{
  "Version": 78,
  "Individuals": [
    {
      "Name": "European (P-gp modified, CYP3A4 36 h)",
      "Seed": 17189110,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "GABRG2|Reference concentration",
          "Value": 1.04099689,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "GABRG2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "GABRG2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Bone|Intracellular|P-gp|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|GABRG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Brain|Intracellular|P-gp|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Heart|Intracellular|P-gp|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Lung|Intracellular|P-gp|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        },
        {
          "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "P-gp|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "P-gp|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "P-gp|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A4|Reference concentration",
          "Value": 2.32,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "UGT1A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "P-gp",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        },
        {
          "Name": "UGT1A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "UGT1A4"
          }
        },
        {
          "Name": "GABRG2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    },
    {
      "Name": "Abdel-Rahman 2-6yr European (P-gp modified, CYP3A4 36 h)",
      "Seed": 38922873,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 4.2,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 18.2,
          "Unit": "kg"
        },
        "Height": {
          "Value": 102.2,
          "Unit": "cm"
        },
        "ValueOrigin": {
          "Source": "Publication",
          "Method": "InVivo",
          "Description": "Abdel-Rahman 2007"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ABCB1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ABCB1|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ABCB1|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ABCB1|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ABCB1|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ABCB1|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ABCB1|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ABCB1|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ABCB1|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "ABCB1",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    },
    {
      "Name": "Abdel-Rahman 0.5-2yr European (P-gp modified, CYP3A4 36 h)",
      "Seed": 38992465,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 1.4,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 9.1,
          "Unit": "kg"
        },
        "Height": {
          "Value": 67.8,
          "Unit": "cm"
        },
        "ValueOrigin": {
          "Source": "Publication",
          "Method": "InVivo",
          "Description": "Abdel-Rahman 2007"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ABCB1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ABCB1|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ABCB1|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ABCB1|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ABCB1|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ABCB1|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ABCB1|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ABCB1|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ABCB1|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "ABCB1",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    },
    {
      "Name": "Abdel-Rahman 12-16yr European (P-gp modified, CYP3A4 36 h)",
      "Seed": 39023540,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 14.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 55.1,
          "Unit": "kg"
        },
        "Height": {
          "Value": 151.1,
          "Unit": "cm"
        },
        "ValueOrigin": {
          "Source": "Publication",
          "Method": "InVivo",
          "Description": "Abdel-Rahman 2007"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ABCB1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ABCB1|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ABCB1|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ABCB1|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ABCB1|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ABCB1|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ABCB1|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ABCB1|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ABCB1|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "ABCB1",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    },
    {
      "Name": "Abdel-Rahman 6-12yr European (P-gp modified, CYP3A4 36 h)",
      "Seed": 39053586,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 9.5,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 28.8,
          "Unit": "kg"
        },
        "Height": {
          "Value": 130.4,
          "Unit": "cm"
        },
