{
  "Version": 78,
  "Individuals": [
    {
      "Name": "European (P-gp modified, CYP3A4 36 h)",
      "Seed": 17189110,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "AADAC|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "AADAC|Relative expression in blood cells",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|Relative expression in plasma",
          "Value": 3.9102564103E-05
        },
        {
          "Path": "AADAC|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "AADAC|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|Reference concentration",
          "Value": 0.39140774,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "ATP1A2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "ATP1A2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "CYP2C8|Reference concentration",
          "Value": 2.56,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP2C8|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP2C8|t1/2 (liver)",
          "Value": 23.000001425,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "GABRG2|Reference concentration",
          "Value": 1.04099689,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "GABRG2|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "GABRG2|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Bone|Intracellular|AADAC|Relative expression",
          "Value": 4.8717948718E-05
        },
        {
          "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0062154033171
        },
        {
          "Path": "Organism|Bone|Intracellular|P-gp|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Brain|Intracellular|AADAC|Relative expression",
          "Value": 3.9743589744E-05
        },
        {
          "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|GABRG2|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Brain|Intracellular|P-gp|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Gonads|Intracellular|AADAC|Relative expression",
          "Value": 0.0011923076923
        },
        {
          "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0508741242
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP2C8|Relative expression",
          "Value": 0.0138116248
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Heart|Intracellular|AADAC|Relative expression",
          "Value": 0.0026602564103
        },
        {
          "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression",
          "Value": 0.3179118843
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Heart|Intracellular|P-gp|Relative expression",
          "Value": 0.0419198106
        },
        {
          "Path": "Organism|Kidney|Intracellular|AADAC|Relative expression",
          "Value": 5.7051282051E-05
        },
        {
          "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0158938619
        },
        {
          "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression",
          "Value": 0.00010384615385
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0786998764
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP2C8|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0223784807
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP2C8|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810428
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT1A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|AADAC|Relative expression",
          "Value": 0.0269230769
        },
        {
          "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0272345453
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Lung|Intracellular|P-gp|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression",
          "Value": 0.00020833333333
        },
        {
          "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression",
          "Value": 0.7034193524
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        },
        {
          "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Pancreas|Intracellular|AADAC|Relative expression",
          "Value": 0.1474358974
        },
        {
          "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0073903254795
        },
        {
          "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression",
          "Value": 0.0142510689
        },
        {
          "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0389467988
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|AADAC|Relative expression",
          "Value": 0.2544871795
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0501579923
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Spleen|Intracellular|AADAC|Relative expression",
          "Value": 0.00037115384615
        },
        {
          "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0103243118
        },
        {
          "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression",
          "Value": 0.0742555691
        },
        {
          "Path": "Organism|Stomach|Intracellular|AADAC|Relative expression",
          "Value": 0.0775641026
        },
        {
          "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression",
          "Value": 0.0309435884
        },
        {
          "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "P-gp|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "P-gp|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "P-gp|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A4|Reference concentration",
          "Value": 2.32,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "UGT1A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT1A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Molecules": [
        {
          "Name": "CYP3A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP3A4"
          }
        },
        {
          "Name": "AADAC",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
        },
        {
          "Name": "P-gp",
          "Type": "Transporter",
          "TransportType": "Efflux",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainInterstitialToPlasma",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "EffluxBrainTissueToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "EffluxMucosaIntracellularToLumen",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "EffluxIntracellularToInterstitial",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "EffluxBloodCellsToPlasma"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "EffluxInterstitialToPlasma"
            }
          ],
          "Ontogeny": {
            "Name": "P-gp",
            "Table": {
              "Name": "TableFormula",
              "Percentile": 0.0,
              "DistributionMetaData": [
                {
                  "Mean": 1E-14,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.915059E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 5.486795E-05,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0001571905,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0004502473,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.001288958,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.00368424,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.01048397,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.02946235,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.0800178,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.1994918,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.4165768,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.6716791,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.8542612,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.943803,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9796414,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.992799,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9974749,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9991173,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9996917,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9998924,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999624,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 0.9999869,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                },
