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(n=6)-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Gérardin 1976 - single oral dose of 600 mg - Carbamazepine - PO - 600 mg - Plasma - agg. (n=6)|Time", "Y": "Gérardin 1976 - single oral dose of 600 mg - Carbamazepine - PO - 600 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean", "CurveOptions": { "Color": "#7E0000FF", "LegendIndex": 27, "Symbol": "Circle" } }, { "Name": "Cotter 1977 - Single oral 800 mg dose - Carbamazepine - PO - 800 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Cotter 1977 - Single oral 800 mg dose - Carbamazepine - PO - 800 mg - Plasma - indiv.|Time", "Y": "Cotter 1977 - Single oral 800 mg dose - Carbamazepine - PO - 800 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#7D008000", "LegendIndex": 28, "Symbol": "Circle" } } ], "Name": "Carbamazepine_100,200,400,600mg_IR-tablet_fasted", "FontAndSize": { "Fonts": { "AxisSize": 10, "LegendSize": 8, "TitleSize": 16, "DescriptionSize": 12, "OriginSize": 8, "FontFamilyName": "Microsoft Sans Serif", "WatermarkSize": 32 } }, "Settings": { "SideMarginsEnabled": true, "LegendPosition": "None", "BackColor": "#FFFFFF", "DiagramBackColor": "#FFFFFF" } } }, { "Name": "Carbamazepine_IV+PO-solution", "Simulations": [ "Gerardin1990_Subject1_10mg-iv_100mg-po-sol" ], "IndividualComparison": { "Axes": [ { "Unit": "h", "Dimension": "Time", "Type": "X", "GridLines": false, "Visible": true, "DefaultColor": "#FFFFFF", "DefaultLineStyle": "None", "Scaling": "Linear", "NumberMode": "Normal" }, { "Unit": "mg/l", "Dimension": "Concentration (molar)", "Type": "Y", "GridLines": false, "Visible": true, "DefaultColor": "#FFFFFF", "DefaultLineStyle": "Solid", "Scaling": "Log", "NumberMode": "Normal" } ], "Curves": [ { "Name": "Gérardin 1990 - Subject 1, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Gérardin 1990 - Subject 1, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.|Time", "Y": "Gérardin 1990 - Subject 1, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#7DFF0000", "LegendIndex": 1, "Symbol": "Circle" } }, { "Name": "Gérardin 1990 - Subject 2, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Gérardin 1990 - Subject 2, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.|Time", "Y": "Gérardin 1990 - Subject 2, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#7DFF0000", "LegendIndex": 2, "Symbol": "Circle" } }, { "Name": "Gérardin 1990 - Subject 1, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Gérardin 1990 - Subject 1, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv.|Time", "Y": "Gérardin 1990 - Subject 1, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#650000FF", "LegendIndex": 3, "Symbol": "Circle" } }, { "Name": "Gérardin 1990 - Subject 2, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Gérardin 1990 - Subject 2, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv.|Time", "Y": "Gérardin 1990 - Subject 2, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#650000FF", "LegendIndex": 4, "Symbol": "Circle" } }, { "Name": "Rawlins 1975 - Volunteer G, 100 mg solution - Carbamazepine - PO - 100 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Rawlins 1975 - Volunteer G, 100 mg solution - Carbamazepine - PO - 100 mg - Plasma - indiv.|Time", "Y": "Rawlins 1975 - Volunteer G, 100 mg solution - Carbamazepine - PO - 100 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#650000FF", "LegendIndex": 5, "Symbol": "Circle" } }, { "Name": "Rawlins 1975 - Volunteer G, 50 mg solution - Carbamazepine - PO - 50 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Rawlins 1975 - Volunteer G, 50 mg solution - Carbamazepine - PO - 50 mg - Plasma - indiv.