{ "Version": 79, "ExpressionProfiles": [ { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Grahnen_1979", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Grahnen_1979", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Grahnen_1979", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Tiseo_1998", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Tiseo_1998", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Tiseo_1998", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Barbhaiya_1995", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Barbhaiya_1995", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Barbhaiya_1995", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Bodemar_1979", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Bodemar_1979", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Bodemar_1979", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Bodemar_1981", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Bodemar_1981", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Bodemar_1981", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Burland_1975", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Burland_1975", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Burland_1975", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "D'Angio_1986", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "D'Angio_1986", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "D'Angio_1986", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Kanto_1981", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Kanto_1981", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Kanto_1981", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Larsson_1982", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Larsson_1982", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Larsson_1982", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Lebert_1981", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Lebert_1981", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Lebert_1981", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Mihaly_1984", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Mihaly_1984", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Mihaly_1984", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Morgan_1983", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Morgan_1983", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Morgan_1983", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Somogyi_1981", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Somogyi_1981", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Somogyi_1981", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Walkenstein_1978", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Walkenstein_1978", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Walkenstein_1978", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Enzyme", "Species": "Human", "Molecule": "AADAC", "Category": "Elliott_1984", "Parameters": [ { "Path": "AADAC|Reference concentration", "Value": 1.0, "Unit": "µmol/l" }, { "Path": "AADAC|Relative expression in blood cells", "Value": 3.9102564103E-05 }, { "Path": "AADAC|Relative expression in plasma", "Value": 3.9102564103E-05 }, { "Path": "AADAC|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "AADAC|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|AADAC|Relative expression", "Value": 4.8717948718E-05 }, { "Path": "Organism|Brain|Intracellular|AADAC|Relative expression", "Value": 3.9743589744E-05 }, { "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression", "Value": 0.0011923076923 }, { "Path": "Organism|Heart|Intracellular|AADAC|Relative expression", "Value": 0.0026602564103 }, { "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression", "Value": 5.7051282051E-05 }, { "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|AADAC|Relative expression", "Value": 0.0269230769 }, { "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression", "Value": 0.00020833333333 }, { "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression", "Value": 0.1474358974 }, { "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression", "Value": 0.00037115384615 }, { "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression", "Value": 0.0775641026 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" }, { "Type": "OtherProtein", "Species": "Human", "Molecule": "ATP1A2", "Category": "Elliott_1984", "Parameters": [ { "Path": "ATP1A2|Reference concentration", "Value": 0.39140774, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "ATP1A2|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "ATP1A2|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", "Value": 0.0062154033171 }, { "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", "Value": 1.0 }, { "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", "Value": 0.0508741242 }, { "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", "Value": 0.3179118843 }, { "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", "Value": 0.0158938619 }, { "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", "Value": 0.0223784807 }, { "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", "Value": 0.0223784807 }, { "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", "Value": 0.0272345453 }, { "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", "Value": 0.7034193524 }, { "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", "Value": 0.0073903254795 }, { "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", "Value": 0.0389467988 }, { "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", "Value": 0.0103243118 }, { "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", "Value": 0.0309435884 } ], "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" }, { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP2C8", "Category": "Elliott_1984", "Parameters": [ { "Path": "CYP2C8|Reference concentration", "Value": 2.56, "Unit": "µmol/l" }, { "Path": "CYP2C8|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "CYP2C8|t1/2 (liver)", "Value": 23.000001425, "Unit": "h" }, { "Path": "Organism|Gonads|Intracellular|CYP2C8|Relative expression", "Value": 0.0138116248 }, { "Path": "Organism|Liver|Pericentral|Intracellular|CYP2C8|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|CYP2C8|Relative expression", "Value": 1.0 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome", "Ontogeny": { "Name": "CYP2C8" } }, { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP3A4", "Category": "Elliott_1984", "Parameters": [ { "Path": "CYP3A4|Reference concentration", "Value": 4.32, "Unit": "µmol/l" }, { "Path": "CYP3A4|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "CYP3A4|t1/2 (liver)", "Value": 36.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome", "Ontogeny": { "Name": "CYP3A4" } }, { "Type": "OtherProtein", "Species": "Human", "Molecule": "GABRG2", "Category": "Elliott_1984", "Parameters": [ { "Path": "GABRG2|Reference concentration", "Value": 1.04099689, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "GABRG2|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "GABRG2|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|GABRG2|Relative expression", "Value": 1.0 } ], "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" }, { "Type": "Transporter", "Species": "Human", "Molecule": "MATE1", "Category": "Elliott_1984", "Parameters": [ { "Path": "MATE1|Reference concentration", "Value": 0.13257, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "MATE1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "MATE1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|MATE1|Relative expression", "Value": 0.4295320813 }, { "Path": "Organism|Kidney|Intracellular|MATE1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Muscle|Intracellular|MATE1|Relative expression", "Value": 0.3637328555 } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OAT3", "Category": "Elliott_1984", "Parameters": [ { "Path": "OAT3|Reference concentration", "Value": 0.0917, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OAT3|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OAT3|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OAT3|Relative expression", "Value": 0.00061613691932 }, { "Path": "Organism|Kidney|Intracellular|OAT3|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 }, { "Path": "Organism|Liver|Periportal|Intracellular|OAT3|Relative expression", "Value": 0.00016503667482 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OATP1B1", "Category": "Elliott_1984", "Parameters": [ { "Path": "OATP1B1|Reference concentration", "Value": 1.0, "Unit": "µmol/l" }, { "Path": "OATP1B1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OATP1B1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", "Value": 0.00014166666667 }, { "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", "Value": 0.0141666667 }, { "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", "Value": 0.0008253968254 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", "Value": 4.0079365079E-05 }, { "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", "Value": 0.00064682539683 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "OCT1", "Category": "Elliott_1984", "Parameters": [ { "Path": "OCT1|Reference concentration", "Value": 0.16465, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "OCT1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OCT1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|OCT1|Relative expression", "Value": 0.02439093 }, { "Path": "Organism|Brain|Intracellular|OCT1|Relative expression", "Value": 0.0135293069 }, { "Path": "Organism|Gonads|Intracellular|OCT1|Relative expression", "Value": 0.0035130263768 }, { "Path": "Organism|Heart|Intracellular|OCT1|Relative expression", "Value": 0.0067231912312 }, { "Path": "Organism|Kidney|Intracellular|OCT1|Relative expression", "Value": 0.031737522 }, { "Path": "Organism|LargeIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT1|Relative expression", "Value": 0.0315629708 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OCT1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OCT1|Relative expression", "Value": 0.0146483426 }, { "Path": "Organism|Muscle|Intracellular|OCT1|Relative expression", "Value": 0.0407525944 }, { "Path": "Organism|Pancreas|Intracellular|OCT1|Relative expression", "Value": 0.0065687827703 }, { "Path": "Organism|Skin|Intracellular|OCT1|Relative expression", "Value": 0.0119814482 }, { "Path": "Organism|SmallIntestine|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OCT1|Relative expression", "Value": 0.0245459351 }, { "Path": "Organism|Spleen|Intracellular|OCT1|Relative expression", "Value": 0.0050234148247 }, { "Path": "Organism|Stomach|Intracellular|OCT1|Relative expression", "Value": 0.0093257582694 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Transporter", "Species": "Human", "Molecule": "P-gp", "Category": "Elliott_1984", "Parameters": [ { "Path": "Organism|Bone|Intracellular|P-gp|Relative expression", "Value": 0.0242518189 }, { "Path": "Organism|Brain|Intracellular|P-gp|Relative expression", "Value": 0.07608904 }, { "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression", "Value": 0.017417973 }, { "Path": "Organism|Heart|Intracellular|P-gp|Relative expression", "Value": 0.0419198106 }, { "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression", "Value": 0.7092198582 }, { "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression", "Value": 0.1108416465 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression", "Value": 0.1916810428 }, { "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression", "Value": 0.1916810428 }, { "Path": "Organism|Lung|Intracellular|P-gp|Relative expression", "Value": 0.0657549316 }, { "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression", "Value": 0.0128342959 }, { "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression", "Value": 0.0142510689 }, { "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression", "Value": 0.2808543974 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression", "Value": 0.0742555691 }, { "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression", "Value": 0.0260852897 }, { "Path": "P-gp|Reference concentration", "Value": 1.41, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "P-gp|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "P-gp|t1/2 (liver)", "Value": 