{
  "Version": 80,
  "ExpressionProfiles": [
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP3A4",
      "Category": "Standard_Adult",
      "Parameters": [
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 1380.0,
          "Unit": "min"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 2220.0,
          "Unit": "min"
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "CYP3A4"
      }
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP1A1",
      "Category": "Standard_Adult",
      "Parameters": [
        {
          "Path": "CYP1A1|Reference concentration",
          "Value": 0.8454956,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Other",
            "Description": "Riociguat PBPK report"
          }
        },
        {
          "Path": "CYP1A1|t1/2 (intestine)",
          "Value": 1380.0,
          "Unit": "min"
        },
        {
          "Path": "CYP1A1|t1/2 (liver)",
          "Value": 2160.0,
          "Unit": "min"
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0057142857143
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0316642121
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0035198821797
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP1A1|Relative expression",
          "Value": 0.4394108984
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP1A1|Relative expression",
          "Value": 0.4394108984
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP1A1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0259204713
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0259204713
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0259204713
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0259204713
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0259204713
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP1A1|Relative expression",
          "Value": 0.0259204713
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT1A1",
      "Category": "Standard_Adult",
      "Parameters": [
        {
          "Path": "Organism|Gonads|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0013585313175
        },
        {
          "Path": "Organism|Kidney|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0788336933
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|Caecum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|UGT1A1|Relative expression",
          "Value": 0.00027429805616
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|Stomach|Intracellular|UGT1A1|Relative expression",
          "Value": 0.016349892
        },
        {
          "Path": "UGT1A1|Reference concentration",
          "Value": 1.328,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Publication",
            "Description": "Ohtsuki et al."
          }
        },
        {
          "Path": "UGT1A1|t1/2 (intestine)",
          "Value": 1380.0,
          "Unit": "min"
        },
        {
          "Path": "UGT1A1|t1/2 (liver)",
          "Value": 2160.0,
          "Unit": "min"
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "UGT1A1"
      }
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT1A9",
      "Category": "Standard_Adult",
      "Parameters": [
        {
          "Path": "Organism|Gonads|Intracellular|UGT1A9|Relative expression",
          "Value": 0.00016153846154
        },
        {
          "Path": "Organism|Kidney|Intracellular|UGT1A9|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|Caecum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0982905983
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0982905983
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|Stomach|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0017264957265
        },
        {
          "Path": "UGT1A9|Reference concentration",
          "Value": 10.36,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Publication",
            "Description": "Rodriguez-Antona et al."
          }
        },
        {
          "Path": "UGT1A9|t1/2 (intestine)",
          "Value": 1380.0,
          "Unit": "min"
        },
        {
          "Path": "UGT1A9|t1/2 (liver)",
          "Value": 2160.0,
          "Unit": "min"
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "UGT1A1"
      }
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "Cleavage-protein",
      "Category": "Standard_Adult",
      "Parameters": [
        {
          "Path": "Cleavage-protein|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "Cleavage-protein|t1/2 (intestine)",
          "Value": 1380.0,
          "Unit": "min"
        },
        {
          "Path": "Cleavage-protein|t1/2 (liver)",
          "Value": 2160.0,
          "Unit": "min"
        },
        {
          "Path": "Organism|Lumen|Caecum|Cleavage-protein|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lumen|ColonAscendens|Cleavage-protein|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lumen|ColonDescendens|Cleavage-protein|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lumen|ColonSigmoid|Cleavage-protein|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lumen|ColonTransversum|Cleavage-protein|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lumen|Rectum|Cleavage-protein|Relative expression",
          "Value": 1.0
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
    },
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "ABCG2",
      "Category": "Standard_Adult",
      "Parameters": [
        {
          "Path": "ABCG2|Reference concentration",
          "Value": 9.2028777,
          "Unit": "nmol/l",
          "ValueOrigin": {
            "Source": "Publication",
            "Description": "Tucker et al."
