{ "Version": 80, "ExpressionProfiles": [ { "Type": "Enzyme", "Species": "Human", "Molecule": "CYP3A4", "Category": "European (P-gp modified, CYP3A4 36 h)", "Parameters": [ { "Path": "CYP3A4|Reference concentration", "Value": 4.32, "Unit": "µmol/l" }, { "Path": "CYP3A4|t1/2 (intestine)", "Value": 23.0, "Unit": "h" }, { "Path": "CYP3A4|t1/2 (liver)", "Value": 36.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" } }, { "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", "Value": 0.0041682898325 }, { "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", "Value": 0.00078691079081 }, { "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", "Value": 0.0053603428126 }, { "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression", "Value": 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"Value": 0.3971631206 }, { "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Value": 0.3971631206 }, { "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression", "Value": 0.1916810428 }, { "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression", "Value": 0.1916810428 }, { "Path": "Organism|Lung|Intracellular|P-gp|Relative expression", "Value": 0.0657549316 }, { "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression", "Value": 0.0128342959 }, { "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression", "Value": 0.0142510689 }, { "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression", "Value": 0.2808543974 }, { "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Value": 1.0 }, { "Path": 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"EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "ColonSigmoid", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Rectum", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Rectum", "TransportDirection": "EffluxMucosaIntracellularToLumen", "CompartmentName": "Intracellular" }, { "Name": "Periportal", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Periportal", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Pericentral", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Interstitial" }, { "Name": "Pericentral", "TransportDirection": "ExcretionLiver", "CompartmentName": "Intracellular" }, { "Name": "Lung", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Muscle", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Pancreas", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Skin", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "Spleen", "TransportDirection": "EffluxIntracellularToInterstitial", "CompartmentName": "Intracellular" }, { "Name": "BloodCells", "TransportDirection": "EffluxBloodCellsToPlasma" }, { "Name": "VascularEndothelium", "TransportDirection": "EffluxInterstitialToPlasma" } ], "Ontogeny": { "Name": "P-gp", "Table": { "Name": "TableFormula", "Percentile": 0.0, "DistributionMetaData": [ { "Mean": 1E-14, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 1.915059E-05, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 5.486795E-05, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.0001571905, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.0004502473, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.001288958, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.00368424, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.01048397, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.02946235, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.0800178, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.1994918, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.4165768, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.6716791, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.8542612, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.943803, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.9796414, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.992799, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.9974749, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.9991173, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.9996917, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.9998924, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.9999624, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 0.9999869, "Deviation": 1.6, "Distribution": "LogNormal" }, { "Mean": 1.0, "Deviation": 1.6, "Distribution": "LogNormal" } ], "XName": "Postmenstrual age", "XDimension": "Age in years", "XUnit": "year(s)", "YName": "P-gp", "YDimension": "Fraction", "UseDerivedValues": false, "Points": [ { "X": 0.0, "Y": 1E-14, "RestartSolver": false }, { "X": 0.08333334, "Y": 1.915059E-05, "RestartSolver": false }, { "X": 0.1666667, "Y": 5.486795E-05, "RestartSolver": false }, { "X": 0.25, "Y": 0.0001571905, "RestartSolver": false }, { "X": 0.3333333, "Y": 0.0004502473, "RestartSolver": false }, { "X": 0.4166667, "Y": 0.001288958, "RestartSolver": false }, { "X": 0.5, "Y": 0.00368424, "RestartSolver": false }, { "X": 0.5833333, "Y": 0.01048397, "RestartSolver": false }, { "X": 0.6666667, "Y": 0.02946235, "RestartSolver": false }, { "X": 0.75, "Y": 0.0800178, "RestartSolver": false }, { "X": 0.8333333, "Y": 0.1994918, "RestartSolver": false }, { "X": 0.9166667, "Y": 0.4165768, "RestartSolver": false }, { "X": 1.0, "Y": 0.6716791, "RestartSolver": false }, { "X": 1.083333, "Y": 0.8542612, "RestartSolver": false }, { "X": 1.166667, "Y": 0.943803, "RestartSolver": false }, { "X": 1.25, "Y": 0.9796414, "RestartSolver": false }, { "X": 1.333333, "Y": 0.992799, "RestartSolver": false }, { "X": 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expression", "Value": 0.0008253968254 }, { "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", "Value": 1.0 }, { "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", "Value": 4.0079365079E-05 }, { "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", "Value": 0.00064682539683 } ], "TransportType": "Influx", "Expression": [ { "Name": "Bone", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Brain", "TransportDirection": "InfluxBrainPlasmaToInterstitial", "CompartmentName": "Plasma" }, { "Name": "Brain", "TransportDirection": "InfluxBrainInterstitialToTissue", "CompartmentName": "Interstitial" }, { "Name": "Fat", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Gonads", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Heart", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Kidney", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Kidney", "TransportDirection": "ExcretionKidney", "CompartmentName": "Intracellular" }, { "Name": "Stomach", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "SmallIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Duodenum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Duodenum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerJejunum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "UpperIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "UpperIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LowerIleum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "LowerIleum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "LargeIntestine", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Intracellular" }, { "Name": "Caecum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "Caecum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonAscendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonTransversum", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxInterstitialToIntracellular", "CompartmentName": "Interstitial" }, { "Name": "ColonDescendens", "TransportDirection": "InfluxLumenToMucosaIntracellular", "CompartmentName": "Intracellular" }, { "Name": "ColonSigmoid", 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(n=2)" }, { "Scaling": "Log", "Path": "Rifampicin iv 300 mg (0.5 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "sanofi-aventis U.S. LLC. 2013 - 300 mg - Rifampicin - IV - 300 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 8.0, "Path": "Rifampicin po 600 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Peloquin 1997 - 600 mg - Rifampicin - PO - 600 mg - Plasma - agg. (n=24)" }, { "Scaling": "Log", "Weight": 15.0, "Path": "Rifampicin iv 600 mg (3 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Serum - agg. (n=6)" }, { "Scaling": "Log", "Weight": 0.75, "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|Gallbladder|Rifampicin", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Bile - agg. (n=5)" }, { "Scaling": "Log", "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Acocella 1972b - normal subjects - Rifampicin - PO - 600 mg - Urine - agg. (n=6)" }, { "Scaling": "Log", "Weight": 5.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Eon Labs Manufacturing, Inc. 1997 - 2X300mg Tab (Eon) - Rifampicin - PO - 600 mg - Plasma - agg. (n=36)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Fold-change in concentration", "ObservedData": "Greiner 1999 - CYP3A4 western blot duodenal biopsy (fold-change) - CYP3A4 - PO - 600 mg - Duodenum|Intracellular - agg. (n=8)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Fold-change in concentration", "ObservedData": "Greiner 1999 - Pg-p western blot duodenal biopsy (fold-change) - P-gp - PO - 600 mg - Duodenum|Intracellular - agg. (n=8)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Fold-change in concentration", "ObservedData": "Westphal 2000 - Pg-p western blot duodenal biopsy (fold-change) - P-gp - PO - 600 mg - Duodenum|Intracellular - agg. 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2007|EC50", "Rifampicin iv 600 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 450 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 300 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|OATP1B1-Dixit 2007|EC50" ], "Parameters": [ { "Name": "Start value", "Value": 0.34, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.0001, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 1000.0, "Unit": "µmol/l" } ] }, { "Name": "Solubility at reference pH", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|Solubility at reference pH", "Rifampicin po 450 mg|Rifampicin|Solubility at reference pH", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|Solubility at reference pH", "Rifampicin po 600 mg|Rifampicin|Solubility at reference pH", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|Solubility at reference pH", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|Solubility at reference pH", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|Solubility at reference pH", "Rifampicin iv 600 mg (3 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 450 mg (3 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 300 mg (3 