{
  "Version": 80,
  "ExpressionProfiles": [
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT1A1",
      "Category": "Standard European Male for PEQ",
      "Parameters": [
        {
          "Path": "Organism|Gonads|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0013585313175
        },
        {
          "Path": "Organism|Kidney|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0788336933
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|Caecum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.0349892009
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|UGT1A1|Relative expression",
          "Value": 0.00027429805616
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UGT1A1|Relative expression",
          "Value": 0.3239740821
        },
        {
          "Path": "Organism|Stomach|Intracellular|UGT1A1|Relative expression",
          "Value": 0.016349892
        },
        {
          "Path": "UGT1A1|Reference concentration",
          "Value": 1.328,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Publication",
            "Method": "InVitro",
            "Description": "Calculated from Ohtsuki 2012 (PMID 21994437)"
          }
        },
        {
          "Path": "UGT1A1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "UGT1A1"
      }
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT1A9",
      "Category": "Standard European Male for PEQ",
      "Parameters": [
        {
          "Path": "Organism|Gonads|Intracellular|UGT1A9|Relative expression",
          "Value": 0.00016153846154
        },
        {
          "Path": "Organism|Kidney|Intracellular|UGT1A9|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|Caecum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0079487179487
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0982905983
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0982905983
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0041282051282
        },
        {
          "Path": "Organism|Stomach|Intracellular|UGT1A9|Relative expression",
          "Value": 0.0017264957265
        },
        {
          "Path": "UGT1A9|Reference concentration",
          "Value": 10.36,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Publication",
            "Method": "InVitro",
            "Description": "Calculated from Ohtsuki 2012 (PMID 21994437)"
          }
        },
        {
          "Path": "UGT1A9|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A9|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "UGT1A9"
      }
    }
  ],
  "Individuals": [
    {
      "Name": "Standard European Male for PEQ",
      "Seed": 2515843,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "ExpressionProfiles": [
        "UGT1A1|Human|Standard European Male for PEQ",
        "UGT1A9|Human|Standard European Male for PEQ"
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Raltegravir",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Moss 2012",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 0.58,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Moss 2012"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.17,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Laufer 2009"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Moss 2013",
          "Parameters": [
            {
              "Name": "Solubility table",
              "Value": 40.0,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Moss 2013 Table 2"
              },
              "TableFormula": {
                "Name": "Solubility",
                "XName": "pH",
                "XDimension": "Dimensionless",
                "YName": "Solubility",
                "YDimension": "Concentration (mass)",
                "YUnit": "mg/l",
                "UseDerivedValues": false,
                "Points": [
                  {
                    "X": 1.0,
                    "Y": 40.000000000000007,
                    "RestartSolver": false
                  },
                  {
                    "X": 2.5,
                    "Y": 40.000000000000007,
                    "RestartSolver": false
                  },
                  {
                    "X": 3.0,
                    "Y": 40.000000000000007,
                    "RestartSolver": false
                  },
                  {
                    "X": 4.0,
                    "Y": 40.000000000000007,
                    "RestartSolver": false
                  },
                  {
                    "X": 4.4,
                    "Y": 70.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 4.5,
                    "Y": 80.000000000000014,
                    "RestartSolver": false
                  },
                  {
                    "X": 5.0,
                    "Y": 120.00000000000001,
                    "RestartSolver": false
                  },
                  {
                    "X": 5.5,
                    "Y": 330.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 6.0,
                    "Y": 980.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 6.2,
                    "Y": 1600.0000000000002,
                    "RestartSolver": false
                  },
                  {
                    "X": 6.4,
                    "Y": 2400.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 6.5,
                    "Y": 2900.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 6.8,
                    "Y": 5800.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 7.0,
                    "Y": 8900.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 7.4,
                    "Y": 20300.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 7.6,
                    "Y": 30000.0,
                    "RestartSolver": false
                  },
                  {
                    "X": 8.0,
                    "Y": 37300.0,
                    "RestartSolver": false
                  }
                ]
              }
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fit",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 2.8481843854E-07,
              "Unit": "cm/s",
              "ValueOrigin": {
                "Source": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Acid",
          "Pka": 6.67,
          "ValueOrigin": {
            "Source": "Publication",
            "Method": "InVitro",
            "Description": "Moss 2012"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "Kassahun 2007",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Kassahun 2007"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Kassahun 2007",
