{
  "Version": 80,
  "ExpressionProfiles": [
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP3A4",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "CYP3A4"
      }
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "AADAC",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
    },
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "P-gp",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "Organism|Bone|Intracellular|P-gp|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Brain|Intracellular|P-gp|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Heart|Intracellular|P-gp|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Lung|Intracellular|P-gp|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "P-gp|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "P-gp|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "P-gp|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "TransportType": "Efflux",
      "Expression": [
        {
          "Name": "Bone",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainInterstitialToPlasma",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainTissueToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Lung",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Muscle",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pancreas",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Skin",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Spleen",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "BloodCells",
          "TransportDirection": "EffluxBloodCellsToPlasma"
        },
        {
          "Name": "VascularEndothelium",
          "TransportDirection": "EffluxInterstitialToPlasma"
        }
      ],
      "Ontogeny": {
        "Name": "P-gp",
        "Table": {
          "Name": "TableFormula",
          "Percentile": 0.0,
          "DistributionMetaData": [
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              "Mean": 1E-14,
              "Deviation": 1.6,
              "Distribution": "LogNormal"
            },
            {
              "Mean": 1.915059E-05,
              "Deviation": 1.6,
              "Distribution": "LogNormal"
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            {
              "Mean": 5.486795E-05,
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            {
              "Mean": 0.0001571905,
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            {
              "Mean": 0.0004502473,
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            {
              "Mean": 0.001288958,
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            {
              "Mean": 0.00368424,
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            {
              "Mean": 0.01048397,
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              "Distribution": "LogNormal"
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            {
              "Mean": 0.02946235,
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            {
              "Mean": 0.0800178,
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              "Distribution": "LogNormal"
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              "Mean": 0.1994918,
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            {
              "Mean": 0.4165768,
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              "Mean": 0.6716791,
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              "Mean": 0.943803,
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              "Mean": 0.9796414,
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              "Mean": 0.992799,
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            {
              "Mean": 0.9974749,
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            {
              "Mean": 0.9991173,
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            {
              "Mean": 0.9996917,
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          ],
          "XName": "Postmenstrual age",
          "XDimension": "Age in years",
          "XUnit": "year(s)",
          "YName": "P-gp",
          "YDimension": "Fraction",
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            {
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            {
              "X": 1.416667,
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              "RestartSolver": false
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            {
              "X": 1.5,
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              "RestartSolver": false
            },
            {
              "X": 1.583333,
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              "RestartSolver": false
            },
            {
              "X": 1.666667,
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              "RestartSolver": false
            },
            {
              "X": 1.75,
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              "RestartSolver": false
            },
            {
              "X": 1.833333,
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              "RestartSolver": false
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            {
              "X": 3.333333,
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              "RestartSolver": false
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          ]
        }
      }
    },
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "OATP1B1",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        }
      ],
      "TransportType": "Influx",
      "Expression": [
        {
          "Name": "Bone",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainPlasmaToInterstitial",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainInterstitialToTissue",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Lung",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Muscle",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pancreas",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Skin",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Spleen",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "BloodCells",
          "TransportDirection": "InfluxPlasmaToBloodCells"
        },
        {
          "Name": "VascularEndothelium",
          "TransportDirection": "InfluxPlasmaToInterstitial"
        }
      ]
    },
    {
      "Type": "OtherProtein",
      "Species": "Human",
      "Molecule": "ATP1A2",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        }
      ],
      "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT1A4",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "UGT1A4|Reference concentration",
          "Value": 2.32,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "UGT1A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "UGT1A4"
      }
    },
    {
      "Type": "OtherProtein",
      "Species": "Human",
      "Molecule": "GABRG2",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "GABRG2|Reference concentration",
          "Value": 1.04099689,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "GABRG2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "GABRG2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|GABRG2|Relative expression",
          "Value": 1.0
        }
      ],
      "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP3A4",
      "Category": "Japanese (Yasui studies)",
      "Parameters": [
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 3.4842311024,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "CYP3A4"
      }
    }
  ],
  "Individuals": [
    {
      "Name": "European (P-gp modified, CYP3A4 36 h)",
      "Seed": 17189110,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)",
        "AADAC|Human|European (P-gp modified, CYP3A4 36 h)",
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "OATP1B1|Human|European (P-gp modified, CYP3A4 36 h)",