36.0, "Unit": "h" } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" 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(n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Path": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - IV 200 mg, beginning of treatment - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Lebert 1981 - IV 300 mg - Cimetidine - IV - 300 mg - Plasma - agg. (n=8)" }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 1 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 2 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 3 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 4 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 5 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 6 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 7 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv." }, { "Scaling": "Linear", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)" }, { "Scaling": "Log", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)" } ], "IdentificationParameters": [ { "Name": "kcat OCT1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|OCT1-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|OCT1-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|OCT1-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|OCT1-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|OCT1-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|OCT1-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|OCT1-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|OCT1-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 10911.84, "Unit": "1/min" }, { "Name": "MinValue", "Value": 327.0, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 327757.510871441, "Unit": "1/min" } ] }, { "Name": "kcat OAT3", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|OAT3-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|OAT3-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|OAT3-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|OAT3-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|OAT3-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|OAT3-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 3268741.98, "Unit": "1/min" }, { "Name": "MinValue", "Value": 1111.0, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 110821186.8, "Unit": "1/min" } ] }, { "Name": "kcat MATE1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|MATE1-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|MATE1-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 103.56, "Unit": "1/min" }, { "Name": "MinValue", "Value": 5.759, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 575.9049486992, "Unit": "1/min" } ] }, { "Name": "Specific intestinal permeability (transcellular)", "Scaling": "Log", "LinkedParameters": [ "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Bodemar 1981, n=10|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Burland 1975, caps|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Burland 1975, sol|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Kanto 1981, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Mihaly 1984, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg, Bodemar 1981, n=9|Cimetidine|Specific intestinal permeability (transcellular)", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|Specific intestinal permeability (transcellular)", "po 800 mg, Bodemar 1981, n=9|Cimetidine|Specific intestinal permeability (transcellular)" ], "Parameters": [ { "Name": "Start value", "Value": 2.87E-06, "Unit": "cm/min" }, { "Name": "MinValue", "Value": 2.87E-07, "Unit": "cm/min" }, { "Name": "MaxValue", "Value": 2.8740150156E-05, "Unit": "cm/min" } ] }, { "Name": "Specific clearance", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Bodemar 1981, n=10|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Larsson 1982, n=9|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Mihaly 1984, n=6|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Bodemar 1981, n=10|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Burland 1975, caps|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Burland 1975, sol|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Kanto 1981, n=8|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Mihaly 1984, n=8|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg, Bodemar 1981, n=9|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 800 mg, Bodemar 1981, n=9|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance" ], "Parameters": [ { "Name": "Start value", "Value": 0.1600808777, "Unit": "1/min" }, { "Name": "MinValue", "Value": 0.0016, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 1.600808777, "Unit": "1/min" } ] } ] }, { "Name": "Parameter Identification 2", "Simulations": [ "iv 100 mg (5 min), Grahnen 1979, n=3", "iv 200 mg (30 min),Morgan 1983, n=4", "iv 200 mg (5 min),Morgan 1983, n=6", "iv 200 mg, Bodemar 1981, n=10", "iv 200 mg, Larsson 1982, n=9", "iv 200 mg, Mihaly 1984, n=6", "iv 300 mg (2 min), Lebert 1981, n=1", "iv 300 mg (2 min), Walkenstein 1978, n=12", "po 200 mg (tab), Bodemar 1979 (fasted)", "po 200 mg (tab), Bodemar 1979 (fed)", "po 200 mg, Bodemar 1981, n=10", "po 200 mg, Burland 1975, caps", "po 200 mg, Burland 1975, sol", "po 200 mg, Kanto 1981, n=8", "po 200 mg, Mihaly 1984, n=8", "po 200/400 mg QID, Bodemar 1981 (fasted)", "po 300 mg (sol), Walkenstein 1978, n=24", "po 300 mg (tab), D'Angio 1986, n=6", "po 300 mg (tabl), Walkenstein 1978, n=12", "po 300 mg QID (sol), Barbhaiya 1995, n=18", "po 400 mg (tab), Bodemar 1979, n=10", "po 400 mg (tab), Somogyi 1981, n=8", "po 400 mg (tab),Grahnen 1979, n=3", "po 400 mg, Bodemar 1981, n=9", "po 800 mg (tab) qd, Tiseo 1998, n=18", "po 800 mg, Bodemar 1981, n=9" ], "Configuration": { "LLOQMode": "OnlyObservedData", "RemoveLLOQMode": "NoTrailing", "CalculateJacobian": false, "Algorithm": { "Name": "Levenberg - Marquardt (MPFit)", "Properties": [ { "Name": "ftol", "Value": 0.001, "Type": "Double" }, { "Name": "xtol", "Value": 1E-06, "Type": "Double" }, { "Name": "gtol", "Value": 1E-10, "Type": "Double" }, { "Name": "stepfactor", "Value": 100.0, "Type": "Double" }, { "Name": "maxiter", "Value": 200.0, "Type": "Double" }, { "Name": "maxfev", "Value": 0.0, "Type": "Double" }, { "Name": "epsfcn", "Value": 1E-09, "Type": "Double" } ] } }, "OutputMappings": [ { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LH - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual KN - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LOE - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - IV 100 mg, urine mean % of dose - Cimetidine - IV - 100 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg (30 min),Morgan 1983, n=4|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 30 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=4)" }, { "Scaling": "Log", "Path": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 5 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - IV 200 mg - Cimetidine - IV - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - IV 200 mg, Urine - Cimetidine - IV - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - IV 200 mg, beginning of treatment - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Lebert 1981 - IV 300 mg - Cimetidine - IV - 300 mg - Plasma - agg. (n=8)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 1 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 2 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 3 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 4 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 5 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 6 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 7 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Weight": 2.0, "Path": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)" }, { "Scaling": "Log", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. 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IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 20, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 21, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 22, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 23, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 24, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 25, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 26, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 27, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 28, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 29, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 30, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 31, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 32, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 33, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 34, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 35, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 36, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 37, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 38, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#00C000", "LegendIndex": 39, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C00000", "LegendIndex": 40, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FFFF00", "LegendIndex": 41, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#008080", "LegendIndex": 42, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#800080", "LegendIndex": 43, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|Time", "Y": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 44, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|Time", "Y": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#80FF80", "LegendIndex": 45, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#808000", "LegendIndex": 46, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 47, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 48, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 49, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 50, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 51, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 52, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 53, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 54, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 55, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 56, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 57, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 58, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 59, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 60, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 61, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 62, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 63, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 64, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 65, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 66, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 67, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 68, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 69, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 70, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 71, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 72, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 73, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 74, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 75, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 76, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 77, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 78, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 79, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 80, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 81, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 82, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 83, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 84, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 85, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 86, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 87, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 88, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 89, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 90, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 91, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 92, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 93, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 94, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 95, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 96, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 97, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 98, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 99, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 100, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. 