{
"Version": 79,
"ExpressionProfiles": [
{
"Type": "Transporter",
"Species": "Human",
"Molecule": "P-gp",
"Category": "European (Pgp modified)",
"Parameters": [
{
"Path": "Organism|Bone|Intracellular|P-gp|Relative expression",
"Value": 0.0242518189
},
{
"Path": "Organism|Brain|Intracellular|P-gp|Relative expression",
"Value": 0.07608904
},
{
"Path": "Organism|Gonads|Intracellular|P-gp|Relative expression",
"Value": 0.017417973
},
{
"Path": "Organism|Heart|Intracellular|P-gp|Relative expression",
"Value": 0.0419198106
},
{
"Path": "Organism|Kidney|Intracellular|P-gp|Relative expression",
"Value": 0.7092198582
},
{
"Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression",
"Value": 0.1108416465
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression",
"Value": 0.3971631206
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression",
"Value": 0.3971631206
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression",
"Value": 0.3971631206
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression",
"Value": 0.3971631206
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression",
"Value": 0.1916810428
},
{
"Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression",
"Value": 0.1916810428
},
{
"Path": "Organism|Lung|Intracellular|P-gp|Relative expression",
"Value": 0.0657549316
},
{
"Path": "Organism|Muscle|Intracellular|P-gp|Relative expression",
"Value": 0.0128342959
},
{
"Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression",
"Value": 0.0142510689
},
{
"Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression",
"Value": 0.2808543974
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Spleen|Intracellular|P-gp|Relative expression",
"Value": 0.0742555691
},
{
"Path": "Organism|Stomach|Intracellular|P-gp|Relative expression",
"Value": 0.0260852897
},
{
"Path": "P-gp|Reference concentration",
"Value": 1.41,
"Unit": "µmol/l",
"ValueOrigin": {
"Source": "ParameterIdentification"
}
},
{
"Path": "P-gp|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "P-gp|t1/2 (liver)",
"Value": 36.0,
"Unit": "h"
}
],
"TransportType": "Efflux",
"Expression": [
{
"Name": "Bone",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Brain",
"TransportDirection": "EffluxBrainInterstitialToPlasma",
"CompartmentName": "Plasma"
},
{
"Name": "Brain",
"TransportDirection": "EffluxBrainTissueToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "Fat",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Gonads",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Heart",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Kidney",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "Kidney",
"TransportDirection": "ExcretionKidney",
"CompartmentName": "Intracellular"
},
{
"Name": "Stomach",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "SmallIntestine",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Duodenum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "Duodenum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "UpperJejunum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "UpperJejunum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "LowerJejunum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "LowerJejunum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "UpperIleum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "UpperIleum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "LowerIleum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "LowerIleum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "LargeIntestine",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Caecum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "Caecum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "ColonAscendens",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "ColonAscendens",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "ColonTransversum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "ColonTransversum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "ColonDescendens",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "ColonDescendens",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "ColonSigmoid",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "ColonSigmoid",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "Rectum",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "Rectum",
"TransportDirection": "EffluxMucosaIntracellularToLumen",
"CompartmentName": "Intracellular"
},
{
"Name": "Periportal",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "Periportal",
"TransportDirection": "ExcretionLiver",
"CompartmentName": "Intracellular"
},
{
"Name": "Pericentral",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Interstitial"
},
{
"Name": "Pericentral",
"TransportDirection": "ExcretionLiver",
