{
  "Version": 78,
  "Individuals": [
    {
      "Name": "European (P-gp modified, CYP3A4 36 h)",
      "Seed": 17189110,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "GABRG2|Reference concentration",
          "Value": 1.04099689,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "GABRG2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "GABRG2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Bone|Intracellular|P-gp|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Brain|Intracellular|GABRG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Brain|Intracellular|P-gp|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Heart|Intracellular|P-gp|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Lung|Intracellular|P-gp|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        },
        {
          "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "P-gp|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "P-gp|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "P-gp|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A4|Reference concentration",
          "Value": 2.32,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "UGT1A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "P-gp",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        },
        {
          "Name": "UGT1A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "UGT1A4"
          }
        },
        {
          "Name": "GABRG2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        }
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Triazolam",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "Optimized",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 1.897007419,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.174,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVivo",
                "Description": "PMID: 3360971"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 4.53,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "Unknown",
                "Description": "drugbank.ca"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 7.0,
              "ValueOrigin": {
                "Source": "Unknown",
                "Description": "drugbank.ca"
              }
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Optimized",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 7.0220146601E-05,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 1.52,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "alpha-OH pathway",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 2.36,
              "Unit": "nmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 8632299"
              }
            },
            {
              "Name": "Km",
              "Value": 74.2,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 8632299"
              }
            },
            {
              "Name": "kcat",
              "Value": 4.0317206142,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "4-OH pathway",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 10.27,
              "Unit": "nmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 8632299"
              }
            },
            {
              "Name": "Km",
              "Value": 305.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 8632299"
              }
            },
            {
              "Name": "kcat",
              "Value": 17.5448180963,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Cl",
          "Value": 2.0
        },
        {
          "Name": "Molecular weight",
          "Value": 343.21,
          "Unit": "g/mol"
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "Halcion",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 1.7958147418,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 2.5169993312,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    }
  ],
  "Protocols": [
    {
      "Name": "IV_0.125mg",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.125,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 1.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_0.25mg",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.25,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 1.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_0.5mg",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.5,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 1.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_0.75mg",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.75,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 1.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "IV_1mg",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 1.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "PO_0.125mg",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.125,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "PO_0.25mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 0.25,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "PO_0.5mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
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        {
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          }
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        {
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        {
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          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)",
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          }
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        {
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        },
        {
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        {
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      ],
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              "MoleculeName": "CYP3A4"
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      ]
    },
    {
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        {
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        {
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        {
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        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)",
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        {
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        },
        {
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          }
        },
        {
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        {
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          }
        },
        {
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      ],
      "OutputSelections": [
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      "Individual": "European (P-gp modified, CYP3A4 36 h)",
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            {
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          ],
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              {
                "Name": "Halcion",
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      ],