        "ValueOrigin": {
          "Source": "Publication",
          "Method": "InVivo",
          "Description": "Abdel-Rahman 2007"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ABCB1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ABCB1|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ABCB1|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ABCB1|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ABCB1|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ABCB1|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ABCB1|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ABCB1|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ABCB1|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "ABCB1",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    },
    {
      "Name": "Groll all children European (P-gp modified, CYP3A4 36 h)",
      "Seed": 39141212,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 12.1,
          "Unit": "year(s)"
        },
        "ValueOrigin": {
          "Source": "Publication",
          "Method": "InVivo",
          "Description": "Groll 2002"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ABCB1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ABCB1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ABCB1|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ABCB1|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ABCB1|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ABCB1|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ABCB1|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ABCB1|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ABCB1|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ABCB1|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ABCB1|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "ABCB1",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Itraconazole",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Fit",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 4.624,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Description": "Fit"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Templeton, 2008",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.6016197247,
              "Unit": "%"
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Solution fasted (Taupitz et al. 2013)",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 8.0,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Taupitz et al. 2013"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 6.5,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Taupitz et al. 2013"
              }
            }
          ]
        },
        {
          "Name": "Solution fed",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 1.58,
              "Unit": "mg/l"
            },
            {
              "Name": "Reference pH",
              "Value": 6.5
            }
          ]
        },
        {
          "Name": "Capsule fasted",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 0.9728307177,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Capsule fasted' on 2019-05-15 12:25"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 6.5
            }
          ]
        },
        {
          "Name": "Capsule fed",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 0.7,
              "Unit": "mg/l"
            },
            {
              "Name": "Reference pH",
              "Value": 6.5
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fit",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 5.3261558344E-05,
              "Unit": "dm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Description": "Fit"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 3.7,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "Isoherranen 2004",
          "Molecule": "CYP3A4",
          "Metabolite": "Hydroxy-Itraconazole",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 0.27,
              "Unit": "pmol/min/pmol rec. enzyme",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            },
            {
              "Name": "Km",
              "Value": 2.0688492598,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            },
            {
              "Name": "kcat",
              "Value": 0.0402937875,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Isoherranen, 2004",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 1.3,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Description": "Isoherranen, 2004"
              }
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Shityakov 2014",
          "Molecule": "ABCB1",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 0.008,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Shityakov 2014"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Cl",
          "Value": 2.0
        },
        {
          "Name": "Molecular weight",
          "Value": 705.633,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "Hydroxy-Itraconazole",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Fit",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 3.718,
              "Unit": "Log Units"
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Templeton, 2008",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 1.7,
