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(n=28)", "Huang 2013 - EFV administration alone - Efavirenz - PO - 600 mg - Plasma - agg. (n=12)", "Mouly 2002 - 200 mg, Day 1 - Efavirenz - PO - 200 mg - Plasma - agg. (n=8)", "Mouly 2002 - 400 mg, Day 1 - Efavirenz - PO - 400 mg - Plasma - agg. (n=8)", "Mouly 2002 - 200 mg, Day 10 - Efavirenz - PO - 200 mg - Plasma - agg. (n=8)", "Mouly 2002 - 400 mg, Day 10 - Efavirenz - PO - 400 mg - Plasma - agg. (n=8)", "Damle 2008 - Efavirenz alone - Efavirenz - PO - 600 mg - Plasma - agg. (n=16)", "Liu 2008 - Group 1, efavirenz alone - Efavirenz - PO - 400 mg - Plasma - agg. (n=16)", "Liu 2008 - Group 2, efavirenz alone - Efavirenz - PO - 400 mg - Plasma - agg. (n=11)", "Liu 2008 - Group 2, efavirenz + placebo - Efavirenz - PO - 400 mg - Plasma - agg. (n=11)", "Malvestutto 2014 - Efavirenz alone - Efavirenz - PO - 600 mg - Plasma - agg. (n=14)", "Soon 2010 - Efavirenz alone - Efavirenz - PO - 600 mg - Plasma - agg. (n=12)" ] }, { "Name": "DDI", "Classifiables": [ "Kharasch 2012 - Day 1 - Efavirenz - PO - 600 mg - Plasma - agg. (n=12)", "Kharasch 2012 - Day 14 - Efavirenz - PO - 600 mg - Plasma - agg. (n=12)", "Kharasch 2012 - Alfenatil PO alone - Alfentanil - PO - 43 µg/kg - Plasma - agg. (n=12)", "Kharasch 2012 - Alfenatil PO + efavirenz - Alfentanil - PO - 43 µg/kg - Plasma - agg. (n=12)", "Kharasch 2012 - Alfenatil IV alone - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "Kharasch 2012 - Alfenatil IV + efavirenz - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "Katzenmaier 2010 - Midazolam + Efavirenz - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "Katzenmaier 2010 - Midazolam control - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "Mikus 2017 - Efavirenz + Midazolam PO day 1 - Midazolam - PO - 4 mg - Plasma - agg. (n=12)", "Mikus 2017 - Efavirenz + Midazolam IV day 1 - Midazolam - IV - 2 mg - Plasma - agg. (n=12)", "Mikus 2017 - Midazolam control PO - Midazolam - PO - 4 mg - Plasma - agg. (n=12)", "Mikus 2017 - Midazolam control IV - Midazolam - IV - 2 mg - Plasma - agg. (n=12)", "Mikus 2017 - Midazolam + Efavirenz - Efavirenz - PO - 400 mg - Plasma - agg. (n=12)" ] } ], "SimulationClassifications": [ { "Name": "Single dose", "Classifiables": [ "Xu 2013, 600mg SD EM", "Xu 2013, 600mg SD IM", "Xu 2013, 600mg SD PM", "Ogburn 2010, 600mg SD" ] }, { "Name": "Multiple dose", "Classifiables": [ "Mouly 2002, 200mg MD", "Mouly 2002, 400mg MD", "Dooley 2012, 600mg MD EM", "Dooley 2012, 600mg MD IM", "Dooley 2012, 600mg MD PM", "Garg 2013, 600mg MD", "Huang 2012, 600mg MD", "Liu 2008, 400 mg PO OD", "Malvestutto 2014, 600mg PO OD", "Damle 2008, 600 mg PO OD", "Soon 2010, 600mg MD over 28 days" ] }, { "Name": "DDI", "Classifiables": [ "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD", "Katzenmaier 2010, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Mikus 2017, Midazolam alone" ] } ] }