        "ATP1A2|Human|European (P-gp modified, CYP3A4 36 h)",
        "UGT1A4|Human|European (P-gp modified, CYP3A4 36 h)",
        "GABRG2|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Japanese (Yasui studies)",
      "Seed": -2063117500,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "Japanese_Population",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "ExpressionProfiles": [
        "CYP3A4|Human|Japanese (Yasui studies)",
        "AADAC|Human|European (P-gp modified, CYP3A4 36 h)",
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "OATP1B1|Human|European (P-gp modified, CYP3A4 36 h)",
        "ATP1A2|Human|European (P-gp modified, CYP3A4 36 h)",
        "UGT1A4|Human|European (P-gp modified, CYP3A4 36 h)",
        "GABRG2|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Alprazolam",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "Optimized",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.0799268917,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.233,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVivo",
                "Description": "PMID: 1880224"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 40.0,
              "Unit": "mg/l"
            },
            {
              "Name": "Reference pH",
              "Value": 7.0
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Optimized",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 7.6146060669,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 2.4,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "alpha-OH pathway",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 0.131,
              "Unit": "nmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 11745908"
              }
            },
            {
              "Name": "Km",
              "Value": 269.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 11745908"
              }
            },
            {
              "Name": "kcat",
              "Value": 0.8066945978,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 0.5461456402,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "4-OH pathway",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 2.23,
              "Unit": "nmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 11745908"
              }
            },
            {
              "Name": "Km",
              "Value": 704.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 11745908"
              }
            },
            {
              "Name": "kcat",
              "Value": 13.7322820855,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Cl",
          "Value": 1.0
        },
        {
          "Name": "Molecular weight",
          "Value": 308.765,
          "Unit": "g/mol"
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "Xanax_IR",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 12.1060809908,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.92,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "Solanax",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 35.8519725483,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.92,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    }
  ],
  "Protocols": [
    {
      "Name": "IV_0.25mg",
      "ApplicationType": "IntravenousBolus",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.25,
          "Unit": "mg"
        }
      ]
    },
    {
      "Name": "IV_4mg",
      "ApplicationType": "IntravenousBolus",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 4.0,
          "Unit": "mg"
        }
      ]
    },
    {
      "Name": "IV_1mg_1min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 1.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_0.5mg_2min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.5,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 2.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_2mg_2min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 2.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_1mg_30min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 30.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_1mg_2min_0.576mg_8h",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 1.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 2.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 0.576,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 8.0,
                  "Unit": "h"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "min",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "PO_0.5mg",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.5,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "PO_1mg",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "PO_2mg",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "IV_0.5mg_1min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.5,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 1.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "PO_0.8mg",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.8,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "PO_Fleishaker 1994 - Alprazolam 1 mg QID 4 days",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 1.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 4.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 1.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 15.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 4.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 3",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 1.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 5.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 4.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 4",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 1.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 10.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 4.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    }
  ],
  "Simulations": [
    {
      "Name": "Kroboth1988_IV_0.5mg",
      "Model": "4Comp",
      "ObservedData": [
        "Kroboth 1988 - 0.5 mg/2 min - Alprazolam - IV - 0.5 mg - Plasma - agg. (n=4)"
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Alprazolam|Intestinal permeability (transcellular)",
          "Value": 0.4575114982,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.2' on 2020-03-25 12:52"
          }
        },
        {
          "Path": "Events|IV_0.5mg_2min|Application_1|ProtocolSchemaItem|Infusion time",
          "Value": 2.0,
          "Unit": "min"
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
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        {
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        },
        {
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        },
        {
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        },
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        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
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        },
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          "Unit": "cm/min",
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        {
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
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        },
        {
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          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
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        },
        {
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        },
        {
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          "Value": 0.2587408658,
          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
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            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        },
        {
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        {
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        {