"CompartmentName": "Intracellular"
},
{
"Name": "Lung",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Muscle",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Pancreas",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Skin",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "Spleen",
"TransportDirection": "EffluxIntracellularToInterstitial",
"CompartmentName": "Intracellular"
},
{
"Name": "BloodCells",
"TransportDirection": "EffluxBloodCellsToPlasma"
},
{
"Name": "VascularEndothelium",
"TransportDirection": "EffluxInterstitialToPlasma"
}
],
"Ontogeny": {
"Name": "P-gp",
"Table": {
"Name": "TableFormula",
"Percentile": 0.0,
"DistributionMetaData": [
{
"Mean": 1E-14,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 1.915059E-05,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 5.486795E-05,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.0001571905,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.0004502473,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.001288958,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.00368424,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.01048397,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.02946235,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.0800178,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.1994918,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.4165768,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.6716791,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.8542612,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.943803,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.9796414,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.992799,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.9974749,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.9991173,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.9996917,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.9998924,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.9999624,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 0.9999869,
"Deviation": 1.6,
"Distribution": "LogNormal"
},
{
"Mean": 1.0,
"Deviation": 1.6,
"Distribution": "LogNormal"
}
],
"XName": "Postmenstrual age",
"XDimension": "Age in years",
"XUnit": "year(s)",
"YName": "P-gp",
"YDimension": "Fraction",
"UseDerivedValues": false,
"Points": [
{
"X": 0.0,
"Y": 1E-14,
"RestartSolver": false
},
{
"X": 0.08333334,
"Y": 1.915059E-05,
"RestartSolver": false
},
{
"X": 0.1666667,
"Y": 5.486795E-05,
"RestartSolver": false
},
{
"X": 0.25,
"Y": 0.0001571905,
"RestartSolver": false
},
{
"X": 0.3333333,
"Y": 0.0004502473,
"RestartSolver": false
},
{
"X": 0.4166667,
"Y": 0.001288958,
"RestartSolver": false
},
{
"X": 0.5,
"Y": 0.00368424,
"RestartSolver": false
},
{
"X": 0.5833333,
"Y": 0.01048397,
"RestartSolver": false
},
{
"X": 0.6666667,
"Y": 0.02946235,
"RestartSolver": false
},
{
"X": 0.75,
"Y": 0.0800178,
"RestartSolver": false
},
{
"X": 0.8333333,
"Y": 0.1994918,
"RestartSolver": false
},
{
"X": 0.9166667,
"Y": 0.4165768,
"RestartSolver": false
},
{
"X": 1.0,
"Y": 0.6716791,
"RestartSolver": false
},
{
"X": 1.083333,
"Y": 0.8542612,
"RestartSolver": false
},
{
"X": 1.166667,
"Y": 0.943803,
"RestartSolver": false
},
{
"X": 1.25,
"Y": 0.9796414,
"RestartSolver": false
},
{
"X": 1.333333,
"Y": 0.992799,
"RestartSolver": false
},
{
"X": 1.416667,
"Y": 0.9974749,
"RestartSolver": false
},
{
"X": 1.5,
"Y": 0.9991173,
"RestartSolver": false
},
{
"X": 1.583333,
"Y": 0.9996917,
"RestartSolver": false
},
{
"X": 1.666667,
"Y": 0.9998924,
"RestartSolver": false
},
{
"X": 1.75,
"Y": 0.9999624,
"RestartSolver": false
},
{
"X": 1.833333,
"Y": 0.9999869,
"RestartSolver": false
},
{
"X": 3.333333,
"Y": 1.0,
"RestartSolver": false
}
]
}
}
},
{
"Type": "OtherProtein",
"Species": "Human",
"Molecule": "ATP1A2",
"Category": "European (Pgp modified)",
"Parameters": [
{
"Path": "ATP1A2|Reference concentration",
"Value": 0.39140774,
"Unit": "µmol/l",
"ValueOrigin": {
"Source": "ParameterIdentification",
"Description": "Due to OSP v9 -> v10 switch reported value of 0.48 was recalculated to 0.39"
}
},
{
"Path": "ATP1A2|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "ATP1A2|t1/2 (liver)",
"Value": 36.0,
"Unit": "h"
},
{
"Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
"Value": 0.0062154033171
},
{
"Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
"Value": 0.0508741242
},
{
"Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
"Value": 0.3179118843
},
{
"Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
"Value": 0.0158938619
},
{
"Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
"Value": 0.0786998764
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