      "HasResults": true,
      "IndividualAnalyses": [
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              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "mg/l",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "Min": 0.0001,
              "Max": 0.00151705,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Log",
              "NumberMode": "Normal"
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          ],
          "Curves": [
            {
              "Name": "PO_0.125mg-Triazolam-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "PO_0.125mg|Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "LegendIndex": 1
              }
            },
            {
              "Name": "Moltke 1996 - Triazolam + Placebo (Trial 2) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=9)-Triazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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              "Y": "Moltke 1996 - Triazolam + Placebo (Trial 2) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
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                "LegendIndex": 3,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Greenblatt 1991 - Young subjects, 0.125 mg - Triazolam - PO - 0.125 mg - Plasma - agg. (n=26)-Triazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Greenblatt 1991 - Young subjects, 0.125 mg - Triazolam - PO - 0.125 mg - Plasma - agg. (n=26)|Time",
              "Y": "Greenblatt 1991 - Young subjects, 0.125 mg - Triazolam - PO - 0.125 mg - Plasma - agg. (n=26)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#FF0000",
                "LegendIndex": 2,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            }
          ],
          "Name": "Time Profile Analysis",
          "Settings": {
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            "LegendPosition": "None",
            "BackColor": "#FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Triazolam\nPO_0.125mg\n2019-10-29 09:05"
        },
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
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              "GridLines": false,
              "Visible": true,
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              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
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              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
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            }
          ],
          "Curves": [
            {
              "Name": "PO_0.125mg-Triazolam-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "PO_0.125mg|Organism|PeripheralVenousBlood|Triazolam|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
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            },
            {
              "Name": "Greenblatt 1991 - Young subjects, 0.125 mg - Triazolam - PO - 0.125 mg - Plasma - agg. (n=26)-Triazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Greenblatt 1991 - Young subjects, 0.125 mg - Triazolam - PO - 0.125 mg - Plasma - agg. (n=26)|Time",
              "Y": "Greenblatt 1991 - Young subjects, 0.125 mg - Triazolam - PO - 0.125 mg - Plasma - agg. (n=26)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#FF0000",
                "LegendIndex": 5,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Moltke 1996 - Triazolam + Placebo (Trial 2) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=9)-Triazolam-Peripheral Venous Blood-Plasma-ArithmeticMean",
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              "Y": "Moltke 1996 - Triazolam + Placebo (Trial 2) - Triazolam - PO - 0.125 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
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                "LegendIndex": 7,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            }
          ],
          "Name": "Time Profile Analysis 1",
          "Settings": {
            "SideMarginsEnabled": true,
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            "BackColor": "#FFFFFF",
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          },
          "OriginText": "Triazolam\nPO_0.125mg\n2019-10-29 09:05"
        }
      ]
    },
    {
      "Name": "PO_0.25mg",
      "Model": "4Comp",
      "ObservedData": [
        "Varhe 1996c - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)",
        "Varhe 1996b - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)",
        "Varhe 1996a - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)",
        "Varhe 1994 - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=9)",
        "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - PO - 0.25 mg - Plasma - agg. (n=18)",
        "Lilja 2000 - Triazolam with 200 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)",
        "Kroboth 1995 - Oral administration - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)",
        "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)",
        "Greenblatt 2004 - Young females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=13)",
        "Greenblatt 2004 - Young males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)",
        "Greenblatt 2000 - Triazolam females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)",
        "Greenblatt 2000 - Triazolam males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)",
        "Greenblatt 1989 - Triazolam group - Triazolam - PO - 0.25 mg - Plasma - agg. (n=11)",
        "Greenblatt 1991 - Young subjects, 0.25 mg - Triazolam - PO - 0.25 mg - Plasma - agg. (n=26)"
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 24.0,
              "Unit": "h"
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|PO_0.25mg|Halcion|Application_1|ProtocolSchemaItem|Volume of water/body weight",
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          "Unit": "ml/kg"
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Triazolam|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Triazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Triazolam|P (intracellular->interstitial)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (interstitial->intracellular)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Triazolam|P (intracellular->interstitial)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (interstitial->intracellular)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Triazolam|P (intracellular->interstitial)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (intracellular->interstitial)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (interstitial->intracellular)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Triazolam|P (intracellular->interstitial)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (interstitial->intracellular)",
          "Value": 0.00015477761992,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Triazolam|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Triazolam|P (intracellular->interstitial)",
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        },
