal bone metapodi bone metapodial bone metapodium bone uberon autopod joint A limb joint that is part of an autopod [Automatically generated definition]. EMAPA:35160 MA:0002715 UBERON:0003841 autopod joint of limb autopod limb joint distal free limb segment joint of limb distal free limb segment limb joint joint of limb of autopod joint of limb of distal free limb segment limb joint of autopod limb joint of distal free limb segment paw joint uberon neural tube lumen (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011073 An anatomical space that surrounded_by a neural tube. EHDAA2:0001269 EHDAA:2889 EHDAA:914 EMAPA:16167 EMAPA:16533 UBERON:0003842 UBERON:0005713 VHOG:0001119 XAO:0000252 cavity of neural tube central lumen lumen of neural tube neural lumen neural tube neural lumen neurocoel prosencoel uberon mesencephalic neural crest A neural crest that has_potential_to_developmentally_contribute_to a midbrain. EFO:0003591 EHDAA2:0001101 EHDAA:360 TAO:0000935 UBERON:0003849 VHOG:0000796 We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] ZFA:0000935 mesencephalic neural crest neural crest midbrain uberon telencephalon neural crest A neural crest that has_potential_to_developmentally_contribute_to a telencephalon. Cranial neural crest that is part of the telencephalon.[TAO] EFO:0003574 RETIRED_EHDAA2:0001991 TAO:0000812 UBERON:0003850 VHOG:0000799 We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] ZFA:0000812 neural crest telencephalon uberon rhombencephalon neural crest A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. Cranial neural crest that is part of the hindbrain.[TAO] EHDAA2:0001628 EHDAA:362 EMAPA:35747 TAO:0007063 UBERON:0003852 VHOG:0001210 We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] ZFA:0007063 neural crest hindbrain rhombencephalic neural crest rhombomere neural crest uberon spinal cord neural crest A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. EHDAA:696 EMAPA:16163 EMAPA:16529 EMAPA:16881 UBERON:0003853 VHOG:0001006 We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG] neural crest spinal cord spinal neural crest uberon presumptive ganglion A presumptive structure that has the potential to develop into a ganglion. UBERON:0003869 uberon future coelemic cavity lumen An anatomical cavity that has the potential to develop into a coelemic cavity lumen. UBERON:0003886 body cavity precursor uberon intraembryonic coelom (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] EHDAA:251 EMAPA:16088 The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom UBERON:0003887 UMLS:C1512940 VHOG:0000316 consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults somatic coelom uberon epithelial tube AEO:0000114 EHDAA2:0003114 Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. FBbt:00007474 UBERON:0003914 contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers epithelial or endothelial tube uberon digestive tract epithelium An epithelium that lines the lumen of the digestive tract. BTO:0000956 EHDAA2:0004567 EMAPA:32928 Epithelium lining the lumen of the gut.[TAO] MA:0003201 TAO:0005123 UBERON:0003929 UMLS:C0836205 XAO:0003200 ZFA:0005123 alimentary tract epithelium digestive tract epithelial tissue epithelial tissue of digestive tract epithelial tissue of gut epithelium of digestive tract epithelium of gut gastrodermis gut epithelial tissue gut epithelium uberon dermatome A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. AAO:0011028 AEO:0001017 EHDAA2_RETIRED:0003428 EHDAA:1719 EHDAA:1725 EHDAA:1731 EHDAA:1737 EMAPA:32838 FMA:295656 Not to be confused with 'dermatome segment of skin'. UBERON:0004016 UMLS:C0180383 XAO:0000220 cutis plate dermatomal mesenchyme epimere mesoderm mesenchyma dermatomiale uberon germinal neuroepithelium As the cells adjacent to the lumen continue to divide, the migrating cells form a second layer around the original neural tube. This layer becomes progressively thicker as more cells are added to it from the germinal neuroepithelium. This new layer is called the mantle (or intermediate) zone, and the germinal epithelium is now called the ventricular zone (and, later, the ependyma)[NCBIBook:NBK10047] The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells UBERON:0004022 germinal neuroepithelial layer germinal neuroepithelium original neural tube uberon neural tube ventricular layer EMAPA:17152 EMAPA:35362 EMAPA_RETIRED:16783 MA:0003193 The layer of undifferentiated, proliferating cells that line the neural tube lumen The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium UBERON:0004060 consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure ependymal layer neural tube ependymal layer neural tube ependymal zone neural tube ventricular germinal zone neural tube ventricular zone uberon neural tube mantle layer EMAPA:17148 EMAPA:35360 The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. UBERON:0004061 future brain marginal layer neural tube intermediate zone uberon neural tube marginal layer EMAPA:17151 The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter UBERON:0004062 brain marginal zone neural tube marginal zone uberon anatomical conduit 2 2 AEO:0000080 Any tube, opening or passage that connects two distinct anatomical spaces. EHDAA2:0003080 FMA has both conduit and conduit space. In EHDAA2 this is a surface feature FMA:242873 UBERON:0004111 foramen foramina opening ostia ostium uberon endoderm-derived structure An anatomical structure that develops (entirely or partially) from the endoderm. Grouping term for query purposes UBERON:0004119 uberon mesoderm-derived structure An anatomical structure that develops (entirely or partially) from the mesoderm. Grouping term for query purposes UBERON:0004120 uberon ectoderm-derived structure An anatomical structure that develops (entirely or partially) from the ectoderm. Grouping term for query purposes UBERON:0004121 uberon cardiogenic plate (In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG] EHDAA2:0000215 EMAPA:16106 TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO The first recognizable structure derived from the heart field UBERON:0004139 VHOG:0000975 cardiac crescent cardiogenic crescent heart rudiment myocardial plate uberon primary heart field A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. FHF PHF UBERON:0004140 XAO:0004185 first heart field heart field primary heart field this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] uberon heart tube AAO:0010411 An epithelial tube that will give rise to the mature heart. EFO:0003526 EMAPA:32685 TAO:0000360 UBERON:0004141 XAO:0000337 ZFA:0000360 embryonic heart tube endocardial heart tube endocardial tube the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. uberon cardiac chamber A cardiac chamber surrounds an enclosed cavity within the heart FMA:7095 OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw UBERON:0004151 chamber of heart generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus heart chamber uberon skeleton AEO:0000168 Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO] EHDAA2:0001843 EHDAA:5047 EMAPA:17213 FMA:23875 GAID:177 MA:0003006 MAT:0000032 MESH:D012863 MIAA:0000032 OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA UBERON:0004288 VSAO:0000026 XAO:0004053 galen:Skeleton https://github.com/obophenotype/uberon/wiki/The-skeletal-system set of all bones set of bones of body skeletal uberon dermomyotome AAO:0010572 AEO:0000214 EHDAA2:0003259 EMAPA:31109 Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] FMA:295654 Portion of somites that gives rise to dermis and muscles.[AAO] TAO:0001513 The bilaminar epithelium formed from the myotome and dermatome. Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG] UBERON:0004290 UMLS:C1511786 VHOG:0000676 ZFA:0001513 all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis. dermamyotome dermomyotomes uberon heart rudiment A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. TAO:0000115 The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO] UBERON:0004291 ZFA:0000115 heart cone rudimentary heart uberon distal phalanx AAO:0010676 Distal-most phalanx within a digit. EMAPA:35287 In human anatomy, the distal phalanges of the four fingers and toes articulate proximally with the intermediate phalanges at the distal interphalangeal joints (DIP); in the thumb and big toe, with only two phalanges, the distal phalanges articulate proximally with the proximal phalanges. The distal phalanges carry and shape nails and claws and are therefore occasionally referred to as the ungual phalanges. The distal phalanges are cone-shaped in most mammals, including most primates, but relatively wide and flat in humans. MA:0002914 UBERON:0004300 phalanx distalis phalanx distalis terminal phalanx uberon ungual phalanx middle phalanx A phalanx located between proximal and distal phalanges. AAO:0010677 EMAPA:35572 Intermediate phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones of the finger and toe which lie in the middle, between the two wrinkly joints. The thumb and big toe do not have intermediate phalanges. In most other vertebrates, they have a corresponding place in their limbs, whether they be paw, wing, hoof or fin MA:0002915 UBERON:0004301 consider using numbering system, and axioms to the effect that there is a single middle phalanx per finger in humans. This should perhaps be renamed 'intermediate phalanx', leaving the term middle phalanx open for the specific intermediate phalanx of a 3-phalanx digit in some groups such as whales, there are multiple intermediate phalanges intermediate phalanx medial phalanx penultimate phalanx phalanx 2 phalanx II uberon proximal phalanx 1 AAO:0010680 EMAPA:35716 MA:0002916 Proximal phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones at the base of a toe or finger, the prominent, knobby ends of which are often called the knuckles. In other vertebrates, proximal phalanges have a similar placement in the corresponding limbs, be they paw, wing or fin. In many species, they are the longest and thickest phalanx ('finger' bone) Proximal-most phalanx within a digit. UBERON:0004302 phalanx 1 phalanx I proximal-most phalanx uberon limb bud AAO:0010375 An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. BTO:0001640 EMAPA:35944 Early outgrowth of presumptive limb.[AAO] FMA:296780 GAID:1307 MESH:A16.254.462 UBERON:0004347 UMLS:C0282505 XAO:0003161 developmentally_induced_by Fgf10, capable of initiating limb forming interactions between endoderm and mesoderm gemmae membrorum limb buds limbbud uberon apical ectodermal ridge AAO:0010760 AER Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO] EMAPA:32744 Proliferative region that is part of the developing fin fold or fin.[TAO] TAO:0002146 The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold UBERON:0004356 UMLS:C1516037 XAO:0004121 ZFA:0001702 apical epidermal ridge crista ectodermalis apicalis maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. note that media, dorsal fins etc have AERs. relationship loss: subclass proliferative region (TAO:0000098)[TAO] uberon paired limb/fin bud An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] The tetrapod limb is derived from a posterior part of the fin endoskeleton of elasmobranchs and basal bony fish, the so-called metapterygium, a series of endoskeletal elements that is the first to form in the developing paired fins. (...) In addition, there is an independent endoskeletal element called the protopterygium that develops anterior to the metapterygium in many basal fishes (e.g., the bichir and sturgeon). Teleosts have lost the metapterygium whereas the sarcopterygians, on the other hand, have lost the protopterygium. Sarcopterygians thus develop all their endoskeletal structures from the metapterygium and consequently the tetrapod limb skeleton is derived from the metapterygium.