{
  "Version": 79,
  "ExpressionProfiles": [
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "P-gp",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "Organism|Bone|Intracellular|P-gp|Relative expression",
          "Value": 0.0242518189
        },
        {
          "Path": "Organism|Brain|Intracellular|P-gp|Relative expression",
          "Value": 0.07608904
        },
        {
          "Path": "Organism|Gonads|Intracellular|P-gp|Relative expression",
          "Value": 0.017417973
        },
        {
          "Path": "Organism|Heart|Intracellular|P-gp|Relative expression",
          "Value": 0.0419198107
        },
        {
          "Path": "Organism|Kidney|Intracellular|P-gp|Relative expression",
          "Value": 0.7092198582
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.1108416465
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|P-gp|Relative expression",
          "Value": 0.3971631206
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810427
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|P-gp|Relative expression",
          "Value": 0.1916810427
        },
        {
          "Path": "Organism|Lung|Intracellular|P-gp|Relative expression",
          "Value": 0.0657549316
        },
        {
          "Path": "Organism|Muscle|Intracellular|P-gp|Relative expression",
          "Value": 0.0128342959
        },
        {
          "Path": "Organism|Pancreas|Intracellular|P-gp|Relative expression",
          "Value": 0.0142510688
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|P-gp|Relative expression",
          "Value": 0.2808543974
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|P-gp|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Spleen|Intracellular|P-gp|Relative expression",
          "Value": 0.0742555692
        },
        {
          "Path": "Organism|Stomach|Intracellular|P-gp|Relative expression",
          "Value": 0.0260852897
        },
        {
          "Path": "P-gp|Reference concentration",
          "Value": 1.41,
          "Unit": "µmol/l"
        },
        {
          "Path": "P-gp|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "P-gp|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "TransportType": "Efflux",
      "Expression": [
        {
          "Name": "Bone",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainInterstitialToPlasma",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "EffluxBrainTissueToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "EffluxMucosaIntracellularToLumen",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Lung",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Muscle",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pancreas",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Skin",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Spleen",
          "TransportDirection": "EffluxIntracellularToInterstitial",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "BloodCells",
          "TransportDirection": "EffluxBloodCellsToPlasma"
        },
        {
          "Name": "VascularEndothelium",
          "TransportDirection": "EffluxInterstitialToPlasma"
        }
      ]
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP3A4",
      "Category": "European (P-gp modified, CYP3A4 36 h)",
      "Parameters": [
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "CYP3A4"
      }
    }
  ],
  "Individuals": [
    {
      "Name": "Härtter 2012 SD, n=19",
      "Seed": 968530812,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 40.526,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 72.632,
          "Unit": "kg"
        },
        "Height": {
          "Value": 174.053,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Eichelbaum 1984, n=1\u001f",
      "Seed": -2045030578,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 25.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 91.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 201.115,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Smith 1984, n=8",
      "Seed": 1569567109,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "WhiteAmerican_NHANES_1997",
        "Gender": "MALE",
        "Age": {
          "Value": 26.6,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Blume, Mutschler 1994, n=24",
      "Seed": 1649318031,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.54,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 75.88,
          "Unit": "kg"
        },
        "Height": {
          "Value": 179.25,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Maeda 2011, n=8",
      "Seed": 846556953,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "Japanese_Population",
        "Gender": "MALE",
        "Age": {
          "Value": 26.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 64.3,
          "Unit": "kg"
        },
        "Height": {
          "Value": 176.25,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Wing 1985, n=1",
      "Seed": 209332546,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 21.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 70.0,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "McAllister, Kirsten 1982, n=20",
      "Seed": 210558984,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 25.2,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Freedman 1981, n=1",
      "Seed": 556085593,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 40.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 72.0,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Abernethy 1993, n=1",
      "Seed": 617216828,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 20.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 79.0,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Vogelgesang 1984, n=1",
      "Seed": 636367828,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 25.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 79.5,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "John 1992, n=6",
      "Seed": 644002703,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 26.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Sawicki, Janicki 2002, n=12",
      "Seed": 645574750,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 26.2,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 70.67,
          "Unit": "kg"
        },
        "Height": {
          "Value": 171.8,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Choi 2008, n=12",
      "Seed": 705586046,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "Asian_Tanaka_1996",
        "Gender": "MALE",
        "Age": {
          "Value": 23.8,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 66.3,
          "Unit": "kg"
        },
        "Height": {
          "Value": 172.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Ratiopharm 1988, n=16",
      "Seed": 717692562,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 31.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 77.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 177.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Ratiopharm 1989, n=16",
      "Seed": 717758468,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 26.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 74.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 179.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Johnson 2001, n=12",
      "Seed": 725752093,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 28.5,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Boehringer 2018, n=12",
      "Seed": 728577281,
      "OriginData": {
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          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 39.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 86.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 181.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
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    },
    {
      "Name": "Härtter 2012 MD, n=20",
      "Seed": 797382593,
      "OriginData": {
        "CalculationMethods": [
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          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 38.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 73.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 175.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Hla 1987, n=10",
      "Seed": 799032281,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 34.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
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        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Mikus 1990, n=1",
      "Seed": 817052484,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 34.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 76.5,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "van Haarst 2009, n=10",
      "Seed": 1068782375,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 25.5,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 73.5,
          "Unit": "kg"
        },
        "Height": {
          "Value": 179.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Blume, Mutschler 1983, n=12",
      "Seed": 1137070750,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "FEMALE",
        "Age": {
          "Value": 27.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 65.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 168.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Blume, Mutschler 1990, n=24",
      "Seed": 1137160578,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 25.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 74.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 180.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Blume, Mutschler 1989, n=18",
      "Seed": 1137232171,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 26.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 70.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 179.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Blume, Mutschler 1987, n=12",
      "Seed": 1137275031,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 28.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 66.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 175.0,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Barbarash 1988, n=6",
      "Seed": 1150876046,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 30.5,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Abernethy 1985, n=1",