              "Unit": "%",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Templeton, 2008"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "No value available",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 1.0,
              "Unit": "mg/l"
            },
            {
              "Name": "Reference pH",
              "Value": 7.0
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 3.7,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "Isoherranen 2004",
          "Molecule": "CYP3A4",
          "Metabolite": "Keto-Itraconazole",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 0.543,
              "Unit": "nmol/min/pmol rec. enzyme",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            },
            {
              "Name": "Km",
              "Value": 4.1716224833,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            },
            {
              "Name": "kcat",
              "Value": 0.0203370845,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen, 2004"
              }
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Isoherranen, 2004",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 14.4,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen, 2004"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Cl",
          "Value": 2.0
        },
        {
          "Name": "Molecular weight",
          "Value": 721.633,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "Keto-Itraconazole",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Fit",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 4.2109086248,
              "Unit": "Log Units"
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Templeton, 2008",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 1.0,
              "Unit": "%",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Templeton, 2008"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "No value available",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 1.0,
              "Unit": "mg/l"
            },
            {
              "Name": "Reference pH",
              "Value": 7.0
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 3.7,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "Isoherranen 2004",
          "Molecule": "CYP3A4",
          "Metabolite": "N-desalkyl-Itraconazole",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 0.0869,
              "Unit": "pmol/min/pmol rec. enzyme",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            },
            {
              "Name": "Km",
              "Value": 2.2214874285,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            },
            {
              "Name": "kcat",
              "Value": 0.3933927416,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Isoherranen, 2004",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 5.12,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Cl",
          "Value": 2.0
        },
        {
          "Name": "Molecular weight",
          "Value": 719.617,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "N-desalkyl-Itraconazole",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Fit",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 5.1837535822,
              "Unit": "Log Units"
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Templeton, 2008",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 1.1,
              "Unit": "%",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Templeton, 2008"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "No value available",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 1.0,
              "Unit": "mg/l"
            },
            {
              "Name": "Reference pH",
              "Value": 7.0
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 3.7,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "Isoherranen 2004",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 0.0,
              "Unit": "nmol/min/pmol rec. enzyme"
            },
            {
              "Name": "Km",
              "Value": 0.6284266369,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            },
            {
              "Name": "kcat",
              "Value": 0.0605873508,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen 2004"
              }
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Isoherranen, 2004",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 0.32,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Isoherranen, 2004"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Cl",
          "Value": 2.0
        },
        {
          "Name": "Molecular weight",
          "Value": 649.527,
          "Unit": "g/mol"
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "Capsule fasted",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 406.3001802552,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Capsule fasted' on 2019-05-15 12:25"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 1.4297720052,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Capsule fasted' on 2019-05-15 12:25"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "Capsule fed",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 138.95,