[uncertain][VHOG] UBERON:0004357 VHOG:0001258 limb - fin bud paired appendage bud paired limb/fin bud uberon bone of free limb or fin A bone that is part of an appendage [Automatically generated definition]. UBERON:0004375 appendage bone bone of appendage bone of free segment of appendicular skeleton uberon skeleton of limb EHDAA2 considers hip and shoulder joints part of limb skeleton. EHDAA2:0002221 EMAPA:32702 Skeletal subdivision that is part of the limb.[VSAO] The collection of all skeletal elements in an individual limb. UBERON:0004381 VSAO:0000300 free limb skeleton limb skeleton set of bones of limb uberon entire sense organ system FMA:78499 Sum of all sensory systems in an organism. UBERON:0004456 note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs sense organ system uberon anatomical projection A projection or outgrowth of tissue from a larger body or organ. AAO:0010278 Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, or tissue.[AAO] Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[TAO] Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[VSAO] FMA:67601 HAO:0000822 TAO:0001834 UBERON:0004529 VSAO:0000180 XAO:0004020 anatomical process anatomical protrusion flange flanges galen:Ridge lamella lamellae lamina laminae organ process papilla process process of organ processes processus projection projection projections protrusion ridge ridges shelf shelves should be declared disjoint from organ, but in some ontologies (e.g. ZFA), structures such as neural spines are classified as bones (and hence organs) spine uberon cardiovascular system AAO:0011001 Anatomical system that has as its parts the heart and blood vessels. BILA:0000016 BTO:0000088 CALOHA:TS-1297 CV system EFO:0000791 EHDAA2:0000216 EHDAA:394 EMAPA:16104 EMAPA:16370 EV:0100017 FMA:7161 GAID:467 Herz und Gefaesssystem MA:0000010 MAT:0000016 MESH:D002319 MIAA:0000016 OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA TAO:0000010 The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG] UBERON:0004535 UMLS:C0007226 VHOG:0000302 WikipediaCategory:Cardiovascular_system XAO:0000100 XAO:0001010 ZFA:0000010 uberon we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph. blood vasculature A vascular network consisting of blood vessels. TAO:0001079 UBERON:0004537 ZFA:0001079 blood system blood vascular network blood vessel system blood vessels set of blood vessels uberon paired limb/fin An appendage that is part of a appendage girdle complex. UBERON:0004708 UBERON:0009872 VSAO:0000067 girdle-associated appendage jointed paired lateral appendage limb or fin limb/fin paired appendage pectoral or pelvic appendage pelvic/pectoral appendage this class is the union of the classes limb, pectoral fin and pelvic fin. uberon conceptus AEO:0000194 BTO:0003834 EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus EHDAA2:0000001 EHDAA2:0003235 EMAPA:36040 The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. UBERON:0004716 UMLS:C1516779 embryo plus adnexa uberon segmental subdivision of nervous system Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. FBbt:00005140 UBERON:0004732 neuromere revisit this after CARO is revised and/or we have defined metameric segment; note that with the additional of an A/P axis constraint this corresponds to what Richter at al call a neuromere (PMID:21062451) uberon segmental subdivision of hindbrain An organ subunit that is part of a hindbrain [Automatically generated definition]. FMA:61998 UBERON:0004733 hindbrain segment segment of hindbrain uberon gastrula BILA:0000060 BTO:0001403 FBbt:00005317 FMA:293108 GAID:1302 MESH:A16.254.412 MIAA:0000179 Organism at the gastrula stage. UBERON:0004734 UBERON:0007012 UMLS:C0017199 UMLS:C1284022 We explicitly merge the NCITA terms here blastocystis trilaminaris gastrula embryo tri-laminar disc tri-laminar disk trilaminar blastocyst trilaminar blastoderm trilaminar disc trilaminar disk trilaminar germ uberon skeletal tissue A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from MA:0003047 UBERON:0004755 VSAO:0000015 XAO:0004038 ZFA:0005619 uberon skeletal element AAO:0011129 Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] TAO:0001890 UBERON:0004765 VSAO:0000128 XAO:0004012 ZFA:0005494 galen:SkeletalStructure uberon articular system Anatomical system that consists of all the joints of the body. EMAPA:35150 FMA:23878 MA:0003007 UBERON:0004770 VSAO:0000181 joint system set of all joints set of all joints of body set of joints of body uberon splanchnic layer of lateral plate mesoderm AAO:0011102 BILA:0000044 FMA:295568 Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. UBERON:0004872 We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors XAO:0000276 inner layer of lateral plate mesoderm splanchnic mesoderm uberon visceral mesoderm chordamesoderm AAO:0000478 EFO:0003426 Notochord rudiment[ZFIN:ZDB-PUB-961014-576]. TAO:0000091 The central region of trunk mesoderm. This tissue forms the notochord UBERON:0004880 WP treats this as synonym of axial mesoderm. Induces neural tube. Gilbert: contains an anterior head process and the notochord. ZFA:0000091 axial chorda mesoderm chorda mesoderm dorsal mesoderm presumptive notochord uberon articulation Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. FBbt:00005811 UBERON:0004905 joint uberon subdivision of digestive tract A proximal-distal subdivision of the digestive tract. FBbt:00100315 FMA:71131 UBERON:0004921 alimentary system subdivision intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct. intestinal tract segment of intestinal tract subdivision of alimentary system uberon organ component layer A part of a wall of an organ that forms a layer. FMA:82485 UBERON:0004923 uberon neural groove AAO:0011071 EMAPA:35594 FMA:295624 The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]. UBERON:0005061 UMLS:C0814992 XAO:0000248 uberon neural fold EHDAA2:0001249 EMAPA:16142 EMAPA:16146 EMAPA:16151 EMAPA:16155 EMAPA:16159 EMAPA:16162 EMAPA:16288 EMAPA:16292 EMAPA:16295 EMAPA:16299 EMAPA:16303 EMAPA:16307 EMAPA:16528 FMA:295618 In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]. One of the two elevated edges of the neural groove[GO,MP]. UBERON:0005062 UMLS:C0814993 XAO:0004087 medullary fold uberon neural rod A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO] EFO:0003498 TAO:0000133 UBERON:0005068 ZFA:0000133 neural tube rod uberon ectodermal placode AEO:0000218 An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO] FMA:293966 UBERON:0005085 With the exception of the adenohypophysis, homologues of the nonneurogenic placodes (e.g. placodes giving rise to the teeth, hair follicles and lens), appear to be lacking in invertebrate chordates. consder adding placodal ectoderm as a distinct class? Also place placodal ectoderm as develops_from ectoderm; need to check taxon-appropriateness epithelial placode in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous. uberon muscle structure EMAPA:32715 FBbt:00005073 FMA:30316 Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. UBERON:0005090 in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila muscle muscle element musculus uberon epithelial bud A bud is a protrusion that forms from an epithelial sheet by localized folding. BTO:0001639 UBERON:0005153 uberon epithelial fold An epithelial sheet bent on a linear axis. UBERON:0005157 uberon multi cell part structure A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. AAO:0011000 CARO:0001000 FBbt:00007060 FMA:83115 UBERON:0005162 cell part cluster multi-cell-component structure multi-cell-part structure uberon we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.' dorsal region element An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. MA:0001901 UBERON:0005174 back organ dorsal region organ uberon trunk region element An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. MA:0000516 UBERON:0005177 trunk organ uberon thoracic cavity element An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. MA:0000557 UBERON:0005178 thoracic cavity organ uberon thoracic segment organ An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. MA:0000563 UBERON:0005181 uberon upper body organ trunk mesenchyme EFO:0003485 EHDAA2:0002092 EHDAA:377 EMAPA:16177 Mesenchyme that is part of a developing trunk. TAO:0000081 UBERON:0005256 VHOG:0000281 ZFA:0000081 trunk and cervical mesenchyme uberon myelencephalon BTO:0000758 CALOHA:TS-0607 CALOHA:TS-2365 DHBA:10662 EHDAA2:0001207 EHDAA:5526 EMAPA:17082 HBA:9512 MA:0000205 The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. UBERON:0005290 VHOG:0000456 myelencephalon (medulla oblongata) the terms metencephalon and myelencephalon are only meaningful in mammals and birds - Neuroanatomy of the Zebrafish Brain. Note that its not clear if this refers to the developing medulla oblongata - MA (adult) has two distinct classes uberon embryonic tissue A portion of tissue that is part of an embryo. CALOHA:TS-2100 UBERON:0005291 developing tissue portion of embryonic tissue uberon alimentary part of gastrointestinal system All metazoans (with degenerate exceptions) have some sort of digestive cavity with a means of entrance to and exit from it.[well established][VHOG] BTO:0000058 CALOHA:TS-0407 EHDAA2:0000110 EHDAA:514 EMAPA:16246 EV:0100056 FMA:71132 GAID:294 GI tract MA:0000323 MESH:A03.492 The part of the digestive system that excludes the hepatobiliary system. The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas[ncithesaurus:Gastrointestinal_System]. UBERON:0005409 UMLS:C0012240 VHOG:0000412 alimentary system alimentary tract galen:GastrointestinalTract gastro-intestinal system gastrointestinal (GI) tract gastrointestinal system gastrointestinal tract that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ampulla. the decision to split digestive and gastrointestinal in this way may be revisited. As it currently stands, this class more closely aligns what MA calls the alimentary system uberon developing anatomical structure AEO:0000125 CALOHA:TS-2122 EHDAA2:0003125 FBbt:00007006 FMA:292313 MIAA:0000019 UBERON:0005423 developing structure developmental structure developmental tissue uberon non-neural ectoderm After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm. EFO:0003643 EHDAA:257 EMAPA:16074 Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). Editor note: todo - epidermis? todo - track down EHDAA2 class in new release In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG] RETIRED_EHDAA2:0001273 TAO:0001178 UBERON:0005497 VHOG:0001372 XAO:0004091 ZFA:0001178 epidermal ectoderm epithelial ectoderm non neural ectoderm surface ectoderm uberon ventral ectoderm primitive heart tube EHDAA2:0001512 EHDAA:424 EHDAA:436 EMAPA:16208 EMAPA:16215 FMA:321916 Multi-tissue structure that arises from the heart rudiment and will become the heart tube. TAO:0000149 UBERON:0005498 ZFA:0000149 early primitive heart tube primitive heart tube uberon lung primordium A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. AAO:0011059 EFO:0002578 EMAPA:36007 UBERON:0005597 UBERON:3010717 XAO:0001002 lateral diverticula lung diverticulum lung endoderm uberon olfactory system A sensory system that is capable of olfacttion (the sensory perception of smell). AAO:0000334 AAO:0000978 BILA:0000144 EFO:0001973 EMAPA:36004 FMA:7190 In mammals, the main olfactory system detects odorants that are inhaled through the nose, where they contact the main olfactory epithelium, which contains various olfactory receptors. These olfactory receptors are membrane proteins of bipolar olfactory receptor neurons in the olfactory epithelium. Rather than binding specific ligands like most receptors, olfactory receptors display affinity for a range of odor molecules. Olfactory neurons transduce receptor activation into electrical signals in neurons. The signals travel along the olfactory nerve, which belongs to the peripheral nervous system. This nerve terminates in the olfactory bulb, which belongs to the central nervous system. The complex set of olfactory receptors on different olfactory neurons can distinguish a new odor from the background environmental odors and determine the concentration of the odor[WP]. MA:0002445 OpenCyc:Mx4rvViw75wpEbGdrcN5Y29ycA TAO:0001149 The olfactory system is the sensory system used for olfaction, or the sense of smell. Most mammals and reptiles have two distinct parts to their olfactory system: a main olfactory system and an accessory olfactory system. The main olfactory system detects volatile, airborne substances, while the accessory olfactory system senses fluid-phase stimuli. Behavioral evidence indicates that most often, the stimuli detected by the accessory olfactory system are pheromones. The olfactory system is often spoken of along with the gustatory system as the chemosensory senses because both transduce chemical signals into perception[WP][Wikipedia:Olfactory_system]. The sensory system used for olfaction (the sense of smell).