      "Seed": 1151206687,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 24.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 67.0,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Johnston 1981, n=6",
      "Seed": 1153175125,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 26.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 64.7,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Mooy 1985, n=5",
      "Seed": 1158337906,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 37.5,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Streit 2005, n=10",
      "Seed": 1159871687,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 26.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 73.5,
          "Unit": "kg"
        },
        "Height": {
          "Value": 179.5,
          "Unit": "cm"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)",
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Backman 1994",
      "Seed": 114811484,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "FEMALE",
        "Age": {
          "Value": 23.5,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 67.5,
          "Unit": "kg"
        }
      },
      "ExpressionProfiles": [
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)",
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Jorgensen 1988, n = 12",
      "Seed": 354326781,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 52.8,
          "Unit": "year(s)"
        }
      },
      "ExpressionProfiles": [
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)",
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Karim 1995, n = 12",
      "Seed": 375046171,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 25.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 73.0,
          "Unit": "kg"
        },
        "Height": {
          "Value": 177.0,
          "Unit": "cm"
        }
      },
      "ExpressionProfiles": [
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)",
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    },
    {
      "Name": "Shand 1981, n = 6",
      "Seed": 376698437,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 51.5,
          "Unit": "year(s)"
        }
      },
      "ExpressionProfiles": [
        "CYP3A4|Human|European (P-gp modified, CYP3A4 36 h)",
        "P-gp|Human|European (P-gp modified, CYP3A4 36 h)"
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "R-Verapamil",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "logP",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.8407448658,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 5.1,
              "Unit": "%",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVivo"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 46.0,
              "Unit": "mg/ml"
            },
            {
              "Name": "Reference pH",
              "Value": 6.54
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 3.5447164381E-06,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "Permeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Permeability",
              "Value": 0.0994098912,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.75,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0
            }
          ]
        },
        {
          "InternalName": "ActiveTransport_InVitro_VesicularAssay_MM",
          "DataSource": "Paper",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "In vitro Vmax/transporter",
              "Value": 0.00057724,
              "Unit": "pmol/min/pmol transporter"
            },
            {
              "Name": "Km",
              "Value": 1.01,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 12.5970868779,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ],
          "Description": "A transporter mediated unidirectional transfer of a compound across a cellular membrane is described as saturable process following Michaelis-Menten type kinetics. The corresponding kcat value is calculated from a specific Vmax normalized to the amount of transporter as input value which was determined in a vesicular transport assay."
        },
        {
          "InternalName": "NoncompetitiveInhibition",
          "DataSource": "Non-competitive",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 0.0383697779,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "IrreversibleInhibition",
          "DataSource": "MBI",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "kinact",
              "Value": 0.038,
              "Unit": "1/min"
            },
            {
              "Name": "K_kinact_half",
              "Value": 27.63,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Norverapamil",
          "Molecule": "CYP3A4",
          "Metabolite": "R-Norverapamil",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 1.27,
              "Unit": "nmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 19.59,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 34.9352466212,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "D617",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 1.17,
              "Unit": "nmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 35.34,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 43.9812289146,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 454.611,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "S-Verapamil",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "logP",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.8407448658,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 11.0,
              "Unit": "%",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVivo"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 46.0,
              "Unit": "mg/ml"
            },
            {
              "Name": "Reference pH",
              "Value": 6.54
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 3.5447164381E-06,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "Permeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Permeability",
              "Value": 0.0994098912,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.75,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0
            }
          ]
        },
        {
          "InternalName": "ActiveTransport_InVitro_VesicularAssay_MM",
          "DataSource": "Paper",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "In vitro Vmax/transporter",
              "Value": 0.00057724,
              "Unit": "pmol/min/pmol transporter"
            },
            {
              "Name": "Km",
              "Value": 1.01,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 12.5970868779,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ],
          "Description": "A transporter mediated unidirectional transfer of a compound across a cellular membrane is described as saturable process following Michaelis-Menten type kinetics. The corresponding kcat value is calculated from a specific Vmax normalized to the amount of transporter as input value which was determined in a vesicular transport assay."
        },
        {
          "InternalName": "NoncompetitiveInhibition",
          "DataSource": "Non-competitive",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 0.0383697779,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "IrreversibleInhibition",
          "DataSource": "MBI",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "kinact",
              "Value": 0.034,
              "Unit": "1/min"
            },
            {
              "Name": "K_kinact_half",
              "Value": 3.85,
              "Unit": "µmol/l"
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Norverapamil",
          "Molecule": "CYP3A4",
          "Metabolite": "S-Norverapamil",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 1.02,
              "Unit": "nmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 9.72,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 26.1743386639,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "D617",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 0.86,
              "Unit": "nmol/min/mg mic. protein"
            },
            {
              "Name": "Km",
              "Value": 23.64,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 56.4245798193,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 454.611,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "R-Norverapamil",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "logP",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.8407448658,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 5.1,
              "Unit": "%",
              "ValueOrigin": {
                "Source": "Other",
                "Method": "Assumption"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 46.0,
              "Unit": "mg/ml"
            },
            {
              "Name": "Reference pH",
              "Value": 6.54
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 3.5447164381E-06,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "Permeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Permeability",
              "Value": 0.0994098912,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.75,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "D620",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 9.0,
              "Unit": "pmol/min/pmol rec. enzyme"
            },
            {
              "Name": "Km",
              "Value": 144.0,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 145.6385399671,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0
            }
          ]
        },
        {
          "InternalName": "ActiveTransport_InVitro_VesicularAssay_MM",
          "DataSource": "Paper",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "In vitro Vmax/transporter",
              "Value": 0.00057724,
              "Unit": "pmol/min/pmol transporter"
            },
            {
              "Name": "Km",
              "Value": 1.01,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 3.3916609583,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ],
          "Description": "A transporter mediated unidirectional transfer of a compound across a cellular membrane is described as saturable process following Michaelis-Menten type kinetics. The corresponding kcat value is calculated from a specific Vmax normalized to the amount of transporter as input value which was determined in a vesicular transport assay."