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|Solubility at reference pH" ], "Parameters": [ { "Name": "Start value", "Value": 2800.0, "Unit": "mg/l" }, { "Name": "MinValue", "Value": 45.0, "Unit": "mg/l" }, { "Name": "MaxValue", "Value": 4500.0, "Unit": "mg/l" } ] }, { "Name": "Fraction unbound (plasma, reference value)", "Scaling": "Linear", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 450 mg|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 600 mg|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 600 mg (3 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 450 mg (3 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 300 mg (3 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|Fraction unbound (plasma, reference value)" ], "Parameters": [ { "Name": "Start value", "Value": 17.0, "Unit": "%" }, { "Name": "MinValue", "Value": 1.1, "Unit": "%" }, { "Name": "MaxValue", "Value": 100.0, "Unit": "%" } ] }, { "Name": "Reference pH", "Scaling": "Linear", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|Reference pH", "Rifampicin po 450 mg|Rifampicin|Reference pH", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|Reference pH", "Rifampicin po 600 mg|Rifampicin|Reference pH", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|Reference pH", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|Reference pH", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|Reference pH", "Rifampicin iv 600 mg (3 h)|Rifampicin|Reference pH", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|Reference pH", "Rifampicin iv 450 mg (3 h)|Rifampicin|Reference pH", "Rifampicin iv 300 mg (3 h)|Rifampicin|Reference pH", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|Reference pH" ], "Parameters": [ { "Name": "Start value", "Value": 7.5 }, { "Name": "MinValue", "Value": 0.0 }, { "Name": "MaxValue", "Value": 14.0 } ] }, { "Name": "Ref conc P-gp", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|P-gp|Reference concentration", "Rifampicin po 450 mg|P-gp|Reference concentration", "Rifampicin po 450 mg MD OD (7 days)|P-gp|Reference concentration", "Rifampicin po 600 mg|P-gp|Reference concentration", "Rifampicin po 600 mg MD OD (7 days)|P-gp|Reference concentration", "Rifampicin po 600 mg MD OD (16 days)|P-gp|Reference concentration", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|P-gp|Reference concentration", "Rifampicin iv 600 mg (3 h)|P-gp|Reference concentration", "Rifampicin iv 600 mg (0.5 h)|P-gp|Reference concentration", "Rifampicin iv 450 mg (3 h)|P-gp|Reference concentration", "Rifampicin iv 300 mg (3 h)|P-gp|Reference concentration", "Rifampicin iv 300 mg (0.5 h)|P-gp|Reference concentration" ], "Parameters": [ { "Name": "Start value", "Value": 1.41, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.1, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 14.1, "Unit": "µmol/l" } ] }, { "Name": "Ref conc OATP1B1", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|OATP1B1|Reference concentration", "Rifampicin po 450 mg|OATP1B1|Reference concentration", "Rifampicin po 450 mg MD OD (7 days)|OATP1B1|Reference concentration", "Rifampicin po 600 mg|OATP1B1|Reference concentration", "Rifampicin po 600 mg MD OD (7 days)|OATP1B1|Reference concentration", "Rifampicin po 600 mg MD OD (16 days)|OATP1B1|Reference concentration", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|OATP1B1|Reference concentration", "Rifampicin iv 600 mg (3 h)|OATP1B1|Reference concentration", "Rifampicin iv 600 mg (0.5 h)|OATP1B1|Reference concentration", "Rifampicin iv 450 mg (3 h)|OATP1B1|Reference concentration", "Rifampicin iv 300 mg (3 h)|OATP1B1|Reference concentration", "Rifampicin iv 300 mg (0.5 h)|OATP1B1|Reference concentration" ], "Parameters": [ { "Name": "Start value", "Value": 1.0, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.1, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 10.0, "Unit": "µmol/l" } ] }, { "Name": "Relative expression P-gp Mucosa", "Scaling": "Linear", "UseAsFactor": true, "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression" ], "Parameters": [ { "Name": "Start value", "Value": 1.0 }, { "Name": "MinValue", "Value": 0.1 }, { "Name": "MaxValue", "Value": 10.0 } ] } ] }, { "Name": "PI Hanke et al. 2018 (original start values)", "Simulations": [ "Rifampicin po 300 mg", "Rifampicin po 450 mg", "Rifampicin po 450 mg MD OD (7 days)", "Rifampicin po 600 mg", "Rifampicin po 600 mg MD OD (7 days)", "Rifampicin po 600 mg MD OD (16 days)", "Rifampicin iv 600 mg (3 h) MD OD (7 days)", "Rifampicin iv 600 mg (3 h)", "Rifampicin iv 600 mg (0.5 h)", "Rifampicin iv 450 mg (3 h)", "Rifampicin iv 300 mg (3 h)", "Rifampicin iv 300 mg (0.5 h)" ], "Configuration": { "LLOQMode": "SimulationOutputAsObservedDataLLOQ", "RemoveLLOQMode": "Never", "CalculateJacobian": false, "Algorithm": { "Name": "Levenberg - Marquardt (MPFit)", "Properties": [ { "Name": "ftol", "Value": 0.001, "Type": "Double" }, { "Name": "xtol", "Value": 1E-06, "Type": "Double" }, { "Name": "gtol", "Value": 1E-10, "Type": "Double" }, { "Name": "stepfactor", "Value": 100.0, "Type": "Double" }, { "Name": "maxiter", "Value": 200.0, "Type": "Double" }, { "Name": "maxfev", "Value": 0.0, "Type": "Double" }, { "Name": "epsfcn", "Value": 1E-09, "Type": "Double" } ] } }, "OutputMappings": [ { "Scaling": "Log", "Path": "Rifampicin po 300 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Chouchane 