{ "Version": 80, "ExpressionProfiles": [ { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP3A4", "Category": "Standard European Male for DDI", "Parameters": [ { "Path": "CYP3A4|Reference concentration", "Value": 4.32, "Unit": "µmol/l" }, { "Path": "CYP3A4|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "CYP3A4|t1/2 (liver)", "Value": 36.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", "Value": 0.0041682898325 }, { "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", "Value": 0.00078691079081 }, { "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", "Value": 0.0053603428126 }, { "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression", "Value": 0.00042695753798 }, { 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"Unit": "µmol/l" }, { "Path": "AADAC|Relative expression in blood cells", "Value": 3.9102564103E-05 }, { "Path": "AADAC|Relative expression in plasma", "Value": 3.9102564103E-05 }, { "Path": "AADAC|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "AADAC|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|AADAC|Relative expression", "Value": 4.8717948718E-05 }, { "Path": "Organism|Brain|Intracellular|AADAC|Relative expression", "Value": 3.9743589744E-05 }, { "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression", "Value": 0.0011923076923 }, { "Path": "Organism|Heart|Intracellular|AADAC|Relative expression", "Value": 0.0026602564103 }, { "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression", "Value": 5.7051282051E-05 }, { "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|AADAC|Relative expression", "Value": 0.0269230769 }, { "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression", "Value": 0.00020833333333 }, { "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression", "Value": 0.1474358974 }, { "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression", "Value": 0.00037115384615 }, { "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression", "Value": 0.0775641026 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" }, { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP3A5", "Category": "Standard European Male for DDI", "Parameters": [ { 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expression", "Value": 0.5379310345 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A5|Relative expression", "Value": 0.5379310345 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A5|Relative expression", "Value": 0.5379310345 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A5|Relative expression", "Value": 0.5379310345 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome", "Ontogeny": { "Name": "CYP3A5" } }, { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP2C9", "Category": "Standard European Male for DDI", "Parameters": [ { "Path": "CYP2C9|Reference concentration", "Value": 3.84, "Unit": "µmol/l" }, { "Path": "CYP2C9|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "CYP2C9|t1/2 (liver)", "Value": 104.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|CYP2C9|Relative expression", "Value": 0.00039687350455 }, { "Path": 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"Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2C9|Relative expression", "Value": 0.1199553358 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2C9|Relative expression", "Value": 0.1199553358 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome", "Ontogeny": { "Name": "CYP2C9" } }, { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP1A2", "Category": "Standard European Male for DDI", "Parameters": [ { "Path": "CYP1A2|Reference concentration", "Value": 1.8, "Unit": "µmol/l" }, { "Path": "CYP1A2|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "CYP1A2|t1/2 (liver)", "Value": 39.0, "Unit": "h" }, { "Path": "Organism|Gonads|Intracellular|CYP1A2|Relative expression", "Value": 0.00029559748428 }, { "Path": "Organism|Kidney|Intracellular|CYP1A2|Relative expression", "Value": 4.4025157233E-06 }, { "Path": "Organism|Liver|Pericentral|Intracellular|CYP1A2|Relative expression", "Value": 1.0 }, { "Path": 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"Path": "Organism|Kidney|Intracellular|ABCB1|Relative expression", "Value": 1.0 }, { "Path": "Organism|LargeIntestine|Intracellular|ABCB1|Relative expression", "Value": 0.1562867215 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCB1|Relative expression", "Value": 0.1562867215 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCB1|Relative expression", "Value": 0.1562867215 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCB1|Relative expression", "Value": 0.1562867215 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCB1|Relative expression", "Value": 0.1562867215 }, { "Path": "Organism|Liver|Pericentral|Intracellular|ABCB1|Relative expression", "Value": 0.2702702703 }, { "Path": "Organism|Liver|Periportal|Intracellular|ABCB1|Relative expression", "Value": 0.2702702703 }, { "Path": "Organism|Lung|Intracellular|ABCB1|Relative expression", "Value": 0.0927144536 }, { "Path": "Organism|Muscle|Intracellular|ABCB1|Relative expression", "Value": 0.0180963572 }, { "Path": "Organism|Pancreas|Intracellular|ABCB1|Relative expression", "Value": 0.0200940071 }, { "Path": "Organism|SmallIntestine|Intracellular|ABCB1|Relative expression", "Value": 0.3960047004 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCB1|Relative expression", "Value": 0.3960047004 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression", "Value": 0.3960047004 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression", "Value": 0.3960047004 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression", "Value": 0.3960047004 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression", "Value": 0.3960047004 }, { "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression", "Value": 0.1047003525 }, { "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression", "Value": 0.0367802585 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OATP1B1", "Category": "Standard European Male for DDI", "Parameters": [ { "Path": "OATP1B1|Reference concentration", "Value": 1.0, "Unit": "µmol/l" }, { "Path": "OATP1B1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OATP1B1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", "Value": 0.00014166666667 }, { "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", "Value": 0.0141666667 }, { "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", "Value": 0.0008253968254 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", "Value": 4.0079365079E-05 }, { "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", "Value": 0.00064682539683 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": 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