        },
        {
          "InternalName": "NoncompetitiveInhibition",
          "DataSource": "Non-competitive",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 0.0383697779,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "IrreversibleInhibition",
          "DataSource": "MBI",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "kinact",
              "Value": 0.048,
              "Unit": "1/min"
            },
            {
              "Name": "K_kinact_half",
              "Value": 6.1,
              "Unit": "µmol/l"
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 440.584,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "S-Norverapamil",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "logP",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.8407448658,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 11.0,
              "Unit": "%",
              "ValueOrigin": {
                "Source": "Other",
                "Method": "Assumption"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 46.0,
              "Unit": "mg/ml"
            },
            {
              "Name": "Reference pH",
              "Value": 6.54
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 3.5447164381E-06,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "Permeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Permeability",
              "Value": 0.0994098912,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.75,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "D620",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 6.5,
              "Unit": "pmol/min/pmol rec. enzyme"
            },
            {
              "Name": "Km",
              "Value": 36.0,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 41.0994047535,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "GFR",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0
            }
          ]
        },
        {
          "InternalName": "ActiveTransport_InVitro_VesicularAssay_MM",
          "DataSource": "Paper",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "In vitro Vmax/transporter",
              "Value": 0.00057724,
              "Unit": "pmol/min/pmol transporter"
            },
            {
              "Name": "Km",
              "Value": 1.01,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 3.3916609583,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ],
          "Description": "A transporter mediated unidirectional transfer of a compound across a cellular membrane is described as saturable process following Michaelis-Menten type kinetics. The corresponding kcat value is calculated from a specific Vmax normalized to the amount of transporter as input value which was determined in a vesicular transport assay."
        },
        {
          "InternalName": "NoncompetitiveInhibition",
          "DataSource": "Non-competitive",
          "Molecule": "P-gp",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 0.0383697779,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '30b - final' on 2019-12-30 13:23"
              }
            }
          ]
        },
        {
          "InternalName": "IrreversibleInhibition",
          "DataSource": "MBI",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "kinact",
              "Value": 0.08,
              "Unit": "1/min"
            },
            {
              "Name": "K_kinact_half",
              "Value": 2.9,
              "Unit": "µmol/l"
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 440.584,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "Sum-Verapamil",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "logP",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.8407448658,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 8.05,
              "Unit": "%"
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 46.0,
              "Unit": "mg/ml"
            },
            {
              "Name": "Reference pH",
              "Value": 6.54
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 3.5447164381E-06,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "Permeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Permeability",
              "Value": 0.0994098912,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.75,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 454.611,
          "Unit": "g/mol"
        }
      ]
    },
    {
      "Name": "Sum-Norverapamil",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "logP",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.8407448658,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 8.05,
              "Unit": "%"
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 46.0,
              "Unit": "mg/ml"
            },
            {
              "Name": "Reference pH",
              "Value": 6.54
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 3.5447164381E-06,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "Permeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Permeability",
              "Value": 0.0994098912,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.75,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 440.584,
          "Unit": "g/mol"
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "Solution",
      "FormulationType": "Formulation_Dissolved"
    },
    {
      "Name": "Retard Tablet Verapamil (Knoll)",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 155.2445399403,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from '240 mg retard (Isoptin RR) QD vs Verabeta 240 RR' on 2019-12-31 11:13"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 2.3662989419,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from '240 mg retard (Isoptin RR) QD vs Verabeta 240 RR' on 2019-12-31 11:13"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    }
  ],
  "Protocols": [
    {
      "Name": "Härtter 2012, Verapamil 120 mg SD, R-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 55.545,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Härtter 2012, Verapamil 120 mg SD, S-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 55.545,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Eichelbaum 1984, R-Verapamil 50 mg iv (5 min)",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 46.288,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 5.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Maeda 2011, Verapamil 16 mg po SD (sol), R-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 7.406,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 2.0,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Maeda 2011, Verapamil 16 mg po SD (sol), S-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 7.406,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 2.0,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Blume, Mutschler 1994, 240 mg po QD (SR), R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 111.091,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 6.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Blume, Mutschler 1994, 240 mg po QD (SR), S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 111.091,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 6.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Smith 1984, Verapamil 10 mg iv (bol), R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "IntravenousBolus",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 4.629,
                  "Unit": "mg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Smith 1984, Verapamil 10 mg iv (bol), S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "IntravenousBolus",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 4.629,
                  "Unit": "mg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Mooy 1985, Verapamil 3mg iv (5min) SD, R-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1.388651,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 5.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Mooy 1985, Verapamil 3mg iv (5min) SD, S-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 1.388651,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 5.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Mooy 1985, Verapamil 80mg po SD, R-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 37.03069,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Mooy 1985, Verapamil 80mg po SD, S-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 37.03069,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Streit 2005, Verapamil 5mg iv (10min) SD, S-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.314418,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 10.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Streit 2005, Verapamil 5mg iv (10min) SD, R-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 2.314418,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 10.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Johnston 1981, Verapamil 0.1mg/kg iv (5min) SD, S-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.04628836,
          "Unit": "mg/kg"