|Time", "Y": "Rawlins 1975 - Volunteer G, 50 mg solution - Carbamazepine - PO - 50 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#99C0C000", "LegendIndex": 6, "Symbol": "Circle" } }, { "Name": "Sumi 1987 - Solution, CBZ - Carbamazepine - PO - 200 mg - Serum - agg. 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(n=9)-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Wada 1978 - Syrup - Carbamazepine - PO - 200 mg - Serum - agg. (n=9)|Time", "Y": "Wada 1978 - Syrup - Carbamazepine - PO - 200 mg - Serum - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean", "CurveOptions": { "Color": "#65008000", "LegendIndex": 9, "Symbol": "Circle" } }, { "Name": "Levy 1975 - propylene glycol solution - Carbamazepine - PO - 6 mg/kg - Serum - agg. (n=6)-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Levy 1975 - propylene glycol solution - Carbamazepine - PO - 6 mg/kg - Serum - agg. (n=6)|Time", "Y": "Levy 1975 - propylene glycol solution - Carbamazepine - PO - 6 mg/kg - Serum - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean", "CurveOptions": { "Color": "#4AFF00FF", "LegendIndex": 10, "Symbol": "Circle" } }, { "Name": "Rawlins 1975 - Volunteer G, 200 mg solution - Carbamazepine - PO - 200 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-Individual", "X": "Rawlins 1975 - Volunteer G, 200 mg solution - Carbamazepine - PO - 200 mg - Plasma - indiv.|Time", "Y": "Rawlins 1975 - Volunteer G, 200 mg solution - Carbamazepine - PO - 200 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual", "CurveOptions": { "Color": "#65008000", "LegendIndex": 11, "Symbol": "Circle" } } ], "Name": "Carbamazepine_IV+PO-solution", "FontAndSize": { "Fonts": { "AxisSize": 10, "LegendSize": 8, "TitleSize": 16, "DescriptionSize": 12, "OriginSize": 8, "FontFamilyName": "Microsoft Sans Serif", "WatermarkSize": 32 } }, "Settings": { "SideMarginsEnabled": true, "LegendPosition": "None", "BackColor": "#FFFFFF", "DiagramBackColor": "#FFFFFF" } } } ], "ObservedDataClassifications": [ { "Name": "Pynnönen 1977", "Classifiables": [ "Pynnönen 1977 - Single 400 mg oral dose - Carbamazepine - PO - 400 mg - Plasma - agg. (n=6)", "Pynnönen 1977 - Single 400 mg oral dose - Carbamazepine - PO - 400 mg - Saliva - agg. (n=6)" ] }, { "Name": "Rawlins 1975", "Classifiables": [ "Rawlins 1975 - Volunteer G, 200 mg solution - Carbamazepine - PO - 200 mg - Plasma - indiv.", "Rawlins 1975 - Volunteer G, 200 mg tablet - Carbamazepine - PO - 200 mg - Plasma - indiv.", "Rawlins 1975 - Volunteer G, 100 mg solution - Carbamazepine - PO - 100 mg - Plasma - indiv.", "Rawlins 1975 - Volunteer G, 50 mg solution - Carbamazepine - PO - 50 mg - Plasma - indiv." ] }, { "Name": "Saint-Salvi 1987", "Classifiables": [ "Saint-Salvi 1987 - Carbamazepine alone - Carbamazepine - PO - 200 mg - Plasma - agg. (n=12)" ] }, { "Name": "Stevens 1998", "Classifiables": [ "Stevens 1998 - Tegretol-XR - Carbamazepine - PO - 400 mg - Plasma - agg. (n=15)", "Stevens 1998 - Carbatrol - Carbamazepine - PO - 400 mg - Plasma - agg. (n=15)" ] }, { "Name": "Strandjord 1975", "Classifiables": [ "Strandjord 1975 - Subject no. 2 - Carbamazepine - PO - 4.8 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 5 - Carbamazepine - PO - 5.9 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 6 - Carbamazepine - PO - 6 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 7 - Carbamazepine - PO - 6.9 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 8 - Carbamazepine - PO - 7.1 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 3 - Carbamazepine - PO - 5.1 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 4 - Carbamazepine - PO - 5.7 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 1 - Carbamazepine - PO - 4.6 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 12 - Carbamazepine - PO - 7.7 