          "Molecule": "UGT1A1",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 2.7351231632,
              "Unit": "nmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "ParameterIdentification"
              }
            },
            {
              "Name": "Km",
              "Value": 99.0,
              "Unit": "µM",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Kassahun 2007"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Kassahun 2007",
          "Molecule": "UGT1A9",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 1.6287812095,
              "Unit": "nmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "ParameterIdentification"
              }
            },
            {
              "Name": "Km",
              "Value": 296.0,
              "Unit": "µM",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Kassahun 2007"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "F",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Publication",
            "Method": "Other",
            "Description": "Drugbank.ca"
          }
        },
        {
          "Name": "Molecular weight",
          "Value": 444.4163,
          "Unit": "g/mol",
          "ValueOrigin": {
            "Source": "Publication",
            "Method": "Other",
            "Description": "Drugbank.ca"
          }
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "Weibull (lactose formulation)",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 2.30152527E-10,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.0389537131,
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "chewable tablet",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 1.0000049774E-05,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.050078869,
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "filmcoated tablet (original Merck formulation)",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 500.0,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.03536656,
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "Weibull (granules)",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 0.00010000047426,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.0654456264,
          "ValueOrigin": {
            "Source": "ParameterIdentification"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    }
  ],
  "Protocols": [
    {
      "Name": "Iwamoto 2008 400mg PO (Figure 1) omeprazole study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 400.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 10mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 10.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 25mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 25.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 50mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 50.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 100mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 100.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 200mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 200.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 800mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 800.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 1200mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1200.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Iwamoto 2008 1600mg PO (Figure 2) Safety-Tolerability-PK study",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1600.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Markowitz 2006 100mg bid 10d",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_12_12",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 100.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 10.0,
          "Unit": "day(s)",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "Markowitz 2006 200mg bid 10d",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_12_12",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 200.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 10.0,
          "Unit": "day(s)",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "Markowitz 2006 400mg bid 10d",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_12_12",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
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          "ObservedData": "Rhee 2014 - granules suspension - Raltegravir - po - 400 mg - Plasma - agg. (n=12)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 100 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Markowitz 2006 - 100mg FCT MD - Raltegravir - PO - 100 mg - Plasma - agg. (n=7)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 200 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Markowitz 2006 - 200mg FCT MD - Raltegravir - PO - 200 mg - Plasma - agg. (n=7)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 400 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Markowitz 2006 - 400mg FCT MD - Raltegravir - PO - 400 mg - Plasma - agg. (n=6)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 400mg (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 10 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 10mg - Raltegravir - PO - 10 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 25 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 25mg - Raltegravir - PO - 25 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 50 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 50mg - Raltegravir - PO - 50 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 100 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 100mg - Raltegravir - PO - 100 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 200 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 200mg - Raltegravir - PO - 200 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 1600 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 1600mg - Raltegravir - PO - 1600 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 1200 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 1200mg - Raltegravir - PO - 1200 mg - Plasma - agg. (n=24)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 400mg chewable fed|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Rhee 2014 - Chewable tablet fed - Raltegravir - po - 400 mg - Plasma - agg. (n=12)"
        },
        {
          "Scaling": "Log",
          "Path": "Raltegravir 400mg filmcoated tablet|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
          "ObservedData": "Iwamoto 2008 - 400mg FCT - Raltegravir - PO - 400 mg - Plasma - agg. (n=14)"