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        },
        {
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        },
        {
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        },
        {
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        },
        {
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        },
        {
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        },
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        },
        {
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        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
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        {
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        {
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        },
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        },
        {
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        },
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        },
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        },
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        },
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        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
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        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
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          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
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          "Value": 0.2587408658,
          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        },
        {
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          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
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        },
        {
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        },
        {
          "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        },
        {
          "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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      ],
      "OutputSelections": [
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      "OutputMappings": [
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          "Scaling": "Log",
          "Path": "Fleishaker1989_IV_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
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      "Individual": "European (P-gp modified, CYP3A4 36 h)",
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              "MoleculeName": "CYP3A4"
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            {
              "Name": "Glomerular Filtration-GFR",
              "SystemicProcessType": "GFR"
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          ],
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            "Name": "IV_1mg_1min"
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      "HasResults": true,
      "IndividualAnalyses": [
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          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
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              "Visible": true,
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              "DefaultLineStyle": "None",
              "Scaling": "Linear",
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            },
            {
              "Unit": "mg/l",
              "Dimension": "Concentration (molar)",
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          "Curves": [
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                "LegendIndex": 1
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              "Unit": "h"
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          ]
        },
        {
          "Parameters": [
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              "Name": "Start time",
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              "Unit": "h"
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            {
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                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
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          ]
        }
      ],
      "Parameters": [
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          "Path": "Alprazolam|Intestinal permeability (transcellular)",
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        },
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        },
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          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
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        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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        },
        {
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          "Unit": "cm/min",
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        },
        {
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        },
        {
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      ],
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      "OutputMappings": [
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          ],
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            },
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              "Name": "Lin 1988 - IV administration, Caucasian subjects - Alprazolam - IV - 0.5 mg - Plasma - agg. (n=14)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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    {
      "Name": "Smith1984_IV_1mg",
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              "Unit": "h"
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          ]
        },
        {
          "Parameters": [
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              }
            },
            {
              "Name": "Resolution",
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          ]
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      ],
      "Parameters": [
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        },
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        },
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        },
        {
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        },
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
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          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
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        {
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          "Unit": "cm/min",
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        },
        {
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        {
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
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            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        {
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          "Unit": "cm/min",
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        {
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          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
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        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
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        },
        {
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          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
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        },
        {
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          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
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        {