        },
        {
          "Name": "Infusion time",
          "Value": 5.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Johnston 1981, Verapamil 0.1mg/kg iv (5min) SD, R-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 0.04628836,
          "Unit": "mg/kg"
        },
        {
          "Name": "Infusion time",
          "Value": 5.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Johnston 1981, Verapamil 120mg po SD, R-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 55.54603,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Johnston 1981, Verapamil 120mg po SD, S-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 55.54603,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Abernethy 1985, Verapamil 10mg iv (10min) SD, R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 4.628836,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 10.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 12.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Abernethy 1985, Verapamil 10mg iv (10min) SD, S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 4.628836,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 10.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 12.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Abernethy 1985, Verapamil 120mg po SD, R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.54603,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
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              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 12.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Abernethy 1985, Verapamil 120mg po SD, S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.54603,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 12.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Barbarash 1988, Verapamil 10mg iv (10min) SD, S-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 4.628836,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 10.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Barbarash 1988, Verapamil 10mg iv (10min) SD, R-Vera",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 4.628836,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 10.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Barbarash 1988, Verapamil 120mg po SD, R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.54603,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
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              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Barbarash 1988, Verapamil 120mg po SD, S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.54603,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
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              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Wing 1985, Verapamil 10mg iv (10min) SD, R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 4.628836,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 10.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Wing 1985, Verapamil 10mg iv (10min) SD, S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Intravenous",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 4.628836,
                  "Unit": "mg"
                },
                {
                  "Name": "Infusion time",
                  "Value": 10.0,
                  "Unit": "min"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
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        {
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        {
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                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "McAllister 1982, Verapamil 120 mg SD, R-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 55.545,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "McAllister 1982, Verapamil 120 mg SD, S-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 55.545,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Jorgensen 1988, Verapamil 120mg PO BID, R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.54603,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 15.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Jorgensen 1988, Verapamil 120mg PO BID, S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.54603,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 15.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Jorgensen 1988, Verapamil 240mg PO MD, R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 111.0921,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 8.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Jorgensen 1988, Verapamil 240mg PO MD, S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 111.0921,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 8.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Karim 1995, Verapamil 240mg PO SD, R-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 111.0921,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Karim 1995, Verapamil 240mg PO SD, S-Vera",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 111.0921,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Shand 1981, Verapamil 120 mg TID, R-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.545,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 7.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 8.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Shand 1981, Verapamil 120 mg TID, S-Vera",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 55.545,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 7.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 8.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    }
  ],
  "ObserverSets": [
    {
      "Name": "Sum-Verapamil",
      "Observers": [
        {
          "Name": "Sum-Verapamil Plasma (Peripheral Venous Blood)",
          "Dimension": "Concentration (molar)",
          "ContainerCriteria": [
            {
              "Tag": "PeripheralVenousBlood",
              "Type": "MatchTag"
            }
          ],
          "Formula": {
            "Name": "Sum-Verapamil",
            "Formula": "fQ_art*(C_pls_art_R+C_pls_art_S)+fQ_bon*(C_pls_bon_R+C_pls_bon_S)+fQ_fat*(C_pls_fat_R+C_pls_fat_S)+fQ_mus*(C_pls_mus_R+C_pls_mus_S)+fQ_skn*(C_pls_skn_R+C_pls_skn_S)",
            "References": [
              {
                "Alias": "C_pls_art_R",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|ArterialBlood|Plasma|R-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_bon_R",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Bone|Plasma|R-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_fat_R",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Fat|Plasma|R-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_mus_R",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Muscle|Plasma|R-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_skn_R",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Skin|Plasma|R-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_art_S",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|ArterialBlood|Plasma|S-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_bon_S",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Bone|Plasma|S-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_fat_S",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Fat|Plasma|S-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_mus_S",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Muscle|Plasma|S-Verapamil|Concentration"
              },
              {
                "Alias": "C_pls_skn_S",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Skin|Plasma|S-Verapamil|Concentration"
              },
              {
                "Alias": "fQ_art",
                "Dimension": "Fraction",
                "Path": "Organism|ArterialBlood|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_bon",
                "Dimension": "Fraction",
                "Path": "Organism|Bone|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_fat",
                "Dimension": "Fraction",
                "Path": "Organism|Fat|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_mus",
                "Dimension": "Fraction",
                "Path": "Organism|Muscle|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_skn",
                "Dimension": "Fraction",
                "Path": "Organism|Skin|Peripheral blood flow fraction"
              }
            ],
            "Dimension": "Concentration (molar)"
          },
          "MoleculeList": {
            "ForAll": false,
            "MoleculeNamesToInclude": [
              "R-Verapamil"
            ]
          },
          "Type": "Container"
        }
      ]
    },
    {
      "Name": "Sum-Norverapamil",
      "Observers": [
        {
          "Name": "Sum-Norverapamil Plasma (Peripheral Venous Blood)",
          "Dimension": "Concentration (molar)",
          "ContainerCriteria": [
            {
              "Tag": "PeripheralVenousBlood",
              "Type": "MatchTag"
            }
          ],
          "Formula": {