"Value": 0.0786998764
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
"Value": 0.0786998764
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
"Value": 0.0786998764
},
{
"Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
"Value": 0.0786998764
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
"Value": 0.0223784807
},
{
"Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
"Value": 0.0223784807
},
{
"Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
"Value": 0.0272345453
},
{
"Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
"Value": 0.7034193524
},
{
"Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
"Value": 0.0073903254795
},
{
"Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
"Value": 0.0389467988
},
{
"Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
"Value": 0.0501579923
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
"Value": 0.0501579923
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
"Value": 0.0501579923
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
"Value": 0.0501579923
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
"Value": 0.0501579923
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
"Value": 0.0501579923
},
{
"Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
"Value": 0.0103243118
},
{
"Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
"Value": 0.0309435884
}
],
"Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
}
],
"Individuals": [
{
"Name": "European (Pgp modified)",
"Seed": 264844784,
"OriginData": {
"CalculationMethods": [
"SurfaceAreaPlsInt_VAR1",
"Body surface area - Mosteller"
],
"Species": "Human",
"Population": "European_ICRP_2002",
"Gender": "MALE",
"Age": {
"Value": 30.0,
"Unit": "year(s)"
}
},
"Parameters": [
{
"Path": "Organism|Liver|EHC continuous fraction",
"Value": 1.0,
"ValueOrigin": {
"Source": "Other",
"Description": "Assumption"
}
}
],
"ExpressionProfiles": [
"P-gp|Human|European (Pgp modified)",
"ATP1A2|Human|European (Pgp modified)"
]
}
],
"Compounds": [
{
"Name": "Digoxin",
"IsSmallMolecule": true,
"PlasmaProteinBindingPartner": "Albumin",
"Lipophilicity": [
{
"Name": "fitted",
"Parameters": [
{
"Name": "Lipophilicity",
"Value": 1.40017663,
"Unit": "Log Units",
"ValueOrigin": {
"Source": "ParameterIdentification",
"Method": "ParameterIdentification"
}
}
]
}
],
"FractionUnbound": [
{
"Name": "Neuhoff (2013)",
"Species": "Human",
"Parameters": [
{
"Name": "Fraction unbound (plasma, reference value)",
"Value": 0.71,
"ValueOrigin": {
"Source": "Publication",
"Method": "InVitro",
"Description": "Neuhoff 2013"
}
}
]
}
],
"Solubility": [
{
"Name": "Aqueous Solubility",
"Parameters": [
{
"Name": "Solubility at reference pH",
"Value": 64.8,
"Unit": "mg/l",
"ValueOrigin": {
"Source": "Internet",
"Method": "InVitro",
"Description": "Drugbank"
}
},
{
"Name": "Reference pH",
"Value": 7.0,
"ValueOrigin": {
"Source": "Internet",
"Method": "InVitro",
"Description": "Drugbank"
}
}
]
}
],
"IntestinalPermeability": [
{
"Name": "fitted",
"Parameters": [
{
"Name": "Specific intestinal permeability (transcellular)",
"Value": 2.7627E-07,
"Unit": "dm/min"
}
]
}
],
"Permeability": [
{
"Name": "fitted",
"Parameters": [
{
"Name": "Permeability",
"Value": 1.0115E-05,
"Unit": "dm/min"
}
]
}
],
"Processes": [
{
"InternalName": "SpecificBinding",
"DataSource": "Katz (2010)",
"Molecule": "ATP1A2",
"Parameters": [
{
"Name": "koff",
"Value": 0.00098888,
"Unit": "1/min",
"ValueOrigin": {
"Source": "Publication",
"Method": "InVitro",
"Description": "Katz 2010"
}
},
{
"Name": "Kd",
"Value": 25.6,
"Unit": "nmol/l",
"ValueOrigin": {
"Source": "ParameterIdentification"
}
}
]
},
{
"InternalName": "LiverClearance",
"DataSource": "Fitted",
"Species": "Human",
"Parameters": [
{
"Name": "Fraction unbound (experiment)",
"Value": 0.71
},
{
"Name": "Lipophilicity (experiment)",
"Value": 1.40017663,
"Unit": "Log Units"
},
{
"Name": "Plasma clearance",
"Value": 0.0,
"Unit": "ml/min/kg"
},
{
"Name": "Specific clearance",
"Value": 0.03758077,
"Unit": "1/min",
"ValueOrigin": {
"Source": "ParameterIdentification"
}
}
]
},
{
"InternalName": "ActiveTransportSpecific_MM",
"DataSource": "Stephens (2001)",
"Molecule": "P-gp",
"Parameters": [
{
"Name": "Transporter concentration",
"Value": 1.0,
"Unit": "µmol/l"
},
{
"Name": "Vmax",
"Value": 8.67,
"Unit": "µmol/l/min"
},
{
"Name": "Km",
"Value": 177.0,
"Unit": "µmol/l"
},
{
"Name": "kcat",
"Value": 71.163,
"Unit": "1/min",
"ValueOrigin": {
"Source": "ParameterIdentification"
}
}
],
"Description": "A transporter mediated unidirectional transfer of a compound across a cellular membrane is described as saturable process following Michaelis-Menten type kinetics. The corresponding kcat value is calculated from a specific Vmax as input value."