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(n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#808000", "LegendIndex": 46, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 47, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 48, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 49, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 50, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 51, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 52, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 53, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 54, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 55, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 56, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 57, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 58, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 59, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 60, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 61, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 62, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 63, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 64, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 65, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 66, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 67, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 68, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 69, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 70, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 71, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 72, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 73, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 74, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 75, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 76, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 77, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 78, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 79, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 80, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 81, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 82, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 83, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 84, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 85, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 86, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 87, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 88, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 89, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 90, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 91, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 92, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 93, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 94, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 95, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 96, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 97, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 98, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 99, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 100, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. 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(n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "Visible": false, "VisibleInLegend": false, "Color": "#00FF00", "LegendIndex": 102, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)|Time", "Y": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. 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"Color": "#00C0C0", "LegendIndex": 124, "LineStyle": "Dash" } }, { "Name": "po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C0C000", "LegendIndex": 125 } }, { "Name": "po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Color": "#00C000", "LegendIndex": 126, "LineStyle": "Dash" } }, { "Name": "iv 300 mg (2 min), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": 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Bodemar 1981, n=10", "iv 200 mg, Larsson 1982, n=9", "iv 200 mg, Mihaly 1984, n=6", "iv 300 mg (2 min), Lebert 1981, n=1", "iv 300 mg (2 min), Walkenstein 1978, n=12", "po 200 mg (tab), Bodemar 1979 (fasted)", "po 200 mg (tab), Bodemar 1979 (fed)", "po 200 mg, Bodemar 1981, n=10", "po 200 mg, Burland 1975, caps", "po 200 mg, Burland 1975, sol", "po 200 mg, Kanto 1981, n=8", "po 200 mg, Mihaly 1984, n=8", "po 200/400 mg QID, Bodemar 1981 (fasted)", "po 300 mg (sol), Walkenstein 1978, n=24", "po 300 mg (tab), D'Angio 1986, n=6", "po 300 mg (tabl), Walkenstein 1978, n=12", "po 300 mg QID (sol), Barbhaiya 1995, n=18", "po 400 mg (tab), Bodemar 1979, n=10", "po 400 mg (tab), Somogyi 1981, n=8", "po 400 mg (tab),Grahnen 1979, n=3", "po 400 mg, Bodemar 1981, n=9", "po 800 mg (tab) qd, Tiseo 1998, n=18", "po 800 mg, Bodemar 1981, n=9", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ], "Configuration": { "LLOQMode": "OnlyObservedData", "RemoveLLOQMode": "NoTrailing", "CalculateJacobian": false, "Algorithm": { "Name": "Levenberg - Marquardt (MPFit)", "Properties": [ { "Name": "ftol", "Value": 0.001, "Type": "Double" }, { "Name": "xtol", "Value": 1E-06, "Type": "Double" }, { "Name": "gtol", "Value": 1E-10, "Type": "Double" }, { "Name": "stepfactor", "Value": 100.0, "Type": "Double" }, { "Name": "maxiter", "Value": 200.0, "Type": "Double" }, { "Name": "maxfev", "Value": 0.0, "Type": "Double" }, { "Name": "epsfcn", "Value": 1E-09, "Type": "Double" } ] }, "RunMode": { "NumberOfRuns": 20 } }, "OutputMappings": [ { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LH - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual KN - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LOE - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - IV 100 mg, urine mean % of dose - Cimetidine - IV - 100 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg (30 min),Morgan 1983, n=4|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 30 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=4)" }, { "Scaling": "Log", "Path": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 5 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - IV 200 mg - Cimetidine - IV - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - IV 200 mg, Urine - Cimetidine - IV - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - IV 200 mg, beginning of treatment - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Lebert 1981 - IV 300 mg - Cimetidine - IV - 300 mg - Plasma - agg. (n=8)", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 1 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 2 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 3 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 4 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 5 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 6 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 7 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Weight": 2.0, "Path": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)" }, { "Scaling": "Log", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 2.0, "Path": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Weight": 20.0, "Path": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)" } ], "IdentificationParameters": [ { "Name": "kcat OCT1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 200 mg, 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"Name": "MaxValue", "Value": 327757.510871441, "Unit": "1/min" } ] }, { "Name": "kcat OAT3", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Kanto 1981, 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"MinValue", "Value": 1111.0, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 110821186.8, "Unit": "1/min" } ] }, { "Name": "kcat MATE1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|MATE1-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|MATE1-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|MATE1-Paper|kcat" ], "Parameters": [ { "Name": 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(n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 38, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#00C000", "LegendIndex": 39, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C00000", "LegendIndex": 40, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FFFF00", "LegendIndex": 41, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#008080", "LegendIndex": 42, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#800080", "LegendIndex": 43, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|Time", "Y": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 44, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|Time", "Y": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#80FF80", "LegendIndex": 45, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#808000", "LegendIndex": 46, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 47, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 48, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 49, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 50, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 51, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 52, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 53, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 54, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 55, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 56, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 57, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 58, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 59, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 60, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 61, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 62, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 63, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 64, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 65, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 66, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 67, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 68, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 69, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 70, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 71, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 72, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 73, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 74, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 75, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 76, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 77, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 78, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 79, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 80, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 81, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 82, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 83, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 84, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 85, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 86, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 87, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 88, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 89, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 90, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 91, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 92, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 93, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 94, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 95, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 96, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 97, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 98, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 99, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 100, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)|Time", "Y": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C04000", "LegendIndex": 101, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#00FF00", "LegendIndex": 102, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)|Time", "Y": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#808080", "LegendIndex": 103, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.