          }
        },
        {
          "Path": "ABCG2|t1/2 (intestine)",
          "Value": 1380.0,
          "Unit": "min"
        },
        {
          "Path": "ABCG2|t1/2 (liver)",
          "Value": 2160.0,
          "Unit": "min"
        },
        {
          "Path": "Organism|Bone|Intracellular|ABCG2|Relative expression",
          "Value": 0.2113821138
        },
        {
          "Path": "Organism|Brain|Intracellular|ABCG2|Relative expression",
          "Value": 0.4552845528
        },
        {
          "Path": "Organism|Gonads|Intracellular|ABCG2|Relative expression",
          "Value": 0.2703252033
        },
        {
          "Path": "Organism|Heart|Intracellular|ABCG2|Relative expression",
          "Value": 0.1099593496
        },
        {
          "Path": "Organism|Kidney|Intracellular|ABCG2|Relative expression",
          "Value": 0.0941056911
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ABCG2|Relative expression",
          "Value": 0.1593495935
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|Caecum|Intracellular|ABCG2|Relative expression",
          "Value": 0.1593495935
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCG2|Relative expression",
          "Value": 0.1593495935
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCG2|Relative expression",
          "Value": 0.1593495935
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCG2|Relative expression",
          "Value": 0.1593495935
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCG2|Relative expression",
          "Value": 0.1593495935
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ABCG2|Relative expression",
          "Value": 0.2825203252
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ABCG2|Relative expression",
          "Value": 0.2825203252
        },
        {
          "Path": "Organism|Lung|Intracellular|ABCG2|Relative expression",
          "Value": 0.2154471545
        },
        {
          "Path": "Organism|Muscle|Intracellular|ABCG2|Relative expression",
          "Value": 0.0331300813
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ABCG2|Relative expression",
          "Value": 0.0054268292683
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ABCG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Spleen|Intracellular|ABCG2|Relative expression",
          "Value": 0.0585365854
        },
        {
          "Path": "Organism|Stomach|Intracellular|ABCG2|Relative expression",
          "Value": 0.0404471545
        }
      ],
      "TransportType": "Efflux",
      "Expression": [
        {
          "Name": "Bone",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainInterstitialToPlasma",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainTissueToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Lung",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Muscle",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pancreas",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Skin",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Spleen",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "BloodCells",
          "TransportDirection": "EffluxBloodCellsToPlasma"
        },
        {
          "Name": "VascularEndothelium",
          "TransportDirection": "EffluxInterstitialToPlasma"
        }
      ]
    },
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "ABCB1",
      "Category": "Standard_Adult",
      "Parameters": [
        {
          "Path": "ABCB1|Reference concentration",
          "Value": 96.57,
          "Unit": "nmol/l",
          "ValueOrigin": {
            "Source": "Publication",
            "Description": "Tucker et al."
          }
        },
        {
          "Path": "ABCB1|t1/2 (intestine)",
          "Value": 1380.0,
          "Unit": "min"
        },
        {
          "Path": "ABCB1|t1/2 (liver)",
          "Value": 2160.0,
          "Unit": "min"
        },
        {
          "Path": "Organism|Bone|Intracellular|ABCB1|Relative expression",
          "Value": 0.0341950646
        },
        {
          "Path": "Organism|Brain|Intracellular|ABCB1|Relative expression",
          "Value": 0.1072855464
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        {
          "Path": "Organism|Gonads|Intracellular|ABCB1|Relative expression",
          "Value": 0.024559342
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        {
          "Path": "Organism|Heart|Intracellular|ABCB1|Relative expression",
          "Value": 0.059106933
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        {
          "Path": "Organism|Kidney|Intracellular|ABCB1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.1562867215
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        {
          "Path": "Organism|LargeIntestine|Mucosa|Caecum|Intracellular|ABCB1|Relative expression",
          "Value": 0.1562867215
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.1562867215
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCB1|Relative expression",
          "Value": 0.1562867215
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCB1|Relative expression",
          "Value": 0.1562867215
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCB1|Relative expression",
          "Value": 0.1562867215
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ABCB1|Relative expression",
          "Value": 0.2702702703
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ABCB1|Relative expression",
          "Value": 0.2702702703
        },
        {
          "Path": "Organism|Lung|Intracellular|ABCB1|Relative expression",
          "Value": 0.0927144536
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        {
          "Path": "Organism|Muscle|Intracellular|ABCB1|Relative expression",
          "Value": 0.0180963572
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        {
          "Path": "Organism|Pancreas|Intracellular|ABCB1|Relative expression",
          "Value": 0.0200940071
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ABCB1|Relative expression",
          "Value": 0.3960047004
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3960047004
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3960047004
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3960047004
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3960047004
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression",
          "Value": 0.3960047004
        },
        {
          "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression",
          "Value": 0.1047003525
        },
        {
          "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression",
          "Value": 0.0367802585
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      ],
      "TransportType": "PgpLike",
      "Expression": [
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          "Name": "Bone",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
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        {