},
{
"InternalName": "GlomerularFiltration",
"DataSource": "Steiness (1982)",
"Species": "Human",
"Parameters": [
{
"Name": "GFR fraction",
"Value": 1.0,
"ValueOrigin": {
"Source": "Publication",
"Description": "Steiness (1982)"
}
}
]
}
],
"CalculationMethods": [
"Cellular partition coefficient method - Rodgers and Rowland",
"Cellular permeability - PK-Sim Standard"
],
"Parameters": [
{
"Name": "Molecular weight",
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0.0003095238,
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0.000547618954,
0.0005714562,
0.0005356864,
0.0004404758,
0.0004047903,
0.000190476188,
0.0001071149
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0.4054358,
1.548939,
2.180565,
2.181548,
1.896844,
1.659732,
1.315476,
0.948422134,
0.6309804
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0.0001910448,
0.0006447765,
0.0005253735,
0.00045373122,
0.000441790617,
0.0003223881,
0.0003701488,
0.000238806009,
0.0001313432
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0.2746269,
1.265672,
1.707463,
1.802985,
1.659701,
1.480597,
1.21791,
0.8955224,
0.5850746
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"ObservedDataClassifications": [
{
"Name": "PO",
"Classifications": [
{
"Name": "1 mg",
"Classifiables": [
"Greiner 1999 - po Control (Perpetrator Placebo) - Digoxin - PO - 1 mg - Plasma - agg. (n=8)",
"Hawyard 1978 - 1mg po - Digoxin - PO - 1 mg - Plasma - agg. (n=5)",
"Oosterhuis 1991 - 1mg po - Digoxin - PO - 1 mg - Plasma - agg. (n=10)"
]
},
{
"Name": "0,25 / 0,5 mg",
"Classifiables": [
"Sanofi-Aventis 2009 - 0.25mg md QD - Digoxin - PO - 0,25 / 0,5 mg - Plasma - agg. (n=20)"
]
},
{
"Name": "0.25 mg",
"Classifiables": [
"Eckermann 2012 - 0.25mg po - Digoxin - PO - 250 µg - Plasma - agg. (n=16)",
"Friedrich 2011 - 0.25mg po md - Digoxin - PO - 0.25 mg - Plasma - agg. (n=20)",
"Johne 1999 - 0.25mg po md with placebo day 6 - Digoxin - PO - 0.25 mg - Plasma - agg. (n=12)",
"Johne 1999 - 0.25mg po md with placebo day 15 - Digoxin - PO - 0.25 mg - Plasma - agg. (n=12)",
"Kirch 1986 - 2x0.25mg po md - Digoxin - PO - 0.25 mg - Plasma - agg. (n=7)",
"Rodin 1988 - 2x0.25mg po md - Digoxin - PO - 0.25 mg - Plasma - agg. (n=10)",
"Rodin 1988 - 2x0.25mg po md - Digoxin - PO - 0.25 mg - Plasma - agg. (n=9)",
"Vaidyanathan 2008 - 0.25mg po pd - Digoxin - PO - 0.25 mg - Plasma - agg. (n=22)",
"Wiebe 2020 - Control digoxin - plasma - Digoxin - PO - 0.25 mg - Plasma - agg. (n=12)",
"Wiebe 2020 - Control digoxin - urine - Digoxin - PO - 0.25 mg - Urine - agg. (n=12)",
"Wiebe 2020 - DDI digoxin + verapamil - plasma - Digoxin - PO - 0.25 mg - Plasma - agg. (n=12)",
"Wiebe 2020 - DDI digoxin + verapamil - urine - Digoxin - PO - 0.25 mg - Urine - agg. (n=12)",
"Klein et al. 1982 - Digoxin and Verapamil in MD setting - Digoxin - PO - 0.25 mg - Serum - agg. (n=7)",
"Wiebe 2020 - Digoxin (Cocktail) + Rifampin - Digoxin - PO - 0.25 mg - Plasma - agg. (n=12)",
"Wiebe 2020 - Digoxin (Cocktail) + Rifampin - Digoxin - PO - 0.25 mg - Urine - agg. (n=12)",
"Wiebe 2020 - Digoxin + Placebo - Digoxin - PO - 0.25 mg - Plasma - agg. (n=12)",
"Wiebe 2020 - Digoxin + Placebo - Digoxin - PO - 0.25 mg - Urine - agg. (n=12)",
"Kurata 2002 - G/G2677C/C3435_Digoxin day 16 + Clarithromycin - Digoxin - PO - 0.25 mg - serum - agg. (n=5)",
"Kurata 2002 - T/T2677T/T3435_Digoxin day 16 + Clarithromycin - Digoxin - PO - 0.25 mg - serum - agg. (n=5)",
"Kurata 2002 - G/T2677C/T3435_Digoxin day 16 + Clarithromycin - Digoxin - PO - 0.25 mg - serum - agg. (n=5)",
