{ "$schema": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/QualificationPlan/v2.3/schemas/OSP_Qualification_Plan_Schema.json", "Projects": [ { "Id": "Alfentanil", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Alfentanil-Model/v2.2/Alfentanil-Model.json" }, { "Id": "Alprazolam", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Alprazolam-Model/v1.1/Alprazolam-Model.json" }, { "Id": "Carbamazepine", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Carbamazepine-Model/v1.3/Carbamazepine-Model.json" }, { "Id": "Cimetidine", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Cimetidine-Model/v1.2/Cimetidine-Model.json" }, { "Id": "Clarithromycin", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Clarithromycin-Model/v1.2/Clarithromycin-Model.json" }, { "Id": "Efavirenz", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Efavirenz-Model/v1.1/Efavirenz-Model.json" }, { "Id": "Erythromycin", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Erythromycin-Model/v1.3/Erythromycin-Model.json" }, { "Id": "Fluconazole", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Fluconazole-Model/v1.0/Fluconazole-Model.json" }, { "Id": "Fluvoxamine", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Fluvoxamine-Model/v1.2/Fluvoxamine-Model.json" }, { "Id": "Itraconazole", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Itraconazole-Model/v1.3/Itraconazole-Model.json" }, { "Id": "Midazolam", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Midazolam-Model/v1.1/Midazolam-Model.json" }, { "Id": "Rifampicin", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Rifampicin-Model/v1.2/Rifampicin-Model.json" }, { "Id": "Triazolam", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Triazolam-Model/v1.1/Triazolam-Model.json" }, { "Id": "Verapamil", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Verapamil-Model/v1.2/Verapamil-Model.json" }, { "Id": "Carbamazepine-Alprazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Carbamazepine-Alprazolam-DDI/v1.1/Carbamazepine-Alprazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Alprazolam", "Project": "Alprazolam" }, { "Type": "Formulation", "Name": "Solanax", "Project": "Alprazolam" }, { "Type": "Compound", "Name": "Carbamazepine", "Project": "Carbamazepine" }, { "Type": "Formulation", "Name": "CBZ_tabletIR_fasted (Tegretol)", "Project": "Carbamazepine" } ], "SimulationParameters": [ { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Furukori1998_ControlPhase", "Furukori1998_TreatmentPhase" ] } ] }, { "Id": "Carbamazepine-Efavirenz-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Carbamazepine-Efavirenz-DDI/v1.1/Carbamazepine-Efavirenz-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Carbamazepine", "Project": "Carbamazepine" }, { "Type": "Formulation", "Name": "CBZ_tabletIR_fasted (Tegretol)", "Project": "Carbamazepine" }, { "Type": "Compound", "Name": "Efavirenz", "Project": "Efavirenz" }, { "Type": "Formulation", "Name": "Sustiva", "Project": "Efavirenz" } ], "SimulationParameters": [ ] }, { "Id": "Carbamazepine-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Carbamazepine-Midazolam-DDI/v1.0/Carbamazepine-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Formulation", "Name": "Oral solution", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Carbamazepine", "Project": "Carbamazepine" }, { "Type": "Formulation", "Name": "CBZ_tabletIR_fasted (Tegretol)", "Project": "Carbamazepine" }, { "Type": "Formulation", "Name": "CBZ_capsuleXR_fasted (Carbatrol)", "Project": "Carbamazepine" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Kanefendt2023_Study1_ControlPhase", "Kanefendt2023_Study1_TreatmentPhase", "Kanefendt2023_Study2_ControlPhase", "Kanefendt2023_Study2_TreatmentPhase", "Lutz2018_ControlPhase", "Lutz2018_TreatmentPhase" ] } ] }, { "Id": "Cimetidine-Alfentanil-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Cimetidine-Alfentanil-DDI/v1.2/Cimetidine-Alfentanil-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Alfentanil", "Project": "Alfentanil" }, { "Type": "Compound", "Name": "Cimetidine", "Project": "Cimetidine" } ], "SimulationParameters": [ { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kienlen 1993 - Alfentanil iv control", "Kienlen 1993 - Alfentanil iv + Cimetidine iv" ] } ] }, { "Id": "Cimetidine-Alprazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Cimetidine-Alprazolam-DDI/v1.2/Cimetidine-Alprazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Alprazolam", "Project": "Alprazolam" }, { "Type": "Formulation", "Name": "Xanax_IR", "Project": "Alprazolam" }, { "Type": "Compound", "Name": "Cimetidine", "Project": "Cimetidine" }, { "Type": "Formulation", "Name": "Tablet", "Project": "Cimetidine" } ], "SimulationParameters": [ { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983 - Alprazolam 1 mg control", "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID" ] } ] }, { "Id": "Cimetidine-Carbamazepine-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Cimetidine-Carbamazepine-DDI/v1.1/Cimetidine-Carbamazepine-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Cimetidine", "Project": "Cimetidine" }, { "Type": "Formulation", "Name": "Tablet", "Project": "Cimetidine" }, { "Type": "Compound", "Name": "Carbamazepine", "Project": "Carbamazepine" }, { "Type": "Formulation", "Name": "CBZ_tabletIR_fasted (Tegretol)", "Project": "Carbamazepine" } ], "SimulationParameters": [ ] }, { "Id": "Cimetidine-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Cimetidine-Midazolam-DDI/v1.2/Cimetidine-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Formulation", "Name": "Tablet (Dormicum)", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Cimetidine", "Project": "Cimetidine" }, { "Type": "Formulation", "Name": "Tablet", "Project": "Cimetidine" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1986, Midazolam iv control", "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Greenblatt 1986, Midazolam po control", "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Fee 1987, Midazolam po control", "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Salonen 1986, Midazolam po control", "Salonen 1986, Midazolam po + 400 mg cimetidine", "Martinez 1999, Midazolam po control", "Martinez 1999, Midazolam po + 800 mg cimetidine", "Elliott 1984, Midazolam po control", "Elliott 1984, Midazolam po + 200/400 mg cimetidine" ] } ] }, { "Id": "Cimetidine-Triazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Cimetidine-Triazolam-DDI/v1.2/Cimetidine-Triazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Triazolam", "Project": "Triazolam" }, { "Type": "Formulation", "Name": "Halcion", "Project": "Triazolam" }, { "Type": "Compound", "Name": "Cimetidine", "Project": "Cimetidine" }, { "Type": "Formulation", "Name": "Tablet", "Project": "Cimetidine" } ], "SimulationParameters": [ { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Abernethy 1983/Friedman 1988 - Triazolam control", "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Pourbaix 1985 - Triazolam control", "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Cox 1986 - Triazolam intraduodenal control", "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID" ] } ] }, { "Id": "Cimetidine-Verapamil-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Cimetidine-Verapamil-DDI/v1.2/Cimetidine-Verapamil-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Cimetidine", "Project": "Cimetidine" }, { "Type": "Compound", "Name": "Verapamil", "Project": "Verapamil" }, { "Type": "Formulation", "Name": "Tablet", "Project": "Cimetidine" } ], "SimulationParameters": [ { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "Smith 1984 - Verapamil 10 mg iv control", "Smith 1984 - Verapamil 120 mg po control", "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid" ] } ] }, { "Id": "Clarithromycin-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Clarithromycin-Midazolam-DDI/v1.2/Clarithromycin-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Formulation", "Name": "Tablet (Dormicum)", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Clarithromycin", "Project": "Clarithromycin" }, { "Type": "Formulation", "Name": "Tablet Clarithromycin", "Project": "Clarithromycin" }, { "Type": "Compound", "Name": "Rifampicin", "Project": "Rifampicin" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv", "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008a", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - iv - Quinney 2008", "DDI Control - Midazolam - po - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018" ] }, { "Project": "Clarithromycin", "Simulation": "Clarithromycin po, Chu 1992, 100 mg", "Path": "Clarithromycin|P (blood cells->plasma)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5" ] }, { "Project": "Clarithromycin", "Simulation": "Clarithromycin po, Chu 1992, 100 mg", "Path": "Clarithromycin|P (plasma->blood cells)", "TargetSimulations": [ "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "DDI Treatment - Clarithromycin/Midazolam - van Dyk 2018", "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5" ] } ] }, { "Id": "Clarithromycin-Triazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Clarithromycin-Triazolam-DDI/v1.2/Clarithromycin-Triazolam_DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Triazolam", "Project": "Triazolam" }, { "Type": "Formulation", "Name": "Halcion", "Project": "Triazolam" }, { "Type": "Compound", "Name": "Clarithromycin", "Project": "Clarithromycin" }, { "Type": "Formulation", "Name": "Tablet Clarithromycin", "Project": "Clarithromycin" } ], "SimulationParameters": [ { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Clarithromycin", "Simulation": "Clarithromycin po, Chu 1992, 100 mg", "Path": "Clarithromycin|P (blood cells->plasma)", "TargetSimulations": [ "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] }, { "Project": "Clarithromycin", "Simulation": "Clarithromycin po, Chu 1992, 100 mg", "Path": "Clarithromycin|P (plasma->blood cells)", "TargetSimulations": [ "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO" ] } ] }, { "Id": "Efavirenz-Carbamazepine-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Efavirenz-Carbamazepine-DDI/v1.0/Efavirenz-Carbamazepine-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Carbamazepine", "Project": "Carbamazepine" }, { "Type": "Formulation", "Name": "CBZ_tabletIR_fasted (Tegretol)", "Project": "Carbamazepine" }, { "Type": "Compound", "Name": "Efavirenz", "Project": "Efavirenz" }, { "Type": "Formulation", "Name": "Sustiva", "Project": "Efavirenz" } ], "SimulationParameters": [ ] }, { "Id": "Erythromycin-Alfentanil-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Erythromycin-Alfentanil-DDI/v1.2/Erythromycin-Alfentanil-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Alfentanil", "Project": "Alfentanil" }, { "Type": "Compound", "Name": "Erythromycin", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_enteric-coated-tablet", "Project": "Erythromycin" } ], "SimulationParameters": [ { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Bartkowski1989_Control", "Bartkowski1989_Perpetrator_Day7", "Bartkowski1989_Perpetrator_Day1" ] } ] }, { "Id": "Erythromycin-Alprazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Erythromycin-Alprazolam-DDI/v1.2/Erythromycin-Alprazolam-DDI.json", "BuildingBlocks": [ { "Type": "Individual", "Name": "Japanese (Yasui studies)", "Project": "Alprazolam" }, { "Type": "Compound", "Name": "Alprazolam", "Project": "Alprazolam" }, { "Type": "Formulation", "Name": "Xanax_IR", "Project": "Alprazolam" }, { "Type": "Compound", "Name": "Erythromycin", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_filmtablet", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Solanax", "Project": "Alprazolam" } ], "SimulationParameters": [ { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui1996_Control", "Yasui1996_Perpetrator" ] } ] }, { "Id": "Erythromycin-Carbamazepine-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Erythromycin-Carbamazepine-DDI/v1.1/Erythromycin-Carbamazepine-DDI.json", "BuildingBlocks": [ { "Type": "Individual", "Name": "Barzaghi1987", "Project": "Carbamazepine" }, { "Type": "Individual", "Name": "Miles1989", "Project": "Carbamazepine" }, { "Type": "Individual", "Name": "Wong1983", "Project": "Carbamazepine" }, { "Type": "Compound", "Name": "Carbamazepine", "Project": "Carbamazepine" }, { "Type": "Formulation", "Name": "CBZ_tabletIR_fasted (Tegretol)", "Project": "Carbamazepine" }, { "Type": "Compound", "Name": "Erythromycin", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_enteric-coated-pellets", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_filmtablet", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_filmtablet_250mg", "Project": "Erythromycin" } ], "SimulationParameters": [ ] }, { "Id": "Erythromycin-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Erythromycin-Midazolam-DDI/v1.2/Erythromycin-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Formulation", "Name": "Tablet (Dormicum)", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Erythromycin", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_filmtablet", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_filmtablet_250mg", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_enteric-coated-tablet", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_enteric-coated-pellets", "Project": "Erythromycin" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Control_Carls2014", "Control_Okudaira2007_EM0", "Control_Olkkola1993_IV", "Control_Olkkola1993_Oral", "Control_Swart2002", "Control_Zimmermann1996", "Treatment_Carls2014_1000mg", "Treatment_Carls2014_250mg", "Treatment_Okudaira2007_EM2", "Treatment_Okudaira2007_EM4", "Treatment_Okudaira2007_EM7", "Treatment_Olkkola1993_IV", "Treatment_Olkkola1993_Oral", "Treatment_Swart2002", "Treatment_Zimmermann1996" ] } ] }, { "Id": "Erythromycin-Triazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Erythromycin-Triazolam-DDI/v1.2/Erythromycin-Triazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Triazolam", "Project": "Triazolam" }, { "Type": "Formulation", "Name": "Halcion", "Project": "Triazolam" }, { "Type": "Compound", "Name": "Erythromycin", "Project": "Erythromycin" }, { "Type": "Formulation", "Name": "Erythromycin_Weibull_enteric-coated-tablet", "Project": "Erythromycin" } ], "SimulationParameters": [ { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Greenblatt1998_Control", "Greenblatt1998_Perpetrator", "Phillips1986_Control", "Phillips1986_Perpetrator" ] } ] }, { "Id": "Fluconazole-Alfentanil-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Fluconazole-Alfentanil-DDI/v1.0/Fluconazole-Alfentanil-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Fluconazole", "Project": "Fluconazole" }, { "Type": "Formulation", "Name": "Fluconazole_Weibull_high dose", "Project": "Fluconazole" }, { "Type": "Compound", "Name": "Alfentanil", "Project": "Alfentanil" } ], "SimulationParameters": [ ] }, { "Id": "Fluconazole-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Fluconazole-Midazolam-DDI/v1.0/Fluconazole-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Fluconazole", "Project": "Fluconazole" }, { "Type": "Formulation", "Name": "Fluconazole_Weibull_high dose", "Project": "Fluconazole" }, { "Type": "Formulation", "Name": "Fluconazole_Weibull_medium high dose", "Project": "Fluconazole" }, { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Formulation", "Name": "Tablet (Dormicum)", "Project": "Midazolam" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Ahonen_midazolam_po_7.5mg_placebo", "Olkkola_midazolam_fluconazole_DDI_day 1", "Olkkola_midazolam_fluconazole_DDI_day 4", "Olkkola_midazolam_fluconazole_DDI_day 6", "Olkkola_midazolam_placebo_day 1", "Olkkola_midazolam_placebo_day 4", "Olkkola_midazolam_placebo_day 6" ] } ] }, { "Id": "Fluconazole-Triazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Fluconazole-Triazolam-DDI/v1.0/Fluconazole-Triazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Fluconazole", "Project": "Fluconazole" }, { "Type": "Formulation", "Name": "Fluconazole_Weibull_low dose", "Project": "Fluconazole" }, { "Type": "Formulation", "Name": "Fluconazole_Weibull_medium high dose", "Project": "Fluconazole" }, { "Type": "Compound", "Name": "Triazolam", "Project": "Triazolam" }, { "Type": "Formulation", "Name": "Halcion", "Project": "Triazolam" } ], "SimulationParameters": [ { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Varhe triazolam 0.25 mg po fluconazole 100mg", "Varhe triazolam 0.25 mg po placebo", "Varhe triazolam 0.25 mg po fluconazole 200mg", "Varhe triazolam 0.25 mg po fluconazole 50mg" ] } ] }, { "Id": "Fluvoxamine-Alprazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Fluvoxamine-Alprazolam-DDI/v1.1/Fluvoxamine-Alprazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Fluvoxamine", "Project": "Fluvoxamine" }, { "Type": "Compound", "Name": "Alprazolam", "Project": "Alprazolam" }, { "Type": "Formulation", "Name": "Xanax_IR", "Project": "Alprazolam" }, { "Type": "Formulation", "Name": "Solanax", "Project": "Alprazolam" } ], "SimulationParameters": [ { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Fleishaker1994_Alprazolam", "Fleishaker1994_Fluvoxamine_Alprazolam" ] } ] }, { "Id": "Fluvoxamine-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Fluvoxamine-Midazolam-DDI/v1.2/Fluvoxamine-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Fluvoxamine", "Project": "Fluvoxamine" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Lam 2003, 10 mg, SD, midazolam control", "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "DDI Control - Midazolam - Kashuba 1998" ] } ] }, { "Id": "Itraconazole-Alprazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Itraconazole-Alprazolam-DDI/v1.2/Itraconazole-Alprazolam-DDI.json", "BuildingBlocks": [ { "Type": "Individual", "Name": "Japanese (Yasui studies)", "Project": "Alprazolam" }, { "Type": "Compound", "Name": "Alprazolam", "Project": "Alprazolam" }, { "Type": "Compound", "Name": "Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "Hydroxy-Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "Keto-Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "N-desalkyl-Itraconazole", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Capsule fasted", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Capsule fed", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Xanax_IR", "Project": "Alprazolam" }, { "Type": "Formulation", "Name": "Solanax", "Project": "Alprazolam" } ], "SimulationParameters": [ { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Yasui 1998 - Alprazolam 0.8 mg with itraconazole" ] } ] }, { "Id": "Itraconazole-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Itraconazole-Midazolam-DDI/v1.2/Itraconazole-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Individual", "Name": "Korean (Yu 2004 study)", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "Hydroxy-Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "Keto-Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "N-desalkyl-Itraconazole", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Capsule fasted", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Capsule fed", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Tablet (Dormicum)", "Project": "Midazolam" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "DDI Control - Midazolam - Olkkola 1994", "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "DDI Control - Midazolam - Ahonen 1995", "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "DDI Control - Midazolam - Templeton 