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          "Unit": "cm/min",
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        {
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          "Unit": "cm/min",
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      "OutputSelections": [
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        },
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        {
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        },
        {
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        },
        {
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        },
        {
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        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
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          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
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        },
        {
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          ],
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    {
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            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 48.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Alprazolam|Intestinal permeability (transcellular)",
          "Value": 0.4575114982,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.2' on 2020-03-25 12:52"
          }
        },
        {
          "Path": "Events|IV_2mg_2min|Application_1|ProtocolSchemaItem|Infusion time",
          "Value": 2.0,
          "Unit": "min"
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)"
      ],
      "OutputMappings": [
        {
          "Scaling": "Log",
          "Path": "Bertz1997_IV_2mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Bertz 1997 - 2 mg, young subjects - Alprazolam - IV - 2 mg - Plasma - agg. (n=25)"
        }
      ],
      "Individual": "European (P-gp modified, CYP3A4 36 h)",
      "Compounds": [
        {
          "Name": "Alprazolam",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
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          ],
          "Alternatives": [
            {
              "AlternativeName": "Optimized",
              "GroupName": "COMPOUND_INTESTINAL_PERMEABILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-alpha-OH pathway",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP3A4-4-OH pathway",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "Glomerular Filtration-GFR",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "IV_2mg_2min"
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "mg/l",
              "Dimension": "Concentration (molar)",
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              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Log",
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                "Color": "#0000FF",
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                "LineStyle": "None",
                "Symbol": "Circle"
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            }
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          "Name": "Time Profile Analysis",
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              "LegendSize": 8,
              "TitleSize": 16,
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        }
      ]
    },
    {
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      "ObservedData": [
        "Lin 1988 - Oral administration, Caucasian subjects - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=14)",
        "Schmith 1991 - Normal subjects 0.5 mg - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=12)"
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      "Solver": {},
      "OutputSchema": [
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          "Parameters": [
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              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
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              "Value": 20.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 36.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Events|PO_0.5mg|Xanax_IR|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
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        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)"
      ],
      "OutputMappings": [
        {
          "Scaling": "Log",
          "Path": "PO_0.5mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Lin 1988 - Oral administration, Caucasian subjects - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=14)"
        },
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            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        },
        {
          "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
          "Value": 0.2587408658,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 3.4' on 2020-03-25 13:19"
          }
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)"
      ],
      "OutputMappings": [
        {
          "Scaling": "Log",
          "Path": "PO_Fleishaker1994|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Fleishaker 1994 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=20)"
        }
      ],
      "Individual": "European (P-gp modified, CYP3A4 36 h)",
      "Compounds": [
        {
          "Name": "Alprazolam",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "Optimized",
              "GroupName": "COMPOUND_INTESTINAL_PERMEABILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-alpha-OH pathway",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP3A4-4-OH pathway",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "Glomerular Filtration-GFR",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "PO_Fleishaker 1994 - Alprazolam 1 mg QID 4 days",
            "Formulations": [
              {
                "Name": "Solanax",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
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            {
              "Unit": "mg/l",
              "Dimension": "Concentration (molar)",
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  ],
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    {
      "Name": "Parameter Identification",
      "Simulations": [
        "Adams1984_IV_0.25mg",
        "Adams1984_IV_4mg",
        "Bertz1997_IV_2mg",
        "Fleishaker1989_IV_1mg",
        "Kroboth1988_IV_0.5mg",
        "Kroboth1988_IV_1mg_0.576mg_over8h",
        "Kroboth1988_IV_2mg",
        "Lin1988_IV_0.5mg",
        "PO_0.5mg",
        "PO_0.8mg",
        "PO_1mg",
        "PO_2mg",
        "Smith1984_IV_1mg",
        "Venkatakrishnan2005_IV_1mg"
      ],
      "Configuration": {
        "LLOQMode": "SimulationOutputAsObservedDataLLOQ",
        "RemoveLLOQMode": "Never",
        "CalculateJacobian": true,
        "Algorithm": {
          "Name": "Levenberg - Marquardt (MPFit)",
          "Properties": [
            {
              "Name": "ftol",
              "Value": 0.001,
              "Type": "Double"
            },
            {
              "Name": "xtol",
              "Value": 1E-06,
              "Type": "Double"
            },
            {
              "Name": "gtol",
              "Value": 1E-10,
              "Type": "Double"
            },
            {
              "Name": "stepfactor",
              "Value": 100.0,
              "Type": "Double"
            },
            {
              "Name": "maxiter",
              "Value": 200.0,
              "Type": "Double"
            },
            {
              "Name": "maxfev",
              "Value": 0.0,
              "Type": "Double"
            },
            {
              "Name": "epsfcn",
              "Value": 1E-09,
              "Type": "Double"
            }
          ]
        }
      },
      "OutputMappings": [
        {
          "Scaling": "Log",