          "Unit": "min"
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.82
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "Solution",
      "FormulationType": "Formulation_Dissolved"
    }
  ],
  "Protocols": [
    {
      "Name": "Abdel-Rahman 2007 2.5mg_kg infusion",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.5,
          "Unit": "mg/kg"
        },
        {
          "Name": "Infusion time",
          "Value": 60.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Barone 1993 200 mg capsules single followed from 72h 200 mg BID 14 days",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 2.82,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 72.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 29.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 3",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 432.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "day(s)"
    },
    {
      "Name": "Barone 1998a Itra 200 mg QD days 0-14",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "day(s)"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 15.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Groll 2002 2.5mg_kg_PO_MD bid",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_12_12",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.5,
          "Unit": "mg/kg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 16.0,
          "Unit": "day(s)",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "Groll 2002 2.5mg_kg_PO_MD qd",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_24",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.5,
          "Unit": "mg/kg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 16.0,
          "Unit": "day(s)",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "Groll 2002 2.5mg_kg_PO_SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.5,
          "Unit": "mg/kg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 16.0,
          "Unit": "day(s)",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "Hardin 1988 100 mg capsule single then 100 mg days 3 to 15",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 100.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 100.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 3.0,
              "Unit": "day(s)",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 13.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 1.0,
              "Unit": "day(s)",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Hardin 1988 200 mg capsules BID day 1 then 200 mg BID days 3.5 to 15",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 2.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 3.5,
              "Unit": "day(s)",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 24.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.5,
              "Unit": "day(s)",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Hardin 1988 200 mg capsules single then 200 mg days 3 to 15",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 3.0,
              "Unit": "day(s)",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 13.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 1.0,
              "Unit": "day(s)",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "IV MD 200 mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 120.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 2.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 8.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 120.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 2.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 8.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 3",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 120.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 48.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 5.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "IV SD 100 mg",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 100.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 60.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Olkkola 1994 Itraconazole 200 mg QD",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 4.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "PO SD 100 mg",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 100.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 1.37,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "PO SD 200 mg",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 200.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Templeton 2008 100 mg po solution 7 days",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_24",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 100.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 7.0,
          "Unit": "day(s)",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "vanPeer 1989 100 mg MD QD",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_24",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 100.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 15.0,