2010", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)" ] } ] }, { "Id": "Itraconazole-Triazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Itraconazole-Triazolam-DDI/v1.2/Itraconazole-Triazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Triazolam", "Project": "Triazolam" }, { "Type": "Compound", "Name": "Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "Hydroxy-Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "Keto-Itraconazole", "Project": "Itraconazole" }, { "Type": "Compound", "Name": "N-desalkyl-Itraconazole", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Capsule fasted", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Capsule fed", "Project": "Itraconazole" }, { "Type": "Formulation", "Name": "Halcion", "Project": "Triazolam" }, { "Type": "Event", "Name": "Standard Meal", "Project": "Itraconazole" } ], "SimulationParameters": [ { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] }, { "Project": "Triazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Neuvonen 1996 - Triazolam 0.25 mg control", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Varhe 1994 - Triazolam 0.25 mg control", "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD" ] } ] }, { "Id": "Verapamil-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Verapamil-Midazolam-DDI/v1.3/Verapamil-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Verapamil", "Project": "Verapamil" }, { "Type": "Formulation", "Name": "controlled release", "Project": "Verapamil" }, { "Type": "Formulation", "Name": "Tablet (Dormicum)", "Project": "Midazolam" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Control - Midazolam - Wang 2005", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Treatment - Verapamil/Midazolam - Backman 1994", "DDI Treatment - Verapamil/Midazolam - Wang 2005" ] } ] }, { "Id": "Efavirenz-Alfentanil-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Efavirenz-Alfentanil-DDI/v1.1/Efavirenz-Alfentanil-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Efavirenz", "Project": "Efavirenz" }, { "Type": "Formulation", "Name": "Sustiva", "Project": "Efavirenz" }, { "Type": "Compound", "Name": "Alfentanil", "Project": "Alfentanil" }, { "Type": "Formulation", "Name": "Solution", "Project": "Alfentanil" } ], "SimulationParameters": [ { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2004, Alfentanil po 0.06 mg/kg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 2012, Alfentanil IV alone", "Kharasch 2012, Alfentanil PO alone", "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD" ] } ] }, { "Id": "Efavirenz-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Efavirenz-Midazolam-DDI/v1.2/Efavirenz-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Efavirenz", "Project": "Efavirenz" }, { "Type": "Formulation", "Name": "Sustiva", "Project": "Efavirenz" }, { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Mikus 2017, Midazolam alone", "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Katzenmaier 2010, Midazolam alone", "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD" ] } ] }, { "Id": "Rifampicin-Alfentanil-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Rifampicin-Alfentanil-DDI/v1.2/Rifampicin-Alfentanil-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Alfentanil", "Project": "Alfentanil" }, { "Type": "Compound", "Name": "Rifampicin", "Project": "Rifampicin" } ], "SimulationParameters": [ { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (interstitial->intracellular)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] }, { "Project": "Alfentanil", "Simulation": "Kharasch 2011b, Alfentanil PO 4 mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alfentanil|P (intracellular->interstitial)", "TargetSimulations": [ "Kharasch 1997 20 µg/kg IV - control", "Kharasch 1997 20 µg/kg IV and Rifampicin", "Kharasch 2004 15 µg/kg IV - control", "Kharasch 2004 15 µg/kg IV and Rifampicin", "Kharasch 2004 60 µg/kg PO - control", "Kharasch 2004 60 µg/kg PO and Rifampicin", "Kharasch 2011 15 µg/kg IV - control", "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Kharasch 2011 75 µg/kg PO - control", "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Kharasch 2011b IV 1mg - control", "Kharasch 2011b PO 4mg - control", "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Phimmasone 2001 15 µg/kg IV - control", "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin" ] } ] }, { "Id": "Rifampicin-Alprazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Rifampicin-Alprazolam-DDI/v1.2/Rifampicin-Alprazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Rifampicin", "Project": "Rifampicin" }, { "Type": "Compound", "Name": "Alprazolam", "Project": "Alprazolam" }, { "Type": "Formulation", "Name": "Xanax_IR", "Project": "Alprazolam" } ], "SimulationParameters": [ { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] }, { "Project": "Alprazolam", "Simulation": "PO_0.5mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Alprazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Gashaw 2003 - Alprazolam control", "Gashaw 2003 - Alprazolam + Rifampicin", "Schmider 1999 - Alprazolam control", "Schmider 1999 - Alprazolam + Rifampicin" ] } ] }, { "Id": "Rifampicin-Midazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Rifampicin-Midazolam-DDI/v1.2/Rifampicin-Midazolam-DDI.json", "BuildingBlocks": [ { "Type": "Individual", "Name": "Korean (Yu 2004 study)", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Midazolam", "Project": "Midazolam" }, { "Type": "Compound", "Name": "Rifampicin", "Project": "Rifampicin" }, { "Type": "Formulation", "Name": "Tablet (Dormicum)", "Project": "Midazolam" } ], "SimulationParameters": [ { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] }, { "Project": "Midazolam", "Simulation": "po 3 mg (solution)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Midazolam|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Midazolam - Backman 1996", "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "DDI Control - Midazolam - Backman 1998", "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "DDI Control - Midazolam - Chung 2006", "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "DDI Control - Midazolam - Eap 2004 (0.075 mg)", "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "DDI Control - Midazolam - Gorski 2003 (iv)", "DDI Control - Midazolam - Gorski 2003 (po)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "DDI Control - Midazolam - Gurley 2006", "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "DDI Control - Midazolam - Gurley 2008", "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "DDI Control - Midazolam - Kharasch 2004 (iv)", "DDI Control - Midazolam - Kharasch 2004 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "DDI Control - Midazolam - Kharasch 2011 (iv)", "DDI Control - Midazolam - Kharasch 2011 (po)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "DDI Control - Midazolam - Link 2008 (iv)", "DDI Control - Midazolam - Link 2008 (po)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "DDI Control - Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "DDI Control - Midazolam - Szalat 2007", "DDI Control - Midazolam - van Dyk 2018", "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "DDI Control - Midazolam - Prueksaritanont 2017", "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "DDI Control - Midazolam - Shin 2013", "DDI Control - Midazolam - Shin 2016", "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "DDI Control - Midazolam - Kim 2018 (male)", "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "DDI Control - Midazolam - Kharasch 1997", "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "DDI Control - Midazolam - Wiesinger 2020", "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Control - Midazolam - Lutz 2018 (po)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "DDI Control - Midazolam - Björkhem-Bergman 2013", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "DDI Control - Midazolam - Chattopadhyay 2018", "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018" ] } ] }, { "Id": "Rifampicin-Triazolam-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Rifampicin-Triazolam-DDI/v1.2/Rifampicin-Triazolam-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Rifampicin", "Project": "Rifampicin" }, { "Type": "Compound", "Name": "Triazolam", "Project": "Triazolam" }, { "Type": "Formulation", "Name": "Halcion", "Project": "Triazolam" } ], "SimulationParameters": [ { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (interstitial->intracellular)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] }, { "Project": "Triazolam", "Simulation": "PO_0.125mg", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (intracellular->interstitial)", "TargetSimulations": [ "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO" ] } ] }, { "Id": "Rifampicin-Verapamil-DDI", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Rifampicin-Verapamil-DDI/v1.1/Rifampicin-Verapamil-DDI.json", "BuildingBlocks": [ { "Type": "Compound", "Name": "Rifampicin", "Project": "Rifampicin" }, { "Type": "Compound", "Name": "Verapamil", "Project": "Verapamil" } ], "SimulationParameters": [ { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] }, { "Project": "Verapamil", "Simulation": "Barbarash 1988 + Johnston 1981 + McAllister 1982 +Hla 1987 (120 mg PO SD)", "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (intracellular->interstitial)", "TargetSimulations": [ "DDI Control - Verapamil - Barbarash 1988 (iv)", "DDI Control - Verapamil - Barbarash 1988 (po)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)" ] } ] } ], "ObservedDataSets": [ { "Id": "DDI Ratios", "Path": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Database-for-observed-data/v1.5/DDI.csv", "Type": "DDIRatio" } ], "Plots": { "AxesSettings": { "GOFMergedPlotsPredictedVsObserved": [ { "Type": "X", "Dimension": "Concentration (mass)", "Unit": "ng/ml", "GridLines": false, "Scaling": "Log" }, { "Type": "Y", "Dimension": "Concentration (mass)", "Unit": "ng/ml", "GridLines": false, "Scaling": "Log" } ], "GOFMergedPlotsResidualsOverTime": [ { "Type": "X", "Dimension": "Time", "Unit": "h", "GridLines": false, "Scaling": "Linear" }, { "Type": "Y", "Dimension": "Dimensionless", "Unit": "", "GridLines": false, "Scaling": "Linear" } ], "ComparisonTimeProfile": [ { "Type": "X", "Dimension": "Time", "Unit": "h", "GridLines": false, "Scaling": "Linear" }, { "Type": "Y", "Dimension": "Concentration (mass)", "Unit": "ng/ml", "GridLines": false, "Scaling": "Log" } ], "DDIRatioPlotsPredictedVsObserved": [ { "Type": "X", "Dimension": "Dimensionless", "Unit": "", "GridLines": false, "Scaling": "Log" }, { "Type": "Y", "Dimension": "Dimensionless", "Unit": "", "GridLines": false, "Scaling": "Log" } ], "DDIRatioPlotsResidualsVsObserved": [ { "Type": "X", "Dimension": "Dimensionless", "Unit": "", "GridLines": false, "Scaling": "Log" }, { "Type": "Y", "Dimension": "Dimensionless", "Unit": "", "GridLines": false, "Scaling": "Log" } ], "PKRatioPlots": [ { "Type": "X", "Dimension": "Age", "Unit": "year(s)", "GridLines": false, "Scaling": "Linear" }, { "Type": "Y", "Dimension": "Dimensionless", "Unit": "", "GridLines": false, "Scaling": "Log" } ] }, "PlotSettings": { "ChartWidth": 500, "ChartHeight": 400, "Fonts": { "AxisSize": 11, "LegendSize": 9, "OriginSize": 9, "FontFamilyName": "Arial", "WatermarkSize": 40 } }, "AllPlots": [], "GOFMergedPlots": [], "ComparisonTimeProfilePlots": [ { "SectionId": 304, "Title": "Kienlen 1993", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Alfentanil-DDI", "Simulation": "Kienlen 1993 - Alfentanil iv control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kienlen 1993 - Alfentanil control - Alfentanil - IV - 125 µg/kg - Serum - agg. (n=5)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Alfentanil-DDI", "Simulation": "Kienlen 1993 - Alfentanil iv + Cimetidine iv", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kienlen 1993 - Alfentanil + Cimetidine - Alfentanil - IV - 125 µg/kg - Serum - agg. (n=6)", "StartTime": 48, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 305, "Title": "Abernethy 1983", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Abernethy 1983 - Alprazolam 1 mg control", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Abernethy 1983 - Alprazolam control - Alprazolam - PO - 1 mg - Plasma - indiv.", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Abernethy 1983 - Alprazolam + Cimetidine - Alprazolam - PO - 1 mg - Plasma - indiv.", "StartTime": 12, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 305, "Title": "Pourbaix 1985", "SimulationDuration": 72, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Pourbaix 1985 - Alprazolam control - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=8)", "StartTime": 168, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Pourbaix 1985 - Alprazolam + Cimetidine - Alprazolam - PO - 0.5 mg - Plasma - agg. (n=8)", "StartTime": 336, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 307, "Title": "Greenblatt 1986 (midazolam IV)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam iv control", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1986 - 5 mg Midazolam IV control - Midazolam - IV - 5 mg - Plasma - indiv.", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1986 - 300 mg QD Cimetidine, 5 mg Midazolam IV - Midazolam - IV - 5 mg - Plasma - indiv.", "StartTime": 24, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 307, "Title": "Greenblatt 1986 (midazolam PO)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam po control", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1986 - 15 mg Midazolam PO control - Midazolam - PO - 15 mg - Plasma - indiv.", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1986 - 300 mg QD Cimetidine, 15 mg Midazolam PO - Midazolam - PO - 15 mg - Plasma - indiv.", "StartTime": 24, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 307, "Title": "Martinez 1999", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Martinez 1999, Midazolam po control", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Martinez 1999, Midazolam po + 800 mg cimetidine", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 307, "Title": "Fee 1987", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Fee 1987, Midazolam po control", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Fee 1987 - 15 mg Midazolam control - Midazolam - PO - 15 mg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Fee 1987, Midazolam po + 400 mg cimetidine BID", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Fee 1987 - 400 mg BID Cimetidine, 15 mg Midazolam - Midazolam - PO - 15 mg - Plasma - agg. (n=8)", "StartTime": 25, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 307, "Title": "Salonen 1986", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Salonen 1986, Midazolam po control", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Salonen 1986 - 15 mg Midazolam PO control - Midazolam - PO - 15 mg - Plasma - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Salonen 1986, Midazolam po + 400 mg cimetidine", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Salonen 1986 - 400 mg Cimetidine, 15 mg Midazolam - Midazolam - PO - 15 mg - Plasma - agg. (n=6)", "StartTime": 2, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 307, "Title": "Elliott 1984", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Elliott 1984, Midazolam po control", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Elliott 1984 - Midazolam/H2O - Midazolam - PO - 15 mg - Plasma - agg. (n=5)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Elliott 1984, Midazolam po + 200/400 mg cimetidine", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Elliott 1984 - Midazolam/cimetidine - Midazolam - PO - 15 mg - Plasma - agg. (n=5)", "StartTime": 26.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 308, "Title": "Abernethy 1983", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Abernethy 1983/Friedman 1988 - Triazolam control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Abernethy 1983 - Triazolam control - Triazolam - PO - 0.5 mg - Plasma - indiv.", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Abernethy 1983 - Triazolam + Cimetidine - Triazolam - PO - 0.5 mg - Plasma - indiv.", "StartTime": 12, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 308, "Title": "Friedman 1988", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Abernethy 1983/Friedman 1988 - Triazolam control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Friedman 1988 - Triazolam control - Triazolam - PO - 0.5 mg - Plasma - agg. (n=19)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Friedman 1988 - Triazolam + Cimetidine - Triazolam - PO - 0.5 mg - Plasma - agg. (n=19)", "StartTime": 24, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 308, "Title": "Pourbaix 1985", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Pourbaix 1985 - Triazolam control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Pourbaix 1985 - Triazolam control - Triazolam - PO - 0.5 mg - Plasma - agg. (n=8)", "StartTime": 144, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Pourbaix 1985 - Triazolam + Cimetidine - Triazolam - PO - 0.5 mg - Plasma - agg. (n=8)", "StartTime": 327, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 308, "Title": "Cox 1986", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Cox 1986 - Triazolam intraduodenal control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Cox 1986 - triazolam control - Triazolam - intraduodenal - 0.5 mg - Serum - agg. (n=4)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Cox 1986 - triazolam + cimetidine - Triazolam - intraduodenal - 0.5 mg - Serum - agg. (n=4)", "StartTime": 13, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 309, "Title": "Smith 1984 (verapamil IV)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 10 mg iv control", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Smith 1984 - IV 10 mg Verapamil control - Verapamil - IV - 10 mg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Smith 1984 - IV 10 mg Verapamil + Cimetidine - Verapamil - IV - 10 mg - Plasma - agg. (n=8)", "StartTime": 168, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 309, "Title": "Smith 1984 (verapamil PO)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 120 mg po control", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Smith 1984 - PO 120 mg Verapamil control - Verapamil - PO - 120 mg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Smith 1984 - PO 120 mg Verapamil + Cimetidine - Verapamil - PO - 120 mg - Plasma - agg. (n=8)", "StartTime": 168, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Cimetidine", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Gorski 1998 (midazolam IV)", "SimulationDuration": 14, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 0.05 mg/kg iv", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 1998 - iv Control (Perpetrator Placebo) - Midazolam - IV - 0.05 mg/kg - Whole Blood - agg. (n=16)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 1998 - iv with Perpetrator (Clarithromycin) - Midazolam - IV - 0.05 mg/kg - Whole Blood - agg. (n=16)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Gorski 1998 (midazolam po)", "SimulationDuration": 14, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 4 mg po", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 1998 - po Control (Perpetrator Placebo) - Midazolam - PO - 4 mg - Whole Blood - agg. (n=16)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 1998 - po with Perpetrator (Clarithromycin) - Midazolam - PO - 4 mg - Whole Blood - agg. (n=16)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Gurley 2006", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2006", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2006 - Control pre-Clarithromycin (Perpetrator Placebo) - Midazolam - PO - 8 mg - Plasma - agg. (n=19)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2006 - with Perpetrator (Clarithomycin) - Midazolam - PO - 8 mg - Plasma - agg. (n=19)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Gurley 2008a", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2008a", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2008a - Control pre-Clarithromycin (Perpetrator Placebo) - Midazolam - PO - 8 mg - Plasma - agg. (n=16)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2008a - with Perpetrator (Clarithomycin) - Midazolam - PO - 8 mg - Plasma - agg. (n=16)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Markert 2013", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Markert 2013, Midazolam 3 mg po", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Markert 2013 - Control (Perpetrator Placebo) - Midazolam - PO - 3 mg - Plasma - agg. (n=11)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Markert 2013 - with Perpetrator (Clarithromycin) - Midazolam - PO - 3 mg - Plasma - agg. (n=11)", "StartTime": 72.25, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Prueksaritanont 2017", "SimulationDuration": 48, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Prueksaritanont 2017", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Prueksaritanont 2017 - Midazolam in microdosecocktail alone - Midazolam - PO - 10 µg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Prueksaritanont 2017 - Midazolam in microdosecocktail + Clarithromycin - Midazolam - PO - 10 µg - Plasma - agg. (n=8)", "StartTime": 72, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Quinney 2008 (midazolam IV)", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - iv - Quinney 2008", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Quinney 2008 - Control iv Midazolam All - Midazolam - IV - 0.05 mg/kg - Whole Blood - agg. (n=16)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Quinney 2008 - iv Midazolam All after clarithromycin - Midazolam - IV - 0.05 mg/kg - Whole Blood - agg. (n=16)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Quinney 2008 (midazolam po)", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - po - Quinney 2008", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Quinney 2008 - Control po Midazolam All - Midazolam - PO - 3.0 - 4.0 mg - Whole Blood - agg. (n=16)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Quinney 2008 - po Midazolam All after clarithromycin - Midazolam - PO - 3.0 - 4.0 mg - Whole Blood - agg. (n=16)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "van Dyk 2018", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - van Dyk 2018", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "van Dyk 2018 - Midazolam in Caucasian at baseline - Midazolam - PO - 1 mg - Plasma - agg. (n=19)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 324, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 310, "Title": "Yeates 1996", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Yeates 1996, Midazolam 15 mg po", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yeates 1996 - Control (Perpetrator Placebo) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yeates 1996 - with Perpetrator (Clarithromycin) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "StartTime": 97.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 311, "Title": "Greenblatt 1998a", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Clarithromycin-Triazolam-DDI", "Simulation": "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1998a - Triazolam + Placebo (Trial B) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Clarithromycin)", "Symbol": "Circle" }, { "Project": "Clarithromycin-Triazolam-DDI", "Simulation": "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1998a - Triazolam + Clarithromycin (Trial E) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=12)", "StartTime": 25, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Clarithromycin", "Symbol": "Square" } ] }, { "SectionId": 315, "Title": "Bartkowski 1989", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Bartkowski 1989 - Control - Alfentanil - IV - 50 µg/kg - Serum - indiv.", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin) - Individual 1", "Symbol": "Circle" }, { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Perpetrator_Day1", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Bartkowski 1989 - Treatment Day 1 - Alfentanil - IV - 50 µg/kg - Serum - indiv.", "StartTime": 1.5, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment with erythromycin (Day 1) - Individual 1", "Symbol": "Triangle" }, { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Perpetrator_Day7", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Bartkowski 1989 - Treatment Day 7 - Alfentanil - IV - 50 µg/kg - Serum - indiv.", "StartTime": 145.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with erythromycin (Day 7) - Individual 1", "Symbol": "Square" } ] }, { "SectionId": 315, "Title": "Bartkowski 1993", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Bartkowski 1993 - Control - Alfentanil - IV - 50 µg/kg - Serum - indiv.", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin) - Individual 2", "Symbol": "Circle" }, { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Perpetrator_Day1", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Bartkowski 1993 - Treatment Day 1 - Alfentanil - IV - 50 µg/kg - Serum - indiv.", "StartTime": 1.5, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment with erythromycin (Day 1) - Individual 2", "Symbol": "Triangle" }, { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Perpetrator_Day7", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Bartkowski 1993 - Treatment Day 7 - Alfentanil - IV - 50 µg/kg - Serum - indiv.", "StartTime": 145.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with erythromycin (Day 7) - Individual 2", "Symbol": "Square" } ] }, { "SectionId": 316, "Title": "Yasui 1996", "SimulationDuration": 48, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Alprazolam-DDI", "Simulation": "Yasui1996_Control", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yasui 1996 - Treatment with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Alprazolam-DDI", "Simulation": "Yasui1996_Perpetrator", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yasui 1996 - Treatment with erythromycin - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=12)", "StartTime": 170, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with erythromycin", "Symbol": "Square" } ] }, { "SectionId": 318, "Title": "Carls 2014", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Carls2014", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Carls2014_250mg", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 1, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment with erythromycin (250 mg)", "Symbol": "Square" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Carls2014_1000mg", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 1, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with erythromycin (1000 mg)", "Symbol": "Triangle" } ] }, { "SectionId": 318, "Title": "Okudaira 2007", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Okudaira2007_EM0", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Okudaira 2007 - EM 0 Control (Perpetrator Placebo) - Midazolam - PO - 2.5 (actually 5) mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Okudaira2007_EM2", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Okudaira 2007 - EM 2 with Perpetrator (Erythromycin) - Midazolam - PO - 2.5 mg - Plasma - agg. (n=12)", "StartTime": 25, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with erythromycin for 2 days", "Symbol": "Square" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Okudaira2007_EM4", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Okudaira 2007 - EM 4 with Perpetrator (Erythromycin) - Midazolam - PO - 2.5 mg - Plasma - agg. (n=12)", "StartTime": 73, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment with erythromycin for 4 days", "Symbol": "Triangle" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Okudaira2007_EM7", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Okudaira 2007 - EM 7 with Perpetrator (Erythromycin) - Midazolam - PO - 2.5 mg - Plasma - agg. (n=12)", "StartTime": 145, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment with erythromycin for 7 days", "Symbol": "Diamond" } ] }, { "SectionId": 318, "Title": "Olkkola 1993 (midazolam IV)", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Olkkola1993_IV", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1993 - iv Control (Perpetrator Placebo) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Olkkola1993_IV", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1993 - iv with Perpetrator (Erythromycin) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=6)", "StartTime": 128, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with erythromycin)", "Symbol": "Square" } ] }, { "SectionId": 318, "Title": "Olkkola 1993 (midazolam po)", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Olkkola1993_Oral", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1993 - po Control (Perpetrator Placebo) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Olkkola1993_Oral", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1993 - po with Perpetrator (Erythromycin) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "StartTime": 128, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with erythromycin)", "Symbol": "Square" } ] }, { "SectionId": 318, "Title": "Swart 2002", "SimulationDuration": 6, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Swart2002", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Swart 2002 - day 5 Control (Perpetrator Placebo) - Midazolam - IV - 0.075 mg/kg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Swart2002", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Swart 2002 - day 10 Control with Perpetrator (Erythromycin) - Midazolam - IV - 0.075 mg/kg - Plasma - agg. (n=8)", "StartTime": 96, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with erythromycin)", "Symbol": "Square" } ] }, { "SectionId": 318, "Title": "Zimmermann 1996", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Zimmermann1996", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Zimmermann 1996 - Control (Perpetrator Placebo) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Zimmermann1996", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Zimmermann 1996 - with Perpetrator (Erythromycin) - Midazolam - PO - 15 mg - Plasma - agg. (n=12)", "StartTime": 97.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with erythromycin)", "Symbol": "Square" } ] }, { "SectionId": 319, "Title": "Greenblatt 1998", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Greenblatt1998_Control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1998a - Triazolam + Placebo (Trial B) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Greenblatt1998_Perpetrator", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Greenblatt 1998a - Triazolam + Erythromycin (Trial D) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=12)", "StartTime": 25, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with erythromycin", "Symbol": "Square" } ] }, { "SectionId": 319, "Title": "Phillips 1986", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Phillips1986_Control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Phillips 1986 - Triazolam alone - Triazolam - PO - 0.5 mg - Plasma - agg. (n=16)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without erythromycin)", "Symbol": "Circle" }, { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Phillips1986_Perpetrator", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Phillips 1986 - Triazolam after 3 days of erythromycin - Triazolam - PO - 0.5 mg - Plasma - agg. (n=16)", "StartTime": 64, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with erythromycin", "Symbol": "Square" } ] }, { "SectionId": 323, "Title": "Fleishaker 1994 (Day 1, first dose)", "SimulationDuration": 6, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Alprazolam", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Fleishaker 1994 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=20)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Fluvoxamine)", "Symbol": "Circle" }, { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Fluvoxamine_Alprazolam", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Fleishaker 1994 - Alprazolam + fluvoxamine - Alprazolam - PO - 1 mg - Plasma - agg. (n=20)", "StartTime": 144, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Fluvoxamine", "Symbol": "Square" } ] }, { "SectionId": 323, "Title": "Fleishaker 1994 (Day 10)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Alprazolam", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Fleishaker 1994 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=20)", "StartTime": 72, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Fluvoxamine)", "Symbol": "Circle" }, { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Fluvoxamine_Alprazolam", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Fleishaker 1994 - Alprazolam + fluvoxamine - Alprazolam - PO - 1 mg - Plasma - agg. (n=20)", "StartTime": 216, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Fluvoxamine", "Symbol": "Square" } ] }, { "SectionId": 324, "Title": "Kashuba 1998", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kashuba 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Fluvoxamine)", "Symbol": "Circle" }, { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 517, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Fluvoxamine)", "Symbol": "Square" } ] }, { "SectionId": 324, "Title": "Lam 2003", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "Lam 2003, 10 mg, SD, midazolam control", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lam 2003 - Midazolam before Fluvoxamine - Midazolam - PO - 10 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Fluvoxamine)", "Symbol": "Circle" }, { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lam 2003 - Midazolam after Fluvoxamine - Midazolam - PO - 10 mg - Plasma - agg. (n=10)", "StartTime": 265, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Fluvoxamine)", "Symbol": "Square" } ] }, { "SectionId": 325, "Title": "Yasui 1998", "SimulationDuration": 48, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Alprazolam-DDI", "Simulation": "Yasui 1998 - Alprazolam 0.8 mg with placebo", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yasui 1998 - Alprazolam with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Alprazolam-DDI", "Simulation": "Yasui 1998 - Alprazolam 0.8 mg with itraconazole", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yasui 1998 - Alprazolam with itraconazole - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=10)", "StartTime": 73, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 326, "Title": "Ahonen 1995", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Ahonen 1995", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Ahonen 1995 - Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Ahonen 1995 - with Perpetrator (Itraconazole) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 74, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 326, "Title": "Backman 1998", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1998 - Phase I (Control (Perpetrator Placebo)) - Midazolam - PO - 15 mg - Plasma - agg. (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1998 - Phase II (during Perpetrator (Itraconazole)) - Midazolam - PO - 15 (actually 7.5) mg - Plasma - agg. (n=9)", "StartTime": 74, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment Phase II (with Itraconazole)", "Symbol": "Square" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1998 - Phase III (4 days after Perpetrator (Itraconazole)) - Midazolam - PO - 15 (actually 7.5) mg - Plasma - agg. (n=9)", "StartTime": 170, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment Phase III (with Itraconazole)", "Symbol": "Triangle" } ] }, { "SectionId": 326, "Title": "Olkkola 1994", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1994", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1994 - po Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1994 - po with Perpetrator (Itraconazole) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=9)", "StartTime": 73, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 326, "Title": "Olkkola 1996 (day 1 po)", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 1 (po) Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 1 (po) with Perpetrator (Itraconazole) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 2, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 326, "Title": "Olkkola 1996 (day 4 iv)", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 4 (iv) Control (Perpetrator Placebo) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 4 (iv) with Perpetrator (Itraconazole) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=12)", "StartTime": 74, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 326, "Title": "Olkkola 1996 (day 6 po)", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 6 (po) Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 6 (po) with Perpetrator (Itraconazole) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 122, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 326, "Title": "Prueksaritanont 2017", "SimulationDuration": 72, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Prueksaritanont 2017", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Prueksaritanont 2017 - Midazolam in microdosecocktail alone - Midazolam - PO - 10 µg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Prueksaritanont 2017 - Midazolam in microdosecocktail + Itraconazole - Midazolam - PO - 10 µg - Plasma - agg. (n=8)", "StartTime": 72, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 326, "Title": "Templeton 2010", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Templeton 2010", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Templeton 2010 - Control (Perpetrator Placebo) - Midazolam - PO - 2 mg - Plasma - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Templeton 2010 - with Perpetrator (Itraconazole @ 50 mg) - Midazolam - PO - 2 mg - Plasma - agg. (n=6)", "StartTime": 4, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with 100 mg Itraconazole)", "Symbol": "Square" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Templeton 2010 - with Perpetrator (Itraconazole @ 200 mg) - Midazolam - PO - 2 mg - Plasma - agg. (n=6)", "StartTime": 4, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 200 mg Itraconazole)", "Symbol": "Triangle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Templeton 2010 - with Perpetrator (Itraconazole @ 400 mg) - Midazolam - PO - 2 mg - Plasma - agg. (n=6)", "StartTime": 4, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with 400 mg Itraconazole)", "Symbol": "Diamond" } ] }, { "SectionId": 326, "Title": "Yu 2004 (CYP3A5*3/*3)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yu 2004 - Control CYP3A5*3/*3 - Midazolam - IV - 1 mg - Plasma - agg. (n=7)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yu 2004 - Treatment Itraconazole CYP3A5*3/*3 - Midazolam - IV - 1 mg - Plasma - agg. (n=7)", "StartTime": 72, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 327, "Title": "Neuvonen 1996", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Neuvonen 1996 - Control phase (Triazolam without Itraconazole) - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Neuvonen 1996 - Treatment phase (triazolam + ITZ simultaneously) - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Treatment (Itraconazole administered simultaneously)", "Symbol": "Square" }, { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Neuvonen 1996 - Treatment phase (triazolam + ITZ 3 hr before) - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)", "StartTime": 3, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (Itraconazole administered 3h before)", "Symbol": "Triangle" }, { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Neuvonen 1996 - Treatment phase (triazolam + ITZ 12 hr before) - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)", "StartTime": 12, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (Itraconazole administered 12h before)", "Symbol": "Diamond" }, { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Neuvonen 1996 - Treatment phase (triazolam + ITZ 24 hr before) - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)", "StartTime": 24, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (Itraconazole administered 24h before)", "Symbol": "Asterisk" } ] }, { "SectionId": 327, "Title": "Varhe 1994", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Varhe 1994 - Triazolam 0.25 mg control", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Varhe 1994 - Triazolam with placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Itraconazole)", "Symbol": "Circle" }, { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Varhe 1994 - Triazolam with Itraconazole - Triazolam - PO - 0.25 mg - Plasma - agg. (n=9)", "StartTime": 73, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Itraconazole)", "Symbol": "Square" } ] }, { "SectionId": 333, "Title": "Backman 1994", "SimulationDuration": 20, "TimeUnit": "h", "OutputMappings": [ { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1994", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1994 - Midazolam with placebo - Midazolam - PO - 15 mg - Plasma - agg. (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Verapamil)", "Symbol": "Circle" }, { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Treatment - Verapamil/Midazolam - Backman 1994", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1994 - Midazolam with verapamil - Midazolam - PO - 15 mg - Plasma - agg. (n=9)", "StartTime": 25, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Verapamil)", "Symbol": "Square" } ] }, { "SectionId": 333, "Title": "Wang 2005 (iv)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Wang 2005", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Verapamil)", "Symbol": "Circle" }, { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Treatment - Verapamil/Midazolam - Wang 2005", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 168, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Verapamil)", "Symbol": "Square" } ] }, { "SectionId": 333, "Title": "Wang 2005 (po)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Wang 2005", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 24, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Verapamil)", "Symbol": "Circle" }, { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Treatment - Verapamil/Midazolam - Wang 2005", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 192, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Verapamil)", "Symbol": "Square" } ] }, { "SectionId": 312, "Title": "Kharasch 2012 IV", "SimulationDuration": 7.5, "TimeUnit": "h", "OutputMappings": [ { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil IV alone", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2012 - Alfentanil IV alone - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Efavirenz)", "Symbol": "Circle" }, { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2012 - Alfentanil IV + efavirenz - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "StartTime": 360.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Efavirenz", "Symbol": "Square" } ] }, { "SectionId": 312, "Title": "Kharasch 2012 PO", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil PO alone", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2012 - Alfentanil PO alone - Alfentanil - PO - 43 µg/kg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Efavirenz)", "Symbol": "Circle" }, { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2012 - Alfentanil PO + efavirenz - Alfentanil - PO - 43 µg/kg - Plasma - agg. (n=12)", "StartTime": 336.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Efavirenz", "Symbol": "Square" } ] }, { "SectionId": 314, "Title": "Mikus 2017 IV", "SimulationDuration": 9, "TimeUnit": "h", "OutputMappings": [ { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Mikus 2017 - Midazolam control IV - Midazolam - IV - 2 mg - Plasma - agg. (n=12)", "StartTime": 6, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Efavirenz)", "Symbol": "Circle" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Mikus 2017 - Efavirenz + Midazolam IV day 1 - Midazolam - IV - 2 mg - Plasma - agg. (n=12)", "StartTime": 18, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Efavirenz), Day 1", "Symbol": "Square" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 138, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with Efavirenz), Day 6", "Symbol": "Triangle" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 258, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with Efavirenz), Day 11", "Symbol": "Diamond" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 378, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Treatment (with Efavirenz), Day 16", "Symbol": "Asterisk" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 522, "TimeUnit": "h", "Color": "#f0b7b2", "Caption": "Treatment (with Efavirenz), Day 22", "Symbol": "" } ] }, { "SectionId": 314, "Title": "Mikus 2017 PO", "SimulationDuration": 8, "TimeUnit": "h", "OutputMappings": [ { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Mikus 2017 - Midazolam control PO - Midazolam - PO - 4 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Efavirenz)", "Symbol": "Circle" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Mikus 2017 - Efavirenz + Midazolam PO day 1 - Midazolam - PO - 4 mg - Plasma - agg. (n=12)", "StartTime": 12, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Efavirenz", "Symbol": "Square" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 132, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with Efavirenz), Day 6", "Symbol": "Triangle" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 252, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with Efavirenz), Day 11", "Symbol": "Diamond" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 372, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Treatment (with Efavirenz), Day 16", "Symbol": "Asterisk" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 516, "TimeUnit": "h", "Color": "#f0b7b2", "Caption": "Treatment (with Efavirenz), Day 22", "Symbol": "Cross" } ] }, { "SectionId": 314, "Title": "Katzenmaier 2010", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Katzenmaier 2010, Midazolam alone", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Katzenmaier 2010 - Midazolam control - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Efavirenz)", "Symbol": "Circle" }, { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Katzenmaier 2010 - Midazolam + Efavirenz - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "StartTime": 336, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Efavirenz", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Kharasch 1997", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 1997 20 µg/kg IV - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 1997 - Control (Perpetrator Placebo) - Alfentanil - IV - 20 µg/kg - Plasma - agg. (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 1997 20 µg/kg IV and Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 1997 - with Perpetrator (Rifampicin) - Alfentanil - IV - 20 µg/kg - Plasma - agg. (n=9)", "StartTime": 120.5, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Kharasch 2004 (iv)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 15 µg/kg IV - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - iv Control (Perpetrator Placebo) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 15 µg/kg IV and Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - iv with Perpetrator (Rifampicin) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=10)", "StartTime": 105, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Kharasch 2004 (po)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 60 µg/kg PO - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - po #1 (60 µg/kg) Control (Perpetrator Placebo) - Alfentanil - PO - 60 µg/kg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 60 µg/kg PO and Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - po #1 (60 µg/kg) with Perpetrator (Rifampicin) - Alfentanil - PO - 60 µg/kg - Plasma - agg. (n=10)", "StartTime": 129, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Kharasch 2011 (iv)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv Control (Perpetrator Placebo) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 5 mg) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "StartTime": 109, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 5 mg Rifampicin)", "Symbol": "Square" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 10 mg) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "StartTime": 109, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with 10 mg Rifampicin)", "Symbol": "Triangle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 25 mg) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "StartTime": 109, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 25 mg Rifampicin)", "Symbol": "Diamond" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 75 mg) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=12)", "StartTime": 109, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with 75 mg Rifampicin)", "Symbol": "Asterisk" } ] }, { "SectionId": 328, "Title": "Kharasch 2011 (po)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po Control (Perpetrator Placebo) - Alfentanil - PO - 75 µg/kg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 5 mg) - Alfentanil - PO - 75 µg/kg - Plasma - agg. (n=12)", "StartTime": 133, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Treatment (with 5 mg Rifampicin)", "Symbol": "Square" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 10 mg) - Alfentanil - PO - 75 µg/kg - Plasma - agg. (n=12)", "StartTime": 133, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with 10 mg Rifampicin)", "Symbol": "Triangle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 25 mg) - Alfentanil - PO - 75 µg/kg - Plasma - agg. (n=12)", "StartTime": 133, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 25 mg Rifampicin)", "Symbol": "Diamond" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 75 mg) - Alfentanil - PO - 75 µg/kg - Plasma - agg. (n=12)", "StartTime": 133, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with 75 mg Rifampicin)", "Symbol": "Asterisk" } ] }, { "SectionId": 328, "Title": "Kharasch 2011b (iv during sequential administration of iv unlabeled alfentanil and oral deuterated alfentanil)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b IV 1mg - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil IV Control sequential - Alfentanil - IV - 1 mg - Plasma - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil IV Rifampin coadmin sequential - Alfentanil - IV - 1 mg - Plasma - agg. (n=6)", "StartTime": 108, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Kharasch 2011b (iv during simultaneous administration of iv unlabeled alfentanil and oral deuterated alfentanil)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b IV 1mg - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil IV Control simultaneous - Alfentanil - IV - 1 mg - Plasma - agg. (n=6)", "StartTime": 24, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil IV Rifampin coadmin simultaneous - Alfentanil - IV - 1 mg - Plasma - agg. (n=6)", "StartTime": 132, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Kharasch 2011b (po during sequential administration of iv unlabeled alfentanil and oral deuterated alfentanil)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b PO 4mg - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil PO Control sequential - Alfentanil - PO - 4 mg - Plasma - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil PO Rifampin coadmin sequential - Alfentanil - PO - 4 mg - Plasma - agg. (n=6)", "StartTime": 111, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Kharasch 2011b (po during simultaneous administration of iv unlabeled alfentanil and oral deuterated alfentanil)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b PO 4mg - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil PO Control simultaneous - Alfentanil - PO - 4 mg - Plasma - agg. (n=6)", "StartTime": 21, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011b - Alfentanil PO Rifampin coadmin simultaneous - Alfentanil - PO - 4 mg - Plasma - agg. (n=6)", "StartTime": 132, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 328, "Title": "Phimmasone 2001", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Phimmasone 2001 15 µg/kg IV - control", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Phimmasone 2001 - Control (Perpetrator Placebo) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Phimmasone 2001 - with Perpetrator (Rifampicin) - Alfentanil - IV - 15 µg/kg - Plasma - agg. (n=6)", "StartTime": 107, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 329, "Title": "Gashaw 2003 (Day 7)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam control", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gashaw 2003 - Alprazolam 10h concentration before Rifampin treatment (control conditions, day 2) - Alprazolam - PO - 1 mg - Plasma - agg. (n=96)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam + Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gashaw 2003 - Alprazolam 10h concentration after Rifampin treatment (5 day rifampin treatment, day 7) - Alprazolam - PO - 1 mg - Plasma - agg. (n=96)", "StartTime": 100, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Rifampicin", "Symbol": "Square" } ] }, { "SectionId": 329, "Title": "Gashaw 2003 (after washout phase)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam control", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gashaw 2003 - Alprazolam 10h concentration before Rifampin treatment (control conditions, day 2) - Alprazolam - PO - 1 mg - Plasma - agg. (n=96)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam + Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gashaw 2003 - Alprazolam 10h concentration after wash out (day 22) - Alprazolam - PO - 1 mg - Plasma - agg. (n=96)", "StartTime": 436, "TimeUnit": "h", "Color": "#b2182b", "Caption": "After rifampicin washout phase", "Symbol": "Square" } ] }, { "SectionId": 329, "Title": "Schmider 1999", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Schmider 1999 - Alprazolam control", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Schmider 1999 - Alprazolam alone - Alprazolam - PO - 1 mg - Plasma - agg. (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Schmider 1999 - Alprazolam + Rifampicin", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Schmider 1999 - Alprazolam + Rifampin - Alprazolam - PO - 1 mg - Plasma - agg. (n=4 (17))", "StartTime": 96, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Rifampicin", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Backman 1996", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1996", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1996 - Control (Perpetrator Placebo) - Midazolam - PO - 15 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1996 - with Perpetrator (Rifampicin) - Midazolam - PO - 15 mg - Plasma - agg. (n=10)", "StartTime": 113, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Backman 1998 (Phase IV and V vs. I)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1998 - Phase I (Control (Perpetrator Placebo)) - Midazolam - PO - 15 mg - Plasma - agg. (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1998 - Phase IV (during Perpetrator (Rifampicin)) - Midazolam - PO - 15 mg - Plasma - agg. (n=9)", "StartTime": 113, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment Phase IV (with Rifampicin)", "Symbol": "Square" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Backman 1998 - Phase V (4 days after Perpetrator (Rifampicin)) - Midazolam - PO - 15 mg - Plasma - agg. (n=9)", "StartTime": 185, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment Phase V (with Rifampicin)", "Symbol": "Diamond" } ] }, { "SectionId": 330, "Title": "Björkhem-Bergman 2013", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Björkhem-Bergman 2013", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 336, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with 10 mg Rifampicin)", "Symbol": "Diamond" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 336, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 20 mg Rifampicin)", "Symbol": "Triangle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 336, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with 100 mg Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Chattopadhyay 2018", "SimulationDuration": 25, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Chattopadhyay 2018", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Chattopadhyay 2018 - Control (without Rifampicin) - Midazolam - PO - 1 mg - Plasma - agg. (n=11)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Chattopadhyay 2018 - with Perpetrator (Rifampicin) - Midazolam - PO - 1 mg - Plasma - agg. (n=11)", "StartTime": 168, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Chung 2006", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Chung 2006", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Chung 2006 - Control (Perpetrator Placebo) - Midazolam - PO - 0.075 mg/kg - Plasma - agg. (n=18)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Chung 2006 - with Perpetrator (Rifampicin) - Midazolam - PO - 0.075 mg/kg - Plasma - agg. (n=18)", "StartTime": 166, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Eap 2004 (7.5 mg)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Eap 2004 - 7.5 mg Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=13)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Eap 2004 - 7.5 mg with Perpetrator (Rifampicin) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=4)", "StartTime": 114, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Gorski 2003 (iv)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gorski 2003 (iv)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 2003 - iv Control (Perpetrator Placebo) - Midazolam - IV - 0.05 mg/kg - Whole Blood - agg. (n=52)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 2003 - iv with Perpetrator (Rifampicin) - Midazolam - IV - 0.05 mg/kg - Whole Blood - agg. (n=52)", "StartTime": 132, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Gorski 2003 (po)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gorski 2003 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 2003 - po Control (Perpetrator Placebo) - Midazolam - PO - 4 mg - Whole Blood - agg. (n=52)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "Gorski 2003 - po with Perpetrator (Rifampicin) - Midazolam - PO - 6 mg - Whole Blood - agg. (n=52)", "StartTime": 132, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Gurley 2006", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2006", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2006 - Control pre-Rifampicin (Perpetrator Placebo) - Midazolam - PO - 8 mg - Plasma - agg. (n=19)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2006 - with Perpetrator (Rifampicin) - Midazolam - PO - 8 mg - Plasma - agg. (n=19)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Gurley 2008a", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2008", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2008a - Control pre-Rifampicin (Perpetrator Placebo) - Midazolam - PO - 8 mg - Plasma - agg. (n=16)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Gurley 2008a - with Perpetrator (Rifampicin) - Midazolam - PO - 8 mg - Plasma - agg. (n=16)", "StartTime": 146, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Kharasch 1997", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 1997", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 1997 - Control (Perpetrator Placebo) - Midazolam - IV - 1 mg - Plasma - typical (n=9)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 1997 - with Perpetrator (Rifampicin) - Midazolam - IV - 1 mg - Plasma - typical (n=9)", "StartTime": 120, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Kharasch 2004 (iv)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2004 (iv)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - iv Control (Perpetrator Placebo) - Midazolam - IV - 1 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - iv with Perpetrator (Rifampicin) - Midazolam - IV - 1 mg - Plasma - agg. (n=10)", "StartTime": 104, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Kharasch 2004 (po)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2004 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - po #1 Control (Perpetrator Placebo) - Midazolam - PO - 3 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2004 - po #1 with Perpetrator (Rifampicin) - Midazolam - PO - 3 mg - Plasma - agg. (n=10)", "StartTime": 128, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Kharasch 2011 (iv)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (iv)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv Control (Perpetrator Placebo) - Midazolam - IV - 1 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 5 mg) - Midazolam - IV - 1 mg - Plasma - agg. (n=12)", "StartTime": 108, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Treatment (with 5 mg Rifampicin)", "Symbol": "Square" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 10 mg) - Midazolam - IV - 1 mg - Plasma - agg. (n=12)", "StartTime": 108, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with 10 mg Rifampicin)", "Symbol": "Triangle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 25 mg) - Midazolam - IV - 1 mg - Plasma - agg. (n=12)", "StartTime": 108, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 25 mg Rifampicin)", "Symbol": "Diamond" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - iv with Perpetrator (Rifampicin @ 75 mg) - Midazolam - IV - 1 mg - Plasma - agg. (n=12)", "StartTime": 108, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with 75 mg Rifampicin)", "Symbol": "Asterisk" } ] }, { "SectionId": 330, "Title": "Kharasch 2011 (po)", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po Control (Perpetrator Placebo) - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 5 mg) - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "StartTime": 132, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Treatment (with 5 mg Rifampicin)", "Symbol": "Square" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 10 mg) - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "StartTime": 132, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with 10 mg Rifampicin)", "Symbol": "Triangle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 25 mg) - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "StartTime": 132, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 25 mg Rifampicin)", "Symbol": "Diamond" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kharasch 2011 - po with Perpetrator (Rifampicin @ 75 mg) - Midazolam - PO - 3 mg - Plasma - agg. (n=12)", "StartTime": 132, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with 75 mg Rifampicin)", "Symbol": "Asterisk" } ] }, { "SectionId": 330, "Title": "Kim 2018", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kim 2018 (male)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 216, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Link 2008 (iv)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Link 2008 (iv)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Link 2008 - iv Control (Perpetrator Placebo) - Midazolam - IV - 2 mg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Link 2008 - iv with Perpetrator (Rifampicin) - Midazolam - IV - 2 mg - Plasma - agg. (n=8)", "StartTime": 144, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Link 2008 (po)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Link 2008 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Link 2008 - po Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Link 2008 - po with Perpetrator (Rifampicin) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=8)", "StartTime": 144, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Lutz 2008", "SimulationDuration": 14, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Lutz 2018 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lutz 2018 - Cohort 1, Control - Midazolam - PO - 2 mg - Plasma - agg. (n=20)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control Cohort 1 (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Lutz 2018 (po)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lutz 2018 - Cohort 2, Control - Midazolam - PO - 2 mg - Plasma - agg. (n=20)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control Cohort 2 (without Rifampicin)", "Symbol": "Square" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lutz 2018 - Cohort 2, 2 mg Rifampicin - Midazolam - PO - 2 mg - Plasma - agg. (n=20)", "StartTime": 228, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Treatment Cohort 2 (2 mg Rifampicin)", "Symbol": "Cross" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lutz 2018 - Cohort 1, 10 mg Rifampicin - Midazolam - PO - 2 mg - Plasma - agg. (n=20)", "StartTime": 228, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment Cohort 1 (10 mg Rifampicin)", "Symbol": "Asterisk" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lutz 2018 - Cohort 1, 75 mg Rifampicin - Midazolam - PO - 2 mg - Plasma - agg. (n=20)", "StartTime": 660, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment Cohort 1 (10 mg Rifampicin)", "Symbol": "Diamond" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Lutz 2018 - Cohort 2, 600 mg Rifampicin - Midazolam - PO - 2 mg - Plasma - agg. (n=20)", "StartTime": 660, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment Cohort 2 (2 mg Rifampicin)", "Symbol": "Triangle" } ] }, { "SectionId": 330, "Title": "Phimmasone 2001", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Phimmasone 2001", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Phimmasone 2001 - Control (Perpetrator Placebo) - Midazolam - IV - 1 mg - Plasma - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Phimmasone 2001 - with Perpetrator (Rifampicin) - Midazolam - IV - 1 mg - Plasma - agg. (n=6)", "StartTime": 106, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Prueksaritanont 2017", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Prueksaritanont 2017", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Prueksaritanont 2017 - Midazolam in microdosecocktail alone - Midazolam - PO - 10 µg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Prueksaritanont 2017 - Midazolam in microdosecocktail + Rifampin - Midazolam - PO - 10 µg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Reitman 2011", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Reitman 2011 - Week 0 after Perpetrator (Rifampicin) - Midazolam - PO - 2 mg - Plasma - agg. (n=11)", "StartTime": 648, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Week 0 after treatment with rifampicin", "Symbol": "Square" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Reitman 2011 - Week 1 after Perpetrator (Rifampicin) - Midazolam - PO - 2 mg - Plasma - agg. (n=11)", "StartTime": 816, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Week 1 after treatment with rifampicin", "Symbol": "Triangle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Reitman 2011 - Week 2 after Perpetrator (Rifampicin) - Midazolam - PO - 2 mg - Plasma - agg. (n=11)", "StartTime": 984, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Week 2 after treatment with rifampicin", "Symbol": "Diamond" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Reitman 2011 - Week 4 after Perpetrator (Rifampicin) - Midazolam - PO - 2 mg - Plasma - agg. (n=11)", "StartTime": 1320, "TimeUnit": "h", "Color": "#e4948e", "Caption": "Week 4 after treatment with rifampicin", "Symbol": "Circle" } ] }, { "SectionId": 330, "Title": "Shin 2013", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Shin 2013", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Shin 2013 - Control phase (Midazolam alone) - Midazolam - IV - 1 mg - Plasma - agg. (n=24)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Shin 2013 - CYP3A4 induced phase (Midazolam + rifampicin) - Midazolam - IV - 2.5 mg - Plasma - agg. (n=24)", "StartTime": 216, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Shin 2016", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Shin 2016", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Shin 2016 - Midazolam alone - Midazolam - IV - 1 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Shin 2016 - Midazolam + rifampicin - Midazolam - IV - 2.5 mg - Plasma - agg. (n=12)", "StartTime": 216, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Szalat 2007", "SimulationDuration": 6, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Szalat 2007", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Szalat 2007 - Control (Perpetrator Placebo) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=3)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Szalat 2007 - with Perpetrator (Rifampicin) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=3)", "StartTime": 132, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "van Dyk 2018", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - van Dyk 2018", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "van Dyk 2018 - Midazolam in Caucasian at baseline - Midazolam - PO - 1 mg - Plasma - agg. (n=19)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 156, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Wiesinger 2020", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Wiesinger 2020", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Wiesinger 2020 - Control phase (no RIF) - Midazolam - PO - 1 mg - Plasma - agg. (n=65)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Wiesinger 2020 - Weak-induction phase (RIF 10 mg) - Midazolam - PO - 1 mg - Plasma - agg. (n=65)", "StartTime": 180, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (low dose 10 mg Rifampicin)", "Symbol": "Triangle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Wiesinger 2020 - Strong-induction phase (RIF 600 mg) - Midazolam - PO - 1 mg - Plasma - agg. (n=65)", "StartTime": 444, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (high dose 600 mg Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 330, "Title": "Yu 2004 (CYP3A5*3/*3)", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yu 2004 - Control CYP3A5*3/*3 - Midazolam - IV - 1 mg - Plasma - agg. (n=7)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Yu 2004 - Treatment Rifampicin CYP3A5*3/*3 - Midazolam - IV - 2 mg - Plasma - agg. (n=7)", "StartTime": 240, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with Rifampicin)", "Symbol": "Square" } ] }, { "SectionId": 331, "Title": "Villikka 1997", "SimulationDuration": 12, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Triazolam-DDI", "Simulation": "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Villikka 1997 - Triazolam + placebo - Triazolam - PO - 0.5 mg - Plasma - agg. (n=10)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Triazolam-DDI", "Simulation": "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Villikka 1997 - Treatment arm (pretreatment with rifampin; 600 mg; 5 days) - Triazolam - PO - 0.5 mg - Plasma - agg. (n=10)", "StartTime": 113, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Rifampicin", "Symbol": "Square" } ] }, { "SectionId": 332, "Title": "Barbarash 1988 (verapamil IV)", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Control - Verapamil - Barbarash 1988 (iv)", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbarash 1988 - Verapamil IV control - Verapamil - IV - 10 mg - Serum - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbarash 1988 - Verapamil IV after 2 weeks of Rifampicin therapy - Verapamil - IV - 10 mg - Serum - agg. (n=6)", "StartTime": 300, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Rifampicin", "Symbol": "Square" } ] }, { "SectionId": 332, "Title": "Barbarash 1988 (verapamil PO)", "SimulationDuration": 15, "TimeUnit": "h", "OutputMappings": [ { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Control - Verapamil - Barbarash 1988 (po)", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbarash 1988 - Verapamil PO control - Verapamil - PO - 120 mg - Serum - agg. (n=6)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without Rifampicin)", "Symbol": "Circle" }, { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)", "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "Barbarash 1988 - Verapamil PO after 2 weeks of Rifampicin therapy - Verapamil - PO - 120 mg - Serum - agg. (n=6)", "StartTime": 348, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment with Rifampicin", "Symbol": "Square" } ] }, { "SectionId": 320, "Title": "Palkama 1998", "SimulationDuration": 10, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluconazole-Alfentanil-DDI", "Simulation": "Alfentanil placebo", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Palkama 1998 - Alfentanil placebo - Alfentanil - IV - 20 µg/kg - Plasma - agg. (n=9)", "StartTime": 1, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without fluconazole)", "Symbol": "Circle" }, { "Project": "Fluconazole-Alfentanil-DDI", "Simulation": "Alfentanil -Fluconzole i.v. DDI", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Palkama 1998 - Alfentanil with perpetrator fluconazole i.v. - Alfentanil - IV - 20 µg/kg - Plasma - agg. (n=9)", "StartTime": 1, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with intravenous fluconazole)", "Symbol": "Square" }, { "Project": "Fluconazole-Alfentanil-DDI", "Simulation": "Alfentanil -Fluconzole oral. DDI", "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "Palkama 1998 - Alfentanil with perpetrator fluconazole po - Alfentanil - IV - 20 µg/kg - Plasma - agg. (n=9)", "StartTime": 1, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with oral fluconazole)", "Symbol": "Triangle" } ] }, { "SectionId": 321, "Title": "Ahonen 1997", "SimulationDuration": 17, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Ahonen_midazolam_po_7.5mg_placebo", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Ahonen 1997 - Midazolam placebo - Midazolam - PO - 7.5 mg - Plasma - agg. (n=9)", "StartTime": 1, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without fluconazole)", "Symbol": "Circle" }, { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Ahonen 1997 - Midazolam with perpetrator fluconazole i.v - Midazolam - PO - 7.5 mg - Plasma - agg. (n=9)", "StartTime": 1, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with intravenous fluconazole)", "Symbol": "Square" }, { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Ahonen 1997 - Midazolam with perpetrator fluconazole oral - Midazolam - PO - 7.5 mg - Plasma - agg. (n=9)", "StartTime": 1, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with oral fluconazole)", "Symbol": "Triangle" } ] }, { "SectionId": 321, "Title": "Olkkola 1996 Day 1", "SimulationDuration": 7, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_placebo_day 1", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 1 (po) Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without fluconazole)", "Symbol": "Circle" }, { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_fluconazole_DDI_day 1", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 1 (po) with Perpetrator (Fluconazole) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 2, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with fluconazole)", "Symbol": "Square" } ] }, { "SectionId": 321, "Title": "Olkkola 1996 Day 4", "SimulationDuration": 7, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_placebo_day 4", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 4 (iv) Control (Perpetrator Placebo) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without fluconazole)", "Symbol": "Circle" }, { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_fluconazole_DDI_day 4", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 4 (iv) with Perpetrator (Fluconazole) - Midazolam - IV - 0.05 mg/kg - Plasma - agg. (n=12)", "StartTime": 74, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with fluconazole)", "Symbol": "Square" } ] }, { "SectionId": 321, "Title": "Olkkola 1996 Day 6", "SimulationDuration": 17, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_placebo_day 6", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 6 (po) Control (Perpetrator Placebo) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without fluconazole)", "Symbol": "Circle" }, { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_fluconazole_DDI_day 6", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Olkkola 1996 - day 6 (po) with Perpetrator (Fluconazole) - Midazolam - PO - 7.5 mg - Plasma - agg. (n=12)", "StartTime": 122, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with fluconazole)", "Symbol": "Square" } ] }, { "SectionId": 322, "Title": "Varhe 1996c", "SimulationDuration": 18, "TimeUnit": "h", "OutputMappings": [ { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po placebo", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Varhe 1996c - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without fluconazole)", "Symbol": "Circle" }, { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po fluconazole 50mg", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Varhe 1996c - Triazolam with perpetrator fluconazole 50mg - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)", "StartTime": 73, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with 50 mg fluconazole)", "Symbol": "Square" }, { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po fluconazole 100mg", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Varhe 1996c - Triazolam with perpetrator fluconazole 100mg - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)", "StartTime": 73, "TimeUnit": "h", "Color": "#c54a4a", "Caption": "Treatment (with 100 mg fluconazole)", "Symbol": "Triangle" }, { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po fluconazole 200mg", "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Varhe 1996c - Triazolam with perpetrator fluconazole 200mg - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)", "StartTime": 73, "TimeUnit": "h", "Color": "#d6706b", "Caption": "Treatment (with 200 mg fluconazole)", "Symbol": "Diamond" } ] }, { "SectionId": 301, "Title": "Furukori 1998", "SimulationDuration": 48, "TimeUnit": "h", "OutputMappings": [ { "Project": "Carbamazepine-Alprazolam-DDI", "Simulation": "Furukori1998_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Furukori 1998 - treatment with placebo - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=7)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Carbamazepine-Alprazolam-DDI", "Simulation": "Furukori1998_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Furukori 1998 - treatment with carbamazepine - Alprazolam - PO - 0.8 mg - Plasma - agg. (n=7)", "StartTime": 170, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 303, "Title": "Kanefendt 2023 (Study 