          "Path": "Adams1984_IV_0.25mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Adams 1984 - 0.25 mg, Individual 1 - Alprazolam - IV - 0.25 mg - Plasma - indiv."
        },
        {
          "Scaling": "Log",
          "Path": "Adams1984_IV_0.25mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Adams 1984 - 0.25 mg, Individual 2 - Alprazolam - IV - 0.25 mg - Plasma - indiv."
        },
        {
          "Scaling": "Log",
          "Path": "Adams1984_IV_4mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Adams 1984 - 4 mg, Individual 1 - Alprazolam - IV - 4 mg - Plasma - indiv."
        },
        {
          "Scaling": "Log",
          "Path": "Adams1984_IV_4mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Adams 1984 - 4 mg, Individual 2 - Alprazolam - IV - 4 mg - Plasma - indiv."
        },
        {
          "Scaling": "Log",
          "Path": "Adams1984_IV_4mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Adams 1984 - 4 mg, Individual 3 - Alprazolam - IV - 4 mg - Plasma - indiv."
        },
        {
          "Scaling": "Log",
          "Path": "Bertz1997_IV_2mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Bertz 1997 - 2 mg, young subjects - Alprazolam - IV - 2 mg - Plasma - agg. (n=25)"
        },
        {
          "Scaling": "Log",
          "Path": "Fleishaker1989_IV_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Fleishaker 1989 - Treatment A (IV administration) - Alprazolam - IV - 1 mg - Plasma - agg. (n=42)"
        },
        {
          "Scaling": "Log",
          "Path": "Kroboth1988_IV_0.5mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Kroboth 1988 - 0.5 mg/2 min - Alprazolam - IV - 0.5 mg - Plasma - agg. (n=4)"
        },
        {
          "Scaling": "Log",
          "Path": "Kroboth1988_IV_1mg_0.576mg_over8h|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Kroboth 1988 - 1.0 mg/2 min, then 72 µg/hr for 8 hours - Alprazolam - IV - 1.576 mg - Plasma - agg. (n=4)"
        },
        {
          "Scaling": "Log",
          "Path": "Kroboth1988_IV_2mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Kroboth 1988 - 2.0 mg/2 min - Alprazolam - IV - 2 mg - Plasma - agg. (n=4)"
        },
        {
          "Scaling": "Log",
          "Path": "Lin1988_IV_0.5mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Lin 1988 - IV administration, Caucasian subjects - Alprazolam - IV - 0.5 mg - Plasma - agg. (n=14)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_0.5mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Lin 1988 - Oral administration, Caucasian subjects - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=14)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_0.5mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Schmith 1991 - Normal subjects 0.5 mg - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=12)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_0.8mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Yasui 1996 - Treatment with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=12)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_0.8mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Yasui 1998 - Alprazolam with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=10)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_0.8mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Yasui 2000 - Alprazolam with water - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=8)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Eller 1990 - Treatment C (fasting IR) - Alprazolam - PO - 1 mg - Plasma - agg. (n=21)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Friedman 1991 - Alprazolam group - Alprazolam - PO - 1 mg - Plasma - agg. (n=22)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Greenblatt 1988 - Alprazolam group - Alprazolam - PO - 1 mg - Plasma - agg. (n=12)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Greenblatt 1992 - Alprazolam group, Placebo first, Fluoxetine second - Alprazolam - PO - 1 mg - Plasma - agg. (n=11)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Greenblatt 1998b - Alprazolam alone (Trial A) - Alprazolam - PO - 1 mg - Plasma - agg. (n=7)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Greenblatt 2000 - Control - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Juhl 1984 - Healthy control group - Alprazolam - PO - 1 mg - Plasma - agg. (n=17)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Kaplan 1998 - Young - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Kirkwood 1991 - Men - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Schmider 1999 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=9)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Smith 1984 - Oral administration - Alprazolam - PO - 1 mg - Plasma - agg. (n=6)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Wennerholm 2005 - Figure 1 - Alprazolam - PO - 1 mg - Plasma - agg. (n=12)"
        },
        {
          "Scaling": "Linear",
          "Weight": 20.0,
          "Path": "PO_2mg|Organism|Kidney|Urine|Alprazolam|Fraction excreted to urine",
          "ObservedData": "Eberts 1980 - 14C-Alprazolam - Alprazolam - PO - 2 mg - Urine - agg. (n=6)"
        },
        {
          "Scaling": "Log",
          "Path": "PO_2mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Schmith 1991 - Normal subjects 2 mg - Alprazolam - PO - 2 mg - Plasma - agg. (n=12)"
        },
        {
          "Scaling": "Log",
          "Path": "Smith1984_IV_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Smith 1984 - IV administration - Alprazolam - IV - 1 mg - Plasma - agg. (n=6)"
        },
        {
          "Scaling": "Log",
          "Path": "Venkatakrishnan2005_IV_1mg|Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Venkatakrishnan 2005 - Alprazolam - Alprazolam - IV - 1 mg - Plasma - agg. (n=9)"
        }
      ],
      "IdentificationParameters": [
        {
          "Name": "Lipophilicity",
          "Scaling": "Linear",
          "LinkedParameters": [
            "Adams1984_IV_0.25mg|Alprazolam|Lipophilicity",
            "Adams1984_IV_4mg|Alprazolam|Lipophilicity",
            "Bertz1997_IV_2mg|Alprazolam|Lipophilicity",
            "Fleishaker1989_IV_1mg|Alprazolam|Lipophilicity",
            "Kroboth1988_IV_0.5mg|Alprazolam|Lipophilicity",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Alprazolam|Lipophilicity",
            "Kroboth1988_IV_2mg|Alprazolam|Lipophilicity",
            "Lin1988_IV_0.5mg|Alprazolam|Lipophilicity",
            "PO_0.5mg|Alprazolam|Lipophilicity",
            "PO_0.8mg|Alprazolam|Lipophilicity",
            "PO_1mg|Alprazolam|Lipophilicity",
            "PO_2mg|Alprazolam|Lipophilicity",
            "Smith1984_IV_1mg|Alprazolam|Lipophilicity",
            "Venkatakrishnan2005_IV_1mg|Alprazolam|Lipophilicity"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 2.0756837827,
              "Unit": "Log Units"
            },
            {
              "Name": "MinValue",
              "Value": 1.26,
              "Unit": "Log Units"
            },
            {
              "Name": "MaxValue",
              "Value": 2.19,
              "Unit": "Log Units"
            }
          ]
        },
        {
          "Name": "kcat",
          "Scaling": "Log",
          "UseAsFactor": true,
          "LinkedParameters": [