1995 - Rifampicin Generic - Rifampicin - PO - 300 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 300 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Chouchane 1995 - Rimactan - Rifampicin - PO - 300 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 300 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Furesz 1970 - 300 mg - Rifampicin - PO - 300 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.75, "Path": "Rifampicin po 450 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Blume 1989 - 450 mg REFERENZ - Rifampicin - PO - 450 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 450 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 450 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Furesz 1970 - 450 mg - Rifampicin - PO - 450 mg - Serum - agg. (n=13)" }, { "Scaling": "Log", "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972a - day 7 - Rifampicin - PO - 450 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.75, "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Urine - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Peloquin 1997 - 600 mg - Rifampicin - PO - 600 mg - Plasma - agg. (n=24)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Eon Labs Manufacturing, Inc. 1997 - 2X300mg Rifadine Tab - Rifampicin - PO - 600 mg - Plasma - agg. (n=36)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Blume 1989 - 600 mg REFERENZ - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972b - normal subjects - Rifampicin - PO - 600 mg - Serum - agg. (n=6)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Furesz 1970 - 600 mg - Rifampicin - PO - 600 mg - Serum - agg. (n=12)" }, { "Scaling": "Log", "Weight": 30.0, "Path": "Rifampicin po 600 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Baneyx 2014 - Day 4 - 600 mg po MD - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 30.0, "Path": "Rifampicin po 600 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Baneyx 2014 - Day 7 - 600 mg po MD - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Serum - agg. (n=6)" }, { "Scaling": "Log", "Weight": 5.0, "Path": "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1977 - mean 600 mg MD - Rifampicin - IV - 600 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Path": "Rifampicin iv 600 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Urine - agg. (n=6)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin iv 600 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Acocella 1977 - mean 600 mg MD - Rifampicin - IV - 600 mg - Urine - agg. (n=5)" }, { "Scaling": "Log", "Path": "Rifampicin iv 600 mg (0.5 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "sanofi-aventis U.S. LLC. 2013 - 600 mg - Rifampicin - IV - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Path": "Rifampicin iv 450 mg (3 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 450 mg - Rifampicin - IV - 450 mg - Serum - agg. (n=3)" }, { "Scaling": "Log", "Path": "Rifampicin iv 450 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Nitti 1977 - 450 mg - Rifampicin - IV - 450 mg - Urine - agg. (n=3)" }, { "Scaling": "Log", "Path": "Rifampicin iv 300 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Nitti 1977 - 300 mg - Rifampicin - IV - 300 mg - Urine - agg. (n=2)" }, { "Scaling": "Log", "Path": "Rifampicin iv 300 mg (3 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 300 mg - Rifampicin - IV - 300 mg - Serum - agg. (n=2)" }, { "Scaling": "Log", "Path": "Rifampicin iv 300 mg (0.5 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "sanofi-aventis U.S. LLC. 2013 - 300 mg - Rifampicin - IV - 300 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 8.0, "Path": "Rifampicin po 600 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Peloquin 1997 - 600 mg - Rifampicin - PO - 600 mg - Plasma - agg. (n=24)" }, { "Scaling": "Log", "Weight": 15.0, "Path": "Rifampicin iv 600 mg (3 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Serum - agg. (n=6)" }, { "Scaling": "Log", "Weight": 0.75, "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|Gallbladder|Rifampicin", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Bile - agg. (n=5)" }, { "Scaling": "Log", "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Acocella 1972b - normal subjects - Rifampicin - PO - 600 mg - Urine - agg. (n=6)" }, { "Scaling": "Log", "Weight": 5.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Eon Labs Manufacturing, Inc. 1997 - 2X300mg Tab (Eon) - Rifampicin - PO - 600 mg - Plasma - agg. 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"Rifampicin iv 450 mg (3 h)|Rifampicin|P-gp-Greiner 1999|EC50", "Rifampicin iv 300 mg (3 h)|Rifampicin|P-gp-Greiner 1999|EC50", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|P-gp-Greiner 1999|EC50" ], "Parameters": [ { "Name": "Start value", "Value": 0.34, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.0001, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 1000.0, "Unit": "µmol/l" } ] }, { "Name": "Esterase Emax", "Scaling": "Log", "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|AADAC-Assumed|Emax", "Rifampicin po 450 mg|Rifampicin|AADAC-Assumed|Emax", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin po 600 mg|Rifampicin|AADAC-Assumed|Emax", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin iv 600 mg (3 h)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin iv 450 mg (3 h)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin iv 300 mg (3 h)|Rifampicin|AADAC-Assumed|Emax", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|AADAC-Assumed|Emax" ], "Parameters": [ { "Name": "Start value", "Value": 1.02 }, { "Name": "MinValue", "Value": 0.1 }, { "Name": "MaxValue", "Value": 100.0 } ] }, { "Name": "Esterase EC50", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|AADAC-Assumed|EC50", "Rifampicin po 450 mg|Rifampicin|AADAC-Assumed|EC50", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin po 600 mg|Rifampicin|AADAC-Assumed|EC50", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin iv 600 mg (3 h)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin iv 450 mg (3 h)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin iv 300 mg (3 h)|Rifampicin|AADAC-Assumed|EC50", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|AADAC-Assumed|EC50" ], "Parameters": [ { "Name": "Start value", "Value": 0.34, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.0001, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 1000.0, "Unit": "µmol/l" } ] }, { "Name": "OATP Emax", "Scaling": "Log", "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin po 450 mg|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin po 600 mg|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin iv 600 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin iv 450 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin iv 300 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|Emax", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|OATP1B1-Dixit 2007|Emax" ], "Parameters": [ { "Name": "Start value", "Value": 0.71 }, { "Name": "MinValue", "Value": 0.1 }, { "Name": "MaxValue", "Value": 100.0 } ] }, { "Name": "OATP EC50", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin po 450 mg|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin po 600 mg|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 600 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 450 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 300 mg (3 h)|Rifampicin|OATP1B1-Dixit 2007|EC50", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|OATP1B1-Dixit 2007|EC50" ], "Parameters": [ { "Name": "Start value", "Value": 0.34, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.0001, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 1000.0, "Unit": "µmol/l" } ] }, { "Name": "Solubility at reference pH", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|Solubility at reference pH", "Rifampicin po 450 mg|Rifampicin|Solubility at reference pH", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|Solubility at reference pH", "Rifampicin po 600 mg|Rifampicin|Solubility at reference pH", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|Solubility at reference pH", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|Solubility at reference pH", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|Solubility at reference pH", "Rifampicin iv 600 mg (3 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 450 mg (3 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 300 mg (3 h)|Rifampicin|Solubility at reference pH", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|Solubility at reference pH" ], "Parameters": [ { "Name": "Start value", "Value": 2800.0, "Unit": "mg/l" }, { "Name": "MinValue", "Value": 45.0, "Unit": "mg/l" }, { "Name": "MaxValue", "Value": 4500.0, "Unit": "mg/l" } ] }, { "Name": "Fraction unbound (plasma, reference value)", "Scaling": "Linear", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 450 mg|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 600 mg|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 600 mg (3 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 450 mg (3 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 300 mg (3 h)|Rifampicin|Fraction unbound (plasma, reference value)", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|Fraction unbound (plasma, reference value)" ], "Parameters": [ { "Name": "Start value", "Value": 17.0, "Unit": "%" }, { "Name": "MinValue", "Value": 1.1, "Unit": "%" }, { "Name": "MaxValue", "Value": 100.0, "Unit": "%" } ] }, { "Name": "Reference pH", "Scaling": "Linear", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Rifampicin|Reference pH", "Rifampicin po 450 mg|Rifampicin|Reference pH", "Rifampicin po 450 mg MD OD (7 days)|Rifampicin|Reference pH", "Rifampicin po 600 mg|Rifampicin|Reference pH", "Rifampicin po 600 mg MD OD (7 days)|Rifampicin|Reference pH", "Rifampicin po 600 mg MD OD (16 days)|Rifampicin|Reference pH", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Rifampicin|Reference pH", "Rifampicin iv 600 mg (3 h)|Rifampicin|Reference pH", "Rifampicin iv 600 mg (0.5 h)|Rifampicin|Reference pH", "Rifampicin iv 450 mg (3 h)|Rifampicin|Reference pH", "Rifampicin iv 300 mg (3 h)|Rifampicin|Reference pH", "Rifampicin iv 300 mg (0.5 h)|Rifampicin|Reference pH" ], "Parameters": [ { "Name": "Start value", "Value": 7.5 }, { "Name": "MinValue", "Value": 0.0 }, { "Name": "MaxValue", "Value": 14.0 } ] }, { "Name": "Ref conc P-gp", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|P-gp|Reference concentration", "Rifampicin po 450 mg|P-gp|Reference concentration", "Rifampicin po 450 mg MD OD (7 days)|P-gp|Reference concentration", "Rifampicin po 600 mg|P-gp|Reference