"Partanen 1995 - Digoxin + Itraconazol in Part 1 - Digoxin - PO - 0.25 mg - serum - agg. (n=10)",
"Partanen 1995 - Digoxin + Itraconazol in Part 2 - Digoxin - PO - 0.25 mg - serum - agg. (n=10)",
"Gurley 2008b - Digoxin without Hyperforin - Digoxin - PO - 0.25 mg - Serum - agg. (n=18)",
"Gurley 2008b - Digoxin with Hyperforin - Digoxin - PO - 0.25 mg - Serum - agg. (n=18)",
"Johne 1999 - Digoxin MD with placebo - Digoxin - PO - 0.25 mg - Plasma - agg. (n=12)",
"Johne 1999 - Digoxin after SD St John's Wort - Digoxin - PO - 0.25 mg - Plasma - agg. (n=13)",
"Johne 1999 - Digoxin after MD St John's Wort - Digoxin - PO - 0.25 mg - Plasma - agg. (n=13)",
"Rodin 1988 - 2x0.25mg po md - Digoxin - PO - 0.25 mg - Urine - agg. (n=10)",
"Rodin 1988 - 2x0.25mg po md with verapamil - Digoxin - PO - 0.25 mg - Urine - agg. (n=10)",
"Rodin 1988 - 2x0.25mg po md - Digoxin - PO - 0.25 mg - Urine - agg. (n=9)",
"Rodin 1988 - 2x0.25mg po md with isradipine - Digoxin - PO - 0.25 mg - Urine - agg. (n=9)",
"Gurley 2008b - with Perpetrator (Echinacea) - Digoxin - PO - 0.25 mg - Serum - agg. (n=18)",
"Gurley 2008b - Control to Perpetrator Rifampicin - Digoxin - PO - 0.25 mg - Serum - agg. (n=18)",
"Gurley 2008b - Control to Perpetrator Clarithromycin - Digoxin - PO - 0.25 mg - Serum - agg. (n=18)",
"Gurley 2008b - Control to Perpetrator Echinacea - Digoxin - PO - 0.25 mg - Serum - agg. (n=18)"
]
},
{
"Name": "0.5 mg",
"Classifiables": [
"Jalava 1997 - po Control (Perpetrator Placebo) - Digoxin - PO - 0.5 mg - Serum - agg. (n=10)",
"Jalava 1997 - po Control (Perpetrator Placebo) - Digoxin - PO - 0.5 mg - Urine - agg. (n=10)",
"Kirby 2012 - Study 1 - Staggered Administration Control - Digoxin - PO - 0.5 mg - Plasma - agg. (n=16)",
"Kirby 2012 - Study 2 - Simultaneous Administration Control - Digoxin - PO - 0.5 mg - Plasma - agg. (n=9)",
"Larsen 2007 - Control (Perpetrator Placebo) - Digoxin - PO - 0.5 mg - Serum - typical (n=10)",
"Reitman 2011 - Week 4 after Perpetrator (Rifampicin) - Digoxin - PO - 0.5 mg - Plasma - agg. (n=11)",
"Verstuyft 2003 - 0.5mg with Placebo - Digoxin - PO - 0.5 mg - Plasma - agg. (n=12)",
"Verstuyft 2003 - 0.5mg with placebo - Digoxin - PO - 0.5 mg - Urine - agg. (n=12)",
"Wagner 1981 - 0.5mg po - Digoxin - PO - 0.5 mg - Urine - agg. (n=6)",
"Wagner 1981 - 0.5mg po - Digoxin - PO - 0.5 mg - Plasma - agg. (n=6)",
"Becquemont 2001 - 0.5mg po - Digoxin - PO - 0.5 mg - Plasma - agg. (n=12)",
"Ragueneau 1999 - 0.5mg po with placebo - Digoxin - PO - 0.5 mg - Plasma - agg. (n=18)",
"Tayrouz 2003 - 0.5mg po with placebo - Digoxin - PO - 0.5 mg - Plasma - agg. (n=12)",
"Westphal 2000 - 0.5mg po - Digoxin - PO - 0.5 mg - Plasma - agg. (n=10)",
"Verstuyft 2003 - 0.5mg with dipyridamole - Digoxin - PO - 0.5 mg - Urine - agg. (n=12)",
"Kurata 2002 - G/G2677C/C3435_Digoxin day 1 - Digoxin - PO - 0.5 mg - Serum - agg. (n=5)",
"Kurata 2002 - T/T2677T/T3435_Digoxin day 1 - Digoxin - PO - 0.5 mg - serum - agg. (n=5)",
"Kurata 2002 - G/T2677C/T3435_Digoxin day 1 - Digoxin - PO - 0.5 mg - serum - agg. (n=5)",
"Gurley 2007 - Digoxin + Rifampicin - Digoxin - PO - 0.5 mg - serum - agg. (n=20)",
"Gurley 2007 - Digoxin + Clarithromycin - Digoxin - PO - 0.5 mg - serum - agg. (n=20)",
"Gurley 2007 - control to Rifampicin - Digoxin - PO - 0.5 mg - serum - agg. (n=20)",
"Gurley 2007 - control to Clarithromycin - Digoxin - PO - 0.5 mg - serum - agg. (n=20)"
]
},
{
"Name": "0.75 mg",