            "Name": "Sum-Norverapamil",
            "Formula": "fQ_art*(C_pls_art_RN+C_pls_art_SN)+fQ_bon*(C_pls_bon_RN+C_pls_bon_SN)+fQ_fat*(C_pls_fat_RN+C_pls_fat_SN)+fQ_mus*(C_pls_mus_RN+C_pls_mus_SN)+fQ_skn*(C_pls_skn_RN+C_pls_skn_SN)",
            "References": [
              {
                "Alias": "C_pls_art_RN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|ArterialBlood|Plasma|R-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_bon_RN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Bone|Plasma|R-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_fat_RN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Fat|Plasma|R-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_mus_RN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Muscle|Plasma|R-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_skn_RN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Skin|Plasma|R-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_art_SN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|ArterialBlood|Plasma|S-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_bon_SN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Bone|Plasma|S-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_fat_SN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Fat|Plasma|S-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_mus_SN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Muscle|Plasma|S-Norverapamil|Concentration"
              },
              {
                "Alias": "C_pls_skn_SN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Skin|Plasma|S-Norverapamil|Concentration"
              },
              {
                "Alias": "fQ_art",
                "Dimension": "Fraction",
                "Path": "Organism|ArterialBlood|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_bon",
                "Dimension": "Fraction",
                "Path": "Organism|Bone|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_fat",
                "Dimension": "Fraction",
                "Path": "Organism|Fat|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_mus",
                "Dimension": "Fraction",
                "Path": "Organism|Muscle|Peripheral blood flow fraction"
              },
              {
                "Alias": "fQ_skn",
                "Dimension": "Fraction",
                "Path": "Organism|Skin|Peripheral blood flow fraction"
              }
            ],
            "Dimension": "Concentration (molar)"
          },
          "MoleculeList": {
            "ForAll": false,
            "MoleculeNamesToInclude": [
              "R-Norverapamil"
            ]
          },
          "Type": "Container"
        }
      ]
    },
    {
      "Name": "Sum-Verapamil fe to urine",
      "Observers": [
        {
          "Name": "Sum-Verapamil fe to urine",
          "Dimension": "Fraction",
          "ContainerCriteria": [
            {
              "Tag": "Urine",
              "Type": "MatchTag"
            }
          ],
          "Formula": {
            "Name": "Sum-Verapamil fe to urine",
            "Formula": "(TotalDrugMassR+TotalDrugMassS)>0 ? ((UrineConcR+UrineConcS)*Volume)/(TotalDrugMassR+TotalDrugMassS) : 0",
            "References": [
              {
                "Alias": "TotalDrugMassR",
                "Dimension": "Amount",
                "Path": "R-Verapamil|Total drug mass"
              },
              {
                "Alias": "UrineConcR",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Kidney|Urine|R-Verapamil|Concentration"
              },
              {
                "Alias": "UrineConcS",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Kidney|Urine|S-Verapamil|Concentration"
              },
              {
                "Alias": "Volume",
                "Dimension": "Volume",
                "Path": "Organism|Kidney|Urine|Volume"
              },
              {
                "Alias": "TotalDrugMassS",
                "Dimension": "Amount",
                "Path": "S-Verapamil|Total drug mass"
              }
            ],
            "Dimension": "Fraction"
          },
          "MoleculeList": {
            "ForAll": false,
            "MoleculeNamesToInclude": [
              "R-Verapamil"
            ]
          },
          "Type": "Amount"
        }
      ]
    },
    {
      "Name": "Sum-Norverapamil fe to urine",
      "Observers": [
        {
          "Name": "Sum-Norverapamil fe to urine",
          "Dimension": "Fraction",
          "ContainerCriteria": [
            {
              "Tag": "Urine",
              "Type": "MatchTag"
            }
          ],
          "Formula": {
            "Name": "Sum-Norverapamil fe to urine",
            "Formula": "(TotalDrugMassR+TotalDrugMassS)>0 ? ((UrineConcRN+UrineConcSN)*Volume)/(TotalDrugMassR+TotalDrugMassS) : 0",
            "References": [
              {
                "Alias": "TotalDrugMassR",
                "Dimension": "Amount",
                "Path": "R-Verapamil|Total drug mass"
              },
              {
                "Alias": "UrineConcRN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Kidney|Urine|R-Norverapamil|Concentration"
              },
              {
                "Alias": "UrineConcSN",
                "Dimension": "Concentration (molar)",
                "Path": "Organism|Kidney|Urine|S-Norverapamil|Concentration"
              },
              {
                "Alias": "Volume",
                "Dimension": "Volume",
                "Path": "Organism|Kidney|Urine|Volume"
              },
              {
                "Alias": "TotalDrugMassS",
                "Dimension": "Amount",
                "Path": "S-Verapamil|Total drug mass"
              }
            ],
            "Dimension": "Fraction"
          },
          "MoleculeList": {
            "ForAll": false,
            "MoleculeNamesToInclude": [
              "R-Norverapamil"
            ]
          },
          "Type": "Amount"
        }
      ]
    },
    {
      "Name": "Sum-Verapamil fe to feces",
      "Observers": [
        {
          "Name": "Sum-Verapamil fe to feces",
          "Dimension": "Fraction",
          "ContainerCriteria": [
            {
              "Tag": "Feces",
              "Type": "MatchTag"
            }
          ],
          "Formula": {
            "Name": "Sum-Verapamil fe to feces",
            "Formula": "(TotalDrugMassR+TotalDrugMassS)>0 ? (MR+MS)/(TotalDrugMassR+TotalDrugMassS) : 0",
            "References": [
              {
                "Alias": "TotalDrugMassR",
                "Dimension": "Amount",
                "Path": "R-Verapamil|Total drug mass"
              },
              {
                "Alias": "MR",
                "Dimension": "Amount",
                "Path": "..|..|R-Verapamil"
              },
              {
                "Alias": "MS",
                "Dimension": "Amount",
                "Path": "..|..|S-Verapamil"
              },
              {
                "Alias": "TotalDrugMassS",
                "Dimension": "Amount",
                "Path": "S-Verapamil|Total drug mass"
              }
            ],
            "Dimension": "Fraction"
          },
          "MoleculeList": {
            "ForAll": false,
            "MoleculeNamesToInclude": [
              "R-Verapamil"
            ]
          },
          "Type": "Amount"
        }
      ]
    },
    {
      "Name": "Sum-Norverapamil fe to feces",
      "Observers": [
        {
          "Name": "Sum-Norverapamil fe to feces",
          "Dimension": "Fraction",
          "ContainerCriteria": [
            {
              "Tag": "Feces",
              "Type": "MatchTag"
            }
          ],
          "Formula": {
            "Name": "Sum-Norverapamil fe to feces",
            "Formula": "(TotalDrugMassR+TotalDrugMassS)>0 ? (MRN+MSN)/(TotalDrugMassR+TotalDrugMassS) : 0",
            "References": [
              {
                "Alias": "TotalDrugMassR",
                "Dimension": "Amount",
                "Path": "R-Verapamil|Total drug mass"
              },
              {
                "Alias": "MRN",
                "Dimension": "Amount",
                "Path": "..|..|R-Norverapamil"
              },
              {
                "Alias": "MSN",
                "Dimension": "Amount",
                "Path": "..|..|S-Norverapamil"
              },
              {
                "Alias": "TotalDrugMassS",
                "Dimension": "Amount",
                "Path": "S-Verapamil|Total drug mass"
              }
            ],
            "Dimension": "Fraction"
          },
          "MoleculeList": {
            "ForAll": false,
            "MoleculeNamesToInclude": [
              "R-Norverapamil"
            ]
          },
          "Type": "Amount"
        }
      ]
    }
  ],
  "Simulations": [
    {
      "Name": "iv_R-Verapamil 50 mg (5 min), Eichelbaum 1984, n=1",
      "Model": "4Comp",
      "ObservedData": [
        "Eichelbaum 1984 - Subject 4 - R-Verapamil - IV - 50 mg - Plasma - indiv."