|Time", "Y": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 104, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.|Time", "Y": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 105, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.|Time", "Y": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 106, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)|Time", "Y": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#00C000", "LegendIndex": 107, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)|Time", "Y": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C00000", "LegendIndex": 108, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)|Time", "Y": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FFFF00", "LegendIndex": 109, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)|Time", "Y": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#008080", "LegendIndex": 110, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)|Time", "Y": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#800080", "LegendIndex": 111, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)|Time", "Y": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 112, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)-Midazolam-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)|Time", "Y": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)|ObservedData|Peripheral Venous Blood|Plasma|Midazolam|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#80FF80", "LegendIndex": 113, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "1-po 200/400 mg QID, Bodemar 1981 (fasted)-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808000", "LegendIndex": 114 } }, { "Name": "1-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF0000", "LegendIndex": 115 } }, { "Name": "1-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#0000FF", "LegendIndex": 116, "LineStyle": "Dash" } }, { "Name": "1-po 300 mg QID (sol), Barbhaiya 1995, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C04000", "LegendIndex": 117 } }, { "Name": "1-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#ECD33A", "LegendIndex": 118 } }, { "Name": "1-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FF8080", "LegendIndex": 119, "LineStyle": "Dash" } }, { "Name": "1-po 400 mg (tab), Bodemar 1979, n=10-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 120 } }, { "Name": "1-iv 200 mg, Larsson 1982, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C000C0", "LegendIndex": 121 } }, { "Name": "1-iv 200 mg, Larsson 1982, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#C04000", "LegendIndex": 122, "LineStyle": "Dash" } }, { "Name": "1-po 200 mg, Burland 1975, caps-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 123 } }, { "Name": "1-iv 200 mg (5 min),Morgan 1983, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF00FF", "LegendIndex": 124 } }, { "Name": "1-Elliott 1984, Midazolam po + 200/400 mg cimetidine-Midazolam-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "Elliott 1984, Midazolam po + 200/400 mg 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"iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C000C0", "LegendIndex": 165 } }, { "Name": "2-iv 200 mg, Larsson 1982, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#C04000", "LegendIndex": 166, "LineStyle": "Dash" } }, { "Name": "2-po 300 mg QID (sol), Barbhaiya 1995, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C04000", "LegendIndex": 167 } }, { "Name": "2-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#ECD33A", "LegendIndex": 168 } }, { "Name": "2-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FF8080", "LegendIndex": 169, "LineStyle": "Dash" } }, { "Name": "2-iv 300 mg (2 min), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#8080FF", "LegendIndex": 170 } }, { "Name": "2-iv 300 mg (2 min), Walkenstein 1978, n=12-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#C0C000", "LegendIndex": 171, "LineStyle": "Dash" } }, { "Name": "2-iv 300 mg (2 min), Lebert 1981, n=1-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808080", "LegendIndex": 172 } }, { "Name": "2-po 300 mg (tab), D'Angio 1986, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 173 } }, { "Name": "2-po 200 mg (tab), Bodemar 1979 (fasted)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 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"LegendIndex": 333 } }, { "Name": "7-po 200/400 mg QID, Bodemar 1981 (fasted)-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808000", "LegendIndex": 334 } }, { "Name": "7-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF0000", "LegendIndex": 335 } }, { "Name": "7-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#0000FF", "LegendIndex": 336, 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n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#0000FF", "LegendIndex": 395, "LineStyle": "Dash" } }, { "Name": "8-po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C0C000", "LegendIndex": 396 } }, { "Name": "8-po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#00C000", "LegendIndex": 397, "LineStyle": "Dash" } }, { "Name": "8-po 300 mg (tab), D'Angio 1986, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg (tab), D'Angio 1986, 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n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF00FF", "LegendIndex": 517 } }, { "Name": "12-po 200/400 mg QID, Bodemar 1981 (fasted)-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808000", "LegendIndex": 518 } }, { "Name": "12-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF0000", "LegendIndex": 519 } }, { "Name": "12-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#0000FF", "LegendIndex": 520, "LineStyle": "Dash" } }, { "Name": "12-Elliott 1984, Midazolam po + 200/400 mg cimetidine-Midazolam-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 521 } }, { "Name": "12-po 200 mg, Kanto 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 522 } }, { "Name": "12-po 300 mg (tabl), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (tabl), 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"yAxisType": "Y2", "Visible": false, "Color": "#0000FF", "LegendIndex": 584, "LineStyle": "Dash" } }, { "Name": "14-iv 300 mg (2 min), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#8080FF", "LegendIndex": 585 } }, { "Name": "14-iv 300 mg (2 min), Walkenstein 1978, n=12-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#C0C000", "LegendIndex": 586, "LineStyle": "Dash" } }, { "Name": "14-iv 300 mg (2 min), Lebert 1981, n=1-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Lebert 1981, 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n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 652 } }, { "Name": "15-po 200 mg, Mihaly 1984, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 653 } }, { "Name": "16-iv 300 mg (2 min), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#8080FF", "LegendIndex": 654 } }, { "Name": "16-iv 300 mg (2 min), Walkenstein 1978, 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Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 670 } }, { "Name": "16-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#ECD33A", "LegendIndex": 671 } }, { "Name": "16-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FF8080", "LegendIndex": 672, "LineStyle": "Dash" } }, { "Name": "16-po 300 mg (tab), D'Angio 1986, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", 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n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 719 } }, { "Name": "17-po 400 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FFFF00", "LegendIndex": 720, "LineStyle": "Dash" } }, { "Name": "17-iv 200 mg, Mihaly 1984, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 721 } }, { "Name": "17-po 200 mg, Burland 1975, sol-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood 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"Color": "#00C000", "LegendIndex": 731 } }, { "Name": "18-po 200 mg, Burland 1975, sol-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 732 } }, { "Name": "18-po 200 mg, Burland 1975, caps-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 733 } }, { "Name": "18-iv 200 mg (5 min),Morgan 1983, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF00FF", "LegendIndex": 734 } }, { 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"Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LOE - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - IV 100 mg, urine mean % of dose - Cimetidine - IV - 100 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg (30 min),Morgan 1983, n=4|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 30 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=4)" }, { "Scaling": "Log", "Path": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 5 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - IV 200 mg - Cimetidine - IV - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - IV 200 mg, Urine - Cimetidine - IV - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - IV 200 mg, beginning of treatment - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Lebert 1981 - IV 300 mg - Cimetidine - IV - 300 mg - Plasma - agg. (n=8)", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 1 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 2 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 3 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 4 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 5 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 6 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 7 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)" }, { "Scaling": "Log", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Weight": 50.0, "Path": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)" } ], "IdentificationParameters": [ { "Name": "kcat OCT1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 200 mg, 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"Name": "MaxValue", "Value": 327757.510871441, "Unit": "1/min" } ] }, { "Name": "kcat OAT3", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Kanto 1981, 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IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 28, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 29, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 30, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 31, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 32, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 33, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 34, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 35, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 36, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 37, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 38, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#00C000", "LegendIndex": 39, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C00000", "LegendIndex": 40, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FFFF00", "LegendIndex": 41, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#008080", "LegendIndex": 42, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#800080", "LegendIndex": 43, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|Time", "Y": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 44, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|Time", "Y": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#80FF80", "LegendIndex": 45, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#808000", "LegendIndex": 46, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 47, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 48, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 49, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 50, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 51, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 52, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 53, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 54, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 55, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 56, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 57, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 58, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 59, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 60, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 61, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 62, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 63, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 64, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 65, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 66, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 67, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 68, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 69, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 70, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 71, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 72, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 73, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 74, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 75, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 76, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 77, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 78, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 79, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 80, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 81, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 82, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 83, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 84, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 85, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 86, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 87, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 88, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 89, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 90, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 91, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 92, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 93, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 94, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 95, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 96, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 97, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 98, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 99, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 100, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)|Time", "Y": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C04000", "LegendIndex": 101, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#00FF00", "LegendIndex": 102, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)|Time", "Y": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#808080", "LegendIndex": 103, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.|Time", "Y": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 104, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.|Time", "Y": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 105, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.|Time", "Y": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 106, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)|Time", "Y": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#00C000", "LegendIndex": 107, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)|Time", "Y": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. 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(n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)" }, { "Scaling": "Log", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Weight": 50.0, "Path": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)" } ], "IdentificationParameters": [ { "Name": "kcat OCT1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|OCT1-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|OCT1-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|OCT1-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|OCT1-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|OCT1-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|OCT1-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|OCT1-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|OCT1-Paper|kcat", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|OCT1-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 10911.84, "Unit": "1/min" }, { "Name": "MinValue", "Value": 327.0, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 327757.510871441, "Unit": "1/min" } ] }, { "Name": "kcat OAT3", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|OAT3-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|OAT3-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|OAT3-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|OAT3-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|OAT3-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|OAT3-Paper|kcat", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|OAT3-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 3268741.98, "Unit": "1/min" }, { "Name": "MinValue", "Value": 1111.0, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 110821186.8, "Unit": "1/min" } ] }, { "Name": "kcat MATE1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|MATE1-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|MATE1-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|MATE1-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 103.56, "Unit": "1/min" }, { "Name": "MinValue", "Value": 5.759, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 575.9049486992, "Unit": "1/min" } ] }, { "Name": "Specific intestinal permeability (transcellular)", "Scaling": "Log", "LinkedParameters": [ "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Bodemar 1981, n=10|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Burland 1975, caps|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Burland 1975, sol|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Kanto 1981, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Mihaly 1984, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg, Bodemar 1981, n=9|Cimetidine|Specific intestinal permeability (transcellular)", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|Specific intestinal permeability (transcellular)", "po 800 mg, Bodemar 1981, n=9|Cimetidine|Specific intestinal permeability (transcellular)", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|Specific intestinal permeability (transcellular)" ], "Parameters": [ { "Name": "Start value", "Value": 2.87E-06, "Unit": "cm/min" }, { "Name": "MinValue", "Value": 2.87E-07, "Unit": "cm/min" }, { "Name": "MaxValue", "Value": 2.8740150156E-05, "Unit": "cm/min" } ] }, { "Name": "Specific clearance", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Bodemar 1981, n=10|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Larsson 1982, n=9|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Mihaly 1984, n=6|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Bodemar 1981, n=10|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Burland 1975, caps|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Burland 1975, sol|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Kanto 1981, n=8|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200 mg, Mihaly 1984, n=8|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 400 mg, Bodemar 1981, n=9|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "po 800 mg, Bodemar 1981, n=9|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance" ], "Parameters": [ { "Name": "Start value", "Value": 0.1600808777, "Unit": "1/min" }, { "Name": "MinValue", "Value": 0.0016, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 1.600808777, "Unit": "1/min" } ] }, { "Name": "Ki", "Scaling": "Log", "LinkedParameters": [ "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|CYP3A4-Wrighton 1994|Ki" ], "Parameters": [ { "Name": "Start value", "Value": 268.0, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.268, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 2680.0, "Unit": "µmol/l" } ] } ] }, { "Name": "Parameter Identification 4 w. CYP3A4 Ki - multiple", "Simulations": [ "iv 100 mg (5 min), Grahnen 1979, n=3", "iv 200 mg (30 min),Morgan 1983, n=4", "iv 200 mg (5 min),Morgan 1983, n=6", "iv 200 mg, Bodemar 1981, n=10", "iv 200 mg, Larsson 1982, n=9", "iv 200 mg, Mihaly 1984, n=6", "iv 300 mg (2 min), Lebert 1981, n=1", "iv 300 mg (2 min), Walkenstein 1978, n=12", "po 200 mg (tab), Bodemar 1979 (fasted)", "po 200 mg (tab), Bodemar 1979 (fed)", "po 200 mg, Bodemar 1981, n=10", "po 200 mg, Burland 1975, caps", "po 200 mg, Burland 1975, sol", "po 200 mg, Kanto 1981, n=8", "po 200 mg, Mihaly 1984, n=8", "po 200/400 mg QID, Bodemar 1981 (fasted)", "po 300 mg (sol), Walkenstein 1978, n=24", "po 300 mg (tab), D'Angio 1986, n=6", "po 300 mg (tabl), Walkenstein 1978, n=12", "po 300 mg QID (sol), Barbhaiya 1995, n=18", "po 400 mg (tab), Bodemar 1979, n=10", "po 400 mg (tab), Somogyi 1981, n=8", "po 400 mg (tab),Grahnen 1979, n=3", "po 400 mg, Bodemar 1981, n=9", "po 800 mg (tab) qd, Tiseo 1998, n=18", "po 800 mg, Bodemar 1981, n=9", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ], "Configuration": { "LLOQMode": "OnlyObservedData", "RemoveLLOQMode": "NoTrailing", "CalculateJacobian": false, "Algorithm": { "Name": "Levenberg - Marquardt (MPFit)", "Properties": [ { "Name": "ftol", "Value": 0.001, "Type": "Double" }, { "Name": "xtol", "Value": 1E-06, "Type": "Double" }, { "Name": "gtol", "Value": 1E-10, "Type": "Double" }, { "Name": "stepfactor", "Value": 100.0, "Type": "Double" }, { "Name": "maxiter", "Value": 200.0, "Type": "Double" }, { "Name": "maxfev", "Value": 0.0, "Type": "Double" }, { "Name": "epsfcn", "Value": 1E-09, "Type": "Double" } ] }, "RunMode": { "NumberOfRuns": 40 } }, "OutputMappings": [ { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LH - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual KN - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LOE - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - IV 100 mg, urine mean % of dose - Cimetidine - IV - 100 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg (30 min),Morgan 1983, n=4|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 30 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=4)" }, { "Scaling": "Log", "Path": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 5 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - IV 200 mg - Cimetidine - IV - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - IV 200 mg, Urine - Cimetidine - IV - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - IV 200 mg, beginning of treatment - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Lebert 1981 - IV 300 mg - Cimetidine - IV - 300 mg - Plasma - agg. (n=8)", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 1 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 2 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 3 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 4 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 5 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 6 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 7 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)" }, { "Scaling": "Log", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Weight": 50.0, "Path": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)" } ], "IdentificationParameters": [ { "Name": "kcat OCT1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 200 mg, 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IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 22, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 23, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#C0C000", "LegendIndex": 24, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 25, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 26, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 27, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 28, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 29, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 30, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 31, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 32, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 33, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 34, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 35, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#8080FF", "LegendIndex": 36, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 37, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 38, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#00C000", "LegendIndex": 39, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C00000", "LegendIndex": 40, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)-Cimetidine-Kidney-Urine-ArithmeticMean", "X": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|Time", "Y": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)|ObservedData|Kidney|Urine|Cimetidine|ArithmeticMean", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FFFF00", "LegendIndex": 41, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#008080", "LegendIndex": 42, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|Time", "Y": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#800080", "LegendIndex": 43, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|Time", "Y": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 44, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|Time", "Y": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#80FF80", "LegendIndex": 45, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|Time", "Y": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#808000", "LegendIndex": 46, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 47, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 48, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 49, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 50, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 51, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 52, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 53, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 54, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 55, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 56, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 57, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.-Cimetidine-Kidney-Urine-Individual", "X": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv.|ObservedData|Kidney|Urine|Cimetidine|Individual", "CurveOptions": { "yAxisType": "Y2", "VisibleInLegend": false, "Color": "#FF8080", "LegendIndex": 58, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 59, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 60, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 61, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 62, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 63, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 64, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 65, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 66, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 67, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 68, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 69, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 70, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 71, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 72, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 73, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 74, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 75, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 76, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 77, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 78, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 79, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 80, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 81, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#ECD33A", "LegendIndex": 82, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 83, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 84, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 85, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 86, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 87, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.-Cimetidine-Peripheral Venous Blood-Plasma-Individual", "X": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|Time", "Y": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#0000C0", "LegendIndex": 88, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 89, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 90, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 91, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 92, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 93, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 94, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 95, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 96, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 97, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 98, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 99, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.-Cimetidine-Peripheral Venous Blood-Whole Blood-Individual", "X": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|Time", "Y": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv.|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|Individual", "CurveOptions": { "VisibleInLegend": false, "Color": "#804040", "LegendIndex": 100, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)|Time", "Y": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)|ObservedData|Peripheral Venous Blood|Plasma|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#C04000", "LegendIndex": 101, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)-Cimetidine-Peripheral Venous Blood-Whole Blood-ArithmeticMean", "X": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)|Time", "Y": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)|ObservedData|Peripheral Venous Blood|Whole Blood|Cimetidine|ArithmeticMean", "CurveOptions": { "VisibleInLegend": false, "Color": "#00FF00", "LegendIndex": 102, "LineStyle": "None", "Symbol": "Circle" } }, { "Name": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)-Cimetidine-Peripheral Venous Blood-Plasma-ArithmeticMean", "X": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)|Time", "Y": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. 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"X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00C000", "LegendIndex": 288 } }, { "Name": "5-po 200 mg, Burland 1975, sol-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 289 } }, { "Name": "5-Elliott 1984, Midazolam po + 200/400 mg cimetidine-Midazolam-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 290 } }, { "Name": "5-po 200 mg, Kanto 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 291 } }, { "Name": "5-po 300 mg (tab), D'Angio 1986, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 292 } }, { "Name": "5-po 200 mg (tab), Bodemar 1979 (fasted)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 293 } }, { "Name": "6-po 300 mg QID (sol), Barbhaiya 1995, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C04000", "LegendIndex": 294 } }, { "Name": "6-po 200 mg, Bodemar 1981, n=10-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 295 } }, { "Name": "6-po 200 mg, Bodemar 1981, n=10-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FFFF00", "LegendIndex": 296, "LineStyle": "Dash" } }, { "Name": "6-Elliott 1984, Midazolam po + 200/400 mg cimetidine-Midazolam-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "Elliott 1984, Midazolam po + 200/400 mg 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n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 300 } }, { "Name": "6-po 200 mg, Burland 1975, sol-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 301 } }, { "Name": "6-po 800 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 302 } }, { "Name": "6-po 800 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#804040", "LegendIndex": 303, "LineStyle": "Dash" } }, { "Name": "6-po 200/400 mg QID, Bodemar 1981 (fasted)-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808000", "LegendIndex": 304 } }, { "Name": "6-po 400 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 305 } }, { "Name": "6-po 400 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FFFF00", "LegendIndex": 306, "LineStyle": "Dash" } }, { "Name": "6-po 800 mg (tab) qd, Tiseo 1998, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 307 } }, { "Name": "6-iv 200 mg (5 min),Morgan 1983, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF00FF", "LegendIndex": 308 } }, { "Name": "6-po 200 mg, Burland 1975, caps-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 309 } }, { "Name": "6-iv 300 mg (2 min), Lebert 1981, n=1-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808080", "LegendIndex": 310 } }, { "Name": "6-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF0000", "LegendIndex": 311 } }, { "Name": "6-iv 100 mg (5 min), Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#0000FF", "LegendIndex": 312, "LineStyle": "Dash" } }, { "Name": "6-po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C0C000", "LegendIndex": 313 } }, { "Name": "6-po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#00C000", "LegendIndex": 314, "LineStyle": "Dash" } }, { "Name": "6-po 300 mg (tab), D'Angio 1986, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 315 } }, { "Name": "6-po 200 mg (tab), Bodemar 1979 (fed)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00C000", "LegendIndex": 316 } }, { "Name": "6-iv 200 mg, Mihaly 1984, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 317 } }, { "Name": "6-po 400 mg (tab), Bodemar 1979, n=10-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 318 } }, { "Name": "6-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#ECD33A", "LegendIndex": 319 } }, { "Name": "6-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FF8080", "LegendIndex": 320, "LineStyle": "Dash" } }, { "Name": "6-po 200 mg (tab), Bodemar 1979 (fasted)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 321 } }, { "Name": "6-iv 200 mg, Bodemar 1981, n=10-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF8000", "LegendIndex": 322 } }, { "Name": "6-iv 200 mg, Bodemar 1981, n=10-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#00C0C0", "LegendIndex": 323, "LineStyle": "Dash" } }, { "Name": "6-po 200 mg, Kanto 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 324 } }, { "Name": "6-po 400 mg (tab), Somogyi 1981, n=8-Cimetidine-Peripheral Venous 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"Y": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 334 } }, { "Name": "7-po 800 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 335 } }, { "Name": "7-po 800 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#804040", "LegendIndex": 336, "LineStyle": "Dash" } }, { "Name": "7-po 400 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 337 } }, { "Name": "7-po 400 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FFFF00", "LegendIndex": 338, "LineStyle": "Dash" } }, { "Name": "7-po 300 mg QID (sol), Barbhaiya 1995, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C04000", "LegendIndex": 339 } }, { "Name": "7-po 200 mg, Bodemar 1981, n=10-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 340 } }, { "Name": "7-po 200 mg, Bodemar 1981, n=10-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FFFF00", "LegendIndex": 341, "LineStyle": "Dash" } }, { "Name": "7-po 300 mg (tab), D'Angio 1986, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 342 } }, { "Name": "7-po 200 mg (tab), Bodemar 1979 (fed)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00C000", "LegendIndex": 343 } }, { "Name": "7-iv 200 mg, Mihaly 1984, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 344 } }, { "Name": "7-po 400 mg (tab), Bodemar 1979, n=10-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 345 } }, { "Name": "7-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, 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"Name": "13-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FF8080", "LegendIndex": 557, "LineStyle": "Dash" } }, { "Name": "13-po 200 mg (tab), Bodemar 1979 (fasted)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 558 } }, { "Name": "13-iv 200 mg, Bodemar 1981, n=10-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF8000", "LegendIndex": 