{
  "Version": 78,
  "Individuals": [
    {
      "Name": "European (P-gp modified, CYP3A4 36 h)",
      "Seed": 1745497687,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B3|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B3|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B3|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Bone|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0326065214
        },
        {
          "Path": "Organism|Bone|Intracellular|P-gp|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B3|Relative expression",
          "Value": 0.026415244
        },
        {
          "Path": "Organism|Brain|Intracellular|P-gp|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B3|Relative expression",
          "Value": 0.041669701
        },
        {
          "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0574843621
        },
        {
          "Path": "Organism|Heart|Intracellular|P-gp|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Kidney|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0249619939
        },
        {
          "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0081029350428
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0081029350428
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0081029350428
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0081029350428
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0081029350428
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B3|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B3|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0227975502
        },
        {
          "Path": "Organism|Lung|Intracellular|P-gp|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0151497833
        },
        {
          "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Pancreas|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0094097200792
        },
        {
          "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|Skin|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0107729681
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0194716112
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0194716112
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0194716112
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0194716112
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0194716112
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0194716112
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Spleen|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0113959291
        },
        {
          "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        },
        {
          "Path": "Organism|Stomach|Intracellular|OATP1B3|Relative expression",
          "Value": 0.0102007599
        },
        {
          "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "P-gp|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "P-gp|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "P-gp|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "P-gp",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ]
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "OATP1B3",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Clarithromycin",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.3,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Lappin 2011"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.3,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Chu 1993"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 12.17,
              "Unit": "mg/ml",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Salem 2003"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 2.4,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Salem 2003"
              }
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "fit",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 1.23E-06,
              "Unit": "dm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Description": "optimized"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.99,
          "ValueOrigin": {
            "Source": "Publication",
            "Description": "McFarland 1997"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "fit",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 0.0,
              "Unit": "pmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 48.7,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Rodrigues 1997"
              }
            },
            {
              "Name": "kcat",
              "Value": 76.5,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification"
              }
            }
          ]
        },
        {
          "InternalName": "KidneyClearance",
          "DataSource": "fitted",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Body weight",
              "Value": 71.5,
              "Unit": "kg",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Blood flow rate (kidney)",
              "Value": 1.31,
              "Unit": "l/min",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Fraction unbound (experiment)",
              "Value": 0.4
            },
            {
              "Name": "Plasma clearance",
              "Value": 1.75,
              "Unit": "ml/min/kg"
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Eberl (2007)",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 4.1,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Eberl 2007"
              }
            }
          ]
        },
        {
          "InternalName": "IrreversibleInhibition",
          "DataSource": "fitted",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "kinact",
              "Value": 0.04,
              "Unit": "1/min"
            },
            {
              "Name": "K_kinact_half",
              "Value": 6.04,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Vermeer 2016",
          "Molecule": "OATP1B1",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 5.3,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Vermeer 2016"
              }
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Vermeer 2016",
          "Molecule": "OATP1B3",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 14.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Vermeer 2016"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 747.9534,
          "Unit": "g/mol"
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "Tablet Clarithromycin",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 5.0,
          "Unit": "min"
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 2.9
        },
        {
          "Name": "Use as suspension",
          "Value": 0.0
        }
      ]
    }
  ],
  "Protocols": [
    {
      "Name": "Clarithromycin iv, Chu1992, 250 mg, 0.75 h",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 250.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 45.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Clarithromycin po, Abduljalil 2009, 500 mg 3.5 d",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 500.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
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