1)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study1_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanefendt 2023 - Study 1, midazolam alone - Midazolam - PO - 1 mg - Plasma - agg. (n=14)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study1_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanefendt 2023 - Study 1, midazolam after pretreatment with carbamazepine - Midazolam - PO - 1 mg - Plasma - agg. (n=14)", "StartTime": 334, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 303, "Title": "Kanefendt 2023 (Study 2)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study2_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanefendt 2023 - Study 2, midazolam alone - Midazolam - PO - 1 mg - Plasma - agg. (n=13)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study2_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "Kanefendt 2023 - Study 2, midazolam after pretreatment with carbamazepine - Midazolam - PO - 1 mg - Plasma - agg. (n=13)", "StartTime": 336, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 303, "Title": "Lutz 2018", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Lutz2018_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Lutz2018_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 576, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 302, "Title": "Ji 2008 (Arm 1, Perpetrator: Carbamazepine, Victim: Efavirenz)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Carbamazepine-Efavirenz-DDI", "Simulation": "Ji2008_Arm1_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Efavirenz|Plasma (Peripheral Venous Blood)", "ObservedData": "Ji 2008 - Efavirenz, control (Arm 1) - Efavirenz - PO - 600 mg - Plasma - agg. (n=14)", "StartTime": 312, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Carbamazepine-Efavirenz-DDI", "Simulation": "Ji2008_Arm1_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Efavirenz|Plasma (Peripheral Venous Blood)", "ObservedData": "Ji 2008 - Efavirenz + Carbamazepine, treatment (Arm 1) - Efavirenz - PO - 600 mg - Plasma - agg. (n=14)", "StartTime": 816, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 317, "Title": "Barzaghi 1987", "SimulationDuration": 96, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Barzaghi1987_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Barzaghi1987_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)", "StartTime": 144, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 317, "Title": "Wong 1983", "SimulationDuration": 72, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Wong1983_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Wong1983_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.", "StartTime": 120, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 317, "Title": "Miles 1989 (average dose of 357 mg)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_ControlPhase_357mg", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)", "StartTime": 312, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_TreatmentPhase_357mg", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)", "StartTime": 384, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 317, "Title": "Miles 1989 (300 mg)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_ControlPhase_300mg", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 312, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_TreatmentPhase_300mg", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 384, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 317, "Title": "Miles 1989 (400 mg)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_ControlPhase_400mg", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 312, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without carbamazepine)", "Symbol": "Circle" }, { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_TreatmentPhase_400mg", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 384, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with carbamazepine)", "Symbol": "Square" } ] }, { "SectionId": 306, "Title": "Dalton 1985a", "SimulationDuration": 154, "TimeUnit": "h", "OutputMappings": [ { "Project": "Cimetidine-Carbamazepine-DDI", "Simulation": "Dalton1985a_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)", "StartTime": 0, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without cimetidine)", "Symbol": "Circle" }, { "Project": "Cimetidine-Carbamazepine-DDI", "Simulation": "Dalton1985a_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": [], "StartTime": 47, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with cimetidine)", "Symbol": "Square" } ] }, { "SectionId": 313, "Title": "Ji 2008 (Arm 2, Perpetrator: Efavirenz, Victim: Carbamazepine)", "SimulationDuration": 24, "TimeUnit": "h", "OutputMappings": [ { "Project": "Efavirenz-Carbamazepine-DDI", "Simulation": "Ji2008_Arm2_ControlPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Ji 2008 - Carbamazepine, control (Arm 2) - Carbamazepine - PO - 200 / 400 mg - Plasma - agg. (n=36)", "StartTime": 480, "TimeUnit": "h", "Color": "#2166ac", "Caption": "Control (without efavirenz)", "Symbol": "Circle" }, { "Project": "Efavirenz-Carbamazepine-DDI", "Simulation": "Ji2008_Arm2_TreatmentPhase", "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "Ji 2008 - Carbamazepine + Efavirenz, treatment (Arm 2) - Carbamazepine - PO - 200 / 400 mg - Plasma - agg. (n=36)", "StartTime": 816, "TimeUnit": "h", "Color": "#b2182b", "Caption": "Treatment (with efavirenz)", "Symbol": "Square" } ] } ], "DDIRatioPlots": [ { "SectionId": 2, "Title": "CYP3A4 DDI", "PKParameter": "AUC|CMAX", "PlotType": "predictedVsObserved|residualsVsObserved", "Artifacts": [ "Plot", "GMFE", "Measure", "Table" ], "Groups": [ { "Caption": "Cimetidine + Alfentanil (iv)", "Color": "#FF0000", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1344, "SimulationControl": { "Project": "Cimetidine-Alfentanil-DDI", "Simulation": "Kienlen 1993 - Alfentanil iv control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Alfentanil-DDI", "Simulation": "Kienlen 1993 - Alfentanil iv + Cimetidine iv", "StartTime": 48, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Cimetidine + Alprazolam (po)", "Color": "#0000FF", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1332, "SimulationControl": { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Abernethy 1983 - Alprazolam 1 mg control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Abernethy 1983 - Alprazolam 1 mg + 300 mg cimetidine QID", "StartTime": 12, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1340, "SimulationControl": { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Pourbaix 1985 - Alprazolam 0.5 mg TID control", "StartTime": 168, "EndTime": 240, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Alprazolam-DDI", "Simulation": "Pourbaix 1985 - alprazolam 0.5 mg TID + cimetidine 200/400 mg QID", "StartTime": 336, "EndTime": 408, "TimeUnit": "h" } } ] }, { "Caption": "Cimetidine + Midazolam (iv)", "Color": "#008000", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1319, "SimulationControl": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam iv control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam iv + 300 mg cimetidine QID", "StartTime": 24, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Cimetidine + Midazolam (po)", "Color": "#008000", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1321, "SimulationControl": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam po control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Greenblatt 1986, Midazolam po + 300 mg cimetidine QID", "StartTime": 24, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1322, "SimulationControl": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Martinez 1999, Midazolam po control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Martinez 1999, Midazolam po + 800 mg cimetidine", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1324, "SimulationControl": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Fee 1987, Midazolam po control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Fee 1987, Midazolam po + 400 mg cimetidine BID", "StartTime": 25, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1326, "SimulationControl": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Salonen 1986, Midazolam po control", "StartTime": 0, "EndTime": 5, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Salonen 1986, Midazolam po + 400 mg cimetidine", "StartTime": 2, "EndTime": 7, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1346, "SimulationControl": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Elliott 1984, Midazolam po control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Midazolam-DDI", "Simulation": "Elliott 1984, Midazolam po + 200/400 mg cimetidine", "StartTime": 26.5, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Cimetidine + Triazolam (po)", "Color": "#FF00FF", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1334, "SimulationControl": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Abernethy 1983/Friedman 1988 - Triazolam control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Abernethy 1983 - Triazolam + cimetidine 300 mg QID", "StartTime": 12, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1336, "SimulationControl": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Abernethy 1983/Friedman 1988 - Triazolam control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Friedman 1988 - Triazolam + cimetidine 300 mg QID", "StartTime": 24, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1342, "SimulationControl": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Pourbaix 1985 - Triazolam control", "StartTime": 144, "EndTime": 168, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Pourbaix 1985 - Triazolam + cimetidine 200/400 mg QID", "StartTime": 327, "EndTime": 351, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1338, "SimulationControl": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Cox 1986 - Triazolam intraduodenal control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Triazolam-DDI", "Simulation": "Cox 1986 - Triazolam intraduodenal + cimetidine 300 mg QID", "StartTime": 13, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Cimetidine + Verapamil (iv)", "Color": "#FF8000", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1328, "SimulationControl": { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 10 mg iv control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 10 mg iv + cimetidine 300 mg qid", "StartTime": 168, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Cimetidine + Verapamil (po)", "Color": "#FF8000", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1330, "SimulationControl": { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 120 mg po control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Verapamil-DDI", "Simulation": "Smith 1984 - Verapamil 120 mg po + 300 mg cimetidine qid", "StartTime": 168, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Clarithromycin + Midazolam (iv)", "Color": "#00C0C0", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 175, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 0.05 mg/kg iv", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 0.05 mg/kg iv, Clari 500 mg BID po, day 7", "StartTime": 146, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2027, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - iv - Quinney 2008", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - iv - Quinney 2008", "StartTime": 146, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Clarithromycin + Midazolam (po)", "Color": "#00C0C0", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 173, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 4 mg po", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Gorski 1998, Midazolam 4 mg po, Clari 500 mg BID po, day 7", "StartTime": 146, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 217, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2006", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - Gurley 2006", "StartTime": 146, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 223, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2008a", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - Gurley 2008a", "StartTime": 146, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 354, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Markert 2013, Midazolam 3 mg po", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Markert 2013, Midazolam 3 mg po, Clari 500 mg BID po day 3", "StartTime": 72.25, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1099, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Prueksaritanont 2017", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - Prueksaritanont 2017", "StartTime": 72, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2030, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - po - Quinney 2008", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Clarithromycin/Midazolam - po - Quinney 2008", "StartTime": 146, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2004, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - van Dyk 2018", "StartTime": 0, "EndTime": 6, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Clarithromycin/Midazolam - van Dyk 2018", "StartTime": 324, "EndTime": 330, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 469, "SimulationControl": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Yeates 1996, Midazolam 15 mg po", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Midazolam-DDI", "Simulation": "Yeates 1996, Midazolam 15 mg po, Clari 250 mg BID po day 5", "StartTime": 97.5, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Clarithromycin + Triazolam (po)", "Color": "#C000C0", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1102, "SimulationControl": { "Project": "Clarithromycin-Triazolam-DDI", "Simulation": "Greenblatt 1998a - Triazolam control - 0.125 mg PO SD", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Clarithromycin-Triazolam-DDI", "Simulation": "Greenblatt 1998a - Clarithromycin 500 mg MD, Triazolam 0.125 mg PO", "StartTime": 25, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Erythromycin + Alfentanil (iv)", "Color": "#C04000", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 779, "SimulationControl": { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Perpetrator_Day1", "StartTime": 1.5, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 780, "SimulationControl": { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Alfentanil-DDI", "Simulation": "Bartkowski1989_Perpetrator_Day7", "StartTime": 145.5, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Erythromycin + Alprazolam (po)", "Color": "#00FF00", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 777, "SimulationControl": { "Project": "Erythromycin-Alprazolam-DDI", "Simulation": "Yasui1996_Control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Alprazolam-DDI", "Simulation": "Yasui1996_Perpetrator", "StartTime": 170, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Erythromycin + Triazolam (po)", "Color": "#808080", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 781, "SimulationControl": { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Greenblatt1998_Control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Greenblatt1998_Perpetrator", "StartTime": 25, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 757, "SimulationControl": { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Phillips1986_Control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Triazolam-DDI", "Simulation": "Phillips1986_Perpetrator", "StartTime": 64, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Erythromycin + Midazolam (iv)", "Color": "#C0C000", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 420, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Swart2002", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Swart2002", "StartTime": 96, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 368, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Olkkola1993_IV", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Olkkola1993_IV", "StartTime": 128, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Erythromycin + Midazolam (po)", "Color": "#C0C000", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 366, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Olkkola1993_Oral", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Olkkola1993_Oral", "StartTime": 128, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 471, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Zimmermann1996", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Zimmermann1996", "StartTime": 97.5, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 362, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Okudaira2007_EM0", "StartTime": 0, "EndTime": 25, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Okudaira2007_EM2", "StartTime": 25, "EndTime": 73, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 363, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Okudaira2007_EM0", "StartTime": 0, "EndTime": 25, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Okudaira2007_EM4", "StartTime": 73, "EndTime": 145, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 364, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Okudaira2007_EM0", "StartTime": 0, "EndTime": 25, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Okudaira2007_EM7", "StartTime": 145, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 828, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Carls2014", "StartTime": 2, "EndTime": 4, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Carls2014_250mg", "StartTime": 3, "EndTime": 5, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 829, "SimulationControl": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Control_Carls2014", "StartTime": 2, "EndTime": 4, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Midazolam-DDI", "Simulation": "Treatment_Carls2014_1000mg", "StartTime": 3, "EndTime": 5, "TimeUnit": "h" } } ] }, { "Caption": "Fluvoxamine + Alprazolam (po)", "Color": "#8080FF", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1104, "SimulationControl": { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Alprazolam", "StartTime": 0, "EndTime": 5, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Fluvoxamine_Alprazolam", "StartTime": 144, "EndTime": 149, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1113, "SimulationControl": { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Alprazolam", "StartTime": 72, "EndTime": 96, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluvoxamine-Alprazolam-DDI", "Simulation": "Fleishaker1994_Fluvoxamine_Alprazolam", "StartTime": 216, "EndTime": 240, "TimeUnit": "h" } } ] }, { "Caption": "Fluvoxamine + Midazolam (iv)", "Color": "#0000C0", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2007, "SimulationControl": { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kashuba 1998", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "DDI Treatment - Fluvoxamine/Midazolam - Kashuba 1998", "StartTime": 517, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Fluvoxamine + Midazolam (po)", "Color": "#0000C0", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1089, "SimulationControl": { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "Lam 2003, 10 mg, SD, midazolam control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluvoxamine-Midazolam-DDI", "Simulation": "Lam 2003, 10 mg SD, midazolam with fluvoxamine", "StartTime": 265, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Itraconazole + Alprazolam (po)", "Color": "#00C000", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1026, "SimulationControl": { "Project": "Itraconazole-Alprazolam-DDI", "Simulation": "Yasui 