          "Unit": "day(s)",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "PO MD 200 mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 200.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 1.37,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 5.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "PO MD 100 mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 100.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 1.37,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 4.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 100.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 6.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 4.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    }
  ],
  "Events": [
    {
      "Name": "High Fat Breakfast",
      "Template": "Meal: High-fat breakfast (Human)"
    },
    {
      "Name": "Standard Meal",
      "Template": "Meal: Standard (Human)"
    }
  ],
  "Simulations": [
    {
      "Name": "100 mg IV SD",
      "Model": "4Comp",
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  ],
  "ObservedDataClassifications": [
    {
      "Name": "Olkkola 1994",
      "Classifications": [
        {
          "Name": "po with Perpetrator (Itraconazole)",
          "Classifiables": [
            "Olkkola 1994 - po with Perpetrator (Itraconazole) - Itraconazole - PO - 200 mg - Plasma - agg. (n=9)"
          ]
        }
      ]
    },
    {
      "Name": "Barone 1993",
      "Classifications": [
        {
          "Name": "day 1 fasted",
          "Classifiables": [
            "Barone 1993 - day 1 fasted - Itraconazole - PO - 200 mg - Plasma - agg. (n=28)",
            "Barone 1993 - day 1 fasted - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=28)"
          ]
        },
        {
          "Name": "day 1 fed",
          "Classifiables": [
            "Barone 1993 - day 1 fed - Itraconazole - PO - 200 mg - Plasma - agg. (n=28)",
            "Barone 1993 - day 1 fed - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=28)"
          ]
        },
        {
          "Name": "day 15 fed",
          "Classifiables": [
            "Barone 1993 - day 15 fed - Itraconazole - PO - 200 mg - Plasma - agg. (n=28)",
            "Barone 1993 - day 15 fed - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=28)"
          ]
        }
      ]
    },
    {
      "Name": "Hardin 1988",
      "Classifications": [
        {
          "Name": "B 200 mg OD (day 1)",
          "Classifiables": [
            "Hardin 1988 - B 200 mg OD (day 1) - Itraconazole - PO - 200 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "B 200 mg OD (day 7-15)",
          "Classifiables": [
            "Hardin 1988 - B 200 mg OD (day 7-15) - Itraconazole - PO - 200 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "B 200 mg OD (day 15)",
          "Classifiables": [
            "Hardin 1988 - B 200 mg OD (day 15) - Itraconazole - PO - 200 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "C 200 mg BID (day 1)",
          "Classifiables": [
            "Hardin 1988 - C 200 mg BID (day 1) - Itraconazole - PO - 200 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "C 200 mg BID (day 7-15)",
          "Classifiables": [
            "Hardin 1988 - C 200 mg BID (day 7-15) - Itraconazole - PO - 200 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "C 200 mg BID (day 15)",
          "Classifiables": [
            "Hardin 1988 - C 200 mg BID (day 15) - Itraconazole - PO - 200 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "A 100 mg OD (day 1)",
          "Classifiables": [
            "Hardin 1988 - A 100 mg OD (day 1) - Itraconazole - PO - 100 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "A 100 mg OD (day 7-15)",
          "Classifiables": [
            "Hardin 1988 - A 100 mg OD (day 7-15) - Itraconazole - PO - 100 mg - Plasma - agg. (n=5)"
          ]
        },
        {
          "Name": "A 100 mg OD (day 15)",
          "Classifiables": [
            "Hardin 1988 - A 100 mg OD (day 15) - Itraconazole - PO - 100 mg - Plasma - agg. (n=5)"
          ]
        }
      ]
    },
    {
      "Name": "Barone 1998a",
      "Classifications": [
        {
          "Name": "day 1 fasted",
          "Classifiables": [
            "Barone 1998a - day 1 fasted - Itraconazole - PO - 200 mg - Plasma - agg. (n=27)",
            "Barone 1998a - day 1 fasted - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=27)"
          ]
        },
        {
          "Name": "day 15 fasted",
          "Classifiables": [
            "Barone 1998a - day 15 fasted - Itraconazole - PO - 200 mg - Plasma - agg. (n=27)",
            "Barone 1998a - day 15 fasted - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=27)"
          ]
        },
        {
          "Name": "day 1 fed",
          "Classifiables": [
            "Barone 1998a - day 1 fed - Itraconazole - PO - 200 mg - Plasma - agg. (n=27)",
            "Barone 1998a - day 1 fed - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=27)"
          ]
        },
        {
          "Name": "day 15 fed",
          "Classifiables": [
            "Barone 1998a - day 15 fed - Itraconazole - PO - 200 mg - Plasma - agg. (n=27)",
            "Barone 1998a - day 15 fed - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=27)"