        {
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            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
          }
        },
        {
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            "Description": "Value updated from 'IV + Oral' on 2018-11-13 16:52"
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        }
      ],
      "OutputSelections": [
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        {
          "Name": "Triazolam",
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            "Cellular partition coefficient method - Rodgers and Rowland",
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          ],
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            {
              "AlternativeName": "Optimized",
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            }
          ],
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            {
              "Name": "CYP3A4-alpha-OH pathway",
              "MoleculeName": "CYP3A4"
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            {
              "Name": "CYP3A4-4-OH pathway",
              "MoleculeName": "CYP3A4"
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          ],
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            "Formulations": [
              {
                "Name": "Halcion",
                "Key": "Formulation"
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            ]
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      ],
      "HasResults": true,
      "IndividualAnalyses": [
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            {
              "Unit": "h",
              "Dimension": "Time",
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            {
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              "Name": "Varhe 1996a - Triazolam + placebo - Triazolam - Plasma - agg. (n=12)-ArithmeticMean",
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                "Symbol": "Circle"
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            },
            {
              "Name": "Varhe 1994 - Triazolam + placebo - Triazolam - Plasma - agg. (n=9)-ArithmeticMean",
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              "Y": "Varhe 1994 - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#C0C000",
                "LegendIndex": 12,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - Plasma - agg. (n=18)-ArithmeticMean",
              "X": "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - PO - 0.25 mg - Plasma - agg. (n=18)|Time",
              "Y": "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - PO - 0.25 mg - Plasma - agg. (n=18)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#808080",
                "LegendIndex": 11,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Lilja 2000 - Triazolam with 200 mL water - Triazolam - Plasma - agg. (n=12)-ArithmeticMean",
              "X": "Lilja 2000 - Triazolam with 200 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|Time",
              "Y": "Lilja 2000 - Triazolam with 200 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#00FF00",
                "LegendIndex": 10,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Kroboth 1995 - Oral administration - Triazolam - Plasma - agg. (n=12)-ArithmeticMean",
              "X": "Kroboth 1995 - Oral administration - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|Time",
              "Y": "Kroboth 1995 - Oral administration - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#C04000",
                "LegendIndex": 9,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - Plasma - agg. (n=10)-ArithmeticMean",
              "X": "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|Time",
              "Y": "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#C000C0",
                "LegendIndex": 8,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Greenblatt 2004 - Young females - Triazolam - Plasma - agg. (n=13)-ArithmeticMean",
              "X": "Greenblatt 2004 - Young females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=13)|Time",
              "Y": "Greenblatt 2004 - Young females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=13)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#00C0C0",
                "LegendIndex": 7,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Greenblatt 2004 - Young males - Triazolam - Plasma - agg. (n=10)-ArithmeticMean",
              "X": "Greenblatt 2004 - Young males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|Time",
              "Y": "Greenblatt 2004 - Young males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#FF8000",
                "LegendIndex": 6,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Greenblatt 2000 - Triazolam females - Triazolam - Plasma - agg. (n=8)-ArithmeticMean",
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            }
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        {
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            {
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              "Y": "Varhe 1996a - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
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            },
            {
              "Name": "Varhe 1994 - Triazolam + placebo - Triazolam - Plasma - agg. (n=9)-ArithmeticMean",
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              "Y": "Varhe 1994 - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=9)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
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            },
            {
              "Name": "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - Plasma - agg. (n=18)-ArithmeticMean",
              "X": "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - PO - 0.25 mg - Plasma - agg. (n=18)|Time",
              "Y": "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - PO - 0.25 mg - Plasma - agg. (n=18)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
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            },
            {
              "Name": "Lilja 2000 - Triazolam with 200 mL water - Triazolam - Plasma - agg. (n=12)-ArithmeticMean",
              "X": "Lilja 2000 - Triazolam with 200 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|Time",
              "Y": "Lilja 2000 - Triazolam with 200 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
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                "LineStyle": "None",
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              }
            },
            {
              "Name": "Kroboth 1995 - Oral administration - Triazolam - Plasma - agg. (n=12)-ArithmeticMean",
              "X": "Kroboth 1995 - Oral administration - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|Time",
              "Y": "Kroboth 1995 - Oral administration - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