        }
      ],
      "IdentificationParameters": [
        {
          "Name": "Dis shape filmcoated tablet",
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          "LinkedParameters": [
            "Raltegravir 400mg filmcoated tablet|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|filmcoated tablet (original Merck formulation)|Dissolution shape",
            "Raltegravir 400 mg filmcoated tablet md|Events|Markowitz 2006 400mg bid 10d|filmcoated tablet (original Merck formulation)|Dissolution shape",
            "Raltegravir 200 mg filmcoated tablet md|Events|Markowitz 2006 200mg bid 10d|filmcoated tablet (original Merck formulation)|Dissolution shape",
            "Raltegravir 100 mg filmcoated tablet md|Events|Markowitz 2006 100mg bid 10d|filmcoated tablet (original Merck formulation)|Dissolution shape"
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          "Parameters": [
            {
              "Name": "Start value",
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            {
              "Name": "MinValue",
              "Value": 0.0001
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            {
              "Name": "MaxValue",
              "Value": 5.0
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          ]
        },
        {
          "Name": "Dis time filmcoated tablet",
          "Scaling": "Log",
          "IsFixed": true,
          "LinkedParameters": [
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            "Raltegravir 400 mg filmcoated tablet md|Events|Markowitz 2006 400mg bid 10d|filmcoated tablet (original Merck formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 200 mg filmcoated tablet md|Events|Markowitz 2006 200mg bid 10d|filmcoated tablet (original Merck formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 100 mg filmcoated tablet md|Events|Markowitz 2006 100mg bid 10d|filmcoated tablet (original Merck formulation)|Dissolution time (50% dissolved)"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 500.0,
              "Unit": "min"
            },
            {
              "Name": "MinValue",
              "Value": 0.0001,
              "Unit": "min"
            },
            {
              "Name": "MaxValue",
              "Value": 600.0,
              "Unit": "min"
            }
          ]
        },
        {
          "Name": "dis shape lactose form",
          "Scaling": "Log",
          "IsFixed": true,
          "LinkedParameters": [
            "Raltegravir 50 mg  (lactose formulation)|Events|Iwamoto 2008 50mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 25 mg  (lactose formulation)|Events|Iwamoto 2008 25mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 200 mg   (lactose formulation)|Events|Iwamoto 2008 200mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 1600 mg  (lactose formulation)|Events|Iwamoto 2008 1600mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 10 mg   (lactose formulation)|Events|Iwamoto 2008 10mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 100 mg  (lactose formulation)|Events|Iwamoto 2008 100mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 400mg (lactose formulation)|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 800 mg  (lactose formulation)|Events|Iwamoto 2008 800mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape",
            "Raltegravir 1200 mg   (lactose formulation)|Events|Iwamoto 2008 1200mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution shape"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.0389537131
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            {
              "Name": "MinValue",
              "Value": 0.0001
            },
            {
              "Name": "MaxValue",
              "Value": 5.0
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          ]
        },
        {
          "Name": "dis time lactose form",
          "Scaling": "Log",
          "IsFixed": true,
          "LinkedParameters": [
            "Raltegravir 50 mg  (lactose formulation)|Events|Iwamoto 2008 50mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 25 mg  (lactose formulation)|Events|Iwamoto 2008 25mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 200 mg   (lactose formulation)|Events|Iwamoto 2008 200mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 1600 mg  (lactose formulation)|Events|Iwamoto 2008 1600mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 10 mg   (lactose formulation)|Events|Iwamoto 2008 10mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 100 mg  (lactose formulation)|Events|Iwamoto 2008 100mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 400mg (lactose formulation)|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 800 mg  (lactose formulation)|Events|Iwamoto 2008 800mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)",
            "Raltegravir 1200 mg   (lactose formulation)|Events|Iwamoto 2008 1200mg PO (Figure 2) Safety-Tolerability-PK study|Weibull (lactose formulation)|Dissolution time (50% dissolved)"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 2.30152527E-10,
              "Unit": "min"
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            {
              "Name": "MinValue",
              "Value": 2E-10,
              "Unit": "min"
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            {
              "Name": "MaxValue",
              "Value": 180.0,
              "Unit": "min"
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          ]
        },
        {
          "Name": "Dis time chewable tablet",
          "Scaling": "Log",
          "IsFixed": true,
          "LinkedParameters": [
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            "Raltegravir 400mg chewable fed|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|chewable tablet|Dissolution time (50% dissolved)"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 1.0000049774E-05,
              "Unit": "min"
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            {
              "Name": "MinValue",
              "Value": 1E-05,
              "Unit": "min"
            },
            {
              "Name": "MaxValue",
              "Value": 180.0,
              "Unit": "min"
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          ]
        },
        {
          "Name": "Dis shape chewable tablet",
          "Scaling": "Log",
          "LinkedParameters": [