          ]
        }
      ]
    },
    {
      "Name": "Miura 2010",
      "Classifications": [
        {
          "Name": "po 100 mg MD Japanese",
          "Classifiables": [
            "Miura 2010 - po 100 mg MD Japanese - Itraconazole - PO - 200 mg - Plasma - agg. (n=6)",
            "Miura 2010 - po 100 mg MD Japanese - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=6)"
          ]
        }
      ]
    },
    {
      "Name": "Uno 2006",
      "Classifications": [
        {
          "Name": "day 1 (Japanese)",
          "Classifiables": [
            "Uno 2006 - day 1 (Japanese) - Itraconazole - PO - 200 mg - Plasma - agg. (n=8)",
            "Uno 2006 - day 1 (Japanese) - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=8)"
          ]
        },
        {
          "Name": "day 6 (Japanese)",
          "Classifiables": [
            "Uno 2006 - day 6 (Japanese) - Itraconazole - PO - 200 mg - Plasma - agg. (n=8)",
            "Uno 2006 - day 6 (Japanese) - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=8)"
          ]
        }
      ]
    },
    {
      "Name": "Gubbins 2004",
      "Classifications": [
        {
          "Name": "po 200 mg solution with water",
          "Classifiables": [
            "Gubbins 2004 - po 200 mg solution with water - Itraconazole - PO - 200 mg - Plasma - agg. (n=20)",
            "Gubbins 2004 - po 200 mg solution with water - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=20)"
          ]
        }
      ]
    },
    {
      "Name": "Gubbins 2007",
      "Classifications": [
        {
          "Name": "po 200 mg solution female with water",
          "Classifiables": [
            "Gubbins 2007 - po 200 mg solution female with water - Itraconazole - PO - 200 mg - Plasma - agg. (n=10)",
            "Gubbins 2007 - po 200 mg solution female with water - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=10)"
          ]
        },
        {
          "Name": "po 200 mg solution male with water",
          "Classifiables": [
            "Gubbins 2007 - po 200 mg solution male with water - Itraconazole - PO - 200 mg - Plasma - agg. (n=10)",
            "Gubbins 2007 - po 200 mg solution male with water - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=10)"
          ]
        }
      ]
    },
    {
      "Name": "Bae 2011",
      "Classifications": [
        {
          "Name": "po 200 mg capsule with water (Korean)",
          "Classifiables": [
            "Bae 2011 - po 200 mg capsule with water (Korean) - Itraconazole - PO - 200 mg - Plasma - agg. (n=12)",
            "Bae 2011 - po 200 mg capsule with water (Korean) - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=12)"
          ]
        },
        {
          "Name": "po 200 mg capsule with cola (Korean)",
          "Classifiables": [
            "Bae 2011 - po 200 mg capsule with cola (Korean) - Itraconazole - PO - 200 mg - Plasma - agg. (n=12)",
            "Bae 2011 - po 200 mg capsule with cola (Korean) - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=12)"
          ]
        },
        {
          "Name": "po 200 mg capsule with vit. C (Korean)",
          "Classifiables": [
            "Bae 2011 - po 200 mg capsule with vit. C (Korean) - Itraconazole - PO - 200 mg - Plasma - agg. (n=12)",
            "Bae 2011 - po 200 mg capsule with vit. C (Korean) - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=12)"
          ]
        }
      ]
    },
    {
      "Name": "Barone 1998b",
      "Classifications": [
        {
          "Name": "F05 Capsule",
          "Classifiables": [
            "Barone 1998b - F05 Capsule - Itraconazole - PO - 200 mg - Plasma - agg. (n=30)",
            "Barone 1998b - F05 Capsule - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=30)"
          ]
        },
        {
          "Name": "Solution",
          "Classifiables": [
            "Barone 1998b - Solution - Itraconazole - PO - 200 mg - Plasma - agg. (n=30)",
            "Barone 1998b - Solution - Hydroxy-Itraconazole - PO - 200 mg - Plasma - agg. (n=30)"
          ]
        }
      ]
    },
    {
      "Name": "Kivistö 1997",
      "Classifications": [
        {
          "Name": "with Perpetrator (Itraconazole)",
          "Classifiables": [
            "Kivistö 1997 - with Perpetrator (Itraconazole) - Itraconazole - PO - 100 mg - Plasma - agg. (n=8)"
          ]
        }
      ]
    },
    {
      "Name": "Templeton 2008",
      "Classifications": [
        {
          "Name": "ITZ day 1",
          "Classifiables": [
            "Templeton 2008 - ITZ day 1 - Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "ITZ day 7",
          "Classifiables": [
            "Templeton 2008 - ITZ day 7 - Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "OH-ITZ day 1",
          "Classifiables": [
            "Templeton 2008 - OH-ITZ day 1 - Hydroxy-Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "OH-ITZ day 7",
          "Classifiables": [
            "Templeton 2008 - OH-ITZ day 7 - Hydroxy-Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "keto-ITZ day 1",
          "Classifiables": [
            "Templeton 2008 - keto-ITZ day 1 - Keto-Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "keto-ITZ day 7",