                {
                  "Mean": 1.0,
                  "Deviation": 1.6,
                  "Distribution": "LogNormal"
                }
              ],
              "XName": "Postmenstrual age",
              "XDimension": "Age in years",
              "XUnit": "year(s)",
              "YName": "P-gp",
              "YDimension": "Fraction",
              "UseDerivedValues": false,
              "Points": [
                {
                  "X": 0.0,
                  "Y": 1E-14,
                  "RestartSolver": false
                },
                {
                  "X": 0.08333334,
                  "Y": 1.915059E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.1666667,
                  "Y": 5.486795E-05,
                  "RestartSolver": false
                },
                {
                  "X": 0.25,
                  "Y": 0.0001571905,
                  "RestartSolver": false
                },
                {
                  "X": 0.3333333,
                  "Y": 0.0004502473,
                  "RestartSolver": false
                },
                {
                  "X": 0.4166667,
                  "Y": 0.001288958,
                  "RestartSolver": false
                },
                {
                  "X": 0.5,
                  "Y": 0.00368424,
                  "RestartSolver": false
                },
                {
                  "X": 0.5833333,
                  "Y": 0.01048397,
                  "RestartSolver": false
                },
                {
                  "X": 0.6666667,
                  "Y": 0.02946235,
                  "RestartSolver": false
                },
                {
                  "X": 0.75,
                  "Y": 0.0800178,
                  "RestartSolver": false
                },
                {
                  "X": 0.8333333,
                  "Y": 0.1994918,
                  "RestartSolver": false
                },
                {
                  "X": 0.9166667,
                  "Y": 0.4165768,
                  "RestartSolver": false
                },
                {
                  "X": 1.0,
                  "Y": 0.6716791,
                  "RestartSolver": false
                },
                {
                  "X": 1.083333,
                  "Y": 0.8542612,
                  "RestartSolver": false
                },
                {
                  "X": 1.166667,
                  "Y": 0.943803,
                  "RestartSolver": false
                },
                {
                  "X": 1.25,
                  "Y": 0.9796414,
                  "RestartSolver": false
                },
                {
                  "X": 1.333333,
                  "Y": 0.992799,
                  "RestartSolver": false
                },
                {
                  "X": 1.416667,
                  "Y": 0.9974749,
                  "RestartSolver": false
                },
                {
                  "X": 1.5,
                  "Y": 0.9991173,
                  "RestartSolver": false
                },
                {
                  "X": 1.583333,
                  "Y": 0.9996917,
                  "RestartSolver": false
                },
                {
                  "X": 1.666667,
                  "Y": 0.9998924,
                  "RestartSolver": false
                },
                {
                  "X": 1.75,
                  "Y": 0.9999624,
                  "RestartSolver": false
                },
                {
                  "X": 1.833333,
                  "Y": 0.9999869,
                  "RestartSolver": false
                },
                {
                  "X": 3.333333,
                  "Y": 1.0,
                  "RestartSolver": false
                }
              ]
            }
          }
        },
        {
          "Name": "OATP1B1",
          "Type": "Transporter",
          "TransportType": "Influx",
          "Expression": [
            {
              "Name": "Bone",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainPlasmaToInterstitial",
              "CompartmentName": "Plasma"
            },
            {
              "Name": "Brain",
              "TransportDirection": "InfluxBrainInterstitialToTissue",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Fat",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Gonads",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Heart",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Kidney",
              "TransportDirection": "ExcretionKidney",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Stomach",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "SmallIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Duodenum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerJejunum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "UpperIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "LowerIleum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "LargeIntestine",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Caecum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonAscendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonTransversum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonDescendens",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "ColonSigmoid",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Rectum",
              "TransportDirection": "InfluxLumenToMucosaIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Periportal",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Interstitial"
            },
            {
              "Name": "Pericentral",
              "TransportDirection": "ExcretionLiver",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Lung",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Muscle",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Pancreas",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Skin",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "Spleen",
              "TransportDirection": "InfluxInterstitialToIntracellular",
              "CompartmentName": "Intracellular"
            },
            {
              "Name": "BloodCells",
              "TransportDirection": "InfluxPlasmaToBloodCells"
            },
            {
              "Name": "VascularEndothelium",
              "TransportDirection": "InfluxPlasmaToInterstitial"
            }
          ]
        },
        {
          "Name": "ATP1A2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        },
        {
          "Name": "UGT1A4",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "UGT1A4"
          }
        },
        {
          "Name": "GABRG2",
          "Type": "OtherProtein",
          "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide"
        },
        {