            "Raltegravir 400mg chewable fasted|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|chewable tablet|Dissolution shape",
            "Raltegravir 400mg chewable fed|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|chewable tablet|Dissolution shape"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.0511891075
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            {
              "Name": "MinValue",
              "Value": 0.0001
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            {
              "Name": "MaxValue",
              "Value": 5.0
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          ]
        },
        {
          "Name": "Lipophilicity",
          "Scaling": "Linear",
          "IsFixed": true,
          "LinkedParameters": [
            "Raltegravir 400mg filmcoated tablet|Raltegravir|Lipophilicity",
            "Raltegravir 10 mg   (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 100 mg  (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 1600 mg  (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 200 mg   (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 25 mg  (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 400mg (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 50 mg  (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 800 mg  (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 400mg chewable fasted|Raltegravir|Lipophilicity",
            "Raltegravir 400mg (granules in suspension)|Raltegravir|Lipophilicity",
            "Raltegravir 100 mg filmcoated tablet md|Raltegravir|Lipophilicity",
            "Raltegravir 200 mg filmcoated tablet md|Raltegravir|Lipophilicity",
            "Raltegravir 400 mg filmcoated tablet md|Raltegravir|Lipophilicity",
            "Raltegravir 1200 mg   (lactose formulation)|Raltegravir|Lipophilicity",
            "Raltegravir 400mg chewable fed|Raltegravir|Lipophilicity"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.58,
              "Unit": "Log Units"
            },
            {
              "Name": "MinValue",
              "Value": -1.6,
              "Unit": "Log Units"
            },
            {
              "Name": "MaxValue",
              "Value": 1.5,
              "Unit": "Log Units"
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          ]
        },
        {
          "Name": "Dissolution shape",
          "Scaling": "Linear",
          "LinkedParameters": [
            "Raltegravir 400mg (granules in suspension)|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|Weibull (granules)|Dissolution shape"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.1010842985
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            {
              "Name": "MinValue",
              "Value": 0.001
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            {
              "Name": "MaxValue",
              "Value": 1.010842985
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          ]
        },
        {
          "Name": "Dissolution time (50% dissolved)",
          "Scaling": "Linear",
          "IsFixed": true,
          "LinkedParameters": [
            "Raltegravir 400mg (granules in suspension)|Events|Iwamoto 2008 400mg PO (Figure 1) omeprazole study|Weibull (granules)|Dissolution time (50% dissolved)"
          ],
          "Parameters": [
            {
              "Name": "Start value",
              "Value": 0.00010000047426,
              "Unit": "min"
            },
            {
              "Name": "MinValue",
              "Value": 1E-05,
              "Unit": "min"
            },
            {
              "Name": "MaxValue",
              "Value": 0.0010000047426,
              "Unit": "min"
            }
          ]
        },
        {
          "Name": "In vitro Vmax for liver microsomes",
          "Scaling": "Linear",
          "UseAsFactor": true,
          "IsFixed": true,
          "LinkedParameters": [
            "Raltegravir 400mg chewable fasted|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg chewable fasted|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg chewable fed|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg chewable fed|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 100 mg filmcoated tablet md|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 100 mg filmcoated tablet md|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 200 mg filmcoated tablet md|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 200 mg filmcoated tablet md|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400 mg filmcoated tablet md|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400 mg filmcoated tablet md|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg filmcoated tablet|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg filmcoated tablet|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg (granules in suspension)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg (granules in suspension)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 10 mg   (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 10 mg   (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 100 mg  (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 100 mg  (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 1200 mg   (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 1200 mg   (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 1600 mg  (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 1600 mg  (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 200 mg   (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 200 mg   (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 25 mg  (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 25 mg  (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 400mg (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 50 mg  (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 50 mg  (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 800 mg  (lactose formulation)|Raltegravir-UGT1A1-Kassahun 2007|In vitro Vmax for liver microsomes",
            "Raltegravir 800 mg  (lactose formulation)|Raltegravir-UGT1A9-Kassahun 2007|In vitro Vmax for liver microsomes"
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          "Parameters": [
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              "Value": 1.0
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            {
              "Name": "MinValue",
              "Value": 0.1
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            {