            "Adams1984_IV_0.25mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Adams1984_IV_0.25mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Adams1984_IV_4mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Adams1984_IV_4mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Bertz1997_IV_2mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Bertz1997_IV_2mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Fleishaker1989_IV_1mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Fleishaker1989_IV_1mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Kroboth1988_IV_0.5mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Kroboth1988_IV_0.5mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Kroboth1988_IV_2mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Kroboth1988_IV_2mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Lin1988_IV_0.5mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Lin1988_IV_0.5mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "PO_0.5mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "PO_0.5mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "PO_0.8mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "PO_0.8mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "PO_1mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "PO_1mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "PO_2mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "PO_2mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Smith1984_IV_1mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Smith1984_IV_1mg|Alprazolam-CYP3A4-4-OH pathway|kcat",
            "Venkatakrishnan2005_IV_1mg|Alprazolam-CYP3A4-alpha-OH pathway|kcat",
            "Venkatakrishnan2005_IV_1mg|Alprazolam-CYP3A4-4-OH pathway|kcat"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 1.0
            },
            {
              "Name": "MinValue",
              "Value": 0.1
            },
            {
              "Name": "MaxValue",
              "Value": 10.0
            }
          ]
        },
        {
          "Name": "Reference concentration",
          "Scaling": "Log",
          "LinkedParameters": [
            "PO_0.8mg|CYP3A4|Reference concentration"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 4.32,
              "Unit": "µmol/l"
            },
            {
              "Name": "MinValue",
              "Value": 1.0,
              "Unit": "µmol/l"
            },
            {
              "Name": "MaxValue",
              "Value": 10.0,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "Name": "GFR fraction",
          "Scaling": "Log",
          "LinkedParameters": [
            "Adams1984_IV_0.25mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Adams1984_IV_4mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Bertz1997_IV_2mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Fleishaker1989_IV_1mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Kroboth1988_IV_0.5mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Kroboth1988_IV_2mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Lin1988_IV_0.5mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "PO_0.5mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "PO_0.8mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "PO_1mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "PO_2mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Smith1984_IV_1mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|Kidney_pls_Kidney_ur|Alprazolam|Glomerular Filtration-GFR-Alprazolam|GFR fraction"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.5426032482
            },
            {
              "Name": "MinValue",
              "Value": 0.01
            },
            {
              "Name": "MaxValue",
              "Value": 10.0
            }
          ]
        },
        {
          "Name": "Dissolution shape - Xanax",
          "Scaling": "Linear",
          "IsFixed": true,
          "LinkedParameters": [
            "PO_0.5mg|Events|PO_0.5mg|Xanax_IR|Dissolution shape",
            "PO_1mg|Events|PO_1mg|Xanax_IR|Dissolution shape",
            "PO_2mg|Events|PO_2mg|Xanax_IR|Dissolution shape"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.92
            },
            {
              "Name": "MinValue",
              "Value": 0.1
            },
            {
              "Name": "MaxValue",
              "Value": 10.0
            }
          ]
        },
        {
          "Name": "Dissolution time (50% dissolved) - Xanax",
          "Scaling": "Log",
          "LinkedParameters": [
            "PO_0.5mg|Events|PO_0.5mg|Xanax_IR|Dissolution time (50% dissolved)",
            "PO_1mg|Events|PO_1mg|Xanax_IR|Dissolution time (50% dissolved)",
            "PO_2mg|Events|PO_2mg|Xanax_IR|Dissolution time (50% dissolved)"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 15.0,
              "Unit": "min"
            },
            {
              "Name": "MinValue",
              "Value": 1E-05,
              "Unit": "min"
            },
            {
              "Name": "MaxValue",
              "Value": 500.0,
              "Unit": "min"
            }
          ]
        },
        {
          "Name": "Dissolution shape - Solanax",
          "Scaling": "Linear",
          "IsFixed": true,
          "LinkedParameters": [
            "PO_0.8mg|Events|PO_0.8mg|Solanax|Dissolution shape"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.92
            },
            {
              "Name": "MinValue",
              "Value": 0.1
            },
            {
              "Name": "MaxValue",
              "Value": 10.0
            }
          ]
        },
        {
          "Name": "Dissolution time (50% dissolved) - Solanax",
          "Scaling": "Log",
          "LinkedParameters": [
            "PO_0.8mg|Events|PO_0.8mg|Solanax|Dissolution time (50% dissolved)"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 30.0,
              "Unit": "min"
            },
            {
              "Name": "MinValue",
              "Value": 1E-05,
              "Unit": "min"
            },
            {
              "Name": "MaxValue",
              "Value": 500.0,
              "Unit": "min"
            }
          ]
        },
        {
          "Name": "P_mucosa (interstitial<->intracellular)",
          "Scaling": "Log",
          "LinkedParameters": [
            "Adams1984_IV_0.25mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_0.25mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_4mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Bertz1997_IV_2mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Fleishaker1989_IV_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Kroboth1988_IV_2mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Lin1988_IV_0.5mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.5mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_0.8mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "PO_2mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Smith1984_IV_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)",
            "Adams1984_IV_0.25mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Adams1984_IV_4mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Bertz1997_IV_2mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Fleishaker1989_IV_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_0.5mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_1mg_0.576mg_over8h|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Kroboth1988_IV_2mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Lin1988_IV_0.5mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.5mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_0.8mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "PO_2mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Smith1984_IV_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)",
            "Venkatakrishnan2005_IV_1mg|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.00085,
              "Unit": "cm/min"
            },
            {
              "Name": "MinValue",
              "Value": 1E-10,
              "Unit": "cm/min"
            },
            {
              "Name": "MaxValue",
              "Value": 10.0,
              "Unit": "cm/min"
            }
          ]
        },
        {
          "Name": "Specific intestinal permeability (transcellular)",
          "Scaling": "Log",
          "LinkedParameters": [
            "Adams1984_IV_0.25mg|Alprazolam|Specific intestinal permeability (transcellular)",
            "Adams1984_IV_4mg|Alprazolam|Specific intestinal permeability (transcellular)",
            "Bertz1997_IV_2mg|Alprazolam|Specific intestinal permeability (transcellular)",