concentration", "Rifampicin po 600 mg MD OD (7 days)|P-gp|Reference concentration", "Rifampicin po 600 mg MD OD (16 days)|P-gp|Reference concentration", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|P-gp|Reference concentration", "Rifampicin iv 600 mg (3 h)|P-gp|Reference concentration", "Rifampicin iv 600 mg (0.5 h)|P-gp|Reference concentration", "Rifampicin iv 450 mg (3 h)|P-gp|Reference concentration", "Rifampicin iv 300 mg (3 h)|P-gp|Reference concentration", "Rifampicin iv 300 mg (0.5 h)|P-gp|Reference concentration" ], "Parameters": [ { "Name": "Start value", "Value": 1.41, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.1, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 14.1, "Unit": "µmol/l" } ] }, { "Name": "Ref conc OATP1B1", "Scaling": "Log", "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|OATP1B1|Reference concentration", "Rifampicin po 450 mg|OATP1B1|Reference concentration", "Rifampicin po 450 mg MD OD (7 days)|OATP1B1|Reference concentration", "Rifampicin po 600 mg|OATP1B1|Reference concentration", "Rifampicin po 600 mg MD OD (7 days)|OATP1B1|Reference concentration", "Rifampicin po 600 mg MD OD (16 days)|OATP1B1|Reference concentration", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|OATP1B1|Reference concentration", "Rifampicin iv 600 mg (3 h)|OATP1B1|Reference concentration", "Rifampicin iv 600 mg (0.5 h)|OATP1B1|Reference concentration", "Rifampicin iv 450 mg (3 h)|OATP1B1|Reference concentration", "Rifampicin iv 300 mg (3 h)|OATP1B1|Reference concentration", "Rifampicin iv 300 mg (0.5 h)|OATP1B1|Reference concentration" ], "Parameters": [ { "Name": "Start value", "Value": 1.0, "Unit": "µmol/l" }, { "Name": "MinValue", "Value": 0.1, "Unit": "µmol/l" }, { "Name": "MaxValue", "Value": 10.0, "Unit": "µmol/l" } ] }, { "Name": "Relative expression P-gp Mucosa", "Scaling": "Linear", "UseAsFactor": true, "IsFixed": true, "LinkedParameters": [ "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 300 mg|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 450 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin po 600 mg MD OD (16 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 600 mg (0.5 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 450 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (3 h)|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 h)|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression", "Rifampicin iv 300 mg (0.5 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"Name": "maxfev", "Value": 0.0, "Type": "Double" }, { "Name": "epsfcn", "Value": 1E-09, "Type": "Double" } ] } }, "OutputMappings": [ { "Scaling": "Log", "Path": "Rifampicin po 300 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Chouchane 1995 - Rifampicin Generic - Rifampicin - PO - 300 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 300 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Chouchane 1995 - Rimactan - Rifampicin - PO - 300 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 300 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Furesz 1970 - 300 mg - Rifampicin - PO - 300 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.75, "Path": "Rifampicin po 450 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Blume 1989 - 450 mg REFERENZ - Rifampicin - PO - 450 mg - Plasma - agg. (n=8)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 450 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 450 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Furesz 1970 - 450 mg - Rifampicin - PO - 450 mg - Serum - agg. (n=13)" }, { "Scaling": "Log", "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972a - day 7 - Rifampicin - PO - 450 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.75, "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Urine - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Peloquin 1997 - 600 mg - Rifampicin - PO - 600 mg - Plasma - agg. (n=24)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Eon Labs Manufacturing, Inc. 1997 - 2X300mg Rifadine Tab - Rifampicin - PO - 600 mg - Plasma - agg. (n=36)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Blume 1989 - 600 mg REFERENZ - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972b - normal subjects - Rifampicin - PO - 600 mg - Serum - agg. (n=6)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Furesz 1970 - 600 mg - Rifampicin - PO - 600 mg - Serum - agg. (n=12)" }, { "Scaling": "Log", "Weight": 10.0, "Path": "Rifampicin po 600 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Baneyx 2014 - Day 4 - 600 mg po MD - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 10.0, "Path": "Rifampicin po 600 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Baneyx 2014 - Day 7 - 600 mg po MD - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Serum - agg. (n=6)" }, { "Scaling": "Log", "Weight": 5.0, "Path": "Rifampicin iv 600 mg (3 h) MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1977 - mean 600 mg MD - Rifampicin - IV - 600 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Path": "Rifampicin iv 600 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Urine - agg. (n=6)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin iv 600 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Acocella 1977 - mean 600 mg MD - Rifampicin - IV - 600 mg - Urine - agg. (n=5)" }, { "Scaling": "Log", "Path": "Rifampicin iv 600 mg (0.5 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "sanofi-aventis U.S. LLC. 2013 - 600 mg - Rifampicin - IV - 600 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Path": "Rifampicin iv 450 mg (3 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 450 mg - Rifampicin - IV - 450 mg - Serum - agg. (n=3)" }, { "Scaling": "Log", "Path": "Rifampicin iv 450 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Nitti 1977 - 450 mg - Rifampicin - IV - 450 mg - Urine - agg. (n=3)" }, { "Scaling": "Log", "Path": "Rifampicin iv 300 mg (3 h)|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Nitti 1977 - 300 mg - Rifampicin - IV - 300 mg - Urine - agg. (n=2)" }, { "Scaling": "Log", "Path": "Rifampicin iv 300 mg (3 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 300 mg - Rifampicin - IV - 300 mg - Serum - agg. (n=2)" }, { "Scaling": "Log", "Path": "Rifampicin iv 300 mg (0.5 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "sanofi-aventis U.S. LLC. 2013 - 300 mg - Rifampicin - IV - 300 mg - Plasma - agg. (n=12)" }, { "Scaling": "Log", "Weight": 8.0, "Path": "Rifampicin po 600 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Peloquin 1997 - 600 mg - Rifampicin - PO - 600 mg - Plasma - agg. (n=24)" }, { "Scaling": "Log", "Weight": 15.0, "Path": "Rifampicin iv 600 mg (3 h)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Serum - agg. (n=6)" }, { "Scaling": "Log", "Weight": 0.75, "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|Gallbladder|Rifampicin", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Bile - agg. (n=5)" }, { "Scaling": "Log", "Path": "Rifampicin po 450 mg MD OD (7 days)|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Acocella 1972a - day 1 - Rifampicin - PO - 450 mg - Serum - agg. (n=5)" }, { "Scaling": "Log", "Weight": 0.0, "Path": "Rifampicin po 600 mg|Organism|Kidney|Urine|Rifampicin", "ObservedData": "Acocella 1972b - normal subjects - Rifampicin - PO - 600 mg - Urine - agg. (n=6)" }, { "Scaling": "Log", "Weight": 5.0, "Path": "Rifampicin po 600 mg|Organism|PeripheralVenousBlood|Rifampicin|Plasma (Peripheral Venous Blood)", "ObservedData": "Eon Labs Manufacturing, Inc. 1997 - 2X300mg Tab (Eon) - Rifampicin - PO - 600 mg - Plasma - agg. 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(n=5)", "Acocella 1977 - Subject 14 (600 mg MD) - Rifampicin - IV - 600 mg - Urine - indiv.", "Acocella 1977 - Subject 13 (600 mg MD) - Rifampicin - IV - 600 mg - Urine - indiv.", "Acocella 1977 - Subject 12 (600 mg MD) - Rifampicin - IV - 600 mg - Urine - indiv.", "Acocella 1977 - Subject 11 (600 mg MD) - Rifampicin - IV - 600 mg - Urine - indiv.", "Acocella 1977 - Subject 10 (600 mg MD) - Rifampicin - IV - 600 mg - Urine - indiv.", "Acocella 1977 - mean 600 mg MD - Rifampicin - IV - 600 mg - Serum - agg. (n=5)", "Acocella 1977 - Subject 14 (600 mg MD) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1977 - Subject 13 (600 mg MD) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1977 - Subject 11 (600 mg MD) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1977 - Subject 10 (600 mg MD) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1977 - Subject 9 (600 mg) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1977 - Subject 8 (600 mg) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1977 - Subject 7 (600 mg) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1977 - Subject 6 (450 mg) - Rifampicin - IV - 450 mg - Serum - indiv.", "Acocella 1977 - Subject 5 (450 mg) - Rifampicin - IV - 450 mg - Serum - indiv.", "Acocella 1977 - Subject 4 (300 mg) - Rifampicin - IV - 300 mg - Serum - indiv.", "Acocella 1977 - Subject 3 (300 mg) - Rifampicin - IV - 300 mg - Serum - indiv.", "Acocella 1977 - Subject 2 (150 mg) - Rifampicin - IV - 150 mg - Serum - indiv.", "Acocella 1977 - Subject 1 (150 mg) - Rifampicin - IV - 150 mg - Serum - indiv.", "Acocella 1977 - Subject 12 (600 mg MD) - Rifampicin - IV - 600 mg - Serum - indiv." ] }, { "Name": "Acocella 1984", "Classifiables": [ "Acocella 1984 - Individual 18 (1200 mg, 1 h infusion) - Rifampicin - IV - 1200 mg - Serum - indiv.", "Acocella 1984 - Individual 17 (1200 mg, 1 h infusion) - Rifampicin - IV - 1200 mg - Serum - indiv.", "Acocella 1984 - Individual 16 (1200 mg, 2 h infusion) - Rifampicin - IV - 1200 mg - Serum - indiv.", "Acocella 1984 - Individual 15 (1200 mg, 2 h infusion) - Rifampicin - IV - 1200 mg - Serum - indiv.", "Acocella 1984 - Individual 14 (1200 mg, 3 h infusion) - Rifampicin - IV - 1200 mg - Serum - indiv.", "Acocella 1984 - Individual 13 (1200 mg, 3 h infusion) - Rifampicin - IV - 1200 mg - Serum - indiv.", "Acocella 1984 - Individual 12 (900 mg, 1 h infusion) - Rifampicin - IV - 900 mg - Serum - indiv.", "Acocella 1984 - Individual 11 (900 mg, 1 h infusion) - Rifampicin - IV - 900 mg - Serum - indiv.", "Acocella 1984 - Individual 10 (900 mg, 2 h infusion) - Rifampicin - IV - 900 mg - Serum - indiv.", "Acocella 1984 - Individual 9 (900 mg, 2 h infusion) - Rifampicin - IV - 900 mg - Serum - indiv.", "Acocella 1984 - Individual 8 (900 mg, 3 h infusion) - Rifampicin - IV - 900 mg - Serum - indiv.", "Acocella 1984 - Individual 7 (900 mg, 3 h infusion) - Rifampicin - IV - 900 mg - Serum - indiv.", "Acocella 1984 - Individual 6 (600 mg, 1 h infusion) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1984 - Individual 