[AAO] UBERON:0005725 UMLS:C0228065 XAO:0003196 ZFA:0001149 consider splitting into main and accessory. See also: vomeronasal organ uberon we make the relationship to nervous system 'overlaps', as the olfactory system includes e.g. apertures in the cranium that are not part of the nervous system chemosensory system BILA:0000139 UBERON:0005726 uberon fin field A limb/fin field that has_potential_to_developmentally_contribute_to a paired fin bud. UBERON:0005731 fin field of lateral plate mesoderm uberon paired limb/fin field A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. UBERON:0005732 limb/fin field of lateral plate mesoderm paired limb/fin field uberon we represent the field as being a part of the LPM (consistent with ZFA, Gilbert). As a consequence, the relationship between limb bud (with is ectoderm+mesenchyme) stands in a weaker has_developmental_contribution_from relation to the field - TODO implement this. limb field A ring of cells capable of forming a limb. UBERON:0005733 limb field of lateral plate mesoderm the central portion of the limb field gives rise to the limb proper. mesenchyme cells proliferate from from the somatic layer of limb field lateral plate mesoderm (limb skeletal precursors) and from the somites (limb muscle precursors) . these mesenchymal cells accumulate under the ectedermal tissue to make a limb bud. // The lateral plate mesoderm in the limb field is also special in that it will induce myoblasts to migrate out from the somites and enter the limb bud. No other region of the lateral plate mesoderm will do that (Hayashi and Ozawa 1995) uberon acellular membrane A acellular anatomical structure that is the bounding layer of a anatomical structure. FMA:63871 UBERON:0005764 uberon basement membrane of epithelium AAO:0010596 An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. FMA:63872 GAID:915 UBERON:0005769 UMLS:C0004799 basement membrane basement membrane of connective tissue membrana basalis this class represents a continuous sheet of basement membrane which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal membrane' represents a portion of substance on the scale of a single cell. uberon developing mesenchymal condensation A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 EHDAA:8979 UBERON:0005856 mesenchyme condensation uberon cartilaginous condensation AEO:0000147 Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. EHDAA2_RETIRED:0003147 EMAPA:32731 UBERON:0005863 VSAO:0000092 XAO:0004022 cartilage condensation cartilagenous condensation chondrogenic condensation isa cell condensation in VSAO; has_part chondroblast in AEO uberon pre-cartilage condensation A closely packed aggregation of mesenchymal cells just prior to their differentiation into embryonic cartilage. A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. AEO:0000150 EHDAA2:0003150 EMAPA:32736 UBERON:0005866 pre-chondrogenic condensation precartilage condensation precartilagenous condensation prechondrogenic condensation uberon autopodial extension A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis. UBERON:0005881 digit or predigit encompasses digits and prepollex. requires review limb outgrowth uberon serous sac EMAPA:16060 FMA:9689 MA:0000005 Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA] See notes for serous membrane UBERON:0005906 uberon endo-epithelium Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA] FMA:69065 UBERON:0005911 endoderm-derived epithelium endoepithelium uberon axial skeleton plus cranial skeleton AAO:0000963 EMAPA:17214 EMAPA:18043 MA:0000308 Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO] Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. UBERON:0005944 UMLS:C0222645 VSAO:0000056 XAO:0004011 http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton skeleton axiale uberon integumentary adnexa Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. UBERON:0006003 add subclasses based on resolution of CARO tracker item. Also check: adnexal gland. Note that MP implicitly includes hypodermis. adnexae cutis body hair or bristle skin adnexa skin adnexal structure skin appendage the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails[MP:0010678] uberon rhombic lip DHBA:10664 EHDAA2:0000231 EMAPA:17074 TAO:0001440 The interface between the dorsal neuroepithelium and the roofplate of the fourth ventricle. The source of a number of migratory neuron populations of the hindbrain.[TAO] UBERON:0006215 UBERON:0013163 XAO:0004135 ZFA:0001440 cerebellar anlage cerebellar primordium cerebellum primordium dorsal part of alar plate of metencephalon future cerebellum presumptive cerebellum rostral rhombic lip the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system uberon future brain BAMS:Enc BTO:0004726 EFO:0003431 EHDAA:300 EHDAA:830 EMAPA:16089 EMAPA:16471 FMA:312967 RETIRED_EHDAA2:0000591 TAO:0000146 The embryonic precursor of the brain and the set of mature brain structures that derive from it (CUMBO) The embryonic precursor of the brain. UBERON:0006238 ZFA:0000146 brain rudiment embryonic brain encephalon presumptive brain uberon future forebrain A presumptive structure that has the potential to develop into a forebrain. BAMS:Pros EFO:0003423 EHDAA2:0000661 EHDAA:2643 EMAPA:16640 TAO:0000062 TODO. Add relationships to neural plate (both ZFA and EMAPA time this with the neural plate) UBERON:0006240 ZFA:0000062 future prosencephalon presumptive forebrain presumptive prosencephalon prosencephalon uberon future spinal cord EFO:0003438 EHDAA2:0000674 EHDAA:898 EMAPA:16092 EMAPA:16525 EMAPA:16755 TAO:0000417 UBERON:0006241 ZFA:0000417 presumptive spinal cord presumptive spinal cord neural keel presumptive spinal cord neural plate presumptive spinal cord neural rod uberon notochordal plate EHDAA2:0001278 EHDAA:264 EMAPA:16101 TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] UBERON:0006267 UMLS:C1518429 VHOG:0001212 uberon notochordal process A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot EHDAA2:0001279 EHDAA:224 EMAPA:16102 FMA:293135 The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. UBERON:0006268 UMLS:C1518430 VHOG:0001213 chordamesoderm presumptive notochord uberon bodily fluid FMA:280556 GAID:266 Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. MESH:D001826 UBERON:0006314 body fluid fluid galen:BodyFluid uberon pharynx FBbt:00005380 MAT:0000049 MIAA:0000049 The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. UBERON:0006562 anterior part of foregut branchial currently this is an extremely generic class, encompassing both protostomes and deuterostomes. pharyngeal pharyngeal tube uberon presumptive endoderm AAO:0000471 EFO:0003437 Presumptive structure of the blastula that will develop into endoderm. TAO:0000416 UBERON:0006595 ZFA:0000416 uberon presumptive blood AAO:0000468 EFO:0003439 TAO:0000568 UBERON:0006596 ZFA:0000568 future blood uberon presumptive structure AAO:0000479 Consider merging with anlage Portion of embryonic tissue determined by fate mapping to become a structure. TAO:0001116 UBERON:0006598 ZFA:0001116 future structure presumptive structures uberon presumptive ectoderm AAO:0000470 EFO:0003466 Presumptive structure of the blastula that will develop into ectoderm. TAO:0001376 UBERON:0006601 XAO:0004132 ZFA:0001376 presumptive epidermis uberon presumptive mesoderm AAO:0000476 EFO:0003467 Presumptive structure of the blastula that will develop into mesoderm. TAO:0001377 UBERON:0006603 ZFA:0001377 uberon interphalangeal joint 2 2 A joint that connects one phalanx to another along a proximodistal axis. FMA:42765 Hinge joints between the phalanges of the hand or foot[ncithesaurus:Interphalangeal_Joint]. UBERON:0006658 galen:InterphalangealJoint inter-phalangeal joint inter-phalanx joint uberon mesopodium region Naming conventions for pod terms under discussion within phenoscape group The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus) UBERON:0006716 carpus/tarsus mesopod mesopodial limb segment mesopodial segment uberon autopodial skeleton Distal section of the limb skeleton, consisting of the anterior autopodium or posterior autopodium.[VSAO] Naming conventions for pod terms under discussion within phenoscape group The collection of all skeletal elements in an autopodium region. UBERON:0006717 VSAO:0005019 autopod skeleton autopodial skeleton autopodium skeletal parts of autopod skeleton of autopod uberon squamous epithelium An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. BTO:0002072 FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium UBERON:0006914 UMLS:C0221909 uberon vascular cord EFO:0003709 TAO:0005077 The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. UBERON:0006965 ZFA:0005077 uberon anatomical surface A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n AAO:0010270 BILA:0000010 CARO:0001002 EHDAA2:0003192 FMA:24137 ID:0000000 Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. UBERON:0006984 UMLS:C1515977 ZFA:0005594 uberon cardiac mesoderm AAO:0011021 BILA:0000051 EFO:0000315 EHDAA2:0000214 EHDAA:385 FMA:293143 The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. UBERON:0007005 VHOG:0001641 XAO:0000235 cardiogenic mesoderm cardiogenic region consider FBbt:00005541 ! cardiogenic mesoderm heart primordia review EHDAA2 placement uberon cleaving embryo BILA:0000058 Organism at the cleavage stage. UBERON:0007010 uberon presumptive gut BILA:0000084 The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis UBERON:0007026 UMLS:C1514442 embryonic digestive tube future digestive tract future digestive tube future gut primitive gut primordial digestive tube primordial gut uberon primary circulatory organ A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. FBbt:00003154 Gene notes: Bmp, Nkx, Gata SPD:0000130 TADS:0000147 UBERON:0007100 adult heart dorsal tube heart note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis uberon neural keel An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO] EFO:0003497 TAO:0000131 UBERON:0007135 ZFA:0000131 presumptive central nervous system uberon presumptive hindbrain BAMS:HB CALOHA:TS-2118 EFO:0003440 EHDAA2:0001630 FMA:295640 TAO:0000569 TODO - unify naming conventions The embryonic rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. Rhombomeres Rh7-Rh4 form the myelencephalon that will give the medulla oblongata. Rhombomeres Rh3-Rh1 form the metencephalon that will form the pons and the cerebellum[NPX:PDR]. The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. UBERON:0007277 ZFA:0000569 embryonic rhombencephalon future hindbrain presumptive rhombencephalon rhombencephalon uberon presumptive midbrain hindbrain boundary EFO:0003446 Embryonic structure that gives rise to the midbrain hindbrain boundary. TAO:0001187 UBERON:0007281 XAO:0004086 ZFA:0001187 presumptive MHB presumptive midbrain-hindbrain boundary uberon presumptive segmental plate A presumptive structure that has the potential to develop into a presomitic mesoderm. EFO:0003421 TAO:0000053 UBERON:0007282 ZFA:0000053 presumptive segmental plates uberon presumptive neural plate A presumptive structure that has the potential to develop into a neural plate. EFO:0003424 Region of the gastrula which gives rise to the neural plate.