            "Fleishaker1989_IV_1mg|Alprazolam|Specific intestinal permeability (transcellular)",
            "Kroboth1988_IV_0.5mg|Alprazolam|Specific intestinal permeability (transcellular)",
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                "Y": "Venkatakrishnan 2005 - Alprazolam - Alprazolam - IV - 1 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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        },
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                "Name": "Adams 1984 - 4 mg, Individual 1 - Alprazolam - IV - 4 mg - Plasma - indiv.-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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                "Y": "Adams 1984 - 4 mg, Individual 1 - Alprazolam - IV - 4 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                "Name": "Fleishaker 1989 - Treatment A (IV administration) - Alprazolam - IV - 1 mg - Plasma - agg. (n=42)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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                "Name": "Kroboth 1988 - 1.0 mg/2 min, then 72 µg/hr for 8 hours - Alprazolam - IV - 1.576 mg - Plasma - agg. (n=4)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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              {
                "Name": "Kroboth 1988 - 2.0 mg/2 min - Alprazolam - IV - 2 mg - Plasma - agg. (n=4)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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                "Y": "Kroboth 1988 - 2.0 mg/2 min - Alprazolam - IV - 2 mg - Plasma - agg. (n=4)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                "Name": "Lin 1988 - IV administration, Caucasian subjects - Alprazolam - IV - 0.5 mg - Plasma - agg. (n=14)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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                "Name": "Lin 1988 - Oral administration, Caucasian subjects - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=14)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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                "Name": "Schmith 1991 - Normal subjects 0.5 mg - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=12)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Schmith 1991 - Normal subjects 0.5 mg - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=12)|Time",
                "Y": "Schmith 1991 - Normal subjects 0.5 mg - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                "Name": "Yasui 1996 - Treatment with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=12)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Yasui 1996 - Treatment with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=12)|Time",
                "Y": "Yasui 1996 - Treatment with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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              {
                "Name": "Yasui 1998 - Alprazolam with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=10)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Yasui 1998 - Alprazolam with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=10)|Time",
                "Y": "Yasui 1998 - Alprazolam with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                "Name": "Eller 1990 - Treatment C (fasting IR) - Alprazolam - PO - 1 mg - Plasma - agg. (n=21)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Eller 1990 - Treatment C (fasting IR) - Alprazolam - PO - 1 mg - Plasma - agg. (n=21)|Time",
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              {
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                "X": "Greenblatt 2000 - Control - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)|Time",
                "Y": "Greenblatt 2000 - Control - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                "X": "Juhl 1984 - Healthy control group - Alprazolam - PO - 1 mg - Plasma - agg. (n=17)|Time",
                "Y": "Juhl 1984 - Healthy control group - Alprazolam - PO - 1 mg - Plasma - agg. (n=17)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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              },
              {
                "Name": "Kaplan 1998 - Young - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Kaplan 1998 - Young - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)|Time",
                "Y": "Kaplan 1998 - Young - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
                "CurveOptions": {
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              },
              {
                "Name": "Kirkwood 1991 - Men - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Kirkwood 1991 - Men - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)|Time",
                "Y": "Kirkwood 1991 - Men - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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              {
                "Name": "Schmider 1999 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=9)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Schmider 1999 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=9)|Time",
                "Y": "Schmider 1999 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                  "Color": "#C0C000",
                  "LegendIndex": 26,
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              },
              {
                "Name": "Smith 1984 - Oral administration - Alprazolam - PO - 1 mg - Plasma - agg. (n=6)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Smith 1984 - Oral administration - Alprazolam - PO - 1 mg - Plasma - agg. (n=6)|Time",
                "Y": "Smith 1984 - Oral administration - Alprazolam - PO - 1 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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              {
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              {
                "Name": "Eberts 1980 - 14C-Alprazolam - Alprazolam - PO - 2 mg - Urine - agg. (n=6)-Alprazolam-Kidney-Urine-ArithmeticMean",
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                "Y": "Eberts 1980 - 14C-Alprazolam - Alprazolam - PO - 2 mg - Urine - agg. (n=6)|ObservedData|Kidney|Urine|Alprazolam|ArithmeticMean",
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              {
                "Name": "Schmith 1991 - Normal subjects 2 mg - Alprazolam - PO - 2 mg - Plasma - agg. (n=12)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Schmith 1991 - Normal subjects 2 mg - Alprazolam - PO - 2 mg - Plasma - agg. (n=12)|Time",
                "Y": "Schmith 1991 - Normal subjects 2 mg - Alprazolam - PO - 2 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                  "LineStyle": "None",
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              },
              {
                "Name": "Smith 1984 - IV administration - Alprazolam - IV - 1 mg - Plasma - agg. (n=6)-Alprazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Smith 1984 - IV administration - Alprazolam - IV - 1 mg - Plasma - agg. (n=6)|Time",
                "Y": "Smith 1984 - IV administration - Alprazolam - IV - 1 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Alprazolam|ArithmeticMean",
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                  "Color": "#00C000",
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                  "LineStyle": "None",
                  "Symbol": "Circle"
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              },
              {
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    {
      "Name": "IV",
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        {
          "Name": "0.25 mg",
          "Classifiables": [
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            "Adams 1984 - 0.25 mg, Individual 2 - Alprazolam - IV - 0.25 mg - Plasma - indiv."
