{ "Version": 79, "ExpressionProfiles": [ { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP3A4", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "CYP3A4|Reference concentration", "Value": 4.32, "Unit": "µmol/l" }, { "Path": "CYP3A4|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "CYP3A4|t1/2 (liver)", "Value": 36.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", "Value": 0.0041682898325 }, { "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", "Value": 0.00078691079081 }, { "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", "Value": 0.0053603428126 }, { "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression", "Value": 0.00042695753798 }, { "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression", "Value": 0.0727697702 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome", "Ontogeny": { "Name": "CYP3A4" } }, { "Type": "Enzyme", "Species": "Human", "Molecule": "AADAC", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "AADAC|Reference concentration", "Value": 1.0, "Unit": "µmol/l" }, { "Path": "AADAC|Relative expression in blood cells", "Value": 3.9102564103E-05 }, { "Path": "AADAC|Relative expression in plasma", "Value": 3.9102564103E-05 }, { "Path": "AADAC|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "AADAC|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|AADAC|Relative expression", "Value": 4.8717948718E-05 }, { "Path": "Organism|Brain|Intracellular|AADAC|Relative expression", "Value": 3.9743589744E-05 }, { "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression", "Value": 0.0011923076923 }, { "Path": "Organism|Heart|Intracellular|AADAC|Relative expression", "Value": 0.0026602564103 }, { "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression", "Value": 5.7051282051E-05 }, { "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression", "Value": 0.00010384615385 }, { "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|AADAC|Relative expression", "Value": 0.0269230769 }, { "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression", "Value": 0.00020833333333 }, { "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression", "Value": 0.1474358974 }, { "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression", "Value": 0.2544871795 }, { "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression", "Value": 0.00037115384615 }, { "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression", "Value": 0.0775641026 } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" }, { "Type": "OtherProtein", "Species": "Human", "Molecule": "GABRG2", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "GABRG2|Reference concentration", "Value": 1.04099689, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "GABRG2|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "GABRG2|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|GABRG2|Relative expression", "Value": 1.0 } ], "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" }, { "Type": "Transporter", "Species": "Human", "Molecule": "OATP1B1", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "OATP1B1|Reference concentration", "Value": 1.0, "Unit": "µmol/l" }, { "Path": "OATP1B1|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "OATP1B1|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", "Value": 0.00014166666667 }, { "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", "Value": 0.0141666667 }, { "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", "Value": 0.0008253968254 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", "Value": 4.0079365079E-05 }, { "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", "Value": 0.00064682539683 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "InfluxPlasmaToBloodCells" }, { "Name": "VascularEndothelium", "TransportDirection": "InfluxPlasmaToInterstitial" } ] }, { "Type": "Enzyme", "Species": "Human", "Molecule": "UGT1A4", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|UGT1A4|Relative expression", "Value": 1.0 }, { "Path": "UGT1A4|Reference concentration", "Value": 2.32, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "UGT1A4|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "UGT1A4|t1/2 (liver)", "Value": 36.0, "Unit": "h" } ], "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome", "Ontogeny": { "Name": "UGT1A4" } }, { "Type": "OtherProtein", "Species": "Human", "Molecule": "ATP1A2", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "ATP1A2|Reference concentration", "Value": 0.39140774, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "ATP1A2|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "ATP1A2|t1/2 (liver)", "Value": 36.0, "Unit": "h" }, { "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", "Value": 0.0062154033171 }, { "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", "Value": 1.0 }, { "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", "Value": 0.0508741242 }, { "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", "Value": 0.3179118843 }, { "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", "Value": 0.0158938619 }, { "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", "Value": 0.0786998764 }, { "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", "Value": 0.0223784807 }, { "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", "Value": 0.0223784807 }, { "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", "Value": 0.0272345453 }, { "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", "Value": 0.7034193524 }, { "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", "Value": 0.0073903254795 }, { "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", "Value": 0.0389467988 }, { "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", "Value": 0.0501579923 }, { "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", "Value": 0.0103243118 }, { "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", "Value": 0.0309435884 } ], "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" }, { "Type": "Transporter", "Species": "Human", "Molecule": "P-gp", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "Organism|Bone|Intracellular|P-gp|Relative expression", "Value": 0.0242518189 }, { "Path": "Organism|Brain|Intracellular|P-gp|Relative expression", "Value": 0.07608904 }, { "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression", "Value": 0.017417973 }, { "Path": "Organism|Heart|Intracellular|P-gp|Relative expression", "Value": 0.0419198106 }, { "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression", "Value": 0.7092198582 }, { "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression", "Value": 0.1108416465 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression", "Value": 0.1916810428 }, { "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression", "Value": 0.1916810428 }, { "Path": "Organism|Lung|Intracellular|P-gp|Relative expression", "Value": 0.0657549316 }, { "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression", "Value": 0.0128342959 }, { "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression", "Value": 0.0142510689 }, { "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression", "Value": 0.2808543974 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression", "Value": 0.0742555691 }, { "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression", "Value": 0.0260852897 }, { "Path": "P-gp|Reference concentration", "Value": 1.41, "Unit": "µmol/l", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "P-gp|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "P-gp|t1/2 (liver)", "Value": 36.0, "Unit": "h" } ], "TransportType": "Efflux", "Expression": [ { "Name": "Bone", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "EffluxBrainInterstitialToPlasma", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "EffluxBrainTissueToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", 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(n=9)" ] }, { "Name": "Kurata 2002", "Classifications": [ { "Name": "PO", "Classifications": [ { "Name": "Control phase", "Classifiables": [ "Kurata 2002 - G/G2677C/C3435_Digoxin day 1 - Digoxin - PO - 0.5 mg - Serum - agg. (n=5)", "Kurata 2002 - T/T2677T/T3435_Digoxin day 1 - Digoxin - PO - 0.5 mg - serum - agg. (n=5)", "Kurata 2002 - G/T2677C/T3435_Digoxin day 1 - Digoxin - PO - 0.5 mg - serum - agg. (n=5)" ] }, { "Name": "Treatment phase", "Classifiables": [ "Kurata 2002 - G/G2677C/C3435_Digoxin day 16 + Clarithromycin - Digoxin - PO - 0.25 mg - serum - agg. (n=5)", "Kurata 2002 - T/T2677T/T3435_Digoxin day 16 + Clarithromycin - Digoxin - PO - 0.25 mg - serum - agg. (n=5)", "Kurata 2002 - G/T2677C/T3435_Digoxin day 16 + Clarithromycin - Digoxin - PO - 0.25 mg - serum - agg. (n=5)" ] } ] }, { "Name": "IV", "Classifications": [ { "Name": "Control phase", "Classifiables": [ "Kurata 2002 - G/G2677C/C3435_Digoxin day 1 - Digoxin - IV - 0.5 mg - serum - agg. (n=5)", "Kurata 2002 - T/T2677T/T3435_Digoxin day 1 - Digoxin - IV - 0.5 mg - serum - agg. (n=5)", "Kurata 2002 - G/T2677C/T3435_Digoxin day 1 - Digoxin - IV - 0.5 mg - serum - agg. (n=5)" ] }, { "Name": "Treatment phase", "Classifiables": [ "Kurata 2002 - G/G2677C/C3435_Digoxin day 16 + Clarithromycin - Digoxin - IV - 0.25 mg - serum - agg. (n=5)", "Kurata 2002 - T/T2677T/T3435_Digoxin day 16 + Clarithromycin - Digoxin - IV - 0.25 mg - serum - agg. (n=5)", "Kurata 2002 - G/T2677C/T3435_Digoxin day 16 + Clarithromycin - Digoxin - IV - 0.25 mg - serum - agg. (n=5)" ] } ] } ] }, { "Name": "Gurley 2006", "Classifiables": [ "Gurley 2006 - day 1 plasma before Clarithromycin - Digoxin - PO - 0.4 mg - serum - agg. (n=16)", "Gurley 2006 - day 7 plasma + Clarithromycin - Digoxin - PO - 0.4 mg - serum - agg. (n=16)" ] }, { "Name": "Gurley 2007", "Classifiables": [ "Gurley 2007 - control to Clarithromycin - Digoxin - PO - 0.5 mg - serum - agg. (n=20)", "Gurley 2007 - Digoxin + Clarithromycin - Digoxin - PO - 0.5 mg - serum - agg. (n=20)" ] }, { "Name": "Rengelshausen 2003", "Classifiables": [ "Rengelshausen 2003 - 0.01mg/kg iv with clarithromycin - Digoxin - IV - 0.01 mg/kg - Plasma - agg. (n=3)", "Rengelshausen 2003 - 0.75mg po with clarithromycin - Digoxin - PO - 0.75 mg - Plasma - agg. (n=12)", "Rengelshausen 2003 - 0.01mg/kg iv with placebo - Digoxin - IV - 0.01 mg/kg - Plasma - agg. (n=3)", "Rengelshausen 2003 - 0.75mg po with placebo - Digoxin - PO - 0.75 mg - Plasma - agg. (n=12)", "Rengelshausen 2003 - Clarithromycin Day 2 - Clarithromycin - PO - 250 mg - Plasma - agg. (n=12)" ] } ] }