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 11 - Carbamazepine - PO - 7.5 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 10 - Carbamazepine - PO - 7.3 mg/kg - Serum - indiv.", "Strandjord 1975 - Subject no. 9 - Carbamazepine - PO - 7.3 mg/kg - Serum - indiv.", "Strandjord 1975 - Mean concentrations - Carbamazepine - PO - 400 mg - Serum - agg. (n=12)" ] }, { "Name": "Sumi 1987", "Classifiables": [ "Sumi 1987 - Solution, CBZ - Carbamazepine - PO - 200 mg - Serum - agg. (n=6)", "Sumi 1987 - Tablet B, CBZ - Carbamazepine - PO - 200 mg - Serum - agg. (n=6)", "Sumi 1987 - Tablet A, CBZ - Carbamazepine - PO - 200 mg - Serum - agg. (n=6)", "Sumi 1987 - Tablet C, CBZ - Carbamazepine - PO - 200 mg - Serum - agg. (n=6)" ] }, { "Name": "Tomson 1983", "Classifiables": [ "Tomson 1983 - Subject GB, 200 mg CBZ - Carbamazepine - PO - 200 mg - Plasma - indiv." ] }, { "Name": "US Patent Application - US 2009 0169619 A1", "Classifiables": [ "US Patent Application - US 2009 0169619 A1 - Reference - Carbamazepine - PO - 300 mg - Plasma - agg. (n=12)", "US Patent Application - US 2009 0169619 A1 - Test - Carbamazepine - PO - 300 mg - Plasma - agg. (n=12)" ] }, { "Name": "Wada 1978", "Classifiables": [ "Wada 1978 - Syrup - Carbamazepine - PO - 200 mg - Serum - agg. (n=9)", "Wada 1978 - Tablet - Carbamazepine - PO - 200 mg - Saliva - agg. (n=9)", "Wada 1978 - Syrup - Carbamazepine - PO - 200 mg - Saliva - agg. (n=9)", "Wada 1978 - Tablet - Carbamazepine - PO - 200 mg - Serum - agg. (n=9)" ] }, { "Name": "Wong 1983", "Classifiables": [ "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv." ] }, { "Name": "Morselli 1975", "Classifiables": [ "Morselli 1975 - Subject P.M.G. - Carbamazepine - PO - 400 mg - Urine - indiv.", "Morselli 1975 - Subject P.B. - Carbamazepine - PO - 400 mg - Urine - indiv.", "Morselli 1975 - Subject F.G. - Carbamazepine - PO - 400 mg - Urine - indiv.", "Morselli 1975 - Healthy volunteers - Carbamazepine - PO - 400 mg - Plasma - agg. (n=5)" ] }, { "Name": "Møller 2001", "Classifiables": [ "Møller 2001 - CBZ alone - Carbamazepine - PO - 100, 200, 400 mg - Plasma - agg. (n=12)" ] }, { "Name": "Miles 1989", "Classifiables": [ "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)" ] }, { "Name": "Meyer 1998", "Classifiables": [ "Meyer 1998 - Product 1 (Tegretol) - Carbamazepine - PO - 200 mg - Plasma - agg. (n=18)" ] }, { "Name": "Meyer 1992", "Classifiables": [ "Meyer 1992 - Product 1 (Tegretol) - Carbamazepine - PO - 200 mg - Plasma - agg. (n=24)" ] }, { "Name": "McLean 2001", "Classifiables": [ "McLean 2001 - CBZ, intact capsule, fasting state - Carbamazepine - PO - 400 mg - Plasma - agg. (n=12)" ] }, { "Name": "Levy 1975", "Classifiables": [ "Levy 1975 - propylene glycol solution - Carbamazepine - PO - 6 mg/kg - Serum - agg. (n=6)", "Levy 1975 - commercial tablet - Carbamazepine - PO - 6 mg/kg - Serum - agg. (n=6)" ] }, { "Name": "Kovacević 2009", "Classifiables": [ "Kovacević 2009 - CBZ CR tablet (test) - Carbamazepine - PO - 400 mg - Plasma - agg. (n=24)", "Kovacević 2009 - CBZ IR tablet (test) - Carbamazepine - PO - 400 mg - Plasma - agg. (n=18)", "Kovacević 2009 - CBZ CR tablet (reference) - Carbamazepine - PO - 400 mg - Plasma - agg. (n=24)", "Kovacević 2009 - CBZ IR tablet (reference) - Carbamazepine - PO - 400 mg - Plasma - agg. (n=18)" ] }, { "Name": "Kim 2005", "Classifiables": [ "Kim 2005 - Placebo (without probenecid) - Carbamazepine - PO - 200 mg - Plasma - agg. (n=10)" ] }, { "Name": "Kayali 1994", "Classifiables": [ "Kayali 1994 - Tegretol - Carbamazepine - PO - 200 mg - Plasma - agg. (n=5)" ] }, { "Name": "Ji 2008", "Classifiables": [ "Ji 2008 - Carbamazepine, control (Arm 2) - Carbamazepine - PO - 200 / 400 mg - Plasma - agg. (n=36)" ] }, { "Name": "Gérardin 1990", "Classifiables": [ "Gérardin 1990 - Subject 1, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.", "Gérardin 1990 - Subject 1, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv.", "Gérardin 1990 - Subject 2, 2 h IV infusion - Carbamazepine - IV - 10 mg - Plasma - indiv.", "Gérardin 1990 - Subject 2, 100 mg 15N-CBZ as 2% oral suspension - Carbamazepine - PO - 100 mg - Plasma - indiv." ] }, { "Name": "Gérardin 1976", "Classifiables": [ "Gérardin 1976 - Repeated dose 200 mg, Geomean - Carbamazepine - PO - 200 mg - Plasma - agg. (n=5)", "Gérardin 1976 - Repeated dose 200 mg, Subject 1 - Carbamazepine - PO - 200 mg - Plasma - indiv.", "Gérardin 1976 - Repeated dose 200 mg, Subject 3 - Carbamazepine - PO - 200 mg - Plasma - indiv.", "Gérardin 1976 - Repeated dose 200 mg, Subject 4 - Carbamazepine - PO - 200 mg - Plasma - indiv.", "Gérardin 1976 - Repeated dose 200 mg, Subject 5 - Carbamazepine - PO - 200 mg - Plasma - indiv.", "Gérardin 1976 - single oral dose of 100 mg - Carbamazepine - PO - 100 mg - Plasma - agg. (n=6)", "Gérardin 1976 - single oral dose of 600 mg - Carbamazepine - PO - 600 mg - Plasma - agg. (n=6)", "Gérardin 1976 - single oral dose of 200 mg - Carbamazepine - PO - 200 mg - Plasma - agg. (n=6)", "Gérardin 1976 - Repeated dose 200 mg, Subject 2 - Carbamazepine - PO - 200 mg - Plasma - indiv." ] }, { "Name": "European Patent Application 2000", "Classifiables": [ "European Patent Application 2000 - Tegretol CR 400 mg tablet, lot A - Carbamazepine - PO - 400 mg - Plasma - agg. (n=34)", "European Patent Application 2000 - Tegretol CR 400 mg tablet, lot B - Carbamazepine - PO - 400 mg - Plasma - agg. (n=34)", "European Patent Application 2000 - Tegretol CR 600 mg tablet - Carbamazepine - PO - 600 mg - Plasma - agg. (n=19)" ] }, { "Name": "Elqidra 2009", "Classifiables": [ "Elqidra 2009 - Tegretol - Carbamazepine - PO - 200 mg - Plasma - agg. (n=6)" ] }, { "Name": "Dalton 1985b", "Classifiables": [ "Dalton 1985b - Placebo (without ranitidine) - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)" ] }, { "Name": "Dalton 1985a", "Classifiables": [ "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)" ] }, { "Name": "Cotter 1977", "Classifiables": [ "Cotter 1977 - Single oral 800 mg dose - Carbamazepine - PO - 800 mg - Plasma - indiv." ] }, { "Name": "Cawello 2010", "Classifiables": [ "Cawello 2010 - CBZ alone (without lacosamide) - Carbamazepine - PO - 100, 200 mg - Plasma - agg. (n=10)" ] }, { "Name": "Caraco 1995", "Classifiables": [ "Caraco 1995 - Lean subjects - Carbamazepine - PO - 200 mg - Plasma - agg. (n=13)" ] }, { "Name": "Burstein 2000", "Classifiables": [ "Burstein 2000 - Before St John’s Wort - Carbamazepine - PO - 100, 200, 400 mg - Plasma - agg. (n=8)" ] }, { "Name": "Bianchetti 1987", "Classifiables": [ "Bianchetti 1987 - CBZ before progabide administration - Carbamazepine - PO - 400 mg - Plasma - agg. (n=6)" ] }, { "Name": "Bernus 1994", "Classifiables": [ "Bernus 1994 - CBZ, second dose - Carbamazepine - PO - 600 mg - Urine - agg. (n=6)", "Bernus 1994 - CBZ, first dose - Carbamazepine - PO - 600 mg - Urine - agg. (n=6)", "Bernus 1994 - CBZ conc - Carbamazepine - PO - 600 mg - Plasma - agg. (n=6)" ] }, { "Name": "Bedada 2016", "Classifiables": [ "Bedada 2016 - Control phase - Carbamazepine - PO - 200 mg - Plasma - agg. (n=12)" ] }, { "Name": "Bedada 2015", "Classifiables": [ "Bedada 2015 - Control phase - Carbamazepine - PO - 200 mg - Plasma - agg. (n=12)" ] }, { "Name": "Barzaghi 1987", "Classifiables": [ "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)" ] }, { "Name": "Eichelbaum 1985", "Classifiables": [ "Eichelbaum 1985 - Healthy subject EH - Carbamazepine - PO - 200 mg - Plasma - indiv." ] } ] }