1998 - Alprazolam 0.8 mg with placebo", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Alprazolam-DDI", "Simulation": "Yasui 1998 - Alprazolam 0.8 mg with itraconazole", "StartTime": 73, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Itraconazole + Midazolam (iv)", "Color": "#C00000", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 378, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1996 (iv, day 4)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "StartTime": 74, "EndTime": 122, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 199, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Yu 2004 (CYP3A5 s3,s3)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "StartTime": 72, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Itraconazole + Midazolam (po)", "Color": "#C00000", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 50, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Ahonen 1995", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Ahonen 1995", "StartTime": 74, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 58, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1998", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "StartTime": 74, "EndTime": 170, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 59, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1998", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Backman 1998", "StartTime": 170, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 370, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1994", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1994", "StartTime": 73, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 377, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "StartTime": 2, "EndTime": 74, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 379, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Olkkola 1996 (po, day 1 and 6)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Olkkola 1996", "StartTime": 122, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1097, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Prueksaritanont 2017", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Prueksaritanont 2017", "StartTime": 72, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 424, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Templeton 2010", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (50 mg)", "StartTime": 4, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 425, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Templeton 2010", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (200 mg)", "StartTime": 4, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 426, "SimulationControl": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Templeton 2010", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Midazolam-DDI", "Simulation": "DDI Treatment - Itraconazole/Midazolam - Templeton 2010 (400 mg)", "StartTime": 4, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Itraconazole + Triazolam (po)", "Color": "#FFFF00", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1078, "SimulationControl": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg simultaneously", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1079, "SimulationControl": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 3 hrs before", "StartTime": 3, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1080, "SimulationControl": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 12 hrs before", "StartTime": 12, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1081, "SimulationControl": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Neuvonen 1996 - Triazolam 0.25 mg + ITZ 200 mg 24 hrs before", "StartTime": 24, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1029, "SimulationControl": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Varhe 1994 - Triazolam 0.25 mg control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Itraconazole-Triazolam-DDI", "Simulation": "Varhe 1994 - Triazolam 0.25 mg + Itraconazole 200 mg PO QD", "StartTime": 73, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Verapamil + Midazolam (iv)", "Color": "#008080", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1111, "SimulationControl": { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Wang 2005", "StartTime": 0, "EndTime": 24, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Treatment - Verapamil/Midazolam - Wang 2005", "StartTime": 168, "EndTime": 192, "TimeUnit": "h" } } ] }, { "Caption": "Verapamil + Midazolam (po)", "Color": "#008080", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1108, "SimulationControl": { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1994", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Treatment - Verapamil/Midazolam - Backman 1994", "StartTime": 25, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1116, "SimulationControl": { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Wang 2005", "StartTime": 24, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Verapamil-Midazolam-DDI", "Simulation": "DDI Treatment - Verapamil/Midazolam - Wang 2005", "StartTime": 192, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Efavirenz + Alfentanil (iv)", "Color": "#800080", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 803, "SimulationControl": { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil IV alone", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD", "StartTime": 360.5, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Efavirenz + Alfentanil (po)", "Color": "#800080", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 801, "SimulationControl": { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil PO alone", "StartTime": 0, "EndTime": 24, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Alfentanil-DDI", "Simulation": "Kharasch 2012, Alfentanil + Efavirenz 600 mg OD", "StartTime": 336.5, "EndTime": 360.5, "TimeUnit": "h" } } ] }, { "Caption": "Efavirenz + Midazolam (iv)", "Color": "#804040", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2045, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 6, "EndTime": 14, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 18, "EndTime": 26, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2048, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 6, "EndTime": 14, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 138, "EndTime": 146, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2050, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 6, "EndTime": 14, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 258, "EndTime": 266, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2052, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 6, "EndTime": 14, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 378, "EndTime": 386, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2054, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 6, "EndTime": 14, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 522, "EndTime": 530, "TimeUnit": "h" } } ] }, { "Caption": "Efavirenz + Midazolam (po)", "Color": "#804040", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2041, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Katzenmaier 2010, Midazolam alone", "StartTime": 0, "EndTime": 10, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Katzenmaier 2010, Midazolam + Efavirenz 400mg MD", "StartTime": 336, "EndTime": 340, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2044, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 0, "EndTime": 6, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 12, "EndTime": 18, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2047, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 0, "EndTime": 6, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 132, "EndTime": 138, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2049, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 0, "EndTime": 6, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 252, "EndTime": 258, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2051, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 0, "EndTime": 6, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 372, "EndTime": 378, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2053, "SimulationControl": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam alone", "StartTime": 0, "EndTime": 6, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Midazolam-DDI", "Simulation": "Mikus 2017, Midazolam + Efavirenz 400mg SD", "StartTime": 516, "EndTime": 522, "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Alfentanil (iv)", "Color": "#80FF80", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 278, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 1997 20 µg/kg IV - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 1997 20 µg/kg IV and Rifampicin", "StartTime": 120.5, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 283, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 15 µg/kg IV - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 15 µg/kg IV and Rifampicin", "StartTime": 105, "EndTime": 129, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 299, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 5 mg Rifampicin", "StartTime": 109, "EndTime": 133, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 300, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 10 mg Rifampicin", "StartTime": 109, "EndTime": 133, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 301, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 25 mg Rifampicin", "StartTime": 109, "EndTime": 133, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 302, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 15 µg/kg IV and 75 mg Rifampicin", "StartTime": 109, "EndTime": 133, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 763, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b IV 1mg - control", "StartTime": 0, "EndTime": 24, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 1 mg IV seq and 600 mg Rifampicin", "StartTime": 108, "EndTime": 132, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 767, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b IV 1mg - control", "StartTime": 24, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 1 mg IV simultaneous and 600 mg Rifampicin", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 391, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Phimmasone 2001 15 µg/kg IV - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Phimmasone 2001 0.015 µg/kg IV and 600 mg Rifampicin", "StartTime": 107, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Alfentanil (po)", "Color": "#80FF80", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 288, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 60 µg/kg PO - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2004 60 µg/kg PO and Rifampicin", "StartTime": 129, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 309, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 5 mg Rifampicin", "StartTime": 133, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 310, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 10 mg Rifampicin", "StartTime": 133, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 311, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 25 mg Rifampicin", "StartTime": 133, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 312, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO - control", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011 75 µg/kg PO and 75 mg Rifampicin", "StartTime": 133, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 771, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b PO 4mg - control", "StartTime": 0, "EndTime": 21, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 4 mg PO seq and 600 mg Rifampicin", "StartTime": 111, "EndTime": 132, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 775, "SimulationControl": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b PO 4mg - control", "StartTime": 21, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alfentanil-DDI", "Simulation": "Kharasch 2011b 4 mg PO simultaneous and 600 mg Rifampicin", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Alprazolam (po)", "Color": "#808000", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2009, "SimulationControl": { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam + Rifampicin", "StartTime": 100, "EndTime": 436, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2010, "SimulationControl": { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Gashaw 2003 - Alprazolam + Rifampicin", "StartTime": 436, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1001, "SimulationControl": { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Schmider 1999 - Alprazolam control", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Alprazolam-DDI", "Simulation": "Schmider 1999 - Alprazolam + Rifampicin", "StartTime": 96, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Midazolam (iv)", "Color": "#FF8080", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 179, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gorski 2003 (iv)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (iv)", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 276, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 1997", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 1997", "StartTime": 120, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 280, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2004 (iv)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "StartTime": 104, "EndTime": 128, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 294, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (iv)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "StartTime": 108, "EndTime": 132, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 295, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (iv)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "StartTime": 108, "EndTime": 132, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 296, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (iv)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "StartTime": 108, "EndTime": 132, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 297, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (iv)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "StartTime": 108, "EndTime": 132, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2036, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kim 2018 (male)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kim 2018 (male)", "StartTime": 216, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 342, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Link 2008 (iv)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Link 2008 (iv)", "StartTime": 144, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 389, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Phimmasone 2001", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Phimmasone 2001", "StartTime": 106, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1092, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Shin 2013", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Shin 2013", "StartTime": 216, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1095, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Shin 2016", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Shin 2016", "StartTime": 216, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 422, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Szalat 2007", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Szalat 2007", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 202, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Yu 2018 (CYP3A5 s3,s3)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Yu 2004 (CYP3A5 s3,s3)", "StartTime": 240, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Midazolam (po)", "Color": "#FF8080", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 54, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1996", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Backman 1996", "StartTime": 113, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 56, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1998", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "StartTime": 113, "EndTime": 185, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 57, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Backman 1998", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Backman 1998", "StartTime": 185, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1355, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Björkhem-Bergman 2013", "StartTime": 0, "EndTime": 10, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 10 mg)", "StartTime": 336, "EndTime": 346, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1356, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Björkhem-Bergman 2013", "StartTime": 0, "EndTime": 10, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 20 mg)", "StartTime": 336, "EndTime": 346, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1357, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Björkhem-Bergman 2013", "StartTime": 0, "EndTime": 10, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Björkhem-Bergman 2013 (RIF @ 100 mg)", "StartTime": 336, "EndTime": 346, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1362, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Chattopadhyay 2018", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Chattopadhyay 2018", "StartTime": 168, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 113, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Chung 2006", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Chung 2006", "StartTime": 166, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 132, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Eap 2004 (7.5 mg)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Eap 2004", "StartTime": 114, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Whole Blood (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 177, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gorski 2003 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gorski 2003 (po)", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 215, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2006", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gurley 2006", "StartTime": 146, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 221, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Gurley 2008", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Gurley 2008", "StartTime": 146, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 286, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2004 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2004", "StartTime": 128, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 304, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 5 mg)", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 305, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 10 mg)", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 306, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 25 mg)", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 307, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Kharasch 2011 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Kharasch 2011 (RIF @ 75 mg)", "StartTime": 132, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 344, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Link 2008 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Link 2008 (po)", "StartTime": 144, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1350, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Lutz 2018 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "StartTime": 228, "EndTime": 660, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1351, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Lutz 2018 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "StartTime": 228, "EndTime": 660, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1352, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Lutz 2018 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 1, 10 and 75 mg RIF)", "StartTime": 660, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1353, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Lutz 2018 (po)", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Lutz 2018 (Cohort 2, 2 and 600 mg RIF)", "StartTime": 660, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1098, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Prueksaritanont 2017", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Prueksaritanont 2017", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 392, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "StartTime": 1320, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "StartTime": 648, "EndTime": 816, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 393, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "StartTime": 1320, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "StartTime": 816, "EndTime": 984, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 394, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "StartTime": 1320, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Reitman 2011", "StartTime": 984, "EndTime": 1320, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2002, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - van Dyk 2018", "StartTime": 0, "EndTime": 6, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - van Dyk 2018", "StartTime": 156, "EndTime": 162, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 204, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Wiesinger 2020", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "StartTime": 180, "EndTime": 444, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 205, "SimulationControl": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Control - Midazolam - Wiesinger 2020", "StartTime": 0, "EndTime": 9999, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Midazolam-DDI", "Simulation": "DDI Treatment - Rifampicin/Midazolam - Wiesinger 2020", "StartTime": 444, "EndTime": 9999, "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Triazolam (po)", "Color": "#ECD33A", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1004, "SimulationControl": { "Project": "Rifampicin-Triazolam-DDI", "Simulation": "Villikka 1997 - Triazolam control - 0.5 mg SD PO", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Triazolam-DDI", "Simulation": "Villikka 1997 - Rifampicin 600 mg over 5 days and Triazolam 0.5 mg SD PO", "StartTime": 113, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Verapamil (iv)", "Color": "#996699", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2056, "SimulationControl": { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Control - Verapamil - Barbarash 1988 (iv)", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (iv)", "StartTime": 300, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Rifampicin + Verapamil (po)", "Color": "#996699", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Verapamil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 2058, "SimulationControl": { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Control - Verapamil - Barbarash 1988 (po)", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Rifampicin-Verapamil-DDI", "Simulation": "DDI Treatment - Rifampicin/Verapamil - Barbarash 1988 (po)", "StartTime": 348, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Fluconazole + Alfentanil (iv)", "Color": "#e9a3c9", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1398, "SimulationControl": { "Project": "Fluconazole-Alfentanil-DDI", "Simulation": "Alfentanil placebo", "StartTime": 1, "EndTime": 11, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Alfentanil-DDI", "Simulation": "Alfentanil -Fluconzole i.v. DDI", "StartTime": 1, "EndTime": 11, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Alfentanil|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1399, "SimulationControl": { "Project": "Fluconazole-Alfentanil-DDI", "Simulation": "Alfentanil placebo", "StartTime": 1, "EndTime": 11, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Alfentanil-DDI", "Simulation": "Alfentanil -Fluconzole oral. DDI", "StartTime": 1, "EndTime": 11, "TimeUnit": "h" } } ] }, { "Caption": "Fluconazole + Midazolam (po)", "Color": "#01665e", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1392, "SimulationControl": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Ahonen_midazolam_po_7.5mg_placebo", "StartTime": 1, "EndTime": 8, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_i.v_DDI", "StartTime": 1, "EndTime": 8, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1393, "SimulationControl": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Ahonen_midazolam_po_7.5mg_placebo", "StartTime": 1, "EndTime": 8, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Ahonen_midazolam_po_7.5mg_fluconazole_400mg_po_DDI", "StartTime": 1, "EndTime": 8, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 380, "SimulationControl": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_placebo_day 1", "StartTime": 0, "EndTime": 7, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_fluconazole_DDI_day 1", "StartTime": 0, "EndTime": 7, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 382, "SimulationControl": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_placebo_day 6", "StartTime": 0, "EndTime": 17, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_fluconazole_DDI_day 6", "StartTime": 122, "EndTime": 139, "TimeUnit": "h" } } ] }, { "Caption": "Fluconazole + Midazolam (iv)", "Color": "#01665e", "Symbol": "Square", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 381, "SimulationControl": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_placebo_day 4", "StartTime": 0, "EndTime": 7, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Midazolam-DDI", "Simulation": "Olkkola_midazolam_fluconazole_DDI_day 4", "StartTime": 74, "EndTime": 91, "TimeUnit": "h" } } ] }, { "Caption": "Fluconazole + Triazolam (po)", "Color": "#dfc27d", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1394, "SimulationControl": { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po placebo", "StartTime": 0, "EndTime": 18, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po fluconazole 50mg", "StartTime": 73, "EndTime": 91, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1395, "SimulationControl": { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po placebo", "StartTime": 0, "EndTime": 18, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po fluconazole 100mg", "StartTime": 73, "EndTime": 91, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1396, "SimulationControl": { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po placebo", "StartTime": 0, "EndTime": 18, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Fluconazole-Triazolam-DDI", "Simulation": "Varhe triazolam 0.25 mg po fluconazole 200mg", "StartTime": 73, "EndTime": 91, "TimeUnit": "h" } } ] }, { "Caption": "Carbamazepine + Alprazolam (po)", "Color": "#FF5050", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Alprazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1457, "SimulationControl": { "Project": "Carbamazepine-Alprazolam-DDI", "Simulation": "Furukori1998_ControlPhase", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Carbamazepine-Alprazolam-DDI", "Simulation": "Furukori1998_TreatmentPhase", "StartTime": 170, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Carbamazepine + Midazolam (po)", "Color": "#5C0000", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 943, "SimulationControl": { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study1_ControlPhase", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study1_TreatmentPhase", "StartTime": 334, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1133, "SimulationControl": { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study2_ControlPhase", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Kanefendt2023_Study2_TreatmentPhase", "StartTime": 336, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Midazolam|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1460, "SimulationControl": { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Lutz2018_ControlPhase", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Carbamazepine-Midazolam-DDI", "Simulation": "Lutz2018_TreatmentPhase", "StartTime": 404, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Carbamazepine + Efavirenz (po)", "Color": "#B06900", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Efavirenz|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 959, "SimulationControl": { "Project": "Carbamazepine-Efavirenz-DDI", "Simulation": "Ji2008_Arm1_ControlPhase", "StartTime": 312, "EndTime": 336, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Carbamazepine-Efavirenz-DDI", "Simulation": "Ji2008_Arm1_TreatmentPhase", "StartTime": 816, "EndTime": 840, "TimeUnit": "h" } } ] }, { "Caption": "Erythromycin + Carbamazepine (po)", "Color": "#7030A0", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 465, "SimulationControl": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Barzaghi1987_ControlPhase", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Barzaghi1987_TreatmentPhase", "StartTime": 144, "EndTime": "Inf", "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1157, "SimulationControl": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_ControlPhase_300mg", "StartTime": 312, "EndTime": 336, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_TreatmentPhase_300mg", "StartTime": 384, "EndTime": 408, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1158, "SimulationControl": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_ControlPhase_400mg", "StartTime": 312, "EndTime": 336, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Miles1989_TreatmentPhase_400mg", "StartTime": 384, "EndTime": 408, "TimeUnit": "h" } }, { "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 1154, "SimulationControl": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Wong1983_ControlPhase", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Erythromycin-Carbamazepine-DDI", "Simulation": "Wong1983_TreatmentPhase", "StartTime": 120, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Cimetidine + Carbamazepine (po)", "Color": "#9BC2E6", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 900, "SimulationControl": { "Project": "Cimetidine-Carbamazepine-DDI", "Simulation": "Dalton1985a_ControlPhase", "StartTime": 0, "EndTime": "Inf", "TimeUnit": "h" }, "SimulationDDI": { "Project": "Cimetidine-Carbamazepine-DDI", "Simulation": "Dalton1985a_TreatmentPhase", "StartTime": 48, "EndTime": "Inf", "TimeUnit": "h" } } ] }, { "Caption": "Efavirenz + Carbamazepine (po)", "Color": "#B4B4B4", "Symbol": "Circle", "DDIRatios": [ { "Output": "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)", "ObservedData": "DDI Ratios", "ObservedDataRecordId": 961, "SimulationControl": { "Project": "Efavirenz-Carbamazepine-DDI", "Simulation": "Ji2008_Arm2_ControlPhase", "StartTime": 480, "EndTime": 504, "TimeUnit": "h" }, "SimulationDDI": { "Project": "Efavirenz-Carbamazepine-DDI", "Simulation": "Ji2008_Arm2_TreatmentPhase", "StartTime": 816, "EndTime": 840, "TimeUnit": "h" } } ] } ] } ] }, "Inputs": [], "Sections": [ { "Id": 1, "Title": "1 Introduction", "Content": "Content/Empty.md", "Sections": [ { "Id": 11, "Title": "1.1 Objective", "Content": "Content/Qualification_DDI_CYP3A4_objective.md" }, { "Id": 12, "Title": "1.2 CYP3A4 DDI Network", "Content": "Content/Qualification_DDI_CYP3A4_network_description.md", "Sections": [ { "Id": 1201, "Title": "Carbamazepine - Alprazolam DDI", "Content": "Content/Carbamazepine-Alprazolam-DDI.md" }, { "Id": 1202, "Title": "Carbamazepine - Efavirenz DDI", "Content": "Content/Carbamazepine-Efavirenz-DDI.md" }, { "Id": 1203, "Title": "Carbamazepine - Midazolam DDI", "Content": "Content/Carbamazepine-Midazolam-DDI.md" }, { "Id": 1204, "Title": "Cimetidine - Alfentanil DDI", "Content": "Content/Cimetidine-Alfentanil-DDI.md" }, { "Id": 1205, "Title": "Cimetidine - Alprazolam DDI", "Content": "Content/Cimetidine-Alprazolam-DDI.md" }, { "Id": 1206, "Title": "Cimetidine - Carbamazepine DDI", "Content": "Content/Cimetidine-Carbamazepine-DDI.md" }, { "Id": 1207, "Title": "Cimetidine - Midazolam DDI", "Content": "Content/Cimetidine-Midazolam-DDI.md" }, { "Id": 1208, "Title": "Cimetidine - Triazolam DDI", "Content": "Content/Cimetidine-Triazolam-DDI.md" }, { "Id": 1209, "Title": "Cimetidine - Verapamil DDI", "Content": "Content/Cimetidine-Verapamil-DDI.md" }, { "Id": 1210, "Title": "Clarithromycin - Midazolam DDI", "Content": "Content/Clarithromycin-Midazolam-DDI.md" }, { "Id": 1211, "Title": "Clarithromycin - Triazolam DDI", "Content": "Content/Clarithromycin-Triazolam-DDI.md" }, { "Id": 1212, "Title": "Efavirenz - Alfentanil-DDI", "Content": "Content/Efavirenz-Alfentanil-DDI.md" }, { "Id": 1213, "Title": "Efavirenz - Carbamazepine DDI", "Content": "Content/Efavirenz-Carbamazepine-DDI.md" }, { "Id": 1214, "Title": "Efavirenz - Midazolam DDI", "Content": "Content/Efavirenz-Midazolam-DDI.md" }, { "Id": 1215, "Title": "Erythromycin - Alfentanil DDI", "Content": "Content/Erythromycin-Alfentanil-DDI.md" }, { "Id": 1216, "Title": "Erythromycin - Alprazolam DDI", "Content": "Content/Erythromycin-Alprazolam-DDI.md" }, { "Id": 1217, "Title": "Erythromycin - Carbamazepine DDI", "Content": "Content/Erythromycin-Carbamazepine-DDI.md" }, { "Id": 1218, "Title": "Erythromycin - Midazolam DDI", "Content": "Content/Erythromycin-Midazolam-DDI.md" }, { "Id": 1219, "Title": "Erythromycin - Triazolam DDI", "Content": "Content/Erythromycin-Triazolam-DDI.md" }, { "Id": 1220, "Title": "Fluconazole - Alfentanil DDI", "Content": "Content/Fluconazole-Alfentanil-DDI.md" }, { "Id": 1221, "Title": "Fluconazole - Midazolam DDI", "Content": "Content/Fluconazole-Midazolam-DDI.md" }, { "Id": 1222, "Title": "Fluconazole - Triazolam DDI", "Content": "Content/Fluconazole-Triazolam-DDI.md" }, { "Id": 1223, "Title": "Fluvoxamine - Alprazolam DDI", "Content": "Content/Fluvoxamine-Alprazolam-DDI.md" }, { "Id": 1224, "Title": "Fluvoxamine - Midazolam DDI", "Content": "Content/Fluvoxamine-Midazolam-DDI.md" }, { "Id": 1225, "Title": "Itraconazole - Alprazolam DDI", "Content": "Content/Itraconazole-Alprazolam-DDI.md" }, { "Id": 1226, "Title": "Itraconazole - Midazolam DDI", "Content": "Content/Itraconazole-Midazolam-DDI.md" }, { "Id": 1227, "Title": "Itraconazole - Triazolam DDI", "Content": "Content/Itraconazole-Triazolam-DDI.md" }, { "Id": 1228, "Title": "Rifampicin - Alfentanil DDI", "Content": "Content/Rifampicin-Alfentanil-DDI.md" }, { "Id": 1229, "Title": "Rifampicin - Alprazolam DDI", "Content": "Content/Rifampicin-Alprazolam-DDI.md" }, { "Id": 1230, "Title": "Rifampicin - Midazolam DDI", "Content": "Content/Rifampicin-Midazolam-DDI.md" }, { "Id": 1231, "Title": "Rifampicin - Triazolam DDI", "Content": "Content/Rifampicin-Triazolam-DDI.md" }, { "Id": 1232, "Title": "Rifampicin - Verapamil DDI", "Content": "Content/Rifampicin-Verapamil-DDI.md" }, { "Id": 1233, "Title": "Verapamil - Midazolam DDI", "Content": "Content/Verapamil-Midazolam-DDI.md" } ] } ] }, { "Id": 2, "Title": "2 Qualification of Use Case CYP3A4-mediated DDI", "Content": "Content/Intro_evaluation_DDI_network.md" }, { "Id": 3, "Title": "3 Concentration-Time Profiles", "Content": "Content/Intro_evaluation_CTprofiles.md", "Sections": [ { "Id": 301, "Title": "3.1 Carbamazepine - Alprazolam DDI", "Content": "Content/Empty.md" }, { "Id": 302, "Title": "3.2 Carbamazepine - Efavirenz DDI", "Content": "Content/Empty.md" }, { "Id": 303, "Title": "3.3 Carbamazepine - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 304, "Title": "3.4 Cimetidine - Alfentanil DDI", "Content": "Content/Empty.md" }, { "Id": 305, "Title": "3.5 Cimetidine - Alprazolam DDI", "Content": "Content/Empty.md" }, { "Id": 306, "Title": "3.6 Cimetidine - Carbamazepine DDI", "Content": "Content/Empty.md" }, { "Id": 307, "Title": "3.7 Cimetidine - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 308, "Title": "3.8 Cimetidine - Triazolam DDI", "Content": "Content/Empty.md" }, { "Id": 309, "Title": "3.9 Cimetidine - Verapamil DDI", "Content": "Content/Empty.md" }, { "Id": 310, "Title": "3.10 Clarithromycin - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 311, "Title": "3.11 Clarithromycin - Triazolam DDI", "Content": "Content/Empty.md" }, { "Id": 312, "Title": "3.12 Efavirenz - Alfentanil DDI", "Content": "Content/Empty.md" }, { "Id": 313, "Title": "3.13 Efavirenz - Carbamazepine DDI", "Content": "Content/Empty.md" }, { "Id": 314, "Title": "3.14 Efavirenz - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 315, "Title": "3.15 Erythromycin - Alfentanil DDI", "Content": "Content/Empty.md" }, { "Id": 316, "Title": "3.16 Erythromycin - Alprazolam DDI", "Content": "Content/Empty.md" }, { "Id": 317, "Title": "3.17 Erythromycin - Carbamazepine DDI", "Content": "Content/Empty.md" }, { "Id": 318, "Title": "3.18 Erythromycin - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 319, "Title": "3.19 Erythromycin - Triazolam DDI", "Content": "Content/Empty.md" }, { "Id": 320, "Title": "3.20 Fluconazole - Alfentanil DDI", "Content": "Content/Empty.md" }, { "Id": 321, "Title": "3.21 Fluconazole - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 322, "Title": "3.22 Fluconazole - Triazolam DDI", "Content": "Content/Empty.md" }, { "Id": 323, "Title": "3.23 Fluvoxamine - Alprazolam DDI", "Content": "Content/Empty.md" }, { "Id": 324, "Title": "3.24 Fluvoxamine - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 325, "Title": "3.25 Itraconazole - Alprazolam DDI", "Content": "Content/Empty.md" }, { "Id": 326, "Title": "3.26 Itraconazole - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 327, "Title": "3.27 Itraconazole - Triazolam DDI", "Content": "Content/Empty.md" }, { "Id": 328, "Title": "3.28 Rifampicin - Alfentanil DDI", "Content": "Content/Empty.md" }, { "Id": 329, "Title": "3.29 Rifampicin - Alprazolam DDI", "Content": "Content/Empty.md" }, { "Id": 330, "Title": "3.30 Rifampicin - Midazolam DDI", "Content": "Content/Empty.md" }, { "Id": 331, "Title": "3.31 Rifampicin - Triazolam DDI", "Content": "Content/Empty.md" }, { "Id": 332, "Title": "3.32 Rifampicin - Verapamil DDI", "Content": "Content/Empty.md" }, { "Id": 333, "Title": "3.33 Verapamil - Midazolam DDI", "Content": "Content/Empty.md" } ] }, { "Id": 4, "Title": "4 References", "Content": "Content/References.md", "Sections": [] }, { "Id": 5, "Title": "5 Appendix", "Content": "Content/Empty.md", "Sections": [ { "Id": 51, "Title": "5.1 Open Systems Pharmacology Suite (OSPS) Introduction", "Content": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Qualification-text-modules/v1.3/OSPS_Introduction.md" }, { "Id": 52, "Title": "5.2 Mathematical Implementation of Drug-Drug Interactions", "Content": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Qualification-text-modules/v1.3/Mathematical_Implementation_of_DDI.md" }, { "Id": 53, "Title": "5.3 Automatic (re)-qualification workflow", "Content": "https://raw.githubusercontent.com/Open-Systems-Pharmacology/Qualification-text-modules/v1.3/Qualification_Workflow.md" } ] } ], "Intro": [ { "Path": "Content/titlepage.md" } ] }