          "Name": "CYP2C8",
          "Type": "Enzyme",
          "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
          "Ontogeny": {
            "Name": "CYP2C8"
          }
        }
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Verapamil",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.7,
              "Unit": "Log Units"
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.1
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 43514.8753161441,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 6.54
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 1.6341738226E-05,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.92,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "rCYP450_FirstOrder",
          "DataSource": "Tracy 1999",
          "Molecule": "CYP2C8",
          "Parameters": [
            {
              "Name": "In vitro CL/recombinant enzyme",
              "Value": 0.057,
              "Unit": "µl/min/pmol rec. enzyme"
            },
            {
              "Name": "CLspec/[Enzyme]",
              "Value": 0.3179498362,
              "Unit": "l/µmol/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2019-11-26 09:16"
              }
            }
          ]
        },
        {
          "InternalName": "rCYP450_FirstOrder",
          "DataSource": "Tracy 1999",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro CL/recombinant enzyme",
              "Value": 0.8333,
              "Unit": "µl/min/pmol rec. enzyme"
            },
            {
              "Name": "CLspec/[Enzyme]",
              "Value": 4.6482034823,
              "Unit": "l/µmol/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2019-11-26 09:16"
              }
            }
          ]
        },
        {
          "InternalName": "IrreversibleInhibition",
          "DataSource": "Rowland-Yeo 2010",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "kinact",
              "Value": 0.0376212371,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
              }
            },
            {
              "Name": "K_kinact_half",
              "Value": 1.2,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 454.6,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "Midazolam",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Optimized",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.8972038771,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            }
          ]
        },
        {
          "Name": "LogP (Simcyp)",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 3.53,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Simcyp"
              }
            }
          ]
        },
        {
          "Name": "LogP (experimental) (Dagenais)",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 3.0,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Dagenais 2009"
              }
            }
          ]
        },
        {
          "Name": "LogP (GastroPlus)",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 3.37,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "GastroPlus"
              }
            }
          ]
        },
        {
          "Name": "LogP (experimental) (Rodgers & Rowland)",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 3.1,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Rodgers and Rowland"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Simcyp",
          "IsDefault": false,
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.032,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Simcyp"
              }
            }
          ]
        },
        {
          "Name": "Gertz et al. 2010",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.031,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            }
          ]
        },
        {
          "Name": "Lown et al. 1995",
          "IsDefault": false,
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.022,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Lown et al. 1995"
              }
            }
          ]
        },
        {
          "Name": "Björkman et al. 2001 (men)",
          "IsDefault": false,
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.016
            }
          ]
        },
        {
          "Name": "Björkman et al. 2001 (women)",
          "IsDefault": false,
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.02
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Aqueous solubility",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 0.13,
              "Unit": "mg/ml",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Heikkinen 2012"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 5.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Heikkinen 2012"
              }
            }
          ]
        },
        {
          "Name": "FaSSIF",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 0.049,
              "Unit": "mg/ml",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 6.5,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Heikkinen 2012"
              }
            }
          ]
        },
        {
          "Name": "FeSSIF",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 0.09,
              "Unit": "mg/ml",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Heikkinen 2012"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 5.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Heikkinen 2012"
              }
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Optimized",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 0.00015549970673,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 6.2
        },
        {
          "Type": "Acid",
          "Pka": 10.95
        }
      ],
      "Processes": [
        {
          "InternalName": "SpecificBinding",
          "DataSource": "Buhr 1997",
          "Molecule": "GABRG2",
          "Parameters": [
            {
              "Name": "koff",
              "Value": 1.0,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            },
            {
              "Name": "Kd",
              "Value": 1.8,
              "Unit": "nmol/l"
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Patki et al. 2003",
          "Molecule": "CYP3A4",
          "Metabolite": "1-OH-Midazolam",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 0.18,
              "Unit": "nmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 3.9,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "Simcyp",
          "Molecule": "CYP3A4",
          "Metabolite": "1-OH-Midazolam",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 2.16,
              "Unit": "pmol/min/pmol rec. enzyme"
            },
            {
              "Name": "Km",
              "Value": 2.16,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Optimized",
          "Molecule": "UGT1A4",
          "Metabolite": "Midazolam-N-glucuronide",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 276.0,
              "Unit": "pmol/min/mg mic. protein"
            },
            {
              "Name": "Content of CYP proteins in liver microsomes",
              "Value": 58.0,
              "Unit": "pmol/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Achour 2014"
              }
            },
            {
              "Name": "Km",
              "Value": 37.8,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            },
            {
              "Name": "kcat",