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            },
            {
              "Name": "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - Plasma - agg. (n=10)-ArithmeticMean",
              "X": "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|Time",
              "Y": "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#C000C0",
                "LegendIndex": 8,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Greenblatt 2004 - Young females - Triazolam - Plasma - agg. (n=13)-ArithmeticMean",
              "X": "Greenblatt 2004 - Young females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=13)|Time",
              "Y": "Greenblatt 2004 - Young females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=13)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
                "Color": "#00C0C0",
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            },
            {
              "Name": "Greenblatt 2004 - Young males - Triazolam - Plasma - agg. (n=10)-ArithmeticMean",
              "X": "Greenblatt 2004 - Young males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|Time",
              "Y": "Greenblatt 2004 - Young males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
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                "LegendIndex": 6,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Greenblatt 2000 - Triazolam females - Triazolam - Plasma - agg. (n=8)-ArithmeticMean",
              "X": "Greenblatt 2000 - Triazolam females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)|Time",
              "Y": "Greenblatt 2000 - Triazolam females - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
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            },
            {
              "Name": "Greenblatt 2000 - Triazolam males - Triazolam - Plasma - agg. (n=10)-ArithmeticMean",
              "X": "Greenblatt 2000 - Triazolam males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|Time",
              "Y": "Greenblatt 2000 - Triazolam males - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)|ObservedData|Peripheral Venous Blood|Plasma|Triazolam|ArithmeticMean",
              "CurveOptions": {
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              }
            },
            {
              "Name": "Greenblatt 1989 - Triazolam group - Triazolam - Plasma - agg. (n=11)-ArithmeticMean",
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      ]
    },
    {
      "Name": "PO_0.5mg",
      "Model": "4Comp",
      "ObservedData": [
        "Villikka 1998 - Triazolam + placebo - Triazolam - PO - 0.5 mg - Plasma - agg. (n=10)",
        "Villikka 1997 - Triazolam + placebo - Triazolam - PO - 0.5 mg - Plasma - agg. (n=10)",
        "Phillips 1986 - Triazolam alone - Triazolam - PO - 0.5 mg - Plasma - agg. (n=16)",
        "Ochs 1984 - Control - Triazolam - PO - 0.5 mg - Plasma - agg. (n=5)",
        "Friedman 1988 - Control - Triazolam - PO - 0.5 mg - Plasma - agg. (n=19)",
        "Friedman 1986 - Figure 1 - Triazolam - PO - 0.5 mg - Plasma - agg. (n=54)"
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      "Solver": {},
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              "Name": "Start time",
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              "Unit": "h"
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            {
              "Name": "Resolution",
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          ]
        },
        {
          "Parameters": [
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              }
            },
            {
              "Name": "Resolution",
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              "Unit": "pts/h"
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          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|PO_0.5mg|Halcion|Application_1|ProtocolSchemaItem|Volume of water/body weight",
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          "Unit": "ml/kg"
        },
        {
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        },
        {
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        {
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        {
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        },
        {
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        {
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Triazolam|P (intracellular->interstitial)",
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Triazolam|P (interstitial->intracellular)",
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        },
        {
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        },
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          ],
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            {
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            {
              "Name": "CYP3A4-4-OH pathway",
              "MoleculeName": "CYP3A4"
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          ],
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                "Name": "Halcion",
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            "Hukkinen 1995 - Triazolam with 250 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)",
            "Kroboth 1995 - Oral administration - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)",
            "Lilja 2000 - Triazolam with 200 mL water - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)",
            "O'Connor-Semmes 2001 - Young group, triazolam alone - Triazolam - PO - 0.25 mg - Plasma - agg. (n=18)",
            "Varhe 1994 - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=9)",
            "Varhe 1996a - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=12)",
            "Varhe 1996b - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=10)",
            "Varhe 1996c - Triazolam + placebo - Triazolam - PO - 0.25 mg - Plasma - agg. (n=8)"
          ]
        }
      ]
    },
    {
      "Name": "IV",
      "Classifiables": [
        "Kroboth 1995 - IV administration - Triazolam - IV - 0.25 mg - Plasma - agg. (n=12)",
        "Smith 1987 - 0.125 mg - Triazolam - IV - 0.125 mg - Plasma - agg. (n=5)",
        "Smith 1987 - 0.25 mg - Triazolam - IV - 0.25 mg - Plasma - agg. (n=5)",
        "Smith 1987 - 0.5 mg - Triazolam - IV - 0.5 mg - Plasma - agg. (n=5)",
        "Smith 1987 - 0.75 mg - Triazolam - IV - 0.75 mg - Plasma - agg. (n=5)",
        "Smith 1987 - 1.0 mg - Triazolam - IV - 1 mg - Plasma - agg. (n=5)"
      ]
    }
  ],
  "SimulationClassifications": [
    {
      "Name": "IV",
      "Classifiables": [
        "Kroboth1995_0.25mg_iv",
        "Smith1987_0.125mg",
        "Smith1987_0.25mg",
        "Smith1987_0.5mg",
        "Smith1987_0.75mg",
        "Smith1987_1mg"
      ]
    },
    {
      "Name": "Oral",
      "Classifiables": [
        "PO_0.125mg",
        "PO_0.25mg",
        "PO_0.5mg"
      ]
    }
  ]
}