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(n=24)", "Austin 1980 - 125 mg over 15 min (Regimen 2) - Erythromycin - IV - 125 mg - Urine - agg. (n=5)", "Austin 1980 - 250 mg over 15 min (Regimen 2) - Erythromycin - IV - 250 mg - Urine - agg. (n=5)", "Austin 1980 - 500 mg over 15 min (Regimen 2) - Erythromycin - IV - 500 mg - Urine - agg. (n=4)", "Austin 1980 - 900 mg over 15 min (Regimen 2) - Erythromycin - IV - 900 mg - Urine - agg. (n=3)" ] }, { "Name": "Barre 1987", "Classifiables": [ "Barre 1987 - 500 mg over 30 min, total concentrations - Erythromycin - IV - 500 mg - Serum - agg. (n=6)", "Barre 1987 - 500 mg over 30 min, unbound concentrations - Erythromycin - IV - 500 mg - Serum - agg. (n=6)", "Barre 1987 - 500 mg over 30 min, total concentrations - Erythromycin - IV - 500 mg - Urine - agg. (n=6)" ] }, { "Name": "Huppertz 2011", "Classifiables": [ "Huppertz 2011 - Treatment group, erythromycin - Erythromycin - IV - 1000 mg - Plasma - agg. (n=12)" ] }, { "Name": "Pasic 1987", "Classifiables": [ "Pasic 1987 - Without oral theophylline co-administration - Erythromycin - IV - 300 mg - Serum - agg. (n=8)", "Pasic 1987 - Without oral theophylline co-administration - Erythromycin - IV - 300 mg - Urine - agg. (n=8)" ] }, { "Name": "Sun 2010", "Classifiables": [ "Sun 2010 - Subjects with normal renal function - Erythromycin - IV - 125 mg - Plasma - agg. (n=12)", "Sun 2010 - Subjects with normal renal function - Erythromycin - IV - 125 mg - Urine - agg. (n=12)" ] }, { "Name": "Simon 1980", "Classifiables": [ "Simon 1980 - 500 mg IV - Erythromycin - IV - 500 mg - Serum - agg. (n=6)" ] } ] }, { "Name": "PO", "Classifications": [ { "Name": "Kivistö 1997", "Classifiables": [ "Kivistö 1997 - with Perpetrator (Erythromycin) - Erythromycin - PO - 500 mg - Plasma - agg. (n=8)" ] }, { "Name": "Birkett 1990", "Classifiables": [ "Birkett 1990 - 250 mg erythromycin, single dose - Erythromycin - PO - 250 mg - Plasma - agg. (n=12)", "Birkett 1990 - 250 mg erythromycin, multiple dose - Erythromycin - PO - 250 mg - Plasma - agg. (n=12)" ] }, { "Name": "DiSanto 1981", "Classifiables": [ "DiSanto 1981 - Overnight fast, enteric-coated erythromycin tablets (study 1) - Erythromycin - PO - 500 mg - Serum - agg. (n=21)", "DiSanto 1981 - 2h fast, enteric-coated erythromycin tablets (study 2) - Erythromycin - PO - 500 mg - Serum - agg. (n=12)" ] }, { "Name": "Iliopoulou 1982", "Classifiables": [ "Iliopoulou 1982 - fourth day, before theophylline administration - Erythromycin - PO - 500 mg - Serum - agg. (n=6)" ] }, { "Name": "Josefsson 1982a", "Classifiables": [ "Josefsson 1982a - erythromycin base 250 mg - Erythromycin - PO - 250 mg - Serum - agg. (n=23)", "Josefsson 1982a - erythromycin base 500 mg - Erythromycin - PO - 500 mg - Serum - agg. (n=23)", "Josefsson 1982a - erythromycin base 1000 mg - Erythromycin - PO - 1000 mg - Serum - agg. (n=23)", "Josefsson 1982a - erythromycin stearate 500 mg (base equivalent) - Erythromycin - PO - 500 mg - Serum - agg. (n=23)" ] }, { "Name": "Kavi 1988", "Classifiables": [ "Kavi 1988 - Serum levels - Erythromycin - PO - 500 mg - Serum - agg. (n=6)" ] }, { "Name": "Kroboth 1982", "Classifiables": [ "Kroboth 1982 - Normal subjects - Erythromycin - PO - 500 mg - Serum - agg. (n=6)" ] }, { "Name": "Malmborg 1978", "Classifiables": [ "Malmborg 1978 - Single dose after overnight fast - Erythromycin - PO - 500 mg - Plasma - agg. (n=15)", "Malmborg 1978 - Single dose before standardized breakfast - Erythromycin - PO - 500 mg - Plasma - agg. (n=15)", "Malmborg 1978 - Day 7, every 8 h - Erythromycin - PO - 500 mg - Plasma - agg. (n=15)" ] }, { "Name": "Miglioli 1990", "Classifiables": [ "Miglioli 1990 - First dose, young subjects - Erythromycin - PO - 1 g - Serum - agg. (n=8)", "Miglioli 1990 - Seventh dose, young subjects - Erythromycin - PO - 1 g - Serum - agg. (n=8)" ] }, { "Name": "Posti 1983", "Classifiables": [ "Posti 1983 - Formulation A1 (film-coated tabet, ery stearate), fasted - Erythromycin - PO - 500 mg - Serum - agg. (n=15)", "Posti 1983 - Formulation E (enteric-coated tablets, ery base), fasted - Erythromycin - PO - 500 mg - Serum - agg. (n=15)", "Posti 1983 - Formulation A2 (film-coated tabet, ery stearate), study 2 - Erythromycin - PO - 500 mg - Serum - agg. (n=12)", "Posti 1983 - Formulation RN (film-coated tabet, ery stearate), study 2 - Erythromycin - PO - 500 mg - Serum - agg. (n=12)" ] }, { "Name": "Schreiner 1984", "Classifiables": [ "Schreiner 1984 - Part I, stearate tablet - Erythromycin - PO - 500 mg - Serum - agg. (n=14)", "Schreiner 1984 - Part I, base (enteric-coated pellets) - Erythromycin - PO - 500 mg - Serum - agg. (n=14)", "Schreiner 1984 - Part II, stearate tablet - Erythromycin - PO - 500 mg - Serum - agg. (n=10)", "Schreiner 1984 - Part II, base (enteric-coated pellets) - Erythromycin - PO - 500 mg - Serum - agg. (n=10)" ] }, { "Name": "Yakatan 1980", "Classifiables": [ "Yakatan 1980 - Stearate, single dose - Erythromycin - PO - 250 mg - Serum - agg. (n=8)", "Yakatan 1980 - Stearate, five doses, every 6 h - Erythromycin - PO - 250 mg - Serum - agg. (n=24)", "Yakatan 1980 - Base, five doses, every 6 h - Erythromycin - PO - 250 mg - Serum - agg. (n=24)" ] }, { "Name": "Shanson 1984", "Classifiables": [ "Shanson 1984 - Erythromycin stearate - Erythromycin - PO - 1500 mg - Serum - agg. (n=11)" ] }, { "Name": "Parsons 1977", "Classifiables": [ "Parsons 1977 - Erythromycin stearate, supine, normal subjects - Erythromycin - PO - 500 mg - Plasma - agg. (n=6)", "Parsons 1977 - Erythromycin stearate, supine, normal subjects - Erythromycin - PO - 500 mg - Urine - agg. (n=6)", "Parsons 1977 - Erythromycin stearate, walking, normal subjects - Erythromycin - PO - 500 mg - Plasma - agg. (n=6)", "Parsons 1977 - Erythromycin stearate, walking, normal subjects - Erythromycin - PO - 500 mg - Urine - agg. (n=6)" ] }, { "Name": "Henry 1980", "Classifiables": [ "Henry 1980 - Erythromycin stearate - Erythromycin - PO - 500 mg - Plasma - agg. (n=6)" ] }, { "Name": "Berend 1979", "Classifiables": [ "Berend 1979 - Erythromycin stearate - Erythromycin - PO - 500 mg - Plasma - agg. (n=10)" ] }, { "Name": "Simon 1980", "Classifiables": [ "Simon 1980 - 500 mg stearate PO - Erythromycin - PO - 500 mg - Serum - agg. (n=10)" ] }, { "Name": "Brannan 1995", "Classifiables": [ "Brannan 1995 - Erythromycin with placebo - Erythromycin - PO - 500 mg - Plasma - agg. (n=8)" ] }, { "Name": "Yakatan 1979", "Classifiables": [ "Yakatan 1979 - Manufacturer Abbott - Erythromycin - PO - 250 mg - Serum - agg. (n=10)", "Yakatan 1979 - Manufacturer Barr - Erythromycin - PO - 250 mg - Serum - agg. (n=10)", "Yakatan 1979 - Manufacturer Bristol - Erythromycin - PO - 250 mg - Serum - agg. (n=10)", "Yakatan 1979 - Manufacturer Mylan - Erythromycin - PO - 250 mg - Serum - agg. (n=10)", "Yakatan 1979 - Manufacturer Purepac - Erythromycin - PO - 250 mg - Serum - agg. (n=10)" ] } ] }, { "Name": "DDI", "Classifications": [ { "Name": "Olkkola1993", "Classifiables": [ "Olkkola 1993 - iv with Perpetrator (Erythromycin) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=6)", "Olkkola 1993 - iv Control (Perpetrator Placebo) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=6)", "Olkkola 1993 - iv with Perpetrator (Erythromycin) - Erythromycin - PO - 500 mg - Plasma - agg. (n=6)", "Olkkola 1993 - iv with Perpetrator, Ind01 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - iv with Perpetrator, Ind02 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - iv with Perpetrator, Ind03 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - iv with Perpetrator, Ind04 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - iv with Perpetrator, Ind05 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - iv with Perpetrator, Ind06 - Erythromycin - PO - 500 mg - Plasma - indiv.", "AUC", "Olkkola 1993 - po Control (Perpetrator Placebo) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "Olkkola 1993 - po with Perpetrator (Erythromycin) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "Olkkola 1993 - po with Perpetrator, Ind01 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind02 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind03 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind04 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind05 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind06 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind07 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind08 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind09 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind10 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind11 - Erythromycin - PO - 500 mg - Plasma - indiv.", "Olkkola 1993 - po with Perpetrator, Ind12 - Erythromycin - PO - 500 mg - Plasma - indiv.", "AUCratio_Olkkola1993.PO", "AUCratio_Olkkola1993.IV" ] } ] } ], "SimulationClassifications": [ { "Name": "IV", "Classifiables": [ "IV_1000mg_Huppertz2011", "IV_125mg_Austin1980", "IV_125mg_Sun2010", "IV_250mg_3min_Austin1980", "IV_250mg_Austin1980", "IV_300mg_Pasic1987", "IV_500mg_Austin1980", "IV_500mg_Barre1987", "IV_500mg_Simon1980", "IV_900mg_Austin1980" ] }, { "Name": "Oral stearate film-coated tablet", "Classifiables": [ "1000mg_Miglioli1990_MD", "1500mg_Shanson1984", "250mg_Yakatan1979", "250mg_Yakatan1980_stearate", "250mg_Yakatan1980_stearate_MD", "500mg_Berend1979_MD", "500mg_Brannan1995_MD", "500mg_Henry1980", "500mg_Iliopoulou1982_MD", "500mg_Josefsson1982a", "500mg_Kavi1988", "500mg_Malmborg1978_MD", "500mg_Parsons1977", "500mg_Posti1983_A1", "500mg_Posti1983_A2/RN", "500mg_Schreiner1984_stearate", "500mg_Simon1980" ] }, { "Name": "Oral base enteric coated tablet", "Classifiables": [ "250mg_Yakatan1980_base_MD", "500mg_DiSanto1981", "500mg_Kroboth1982", "500mg_Posti1982_E" ] }, { "Name": "Oral base enteric coated pellets", "Classifiables": [ "1000mg_Josefsson1982a_pellets", "250mg_Birkett1990_MD", "250mg_Birkett1990_SD", "250mg_Josefsson1982a_pellets", "500mg_Josefsson1982a_pellets", "500mg_Kivistö1997_pellets_MD", "500mg_Schreiner1984_pellets" ] }, { "Name": "DDI", "Classifiables": [ "Control_Olkkola1993_IV", "Control_Olkkola1993_PO", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral" ] } ] }