          "Name": "Brain",
          "TransportDirection": "PgpBrainInterstitialToPlasma",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "PgpBrainTissueToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
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        {
          "Name": "Heart",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
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        {
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          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
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        {
          "Name": "Stomach",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
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        {
          "Name": "SmallIntestine",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
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        {
          "Name": "Duodenum",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "Duodenum",
          "TransportDirection": "PgpMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
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        {
          "Name": "UpperJejunum",
          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "UpperJejunum",
          "TransportDirection": "PgpMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
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        {
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          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
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        {
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        {
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          "TransportDirection": "PgpMucosaIntracellularToLumen",
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        {
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          "TransportDirection": "PgpIntracellularToInterstitial",
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        {
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          "TransportDirection": "PgpMucosaIntracellularToLumen",
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          "TransportDirection": "PgpMucosaIntracellularToLumen",
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          "TransportDirection": "PgpIntracellularToInterstitial",
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        {
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          "CompartmentName": "Interstitial"
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        {
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          "TransportDirection": "PgpMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
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        {
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          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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          "CompartmentName": "Interstitial"
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        {
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          "TransportDirection": "PgpMucosaIntracellularToLumen",
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        {
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          "TransportDirection": "PgpIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
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          "TransportDirection": "PgpIntracellularToInterstitial",
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          "CompartmentName": "Intracellular"
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          "TransportDirection": "PgpIntracellularToInterstitial",
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          "TransportDirection": "PgpIntracellularToInterstitial",
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        {
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          "TransportDirection": "EffluxBloodCellsToPlasma"
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        {
          "Name": "VascularEndothelium",
          "TransportDirection": "EffluxInterstitialToPlasma"
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        "Name": "Ontogeny for ABCB1.Edginton_2006.Table",
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    },
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      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "M-1 TS",
      "Category": "Standard_Adult",
      "Parameters": [
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          "Path": "M-1 TS|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "M-1 TS|t1/2 (intestine)",
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          "Unit": "min"
        },
        {
          "Path": "M-1 TS|t1/2 (liver)",
          "Value": 2160.0,
          "Unit": "min"
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        {
          "Path": "Organism|Kidney|Intracellular|M-1 TS|Relative expression",
          "Value": 1.0
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      "TransportType": "Efflux",
      "Expression": [
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          "Name": "Bone",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
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        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainInterstitialToPlasma",
          "CompartmentName": "Plasma"
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        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainTissueToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "Fat",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
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        {
          "Name": "Gonads",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
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        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "Caecum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
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        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
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        {
          "Name": "Rectum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
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                "Hamaguchi 1987 - Treatment 3 - fasted with 500 mL of water - Mefenamic acid - PO - 250 mg - Plasma - agg. (n=4)"
              ]
            },
            {
              "Name": "Treatment 4 - fed with 50 mL of water",
              "Classifiables": [
                "Hamaguchi 1987 - Treatment 4 - fed with 50 mL of water - Mefenamic acid - PO - 250 mg - Plasma - agg. (n=4)"
              ]
            }
          ]
        },
        {
          "Name": "Goosen 2017",
          "Classifiables": [
            "Goosen 2017 - 500 mg SD - Mefenamic acid - PO - 500 mg - Plasma - agg."
          ]
        }
      ]
    }
  ]
}