"Classifiables": [
"Rengelshausen 2003 - 0.75mg/kg po with placebo - Digoxin - PO - 0.75 mg - Plasma - agg. (n=12)"
]
},
{
"Name": "0.6 mg",
"Classifiables": [
"Martin 1997 - 0.6mg po - Digoxin - PO - 0.6 mg - Plasma - agg. (n=12)"
]
},
{
"Name": "0.125 mg",
"Classifiables": [
"Qiu 2010 - 0.125mg md QD placebo - Digoxin - PO - 0.125 mg - Plasma - agg. (n=12)",
"Belz et al. 1983 - Digoxin + 80mg Verapamil - Digoxin - PO - 0.125 mg - Plasma - agg. (n=12)",
"Belz et al. 1983 - Digoxin + 120mg Verapamil - Digoxin - PO - 0.125 mg - Plasma - agg. (n=12)",
"Doering et al. 1983 - Digoxin control - Digoxin - PO - 0.125 mg - Serum - agg. (n=9)",
"Doering et al. 1983 - Digoxin+ 80mg Verapamil - Digoxin - PO - 0.125 mg - Serum - agg. (n=9)",
"Belz 1981 - Digoxin + Placebo - Digoxin - PO - 0.125 mg - Plasma - agg. (n=12)",
"Belz 1981 - Digoxin + Verapamil - Digoxin - PO - 0.125 mg - Plasma - agg. (n=12)",
"Belz et al. 1983 - Digoxin control to 80mg Verapamil - Digoxin - PO - 0.125 mg - Plasma - agg. (n=12)",
"Belz et al. 1983 - Digoxin control to 120mg Verapamil - Digoxin - PO - 0.125 mg - Plasma - agg. (n=12)"
]
},
{
"Name": "1/0.0625/0.125 mg",
"Classifiables": [
"Pedersen et al. 1982 - Digoxin and Verapamil in MD setting - Digoxin - PO - 1/0.0625/0.125 mg - Plasma - agg. (n=7)"
]
},
{
"Name": "0.46 mg",
"Classifiables": [
"Schwartz et al. 1982 - Digoxin and Verapamil in MD setting - Digoxin - PO - 0.46 mg - Serum - agg. (n=10)"
]
},
{
"Name": "0.4 mg",
"Classifiables": [
"Gurley 2006 - day 7 plasma + Rifampin - Digoxin - PO - 0.4 mg - serum - agg. (n=16)",
"Gurley 2006 - day 7 plasma + Clarithromycin - Digoxin - PO - 0.4 mg - serum - agg. (n=16)",
"Gurley 2006 - day 1 plasma before Rifampicin - Digoxin - PO - 0.4 mg - serum - agg. (n=16)",
"Gurley 2006 - day 1 plasma before Clarithromycin - Digoxin - PO - 0.4 mg - serum - agg. (n=16)"
]
},
{
"Name": "0.75 (day 1 and 2); 0.25 days 3 (sampling day) mg",
"Classifiables": [
"Arold 2005 - Study B - Digoxin without Hyperforin (Day 1) - Digoxin - PO - 0.75 (day 1 and 2); 0.25 days 3 (sampling day) mg - Plasma - agg. (n=28)"
]
},
{
"Name": "0.75 (day 1 and 2); 0.25 days 3 to 13 mg",
"Classifiables": [
"Arold 2005 - Study B - Digoxin with Hyperforin - Digoxin - PO - 0.75 (day 1 and 2); 0.25 days 3 to 13 mg - Plasma - agg. (n=16)",
"Arold 2005 - Study B - Digoxin with Placebo - Digoxin - PO - 0.75 (day 1 and 2); 0.25 days 3 to 13 mg - Plasma - agg. (n=12)"
]
},
{
"Name": "unknown, see comment ",
"Classifiables": [
"Mueller 2004 - study part 1 - Placebo - before - Digoxin - PO - unknown, see comment - Plasma - agg. (n=5)",
"Mueller 2004 - study part 1 - Placebo - after - Digoxin - PO - unknown, see comment - Plasma - agg. (n=5)",
"Mueller 2004 - study part 1 - LI160 (~28.9mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=6)",
"Mueller 2004 - study part 1 - LI160 (~28.9mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=6)",
"Mueller 2004 - study part 1 - Hypericum powder type A, 4 g/d (~21.1mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=5)",
"Mueller 2004 - study part 1 - Hypericum powder type A, 4 g/d (~21.1mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=5)",
"Mueller 2004 - study part 1 - Hypericum powder type A, 2 g/d (~10.6mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=6)",
"Mueller 2004 - study part 1 - Hypericum powder type A, 2 g/d (~10.6mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=6)",