              "Name": "MaxValue",
              "Value": 10.0
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          ]
        },
        {
          "Name": "Specific intestinal permeability (transcellular)",
          "Scaling": "Log",
          "IsFixed": true,
          "LinkedParameters": [
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            "Raltegravir 400mg chewable fed|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 100 mg filmcoated tablet md|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 200 mg filmcoated tablet md|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 400 mg filmcoated tablet md|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 400mg filmcoated tablet|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 400mg (granules in suspension)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 10 mg   (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 100 mg  (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 1200 mg   (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 1600 mg  (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 200 mg   (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 25 mg  (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 400mg (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 50 mg  (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)",
            "Raltegravir 800 mg  (lactose formulation)|Raltegravir|Specific intestinal permeability (transcellular)"
          ],
          "Parameters": [
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              "Name": "Start value",
              "Value": 2.8481843854E-07,
              "Unit": "cm/s"
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            {
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              "Unit": "cm/s"
            },
            {
              "Name": "MaxValue",
              "Value": 0.0001642,
              "Unit": "cm/s"
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          ]
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      "Analyses": [
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          "Name": "Time Profile",
          "Type": "ParameterIdentificationTimeProfileChart",
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                "Dimension": "Time",
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                "Name": "Wenning 2009 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=10)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Wenning 2009 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=10)|Time",
                "Y": "Wenning 2009 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#0000FF",
                  "LegendIndex": 4,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 400mg FCT - Raltegravir - PO - 400 mg - Plasma - agg. (n=14)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 400mg FCT - Raltegravir - PO - 400 mg - Plasma - agg. (n=14)|Time",
                "Y": "Iwamoto 2008 - 400mg FCT - Raltegravir - PO - 400 mg - Plasma - agg. (n=14)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#0000FF",
                  "LegendIndex": 5,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Rhee 2014 - Chewable tablet fasted - Raltegravir - po - 400 mg - Plasma - agg. (n=12)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Rhee 2014 - Chewable tablet fasted - Raltegravir - po - 400 mg - Plasma - agg. (n=12)|Time",
                "Y": "Rhee 2014 - Chewable tablet fasted - Raltegravir - po - 400 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#008000",
                  "LegendIndex": 6,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Rhee 2014 - granules suspension - Raltegravir - po - 400 mg - Plasma - agg. (n=12)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Rhee 2014 - granules suspension - Raltegravir - po - 400 mg - Plasma - agg. (n=12)|Time",
                "Y": "Rhee 2014 - granules suspension - Raltegravir - po - 400 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#FF00FF",
                  "LegendIndex": 7,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Markowitz 2006 - 100mg FCT MD - Raltegravir - PO - 100 mg - Plasma - agg. (n=7)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Markowitz 2006 - 100mg FCT MD - Raltegravir - PO - 100 mg - Plasma - agg. (n=7)|Time",
                "Y": "Markowitz 2006 - 100mg FCT MD - Raltegravir - PO - 100 mg - Plasma - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#FF8000",
                  "LegendIndex": 8,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Markowitz 2006 - 400mg FCT MD - Raltegravir - PO - 400 mg - Plasma - agg. (n=6)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Markowitz 2006 - 400mg FCT MD - Raltegravir - PO - 400 mg - Plasma - agg. (n=6)|Time",
                "Y": "Markowitz 2006 - 400mg FCT MD - Raltegravir - PO - 400 mg - Plasma - agg. (n=6)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#00C0C0",
                  "LegendIndex": 9,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#C000C0",
                  "LegendIndex": 10,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 10mg - Raltegravir - PO - 10 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 10mg - Raltegravir - PO - 10 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 10mg - Raltegravir - PO - 10 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#C04000",
                  "LegendIndex": 11,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 25mg - Raltegravir - PO - 25 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 25mg - Raltegravir - PO - 25 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 25mg - Raltegravir - PO - 25 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#00FF00",
                  "LegendIndex": 12,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 50mg - Raltegravir - PO - 50 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 50mg - Raltegravir - PO - 50 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 50mg - Raltegravir - PO - 50 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#808080",
                  "LegendIndex": 13,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 100mg - Raltegravir - PO - 100 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 100mg - Raltegravir - PO - 100 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 100mg - Raltegravir - PO - 100 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#C0C000",