[TAO] TAO:0000063 UBERON:0007284 ZFA:0000063 consider merging prospective neuroectoderm prospective vegetal ectoderm uberon presumptive paraxial mesoderm A presumptive structure that has the potential to develop into a paraxial mesoderm. EFO:0003443 TAO:0000591 UBERON:0007285 XAO:0004134 ZFA:0000591 future paraxial mesoderm uberon outer epithelium BSA:0000073 BTO:0000313 FBbt:00004993 HAO:0000298 TADS:0000109 The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. UBERON:0007376 WBbt:0005733 epidermis epidermis (sensu Metazoa) hypoderm hypodermis outer epidermal layer outer epithelial layer this grouping class exists primarily to align with GO - see GO:0008544. uberon stratum compactum AAO:0010600 Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. Le Guellec et al, 2004.[TAO] TAO:0001182 UBERON:0007377 ZFA:0001182 connective tissue in the skin is usually diffuse and irregular, although in some species collagen bundles are arranged in a distinct ordered layer in the dermis dermal deep region relationship loss: develops_from collagenous dermal stroma (TAO:0001186)[TAO] uberon enveloping layer of ectoderm EFO:0003425 EVL Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm. Outermost layer of cells surrounding the embryo. Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO] TAO:0000086 UBERON:0007383 ZFA:0000086 enveloping layer relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO] uberon epithelial tube open at both ends AEO_RETIRED:0000116 An epithelial tube open at both ends that allows fluid flow. RETIRED_EHDAA2:0003116 UBERON:0007500 uberon epithelial vesicle A closed epithelium with a lumen. AEO:0000119 EHDAA2:0003119 EHDAA2:0003119 UBERON:0007503 uberon dense mesenchyme tissue AEO:0000146 EHDAA2:0003146 EHDAA2:0003146 Mesenchyme with little extracellular matrix. UBERON:0007524 uberon migrating mesenchyme population AEO:0000152 EHDAA2:0003152 EHDAA2:0003152 Mesenchymal cells that are migrating. UBERON:0007530 this class will be an important part of the NC reorganization uberon layer of synovial tissue A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. BTO:0001338 CALOHA:TS-0998 FMA:66762 UBERON:0007616 stratum synoviale synovial layer synovial membrane synovial tissue synovium uberon synovial cavity of joint An anatomical cavity that surrounded_by a synovial joint. FMA:11356 UBERON:0007617 articular cavity (synovial joint) cavitas articularis (junctura synovialis) cavity of synovial joint joint cavity synovial cavity uberon anatomical junction 2 An anatomical structure that connects two structures FMA:5898 UBERON:0007651 anatomical junction junction uberon anlage AEO:0000170 Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. EFO:0001649 EHDAA2:0003170 FBbt:00005426 UBERON:0007688 developmental field field future organ organ field uberon serous fluid Any fluid produced by a serous gland. FMA:20932 UBERON:0007794 serous gland fluid the FMA def is Transudate contained in a serous sac uberon vascular system Anatomical system that consists of all blood and lymph vessels. BTO:0001085 CALOHA:TS-2053 EHDAA2:0004520 EMAPA:35905 Gefaesssystem@ge MA:0002718 The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. UBERON:0007798 UMLS:C0489903 consider merging with vasculature in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system uberon craniocervical region CALOHA:TS-2356 EV:0100009 FMA:280881 MA:0000006 The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. UBERON:0007811 UMLS:C0460004 WikipediaCategory:Head_and_neck cephalic area cephalic part of animal cephalic region galen:HeadAndNeck head and neck head or neck uberon appendage girdle region An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There are only two instances of appendage girdle regions per organism.[VSAO] FMA:24874 UBERON:0007823 UBERON:0007824 VSAO:0000303 fin girdle fin girdle region girdle girdle region limb girdle limb girdle region this encompasses non-skeletal tissue uberon cartilage element AAO:0011130 CALOHA:TS-0118 EMAPA:32730 FMA:55107 Skeletal element that is composed of cartilage tissue and may be permanent or transient. TAO still mixes tissue and element UBERON:0007844 VSAO:0000000 XAO:0004013 ZFA:0001501 cartilage cartilage organ cartilaginous element chondrogenic element uberon regular connective tissue Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. FMA:20103 UBERON:0007845 the connective tissue hierarchy largely follows FMA with definitions from VSAO. Note that in FMA, loose-CT is irregular-CT. This means regular-CT is necessarily equivalent to dense-regular-CT (assuming a JEPD classification). uberon dense regular connective tissue Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).[VSAO] FMA:64781 Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.[FMA] UBERON:0007846 UMLS:C0225333 VSAO:0000050 XAO:0004030 dense fibrous connective tissue dense regular collagenous connective tissue dense regular collagenous tissue regular dense connective tissue typus regularis (textus connectivus collagenosus compactus) uberon fin AAO:0010374 AEO:0001004 An external projection of an aquatic animal as a fish used in propelling or guiding the body[BTO]. BTO:0004649 EFO:0000875 MAT:0000087 MESH:D058500 MIAA:0000087 OpenCyc:Mx4rvVjcBZwpEbGdrcN5Y29ycA Surface structure involved in locomotion.[TAO] Surface structure involved in locomotion.[VSAO] TAO:0000108 This class groups together various structures that may have arisen through convergent evolution, including, for example, the dorsal fin of a cetacean UBERON:0008897 VSAO:0000099 XAO:0000002 ZFA:0000108 fins uberon respiratory primordium EHDAA2:0004069 UBERON:0008947 UMLS:C1514898 uberon entire embryonic mesenchyme EHDAA2:0001113 EHDAA:177 EMAPA:16097 Sum total of mesenchyme in the embryo. UBERON:0003313 UBERON:0009142 consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm) uberon distal segment of digit A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium). Newborn and adult mice are able to regrow forelimb (finger) and hindlimb (toe) digit tips after their amputation through the distal interphalangeal joint. Regeneration of the digit tip involves the integrated regrowth of multiple tissues within 2-3 months, reaching an external morphology that is cosmetically and functionally similar to normal digits. Most importantly, regeneration of the mouse distal digit shares morphological similarities with clinical cases documenting regrowth of missing distal portions of fingers in both children and adults UBERON:0009551 digit tip distal digit segment tip of digit uberon distal limb integumentary appendage A nail, hoof or claw. MESH:D006724 UBERON:0009564 hoof or claw hoof, claw or nail keratin plate keratin sheath uberon unguis subdivision of trunk FMA:25054 UBERON:0009569 region of trunk trunk subdivision uberon midbrain mantle layer EHDAA2:0001172 EMAPA:16977 UBERON:0009581 VHOG:0000910 mantle layer lateral wall mesencephalon mantle layer lateral wall midbrain midbrain lateral wall mantle layer uberon midbrain hindbrain boundary neural plate MHB neural plate TAO:0007044 TODO - developmental relationships for lines UBERON:0009615 ZFA:0007044 midbrain-hindbrain boundary neural plate uberon presumptive midbrain A presumptive structure that has the potential to develop into a midbrain. BAMS:MES EFO:0003432 EHDAA2:0000615 EMAPA:16140 EMAPA:16472 TAO:0000148 TODO - unify naming conventions UBERON:0009616 ZFA:0000148 early midbrain future midbrain mesencephalon presumptive mesencephalon uberon trunk paraxial mesoderm EHDAA2:0002094 UBERON:0009618 trunk and cervical paraxial mesenchyme trunk paraxial mesenchyme uberon limb mesenchyme EMAPA mapping from TH EMAPA:32705 The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells. UBERON:0009749 limb mesoderm uberon distal interphalangeal joint An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx. DIJ joint DIP joint FMA:65024 UBERON:0009768 uberon glandular acinus FMA:55588 The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. UBERON:0009842 acinar acini acinus uberon metapodium region Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region Naming conventions for pod terms under discussion within phenoscape group UBERON:0009877 cannon region considering adding 'acropodial region' equine cannon region metacarpal or metatarsal part of limb metacarpus/metatarsus metacarpus/metatarsus region metapodial segment metapodium uberon mesopodial skeleton Limb skeleton subdivision consisting of endochondral bones increasing the freedom of movement of the autopodia, and located between zeugopodia and autopodia.[VSAO] The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton UBERON:0009878 VSAO:0005022 basipodium basipodium skeleton carpal/tarsal skeleton mesopodial skeleton mesopodium mesopodium skeleton relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO] skeletal parts of mesopodium uberon anterior lateral plate mesoderm ALPM EFO:0003704 TAO:0005041 UBERON:0009881 ZFA:0005041 uberon neurogenic placode Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. EFO:0003460 Includes: trigeminal, otic, lateral line and epibranchial placodes. TAO:0001309 UBERON:0009955 While some sensory placodes (otic and olfactory) may have homologues in basal chordates (Wada et al., 1998), the so-called neurogenenic placodes (trigeminal, otic, lateral line and epibranchial placodes) appear to have emerged at a later time (Shimeld and Holland, 2000) XAO:0004620 ZFA:0001309 neurogenic placodes placodae neurogenicae uberon multicellular anatomical structure An anatomical structure that has more than one cell as a part. CARO:0010000 FBbt:00100313 UBERON:0010000 multicellular structure uberon cell cluster organ A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function. CARO:0010001 Examples include arthropod sensilla. FBbt:00007229 UBERON:0010001 uberon future dermis EHDAA2:0000598 Mesenchyme that has the potential to develop into a dermis. UBERON:0010083 check development uberon future metencephalon A developing anatomical structure that has the potential to develop into a metencephalon. EHDAA2:0000623 UBERON:0010092 uberon future myelencephalon A developing anatomical structure that has the potential to develop into a myelencephalon. EHDAA2:0000640 UBERON:0010096 uberon autopod plate The distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. manus, pes, paw) UBERON:0010130 limb plate uberon midbrain basal plate DHBA:12322 EFO:0003567 EHDAA2:0004375 Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. TAO:0000761 UBERON:0010285 ZFA:0000761 basal plate midbrain basal plate midbrain region uberon midbrain neural tube Portion of neural tube that gives rise to the midbrain. TAO:0007039 UBERON:0010286 ZFA:0007039 uberon we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed structure with developmental contribution from neural crest An anatomical structure that has some part that develops from the neural crest. Grouping term for query purposes UBERON:0010314 uberon germ layer / neural crest UBERON:0010316 uberon endochondral element A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. UBERON:0010363 VSAO:0000139 XAO:0004017 ZFA:0005620 endochondral replacement element https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern uberon ecto-epithelium Epithelium composed of cells that develops from the ectoderm[FMA,modified]. FMA:69064 UBERON:0010371 ectoderm-derived epithelium uberon paired limb/fin segment An appendage segment that is part of a limb/fin. UBERON:0010538 limb/fin segment uberon acropodial skeleton FMA:231315 The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]. UBERON:0010543 VSAO:0005028 acropodial skeleton acropodium acropodium skeleton digital skeleton digits skeleton phalangeal skeleton set of phalanges skeletal parts of acropodial region skeletal parts of acropodium skeleton of digits uberon metapodial skeleton Endochondral bone complex located between the mesopodium and the acropodium and consisting of the metacarpals or metatarsals.