          "Classifiables": [
            "Templeton 2008 - keto-ITZ day 7 - Keto-Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "ND-OH-ITZ day 1",
          "Classifiables": [
            "Templeton 2008 - ND-OH-ITZ day 1 - N-desalkyl-Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "ND-OH-ITZ day 7",
          "Classifiables": [
            "Templeton 2008 - ND-OH-ITZ day 7 - N-desalkyl-Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        }
      ]
    },
    {
      "Name": "Van de Velde 1996",
      "Classifications": [
        {
          "Name": "Fasting ITZ",
          "Classifiables": [
            "Van de Velde 1996 - Fasting ITZ - Itraconazole - PO - 100 mg - Plasma - agg. (n=12)"
          ]
        },
        {
          "Name": "Fasting OH-ITZ",
          "Classifiables": [
            "Van de Velde 1996 - Fasting OH-ITZ - Hydroxy-Itraconazole - PO - 100 mg - Plasma - agg. (n=12)"
          ]
        },
        {
          "Name": "Fed ITZ",
          "Classifiables": [
            "Van de Velde 1996 - Fed ITZ - Itraconazole - PO - 100 mg - Plasma - agg. (n=12)"
          ]
        },
        {
          "Name": "Fed OH-ITZ",
          "Classifiables": [
            "Van de Velde 1996 - Fed OH-ITZ - Hydroxy-Itraconazole - PO - 100 mg - Plasma - agg. (n=12)"
          ]
        }
      ]
    },
    {
      "Name": "Van Peer 1989",
      "Classifications": [
        {
          "Name": "100 mg Solution, fasting",
          "Classifiables": [
            "Van Peer 1989 - 100 mg Solution, fasting - Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "100 mg Capsules, fasting",
          "Classifiables": [
            "Van Peer 1989 - 100 mg Capsules, fasting - Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "100 mg Capsules, with food",
          "Classifiables": [
            "Van Peer 1989 - 100 mg Capsules, with food - Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "100 mg Capsules, with food, 15 days MD",
          "Classifiables": [
            "Van Peer 1989 - 100 mg Capsules, with food, 15 days MD - Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        }
      ]
    },
    {
      "Name": "Heykants 1989",
      "Classifications": [
        {
          "Name": "po 100 mg SD fed",
          "Classifiables": [
            "Heykants 1989 - po 100 mg SD fed - Itraconazole - PO - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "po 100 mg SD (metabolite screening)",
          "Classifiables": [
            "Heykants 1989 - po 100 mg SD (metabolite screening) - Itraconazole - PO - 100 mg - Plasma - agg. (n=24)",
            "Heykants 1989 - po 100 mg SD (metabolite screening) - Hydroxy-Itraconazole - PO - 100 mg - Plasma - agg. (n=24)"
          ]
        },
        {
          "Name": "po 100 mg MD OD",
          "Classifiables": [
            "Heykants 1989 - po 100 mg MD OD - Itraconazole - PO - 100 mg - Plasma - agg. (n=10)",
            "Heykants 1989 - po 100 mg MD OD - Hydroxy-Itraconazole - PO - 100 mg - Plasma - agg. (n=10)"
          ]
        },
        {
          "Name": "iv 100 mg SD",
          "Classifiables": [
            "Heykants 1989 - iv 100 mg SD - Itraconazole - IV - 100 mg - Plasma - agg. (n=6)"
          ]
        }
      ]
    },
    {
      "Name": "Mouton 2006",
      "Classifications": [
        {
          "Name": "SAD_B 100 mg",
          "Classifiables": [
            "Mouton 2006 - SAD_B 100 mg - Itraconazole - IV - 100 mg - Plasma - agg. (n=6)",
            "Mouton 2006 - SAD_B 100 mg - Hydroxy-Itraconazole - IV - 100 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "MAD_m_A 100 mg",
          "Classifiables": [
            "Mouton 2006 - MAD_m_A 100 mg - Itraconazole - IV - 100 mg - Plasma - agg. (n=4)",
            "Mouton 2006 - MAD_m_A 100 mg - Hydroxy-Itraconazole - IV - 100 mg - Plasma - agg. (n=4)"
          ]
        },
        {
          "Name": "MAD_m_A 100 mg (terminal phase only)",
          "Classifiables": [
            "Mouton 2006 - MAD_m_A 100 mg (terminal phase only) - Itraconazole - IV - 100 mg - Plasma - agg. (n=4)",
            "Mouton 2006 - MAD_m_A 100 mg (terminal phase only) - Hydroxy-Itraconazole - IV - 100 mg - Plasma - agg. (n=4)"
          ]
        },
        {
          "Name": "SAD_A 50 mg",
          "Classifiables": [
            "Mouton 2006 - SAD_A 50 mg - Itraconazole - IV - 50 mg - Plasma - agg. (n=6)",
            "Mouton 2006 - SAD_A 50 mg - Hydroxy-Itraconazole - IV - 50 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "SAD_A 200 mg",
          "Classifiables": [
            "Mouton 2006 - SAD_A 200 mg - Itraconazole - IV - 200 mg - Plasma - agg. (n=6)",
            "Mouton 2006 - SAD_A 200 mg - Hydroxy-Itraconazole - IV - 200 mg - Plasma - agg. (n=6)"
          ]
        },
        {
          "Name": "MAD_m_B 200 mg",
          "Classifiables": [
            "Mouton 2006 - MAD_m_B 200 mg - Itraconazole - IV - 200 mg - Plasma - agg. (n=4)",
            "Mouton 2006 - MAD_m_B 200 mg - Hydroxy-Itraconazole - IV - 200 mg - Plasma - agg. (n=4)"
          ]
        },
        {
          "Name": "MAD_m_D 200 mg (HPBCD)",
          "Classifiables": [