                  "LegendIndex": 14,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 200mg - Raltegravir - PO - 200 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 200mg - Raltegravir - PO - 200 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 200mg - Raltegravir - PO - 200 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#8080FF",
                  "LegendIndex": 15,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 1600mg - Raltegravir - PO - 1600 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 1600mg - Raltegravir - PO - 1600 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 1600mg - Raltegravir - PO - 1600 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#0000C0",
                  "LegendIndex": 16,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "Iwamoto 2008 - 1200mg - Raltegravir - PO - 1200 mg - Plasma - agg. (n=24)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Iwamoto 2008 - 1200mg - Raltegravir - PO - 1200 mg - Plasma - agg. (n=24)|Time",
                "Y": "Iwamoto 2008 - 1200mg - Raltegravir - PO - 1200 mg - Plasma - agg. (n=24)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#00C000",
                  "LegendIndex": 17,
                  "LineStyle": "None",
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                }
              },
              {
                "Name": "Rhee 2014 - Chewable tablet fed - Raltegravir - po - 400 mg - Plasma - agg. (n=12)-Raltegravir-Peripheral Venous Blood-Plasma-ArithmeticMean",
                "X": "Rhee 2014 - Chewable tablet fed - Raltegravir - po - 400 mg - Plasma - agg. (n=12)|Time",
                "Y": "Rhee 2014 - Chewable tablet fed - Raltegravir - po - 400 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Raltegravir|ArithmeticMean",
                "CurveOptions": {
                  "VisibleInLegend": false,
                  "Color": "#C00000",
                  "LegendIndex": 18,
                  "LineStyle": "None",
                  "Symbol": "Circle"
                }
              },
              {
                "Name": "1-Raltegravir 50 mg  (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 50 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#808080",
                  "LegendIndex": 19
                }
              },
              {
                "Name": "1-Raltegravir 400mg (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#C000C0",
                  "LegendIndex": 20
                }
              },
              {
                "Name": "1-Raltegravir 25 mg  (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 25 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#00FF00",
                  "LegendIndex": 21
                }
              },
              {
                "Name": "1-Raltegravir 200 mg   (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 200 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#8080FF",
                  "LegendIndex": 22
                }
              },
              {
                "Name": "1-Raltegravir 1600 mg  (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 1600 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#0000C0",
                  "LegendIndex": 23
                }
              },
              {
                "Name": "1-Raltegravir 1200 mg   (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 1200 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#00C000",
                  "LegendIndex": 24
                }
              },
              {
                "Name": "1-Raltegravir 100 mg  (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 100 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#C0C000",
                  "LegendIndex": 25
                }
              },
              {
                "Name": "1-Raltegravir 10 mg   (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 10 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#C04000",
                  "LegendIndex": 26
                }
              },
              {
                "Name": "1-Raltegravir 400mg (granules in suspension) lsf-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg (granules in suspension)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#FF00FF",
                  "LegendIndex": 27
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              },
              {
                "Name": "1-Raltegravir 400mg filmcoated tablet-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg filmcoated tablet|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#0000FF",
                  "LegendIndex": 28
                }
              },
              {
                "Name": "1-Raltegravir 400 mg filmcoated tablet md-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#00C0C0",
                  "LegendIndex": 29
                }
              },
              {
                "Name": "1-Raltegravir 200 mg filmcoated tablet md-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 200 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#FF0000",
                  "LegendIndex": 30
                }
              },
              {
                "Name": "1-Raltegravir 100 mg filmcoated tablet md-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 100 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#FF8000",
                  "LegendIndex": 31
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              },
              {
                "Name": "1-Raltegravir 400mg chewable fed-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg chewable fed|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#C00000",
                  "LegendIndex": 32
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              },
              {
                "Name": "1-Raltegravir 400mg chewable fasted-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
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                "Y": "Raltegravir 400mg chewable fasted|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#008000",
                  "LegendIndex": 33
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              },
              {
                "Name": "2-Raltegravir 50 mg  (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 50 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#808080",
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              {
                "Name": "2-Raltegravir 400mg (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#C000C0",
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              {