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 1.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 25.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 1.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
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  "ObservedDataClassifications": [
    {
      "Name": "IV SD",
      "Classifiables": [
        "Barbarash 1988 - Verapamil IV control - Verapamil - IV - 10 mg - Serum - agg. (n=6)",
        "McAllister 1982 - Verapamil 10 mg IV - Verapamil - IV - 10 mg - Plasma - agg. (n=20)",
        "Streit 2005 - intravenous verapamil during normoxia (5 mg) - Verapamil - IV - 5 mg - Plasma - agg. (n=10)",
        "Eichelbaum 1984 - Subject 4 - R-Verapamil - IV - 5 mg - Plasma - indiv.",
        "Eichelbaum 1984 - Subject 4 - R-Verapamil - IV - 25 mg - Plasma - indiv.",
        "Eichelbaum 1984 - Subject 4 - R-Verapamil - IV - 50 mg - Plasma - indiv.",
        "Eichelbaum 1984 - Subject 4 - S-Verapamil - IV - 5 mg - Plasma - indiv.",
        "Eichelbaum 1984 - Subject 4 - S-Verapamil - IV - 7.5 mg - Plasma - indiv.",
        "Eichelbaum 1984 - Subject 4 - S-Verapamil - IV - 10 mg - Plasma - indiv.",
        "Streit et al. 2005 - intravenous verapamil during normoxia (5 mg) - Norverapamil - IV - 5 mg - Plasma - agg. (n=10)",
        "Abernethy et al. 1985 - 10mg Verapamil without cimetidine, IV - Verapamil - IV - 10 mg - Plasma - indiv.",
        "Freedman et al. 1981 - Control Subject (Subject number 4) - Verapamil - IV - 13.1 mg - Plasma - indiv.",
        "Abernethy et al. 1993 - Representative younger subject - Verapamil - IV - 20 mg - Plasma - indiv.",
        "Abernethy et al. 1993 - Representative younger subject - R-Verapamil - IV - 20 mg - Plasma - indiv.",
        "Abernethy et al. 1993 - Representative younger subject - S-Verapamil - IV - 20 mg - Plasma - indiv.",
        "Johnston 1981 - Verapamil IV - Verapamil - IV - 0.1 mg/kg - Plasma - agg. (n=6)",
        "Mooy et al. 1985 - Normal volunteers, 3mg IV - Verapamil - IV - 3 mg - Plasma - agg. (n=5)",
        "Smith 1984 - IV 10 mg Verapamil control - Verapamil - IV - 10 mg - Plasma - agg. (n=8)",
        "Wing et al. 1985 - 10mg Verapamil without cimetidine, IV - Verapamil - IV - 10 mg - Plasma - indiv."
      ]
    },
    {
      "Name": "po SD",
      "Classifiables": [
        "Barbarash 1988 - Verapamil PO control - Verapamil - PO - 120 mg - Serum - agg. (n=6)",
        "McAllister 1982 - Verapamil 80 mg PO - Verapamil - PO - 80 mg - Plasma - agg. (n=20)",
        "McAllister 1982 - Verapamil 120 mg PO - Verapamil - PO - 120 mg - Plasma - agg. (n=20)",
        "McAllister 1982 - Verapamil 160 mg PO - Verapamil - PO - 160 mg - Plasma - agg. (n=20)",
        "Hla 1987 - conventional Verapamil 120mg once daily (day 1) - Verapamil - PO - 120 mg - Plasma - agg. (n=10)",
        "Karim 1995 - Verapamil total IR fasting - Verapamil - PO - 240 mg - Plasma - agg. (n=12)",
        "Karim 1995 - Verapamil total SR fed - Verapamil - PO - 240 mg - Plasma - agg. (n=12)",
        "Abernethy et al. 1985 - 120mg Verapamil without cimetidine, PO - Verapamil - PO - 120 mg - Plasma - indiv.",
        "Vogelgesang et al. 1984 - Healthy volunteers - R-Verapamil - PO - 250 mg - Plasma - indiv.",
        "Choi et al. 2008 - 60mg Verapamil in absence of oral atorvastatin - Verapamil - PO - 60 mg - Arterial Plasma - agg. (n=12)",
        "Choi et al. 2008 - 60mg Verapamil in absence of oral atorvastatin - Norverapamil - PO - 60 mg - Arterial Plasma - agg. (n=12)",