[VSAO] Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton. UBERON:0010546 VSAO:0005025 metacarpal/metatarsal skeleton metapodial skeleton metapodium metapodium skeleton relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: connected_to subdivision of skeleton (UBERON:0010912)[VSAO] relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO] skeletal parts of metapodium skeleton of metapodium uberon phalanx pre-cartilage condensation EMAPA:32720 UBERON:0010700 uberon phalanx cartilage element EMAPA:32721 UBERON:0010701 uberon digit mesenchyme EMAPA:32719 Mesenchyme of the digit region. UBERON:0010702 digital ray uberon appendage girdle complex 2012-04-23T10:46:51Z An organism subdivision that includes both an appendage and its accociated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Anatomical group that consists of the soft and skeletal tissues of the appendicular region of the body and the appendage proper.[VSAO] FMA:7182 It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO] It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO] UBERON:0010707 VSAO:0000214 appendage complex appendage-girdle complex appendage/girdle complex girdle plus limb or fin haendel limb note that the FMA uses the term 'limb' to refer to the entire appendage complex (free limb plus girdle region) uberon limb skeleton subdivision Skeletal subdivision that is a segment of the limb skeleton. UBERON:0010712 VSAO:0005018 note the distinction between this and skeleton of limb uberon paired fin skeleton Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO] Skeletal system that consists of the paired fins (pectoral or pelvic fins).[VSAO] TAO:0000027 The collection of all skeletal elements in a single paired fin. UBERON:0010713 VSAO:0000169 ZFA:0000027 uberon girdle skeleton AAO:0010686 Skeletal subdivision that is part of the appendage girdle region.[VSAO] The subdivision of the skeleton of either the pectoral or pelvic girdle. UBERON:0010719 VSAO:0000302 relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: part_of subdivision of skeleton (UBERON:0010912)[VSAO] relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: proximally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO] skeleton of girdle uberon bone of appendage girdle complex A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). EMAPA:35494 MA:0000688 UBERON:0010740 bone of extended limb/fin region limb bone uberon subdivision of organism along appendicular axis A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg. FBbt:00007018 UBERON:0010758 appendage segment appendicular segment uberon limb cartilage element A skeletal element that is part of a limb and composed of cartilage tissue. UBERON:0010881 uberon limb bone pre-cartilage condensation A skeletal element that is part of a limb and composed of pre-cartilage tissue. UBERON:0010882 uberon subdivision of skeleton Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 UBERON:0010912 VSAO:0000042 skeletal subdivision subdivision of skeleton (in vivo) uberon nonsynovial joint FMA:7491 Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. UBERON:0011134 solid joint uberon axial skeletal system FMA:7483 Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. UBERON:0011137 http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton uberon post-cranial axial skeletal system FMA:302077 Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints. UBERON:0011138 axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton uberon synovial limb joint Any synovial joint that is part of a (free) limb. FMA:258776 Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses. UBERON:0011139 synovial joint of free limb segment uberon central nervous system cell part cluster A multi cell part structure that is part of a central nervous system. FMA:83143 UBERON:0011215 cell part cluster of neuraxis neuraxis layer uberon organ system subdivision A subdivision of an anatomical system. FBbt:00007330 FMA:67509 UBERON:0011216 uberon appendicular skeletal system FMA:7484 Skeletal system which consists of the appendicular skeleton plus associated joints.[VSAO] Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. UBERON:0011249 VHOG:0001666 VSAO:0000306 https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton uberon autopod bone A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones. UBERON:0011250 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern uberon embryonic skin basal layer EHDAA2:0001845 UBERON:0011272 basal cell layer of skin compare with 'stratum basale of epidermis'. This class is the source for many adult structures - see WP2062. See also: 'enveloping layer of ectoderm' outer epithelium of body uberon paired limb/fin skeleton Skeletal subdivision that is part of the paired limb/fin.[VSAO] The collection of all skeletal elements in an individual limb or fin. UBERON:0011582 VSAO:0000301 limb/fin skeleton skeletal parts of limb/fin skeleton of limb/fin uberon stylopodial skeleton Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]. Proximal element of the limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively.[VSAO] UBERON:0011583 VSAO:0005007 mesomere 1 propodial propodial skeleton propodium proximal metapterygial mesomere stylopod stylopodial stylopodium stylopodium skeleton uberon zeugopodial skeleton Section of the forelimb skeleton located between the stylopodium and the autopodium. UBERON:0011584 VSAO:0005010 epipodial skeleton epipodium mesomere 2 mesomere 2 skeleton skeleton of zeugopod uberon zeugopod skeleton zeugopodial zygopodial zygopodium cell condensation Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). UBERON:0011585 VSAO:0000006 XAO:0004021 consider obsoleting, coordinate with VSAO uberon subdivision of organism along main body axis A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem UBERON:0011676 axial subdivision of organism body segment main body segment uberon embryonic cardiovascular system A cardiovascular system that is part of a conceptus. EHDAA2:0000216 FMA:305965 UBERON:0011695 conceptus cardiovascular system embryonic circulatory system fetal circulatory system uberon nerve of head region A nerve that is part of a head. UBERON:0011779 cephalic nerve head nerve uberon irregular connective tissue Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. FMA:20107 UBERON:0011821 uberon dense irregular connective tissue FMA:20109 Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT] UBERON:0011822 UMLS:C0738366 irregular dense connective tissue typus irregularis (textus connectivus collagenosus compactus) uberon dense connective tissue AAO:0000121 Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT] Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets UBERON:0011823 UMLS:C1511770 our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid. uberon loose connective tissue FMA:19783 Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. UBERON:0011825 UMLS:C1253917 textus connectivus collagenosus laxus textus connectivus laxus uberon acinus of exocrine gland An acinus that is part of a exocrine gland. UBERON:0011858 exocrine gland acinus uberon collection of collagen fibrils FMA:63212 MESH:D024022 NIF_Subcellular:sao7547390221 UBERON:0011860 the FMA class specifically refers to ureter uberon epimysium Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. FMA:9726 The Epimysium also protects muscles from friction against other muscles and bones UBERON:0011899 UMLS:C0504096 epimysia fascia of muscle organ uberon coelom EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining. EHDAA2:0004731 The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. UBERON:0011997 coelem coelomic coelomic cavity enterocoelom haemocoelom schizocoelom uberon segment of autopod UBERON:0012139 uberon digitopodium region A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region. UBERON:0012140 acropodium (Wagner) https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod uberon skeleton of digitopodium A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton. UBERON:0012150 digitopodium https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod skeleton of digits some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod uberon meso-epithelium Epithelium that derives from the mesoderm. [Automatically generated definition]. FMA:86452 UBERON:0012275 mesoderm-derived epithelium mesoepithelium uberon fin skeleton Skeletal subdivision consisting of all the skeletal elements in a single fin. UBERON:0012353 skeleton of fin uberon acropodium region The segment of the autopod that is distal to the metapodial region and consists of the digits. UBERON:0012354 acropodial limb segment acropodial region acropodial segment of autopod class refers to an entire limb segment, not just the bones set of digits uberon digitopodium bone A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton. UBERON:0012357 digit bone uberon serous acinus FMA:86279 The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. UBERON:0013232 acinus of serous gland uberon space surrounding organism The space that surrounds an organism. UBERON:0013514 external to organism outside of body uberon subdivision of tube UBERON:0013522 uberon anatomical conduit space 2 2 An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. FMA:9338 UBERON:0013686 foramen space uberon main body axis A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. UBERON:0013701 uberon body proper AEO:0000103 BTO:0001489 Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]. EMAPA:36031 FMA:231424 The region of the organism associated with the visceral organs. UBERON:0013702 body uberon whole body integumentary projection Anatomical projection that is part of the integumentl system. UBERON:0013703 skin projection uberon integumentary system layer A organ component layer that is part of a integumental system. UBERON:0013754 layer of skin skin layer uberon future telencephalon EHDAA2:0004424 EMAPA:36024 Embryonic structure that gives rise to the telencephalon. TAO:0000571 UBERON:0014371 ZFA:0000571 paired anteriolateral division of the embryonic prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived[MP] presumptive telencephalon uberon thoracic skeleton EHDAA2:0002013 FMA:77169 Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. UBERON:0014477 skeleton of thorax thoracic part of axial skeleton thoracic skeleton uberon skeletal muscle organ A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). AAO:0011099 BTO:0001103 CALOHA:TS-0933 EFO:0000888 EHDAA:5035 EHDAA:5043 EHDAA:5978 EHDAA:5984 EMAPA:35988 EV:0100377 GAID:141 MA:0003148 MAT:0000302 MESH:D018482 MIAA:0000302 OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA TAO:0005277 UBERON:0014892 VHOG:0000319 XAO:0000174 ZFA:0005277 skeletal muscle uberon primordial vasculature A portion of tissue that will develop into vasculature. EFO:0003708 TAO:0005076 UBERON:0014903 ZFA:0005076 uberon phalanx endochondral element A phalanx bone or its cartilage or pre-cartilage precursor. UBERON:0015023 phalanx element phalanx skeletal element uberon limb endochondral element A limb bone or its cartilage or pre-cartilage precursor. UBERON:0015061 limb bone endochondral element limb bone skeletal element uberon autopod endochondral element A endochondral element that is part of a autopod region. UBERON:0015063 uberon autopod cartilage A autopod endochondral element that is composed primarily of a cartilage tissue. UBERON:0015064 uberon lateral structure Any structure that is placed on one side of the left-right axis of a bilaterian. This class is primarily to implement taxon constraints. It may be removed in the future. UBERON:0015212 uberon circulatory organ A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. SPD:0000130 UBERON:0015228 cardiac pump cardiac structure circulatory vessel heart heart or heart like organ uberon heart plus pericardium MA:0002449 UBERON:0015410 heart/pericardium uberon foregut epithelium A epithelium that is part of a foregut. EMAPA:32922 MA:0003204 UBERON:0015833 uberon future central nervous system Primordium that develops into the central nervous system UBERON:0016879 UBERON:3000469 future CNS presumptive central nervous system uberon future nervous system AAO:0000477 Primordium that develops into the nervous system UBERON:0016880 UBERON:3000477 presumptive nervous system uberon entire extraembryonic component AEO:0000195 EHDAA2:0000003 EMAPA:16042 The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. UBERON:0016887 extra-embryonic component extraembryonic component uberon transitional anatomical structure AEO:0000132 An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. UBERON:0016888 uberon developing mesenchymal structure A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. AEO:0001016 UBERON:0017650 uberon skeletal musculature Added for consistency with MA EMAPA and EHDAA2. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/104 EHDAA2:0001842 EMAPA:35578 MA:0000165 UBERON:0018254 uberon developing neuroepithelium AEO:0001008 An embryonic or larval epithelium that is committed to form part of the nervous system. BTO:0000314 EHDAA2_RETIRED:0004654 FMA:64807 UBERON:0034705 embryonic neuroepithelium neurepithelium neuroepithelium uberon proliferating neuroepithelium AEO:0001009 An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. UBERON:0034706 uberon differentiating neuroepithelium A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. AEO:0001010 UBERON:0034707 uberon cranial neuron projection bundle Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain UBERON:0034713 cranial nerve fiber bundle cranial nerve fiber tract cranial nerve or tract neuron projection bundle from brain uberon morphological feature A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology. UBERON:0034768 uberon bodily gas Any substance in the body or expelled from the body that is in a gaseous state. FMA:84580 UBERON:0034873 gas in anatomical space portion of gas in anatomical space uberon air in respiratory system Any portion of gas located in a part of the respiratory system that is composed primarily of air. FMA:84581 UBERON:0034874 respiratory air respiratory system air uberon multi organ part structure An multicellular anatomical structure that has subparts of multiple organs as a part. CARO:0020001 UBERON:0034921 anatomical cluster uberon cell cluster A cluster of cells, largely surrounded by a morphological boundary. CARO:0020002 FMA:62807 UBERON:0034922 uberon anatomical collection A collection of anatomical structures that are alike in terms of their morphology or developmental origin. UBERON:0034925 resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected uberon external soft tissue zone A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. UBERON:0034929 uberon zone of organ FMA:55268 UBERON:0034944 organ region with floating fiat boundary organ sector organ zonal region organ zone uberon gas in respiratory system Any portion of gas located in a part of the respiratory system. UBERON:0034947 respiratory gas respiratory system gas uberon epithelial layer of duct UBERON:0034969 duct epithelium ductal epithelium uberon future mouth FMA:293105 The primordial mouth region of the developing head. UBERON:0035804 primitive mouth primordial mouth uberon preplacodal ectoderm Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon ZFA:0007013 teleost_anatomy_curators uberon/phenoscape-anatomy external integument structure Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon amphibian_anatomy_curators uberon/phenoscape-anatomy digit plus metapodial segment A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis. UBERON:5002544 digit digit ( phalanges plus metapodial) plus soft tissue digit digitopodial subdivision digit ray this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit. uberon individual digit of digitopodial skeleton A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element. UBERON:5102544 digit digit skeleton this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials. uberon part of pathogen organism in vaccine YH 'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism. vaccine Many vaccines are developed to protect against infectious pathogens. Many vaccines are also being developed against some diseases such as cancer and autoimmune diseases. Vaccine is developed against a disease. Allergy. YH, BP, BS, MC, LC, XZ, RS MeSH: D014612 a role that inheres in a prepared material entity that is designed to induce protection or treament for a diease or infection in vivo. A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine. vaccination a process of administering substance in vivo that involves in adding a vaccine into a host (e.g., human) in vivo with the intent to invoke a protective or therapeutic adaptive immune response. YH, BP a medical intervention that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intent to invoke an adaptive immune response. vaccine administration ACAM2000 Smallpox (Vaccinia) Vaccine, Live YH CVX: 75 Trade Name: ACAM2000 ActHIB Product Name: Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) YH PMID: PMID: 1735812 PMID: 1517908 Trade Name: ActHIB CVX: 48 Adacel Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed CVX: 20 Trade Name: Adacel CVX: 115 YH Afluria Product Name: Influenza Virus Vaccine CVX: 141 Trade Name: Afluria CVX: 140 WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf YH Bacillus anthracis vaccine YH A vaccine that protects against Bacillus anthrax that causes anthrax. anthrax vaccine MeSH: D022122 Biothrax Product Name: Anthrax Vaccine Adsorbed YH CVX: 24 Trade Name: Biothrax Boostrix Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed CVX: 115 YH CVX: 20 Trade Name: Boostrix Comvax Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant) Trade Name: Comvax YH PMID: CVX: 51 Daptacel Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed YH Trade Name: DAPTACEL CVX: 106 Vaccine components see http://www.vaccinesafety.edu/components-DTaP.htm CVX: 20 DECAVAC Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Trade Name: DECAVAC CVX: 113 MenHibrix YH a vaccine for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups C and Y and Haemophilus influenzae type b. MENHIBRIX is approved for use in children 6 weeks of age through 18 months of age. Diphtheria and Tetanus Toxoids Adsorbed USP by Sanofi Pasteur Inc Product Name: Diphtheria & Tetanus Toxoids Adsorbed YH CVX: 28 Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd Product Name: Diphtheria & Tetanus Toxoids Adsorbed YH adenovirus vaccine A viral vaccine that protects against infection of an adenovirus. YH, SGS FluLaval Product Name: Influenza Virus Vaccine, Trivalent, Types A and B YH Trade Name: FluLaval CVX: 141 FluMist Product Name: Influenza Virus Vaccine, Live, Intranasal CVX: 111 YH WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf Trade Name: FluMist Fluarix Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: Fluarix YH CVX: 140 Fluvirin Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: Fluvirin CVX: 140 CVX: 141 YH Fluzone Product Name: Influenza Virus Vaccine, Trivalent, Types A and B CVX: 141 YH CVX: 140 CVX: 144 Trade Name: Fluzone Gardasil Product Name: Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine CVX: 62 Trade Name: Gardasil YH Havrix Product Name: Hepatitis A Vaccine, Inactivated Trade Name: Havrix YH CVX: 83 CVX: 52 Neisseria meningitidis vaccine A bacterial vaccine that prevents Neisseria meningitidis infection. Meningococcal vaccine MeSH: D022401 YH IPOL Product Name: Poliovirus Vaccine Inactivated (Monkey Kidney Cell) PMID: YH Trade Name: IPOL CVX: 10 Imovax Rabies (USA) Product Name: Rabies Vaccine YH CVX: 18 Trade Name: Imovax Infanrix Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed YH CVX: 20 Trade Name: Infanrix Influenza Virus Vaccine H5N1 (Sanofi Pasteur Inc) Product Name: Influenza Virus Vaccine, H5N1 (for National Stockpile) YH WEB: http://atomicnewsreview.org/2009/10/22/approval-for-the-arepanrix%E2%84%A2-gsk-vaccine-in-canada/ JE-Vax Product Name: Japanese Encephalitis Virus Vaccine Inactivated YH CVX: 39 Trade Name: JE-Vax Kinrix Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine Trade Name: KINRIX CVX: 130 YH Menactra Product Name: Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine YH WEB: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm176044.htm Trade Name: Menactra Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine CVX: 114 Meruvax II Product Name: Rubella Virus Vaccine Live CVX: 06 Trade Name: Meruvax II YH Fluzone High-dose Product Name: Influenza Virus Vaccine, Trivalent, Types A and B an influenza vaccine that is similar to Fluzone but has high dose. YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf CVX: 140 CVX: 141 Trade Name: Fluzone CVX: 144 Pediarix Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined CVX: 110 Trade Name: Pediarix YH PedvaxHIB Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) PMID: CVX: 49 YH Trade Name: PedvaxHIB PMID: 2791073 Pentacel Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine YH CVX: 120 Trade Name: Pentacel Pneumovax 23 (USA) Product Name: Pneumococcal Vaccine, Polyvalent CVX: 33 Trade Name: Pneumovax 23 YH Prevnar (USA) Product Name: Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) YH Trade Name: Prevnar CVX: 100 ProQuad Product Name: Measles, Mumps, Rubella and Varicella Virus Vaccine Live A Measles-Mumps-Rubella-Vericella vaccine that is live and manufactured by Merck & Co, Inc. YH Trade Name: ProQuad WEB: http://www.merck.com/product/usa/pi_circulars/p/proquad/proquad_pi.pdf CVX: 94 Fluzone intradermal Trade Name: Fluzone intradermal WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf YH mineral salt vaccine adjuvant a vaccine adjuvant that is formed as a mineral salt. SGS, YH CVX: 119 RabAvert Product Name: Rabies Vaccine WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf CVX: 18 Trade Name: RabAvert YH Adenovirus Type 4 and Type 7 Vaccine, Live, Oral YH, SGS CVX: 143; UMLS_CUI: C0695130; SNOMEDCT: 442561000 RotaTeq Product Name: Rotavirus Vaccine, Live, Oral, Pentavalent Trade Name: RotaTeq YH CVX: 116 TENIVAC Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Trade Name: TENIVAC TYPHIM Vi Product Name: Typhoid Vi Polysaccharide Vaccine CVX: 101 Trade Name: TYPHIM Vi YH Tetanus and Diphtheria Toxoids Adsorbed by MA Biologic Lab Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Tripedia Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Trade Name: Tripedia CVX: 20 YH Twinrix Product Name: Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine CVX: 104 YH Trade Name: Twinrix Varivax Product Name: Varicella Virus Vaccine Live Trade Name: Varivax YH CVX: 21 Vivotif (USA) Product Name: Typhoid Vaccine Live Oral Ty21a CVX: 25 Trade Name: Vivotif YH YF-Vax Product Name: Yellow Fever Vaccine Trade Name: YF-Vax YH http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf CVX: 37 Yellow fever virus vaccine A viral vaccine that protects against infection with Yellow fever virus. MeSH: D022341 YH Zostavax Product Name: Zoster Vaccine, Live, (Oka/Merck) CVX: 121 YH Trade Name: Zostavax vaccine adjuvant role an adjuvant role that inheres in a vaccine component which is added as part of a vaccine and induces enhanced adaptive immune response to the vaccine antigen. YH