          ]
        },
        {
          "Name": "4 mg",
          "Classifiables": [
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          ]
        },
        {
          "Name": "2 mg",
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          ]
        },
        {
          "Name": "1 mg",
          "Classifiables": [
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            "Smith 1984 - IV administration - Alprazolam - IV - 1 mg - Plasma - agg. (n=6)",
            "Venkatakrishnan 2005 - Alprazolam - Alprazolam - IV - 1 mg - Plasma - agg. (n=9)"
          ]
        },
        {
          "Name": "0.5 mg",
          "Classifiables": [
            "Kroboth 1988 - 0.5 mg/2 min - Alprazolam - IV - 0.5 mg - Plasma - agg. (n=4)",
            "Lin 1988 - IV administration, Caucasian subjects - Alprazolam - IV - 0.5 mg - Plasma - agg. (n=14)"
          ]
        },
        {
          "Name": "1.576 mg",
          "Classifiables": [
            "Kroboth 1988 - 1.0 mg/2 min, then 72 µg/hr for 8 hours - Alprazolam - IV - 1.576 mg - Plasma - agg. (n=4)"
          ]
        }
      ]
    },
    {
      "Name": "PO",
      "Classifications": [
        {
          "Name": "2 mg",
          "Classifiables": [
            "Schmith 1991 - Normal subjects 2 mg - Alprazolam - PO - 2 mg - Plasma - agg. (n=12)",
            "Eberts 1980 - 14C-Alprazolam - Alprazolam - PO - 2 mg - Urine - agg. (n=6)"
          ]
        },
        {
          "Name": "1 mg",
          "Classifiables": [
            "Eller 1990 - Treatment C (fasting IR) - Alprazolam - PO - 1 mg - Plasma - agg. (n=21)",
            "Friedman 1991 - Alprazolam group - Alprazolam - PO - 1 mg - Plasma - agg. (n=22)",
            "Greenblatt 1988 - Alprazolam group - Alprazolam - PO - 1 mg - Plasma - agg. (n=12)",
            "Greenblatt 1992 - Alprazolam group, Placebo first, Fluoxetine second - Alprazolam - PO - 1 mg - Plasma - agg. (n=11)",
            "Greenblatt 1998b - Alprazolam alone (Trial A) - Alprazolam - PO - 1 mg - Plasma - agg. (n=7)",
            "Greenblatt 2000 - Control - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)",
            "Juhl 1984 - Healthy control group - Alprazolam - PO - 1 mg - Plasma - agg. (n=17)",
            "Kaplan 1998 - Young - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)",
            "Kirkwood 1991 - Men - Alprazolam - PO - 1 mg - Plasma - agg. (n=8)",
            "Schmider 1999 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=9)",
            "Smith 1984 - Oral administration - Alprazolam - PO - 1 mg - Plasma - agg. (n=6)",
            "Wennerholm 2005 - Figure 1 - Alprazolam - PO - 1 mg - Plasma - agg. (n=12)"
          ]
        },
        {
          "Name": "0.5 mg",
          "Classifiables": [
            "Lin 1988 - Oral administration, Caucasian subjects - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=14)",
            "Schmith 1991 - Normal subjects 0.5 mg - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=12)"
          ]
        },
        {
          "Name": "0.8 mg",
          "Classifiables": [
            "Yasui 1996 - Treatment with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=12)",
            "Yasui 1998 - Alprazolam with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=10)",
            "Yasui 2000 - Alprazolam with water - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=8)"
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      "Classifiables": [
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        "Adams1984_IV_4mg",
        "Fleishaker1989_IV_1mg",
        "Lin1988_IV_0.5mg",
        "Smith1984_IV_1mg",
        "Venkatakrishnan2005_IV_1mg",
        "Bertz1997_IV_2mg"
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    },
    {
      "Name": "Oral",
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        "PO_2mg",
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