5 (600 mg, 1 h infusion) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1984 - Individual 4 (600 mg, 2 h infusion) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1984 - Individual 3 (600 mg, 2 h infusion) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1984 - Individual 2 (600 mg, 3 h infusion) - Rifampicin - IV - 600 mg - Serum - indiv.", "Acocella 1984 - Individual 1 (600 mg, 3 h infusion) - Rifampicin - IV - 600 mg - Serum - indiv." ] }, { "Name": "Baneyx 2014", "Classifiables": [ "Baneyx 2014 - Day 4 - 600 mg po MD - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)", "Baneyx 2014 - Day 7 - 600 mg po MD - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)" ] }, { "Name": "Blume 1989", "Classifiables": [ "Blume 1989 - 600 mg REFERENZ - Rifampicin - PO - 600 mg - Plasma - agg. (n=12)", "Blume 1989 - 450 mg REFERENZ - Rifampicin - PO - 450 mg - Plasma - agg. (n=8)" ] }, { "Name": "Burger 2006", "Classifiables": [ "Burger 2006 - Rifampin alone - Rifampicin - PO - 600 mg - Plasma - agg. (n=14)" ] }, { "Name": "Chouchane 1995", "Classifiables": [ "Chouchane 1995 - Rifampicin Generic - Rifampicin - PO - 300 mg - Plasma - agg. (n=12)", "Chouchane 1995 - Rimactan - Rifampicin - PO - 300 mg - Plasma - agg. (n=12)" ] }, { "Name": "Eon Labs Manufacturing, Inc. 1997", "Classifiables": [ "Eon Labs Manufacturing, Inc. 1997 - 2X300mg Rifadine Tab - Rifampicin - PO - 600 mg - Plasma - agg. (n=36)", "Eon Labs Manufacturing, Inc. 1997 - 2X300mg Tab (Eon) - Rifampicin - PO - 600 mg - Plasma - agg. (n=36)" ] }, { "Name": "Loos 1985", "Classifiables": [ "Loos 1985 - iv day 22 (Patient 4) - Rifampicin - IV/PO - 600 mg - Serum - indiv.", "Loos 1985 - iv day 8 (Patient 4) - Rifampicin - IV/PO - 600 mg - Serum - indiv.", "Loos 1985 - iv day 1 (Patient 4) - Rifampicin - IV - 600 mg - Serum - indiv.", "Loos 1985 - oral day 23 (Patient 4) - Rifampicin - IV/PO - 600 mg - Serum - indiv.", "Loos 1985 - oral day 9 (Patient 4) - Rifampicin - IV/PO - 600 mg - Serum - indiv.", "Loos 1985 - oral day 2 (Patient 4) - Rifampicin - IV/PO - 600 mg - Serum - indiv." ] }, { "Name": "Nitti 1977", "Classifiables": [ "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Urine - agg. (n=6)", "Nitti 1977 - 450 mg - Rifampicin - IV - 450 mg - Urine - agg. (n=3)", "Nitti 1977 - 300 mg - Rifampicin - IV - 300 mg - Urine - agg. (n=2)", "Nitti 1977 - 600 mg - Rifampicin - IV - 600 mg - Serum - agg. (n=6)", "Nitti 1977 - 450 mg - Rifampicin - IV - 450 mg - Serum - agg. (n=3)", "Nitti 1977 - 300 mg - Rifampicin - IV - 300 mg - Serum - agg. (n=2)" ] }, { "Name": "Peloquin 1997", "Classifiables": [ "Peloquin 1997 - 600 mg - Rifampicin - PO - 600 mg - Plasma - agg. (n=24)" ] }, { "Name": "Peloquin 1999", "Classifiables": [ "Peloquin 1999 - fast1 - Rifampicin - PO - 600 mg - Serum - agg. (n=14)", "Peloquin 1999 - fast2 - Rifampicin - PO - 600 mg - Serum - agg. (n=14)", "Peloquin 1999 - antacid - Rifampicin - PO - 600 mg - Serum - agg. (n=14)", "Peloquin 1999 - fed - Rifampicin - PO - 600 mg - Serum - agg. (n=14)" ] }, { "Name": "sanofi-aventis U.S. LLC. 2013", "Classifiables": [ "sanofi-aventis U.S. LLC. 2013 - 300 mg - Rifampicin - IV - 300 mg - Plasma - agg. (n=12)", "sanofi-aventis U.S. LLC. 2013 - 600 mg - Rifampicin - IV - 600 mg - Plasma - agg. (n=12)" ] }, { "Name": "Stone 2004", "Classifiables": [ "Stone 2004 - Day 14 of Rifampin alone - Rifampicin - PO - 600 mg - Plasma - agg. (n=26)" ] }, { "Name": "Acocella 1985", "Classifiables": [ "Acocella 1985 - R alone - Rifampicin - PO - 10 mg/kg - Plasma - agg. (n=4)" ] }, { "Name": "Furesz 1970", "Classifiables": [ "Furesz 1970 - 100 mg - Rifampicin - PO - 100 mg - Serum - agg. (n=6)", "Furesz 1970 - 150 mg - Rifampicin - PO - 150 mg - Serum - agg. (n=27)", "Furesz 1970 - 250 mg - Rifampicin - PO - 250 mg - Serum - agg. (n=10)", "Furesz 1970 - 300 mg - Rifampicin - PO - 300 mg - Serum - agg. (n=5)", "Furesz 1970 - 450 mg - Rifampicin - PO - 450 mg - Serum - agg. (n=13)", "Furesz 1970 - 600 mg - Rifampicin - PO - 600 mg - Serum - agg. (n=12)", "Furesz 1970 - 750 mg - Rifampicin - PO - 750 mg - Serum - agg. (n=10)", "Furesz 1970 - 900 mg - Rifampicin - PO - 900 mg - Serum - agg. (n=9)" ] }, { "Name": "Greiner 1999", "Classifiables": [ "Greiner 1999 - CYP3A4 western blot duodenal biopsy (fold-change) - CYP3A4 - PO - 600 mg - Duodenum|Intracellular - agg. (n=8)", "Greiner 1999 - Pg-p western blot duodenal biopsy (fold-change) - P-gp - PO - 600 mg - Duodenum|Intracellular - agg. (n=8)" ] }, { "Name": "Westphal 2000", "Classifiables": [ "Westphal 2000 - Pg-p western blot duodenal biopsy (fold-change) - P-gp - PO - 600 mg - Duodenum|Intracellular - agg. (n=8)" ] }, { "Name": "Chattopadhyay 2018", "Classifiables": [ "Chattopadhyay 2018 - Rifampicin - Rifampicin - PO - 600 mg - Plasma - agg. (n=11)" ] } ], "SimulationClassifications": [ { "Name": "iv", "Classifiables": [ "Rifampicin iv 600 mg (3 h) MD OD (7 days)", "Rifampicin iv 300 mg (0.5 h)", "Rifampicin iv 300 mg (3 h)", "Rifampicin iv 450 mg (3 h)", "Rifampicin iv 600 mg (0.5 h)", "Rifampicin iv 600 mg (3 h)" ] }, { "Name": "po", "Classifiables": [ "Rifampicin po 600 mg MD OD (7 days)", "Rifampicin po 300 mg", "Rifampicin po 450 mg", "Rifampicin po 600 mg", "Rifampicin po 450 mg MD OD (7 days)", "Rifampicin po 600 mg MD OD (16 days)", "Rifampicin po 600 mg Chattopadhyay 2018" ] } ] }