bacterial vaccine A vaccine that targets against a bacterial disease. MeSH: D001428 YH vaccine organism live attenuated a virulence of vaccine organism that shows an attenuated pheontype of the organism as the major component of a vaccine. YH vaccine component YH a processed material that is output of the vaccine preparation and part of a vaccine. vaccine ingredient cardinal part of vaccine USA licensed human vaccine role YH a USA licensed vaccine role that inheres ina vaccine approven to be by the US FDA to be used for humans in the USA. vaccine contraindication contraindication for vaccination YH A vaccine contraindication is a contraindication that increases the risks of a vaccination. vaccine organism inactivated an organismal quality of a whole organism vaccine where the whole organism is inactivated/killed and lacks the capability of replication. vaccine organism killed YH hypersensitivity to chicken product YH hypersensitivity to chicken egg YH pgp.LAMP-1 DNA vaccine plasmid Rebecca Racz, Yongqun He PMID: 19356616 A DNA vaccine plasmid vector that has the plasmid label pgp.LAMP-1. This plasmid has a CMV promoter and contains the human lysosomal-associated membrane protein-1 signal sequence. vaccine function YH, MC, XZ, and AR PERSPN: Oliver He: There has been hot discussion about whether we use 'vaccine function' or 'vaccine role'. Vaccine role may not be the good term to use. Vaccine is designed to be 'vaccine', so it should be vaccine function. One special case is cowpox virus. The cowpox virus can be mixed with some liquid like water and used as a smallpox vaccine. In this case, people often say: the cowpox virus has a 'vaccine role'. However, the cowpox virus vaccine is a processed material of a mix of the virus with water. The virus is a virus, it is not a vaccine per se. Therefore, vaccine role may not be an accurate term. vaccine function is a function that inheres in a vaccine that induces protective immune response against a disease. It is realized in the immunization process in the host. company YH injection site a medical intervention site that is used for injection of a substance. YH, SS, ZX intramuscular route a route of administration that inject the material(such as vaccines, allergens) directly into a muscle. I.M. YH,YL intramuscular injection route intranasal route YH rounte of administration that located in nose. I.N. intranasal route by spray YH vaccine additive role Page 73, Chapter 6, Vaccine, 5th Edition. EXPERT CONSULT by Plotkin SA., et. al. 2008 a role inheres in a material entity, that has been added into a vaccine's formulation by the manufacture for a specific purpose. For example: adjuvant to enhance the effect of immunogen, perservatives, stablizers and those materials added for affecting PH and isotonicity. YL,YH Varicella-zoster virus live vaccine SNOMEDCT: 412530002; ULMS_CUI: C0770687 a Varicella-zoster virus vaccine that is live attenuated. YH pathogen organism component in vaccine YH a vaccine component that originates from an organism such as a pathogen or a modified organism. polyvalent pneumococcal vaccine YH WEB: http://www.who.int/vaccines/en/pneumococcus.shtml a pneumococcal vaccine that is formed using polyvalent polysaccharides The most common form of the polyvalent pneumococcal vaccine is called the protein-polysaccharide combinations which is known as conjugate vaccines and contain 7–11 selected polysaccharides bound to a protein carrier. The protein-polysaccharide combinations are able to induce a T-cell dependent immune response. These vaccines are likely to be protective even in children under two years of age, and may reduce pneumococcal transmission through a herd effect. vaccinia virus vaccine WEB: http://en.wikipedia.org/wiki/Vaccinia a Smallpox virus vaccine that uses vaccinia virus YH Vaccinia virus is well known for its role as a vaccine that helped eradicate the smallpox disease, making it the first human disease to be successfully eradicated by science. DNA vaccine plasmid vector YH a vaccine component that is composed of a plasmid and used in the generation of a DNA vaccine. preventive vaccine function preventive vaccine function is a vaccine function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which protects against a specific disorder. prophylactic vaccine function YH protein of pathogen organism as vaccine component YH chicken ovalbumin egg protein allergen WEB: http://en.wikipedia.org/wiki/Ovalbumin a chicken egg protein allergen where the protein allergen is ovalbumin, the main protein found in egg write, making up 60-65% of the total protein. YH licensed human vaccine role YH a licensed vaccine role that is bears in a licensed human vaccine. immunization WEB: http://en.wikipedia.org/wiki/Immunization immunization is a processual entity that primes or modifies an adaptivie immune response to some antigens. YH, XZ, BP active immunization YH, XZ WEB: http://en.wikipedia.org/wiki/Immunization Active immunization is an immunization process that entails the introduction of a foreign molecule into the body, which causes the body itself to generate adaptive immunity against the target. vaccine immunization artificial active immunization is an active immunization that occurs when a person or animal is vaccinated with a specific vaccine. artificial active immunization WEB: http://en.wikipedia.org/wiki/Immunization YH, XZ induction of adaptive immune response to antigen YH, XZ induction of adaptive immune response to antigen is an active immunization process that results in induction of adaptive immune response to some antigens, for example, in a vaccine. disorder prevention disorder prevention is a processual entity that prevents a disorder that is the physical basis of a disease. YH, XZ disorder treatment disorder treatment is a processual entity that leads to treat a disorder that is the physical basis of a disease. YH, XZ modification of adaptive immune response to antigen modification of adaptive immune response to antigen is an active immunization process that results in modification of an adaptive immune response to some antigens, for example, in a therapeutic vaccine. YH, XZ Pox vaccine a viral vaccine against a disease caused by a virus belong to Poxviridae. subcutaneous route YH YL S.C. a route of administration that is loacted in the hypodermis (subcutaneous tissue) region. human vaccinee a vaccinee that is a human being human vaccinee population a population of human beings who are vaccinated. therapeutic vaccine function YH The therapeutic vaccine function is a function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which ameliorates a specific disorder. route of administration http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38114 YH,YL CDISC has a codelist: Rout of Administration. Desription from CDISC: The course by which a substance was administered in order to reach the site of action in the body. CDISC_SDTM_Route_of_Administration_Terminology http://en.wikipedia.org/wiki/Route_of_administration a path that is located in gross anatomical part of an organism (e.g., human) and is used for administering a vaccine, a drug, fluid, poison, or other substance into the body. http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66729 vaccine adjuvant a vaccine component that is chemical substance added to vaccine and enhance and direct immune response to protective antigen. Many of vaccine adjuvants cause a range of serious side-effects. YH immunization objective WEB: http://en.wikipedia.org/wiki/Immunization YH, XZ immunization objective is the specification of an objective to achieve immunization. vaccine preparation vaccine production vaccine generation vaccine preparation is a manufacturing process to produce a vaccine. YH, BP Canada licensed human vaccine role a Canada licensed vaccine role that indicates the vaccine is used for human YH viral vaccine A vaccine that targets against a viral disease. MeSH: D014765 YH vaccine role YH a role that inheres in a prepared material entity that is designed to induce protection or treatment for a disease or infection. vaccine component role a role that inheres in a material entity that becomes an ingredient of a vaccine. YH conjugate vaccine role a vaccine role that indicates the vaccine being a conjugate vaccine. YH licensed vaccine role YH licensed vaccine role is a regulation-assigned role that indicates that a vaccine obtains official approval for commercial production and selling on the market. Clostridium vaccine YH A bacterial vaccine that protects against infection with Clostridium spp. Clostridium tetani vaccine tetanus vaccine YH a Clostridium vaccine that protects against infection with Clostridium tetani that causes tenanus. Influenza virus vaccine MeSH: D007252; UMLS_CUI: C0021403; SNOMEDCT: 46233009 A viral vaccine that protects against infection with influenza virus. YH Influenza vaccine Hepatitis B virus vaccine MeSH: D017325 A viral vaccine that protects against infection with Hepatitis B virus. YH Hepatitis A virus vaccine YH MeSH: D022362 A viral vaccine that protects against infection with Hepatitis A virus. Rabies virus vaccine YH MeSH: D011819; SNOMEDCT: 333606008; UMLS_CUI:C0034496 A viral vaccine that protects against infection with Rabies virus. Smallpox virus vaccine A viral vaccine that protects against infection with Smallpox virus. YH MeSH: D012900 Measles virus vaccine MeSH: D008458 YH A viral vaccine that protects against infection with Measles virus. Measles vaccine Rotavirus vaccine A viral vaccine that protects against infection with Rotavirus. YH MeSH: D022243; UMLS_CUI: C0597418; SNOMEDCT: 116077000 Haemophilus vaccine A bacterial vaccine that protects against infection with Haemophilus. YH MeSH: D018073 Haemophilus influenzae serotype b vaccine Haemophilus b vaccine YH Poliovirus vaccine MeSH: D023321 YH A viral vaccine that protects against infection with Poliovirus. Japanese encephalitis virus vaccine Japanese encephalitis vaccine MeSH: D022321 A viral vaccine that protects against infection with Japanese encephalitis virus. YH human papillomavirus vaccine UMLS_CUI: C1512511; SNOMEDCT: 424519000 a vaccine against human papillomavirus infection YH Varicella-zoster virus vaccine UMLS_CUI: C0078048; SNOMEDCT: 108729007 a Herpesvirus vaccine that is used against Varicella-zoster virus infection. YH chickenpox virus vaccine Salmonella typhi vaccine typhoid vaccine a Salmonella vaccine against typhoid fever (or called typoid), caused by Salmonella enterica enterica, serovar Typhi. YH Streptococcus pneumoniae vaccine a Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases. YH WEB: http://www.who.int/vaccines/en/pneumococcus.shtml pneumococcal vaccine vaccine allergen disposition YH Herpesvirus vaccine A viral vaccine that protects against infection with Herpesvirus. YH MeSH: D022283 Measles-Mumps-Rubella vaccine MMR A Measles-Mumps vaccine that also protects against infection with Rubella virus. MMR is usually live attenuated. YH Diphtheria-Tetanus vaccine YH A Corynebacterium diphtheriae vaccine that also protect against infection with Clostridium tetani. Corynebacterium diphtheriae vaccine diphtheria vaccine YH A bacterial vaccine that protects against infection with Corynebacterium diphtheriae that causes Diphtheria. Measles-Mumps vaccine YH A Measles virus vaccine that also protects against infection with Mumps virus. Measles-Mumps-Rubella-Vericella vaccine YH A Measles-Mumps-Rubella vaccine that also protects against Vericella. Diphtheria-Tetanus-Pertussis vaccine DTP vaccine YH UMLS_CUI: C0012559; SNOMEDCT: 421245007 DTaP vaccine Haemophilus influenzae serotype b YH Diphtheria-Tetanus-Pertussis-Poliovirus vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine YH Hepatitis A&B vaccine YH Haemophilus b and Hepatitis B vaccine a viral vaccine against Hepatitis B virus and at the same time against bacterial H. influenzae serotype b. YH Papillomavirus vaccine MeSH: D053918 YH A viral vaccine that protects against infection with Papillomavirus. Salmonella vaccine YH A bacterial vaccine that protects against infections by various Salmonella species. MeSH: D022562 Streptococcal vaccine YH Streptococcus vaccine A bacterial vaccine that prevents streptococcal infections. MeSH: D022541 USA licensed vaccine role YH a licensed vaccine role that indicates the vaccine occurs in USA. vaccine preservative antimicrobial agent in vaccine YH vaccine stabilizer a vaccine additive that helps to protect the vaccine from adverse conditions such as the freeze-drying process (for those vaccines that are freeze-dried) or heat. Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 75. YH vaccine residual Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. Although no all manufacturing residuals may be identified and quantified, their presence and quantity is assumed to be constant because of the constancy of the manufacturing process. a vaccine component that remains from the vaccine manufacturing process. YH cell culture residual in vaccine a vaccine residual that is generatead from cell culture for vaccine preparation. Examples include: antibiotics, sensitizing substances, bacterial and cellular residuals, and adventitious agents. YH Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78-81. Canada licensed vaccine role YH a licensed status that occurs in Canada. aluminum vaccine adjuvant YH a mineral salt vaccine adjuvant that is composed of aluminum salt. Aluminum vaccine adjuvant is a vaccine adjuvant that is composed of some aluminum compound. vaccine preservative role P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al. The CFR requires that, with certain defined exceptions, preservatives must be added to mulitdose vials of vaccine. (P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al.) YH,YL a role inhers in a vaccine component that when added into a vccine formmulation, it can prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during administrating process or the manufacturing process. oral route YH a route of administration that located in the mouth intradermal route intradermal injection route YH,YL a route of administration that inject the material(such as vaccines, allergens) into the skin itself. I.D. phenol vaccine preservative YH age at vaccination Age at vaccination is the age of an experiment animal at the time of vaccination. YH vaccine allergen WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf vaccine allergen is a material entity that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals who has been vaccinated with a vaccine. YH, ZX chicken egg protein allergen chicken egg protein allergen is a vaccine allergen that is composed of chicken egg protein. YH, ZX, MC latex vaccine allergen YH, ZX bovine albumin cell culture residual in vaccine a cell culture residual in vaccine that is bovine albumin. YH, ZX vaccine residual protein from cell culture YH a cell culture residual in vaccine that is residual protein from cell culture. sorbitol vaccine stabilizer YH, YL glucitol Sorbitol, also known as glucitol, is a sugar alcohol that the human body metabolizes slowly. It can be obtained by reduction of glucose, changing the aldehyde group to a hydroxyl group. Sorbitol is found in apples, pears, peaches, and prunes. It is synthesized by sorbitol-6-phosphate dehydrogenase, and converted to fructose by succinate dehydrogenase and sorbitol dehydrogenase. Succinate dehydrogenase is an enzyme complex that participates in the citric acid cycle. (wikipedia) a vaccine stabilizer that is specifically made by sorbitol. xanthan gum vaccine ajuvant PMID: 19608270 YL yeast protein cell culture residual in vaccine YH a cell culture residual in vaccine that is yeast protein. Diphtheria-Tetanus-Poliovirus vaccine pBLUESCRIPT DNA vaccine plasmid Rebecca Racz, Yongqun He Davidson College - pBLUESCRIPT: Plasmids and Phages Combine For pBluescript [http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/Keogh/plasmids.html] The plasmid length is: 2961 Derived from pUC vectors; cross between phages and plasmids and therefore in a special category called "phagemids" (Davidson College - pBLUESCRIPT) A DNA vaccine plasmid vector that has the plasmid label pBLUESCRIPT. DNAVaxDB Plasmid ID: 180 nkCMVint DNA vaccine plasmid DNAVaxDB Plasmid ID: 181 PMID: 9234529 A DNA vaccine plasmid vector that has the plasmid label nkCMVint. Rebecca Racz, Yongqun He A pUC-18-based plasmid; also contains intron A and an SV40 polyadenylation termination signal sequence. It has a CMV promoter. Flublok Yongqun He Trade Name: Flublok Flucelvax Yongqun He Trade Name: Flucelvax FluMist Quadrivalent YH Fluarix Quadrivalent YH Tetanus Toxoid (for Boost use Only) by Sanofi Pasteur Inc WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf YH a tetanus vaccine manusfactured by Sanofi Pasteur Inc. that is only for booster use (not recommended for primary immunization) viral vaccine organism live attenuated YH a live attenuated quality of a virus vaccine strain. Agriflu CVX: 140 YH vaccine organism viability vaccine viability is a viability of a vaccine organism. YH, ZX intramuscular vaccination a vaccination that occurs in the intramuscular route. YH, YL Prevnar 13 ZX VIOLIN Vaccine ID: 1114 CVX: 133 Menveo VIOLIN Vaccine ID: 1113 CVX: 136 capsular polysaccharide of pathogen organism as vaccine component YH polysaccharide of pathogen organism as vaccine component YH vaccine host role a role of host that contains vaccine. It is a role that inheres in an organism that is the target of a vaccine administration (vaccination process). YH, ZX synthetic vaccine adjuvant YH, SGS A vaccine aduvant that contains synthetic material. vaccinee vaccinated organism YH, YL, MC an organism that is vaccinated with a vaccine vaccine target specification The objective that intends to produce vaccine via the vaccine preparation process. YH intradermal vaccination vaccination process that occurs in intradermal route. YL oral vaccination YL vaccination process that occurs in oral route. subcutaneous vaccination YL vaccination process that occurs in the subcutaneous route vaccine stabilizer role YL a role inheres in vaccine component when added into vaccine's formulation, it tends to inhibit the reaction between two or more other vaccine substances in the final vaccine formulation; it also helps to protect the vaccine from adverse conditions such as the freeze-drying process or heat. sugar vaccine stabilizer YH, YL a vaccine stabilizer that is specifically made by a sugar. vaccine conjugate protein The conjugate protein is a part of a conjugate vaccine and acts as a carrier protein that is covalently attached to a vaccine antigen with poor antigenicity (e.g., a polysaccharide). A conjugate protein is able to induce T-cell-dependent immune responses and stimulate the production of immune memory. YL,YH vaccine conjugate role YL role inheres in a material eneitity that union itself chemically with a relative weak vaccine antigen to form a new whole that can create an effective miinuogen. The percutaneous route YL epicutaneous (application onto the skin), e percutaneous vaccination Administration of a drug by the way of absorption through the skin, usually for systemic action. The route allows sustained therapeutic plasma drug levels and avoids first pass effect. Simplicity of administration tends to result in high patient compliance. YL Rubella virus vaccine MeSH: D012411 A viral vaccine that protects against infection with Rubella virus. YH Engerix-B CVX: 08 YH, ZX CVX: 44 Product Name: Hepatitis B Vaccine (Recombinant) Trade Name: Engerix-B Hiberix CVX: 48 YH, ZX Trade Name: Hiberix Menomune A/C/Y/W-135 todo: Polysaccharide YH, ZX Trade Name: Menomune A/C/Y/W-135 Recombivax HB todo: Recombinant protein CVX: 08 CVX: 44 CVX: 43 YH, ZX Trade Name: Recombivax HB Rotarix todo: Live virus YH, ZX ROTARIX Trade Name: Rotarix Vaqta todo: Killed virus Trade Name: Vaqta VAQTA YH, ZX Ixiaro YH, ZX VIOLIN Vaccine ID: 741 CVX: 134 Cervarix CVX: 118 YH, ZX VIOLIN Vaccine ID: 740 Haemophilus influenzae vaccine Haemophilus influenzae A vaccine that protects against Haemophilus influenzae. YH, ZX nose structure *Subdivision of face which consists of the nasal skeleton, nasal septum and nasal cavity. 1a: The part of the face that bears the nostrils and covers the anterior part of the nasal cavity; broadly: this part together with the nasal cavity.n1b: The anterior part of the head at the top or end of the muzzle: snout, proboscis.n2: The vertebrate olfactory organ. 1a: The part of the face that bears the nostrils and covers the anterior part of the nasal cavity; broadly: this part together with the nasal cavity.n1b: The anterior part of the head at the top or end of the muzzle: snout, proboscis.n2: The vertebrate olfactory organ.[accessedResource: BTO:0000840][accessDate: 05-04-2011] 1a: The part of the face that bears the nostrils and covers the anterior part of the nasal cavity; broadly: this part together with the nasal cavity.nb: The anterior part of the head at the top or end of the muzzle: snout, proboscis.n2. The vertebrate olfactory organ. AAO:0000334 Any sense organ (FBbt:00005155) that functions in (some) detection of chemical stimulus involved in sensory perception (GO:0050907). Any sense organ (FBbt:00005155) that functions in (some) detection of chemical stimulus involved in sensory perception (GO:0050907).[accessedResource: FBbt:00005157][accessDate: 05-04-2011] Any sense organ (FBbt:00005155) that has function 'detection of chemical stimulus involved in sensory perception (GO:0050907)'. BTO:0000840 EHDAA:1502 EMAPA:16542 EV:0100037 FBbt:00005157 FMAID:46472 James Malone MA:0000281 MFO:0003640 Nose[accessedResource: FMAID:46472][accessDate: 05-04-2011] SAEL:72 TAO:0001149 XAO:0000201 XAO:0003033 ZFA:0001149 chemosensory sensory organ chemosensory sensory organ[accessedResource: FBbt:00005157][accessDate: 05-04-2011] nose olfactory system olfactory system[accessedResource: TAO:0001149][accessDate: 05-04-2011] ready for release pending final vetting axiom holds for all times Intercell Biomedical Acambis, Inc YH http://www.acambis.com/ Berna Biotech, Ltd http://www.crucell.com/ YH BioPort Corp YH http://www.bioport.com/ CSL Limited http://www.csl.com.au/ YH GlaxoSmithKline Biologicals YH http://www.gsk-bio.com/english/index.html ID Biomedical Corp of Quebec YH http://www.ctidirectory.com/search/company.cfm?company=129584 Massachusetts Public Health Biologic Lab YH MedImmune Vaccines, Inc http://www.medimmune.com/ YH Merck & Co, Inc http://www.merck.com/ YH Merck Sharp & Dohme Corp. Novartis Vaccines and Diagnostics http://www.novartis.com/about-novartis/our-businesses/vaccines-diagnostic.shtml YH Research Foundation for Microbial Diseases of Osaka University http://read.jst.go.jp/public/cs_kkn_004EventAction.do?action5=event&lang_act5=E&kcd1_act5=9535000000&judge_act5=2 YH Sanofi Pasteur Limited YH http://www.sanofipasteur.com Sanofi Pasteur, Inc YH http://www.sanofipasteur.us Aventis Pasteur Inc. Wyeth Pharmaceuticals Inc YH http://www.wyeth.com/ Sanofi Pasteur, SA YH http://www.sanofipasteur.co.za/ Merck Frosst YH, ZX http://www.merckfrosst.ca/ Novartis YH Aqua Health http://www.novartis.com/ Vical, Inc. http://www.vical.com/ has_specified_input has_specified_input 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works. PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Coutot A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. PERSON: Alan Ruttenberg has_specified_input see is_input_of example_of_usage has_specified_output has_specified_output PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Courtot A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. PERSON: Alan Ruttenberg has_specified_output