                "Name": "2-Raltegravir 25 mg  (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 25 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#00FF00",
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              {
                "Name": "2-Raltegravir 200 mg   (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 200 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Color": "#8080FF",
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                "Y": "Raltegravir 1600 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#0000C0",
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              {
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                "Y": "Raltegravir 1200 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#00C000",
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              {
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                "Y": "Raltegravir 100 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#C0C000",
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                "Y": "Raltegravir 10 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#C04000",
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                "Name": "2-Raltegravir 400mg (granules in suspension) lsf-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg (granules in suspension)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Color": "#FF00FF",
                  "LegendIndex": 42
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                "Name": "2-Raltegravir 400mg filmcoated tablet-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg filmcoated tablet|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Color": "#0000FF",
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                "Y": "Raltegravir 400 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#00C0C0",
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                "X": "Time",
                "Y": "Raltegravir 200 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#FF0000",
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                "Y": "Raltegravir 100 mg filmcoated tablet md|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#FF8000",
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                "Name": "2-Raltegravir 400mg chewable fed-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg chewable fed|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#C00000",
                  "LegendIndex": 47
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              {
                "Name": "2-Raltegravir 400mg chewable fasted-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 400mg chewable fasted|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Visible": false,
                  "Color": "#008000",
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                "X": "Time",
                "Y": "Raltegravir 50 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Color": "#808080",
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                "X": "Time",
                "Y": "Raltegravir 400mg (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
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                  "Color": "#C000C0",
                  "LegendIndex": 50
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              {
                "Name": "3-Raltegravir 25 mg  (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 25 mg  (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
                "CurveOptions": {
                  "Visible": false,
                  "Color": "#00FF00",
                  "LegendIndex": 51
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              {
                "Name": "3-Raltegravir 200 mg   (lactose formulation)-Raltegravir-Peripheral Venous Blood-Plasma-Concentration",
                "X": "Time",
                "Y": "Raltegravir 200 mg   (lactose formulation)|Organism|PeripheralVenousBlood|Raltegravir|Plasma (Peripheral Venous Blood)",
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                  "Color": "#8080FF",
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      "Name": "Iwamoto 2008",
      "Classifiables": [
        "Iwamoto 2008 - 10mg - Raltegravir - PO - 10 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 25mg - Raltegravir - PO - 25 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 50mg - Raltegravir - PO - 50 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 100mg - Raltegravir - PO - 100 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 200mg - Raltegravir - PO - 200 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 400mg - Raltegravir - PO - 400 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 800mg - Raltegravir - PO - 800 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 1200mg - Raltegravir - PO - 1200 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 1600mg - Raltegravir - PO - 1600 mg - Plasma - agg. (n=24)",
        "Iwamoto 2008 - 400mg FCT - Raltegravir - PO - 400 mg - Plasma - agg. (n=14)"
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        "Rhee 2014 - granules suspension - Raltegravir - po - 400 mg - Plasma - agg. (n=12)",
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      "Name": "Markowitz 2006",
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        "Markowitz 2006 - 400mg FCT MD - Raltegravir - PO - 400 mg - Plasma - agg. (n=6)"
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            "Raltegravir 10 mg   (lactose formulation)",
            "Raltegravir 100 mg  (lactose formulation)",
            "Raltegravir 1200 mg   (lactose formulation)",
            "Raltegravir 1600 mg  (lactose formulation)",
            "Raltegravir 200 mg   (lactose formulation)",
            "Raltegravir 25 mg  (lactose formulation)",
            "Raltegravir 50 mg  (lactose formulation)",
            "Raltegravir 400mg (lactose formulation)"
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        },
        {
          "Name": "filmcoated tablet",
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            "Raltegravir 400 mg filmcoated tablet md"
          ]
        },
        {
          "Name": "Granules in suspension",
          "Classifiables": [
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        },
        {
          "Name": "chewable tablet",
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        }
      ]
    }
  ]
}