"Mueller 2004 - study part 2 - Placebo - before - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - study part 2 - Placebo - after - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Hypericum powder type A, 1 g/d (~5.3mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Hypericum powder type A, 1 g/d (~5.3mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Hypericum powder type A, 0.5 g/d (~2.6mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Hypericum powder type A, 0.5 g/d (~2.6mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Hypericum oil extract (~0.13mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Hypericum oil extract (~0.13mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Tea (~0.04mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - Tea (~0.04mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - study part 3 - Placebo - before - Digoxin - PO - unknown, see comment - Plasma - agg. (n=9)",
"Mueller 2004 - study part 3 - Placebo - after - Digoxin - PO - unknown, see comment - Plasma - agg. (n=9)",
"Mueller 2004 - Hypericum powder type B, 2 g/d (~0.3mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=10)",
"Mueller 2004 - Hypericum powder type B, 2 g/d (~0.3mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=10)",
"Mueller 2004 - Fresh plant juice (~3.56mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=10)",
"Mueller 2004 - Fresh plant juice (~3.56mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=10)",
"Mueller 2004 - ZE 117 (~ca-0.38mg/d hyperforin) - without hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)",
"Mueller 2004 - ZE 117 (~ca-0.38mg/d hyperforin) - with hyperforin - Digoxin - PO - unknown, see comment - Plasma - agg. (n=7)"
]
}
]
},
{
"Name": "IV",
"Classifications": [
{
"Name": "0.5 mg",
"Classifiables": [
"Ochs 1975 - 0.5mg Patient 1 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Ochs 1978 - 0.5mg - Digoxin - IV - 0.5 mg - Plasma - agg. (n=9)",
"Wagner 1981 - 0.5mg iv 1h - Digoxin - IV - 0.5 mg - Urine - agg. (n=6)",
"Wagner 1981 - 0.5mg iv 3h - Digoxin - IV - 0.5 mg - Urine - agg. (n=6)",
"Wagner 1981 - 0.5mg iv bolus - Digoxin - IV - 0.5 mg - Urine - agg. (n=6)",
"Wagner 1981 - 0.5mg iv 1h - Digoxin - IV - 0.5 mg - Plasma - agg. (n=6)",
"Wagner 1981 - 0.5mg iv 3h - Digoxin - IV - 0.5 mg - Plasma - agg. (n=6)",
"Wagner 1981 - 0.5mg iv bolus - Digoxin - IV - 0.5 mg - Plasma - agg. (n=6)",
"Ding 2004 - 0.5mg iv placebo - Digoxin - IV - 0.5 mg - Plasma - agg. (n=12)",
"Tsutsumi 2002 - 0.5mg iv - Digoxin - IV - 0.5 mg - Plasma - agg. (n=9)",
"Tsutsumi 2002 - 0.5mg iv with erythromycin - Digoxin - IV - 0.5 mg - Plasma - agg. (n=9)",
"Tsutsumi 2002 - 0.5mg iv with clarithromycin - Digoxin - IV - 0.5 mg - Plasma - agg. (n=9)",
"Tsutsumi 2002 - 0.5mg iv - Digoxin - IV - 0.5 mg - Urine - agg. (n=9)",
"Tsutsumi 2002 - 0.5mg iv with erythromycin - Digoxin - IV - 0.5 mg - Urine - agg. (n=9)",
"Tsutsumi 2002 - 0.5mg iv with clarithromycin - Digoxin - IV - 0.5 mg - Urine - agg. (n=9)",
"Ochs 1975 - 0.5mg Patients with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Urine - agg. (n=8)",
"Ochs 1978 - 0.5mg - Digoxin - IV - 0.5 mg - Urine - agg. (n=9)",
"Ochs 1975 - 0.5mg Patient 2 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Ochs 1975 - 0.5mg Patient 3 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Ochs 1975 - 0.5mg Patient 4 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Ochs 1975 - 0.5mg Patient 5 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Ochs 1975 - 0.5mg Patient 6 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Ochs 1975 - 0.5mg Patient 7 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Ochs 1975 - 0.5mg Patient 8 with normal colon mucosa - Digoxin - Intracolonic - 0.5 mg - Plasma - indiv.",