        "Ratiopharm 1988 - Unknown - Verapamil - PO - 80 mg - Plasma - agg. (n=16)",
        "Ratiopharm 1988 - Unknown - Norverapamil - PO - 80 mg - Plasma - agg. (n=16)",
        "Ratiopharm 1989 - Unknown - Verapamil - PO - 80 mg - Plasma - agg. (n=16)",
        "Ratiopharm 1989 - Unknown - Norverapamil - PO - 80 mg - Plasma - agg. (n=16)",
        "Boehringer 2018 - Unknown - R-Verapamil - PO - 120 mg - Plasma - agg. (n=12)",
        "Boehringer 2018 - Unknown - S-Verapamil - PO - 120 mg - Plasma - agg. (n=12)",
        "Boehringer 2018 - Unknown - R-Norverapamil - PO - 120 mg - Plasma - agg. (n=12)",
        "Boehringer 2018 - Unknown - S-Norverapamil - PO - 120 mg - Plasma - agg. (n=12)",
        "Härtter et al. 2012 - 120mg po SD - R-Verapamil - PO - 120 mg - Plasma - agg. (n=19)",
        "Härtter et al. 2012 - 120mg po SD - S-Verapamil - PO - 120 mg - Plasma - agg. (n=19)",
        "Härtter et al. 2012 - 120mg po SD - R-Norverapamil - PO - 120 mg - Plasma - agg. (n=19)",
        "Härtter et al. 2012 - 120mg po SD - S-Norverapamil - PO - 120 mg - Plasma - agg. (n=19)",
        "Blume, Mutschler 1983 - Verapamil - Verapamil - PO - 40 mg - Plasma - agg. (n=12)",
        "Blume, Mutschler 1990 - Verapamil - Verapamil - PO - 40 mg - Plasma - agg. (n=24)",
        "Blume, Mutschler 1989 - Verapamil - Verapamil - PO - 80 mg - Plasma - agg. (n=18)",
        "Blume, Mutschler 1987 - Verapamil - Verapamil - PO - 120 mg - Plasma - agg. (n=12)",
        "Maeda 2011 - Verapamil 16 mg - Verapamil - PO - 16 mg - Plasma - agg. (n=8)",
        "Maeda 2011 - Verapamil 16 mg - Norverapamil - Norverapamil - PO - 16 mg - Plasma - agg. (n=8)",
        "Maeda 2011 - Verapamil 0.1 mg - Verapamil - PO - 0.1 mg - Plasma - agg. (n=8)",
        "Maeda 2011 - Verapamil 0.1 mg - Norverapamil - Norverapamil - PO - 0.1 mg - Plasma - agg. (n=8)",
        "Maeda 2011 - Verapamil 3 mg - Verapamil - PO - 3 mg - Plasma - agg. (n=8)",
        "Maeda 2011 - Verapamil 3 mg - Norverapamil - Norverapamil - PO - 3 mg - Plasma - agg. (n=8)",
        "Maeda 2011 - Verapamil 80 mg - Verapamil - PO - 80 mg - Plasma - agg. (n=8)",
        "Maeda 2011 - Verapamil 80 mg - Norverapamil - Norverapamil - PO - 80 mg - Plasma - agg. (n=8)",
        "Sawicki, Janicki 2002 - Healthy volunteers; conventional tablets - Verapamil - PO - 40 mg - Plasma - agg. (n=12)",
        "Sawicki, Janicki 2002 - Healthy volunteers; conventional tablets - Norverapamil - PO - 40 mg - Plasma - agg. (n=12)",
        "John et al. 1992 - Healthy volunteers - Verapamil - PO - 40 mg - Plasma - agg. (n=6)",
        "Johnston 1981 - Verapamil PO - Verapamil - PO - 120 mg - Plasma - agg. (n=6)",
        "Johnston 1981 - Verapamil PO - Norverapamil - PO - 120 mg - Plasma - agg. (n=6)",
        "Mooy et al. 1985 - Normal volunteers, 80mg PO - Verapamil - PO - 80 mg - Plasma - agg. (n=6)",
        "Mooy et al. 1985 - Normal volunteers, 80mg PO - Norverapamil - PO - 80 mg - Plasma - agg. (n=6)",
        "Smith 1984 - PO 120 mg Verapamil control - Verapamil - PO - 120 mg - Plasma - agg. (n=8)",
        "Wing et al. 1985 - 80mg Verapamil without cimetidine, PO - Verapamil - PO - 80 mg - Plasma - indiv.",
        "Mikus et al. 1990 - 160mg verapamil without cimetidine, PO - R-Verapamil - PO - 160 mg - Plasma - indiv.",
        "Mikus et al. 1990 - 160mg verapamil without cimetidine, PO - S-Verapamil - PO - 160 mg - Plasma - indiv."