559 } }, { "Name": 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"X": "Time", "Y": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 578 } }, { "Name": "13-po 200 mg, Burland 1975, sol-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 579 } }, { "Name": "13-po 800 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 580 } }, { "Name": "13-po 800 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 800 mg, Bodemar 1981, 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"Color": "#C04000", "LegendIndex": 644, "LineStyle": "Dash" } }, { "Name": "15-po 800 mg (tab) qd, Tiseo 1998, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 645 } }, { "Name": "15-iv 200 mg (5 min),Morgan 1983, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF00FF", "LegendIndex": 646 } }, { "Name": "15-po 200 mg, Burland 1975, caps-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", 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"Name": "16-po 200/400 mg QID, Bodemar 1981 (fasted)-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808000", "LegendIndex": 654 } }, { "Name": "16-Elliott 1984, Midazolam po + 200/400 mg cimetidine-Midazolam-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 655 } }, { "Name": "16-iv 200 mg (30 min),Morgan 1983, n=4-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg (30 min),Morgan 1983, n=4|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008000", "LegendIndex": 656 } }, { 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n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 675 } }, { "Name": "16-po 200 mg (tab), Bodemar 1979 (fasted)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 676 } }, { "Name": "16-iv 200 mg, Bodemar 1981, n=10-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF8000", "LegendIndex": 677 } }, { "Name": "16-iv 200 mg, Bodemar 1981, n=10-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction 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"Y2", "Visible": false, "Color": "#00C000", "LegendIndex": 684, "LineStyle": "Dash" } }, { "Name": "16-po 200 mg, Kanto 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 685 } }, { "Name": "16-po 400 mg (tab), Somogyi 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808080", "LegendIndex": 686 } }, { "Name": "16-po 400 mg (tab), Bodemar 1979, n=10-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 687 } }, { "Name": "16-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#ECD33A", "LegendIndex": 688 } }, { "Name": "16-po 300 mg (sol), Walkenstein 1978, n=24-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FF8080", "LegendIndex": 689, "LineStyle": "Dash" } }, { "Name": "17-po 200/400 mg QID, Bodemar 1981 (fasted)-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808000", "LegendIndex": 690 } }, { "Name": "17-po 800 mg (tab) qd, Tiseo 1998, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 691 } }, { "Name": "17-po 200 mg, Burland 1975, caps-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 692 } }, { "Name": "17-iv 300 mg (2 min), Lebert 1981, n=1-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808080", "LegendIndex": 693 } }, { "Name": "17-po 300 mg (tabl), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 694 } }, { "Name": "17-Elliott 1984, Midazolam po + 200/400 mg cimetidine-Midazolam-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 695 } }, { "Name": "17-iv 200 mg (30 min),Morgan 1983, n=4-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg (30 min),Morgan 1983, n=4|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008000", "LegendIndex": 696 } }, { "Name": "17-po 200 mg, Kanto 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 697 } }, { "Name": "17-po 400 mg (tab), Somogyi 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#808080", "LegendIndex": 698 } }, { "Name": "17-po 200 mg, Burland 1975, sol-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 699 } }, { "Name": "17-po 800 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 700 } }, { "Name": "17-po 800 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#804040", "LegendIndex": 701, "LineStyle": "Dash" } }, { "Name": "17-po 300 mg QID (sol), Barbhaiya 1995, n=18-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C04000", "LegendIndex": 702 } }, { "Name": "17-po 200 mg, Bodemar 1981, n=10-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 703 } }, { "Name": "17-po 200 mg, Bodemar 1981, n=10-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FFFF00", "LegendIndex": 704, "LineStyle": "Dash" } }, { "Name": "17-po 300 mg (tab), D'Angio 1986, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 705 } }, { "Name": "17-iv 300 mg (2 min), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous 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"X": "Time", "Y": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF8000", "LegendIndex": 718 } }, { "Name": "17-iv 200 mg, Bodemar 1981, n=10-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#00C0C0", "LegendIndex": 719, "LineStyle": "Dash" } }, { "Name": "17-po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C0C000", "LegendIndex": 720 } }, { "Name": "17-po 400 mg (tab),Grahnen 1979, n=3-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#00C000", "LegendIndex": 721, "LineStyle": "Dash" } }, { "Name": "17-po 400 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 722 } }, { "Name": "17-po 400 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#FFFF00", "LegendIndex": 723, "LineStyle": "Dash" } }, { "Name": "17-po 200 mg (tab), Bodemar 1979 (fed)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00C000", "LegendIndex": 724 } }, { "Name": "17-iv 200 mg, Mihaly 1984, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#00FF00", "LegendIndex": 725 } }, { "Name": "18-Elliott 1984, Midazolam po + 200/400 mg cimetidine-Midazolam-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 726 } }, { "Name": "18-po 200 mg, Kanto 1981, n=8-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 727 } }, { "Name": "18-po 200 mg, Burland 1975, caps-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#008080", "LegendIndex": 728 } }, { "Name": "18-iv 200 mg (5 min),Morgan 1983, n=6-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#FF00FF", "LegendIndex": 729 } }, { "Name": "18-po 200/400 mg QID, Bodemar 1981 (fasted)-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 200/400 mg QID, Bodemar 1981 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800 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#800080", "LegendIndex": 770 } }, { "Name": "19-po 800 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction excreted to urine", "X": "Time", "Y": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "CurveOptions": { "yAxisType": "Y2", "Visible": false, "Color": "#804040", "LegendIndex": 771, "LineStyle": "Dash" } }, { "Name": "19-po 400 mg, Bodemar 1981, n=9-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#C00000", "LegendIndex": 772 } }, { "Name": "19-po 400 mg, Bodemar 1981, n=9-Cimetidine-Kidney-Urine-Fraction 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n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#80FF80", "LegendIndex": 1065 } }, { "Name": "27-po 300 mg (tabl), Walkenstein 1978, n=12-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#804040", "LegendIndex": 1066 } }, { "Name": "27-po 200 mg (tab), Bodemar 1979 (fasted)-Cimetidine-Peripheral Venous Blood-Whole Blood-Concentration", "X": "Time", "Y": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "CurveOptions": { "Visible": false, "Color": "#0000C0", "LegendIndex": 1067 } }, { "Name": "27-iv 200 mg, Bodemar 1981, n=10-Cimetidine-Peripheral Venous Blood-Plasma-Concentration", "X": "Time", "Y": "iv 200 mg, Bodemar 1981, 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CYP3A4 Ki - optimized start values", "Simulations": [ "iv 100 mg (5 min), Grahnen 1979, n=3", "iv 200 mg (30 min),Morgan 1983, n=4", "iv 200 mg (5 min),Morgan 1983, n=6", "iv 200 mg, Bodemar 1981, n=10", "iv 200 mg, Larsson 1982, n=9", "iv 200 mg, Mihaly 1984, n=6", "iv 300 mg (2 min), Lebert 1981, n=1", "iv 300 mg (2 min), Walkenstein 1978, n=12", "po 200 mg (tab), Bodemar 1979 (fasted)", "po 200 mg (tab), Bodemar 1979 (fed)", "po 200 mg, Bodemar 1981, n=10", "po 200 mg, Burland 1975, caps", "po 200 mg, Burland 1975, sol", "po 200 mg, Kanto 1981, n=8", "po 200 mg, Mihaly 1984, n=8", "po 200/400 mg QID, Bodemar 1981 (fasted)", "po 300 mg (sol), Walkenstein 1978, n=24", "po 300 mg (tab), D'Angio 1986, n=6", "po 300 mg (tabl), Walkenstein 1978, n=12", "po 300 mg QID (sol), Barbhaiya 1995, n=18", "po 400 mg (tab), Bodemar 1979, n=10", "po 400 mg (tab), Somogyi 1981, n=8", "po 400 mg (tab),Grahnen 1979, n=3", "po 400 mg, Bodemar 1981, n=9", "po 800 mg (tab) qd, Tiseo 1998, n=18", "po 800 mg, Bodemar 1981, n=9", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ], "Configuration": { "LLOQMode": "OnlyObservedData", "RemoveLLOQMode": "NoTrailing", "CalculateJacobian": true, "Algorithm": { "Name": "Levenberg - Marquardt (MPFit)", "Properties": [ { "Name": "ftol", "Value": 0.001, "Type": "Double" }, { "Name": "xtol", "Value": 1E-06, "Type": "Double" }, { "Name": "gtol", "Value": 1E-10, "Type": "Double" }, { "Name": "stepfactor", "Value": 100.0, "Type": "Double" }, { "Name": "maxiter", "Value": 200.0, "Type": "Double" }, { "Name": "maxfev", "Value": 0.0, "Type": "Double" }, { "Name": "epsfcn", "Value": 1E-09, "Type": "Double" } ] } }, "OutputMappings": [ { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LH - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual KN - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Log", "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - IV 100 mg, Individual LOE - Cimetidine - IV - 100 mg - Plasma - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 100 mg (5 min), Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - IV 100 mg, urine mean % of dose - Cimetidine - IV - 100 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg (30 min),Morgan 1983, n=4|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 30 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=4)" }, { "Scaling": "Log", "Path": "iv 200 mg (5 min),Morgan 1983, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Morgan 1983 - IV 200 mg 5 min - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - IV 200 mg - Cimetidine - IV - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - IV 200 mg, Urine - Cimetidine - IV - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "iv 200 mg, Larsson 1982, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 200 mg, Larsson 1982, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Larsson 1982 - IV 200 mg in normal renal function group - Cimetidine - IV - 200 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "iv 200 mg, Mihaly 1984, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - IV 200 mg, beginning of treatment - Cimetidine - IV - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Lebert 1981, n=1|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Lebert 1981 - IV 300 mg - Cimetidine - IV - 300 mg - Plasma - agg. (n=8)", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 1 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 2 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 3 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 4 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 5 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 6 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 7 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 8 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 9 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 10 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 11 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - IV 300 mg urine Subject 12 - Cimetidine - IV - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 1 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 2 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 3 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 4 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 5 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 6 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 7 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 8 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 9 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 10 