"Kurata 2002 - G/G2677C/C3435_Digoxin day 1 - Digoxin - IV - 0.5 mg - serum - agg. (n=5)",
"Kurata 2002 - T/T2677T/T3435_Digoxin day 1 - Digoxin - IV - 0.5 mg - serum - agg. (n=5)",
"Kurata 2002 - G/T2677C/T3435_Digoxin day 1 - Digoxin - IV - 0.5 mg - serum - agg. (n=5)"
]
},
{
"Name": "1 mg",
"Classifiables": [
"Greiner 1999 - iv Control (Perpetrator Placebo) - Digoxin - IV - 1 mg - Plasma - agg. (n=8)",
"Kramer 1979 - 1mg iv bolus - Digoxin - IV - 1 mg - Plasma - agg. (n=12)",
"Ochs 1978 - 1mg - Digoxin - IV - 1 mg - Plasma - agg. (n=9)",
"Ochs 1978 - 1mg - Digoxin - IV - 1 mg - Urine - agg. (n=9)",
"Johnson et al. 1987 - Digoxin IV control - Digoxin - IV - 1 mg - Serum - agg. (n=12)",
"Johnson et al. 1987 - Digoxin IV control - Digoxin - IV - 1 mg - Urine - agg. (n=12)",
"Johnson et al. 1987 - Digoxin IV + Verapamil - Digoxin - IV - 1 mg - Serum - agg. (n=12)",
"Johnson et al. 1987 - Digoxin IV + Verapamil - Digoxin - IV - 1 mg - Urine - agg. (n=12)",
"Pedersen et al. 1983 - Digoxin IV control - Digoxin - IV - 1 mg - Plasma - indiv.",
"Pedersen et al. 1983 - Digoxin IV + Verapamil - Digoxin - IV - 1 mg - Plasma - indiv.",
"Pedersen 1981 - Digoxin without Verapamil - Digoxin - IV - 1 mg - Urine - agg. (n=7)"
]
},
{
"Name": "0.75 mg",
"Classifiables": [
"Koup 1975 - 0.75mg iv h - Digoxin - IV - 0.75 mg - Plasma - indiv.",
"Pedersen 1981 - Digoxin withVerapamil - Digoxin - IV - 0.75 mg - Urine - agg. (n=7)"
]
},
{
"Name": "0.01 mg/kg",
"Classifiables": [
"Lalonde 1985 - 0.01mg/kg iv control - Digoxin - IV - 10 (250 µg/ml) µg/kg - Plasma - agg. (n=11)",
"Lalonde 1985 - 0.01mg/kg charcoal - Digoxin - IV - 10 (250 µg/ml) µg/kg - Plasma - agg. (n=11)",
"Rengelshausen 2003 - 0.01mg/kg iv with placebo - Digoxin - IV - 0.01 mg/kg - Plasma - agg. (n=3)"
]
},
{
"Name": "1.5 mg",
"Classifiables": [
"Ochs 1978 - 1.5mg - Digoxin - IV - 1.5 mg - Plasma - agg. (n=9)",
"Ochs 1978 - 1.5mg - Digoxin - IV - 1.5 mg - Urine - agg. (n=9)"
]
},
{
"Name": "0.25 mg",
"Classifiables": [
"Kurata 2002 - G/G2677C/C3435_Digoxin day 16 + Clarithromycin - Digoxin - IV - 0.25 mg - serum - agg. (n=5)",
"Kurata 2002 - T/T2677T/T3435_Digoxin day 16 + Clarithromycin - Digoxin - IV - 0.25 mg - serum - agg. (n=5)",
"Kurata 2002 - G/T2677C/T3435_Digoxin day 16 + Clarithromycin - Digoxin - IV - 0.25 mg - serum - agg. (n=5)"
]
}
]
}
],
"SimulationClassifications": [
{
"Name": "Digoxin",
"Classifications": [
{
"Name": "Digoxin colonic admin.",
"Classifiables": [
"Digoxin colon, 0.5 mg"
]
},
{
"Name": "Digoxin iv",
"Classifiables": [
"Digoxin iv, 0.01 mg/kg",
"Digoxin iv, 0.01 mg/kg, Charcoal",
"Digoxin iv, 0.5 mg, 1 h",
"Digoxin iv, 0.5 mg, 3 h",
"Digoxin iv, 0.5 mg, Bolus",
"Digoxin iv, 0.75 mg, 1h",
"Digoxin iv, 1.0 mg, 0.5 h",
"Digoxin iv, 1.0 mg, 1 h",
"Digoxin iv, 1.0 mg, Bolus",
"Digoxin iv, 1.5 mg, 1 h"
]
},
{
"Name": "Digoxin po",
"Classifiables": [
"Digoxin po, 0.25 mg",
"Digoxin po, 0.5 mg",
"Digoxin po, 0.6 mg",
"Digoxin po, 0.75 mg",
"Digoxin po, 1.0 mg",
"Digoxin po, 0.4 mg"
]
},
{
"Name": "Digoxin po, MD",
"Classifiables": [
"Digoxin po MD, 0.125 mg",
"Digoxin po MD, 0.25 mg",
"Digoxin po MD, 0.25 mg, LD",
"Digoxin po MD, 2x 0.25 mg",
"Digoxin po MD, 2x 0.25 mg - 2"
]
}
]
}
]
}