              "Value": 3.5911771641,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "Optimized",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 0.6401025724,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Optimized",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 850.0,
              "Unit": "pmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 4.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            },
            {
              "Name": "kcat",
              "Value": 8.7607941215,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'PI Hohmann iv+po, Hyland feUr MDZG, Thummel feUr unchanged - Pint' on 2019-04-09 16:10"
              }
            }
          ]
        },
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "Galentin et al. 2004",
          "Molecule": "CYP3A4",
          "Metabolite": "1-OH-Midazolam",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 1.96,
              "Unit": "pmol/min/pmol rec. enzyme"
            },
            {
              "Name": "Km",
              "Value": 2.69,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Ito et al. 2003",
          "Molecule": "CYP3A4",
          "Metabolite": "1-OH-Midazolam",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 4.41,
              "Unit": "nmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 3.8,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "GastroPlus",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 850.0,
              "Unit": "pmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 4.0,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Klieber et al. 2008",
          "Molecule": "UGT1A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 276.0,
              "Unit": "pmol/min/mg mic. protein"
            },
            {
              "Name": "Content of CYP proteins in liver microsomes",
              "Value": 58.0,
              "Unit": "pmol/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Achour 2014"
              }
            },
            {
              "Name": "Km",
              "Value": 37.8,
              "Unit": "µmol/l"
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Cl",
          "Value": 1.0
        },
        {
          "Name": "F",
          "Value": 1.0
        },
        {
          "Name": "Molecular weight",
          "Value": 325.78,
          "Unit": "g/mol"
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "solution",
      "FormulationType": "Formulation_Dissolved"
    },
    {
      "Name": "Tablet (Dormicum)",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 0.0107481462,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'PI Tablet 7.5 mg' on 2019-04-09 16:30"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 4.3802943225,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'PI Tablet 7.5 mg' on 2019-04-09 16:30"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "controlled release",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 38.5979819554,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 4' on 2019-11-26 13:43"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 1.2441115042,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 4' on 2019-11-26 13:43"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    }
  ],
  "Protocols": [
    {
      "Name": "120 mg PO SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 120.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "80 mg PO SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 80.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "0.1 mg/kg IV SD",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.1,
          "Unit": "mg/kg"
        },
        {
          "Name": "Infusion time",
          "Value": 5.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "10 mg IV SD over 5 min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 10.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 5.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "5 mg IV SD over 10 min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 5.0,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 10.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "120 mg BID over 10 days",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_12_12",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 120.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 228.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "120 mg BID over 8 days",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_12_12",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 120.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 180.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "120 mg TID - 7 doses",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_8_8_8",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 120.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 56.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    },
    {
      "Name": "240 mg PO SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 240.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "16 mg PO SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 16.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "0.1 mg PO SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.1,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "80 mg TID - 7 doses",
      "ApplicationType": "Oral",
      "DosingInterval": "DI_8_8_8",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 80.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Name": "End time",
          "Value": 56.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ]
    }
  ],
  "Simulations": [
    {
      "Name": "Barbarash 1988 + McAllister 1982 (10 mg IV SD)",
      "Model": "4Comp",
      "ObservedData": [
        "McAllister 1982 - Verapamil 10 mg IV - Verapamil - IV - 10 mg - Plasma - agg. (n=20)",
        "Barbarash 1988 - Verapamil IV control - Verapamil - IV - 10 mg - Serum - agg. (n=6)"
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|10 mg IV SD over 5 min|Application_1|ProtocolSchemaItem|Infusion time",
          "Value": 5.0,
          "Unit": "min"
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Caecum_int_Caecum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
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        {
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        {
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        {
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        {
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          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
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      "OutputSelections": [
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      "HasResults": true,
      "IndividualAnalyses": [
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              "Dimension": "Time",
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                "LineStyle": "None",
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        },
        {
          "Parameters": [
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            },
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        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (intracellular->interstitial)",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (intracellular->interstitial)",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
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          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