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 11 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "iv 300 mg (2 min), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - IV 300 mg Subject 12 - Cimetidine - IV - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fasted - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg (tab), Bodemar 1979 (fed)|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 200 mg fed - Cimetidine - PO - 200 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Bodemar 1981, n=10|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 200 mg, Bodemar 1981, n=10|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 200 mg, Urine - Cimetidine - PO - 200 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, caps|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg caps - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Burland 1975, sol|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Burland 1975 - PO 200 mg sol - Cimetidine - PO - 200 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 200 mg, Kanto 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanto 1981 - PO 200 mg - Cimetidine - PO - 200 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 200 mg, Mihaly 1984, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Mihaly 1984 - PO 200 mg, beginning of treatment - Cimetidine - PO - 200 mg - Plasma - agg. (n=6)" }, { "Scaling": "Log", "Path": "po 200/400 mg QID, Bodemar 1981 (fasted)|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - 200/400 mg QID - Cimetidine - PO - 200/400 mg - Plasma - agg. (n=10)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 1 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 2 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 3 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 4 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 5 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 6 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 7 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 8 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 9 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 10 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 11 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Walkenstein 1978 - PO 300 mg urine Subject 12 - Cimetidine - PO - 300 mg - Urine - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 1 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 2 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 3 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 4 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 5 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 6 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 7 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 8 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 9 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 10 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 11 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 12 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (sol), Walkenstein 1978, n=24|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg sol Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 1 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 2 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 3 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 4 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 5 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tab), D'Angio 1986, n=6|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "D'Angio 1986 - PO 300 mg tab subject 6 - Cimetidine - PO - 300 mg - Serum - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 13 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 14 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 15 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 16 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 17 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 18 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 19 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 20 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 21 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 22 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 23 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg (tabl), Walkenstein 1978, n=12|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Walkenstein 1978 - PO 300 mg tab Subject 24 - Cimetidine - PO - 300 mg - Whole Blood - indiv." }, { "Scaling": "Log", "Path": "po 300 mg QID (sol), Barbhaiya 1995, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbhaiya 1995 - PO 300 mg QID - Cimetidine - PO - 300 mg - Plasma - agg. (n=18)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Bodemar 1979, n=10|Organism|PeripheralVenousBlood|Cimetidine|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Bodemar 1979 - PO 400 mg - Cimetidine - PO - 400 mg - Whole Blood - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg (tab), Somogyi 1981, n=8|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Somogyi 1981 - PO 400 mg tab - Cimetidine - PO - 400 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LH - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual LOE - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Log", "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Grahnen 1979 - PO 400 mg, Individual UB - Cimetidine - PO - 400 mg - Plasma - indiv.", "Weights": [ 0.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0 ] }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg (tab),Grahnen 1979, n=3|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Grahnen 1979 - PO 400 mg, urine mean % of dose - Cimetidine - PO - 400 mg - Urine - agg. (n=10)" }, { "Scaling": "Log", "Path": "po 400 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 400 mg - Cimetidine - PO - 400 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 400 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 400 mg, Urine - Cimetidine - PO - 400 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Path": "po 800 mg (tab) qd, Tiseo 1998, n=18|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Tiseo 1998 - PO 800 mg QD - Cimetidine - PO - 800 mg - Plasma - agg. (n=19)" }, { "Scaling": "Log", "Path": "po 800 mg, Bodemar 1981, n=9|Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)", "ObservedData": "Bodemar 1981 - PO 800 mg - Cimetidine - PO - 800 mg - Plasma - agg. (n=9)" }, { "Scaling": "Linear", "Weight": 5.0, "Path": "po 800 mg, Bodemar 1981, n=9|Organism|Kidney|Urine|Cimetidine|Fraction excreted to urine", "ObservedData": "Bodemar 1981 - PO 800 mg, Urine - Cimetidine - PO - 800 mg - Urine - agg. (n=9)" }, { "Scaling": "Log", "Weight": 50.0, "Path": "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)" } ], "IdentificationParameters": [ { "Name": "kcat OCT1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OCT1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OCT1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OCT1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OCT1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OCT1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OCT1-Paper|kcat", "po 200 mg, 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"Name": "MaxValue", "Value": 327757.510871441, "Unit": "1/min" } ] }, { "Name": "kcat OAT3", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|OAT3-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|OAT3-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|OAT3-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|OAT3-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|OAT3-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|OAT3-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|OAT3-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|OAT3-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|OAT3-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|OAT3-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|OAT3-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|OAT3-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|OAT3-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|OAT3-Paper|kcat", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|OAT3-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 645975.63, "Unit": "1/min" }, { "Name": "MinValue", "Value": 1111.0, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 110821186.8, "Unit": "1/min" } ] }, { "Name": "kcat MATE1", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine|MATE1-Paper|kcat", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Larsson 1982, n=9|Cimetidine|MATE1-Paper|kcat", "iv 200 mg, Mihaly 1984, n=6|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Lebert 1981, n=1|Cimetidine|MATE1-Paper|kcat", "iv 300 mg (2 min), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Bodemar 1981, n=10|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, caps|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Burland 1975, sol|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Kanto 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 200 mg, Mihaly 1984, n=8|Cimetidine|MATE1-Paper|kcat", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|MATE1-Paper|kcat", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|MATE1-Paper|kcat", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|MATE1-Paper|kcat", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|MATE1-Paper|kcat", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|MATE1-Paper|kcat", "po 400 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|MATE1-Paper|kcat", "po 800 mg, Bodemar 1981, n=9|Cimetidine|MATE1-Paper|kcat", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|MATE1-Paper|kcat" ], "Parameters": [ { "Name": "Start value", "Value": 206.54, "Unit": "1/min" }, { "Name": "MinValue", "Value": 5.759, "Unit": "1/min" }, { "Name": "MaxValue", "Value": 575.9049486992, "Unit": "1/min" } ] }, { "Name": "Specific intestinal permeability (transcellular)", "Scaling": "Log", "LinkedParameters": [ "po 200 mg (tab), Bodemar 1979 (fasted)|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg (tab), Bodemar 1979 (fed)|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Bodemar 1981, n=10|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Burland 1975, caps|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Burland 1975, sol|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Kanto 1981, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 200 mg, Mihaly 1984, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 200/400 mg QID, Bodemar 1981 (fasted)|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (sol), Walkenstein 1978, n=24|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (tab), D'Angio 1986, n=6|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg (tabl), Walkenstein 1978, n=12|Cimetidine|Specific intestinal permeability (transcellular)", "po 300 mg QID (sol), Barbhaiya 1995, n=18|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab), Bodemar 1979, n=10|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab), Somogyi 1981, n=8|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg (tab),Grahnen 1979, n=3|Cimetidine|Specific intestinal permeability (transcellular)", "po 400 mg, Bodemar 1981, n=9|Cimetidine|Specific intestinal permeability (transcellular)", "po 800 mg (tab) qd, Tiseo 1998, n=18|Cimetidine|Specific intestinal permeability (transcellular)", "po 800 mg, Bodemar 1981, n=9|Cimetidine|Specific intestinal permeability (transcellular)", "Elliott 1984, Midazolam po + 200/400 mg cimetidine|Cimetidine|Specific intestinal permeability (transcellular)" ], "Parameters": [ { "Name": "Start value", "Value": 2.43E-06, "Unit": "cm/min" }, { "Name": "MinValue", "Value": 2.87E-07, "Unit": "cm/min" }, { "Name": "MaxValue", "Value": 2.8740150156E-05, "Unit": "cm/min" } ] }, { "Name": "Specific clearance", "Scaling": "Log", "LinkedParameters": [ "iv 100 mg (5 min), Grahnen 1979, n=3|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg (30 min),Morgan 1983, n=4|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg (5 min),Morgan 1983, n=6|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Bodemar 1981, n=10|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, Larsson 1982, n=9|Cimetidine-Total Hepatic Clearance-Somogyi 1983|Specific clearance", "iv 200 mg, 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