            "Mouton 2006 - MAD_m_D 200 mg (HPBCD) - Itraconazole - IV - 200 mg - Plasma - agg. (n=4)",
            "Mouton 2006 - MAD_m_D 200 mg (HPBCD) - Hydroxy-Itraconazole - IV - 200 mg - Plasma - agg. (n=4)"
          ]
        },
        {
          "Name": "MAD_m_B 200 mg (terminal phase only)",
          "Classifiables": [
            "Mouton 2006 - MAD_m_B 200 mg (terminal phase only) - Itraconazole - IV - 200 mg - Plasma - agg. (n=4)",
            "Mouton 2006 - MAD_m_B 200 mg (terminal phase only) - Hydroxy-Itraconazole - IV - 200 mg - Plasma - agg. (n=4)"
          ]
        },
        {
          "Name": "SAD_B 300 mg",
          "Classifiables": [
            "Mouton 2006 - SAD_B 300 mg - Itraconazole - IV - 300 mg - Plasma - agg. (n=2)",
            "Mouton 2006 - SAD_B 300 mg - Hydroxy-Itraconazole - IV - 300 mg - Plasma - agg. (n=2)"
          ]
        },
        {
          "Name": "MAD_m_C 300 mg",
          "Classifiables": [
            "Mouton 2006 - MAD_m_C 300 mg - Itraconazole - IV - 300 mg - Plasma - agg. (n=4)",
            "Mouton 2006 - MAD_m_C 300 mg - Hydroxy-Itraconazole - IV - 300 mg - Plasma - agg. (n=4)"
          ]
        },
        {
          "Name": "MAD_m_C 300 mg (terminal phase only)",
          "Classifiables": [
            "Mouton 2006 - MAD_m_C 300 mg (terminal phase only) - Itraconazole - IV - 300 mg - Plasma - agg. (n=4)",
            "Mouton 2006 - MAD_m_C 300 mg (terminal phase only) - Hydroxy-Itraconazole - IV - 300 mg - Plasma - agg. (n=4)"
          ]
        }
      ]
    },
    {
      "Name": "Zhou 1998",
      "Classifications": [
        {
          "Name": "IV 200 mg OD",
          "Classifiables": [
            "Zhou 1998 - IV 200 mg OD - Itraconazole - IV - 200 mg - Plasma - agg. (n=29)",
            "Zhou 1998 - IV 200 mg OD - Hydroxy-Itraconazole - IV - 200 mg - Plasma - agg. (n=29)"
          ]
        }
      ]
    },
    {
      "Name": "Abdel-Rahman 2007",
      "Classifiables": [
        "Abdel-Rahman 2007 - 2-6y - Itraconazole - IV - 2.5 mg/kg - Plasma - agg. (n=9)",
        "Abdel-Rahman 2007 - 6-12y - Itraconazole - IV - 2.5 mg/kg - Plasma - agg. (n=7)",
        "Abdel-Rahman 2007 - 6m-2y - Itraconazole - IV - 2.5 mg/kg - Plasma - agg. (n=6)",
        "Abdel-Rahman 2007 - 12-16y - Itraconazole - IV - 2.5 mg/kg - Plasma - agg. (n=11)"
      ]
    },
    {
      "Name": "Jalava 1997",
      "Classifiables": [
        "Jalava 1997 - po with Perpetrator (Itraconazole) - Itraconazole - PO - 200 mg - Plasma - agg. (n=10)"
      ]
    },
    {
      "Name": "Varhe 1994",
      "Classifiables": [
        "Varhe 1994 - Itraconazole on day 4 - Itraconazole - PO - 200 mg - Plasma - agg. (n=9)"
      ]
    },
    {
      "Name": "Neuvonen 1996",
      "Classifiables": [
        "Neuvonen 1996 - ITZ simultaneously with triazolam - Itraconazole - PO - 200 mg - Plasma - agg. (n=10)",
        "Neuvonen 1996 - ITZ 3 hr before triazolam - Itraconazole - PO - 200 mg - Plasma - agg. (n=10)",
        "Neuvonen 1996 - ITZ 12 hr before triazolam - Itraconazole - PO - 200 mg - Plasma - agg. (n=10)",
        "Neuvonen 1996 - ITZ 24 hr before triazolam - Itraconazole - PO - 200 mg - Plasma - agg. (n=10)"
      ]
    }
  ],
  "SimulationClassifications": [
    {
      "Name": "Adults",
      "Classifications": [
        {
          "Name": "iv",
          "Classifiables": [
            "100 mg IV SD",
            "200 mg IV MD"
          ]
        },
        {
          "Name": "po (capsule)",
          "Classifications": [
            {
              "Name": "fasted",
              "Classifiables": [
                "po 100 mg SD caps fast",
                "po 200 mg SD caps fast",
                "po 200 mg MD OD caps fast",
                "po 100 mg MD BID caps fast"
              ]
            },
            {
              "Name": "fed",
              "Classifiables": [
                "po 100 mg MD OD caps fed 2",
                "po 100 mg MD OD caps fed 1",
                "po 100 mg SD caps fed",
                "po 200 mg MD BID caps fed 1",
                "po 200 mg MD BID caps fed 2",
                "po 200 mg MD OD caps fed",
                "po 200 mg SD caps fed",
                "po 200 mg SD caps fed 2"
              ]
            }
          ]
        },
        {
          "Name": "po (solution)",
          "Classifications": [
            {
              "Name": "fed",
              "Classifiables": [
                "po 100 mg SD  sol fed",
                "po 200 mg SD sol fed",
                "po 200 mg MD OD sol fed"
              ]
            },
            {
              "Name": "fasted",
              "Classifiables": [
                "po 100 mg MD OD sol fast",
                "po 100 mg SD sol fast",
                "po 200 mg MD OD sol fast"
              ]
            }
          ]
        }
      ]
    },
    {
      "Name": "Pediatric",
      "Classifications": [
        {
          "Name": "IV",
          "Classifiables": [
            "Abdel-Rahman2007 0.5-2yr",
            "Abdel-Rahman2007 12-16yr",
            "Abdel-Rahman2007 2-6yr",
            "Abdel-Rahman2007 6-12yr"
          ]
        }
      ]
    }
  ]
}