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          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
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          }
        },
        {
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          }
        },
        {
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      ],
      "OutputSelections": [
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            },
            {
              "Name": "McAllister 1982 - Verapamil 120 mg PO - Verapamil - PO - 120 mg - Plasma - agg. (n=20)-Verapamil-Peripheral Venous Blood-Plasma-ArithmeticMean",
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            {
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        {
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        },
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        {
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        },
        {
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        },
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        {
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        },
        {
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      "OutputSelections": [
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        },
        {
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        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
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        },
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        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)",
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)",
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        },
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        },
        {
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        {
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        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)",
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          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)",
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          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
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        },
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        {
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          }
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        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
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        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)",
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          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (intracellular->interstitial)",
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          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
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        },
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        {
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        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
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        {
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        },
        {
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        {
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (interstitial->intracellular)",
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
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          "Unit": "cm/min",
          "ValueOrigin": {
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
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          }
        },
        {
          "Path": "Neighborhoods|UpperIleum_int_UpperIleum_cell|Verapamil|P (interstitial->intracellular)",
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          }
        },
        {
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        },
        {
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        },
        {
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      "OutputSelections": [
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        },
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            },
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        },
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        },
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          }
        },
        {
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          }
        },
        {
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          }
        },
        {
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          }
        },
        {
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          }
        },
        {
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)",
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          "Unit": "cm/min",
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            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
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            "Source": "ParameterIdentification",
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            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)",
          "Value": 0.0015095540335,
          "Unit": "cm/min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 2' on 2019-11-26 10:33"
          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)",
          "Value": 0.0015095540335,
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        },
        {
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        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Verapamil|P (intracellular->interstitial)",
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        },
        {
          "Path": "Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
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        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Verapamil|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Verapamil|P (intracellular->interstitial)",
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        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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        },
        {
          "Path": "Neighborhoods|Duodenum_int_Duodenum_cell|Verapamil|P (intracellular->interstitial)",
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        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (interstitial->intracellular)",
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          "Unit": "cm/min",
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        },
        {
          "Path": "Neighborhoods|LowerIleum_int_LowerIleum_cell|Verapamil|P (intracellular->interstitial)",
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          }
        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (interstitial->intracellular)",
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        },
        {
          "Path": "Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Verapamil|P (intracellular->interstitial)",
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        },
        {
          "Path": "Neighborhoods|Rectum_int_Rectum_cell|Verapamil|P (interstitial->intracellular)",
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        },
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