      ]
    },
    {
      "Name": "po MD",
      "Classifiables": [
        "Backman 1994 - Verapamil - Verapamil - PO - 80 mg - Plasma - agg. (n=9)",
        "Hla 1987 - conventional Verapamil 120mg twice daily (day 10) - Verapamil - PO - 120 mg - Plasma - agg. (n=10)",
        "Jorgensen 1988 - Conventional Verapamil 120 mg BID (day 1 - 5 and 8) - Verapamil - PO - 120 mg - Plasma - agg. (n=12)",
        "Jorgensen 1988 - Conventional Verapamil 120 mg BID (day 8) - Verapamil - PO - 120 mg - Plasma - agg. (n=12)",
        "Jorgensen 1988 - Sustained release Verapamil 240 mg OD (day 1 - 5 and 8) - Verapamil - PO - 240 mg - Plasma - agg. (n=12)",
        "Jorgensen 1988 - Sustained release Verapamil 240 mg OD (day 8) - Verapamil - PO - 240 mg - Plasma - agg. (n=12)",
        "Shand 1981 - Verapamil day 1 - Verapamil - PO - 120 mg - Plasma - agg. (n=6)",
        "Shand 1981 - Verapamil day 3 (after 7th dose) - Verapamil - PO - 120 mg - Plasma - agg. (n=6)",
        "Johnson 2001 - Verapamil Steady State - Verapamil - PO - 80 mg - Plasma - agg. (n=12)",
        "Härtter et al. 2012 - 120mg po bid - R-Verapamil - PO - 120 mg - Plasma - agg. (n=20)",
        "Härtter et al. 2012 - 120mg po bid - S-Verapamil - PO - 120 mg - Plasma - agg. (n=20)",
        "Härtter et al. 2012 - 120mg po bid - R-Norverapamil - PO - 120 mg - Plasma - agg. (n=20)",
        "Härtter et al. 2012 - 120mg po bid - S-Norverapamil - PO - 120 mg - Plasma - agg. (n=20)",
        "van Haarst et al. 2009 - Verapamil only - Verapamil - PO - 180 mg - Plasma - agg. (n=10)",
        "van Haarst et al. 2009 - Verapamil only - Norverapamil - PO - 180 mg - Plasma - agg. (n=10)",
        "Blume, Mutschler 1994 - Verapamil - Verapamil - PO - 240 mg - Plasma - agg. (n=24)",
        "Johnson 2001 - Verapamil Steady State - Norverapamil - PO - 80 mg - Plasma - agg. (n=12)"
      ]
    }
  ],
  "SimulationClassifications": [
    {
      "Name": "IV SD",
      "Classifiables": [
        "iv_R-Verapamil 50 mg (5 min), Eichelbaum 1984, n=1",
        "iv_Verapamil 3 mg SD (5min), Mooy 1985, n=5",
        "iv_Verapamil 5 mg SD (5min), Streit 2005, n=10",
        "iv_Verapamil 0.1 mg/kg SD (5min), Johnston 1981, n=6",
        "iv_Verapamil 10mg SD (10min), Abernethy 1985, n=1",
        "iv_Verapamil 10mg SD (10min), Barbarash 1988, n=6",
        "iv_Verapamil 10mg SD (5min), McAllister, Kirsten 1982, n=20",
        "iv_Verapamil 13.1 mg SD (13min), Freedman 1981, n=1",
        "iv_Verapamil 20mg SD (30min), Abernethy 1993, n=1",
        "iv_R-Verapamil 5 mg (5 min), Eichelbaum 1984, n=1",
        "iv_R-Verapamil 25 mg (5 min), Eichelbaum 1984, n=1",
        "iv_S-Verapamil 5 mg SD (5min), Eichelbaum 1984, n=1",
        "iv_S-Verapamil 7.5 mg SD (5min), Eichelbaum 1984, n=1",
        "iv_S-Verapamil 10 mg SD (5min), Eichelbaum 1984, n=1",
        "iv_Verapamil 10 mg (bol), Smith 1984, n=8",
        "iv_Verapamil 10mg SD (10min), Wing 1985, n=1"
      ]
    },
    {
      "Name": "PO SD",
      "Classifiables": [
        "po_Verapamil 120 mg SD (IR), Haertter 2012, n=19",
        "po_Verapamil 16 mg SD (sol), Maeda 2011, n=8",
        "po_Verapamil 80 mg SD, Mooy 1985, n=6",
        "po_Verapamil 120 mg SD, Johnston 1981, n=6",
        "po_Verapamil 120mg SD, Abernethy 1985, n=1",
        "po_R-Verapamil 250mg SD, Vogelgesang 1984, n=1",
        "po_Verapamil 0.1 mg SD (sol), Maeda 2011, n=8",
        "po_Verapamil 3 mg SD (sol), Maeda 2011, n=8",
        "po_Verapamil 80 mg SD (sol), Maeda 2011, n=8",
        "po_Verapamil 40 mg SD, John 1992, n=6",
        "po_Verapamil 40 mg SD, Sawicki, Janicki 2002, n=12",
        "po_Verapamil 60 mg SD, Choi 2008, n=12",
        "po_Verapamil 80 mg SD, Ratiopharm 1988, n=16",
        "po_Verapamil 80 mg (2 40mg tab) SD, Ratiopharm 1989, n=16",
        "po_Verapamil 120 mg (IR tab) SD, Boehringer 2018, n=12",
        "po_Verapamil 120 mg SD, Hla 1987, n=10",
        "po_Verapamil 80 mg SD, Blume, Mutschler 1989, n=18",
        "po_Verapamil 120 mg SD, Blume, Mutschler 1987, n=12",
        "po_Verapamil 40 mg SD, Blume, Mutschler 1990, n=24",
        "po_Verapamil 40 mg SD, Blume, Mutschler 1983, n=12",
        "po_Verapamil 120 mg SD, Barbarash 1988, n=6",
        "po_Verapamil 80mg SD, McAllister, Kirsten 1982, n=20",
        "po_Verapamil 120mg SD, McAllister, Kirsten 1982, n=20",
        "po_Verapamil 160mg SD, McAllister, Kirsten 1982, n=20",
        "po_Verapamil 240 mg SD, Karim 1995, n=12",
        "po_Verapamil 120 mg SD, Smith 1984, n=8",
        "po_Verapamil 80mg SD, Wing 1985, n=1",
        "po_Verapamil 160 mg SD, Mikus 1990, n=1"
      ]
    },
    {
      "Name": "PO MD",
      "Classifiables": [
        "po_Verapamil 240 mg QD (SR), Blume, Mutschler 1994, n=24",
        "po_Verapamil 80 mg tid 7rep, Johnson 2001, n=12",
        "po_Verapamil 120 mg (IR) bid 3days, Haertter 2012, n=20",
        "po_Verapamil 120 mg MD, Hla 1987, n=10",
        "po_Verapamil 180mg PO BID 3days,van Haarst 2009, n=10",
        "po_Verapamil 80mg PO TID 5rep, Backman 1994, n=9",
        "po_Verapamil 120mg PO BID 8days, Jorgensen 1988, n=12",
        "po_Verapamil 240mg PO OD 8days sustained realese, Jorgensen 1988, n=12",
        "po_Verapamil 120mg PO TID 7rep, Shand 1981, n=6"
      ]
    }
  ]
}